fusidic acid

Summary

Summary: An antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed). It acts by inhibiting translocation during protein synthesis.

Top Publications

  1. Christiansen K. Fusidic acid adverse drug reactions. Int J Antimicrob Agents. 1999;12 Suppl 2:S3-9 pubmed
    Unlike trials conducted today on new antimicrobials, the introduction of fusidic acid was not accompanied by extensive studies on toxicity and side effects...
  2. Chen Y, Koripella R, Sanyal S, Selmer M. Staphylococcus aureus elongation factor G--structure and analysis of a target for fusidic acid. FEBS J. 2010;277:3789-803 pubmed publisher
    b>Fusidic acid (FA) is a bacteriostatic antibiotic that locks elongation factor G (EF-G) on the ribosome in a post-translocational state...
  3. Besier S, Ludwig A, Brade V, Wichelhaus T. Compensatory adaptation to the loss of biological fitness associated with acquisition of fusidic acid resistance in Staphylococcus aureus. Antimicrob Agents Chemother. 2005;49:1426-31 pubmed
    Recent studies have shown that individual amino acid exchanges within elongation factor G (EF-G) cause fusidic acid resistance in Staphylococcus aureus...
  4. Gao Y, Selmer M, Dunham C, Weixlbaumer A, Kelley A, Ramakrishnan V. The structure of the ribosome with elongation factor G trapped in the posttranslocational state. Science. 2009;326:694-9 pubmed publisher
    ..6 angstrom resolution of the ribosome trapped with EF-G in the posttranslocational state using the antibiotic fusidic acid. Fusidic acid traps EF-G in a conformation intermediate between the guanosine triphosphate and guanosine ..
  5. Dobie D, Gray J. Fusidic acid resistance in Staphylococcus aureus. Arch Dis Child. 2004;89:74-7 pubmed
    This review summarises current knowledge of the microbiological and clinical aspects of fusidic acid resistance in Staphylococcus aureus, and makes recommendations about fusidic acid prescribing and further research.
  6. O Neill A, Cove J, Chopra I. Mutation frequencies for resistance to fusidic acid and rifampicin in Staphylococcus aureus. J Antimicrob Chemother. 2001;47:647-50 pubmed
    Frequencies at which mutants resistant to fusidic acid and/or rifampicin arose in vitro were determined in Staphylococcus aureus strains including methicillin-susceptible S. aureus (MSSA), methicillin-resistant S...
  7. Duvold T, Sørensen M, Bjorkling F, Henriksen A, Rastrup Andersen N. Synthesis and conformational analysis of fusidic acid side chain derivatives in relation to antibacterial activity. J Med Chem. 2001;44:3125-31 pubmed
    Novel fusidic acid type antibiotics having flexible side chains are described. Saturation of the double bond between C-17 and C-20 of fusidic acid produces four stereoisomers differing in the configuration at C-17 and C-20...
  8. Yang C, Plackett D, Needham D, Burt H. PLGA and PHBV microsphere formulations and solid-state characterization: possible implications for local delivery of fusidic acid for the treatment and prevention of orthopaedic infections. Pharm Res. 2009;26:1644-56 pubmed publisher
    ..acid-co-3-hydroxyvaleric acid) (PHBV) microspheres for the localized and controlled release of fusidic acid (FA)...
  9. Noren T, Wullt M, Akerlund T, Back E, Odenholt I, Burman L. Frequent emergence of resistance in Clostridium difficile during treatment of C. difficile-associated diarrhea with fusidic acid. Antimicrob Agents Chemother. 2006;50:3028-32 pubmed
    Samples from patients with Clostridium difficile-associated diarrhea (CDAD) that were randomized to fusidic acid (n = 59) or metronidazole (n = 55) therapy for 7 days were cultured for Clostridium difficile in feces on days 1, 8 to 13, ..

More Information

Publications62

  1. Biedenbach D, Rhomberg P, Mendes R, Jones R. Spectrum of activity, mutation rates, synergistic interactions, and the effects of pH and serum proteins for fusidic acid (CEM-102). Diagn Microbiol Infect Dis. 2010;66:301-7 pubmed publisher
    b>Fusidic acid (CEM-102) is a steroidal antimicrobial agent with focused Gram-positive activity that acts by preventing bacterial protein synthesis via interacting with elongation factor G...
  2. Macvanin M, Björkman J, Eriksson S, Rhen M, Andersson D, Hughes D. Fusidic acid-resistant mutants of Salmonella enterica serovar Typhimurium with low fitness in vivo are defective in RpoS induction. Antimicrob Agents Chemother. 2003;47:3743-9 pubmed
    Mutants of Salmonella enterica serovar Typhimurium resistant to fusidic acid (Fusr) have mutations in fusA, the gene encoding translation elongation factor G (EF-G)...
  3. Filippi L, Pezzati M, Di Amario S, Poggi C, Pecile P. Fusidic acid and heparin lock solution for the prevention of catheter-related bloodstream infections in critically ill neonates: a retrospective study and a prospective, randomized trial. Pediatr Crit Care Med. 2007;8:556-62 pubmed
    ..The objective of the present study was to assess the efficacy of a fusidic acid-heparin lock in the prevention of CRBSIs...
  4. Muhonen J, Vidgren J, Helle A, Yohannes G, Viitala T, Holopainen J, et al. Interactions of fusidic acid and elongation factor G with lipid membranes. Anal Biochem. 2008;374:133-42 pubmed
    b>Fusidic acid (FA) is a potent antibiotic and blocks the protein synthesis by binding to elongation factor G (EF-G) directly...
  5. Woodford N, Afzal Shah M, Warner M, Livermore D. In vitro activity of retapamulin against Staphylococcus aureus isolates resistant to fusidic acid and mupirocin. J Antimicrob Chemother. 2008;62:766-8 pubmed publisher
    ..pleuromutilin antibiotic, against 664 Staphylococcus aureus isolates from the UK, including many resistant to fusidic acid and/or highly resistant to mupirocin...
  6. Jackson W, Low D, Dattani D, Whitsitt P, Leeder R, MacDougall R. Treatment of acute bacterial conjunctivitis: 1% fusidic acid viscous drops vs. 0.3% tobramycin drops. Can J Ophthalmol. 2002;37:228-37; discussion 237 pubmed
    ..The authors compared the clinical and microbiologic efficacy, safety and acceptability of 1% fusidic acid viscous drops (Fucithalmic) with 0...
  7. Qin L, Li B, Guan J, Zhang G. In vitro synergistic antibacterial activities of helvolic acid on multi-drug resistant Staphylococcus aureus. Nat Prod Res. 2009;23:309-18 pubmed publisher
    ..aureus. A pattern of enhanced killing was also found in time-kill studies on multi-drug resistant S. aureus. ..
  8. Turnidge J, Collignon P. Resistance to fusidic acid. Int J Antimicrob Agents. 1999;12 Suppl 2:S35-44 pubmed
    Resistance to fusidic acid is determined by a number of mechanisms...
  9. McLaws F, Chopra I, O Neill A. High prevalence of resistance to fusidic acid in clinical isolates of Staphylococcus epidermidis. J Antimicrob Chemother. 2008;61:1040-3 pubmed publisher
    To determine the prevalence and mechanisms of resistance to fusidic acid in clinical isolates of Staphylococcus epidermidis. MICs of fusidic acid were determined for S...
  10. Seo H, Abedin S, Kamp D, Wilson D, Nierhaus K, Cooperman B. EF-G-dependent GTPase on the ribosome. conformational change and fusidic acid inhibition. Biochemistry. 2006;45:2504-14 pubmed
    ..during single-turnover EF-G-dependent GTPase on vacant ribosomes and to elucidate the mechanism by which fusidic acid (FA) inhibits multiple-turnover EF-G.GTPase...
  11. Besier S, Ludwig A, Brade V, Wichelhaus T. Molecular analysis of fusidic acid resistance in Staphylococcus aureus. Mol Microbiol. 2003;47:463-9 pubmed
    b>Fusidic acid is a potent antibiotic against severe Gram-positive infections that interferes with the function of elongation factor G (EF-G), thereby leading to the inhibition of bacterial protein synthesis...
  12. Nagaev I, Bjorkman J, Andersson D, Hughes D. Biological cost and compensatory evolution in fusidic acid-resistant Staphylococcus aureus. Mol Microbiol. 2001;40:433-9 pubmed
    b>Fusidic acid resistance resulting from mutations in elongation factor G (EF-G) of Staphylococcus aureus is associated with fitness costs during growth in vivo and in vitro...
  13. Wullt M, Odenholt I. A double-blind randomized controlled trial of fusidic acid and metronidazole for treatment of an initial episode of Clostridium difficile-associated diarrhoea. J Antimicrob Chemother. 2004;54:211-6 pubmed
    ..A prospective, randomized controlled, double-blind trial was conducted to compare the efficacy of fusidic acid and metronidazole for treatment of patients experiencing a first episode of CDAD...
  14. Wenisch C, Parschalk B, Hasenhündl M, Hirschl A, Graninger W. Comparison of vancomycin, teicoplanin, metronidazole, and fusidic acid for the treatment of Clostridium difficile-associated diarrhea. Clin Infect Dis. 1996;22:813-8 pubmed
    We conducted a prospective, randomized study to compare the efficacy of oral fusidic acid, oral metronidazole, oral vancomycin, and oral teicoplanin for the treatment of Clostridium difficile-associated diarrhea...
  15. El Zimaity D, Kearns A, Dawson S, Price S, Harrison G. Survey, characterization and susceptibility to fusidic acid of Staphylococcus aureus in the Carmarthen area. J Antimicrob Chemother. 2004;54:441-6 pubmed
    This retrospective study was designed to investigate the possible reasons for an apparent increase in fusidic acid resistance among Staphylococcus aureus...
  16. Osterlund A, Kahlmeter G, Haeggman S, Olsson Liljequist B. Staphylococcus aureus resistant to fusidic acid among Swedish children: a follow-up study. Scand J Infect Dis. 2006;38:334-4 pubmed
    We previously described the epidemic spread of a fusidic acid resistant clone of Staphylococcus aureus among children with bullous impetigo throughout Sweden 1...
  17. Saruya K, Fukuda H, Saito R, Urushibata O, Mukai H. Plasmocytosis circumorificialis successfully treated with topical fusidic acid ointment. J Dermatol. 2009;36:232-6 pubmed publisher
    ..His eruption healed approximately 3 weeks after the start of this treatment. We report this case and discuss the findings reported in Japan on the development of plasmocytosis circumorificialis of the lips. ..
  18. Laurberg M, Kristensen O, Martemyanov K, Gudkov A, Nagaev I, Hughes D, et al. Structure of a mutant EF-G reveals domain III and possibly the fusidic acid binding site. J Mol Biol. 2000;303:593-603 pubmed publisher
    ..A large number of fusidic acid resistant mutations found in domain III have now been possible to locate...
  19. Hageman I, Buschard K. Antidiabetogenic effect of fusidic acid in diabetes prone BB rats: a sex-dependent organ accumulation of the drug is seen. Pharmacol Toxicol. 2002;91:123-8 pubmed
    b>Fusidic acid and its sodium salt (fusidin) are widely used antistaphylococcal drugs which possesses immunomodulatory properties...
  20. Larsen A, Skov R, Jarlier V, Henriksen A. Epidemiological differences between the UK and Ireland versus France in Staphylococcus aureus isolates resistant to fusidic acid from community-acquired skin and soft tissue infections. J Antimicrob Chemother. 2008;61:589-94 pubmed publisher
    To characterize the epidemiology of Staphylococcus aureus isolates resistant to fusidic acid isolated from patients with skin and soft tissue infections (SSTIs) in France, the UK and Ireland. One hundred and thirty-six S...
  21. O Neill A, Larsen A, Skov R, Henriksen A, Chopra I. Characterization of the epidemic European fusidic acid-resistant impetigo clone of Staphylococcus aureus. J Clin Microbiol. 2007;45:1505-10 pubmed publisher
    Resistance to the antibiotic fusidic acid in European strains of Staphylococcus aureus causing impetigo has increased in recent years...
  22. Lodeiro S, Xiong Q, Wilson W, Ivanova Y, Smith M, May G, et al. Protostadienol biosynthesis and metabolism in the pathogenic fungus Aspergillus fumigatus. Org Lett. 2009;11:1241-4 pubmed publisher
    ..Evidence regarding the evolutionary origin and taxonomic distribution of fusidane biosynthesis is also presented. ..
  23. Zhao J, Mou Y, Shan T, Li Y, Zhou L, Wang M, et al. Antimicrobial metabolites from the endophytic fungus Pichia guilliermondii isolated from Paris polyphylla var. yunnanensis. Molecules. 2010;15:7961-70 pubmed publisher
    ..The results suggest that the endophytic fungus Pichia guillermondii Ppf9 could be a candidate for producing helvolic acid, and the metabolites from this fungus could be potentially developed as antimicrobial agents in the future. ..
  24. Rietveld R, Ter Riet G, Bindels P, Bink D, Sloos J, van Weert H. The treatment of acute infectious conjunctivitis with fusidic acid: a randomised controlled trial. Br J Gen Pract. 2005;55:924-30 pubmed
    ..In The Netherlands, fusidic acid is most frequently prescribed.
  25. Shah M, Mohanraj M. High levels of fusidic acid-resistant Staphylococcus aureus in dermatology patients. Br J Dermatol. 2003;148:1018-20 pubmed
    ..To assess the level of fusidic acid-resistant Staphylococcus aureus inpatients with dermatological problems...
  26. McLaws F, Larsen A, Skov R, Chopra I, O Neill A. Distribution of fusidic acid resistance determinants in methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2011;55:1173-6 pubmed publisher
    The prevalence of resistance to fusidic acid in clinical isolates of Staphylococcus aureus, including methicillin-resistant S. aureus (MRSA), has increased in the past 2 decades...
  27. Lemaire S, Van Bambeke F, Pierard D, Appelbaum P, Tulkens P. Activity of fusidic acid against extracellular and intracellular Staphylococcus aureus: influence of pH and comparison with linezolid and clindamycin. Clin Infect Dis. 2011;52 Suppl 7:S493-503 pubmed publisher
    Emergence of multidrug-resistant Staphylococcus aureus has triggered a reassessment of fusidic acid (CEM-102, sodium fusidate). Fusidic acid was examined for (1) activity against recent methicillin-resistant S...
  28. Yazdankhah S, Asli A, Sørum H, Oppegaard H, Sunde M. Fusidic acid resistance, mediated by fusB, in bovine coagulase-negative staphylococci. J Antimicrob Chemother. 2006;58:1254-6 pubmed
    The aim of this study was to determine the occurrence of fusidic acid resistance, mediated by the fusB gene, among coagulase-negative staphylococci (CoNS) isolated from bovine mastitis...
  29. O Neill A, Chopra I. Molecular basis of fusB-mediated resistance to fusidic acid in Staphylococcus aureus. Mol Microbiol. 2006;59:664-76 pubmed publisher
    The primary mechanism of fusidic acid resistance in clinical strains of Staphylococcus aureus involves acquisition of the fusB determinant...
  30. Norazah A, Lim V, Koh Y, Rohani M, Zuridah H, Spencer K, et al. Molecular fingerprinting of fusidic acid- and rifampicin-resistant strains of methicillin-resistant Staphylococcus aureus (MRSA) from Malaysian hospitals. J Med Microbiol. 2002;51:1113-6 pubmed
    ..of multiresistant methicillin-resistant Staphylococcus aureus (MRSA) strains, especially those resistant to fusidic acid and rifampicin, in Malaysian hospitals is of concern...
  31. Tveten Y, Jenkins A, Kristiansen B. A fusidic acid-resistant clone of Staphylococcus aureus associated with impetigo bullosa is spreading in Norway. J Antimicrob Chemother. 2002;50:873-6 pubmed
    To investigate the possibility that the increased prevalence of fusidic acid-resistant Staphylococcus aureus in Norway is caused by clonal spread.
  32. Kanellakopoulou K, Sahinides T, Tsaganos T, Galanakis N, Giamarellou H, Giamarellos Bourboulis E. In vitro release of fusidic acid and teicoplanin from cancellous bone allografts. J Chemother. 2008;20:645-7 pubmed
    The characteristics of cancellous bone allografts as carriers of fusidic acid and teicoplanin are described...
  33. O Neill A, Bostock J, Moita A, Chopra I. Antimicrobial activity and mechanisms of resistance to cephalosporin P1, an antibiotic related to fusidic acid. J Antimicrob Chemother. 2002;50:839-48 pubmed
    The antimicrobial properties of cephalosporin P1, an antibiotic structurally related to fusidic acid, were examined. Cephalosporin P1 exhibited potent activity against methicillin-sensitive Staphylococcus aureus, methicillin-resistant S...
  34. Cox G, Thompson G, Jenkins H, Peske F, Savelsbergh A, Rodnina M, et al. Ribosome clearance by FusB-type proteins mediates resistance to the antibiotic fusidic acid. Proc Natl Acad Sci U S A. 2012;109:2102-7 pubmed publisher
    Resistance to the antibiotic fusidic acid (FA) in the human pathogen Staphylococcus aureus usually results from expression of FusB-type proteins (FusB or FusC)...
  35. Dominguez J, Gómez Lorenzo M, Martin J. Sordarin inhibits fungal protein synthesis by blocking translocation differently to fusidic acid. J Biol Chem. 1999;274:22423-7 pubmed
    ..These results were compared with those obtained with fusidic acid, showing that both drugs act in a different manner...
  36. Nielsen S, Black F. Extracellular and intracellular killing in neutrophil granulocytes of Staphylococcus aureus with rifampicin in combination with dicloxacillin or fusidic acid. J Antimicrob Chemother. 1999;43:407-10 pubmed
    The effect of rifampicin in combination with dicloxacillin or fusidic acid on the extracellular and intracellular killing of Staphylococcus aureus in human neutrophil granulocytes in the presence of serum was studied...
  37. Castanheira M, Watters A, Mendes R, Farrell D, Jones R. Occurrence and molecular characterization of fusidic acid resistance mechanisms among Staphylococcus spp. from European countries (2008). J Antimicrob Chemother. 2010;65:1353-8 pubmed publisher
    To determine fusidic acid resistance rates (MICs of > or = 2 mg/L) and the prevalence of fusidic acid resistance mechanisms among Staphylococcus spp. collected from European countries (2008)...
  38. Kimura M, Kushiro T, Shibuya M, Ebizuka Y, Abe I. Protostadienol synthase from Aspergillus fumigatus: functional conversion into lanosterol synthase. Biochem Biophys Res Commun. 2010;391:899-902 pubmed publisher
    ..Homology modeling suggested that stabilization of the C-20 protosteryl cation by the active-site Phe701 through cation-pi interactions is important for the product outcome between protostadienol and lanosterol. ..
  39. Guo X, Peisker K, Bäckbro K, Chen Y, Koripella R, Mandava C, et al. Structure and function of FusB: an elongation factor G-binding fusidic acid resistance protein active in ribosomal translocation and recycling. Open Biol. 2012;2:120016 pubmed publisher
    b>Fusidic acid (FA) is a bacteriostatic antibiotic that locks elongation factor G (EF-G) to the ribosome after GTP hydrolysis during elongation and ribosome recycling...
  40. Odenholt I, Walder M, Wullt M. Pharmacodynamic studies of vancomycin, metronidazole and fusidic acid against Clostridium difficile. Chemotherapy. 2007;53:267-74 pubmed
    ..the postantibiotic sub-minimum inhibitory concentration (MIC) effects (PA SME) of vancomycin, metronidazole and fusidic acid were investigated by viable counts against three different strains of C. difficile...
  41. O Neill A, McLaws F, Kahlmeter G, Henriksen A, Chopra I. Genetic basis of resistance to fusidic acid in staphylococci. Antimicrob Agents Chemother. 2007;51:1737-40 pubmed
    Resistance to fusidic acid in Staphylococcus aureus often results from acquisition of the fusB determinant or from mutations in the gene (fusA) that encodes the drug target (elongation factor G)...
  42. Apisarnthanarak A, Mundy L. Successful treatment of disseminated methicillin-resistant Staphylococcus aureus with fosfomycin, cefoperazone/sulbactam and rifampin followed by fusidic acid and rifampin. Int J Infect Dis. 2007;11:283-4 pubmed
  43. Macvanin M, Hughes D. Hyper-susceptibility of a fusidic acid-resistant mutant of Salmonella to different classes of antibiotics. FEMS Microbiol Lett. 2005;247:215-20 pubmed
    b>Fusidic acid resistance (Fus(R)) in Salmonella enterica serovar Typhimurium is caused by mutations in fusA, encoding elongation factor G (EF-G). Pleiotropic phenotypes are observed in Fus(R) mutants...
  44. Price C, Gustafson J. Increases in the mutation frequency at which fusidic acid-resistant Staphylococcus aureus arise with salicylate. J Med Microbiol. 2001;50:104-6 pubmed
    Salicylate was shown to increase the frequency at which a fusidic acid-susceptible strain of Staphylococcus aureus underwent mutation to become fusidic acid-resistant...
  45. Pradhan G, Agrawal J. Comparative study of post operative wound infection following emergency lower segment caesarean section with and without the topical use of fusidic acid. Nepal Med Coll J. 2009;11:189-91 pubmed
    ..to see the infection rate of wound following emergency caesarean section with and without the use of topical fusidic acid. The study was carried out at Himal Hospital from April 2006 to Jan. 2008...
  46. Farrell D, Robbins M, Rhys Williams W, Love W. Investigation of the potential for mutational resistance to XF-73, retapamulin, mupirocin, fusidic acid, daptomycin, and vancomycin in methicillin-resistant Staphylococcus aureus isolates during a 55-passage study. Antimicrob Agents Chemother. 2011;55:1177-81 pubmed publisher
    ..resistance selection studies in the presence of subinhibitory concentrations of XF-73, retapamulin, mupirocin, fusidic acid, and vancomycin against four Network on Antimicrobial Resistance in Staphylococcus aureus MRSA strains, there ..
  47. Craft J, Moriarty S, Clark K, Scott D, Degenhardt T, Still J, et al. A randomized, double-blind phase 2 study comparing the efficacy and safety of an oral fusidic acid loading-dose regimen to oral linezolid for the treatment of acute bacterial skin and skin structure infections. Clin Infect Dis. 2011;52 Suppl 7:S520-6 pubmed publisher
    b>Fusidic acid (CEM-102), an orally bioavailable fusidane antibiotic with a unique mode of action, is under development for treatment of acute gram-positive bacterial skin and skin structure infections, including those caused by methicillin-..
  48. Hunfeld K, Weigand J, Wichelhaus T, Kekoukh E, Kraiczy P, Brade V. In vitro activity of mezlocillin, meropenem, aztreonam, vancomycin, teicoplanin, ribostamycin and fusidic acid against Borrelia burgdorferi. Int J Antimicrob Agents. 2001;17:203-8 pubmed
    ..burgdorferi to mezlocillin, meropenem, aztreonam, vancomycin, teicoplanin, ribostamycin and fusidic acid. Minimal inhibitory concentrations (MICs) and minimal borreliacidal concentrations (MBCs) were measured using a ..
  49. Aboltins C, Page M, Buising K, Jenney A, Daffy J, Choong P, et al. Treatment of staphylococcal prosthetic joint infections with debridement, prosthesis retention and oral rifampicin and fusidic acid. Clin Microbiol Infect. 2007;13:586-91 pubmed
    ..who had been treated with surgical debridement and prosthesis retention, and a combination of rifampicin and fusidic acid were analysed. The mean duration of symptoms before initial debridement was 16 (range 2-75) days...
  50. Schöfer H, Simonsen L. Fusidic acid in dermatology: an updated review. Eur J Dermatol. 2010;20:6-15 pubmed publisher
    Studies on the clinical efficacy of fusidic acid in skin and soft-tissue infections (SSTIs), notably those due to Staphylococcus aureus, are reviewed...
  51. O Neill A, Larsen A, Henriksen A, Chopra I. A fusidic acid-resistant epidemic strain of Staphylococcus aureus carries the fusB determinant, whereas fusA mutations are prevalent in other resistant isolates. Antimicrob Agents Chemother. 2004;48:3594-7 pubmed
    b>Fusidic acid-resistant epidemic Staphylococcus aureus strains causing impetigo bullosa have been reported in Scandinavia. We show that these strains form part of a European epidemic clonotype that carries the fusB determinant...
  52. Grohs P, Kitzis M, Gutmann L. In vitro bactericidal activities of linezolid in combination with vancomycin, gentamicin, ciprofloxacin, fusidic acid, and rifampin against Staphylococcus aureus. Antimicrob Agents Chemother. 2003;47:418-20 pubmed
    ..activities of linezolid were determined alone and in combination with vancomycin, ciprofloxacin, gentamicin, fusidic acid, or rifampin against five methicillin-susceptible Staphylococcus aureus (MSSA) and five methicillin-resistant S...
  53. Osterlund A, Eden T, Olsson Liljequist B, Haeggman S, Kahlmeter G. Clonal spread among Swedish children of a Staphylococcus aureus strain resistant to fusidic acid. Scand J Infect Dis. 2002;34:729-34 pubmed
    An increased incidence of fusidic acid-resistant Staphylococcus aureus strains causing superficial infections among children in Sweden has been noted since the mid-1990s...