diosgenin

Summary

Summary: A spirostan found in DIOSCOREA and other plants. The 25S isomer is called yamogenin. Solasodine is a natural derivative formed by replacing the spiro-ring with a nitrogen, which can rearrange to SOLANINE.

Top Publications

  1. Uemura T, Hirai S, Mizoguchi N, Goto T, Lee J, Taketani K, et al. Diosgenin present in fenugreek improves glucose metabolism by promoting adipocyte differentiation and inhibiting inflammation in adipose tissues. Mol Nutr Food Res. 2010;54:1596-608 pubmed publisher
    ..In addition, we identified diosgenin, a major aglycone of saponins in fenugreek to promote adipocyte differentiation and to inhibit expressions of ..
  2. Alcantara E, Shin M, Sohn H, Park Y, Kim T, Lim J, et al. Diosgenin stimulates osteogenic activity by increasing bone matrix protein synthesis and bone-specific transcription factor Runx2 in osteoblastic MC3T3-E1 cells. J Nutr Biochem. 2011;22:1055-63 pubmed publisher
    b>Diosgenin, a steroid saponin extracted from the root of wild yam (Dioscorea villossa) is claimed to have osteogenic property. However, detailed studies providing evidence to this claim have not been fully undertaken...
  3. Tada Y, Kanda N, Haratake A, Tobiishi M, Uchiwa H, Watanabe S. Novel effects of diosgenin on skin aging. Steroids. 2009;74:504-11 pubmed publisher
    ..The extracts contain large amounts of the plant steroid, diosgenin. Here, we studied the safety and efficacy of diosgenin against skin aging at the time of climacteric...
  4. Cailleteau C, Micallef L, Lepage C, Cardot P, Beneytout J, Liagre B, et al. Investigating the relationship between cell cycle stage and diosgenin-induced megakaryocytic differentiation of HEL cells using sedimentation field-flow fractionation. Anal Bioanal Chem. 2010;398:1273-83 pubmed publisher
    Differentiation therapy could be one strategy for stopping cancer cell proliferation. A plant steroid, diosgenin, is known to induce megakaryocytic differentiation in human erythroleukemia (HEL) cells...
  5. Corbiere C, Liagre B, Terro F, Beneytout J. Induction of antiproliferative effect by diosgenin through activation of p53, release of apoptosis-inducing factor (AIF) and modulation of caspase-3 activity in different human cancer cells. Cell Res. 2004;14:188-96 pubmed
    Previously, we demonstrated that a plant steroid, diosgenin, altered cell cycle distribution and induced apoptosis in the human osteosarcoma 1547 cell line...
  6. Lepage C, Leger D, Bertrand J, Martin F, Beneytout J, Liagre B. Diosgenin induces death receptor-5 through activation of p38 pathway and promotes TRAIL-induced apoptosis in colon cancer cells. Cancer Lett. 2011;301:193-202 pubmed publisher
    Previously, we demonstrated that diosgenin induced apoptosis in colorectal cancer cell lines HCT-116 and HT-29. HT-29 cells have been reported to be one of the most resistant colorectal cancer cell lines to TRAIL-induced apoptosis...
  7. Zhang R, Li P, Xu L, Chen Y, Sui P, Zhou L, et al. Enhancement of diosgenin production in Dioscorea zingiberensis cell culture by oligosaccharide elicitor from its endophytic fungus Fusarium oxysporum Dzf17. Nat Prod Commun. 2009;4:1459-62 pubmed
    b>Diosgenin accumulation in cell suspension cultures of Dioscorea zingiberensis C. H. Wright was enhanced by treatment with saccharide elicitors from its endophytic fungus Fusarium oxysporum isolate Dzf17...
  8. Shishodia S, Aggarwal B. Diosgenin inhibits osteoclastogenesis, invasion, and proliferation through the downregulation of Akt, I kappa B kinase activation and NF-kappa B-regulated gene expression. Oncogene. 2006;25:1463-73 pubmed
    b>Diosgenin, a steroidal saponin present in fenugreek (Trigonella foenum graecum) and other plants, has been shown to suppress inflammation, inhibit proliferation, and induce apoptosis in a variety of tumor cells, but through a mechanism ..
  9. Kosters A, Frijters R, Kunne C, Vink E, Schneiders M, Schaap F, et al. Diosgenin-induced biliary cholesterol secretion in mice requires Abcg8. Hepatology. 2005;41:141-50 pubmed
    The plant sterol diosgenin has been shown to stimulate biliary cholesterol secretion in mice without affecting the expression of the adenosine triphosphate-binding cassette transporter heterodimer Abcg5/g8...

More Information

Publications62

  1. Lee M, Yuet Wa J, Kong S, Yu B, Eng Choon V, Nai Ching H, et al. Effects of polyphyllin D, a steroidal saponin in Paris polyphylla, in growth inhibition of human breast cancer cells and in xenograft. Cancer Biol Ther. 2005;4:1248-54 pubmed
    ..All these findings provide novel insights that polyphyllin D could serve as a candidate in breast cancer treatment. ..
  2. Moalic S, Liagre B, Corbiere C, Bianchi A, Dauca M, Bordji K, et al. A plant steroid, diosgenin, induces apoptosis, cell cycle arrest and COX activity in osteosarcoma cells. FEBS Lett. 2001;506:225-30 pubmed
    ..Previously, we demonstrated that a plant steroid, diosgenin, was a new megakaryocytic differentiation inducer of human erythroleukemia cells...
  3. Xiao L, Guo D, Hu C, Shen W, Shan L, Li C, et al. Diosgenin promotes oligodendrocyte progenitor cell differentiation through estrogen receptor-mediated ERK1/2 activation to accelerate remyelination. Glia. 2012;60:1037-52 pubmed publisher
    ..b>Diosgenin, a plant-derived steroid, has been implicated for therapeutic use in many diseases, but little is known about ..
  4. Hirai S, Uemura T, Mizoguchi N, Lee J, Taketani K, Nakano Y, et al. Diosgenin attenuates inflammatory changes in the interaction between adipocytes and macrophages. Mol Nutr Food Res. 2010;54:797-804 pubmed publisher
    ..b>Diosgenin, a saponin aglycon found in a variety of plants, has anti-inflammatory properties...
  5. Srinivasan S, Koduru S, Kumar R, Venguswamy G, Kyprianou N, DAMODARAN C. Diosgenin targets Akt-mediated prosurvival signaling in human breast cancer cells. Int J Cancer. 2009;125:961-7 pubmed publisher
    ..The purpose of this study is to determine effect of diosgenin (fenugreek), a dietary compound on Akt signaling and its downstream targets on estrogen receptor positive (ER(+))..
  6. Chiang C, Way T, Tsai S, Lin J. Diosgenin, a naturally occurring steroid, suppresses fatty acid synthase expression in HER2-overexpressing breast cancer cells through modulating Akt, mTOR and JNK phosphorylation. FEBS Lett. 2007;581:5735-42 pubmed
    ..In this study, diosgenin, a plant-derived steroid, was found to be effective in suppressing FAS expression in HER2-overexpressing breast ..
  7. Chen P, Shih Y, Huang H, Cheng H. Diosgenin, a steroidal saponin, inhibits migration and invasion of human prostate cancer PC-3 cells by reducing matrix metalloproteinases expression. PLoS ONE. 2011;6:e20164 pubmed publisher
    b>Diosgenin, a steroidal saponin obtained from fenugreek (Trigonella foenum graecum), was found to exert anti-carcinogenic properties, such as inhibiting proliferation and inducing apoptosis in a variety of tumor cells...
  8. Lee J, Jung K, Kim Y, Park D. Diosgenin inhibits melanogenesis through the activation of phosphatidylinositol-3-kinase pathway (PI3K) signaling. Life Sci. 2007;81:249-54 pubmed
    ..In order to evaluate the depigmenting capacity of diosgenin and elucidate its mechanism of action, several experiments were performed in B16 melanoma cells...
  9. Das S, Dey K, Dey G, Pal I, Majumder A, Maitichoudhury S, et al. Antineoplastic and apoptotic potential of traditional medicines thymoquinone and diosgenin in squamous cell carcinoma. PLoS ONE. 2012;7:e46641 pubmed publisher
    Thymoquinone (TQ) and diosgenin (DG), the active ingredients obtained from black cumin (Nigella sativa) and fenugreek (Trigonella foenum graecum), respectively, exert potent bioactivity, including anticancer effects...
  10. Salimeh A, Mohammadi M, Rashidi B. Preconditioning with diosgenin and treadmill exercise preserves the cardiac toxicity of isoproterenol in rats. J Physiol Biochem. 2013;69:255-65 pubmed publisher
    This study was aimed to evaluate the preventive effect of diosgenin and exercise on tissue antioxidant status in isoproterenol-induced myocardial infarction (MI) in male Wistar rats...
  11. Choi K, Park H, Jung D, Kim T, Park Y, Kim B, et al. Inhibition of TNF-?-induced adhesion molecule expression by diosgenin in mouse vascular smooth muscle cells via downregulation of the MAPK, Akt and NF-?B signaling pathways. Vascul Pharmacol. 2010;53:273-80 pubmed publisher
    ..b>Diosgenin, a precursor of steroid hormones, has been shown to have a variety of biological activities including anti-..
  12. Temel R, Brown J, Ma Y, Tang W, Rudel L, Ioannou Y, et al. Diosgenin stimulation of fecal cholesterol excretion in mice is not NPC1L1 dependent. J Lipid Res. 2009;50:915-23 pubmed publisher
    b>Diosgenin exists in some food supplements and herbal medicines and lowers plasma cholesterol by increasing fecal cholesterol excretion...
  13. Huang C, Liu D, Jan T. Diosgenin, a plant-derived sapogenin, enhances regulatory T-cell immunity in the intestine of mice with food allergy. J Nat Prod. 2010;73:1033-7 pubmed publisher
    It was hypothesized that the suppressive effect of diosgenin (1) on the intestinal T helper (Th)2 responses is associated with an enhancement of the regulatory T-cell immunity...
  14. Kwon C, Sohn H, Kim S, Kim J, Son K, Lee J, et al. Anti-obesity effect of Dioscorea nipponica Makino with lipase-inhibitory activity in rodents. Biosci Biotechnol Biochem. 2003;67:1451-6 pubmed
    ..Dioscin and its aglycone, diosgenin, both suppressed the time-dependent increase of blood triacylglycerol level when orally injected with corn oil ..
  15. Cai J, Liu M, Wang Z, Ju Y. Apoptosis induced by dioscin in Hela cells. Biol Pharm Bull. 2002;25:193-6 pubmed
    ..The reduced expression of the survival protein Bcl-2 also confirmed this result. These studies may be significant in finding a new drug to treat human cervical cancer. ..
  16. Li P, Mou Y, Shan T, Xu J, Li Y, Lu S, et al. Effects of polysaccharide elicitors from endophytic Fusarium oxysporium Dzf17 on growth and diosgenin production in cell suspension culture of Dioscorea zingiberensis. Molecules. 2011;16:9003-16 pubmed publisher
    ..The effects of the time of addition and polysaccharide concentration on the growth and diosgenin accumulation in cell suspension culture of D. zingiberensis were studied...
  17. Benghuzzi H, Tucci M, Eckie R, Hughes J. The effects of sustained delivery of diosgenin on the adrenal gland of female rats. Biomed Sci Instrum. 2003;39:335-40 pubmed
    b>Diosgenin is a steroidal saponin, which is extracted from the root of Wild Yam (Dioscorea villosa). It has been reported to have tremendous medical applications...
  18. Ma H, Zhao Z, Wang L, Wang Y, Zhou Q, Wang B. [Comparative study on anti-hypercholesterolemia activity of diosgenin and total saponin of Dioscorea panthaica]. Zhongguo Zhong Yao Za Zhi. 2002;27:528-31 pubmed
    To compare the anti-hypercholesterolemic and cholesterol absorption inhibitory activities between total saponin of Dioscorea panthaica (TSDP) and diosgenin (Dio).
  19. Sun B, Zheng L, Bao Y, Yu C, Wu Y, Meng X, et al. Reversal effect of Dioscin on multidrug resistance in human hepatoma HepG2/adriamycin cells. Eur J Pharmacol. 2011;654:129-34 pubmed publisher
    ..These results suggest that Dioscin is a potent multidrug resistance reversal agent and may be a potential adjunctive agent for tumor chemotherapy. ..
  20. Leger D, Liagre B, Cardot P, Beneytout J, Battu S. Diosgenin dose-dependent apoptosis and differentiation induction in human erythroleukemia cell line and sedimentation field-flow fractionation monitoring. Anal Biochem. 2004;335:267-78 pubmed
    ..Then, we used, as an in vitro cellular model of apoptosis and differentiation, diosgenin dose-dependent induction in the polyvalent human erythroleukemia cell line...
  21. Gao M, Chen L, Yu H, Sun Q, Kou J, Yu B. Diosgenin down-regulates NF-?B p65/p50 and p38MAPK pathways and attenuates acute lung injury induced by lipopolysaccharide in mice. Int Immunopharmacol. 2013;15:240-5 pubmed publisher
    b>Diosgenin (Dio), a major active component of steroidal sapogenin of the traditional Chinese herb Dioscorea zingiberensis C.H...
  22. Huang C, Ku C, Jan T. Diosgenin attenuates allergen-induced intestinal inflammation and IgE production in a murine model of food allergy. Planta Med. 2009;75:1300-5 pubmed publisher
    b>Diosgenin, the major sapogenin contained in the Chinese yam, has recently been shown to promote systemic T helper 1-type immunity in a murine model of airway hypersensitivity...
  23. Pari L, Monisha P, Mohamed Jalaludeen A. Beneficial role of diosgenin on oxidative stress in aorta of streptozotocin induced diabetic rats. Eur J Pharmacol. 2012;691:143-50 pubmed publisher
    The present study was designed to investigate the beneficial role of diosgenin on oxidative stress markers and histopathological changes in aorta of streptozotocin induced diabetic rats...
  24. McAnuff M, Omoruyi F, Morrison E, Asemota H. Changes in some liver enzymes in streptozotocin-induced diabetic rats fed sapogenin extract from bitter yam (Dioscorea polygonoides) or commercial diosgenin. West Indian Med J. 2005;54:97-101 pubmed
    The effects of steroidal sapogenin extract from bitter yam or commercial diosgenin on liver enzyme changes were investigated Diabetic male Wistar rats were fed diets supplemented with 1% steroidal sapogenin extract or commercial ..
  25. Taylor W, Elder J, Chang P, Richards K. Microdetermination of diosgenin from fenugreek (Trigonella foenum-graecum) seeds. J Agric Food Chem. 2000;48:5206-10 pubmed
    ..hydrolysis of steroidal glycosides of Amber fenugreek was studied by capillary gas chromatographic analysis of diosgenin [(25R)-spirost-5-en-3-ol] and isomeric spirostadiene artifacts from 100 mg samples of seed material...
  26. Tohda C, Urano T, Umezaki M, Nemere I, Kuboyama T. Diosgenin is an exogenous activator of 1,25D?-MARRS/Pdia3/ERp57 and improves Alzheimer's disease pathologies in 5XFAD mice. Sci Rep. 2012;2:535 pubmed publisher
    The aim of this study was to investigate the effects and the mechanism of diosgenin, a famous plant-derived steroidal sapogenin, on memory deficits in Alzheimer's disease (AD) model mice...
  27. Corbiere C, Liagre B, Bianchi A, Bordji K, Dauça M, Netter P, et al. Different contribution of apoptosis to the antiproliferative effects of diosgenin and other plant steroids, hecogenin and tigogenin, on human 1547 osteosarcoma cells. Int J Oncol. 2003;22:899-905 pubmed
    ..We compared the biological activity of diosgenin with hecogenin and tigogenin, plant steroids structurally close to diosgenin, on proliferation rate, cell cycle ..
  28. Wang Y, Che C, Chiu J, He Q. Dioscin (saponin)-induced generation of reactive oxygen species through mitochondria dysfunction: a proteomic-based study. J Proteome Res. 2007;6:4703-10 pubmed
    ..The current study provided detailed evidence to support that dioscin is capable of inducing apoptosis in mammalian cells, in which the mitochondria-initiated apoptosis pathway plays an important role. ..
  29. Chang C, Kuan T, Hsieh Y, Ho Y, Sun Y, Lin C. Effects of diosgenin on myometrial matrix metalloproteinase-2 and -9 activity and expression in ovariectomized rats. Int J Biol Sci. 2011;7:837-47 pubmed
    b>Diosgenin, a traditional Yam extraction, has been used in hormone replacement for menopausal women...
  30. Raju J, Patlolla J, Swamy M, Rao C. Diosgenin, a steroid saponin of Trigonella foenum graecum (Fenugreek), inhibits azoxymethane-induced aberrant crypt foci formation in F344 rats and induces apoptosis in HT-29 human colon cancer cells. Cancer Epidemiol Biomarkers Prev. 2004;13:1392-8 pubmed
    ..We evaluated the preventive efficacy of dietary fenugreek seed and its major steroidal saponin constituent, diosgenin, on azoxymethane-induced rat colon carcinogenesis during initiation and promotion stages...
  31. Narula A, Kumar S, Srivastava P. Genetic fidelity of in vitro regenerants, encapsulation of shoot tips and high diosgenin content in Dioscorea bulbifera L., a potential alternative source of diosgenin. Biotechnol Lett. 2007;29:623-9 pubmed
    Dioscorea bulbifera L. containing the pharmaceutically important compound, diosgenin, was regenerated in vitro through nodal segments on supplemented Murashige and Skoog medium (MS)...
  32. Manivannan J, Barathkumar T, Sivasubramanian J, Arunagiri P, Raja B, Balamurugan E. Diosgenin attenuates vascular calcification in chronic renal failure rats. Mol Cell Biochem. 2013;378:9-18 pubmed publisher
    ..This present study intends to evaluate the dose-dependent effect of diosgenin, an antioxidant on high phosphate induced vascular calcification in adenine-induced chronic renal failure rats...
  33. Chiu C, Chiu Y, Wu L, Lu T, Huang T, Hsieh M, et al. Diosgenin ameliorates cognition deficit and attenuates oxidative damage in senescent mice induced by D-galactose. Am J Chin Med. 2011;39:551-63 pubmed
    This study attempted to access the neuroprotective effect of diosgenin on the senescent mice induced by d-galactose (D-gal)...
  34. Lu B, Xu Y, Xu L, Cong X, Yin L, Li H, et al. Mechanism investigation of dioscin against CCl4-induced acute liver damage in mice. Environ Toxicol Pharmacol. 2012;34:127-135 pubmed publisher
  35. Uemura T, Goto T, Kang M, Mizoguchi N, Hirai S, Lee J, et al. Diosgenin, the main aglycon of fenugreek, inhibits LXR? activity in HepG2 cells and decreases plasma and hepatic triglycerides in obese diabetic mice. J Nutr. 2011;141:17-23 pubmed publisher
    ..cells and we determined by liquid chromatography tandem MS that the active substance contained in fraction 11 is diosgenin. Diosgenin (5 and 10 ?mol/L) inhibited the accumulation of TG and the expression of lipogenic genes in HepG2 ..
  36. Lijuan W, Kupittayanant P, Chudapongse N, Wray S, Kupittayanant S. The effects of wild ginger (Costus speciosus (Koen) Smith) rhizome extract and diosgenin on rat uterine contractions. Reprod Sci. 2011;18:516-24 pubmed publisher
    ..Although significant amounts of diosgenin were present in the extract, we found that, depending upon its concentration, diosgenin had either no effect or ..
  37. Li P, Mao Z, Lou J, Li Y, Mou Y, Lu S, et al. Enhancement of diosgenin production in Dioscorea zingiberensis cell cultures by oligosaccharides from its endophytic fungus Fusarium oxysporum Dzf17. Molecules. 2011;16:10631-44 pubmed publisher
    The effects of the oligosaccharides from the endophytic fungus Fusarium oxysporum Dzf17 as elicitors on diosgenin production in cell suspension cultures of its host Dioscorea zingiberensis were investigated...
  38. Liu M, Yue P, Wang Z, Wong R. Methyl protodioscin induces G2/M arrest and apoptosis in K562 cells with the hyperpolarization of mitochondria. Cancer Lett. 2005;224:229-41 pubmed
    ..Taken together, these data demonstrated that methyl protodioscin inhibits K562 cell proliferation via G2/M arrest and apoptosis, with mitochondrial hyperpolarization and the disruption of Ca2+ homeostasis playing important roles. ..
  39. Lecanu L, Rammouz G, McCourty A, Sidahmed E, Greeson J, Papadopoulos V. Caprospinol reduces amyloid deposits and improves cognitive function in a rat model of Alzheimer's disease. Neuroscience. 2010;165:427-35 pubmed publisher
    ..These results position caprospinol as a promising drug candidate for AD treatment. ..
  40. Kaskiw M, Tassotto M, Mok M, Tokar S, Pycko R, TH NG J, et al. Structural analogues of diosgenyl saponins: synthesis and anticancer activity. Bioorg Med Chem. 2009;17:7670-9 pubmed publisher
    ..The incorporation of an aromatic nitro functionality into these saponin analogues does not exhibit significant effect on their cytotoxic activity. ..
  41. Bian D, Li Z, Ma H, Mu S, Ma C, Cui B, et al. Effects of diosgenin on cell proliferation induced by IGF-1 in primary human thyrocytes. Arch Pharm Res. 2011;34:997-1005 pubmed publisher
    ..Our aim here was to evaluate the possible effects of diosgenin on cell proliferation induced by IGF-1 in primary human thyroid cells...
  42. Kang T, Moon E, Hong B, Choi S, Son M, Park J, et al. Diosgenin from Dioscorea nipponica ameliorates diabetic neuropathy by inducing nerve growth factor. Biol Pharm Bull. 2011;34:1493-8 pubmed
    ..In this study, we investigated the regulation of NGF by steroid diosgenin (DG) in a diabetic neuropathy rodent model...
  43. Wang S, Cai B, Cui C, Liu H, Wu C, Yao X. Diosgenin-3-O-alpha-L-rhamnopyranosyl-(1 --> 4)-beta-D-glucopyranoside obtained as a new anticancer agent from Dioscorea futschauensis induces apoptosis on human colon carcinoma HCT-15 cells via mitochondria-controlled apoptotic pathway. J Asian Nat Prod Res. 2004;6:115-25 pubmed
    b>Diosgenin-3-O-alpha-L-rhamnopyranosyl-(1 --> 4)-beta-D-glucopyranoside (DRG) is a well-known pentacyclic triterpene glycoside newly isolated from the rhizomes of Dioscorea futschauensis R. Kunth (Dioscoreaceae) by our group...
  44. Raju J, Mehta R. Cancer chemopreventive and therapeutic effects of diosgenin, a food saponin. Nutr Cancer. 2009;61:27-35 pubmed publisher
    ..b>Diosgenin, a naturally occurring steroid saponin found abundantly in legumes and yams, is a well-known precursor of ..
  45. Liagre B, Leger D, Vergne Salle P, Beneytout J. MAP kinase subtypes and Akt regulate diosgenin-induced apoptosis of rheumatoid synovial cells in association with COX-2 expression and prostanoid production. Int J Mol Med. 2007;19:113-22 pubmed
    In the present study, we investigated the signalling pathways involved in diosgenin-induced apoptosis in human rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) in vitro with particular interest on Akt and MAPKs activation in ..
  46. Al Matubsi H, Nasrat N, Oriquat G, Abu Samak M, Al Mzain K, Salim M. The hypocholesterolemic and antioxidative effect of dietary diosgenin and chromium chloride supplementation on high-cholesterol fed Japanese quails. Pak J Biol Sci. 2011;14:425-32 pubmed
    The current study investigated the effect of natural diosgenin extracted from fenugreek seeds, in comparison with the pure standard diosgenin, plus chromium chloride (CrCl3) supplementation on high-cholesterol fed Japanese quails...
  47. Lepage C, Liagre B, Cook Moreau J, Pinon A, Beneytout J. Cyclooxygenase-2 and 5-lipoxygenase pathways in diosgenin-induced apoptosis in HT-29 and HCT-116 colon cancer cells. Int J Oncol. 2010;36:1183-91 pubmed
    We studied the relationship between diosgenin-induced apoptosis and arachidonic acid metabolism in two cancer cell lines, the HT-29 and HCT-116...
  48. Tucci M, Benghuzzi H. Structural changes in the kidney associated with ovariectomy and diosgenin replacement therapy in adult female rats. Biomed Sci Instrum. 2003;39:341-6 pubmed
    ..The active ingredient in these preparations is the compound diosgenin. Diosgenin, which is synthetically derived from wild yams, is converted to human progesterone, aldosterone, ..
  49. Son I, Kim J, Sohn H, Son K, Kim J, Kwon C. Antioxidative and hypolipidemic effects of diosgenin, a steroidal saponin of yam (Dioscorea spp.), on high-cholesterol fed rats. Biosci Biotechnol Biochem. 2007;71:3063-71 pubmed
    b>Diosgenin (a steroidal saponin of yam) has long been used as a raw material for the industrial production of steroid drugs, and reported to have a hypocholesterolemic effect by suppressing cholesterol absorption and increasing ..
  50. Yang H, Chen B, Wang X, Chue P, Shen Y, Xia G, et al. Rapid quantitative analysis of diosgenin in the tubers of Dioscorea zingiberensis C.H. Wright by coupling cellulose enzymolysis and two-phase acid hydrolysis in tandem with HPLC-UV. Nat Prod Res. 2013;27:1933-5 pubmed publisher
    A rapid method was developed to quantify diosgenin in Rhizoma Dioscoreae Zingiberensis. For the first time, sample solution was prepared by coupling pretreatment of raw material in cellulase and two-phase acid hydrolysis...
  51. Kong M, Fan J, Dong A, Cheng H, Xu R. Effects of polyphyllin I on growth inhibition of human non-small lung cancer cells and in xenograft. Acta Biochim Biophys Sin (Shanghai). 2010;42:827-33 pubmed publisher
    ..PPI exhibits antitumor ability in NSCLC cells in vitro and in vivo, which might be related to the apoptosis induced by PPI. ..
  52. Wang L, Wang X, Yuan X, Zhao B. Simultaneous analysis of diosgenin and sarsasapogenin in Asparagus officinalis byproduct by thin-layer chromatography. Phytochem Anal. 2011;22:14-7 pubmed publisher
    ..Normally diosgenin and sarsasapogenin are analysed separately by thin-layer chromatography or high-performance liquid ..
  53. Li F, Fernandez P, Rajendran P, Hui K, Sethi G. Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells. Cancer Lett. 2010;292:197-207 pubmed publisher
    ..In the present report, we investigated whether diosgenin, a steroidal saponin isolated from fenugreek can modulate the STAT3 signaling pathway...