ergosterol

Summary

Summary: A steroid occurring in FUNGI. Irradiation with ULTRAVIOLET RAYS results in formation of ERGOCALCIFEROL (vitamin D2).

Top Publications

  1. Pinto E, Afonso C, Duarte S, Vale Silva L, Costa E, Sousa E, et al. Antifungal activity of xanthones: evaluation of their effect on ergosterol biosynthesis by high-performance liquid chromatography. Chem Biol Drug Des. 2011;77:212-22 pubmed publisher
    ..and efficient HPLC method with UV detection to study the effect of the active xanthones on the biosynthesis of ergosterol was developed and validated...
  2. Fang Y, Hu L, Zhou X, Jaiseng W, Zhang B, Takami T, et al. A genomewide screen in Schizosaccharomyces pombe for genes affecting the sensitivity of antifungal drugs that target ergosterol biosynthesis. Antimicrob Agents Chemother. 2012;56:1949-59 pubmed publisher
    ..screen for altered sensitivity to antifungal drugs, including clotrimazole and terbinafine, that target ergosterol biosynthesis using a Schizosaccharomyces pombe gene deletion library consisting of 3,004 nonessential haploid ..
  3. Hata M, Ishii Y, Watanabe E, Uoto K, Kobayashi S, Yoshida K, et al. Inhibition of ergosterol synthesis by novel antifungal compounds targeting C-14 reductase. Med Mycol. 2010;48:613-21 pubmed publisher
    ..of the extracted non-saponifiable lipids from Candida albicans showed that these compounds inhibited the ergosterol production in the late step of the synthesis pathway...
  4. Yan G, Wen K, Duan C. Enhancement of ?-carotene production by over-expression of HMG-CoA reductase coupled with addition of ergosterol biosynthesis inhibitors in recombinant Saccharomyces cerevisiae. Curr Microbiol. 2012;64:159-63 pubmed publisher
    ..effect of overexpressing the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase gene and adding ergosterol synthesis inhibitor, ketoconazole, on ?-carotene production in the recombinant Saccharomyces cerevisiae was ..
  5. Vanegas J, Contreras M, Faller R, Longo M. Role of unsaturated lipid and ergosterol in ethanol tolerance of model yeast biomembranes. Biophys J. 2012;102:507-16 pubmed publisher
    ..a ternary supported lipid bilayer system containing a saturated lipid (DPPC), an unsaturated lipid (DOPC), and ergosterol in the presence of high ethanol (20 vol %)...
  6. Endo A, Nakamura T, Shima J. Involvement of ergosterol in tolerance to vanillin, a potential inhibitor of bioethanol fermentation, in Saccharomyces cerevisiae. FEMS Microbiol Lett. 2009;299:95-9 pubmed publisher
    A vanillin-tolerant strain of Saccharomyces cerevisiae was screened and its intracellular ergosterol levels were compared with several laboratory yeast strains to study the potential relationship between ergosterol content and vanillin ..
  7. Gray K, Palacios D, Dailey I, Endo M, Uno B, Wilcock B, et al. Amphotericin primarily kills yeast by simply binding ergosterol. Proc Natl Acad Sci U S A. 2012;109:2234-9 pubmed publisher
    ..Alternatively, AmB primarily kills yeast by simply binding ergosterol, a lipid that is vital for many aspects of yeast cell physiology...
  8. Cresnar B, Petric S. Cytochrome P450 enzymes in the fungal kingdom. Biochim Biophys Acta. 2011;1814:29-35 pubmed publisher
  9. Umegawa Y, Nakagawa Y, Tahara K, Tsuchikawa H, Matsumori N, Oishi T, et al. Head-to-tail interaction between amphotericin B and ergosterol occurs in hydrated phospholipid membrane. Biochemistry. 2012;51:83-9 pubmed publisher
    ..B (AmB) is thought to exert its antifungal activity by forming an ion-channel assembly in the presence of ergosterol. In the present study we aimed to elucidate the mode of molecular interactions between AmB and ergosterol in ..

More Information

Publications62

  1. Poole J, Dooley G, Saito R, Burrell A, BAILEY K, Romberger D, et al. Muramic acid, endotoxin, 3-hydroxy fatty acids, and ergosterol content explain monocyte and epithelial cell inflammatory responses to agricultural dusts. J Toxicol Environ Health A. 2010;73:684-700 pubmed publisher
    ..was to determine the distribution of microbial endotoxin, 3-hydroxy fatty acids (3-OHFA), muramic acid, and ergosterol and evaluate inflammatory responses in human monocytes and bronchial epithelial cells with various dust samples...
  2. Russo A, Cardile V, Piovano M, Caggia S, Espinoza C, Garbarino J. Pro-apoptotic activity of ergosterol peroxide and (22E)-ergosta-7,22-dien-5alpha-hydroxy-3,6-dione in human prostate cancer cells. Chem Biol Interact. 2010;184:352-8 pubmed publisher
    ..novel agents with antigrowth and pro-apoptotic activity on prostate cancer cells, we assayed the effect of ergosterol peroxide and (22E)-ergosta-7,22-dien-5alpha-hydroxy-3,6-dione, a semisynthetic compound, against androgen-..
  3. Georgiev A, Sullivan D, Kersting M, Dittman J, Beh C, Menon A. Osh proteins regulate membrane sterol organization but are not required for sterol movement between the ER and PM. Traffic. 2011;12:1341-55 pubmed publisher
    ..In a second approach we used a pulse-chase protocol to analyze the movement of metabolically radiolabeled ergosterol from the ER to the PM...
  4. Nagi M, Nakayama H, Tanabe K, Bard M, Aoyama T, Okano M, et al. Transcription factors CgUPC2A and CgUPC2B regulate ergosterol biosynthetic genes in Candida glabrata. Genes Cells. 2011;16:80-9 pubmed publisher
    Zn[2]-Cys[6] binuclear transcription factors Upc2p and Ecm22p regulate the expression of genes involved in ergosterol biosynthesis and exogenous sterol uptake in Saccharomyces cerevisiae...
  5. Montañés F, Pascual Ahuir A, Proft M. Repression of ergosterol biosynthesis is essential for stress resistance and is mediated by the Hog1 MAP kinase and the Mot3 and Rox1 transcription factors. Mol Microbiol. 2011;79:1008-23 pubmed publisher
    ..determinant of osmostress tolerance, which involves the Hog1-dependent transcriptional downregulation of ergosterol biosynthesis genes (ERG). Yeast cells considerably lower their sterol content in response to high osmolarity...
  6. Palacios D, Dailey I, Siebert D, Wilcock B, Burke M. Synthesis-enabled functional group deletions reveal key underpinnings of amphotericin B ion channel and antifungal activities. Proc Natl Acad Sci U S A. 2011;108:6733-8 pubmed publisher
    ..the mycosamine sugar is strictly required for promoting a direct binding interaction between amphotericin B and ergosterol. The same is true for cholesterol...
  7. Henderson C, Lozada Contreras M, Naravane Y, Longo M, Block D. Analysis of major phospholipid species and ergosterol in fermenting industrial yeast strains using atmospheric pressure ionization ion-trap mass spectrometry. J Agric Food Chem. 2011;59:12761-70 pubmed publisher
    ..atmospheric pressure ionization-ion-trap mass spectrometry methods to quantitatively determine phospholipid and ergosterol levels at numerous fermentation time points...
  8. Gamarra S, Rocha E, Zhang Y, Park S, Rao R, Perlin D. Mechanism of the synergistic effect of amiodarone and fluconazole in Candida albicans. Antimicrob Agents Chemother. 2010;54:1753-61 pubmed publisher
    ..As expected, fluconazole induces an increase in ergosterol pathway genes expression levels...
  9. Brumfield K, Moroney J, Moore T, Simms T, Donze D. Functional characterization of the Chlamydomonas reinhardtii ERG3 ortholog, a gene involved in the biosynthesis of ergosterol. PLoS ONE. 2010;5:e8659 pubmed publisher
    The predominant sterol in the membranes of the alga Chlamydomonas reinhardtii is ergosterol, which is commonly found in the membranes of fungi, but is rarely found in higher plants...
  10. Blatzer M, Barker B, Willger S, Beckmann N, Blosser S, Cornish E, et al. SREBP coordinates iron and ergosterol homeostasis to mediate triazole drug and hypoxia responses in the human fungal pathogen Aspergillus fumigatus. PLoS Genet. 2011;7:e1002374 pubmed publisher
    ..srbA background was able to partially rescue the hypoxia growth, triazole drug susceptibility, and decrease in ergosterol content phenotypes of ?srbA...
  11. Ahmad A, Khan A, Manzoor N, Khan L. Evolution of ergosterol biosynthesis inhibitors as fungicidal against Candida. Microb Pathog. 2010;48:35-41 pubmed publisher
    Azoles target the ergosterol synthesizing enzyme lanosterol 14alpha-demethylase and are a widely applied class of antifungal agents...
  12. Alvarez Vasquez F, Riezman H, Hannun Y, Voit E. Mathematical modeling and validation of the ergosterol pathway in Saccharomyces cerevisiae. PLoS ONE. 2011;6:e28344 pubmed publisher
    The de novo biosynthetic machinery for both sphingolipid and ergosterol production in yeast is localized in the endoplasmic reticulum (ER) and Golgi...
  13. Pinto E, Vale Silva L, Cavaleiro C, Salgueiro L. Antifungal activity of the clove essential oil from Syzygium aromaticum on Candida, Aspergillus and dermatophyte species. J Med Microbiol. 2009;58:1454-62 pubmed publisher
    ..To clarify its mechanism of action on yeasts and filamentous fungi, flow cytometric and inhibition of ergosterol synthesis studies were performed...
  14. Spitzer M, Griffiths E, Blakely K, Wildenhain J, Ejim L, Rossi L, et al. Cross-species discovery of syncretic drug combinations that potentiate the antifungal fluconazole. Mol Syst Biol. 2011;7:499 pubmed publisher
    Resistance to widely used fungistatic drugs, particularly to the ergosterol biosynthesis inhibitor fluconazole, threatens millions of immunocompromised patients susceptible to invasive fungal infections...
  15. Sun X, Wang J, Feng D, Ma Z, Li H. PdCYP51B, a new putative sterol 14?-demethylase gene of Penicillium digitatum involved in resistance to imazalil and other fungicides inhibiting ergosterol synthesis. Appl Microbiol Biotechnol. 2011;91:1107-19 pubmed publisher
    ..digitatum. ..
  16. Dupont S, Lemetais G, Ferreira T, Cayot P, Gervais P, Beney L. Ergosterol biosynthesis: a fungal pathway for life on land?. Evolution. 2012;66:2961-8 pubmed publisher
    ..Here, we investigated the influence of the progression in the different steps of the ergosterol biosynthetic pathway (EBP) on the yeast resistance to transitions from aqueous to aerial media, typical ..
  17. Baran M, Borowski E, Mazerski J. Molecular modeling of amphotericin B-ergosterol primary complex in water II. Biophys Chem. 2009;141:162-8 pubmed publisher
    ..In contrast to the previously researched AmB-ergosterol binary complex, the AmB-ergosterol-AmB aggregates simulated of 2:1 stoichiometry retain significantly higher ..
  18. Porter J, Burg J, Espenshade P, Iglesias P. Ergosterol regulates sterol regulatory element binding protein (SREBP) cleavage in fission yeast. J Biol Chem. 2010;285:41051-61 pubmed publisher
    ..Here, we demonstrate that Sre1-Scp1 senses ergosterol. Processing experimental data with a mathematical model of Sre1 and Scp1 function reveals a clear quantitative ..
  19. Ahmad A, Khan A, Akhtar F, Yousuf S, Xess I, Khan L, et al. Fungicidal activity of thymol and carvacrol by disrupting ergosterol biosynthesis and membrane integrity against Candida. Eur J Clin Microbiol Infect Dis. 2011;30:41-50 pubmed publisher
    ..Insight into the mechanism of action was elucidated by flow cytometric analysis, confocal imaging and ergosterol biosynthesis studies...
  20. Liang R, Cao Y, Fan K, Xu Y, Gao P, Zhou Y, et al. 2-Amino-nonyl-6-methoxyl-tetralin muriate inhibits sterol C-14 reductase in the ergosterol biosynthetic pathway. Acta Pharmacol Sin. 2009;30:1709-16 pubmed publisher
    To investigate the action mechanism of a novel chemical structural aminotetralin derivate, 2-Amino-Nonyl-6-Methoxyl-Tetralin Muriate (10b), against Candida albicans (C albicans) in the ergosterol biosynthetic pathway.
  21. Dovbnya D, Egorova O, Donova M. Microbial side-chain degradation of ergosterol and its 3-substituted derivatives: a new route for obtaining of deltanoids. Steroids. 2010;75:653-8 pubmed publisher
    The strain of Mycobacterium sp. VKM Ac-1815D was found to convert ergosterol and its 3-acetate mainly to androst-4-ene-3,17-dione (AD) thus demonstrating ability to reduce 7(8)-double bond and hydrolyze sterol ester in addition to ..
  22. Neumann A, Czub J, Baginski M. On the possibility of the amphotericin B-sterol complex formation in cholesterol- and ergosterol-containing lipid bilayers: a molecular dynamics study. J Phys Chem B. 2009;113:15875-85 pubmed publisher
    ..Therapeutic application of AmB is based on the fact that it is more active against ergosterol-containing membranes of fungal cells than against mammalian membranes with cholesterol...
  23. Miao L, Chi S, Tang Y, Su Z, Yin T, Guan G, et al. Astaxanthin biosynthesis is enhanced by high carotenogenic gene expression and decrease of fatty acids and ergosterol in a Phaffia rhodozyma mutant strain. FEMS Yeast Res. 2011;11:192-201 pubmed publisher
    ..Although fatty acid and total ergosterol content were reduced by 40-70 mg g(-1) and 760...
  24. Umegawa Y, Matsumori N, Oishi T, Murata M. Ergosterol increases the intermolecular distance of amphotericin B in the membrane-bound assembly as evidenced by solid-state NMR. Biochemistry. 2008;47:13463-9 pubmed publisher
    ..The REDOR results suggested that the intermolecular distance of AmB molecules is significantly increased in the ergosterol membrane as compared with the cholesterol membrane...
  25. Khan A, Ahmad A, Akhtar F, Yousuf S, Xess I, Khan L, et al. Ocimum sanctum essential oil and its active principles exert their antifungal activity by disrupting ergosterol biosynthesis and membrane integrity. Res Microbiol. 2010;161:816-23 pubmed publisher
    ..their effect on the plasma membrane using flow cytometry, confocal imaging and determination of the levels of ergosterol, a fungal-specific sterol...
  26. Gomez Lopez A, Buitrago M, Rodriguez Tudela J, Cuenca Estrella M. In vitro antifungal susceptibility pattern and ergosterol content in clinical yeast strains. Rev Iberoam Micol. 2011;28:100-3 pubmed publisher
    Absence or severe reduction in the amount of ergosterol in the fungal membrane and its replacement with other sterols have been described as potential antifungal resistance mechanisms in fungi...
  27. Misra L, Mishra P, Pandey A, Sangwan R, Sangwan N. 1,4-Dioxane and ergosterol derivatives from Withania somnifera roots. J Asian Nat Prod Res. 2012;14:39-45 pubmed publisher
    ..oleic and stearic fatty acids, stigmasterone, stigmasterol, sitostanone, oleanolic acid along with the ergosterol and 1,4-dioxane derivatives as new compounds...
  28. Dohnal V, Jezkova A, Pavlikova L, Musilek K, Jun D, Kuca K. Fluctuation in the ergosterol and deoxynivalenol content in barley and malt during malting process. Anal Bioanal Chem. 2010;397:109-114 pubmed publisher
    This paper describes determination of the deoxynivalenol and ergosterol in samples from different varieties of barley and, consequently, malt produced from this barley...
  29. Simova Z, Poloncova K, Tahotna D, Holic R, Hapala I, Smith A, et al. The yeast Saccharomyces cerevisiae Pdr16p restricts changes in ergosterol biosynthesis caused by the presence of azole antifungals. Yeast. 2013;30:229-41 pubmed publisher
    ..Based on these observations, we propose a hypothesis that Pdr16p assists in shuttling sterols or their intermediates between membranes or, alternatively, between sterol biosynthetic enzymes or complexes. ..
  30. Kang C, Yamada K, Usuki Y, Ogita A, Fujita K, Tanaka T. Visualization analysis of the vacuole-targeting fungicidal activity of amphotericin B against the parent strain and an ergosterol-less mutant of Saccharomyces cerevisiae. Microbiology. 2013;159:939-47 pubmed publisher
    ..cerevisiae. Indifference was observed only with ?erg3 cells, indicating that the replacement of ergosterol with episterol facilitated their resistance to the combined lethal actions of AmB and MC12...
  31. Klemm R, Ejsing C, Surma M, Kaiser H, Gerl M, Sampaio J, et al. Segregation of sphingolipids and sterols during formation of secretory vesicles at the trans-Golgi network. J Cell Biol. 2009;185:601-12 pubmed publisher
    ..a novel quantitative shotgun lipidomics approach, we could demonstrate that TGN sorting selectively enriched ergosterol and sphingolipid species in the immunoisolated secretory vesicles...
  32. Liu J, Nes W. Steroidal triterpenes: design of substrate-based inhibitors of ergosterol and sitosterol synthesis. Molecules. 2009;14:4690-706 pubmed publisher
    ..The SMT catalyzes the C24-methylation reaction involved with the introduction of the C24-methyl group of ergosterol and the C24-ethyl group of sitosterol, cholesterol surrogates that function as essential membrane inserts in ..
  33. Souza C, Schwabe T, Pichler H, Ploier B, Leitner E, Guan X, et al. A stable yeast strain efficiently producing cholesterol instead of ergosterol is functional for tryptophan uptake, but not weak organic acid resistance. Metab Eng. 2011;13:555-69 pubmed publisher
    ..Both cholesterol and ergosterol can form liquid ordered domains in artificial membranes...
  34. Vatsa P, Chiltz A, Luini E, Vandelle E, Pugin A, Roblin G. Cytosolic calcium rises and related events in ergosterol-treated Nicotiana cells. Plant Physiol Biochem. 2011;49:764-73 pubmed publisher
    The typical fungal membrane component ergosterol was previously shown to trigger defence responses and protect plants against pathogens. Most of the elicitors mobilize the second messenger calcium, to trigger plant defences...
  35. Renard D, Perruchon J, Giera M, Müller J, Bracher F. Side chain azasteroids and thiasteroids as sterol methyltransferase inhibitors in ergosterol biosynthesis. Bioorg Med Chem. 2009;17:8123-37 pubmed publisher
    ..inhibitors of the enzyme Delta24-sterol methyltransferase (24-SMT), which is a key enzyme in the biosynthesis of ergosterol, and for their effects on the growth of the yeast Yarrowia lipolytica...
  36. Zhang Y, Gamarra S, Garcia Effron G, Park S, Perlin D, Rao R. Requirement for ergosterol in V-ATPase function underlies antifungal activity of azole drugs. PLoS Pathog. 2010;6:e1000939 pubmed publisher
    b>Ergosterol is an important constituent of fungal membranes. Azoles inhibit ergosterol biosynthesis, although the cellular basis for their antifungal activity is not understood...
  37. Liu J, Zhu Y, Du G, Zhou J, Chen J. Exogenous ergosterol protects Saccharomyces cerevisiae from D-limonene stress. J Appl Microbiol. 2013;114:482-91 pubmed publisher
    ..The aims of the current work are to demonstrate the mechanisms by which ergosterol, an important component of cell membranes, protects S...
  38. Baumann K, Adelantado N, Lang C, Mattanovich D, Ferrer P. Protein trafficking, ergosterol biosynthesis and membrane physics impact recombinant protein secretion in Pichia pastoris. Microb Cell Fact. 2011;10:93 pubmed publisher
    ..Transcriptional analysis and data mining allowed for the selection of potential targets for strain improvement. A first selection of these candidates has been evaluated as recombinant protein secretion enhancers...
  39. te Welscher Y, Jones L, van Leeuwen M, Dijksterhuis J, de Kruijff B, Eitzen G, et al. Natamycin inhibits vacuole fusion at the priming phase via a specific interaction with ergosterol. Antimicrob Agents Chemother. 2010;54:2618-25 pubmed publisher
    ..Its antifungal activity arises via a specific interaction with ergosterol in the plasma membrane (te Welscher et al., J. Biol. Chem. 283:6393-6401, 2008)...
  40. Zhang Y, Rao R. Beyond ergosterol: linking pH to antifungal mechanisms. Virulence. 2010;1:551-4 pubmed
    Many antifungal drugs including the highly successful azoles target the fungal-specific sterol, ergosterol, yet the molecular identity of cellular pathways mediating antifungal activity remained obscure...
  41. Ding J, Huang X, Zhang L, Zhao N, Yang D, Zhang K. Tolerance and stress response to ethanol in the yeast Saccharomyces cerevisiae. Appl Microbiol Biotechnol. 2009;85:253-63 pubmed publisher
    ..Here, we review the recent progresses in our understanding of ethanol resistance and stress responses in yeast. ..
  42. Miller M, Haubrich B, Wang Q, Snell W, Nes W. Evolutionarily conserved Delta(25(27))-olefin ergosterol biosynthesis pathway in the alga Chlamydomonas reinhardtii. J Lipid Res. 2012;53:1636-45 pubmed publisher
    b>Ergosterol is the predominant sterol of fungi and green algae...
  43. Hull C, Parker J, Bader O, Weig M, Gross U, Warrilow A, et al. Facultative sterol uptake in an ergosterol-deficient clinical isolate of Candida glabrata harboring a missense mutation in ERG11 and exhibiting cross-resistance to azoles and amphotericin B. Antimicrob Agents Chemother. 2012;56:4223-32 pubmed publisher
    ..glabrata Erg11p fully complemented the function of S. cerevisiae sterol 14?-demethylase, restoring growth and ergosterol synthesis in recombinant yeast; mutated CG156 Erg11p did not...
  44. Shao S, Hernandez M, Kramer J, Rinker D, Tsao R. Ergosterol profiles, fatty acid composition, and antioxidant activities of button mushrooms as affected by tissue part and developmental stage. J Agric Food Chem. 2010;58:11616-25 pubmed publisher
    ..We found that only free ergosterols were present in both mushrooms at 2.04-4.82 mg/g dry matter (DM). Ergosterol concentration was higher in early growth stages but decreased as the mushrooms grew, and it distributed evenly ..
  45. Zhao J, Lin W, Ma X, Lu Q, Ma X, Bian G, et al. The protein kinase Hal5p is the high-copy suppressor of lithium-sensitive mutations of genes involved in the sporulation and meiosis as well as the ergosterol biosynthesis in Saccharomyces cerevisiae. Genomics. 2010;95:290-8 pubmed publisher
    ..lithium-sensitive mutations of genes involved in the sporulation and meiosis as well as in the biosynthesis of ergosterol. These results suggest that Hal5p-mediated ion homeostasis is important for these two biological processes.
  46. Wu Q, Xie Y, Deng Z, Li X, Yang W, Jiao C, et al. Ergosterol peroxide isolated from Ganoderma lucidum abolishes microRNA miR-378-mediated tumor cells on chemoresistance. PLoS ONE. 2012;7:e44579 pubmed publisher
    ..We purified and identified the biologically active component of Ganoderma lucidum as ergosterol peroxide...
  47. Kasai Y, Matsumori N, Ueno H, Nonomura K, Yano S, Michio M, et al. Synthesis of 6-F-ergosterol and its influence on membrane-permeabilization of amphotericin B and amphidinol 3. Org Biomol Chem. 2011;9:1437-42 pubmed publisher
    ..investigation of the molecular recognition underlying their potent antifungal activity, we synthesized 6-fluoro-ergosterol in five steps via ring opening of (5?,6?)-epoxide of ergosterol acetate with using novel combination of TiF(4) ..
  48. Krumpe K, Frumkin I, Herzig Y, Rimon N, Ozbalci C, Brugger B, et al. Ergosterol content specifies targeting of tail-anchored proteins to mitochondrial outer membranes. Mol Biol Cell. 2012;23:3927-35 pubmed publisher
    ..We found that ER membranes in spf1 cells become similar in their ergosterol content to mitochondrial membranes...
  49. Kalaras M, Beelman R, Holick M, Elias R. Generation of potentially bioactive ergosterol-derived products following pulsed ultraviolet light exposure of mushrooms (Agaricus bisporus). Food Chem. 2012;135:396-401 pubmed publisher
    The production of vitamin D(2) from ergosterol in mushrooms upon exposure to ultraviolet (UV) irradiation has been well established in recent years...
  50. Mannock D, Lewis R, McElhaney R. A calorimetric and spectroscopic comparison of the effects of ergosterol and cholesterol on the thermotropic phase behavior and organization of dipalmitoylphosphatidylcholine bilayer membranes. Biochim Biophys Acta. 2010;1798:376-88 pubmed publisher
    We performed comparative DSC and FTIR spectroscopic measurements of the effects of cholesterol (Chol) and ergosterol (Erg) on the thermotropic phase behavior and organization of DPPC bilayers...
  51. Yasmin S, Alcazar Fuoli L, Gründlinger M, Puempel T, Cairns T, Blatzer M, et al. Mevalonate governs interdependency of ergosterol and siderophore biosyntheses in the fungal pathogen Aspergillus fumigatus. Proc Natl Acad Sci U S A. 2012;109:E497-504 pubmed publisher
    ..Here we demonstrate a link between TAFC and ergosterol biosynthetic pathways, which are both critical for virulence and treatment of fungal infections...
  52. Marisco G, Saito S, Ganda I, Brendel M, Pungartnik C. Low ergosterol content in yeast adh1 mutant enhances chitin maldistribution and sensitivity to paraquat-induced oxidative stress. Yeast. 2011;28:363-73 pubmed publisher
    ..analyses of both LOG and stationary-phase cells showed that adh1? mutant contained significantly less ergosterol than cells of WT and adh2? mutant, whereas the erg3? mutant contained extremely low ergosterol pools...
  53. Müller C, Staudacher V, Krauss J, Giera M, Bracher F. A convenient cellular assay for the identification of the molecular target of ergosterol biosynthesis inhibitors and quantification of their effects on total ergosterol biosynthesis. Steroids. 2013;78:483-93 pubmed publisher
    ..In the search for new antifungals ergosterol biosynthesis still is the most prominent target...