sodium cholate


Summary: A trihydroxy bile salt that is used as a digestive aid in dietary supplements. It is used in culture media and in conjunction with PAPAIN and PANCREATIN.

Top Publications

  1. Liu J, Gong T, Wang C, Zhong Z, Zhang Z. Solid lipid nanoparticles loaded with insulin by sodium cholate-phosphatidylcholine-based mixed micelles: preparation and characterization. Int J Pharm. 2007;340:153-62 pubmed
    ..insulin-mixed micelles (Ins-MMs) were prepared by a novel reverse micelle-double emulsion method, in which sodium cholate (SC) and soybean phosphatidylcholine (SPC) were employed to improve the liposolubility of insulin, and the ..
  2. Garidel P, Hildebrand A, Knauf K, Blume A. Membranolytic activity of bile salts: influence of biological membrane properties and composition. Molecules. 2007;12:2292-326 pubmed
    ..The interactions of two bile salt molecules, sodium cholate (NaC) and sodium deoxycholate (NaDC) with biological phospholipid model membranes are considered...
  3. Zhu Y, Yu J, Tong S, Wang L, Peng M, Cao X, et al. Preparation and in vitro evaluation of povidone-sodium cholate-phospholipid mixed micelles for the solubilization of poorly soluble drugs. Arch Pharm Res. 2010;33:911-7 pubmed publisher
    Mixed micelles made of polyvinylpyrrolidone (PVP), sodium cholate, and phospholipids were prepared to improve the solubility of poorly water-soluble drugs...
  4. Selvam S, Mishra A. Multiple prototropism of fisetin in sodium cholate and related bile salt media. Photochem Photobiol Sci. 2011;10:66-75 pubmed publisher
    ..The interaction of fisetin with sodium cholate (NaC) and some other bile salts has been studied in detail, using the intrinsic fluorescence of different ..
  5. Santos L, Rodrigues D, Lira M, Oliveira R, Real Oliveira M, Vilar E, et al. The effect of octylglucoside and sodium cholate in Staphylococcus epidermidis and Pseudomonas aeruginosa adhesion to soft contact lenses. Optom Vis Sci. 2007;84:429-34 pubmed
    In this study, the effect of the natural surfactants octylglucoside and sodium cholate in inhibiting Staphylococcus epidermidis and Pseudomonas aeruginosa adhesion to conventional and silicone-hydrogel contact lenses (CL) was assessed...
  6. Jeong W, Jeong D, Do S, Kim Y, Park H, Kwon O, et al. Mild hepatic fibrosis in cholesterol and sodium cholate diet-fed rats. J Vet Med Sci. 2005;67:235-42 pubmed
    ..Male Wistar rats were fed a diet supplemented with 1.0% cholesterol and 0.3% sodium cholate for 12 weeks...
  7. Yu J, Zhu Y, Wang L, Peng M, Tong S, Cao X, et al. Enhancement of oral bioavailability of the poorly water-soluble drug silybin by sodium cholate/phospholipid-mixed micelles. Acta Pharmacol Sin. 2010;31:759-64 pubmed publisher
    To evaluate a mixed micellar drug delivery system composed of sodium cholate and phospholipid for oral administration of silybin, a promising hepatoprotectants...
  8. Bojko M, Kruk J, Wieckowski S. Plastoquinones are effectively reduced by ferredoxin:NADP+ oxidoreductase in the presence of sodium cholate micelles. Significance for cyclic electron transport and chlororespiration. Phytochemistry. 2003;64:1055-60 pubmed
    The effect of sodium cholate and other detergents (Triton X-100, sodium dodecyl sulphate, octyl glucoside, myristyltrimethylammonium bromide) on the reduction of plastoquinones (PQ) with a different length of the side-chain by spinach ..
  9. Guo J, Wu T, Ping Q, Chen Y, Shen J, Jiang G. Solubilization and pharmacokinetic behaviors of sodium cholate/lecithin-mixed micelles containing cyclosporine A. Drug Deliv. 2005;12:35-9 pubmed
    The purpose of this study was to investigate the solubilization capacity of sodium cholate/lecithin-mixed micelles and to evaluate the potential of mixed micelles as a carrier of cyclosporine A for intravenous infusion...

More Information


  1. Alonso W, Trukawinski S, Savage M, Tenold R, Hammond D. Viral inactivation of intramuscular immune serum globulins. Biologicals. 2000;28:5-15 pubmed
    ..Taken together, these results indicate that the new products should have the same efficacy of the previous IGIM products albeit with safety and processing improvements. ..
  2. Terada M, Abe S, Akasaka T, Uo M, Kitagawa Y, Watari F. Development of a multiwalled carbon nanotube coated collagen dish. Dent Mater J. 2009;28:82-8 pubmed
    ..Carboxylated multiwalled carbon nanotubes (MWCNTs) were dispersed in aqueous sodium cholate solution and applied on a collagen type I-coated cell culture dish (cover glass)...
  3. Fukuoka S, Richter W, Howe J, Andrä J, Rössle M, Alexander C, et al. Biophysical investigations into the interactions of endotoxins with bile acids. Innate Immun. 2012;18:307-17 pubmed publisher
    ..These data imply that there are general mechanisms that govern the expression of biological activities of endotoxins. ..
  4. Higa L, Schilrreff P, Perez A, Iriarte M, Roncaglia D, Morilla M, et al. Ultradeformable archaeosomes as new topical adjuvants. Nanomedicine. 2012;8:1319-28 pubmed publisher
    Ultradeformable archaeosomes (UDA) are vesicles made of soybean phosphatidylcholine (SPC), sodium cholate (NaChol) and polar lipids from Halorubrum tebenquichense (3:1:3 wt/wt)...
  5. Intapan P, Maleewong W. In vitro excystation of Paragonimus heterotremus metacercariae. J Parasitol. 2001;87:1184-6 pubmed
    ..5-4 mM), and phenylmethylsulfonyl fluoride (1-4 mM). These results suggest that a number of extrinsic and intrinsic factors may modulate excystation...
  6. Srisawasdi P, Prasertsincharoen N, Kroll M. Porcine pancreas: a superior source of cholesterol esterase for total serum cholesterol assay by the enzymatic kinetic method. J Clin Lab Anal. 2012;26:420-30 pubmed publisher
    ..Optimization of four enzymes and effect of sodium cholate concentration were performed...
  7. Magg M, Kadria Vili Y, Oulevey P, Weisman R, Bürgi T. Resonance Raman Optical Activity Spectra of Single-Walled Carbon Nanotube Enantiomers. J Phys Chem Lett. 2016;7:221-5 pubmed publisher
    ..The obtained results are in good agreement with the single-excited-state theory (SES). To our knowledge, these are the first experimental VOA spectra of SWCNTs. ..
  8. Nishimura N, Umeda C, Oda H, Yokogoshi H. The effect of taurine on the cholesterol metabolism in rats fed diets supplemented with cholestyramine or high amounts of bile acid. J Nutr Sci Vitaminol (Tokyo). 2003;49:21-6 pubmed
    ..cholesterol 7alpha-hydroxylase activity (CYP7A1) were studied in rats fed cholestyramine or high amounts of sodium cholate in order to alter the intestinal pool of bile acids...
  9. Qiao Y, Chen H, Lin Y, Huang J. Controllable synthesis of water-soluble gold nanoparticles and their applications in electrocatalysis and surface-enhanced Raman scattering. Langmuir. 2011;27:11090-7 pubmed publisher
    We report a facile method to synthesize water-soluble gold nanoparticles (AuNPs) using a biosurfactant sodium cholate as reducing reagents and protective groups in aqueous solution at ambient temperature...
  10. Wu T, Guo J, Ping Q, Jin F, Sun X. [Transdermal delivery of cyclosporin A solubilized in mixed micelles through mice skin]. Yao Xue Xue Bao. 2001;36:381-5 pubmed
    ..In vivo study was carried out by topical application of sodium cholate-phospholipid mixed micelles onto the mice skin and drug blood concentration was detected...
  11. Mukherjee T, Squillantea E, Gillespieb M, Shao J. Transepithelial electrical resistance is not a reliable measurement of the Caco-2 monolayer integrity in Transwell. Drug Deliv. 2004;11:11-8 pubmed
    ..Four enhancers--disodium ethylenediaminetetracetate (disodium EDTA), sodium cholate (NaC), sodium taurocholate (NaTC), and sodium caprate along with alpha-hemolysin (a cell membrane pore-forming ..
  12. Annadhasan M, Sankarbabu V, Naresh R, Umamaheswari K, Rajendiran N. A sunlight-induced rapid synthesis of silver nanoparticles using sodium salt of N-cholyl amino acids and its antimicrobial applications. Colloids Surf B Biointerfaces. 2012;96:14-21 pubmed publisher
  13. Bottari E, Buonfigli A, Festa M. Composition of sodium cholate micellar solutions. Ann Chim. 2005;95:479-90 pubmed
    To study the composition of sodium cholate solutions, an investigation was carried out at 25 degrees C and in N(CH3)4Cl, as a constant ionic medium, at three different concentrations (W = 0.100; 0.500 and 0.800 mol dm(-3))...
  14. Lehnhardt F, Rohn G, Ernestus R, Grune M, Hoehn M. 1H- and (31)P-MR spectroscopy of primary and recurrent human brain tumors in vitro: malignancy-characteristic profiles of water soluble and lipophilic spectral components. NMR Biomed. 2001;14:307-17 pubmed
  15. Dalwadi G, Sunderland V. Purification of PEGylated nanoparticles using tangential flow filtration (TFF). Drug Dev Ind Pharm. 2007;33:1030-9 pubmed
    ..Two widely used surfactants, PVA and sodium cholate were efficiently removed from an empty nanoparticles suspension using the proposed system...
  16. Kurtovic I, Marshall S, Zhao X, Simpson B. Purification and properties of digestive lipases from Chinook salmon (Oncorhynchus tshawytscha) and New Zealand hoki (Macruronus novaezelandiae). Fish Physiol Biochem. 2010;36:1041-60 pubmed publisher
    ..Calcium ions and sodium cholate were absolutely necessary both for lipase stability in the gel and for optimum activity against caprate and ..
  17. Yañez F, Chianella I, Piletsky S, Concheiro A, Alvarez Lorenzo C. Computational modeling and molecular imprinting for the development of acrylic polymers with high affinity for bile salts. Anal Chim Acta. 2010;659:178-85 pubmed publisher
    ..without functional monomer, both imprinted and non-imprinted microparticles showed a high capability to remove sodium cholate from aqueous medium...
  18. Tian J, Ge B, Shen Y, He Y, Chen Z. Thermodynamics and Structural Evolution during a Reversible Vesicle-Micelle Transition of a Vitamin-Derived Bolaamphiphile Induced by Sodium Cholate. J Agric Food Chem. 2016;64:1977-88 pubmed publisher
    Interaction of endogenous sodium cholate (SC) with dietary amphiphiles would induce structural evolution of the self-assembled aggregates, which inevitably affects the hydrolysis of fat in the gut...
  19. Bottari E, Buonfigli A, Festa M. The influence of the ionic medium on the behaviour of sodium glycocholate and cholate aqueous solutions. Ann Chim. 2005;95:1-13 pubmed
    In the framework of research on the sodium bile salts, solutions of sodium cholate and glycocholate had been studied only at three ionic medium concentrations...
  20. Burón M, Hermán M, Alcain F, Villalba J. Stimulation of polyprenyl 4-hydroxybenzoate transferase activity by sodium cholate and 3-[(cholamidopropyl)dimethylammonio]-1-propanesulfonate. Anal Biochem. 2006;353:15-21 pubmed
    ..We have found that both 3-[(cholamidopropyl)dimethylammonio]-1-propanesulfonate and sodium cholate, but not sodium deoxycholate, lysophosphatidyl choline, or octylglucoside, significantly stimulate the ..
  21. Brambilla D, Souguir H, Nicolas J, Mackiewicz N, Verpillot R, Le Droumaguet B, et al. Colloidal properties of biodegradable nanoparticles influence interaction with amyloid-? peptide. J Biotechnol. 2011;156:338-40 pubmed publisher
    ..Whereas nanoparticles stabilized by sodium cholate (lower size and higher negative surface charge) gave optimum uptake kinetics, nanoparticles stabilized with ..
  22. Zubkova N, Anastasiev V, Kyuregyan K, Mikhailov M, Lobastova A, Krasil nikov I. Estimation of efficiency of solvent-detergent method for virus inactivation in the technology of immunoglobulin production on the model of duck hepatitis B virus. Bull Exp Biol Med. 2013;155:821-4 pubmed
    The virucidal action of solvent tributyl phosphate and detergent sodium cholate used in the production of immunoglobulin for inactivation of viruses with lipid envelope was studied on the model of duck hepatitis B virus...
  23. Choi J, Yu T, Cha B, Rhee M, Yoo E, Kim M, et al. Modulatory effects of ZYM-201 sodium succinate on dietary-induced hyperlipidemic conditions. Pharmazie. 2011;66:791-7 pubmed
  24. Reis S, Moutinho C, Matos C, de Castro B, Gameiro P, Lima J. Noninvasive methods to determine the critical micelle concentration of some bile acid salts. Anal Biochem. 2004;334:117-26 pubmed
    In this work the critical micelle concentrations (cmc) of four bile salts, sodium cholate, sodium glycocholate, sodium deoxycholate, and sodium glycodeoxycholate, are determined and presented...
  25. Guo B, Wen B, Shan X, Zhang S, Lin J. Separation and determination of phthalates by micellar electrokinetic chromatography. J Chromatogr A. 2005;1095:189-92 pubmed
    ..The baseline separation of phthalates was achieved by using a buffer of 100 mM sodium cholate, 50 mM borate and 15% methanol (pH 8.5)...
  26. Tran H, Tran P, Lee B. New findings on melatonin absorption and alterations by pharmaceutical excipients using the Ussing chamber technique with mounted rat gastrointestinal segments. Int J Pharm. 2009;378:9-16 pubmed publisher
    ..The possibility of saturating P-gp by melatonin was excluded. Sodium cholate (0.5%) increased melatonin absorption, but decreased absorption at higher concentrations (1.0% and 5.0%)...
  27. Wang S, Fan L, Cui S. CE-LIF chiral separation of aspartic acid and glutamic acid enantiomers using human serum albumin and sodium cholate as dual selectors. J Sep Sci. 2009;32:3184-90 pubmed publisher
    b>Sodium cholate (SC), beta-CD, hydroxypropyl (HP)-beta-CD, HSA, and the dual mixtures of them were evaluated for the analysis of aspartic acid (Asp) and glutamic acid (Glu) enantiomers fluorescently tagged with 5-(4,6-dichloro-s-triazin-2-..
  28. Holzer M, Barnert S, Momm J, Schubert R. Preparative size exclusion chromatography combined with detergent removal as a versatile tool to prepare unilamellar and spherical liposomes of highly uniform size distribution. J Chromatogr A. 2009;1216:5838-48 pubmed publisher
    ..The number-weighted average vesicle diameters obtained using both methods are in very good agreement for fractions of low polydispersity. ..
  29. Selvam S. A fluorescence parameter based analysis on the solubilization of carvedilol by bile salt media. J Photochem Photobiol B. 2012;116:105-13 pubmed publisher
    ..The results suggest that the CVL molecule associates with the steroidal moiety of bile salts through its carbazole moiety. ..
  30. Lin C, Chen Y. On-line identification of trans- and cis-resveratrol by nonaqueous capillary electrophoresis/fluorescence spectroscopy at 77 K. Electrophoresis. 2001;22:2574-9 pubmed
    ..The experimental results also indicate that the effect of nonaqueous capillary electrophoresis buffer and low-temperature technique increase the detection limit by more than 150-fold. ..
  31. Wu X, Li H, Song S, Zhang R, Hou W. Facile synthesis of camptothecin intercalated layered double hydroxide nanohybrids via a coassembly route. Int J Pharm. 2013;454:453-61 pubmed publisher
    ..this route, CPT molecules were initially incorporated into the micelles of a biocompatible surfactant, such as sodium cholate (SCh) or sodium deoxycholate (SDC)...
  32. Usrey M, Nair N, Agnew D, Pina C, Strano M. Controlling the electrophoretic mobility of single-walled carbon nanotubes: a comparison of theory and experiment. Langmuir. 2007;23:7768-76 pubmed
    ..The effects of functionalization with negatively charged 4-hydroxybenzene diazonium and anionic sodium cholate are quantified and compared with model predictions...
  33. Crego A, Gonzalez M, Marina M. Chiral separation of polychlorinated biphenyls by micellar electrokinetic chromatography with sodium cholate. Electrophoresis. 1998;19:2113-8 pubmed
    Micellar electrokinetic chromatography (MEKC) with one kind of bile salt (sodium cholate) was used to separate three chiral polychlorinated biphenyls (PCBs; 84, 95, and 176), each one in its two enantiomers...
  34. Ayotte N, Colin P. Spermicidal activity of a new contraceptive sponge. Adv Ther. 2002;19:219-28 pubmed
    ..The urgent need for female-controlled contraceptive methods with the potential to protect against sexually transmitted diseases makes this low-dose spermicidal vaginal sponge an effective and safe alternative. ..
  35. Mangiapia G, Paduano L, Ortona O, Sartorio R, D Errico G. Analysis of main- and cross-term diffusion coefficients in bile salt mixtures. J Phys Chem B. 2013;117:741-9 pubmed publisher
    Mutual diffusion coefficients have been measured for several average compositions of the system sodium cholate-sodium deoxycholate-water at 25 °C...
  36. Zhang S, Zhao Y. Effects of micelle properties on the conformation of oligocholates and importance of rigidity of foldamers. J Org Chem. 2012;77:556-62 pubmed publisher
    ..In Triton X-100 and sodium cholate solutions, the aggregated, unfolded, and folded oligocholates coexisted and gradual unfolding occurred with an ..
  37. Shang X, Yuan Z. Determination of hydroxyanthraquinoids in Rhubarb by cyclodextrin-modified micellar electrokinetic chromatography using a mixed micellar system of sodium dodecyl sulfate and sodium cholate. J Pharm Biomed Anal. 2003;31:75-81 pubmed using the mixed micellar system consisting of 20 mmol/l sodium dodecyl sulfate (SDS) and 20 mmol/l sodium cholate (SC) with 10 mmol/l beta-cyclodextrin in phosphate buffer (pH 10.4)...
  38. Tyner K, Schiffman S, Giannelis E. Nanobiohybrids as delivery vehicles for camptothecin. J Control Release. 2004;95:501-14 pubmed
    ..In addition, the modification of the surface of the LDH provided potential site-directing of the nanohybrids. These enhancements to the delivery scheme suggest the potential use of these hybrids for a variety of drug therapies...
  39. Lin S, Blankschtein D. Role of the bile salt surfactant sodium cholate in enhancing the aqueous dispersion stability of single-walled carbon nanotubes: a molecular dynamics simulation study. J Phys Chem B. 2010;114:15616-25 pubmed publisher
    ..dynamics (MD) simulation study of the adsorption and surface self-assembly of a common bile salt surfactant, sodium cholate (SC), on a SWNT in aqueous solution...
  40. Yu Q, Li P, Yang Q. Improving the absorption of earthworm fibrinolytic enzymes with mucosal enhancers. Pharm Biol. 2010;48:816-21 pubmed publisher
    ..These results obtained from in vitro experiments were similar to those in vivo. Moreover, menthol and glucose showed absorption enhancement properties with a relatively low cytotoxicity...
  41. Geusens B, Lambert J, De Smedt S, Buyens K, Sanders N, Van Gele M. Ultradeformable cationic liposomes for delivery of small interfering RNA (siRNA) into human primary melanocytes. J Control Release. 2009;133:214-20 pubmed publisher
    ..8:1 and 10:1) of the cationic lipid 1,2-dioleoyl-3-trimethylammonium propane (DOTAP) and the edge activator sodium cholate. Subsequently, UCL/siRNA complexes were prepared and their particle size, surface charge, deformability, ..
  42. Liu J, Gong T, Fu H, Wang C, Wang X, Chen Q, et al. Solid lipid nanoparticles for pulmonary delivery of insulin. Int J Pharm. 2008;356:333-44 pubmed publisher
    ..The influences of the amount of sodium cholate (SC) and soybean phosphatidylcholine (SPC) on the deposition properties of the nanoparticles were investigated...
  43. Celia C, Cilurzo F, Trapasso E, Cosco D, Fresta M, Paolino D. Ethosomes® and transfersomes® containing linoleic acid: physicochemical and technological features of topical drug delivery carriers for the potential treatment of melasma disorders. Biomed Microdevices. 2012;14:119-30 pubmed publisher
    ..and transfersomes® were prepared using Phospholipon 100 G®, as the lecithin component, and ethanol and sodium cholate, as edge activator agents, respectively. Linoleic acid at 0.05% and 0...
  44. Ikeda T. Effects of blockers of Ca2+ channels and other ion channels on in vitro excystment of Paragonimus ohirai metacercariae induced by sodium cholate. Parasitol Res. 2004;94:329-31 pubmed
    ..blockers were examined on in vitro excystment of Paragonimus ohirai metacercariae induced by a bile salt, sodium cholate. At a concentration of 10 microM, bepridil, a non-selective Ca(2+) channel blocker, completely inhibited in ..
  45. Neves L, Tsai T, Palwai N, Martyn D, Tan Y, Schmidtke D, et al. Non-covalent attachment of proteins to single-walled carbon nanotubes. Methods Mol Biol. 2010;625:3-8 pubmed publisher
    ..In this method, the protein is adsorbed to SWNTs that are suspended using sodium cholate, a surfactant and bile salt...
  46. Maswadeh H, Demetzos C, Dimas K, Hatziantoniou S, Georgopoulos A, Rallis M, et al. Accumulation of vinblastine into transfersomes and liposomes in response to a transmembrane ammonium sulfate gradient and their cytotoxic/cytostatic activity in vitro. Anticancer Res. 2001;21:2577-83 pubmed
    ..DMPC) and dipalmitoylphosphatidylcholine (DPPC), with cholesterol and transfersomes with sodium cholate prepared by the thin film hydration method...
  47. Pisani E, Fattal E, Paris J, Ringard C, Rosilio V, Tsapis N. Surfactant dependent morphology of polymeric capsules of perfluorooctyl bromide: influence of polymer adsorption at the dichloromethane-water interface. J Colloid Interface Sci. 2008;326:66-71 pubmed publisher
    ..While sodium cholate leads to spherical capsules of homogeneous thickness, sodium taurocholate induces to the formation of "..
  48. Deshmukh D, Ravis W, Betageri G. Improved delivery of cromolyn from oral proliposomal beads. Int J Pharm. 2008;358:128-36 pubmed publisher
    ..Phospholipid (distearylphosphatidylcholine)-cholesterol-surfactant (Tween 80/sodium cholate) systems were spray-coated on beads containing cromolyn sodium and the dosage forms were characterized for ..
  49. Kato Y, Niidome Y, Nakashima N. Spectroscopic analysis of two distinct equilibrium states for the exchange reaction of sodium cholate and oligo-DNA on single-walled carbon nanotubes. Chemphyschem. 2013;14:1652-5 pubmed publisher
    ..spectroscopy reveals that two different equilibrium states are existent for the exchange reaction of sodium cholate (SC) and oligo-DNA (single-stranded 20-mer cytosine) on SWNTs...
  50. Myasoedova K, Magretova N. Cross-Linking study of cytochrome P450 1A2 in proteoliposomes. Biosci Rep. 2001;21:63-72 pubmed
    ..Electrophoretic analysis of the modified proteins demonstrated the same oligomeric (hexameric) organization of the hemoprotein in each case. ..
  51. Puppato A, DuPré D, Stolowich N, Yappert M. Effect of temperature and pH on 31P nuclear magnetic resonances of phospholipids in cholate micelles. Chem Phys Lipids. 2007;150:176-85 pubmed
    ..aim was to establish the temperature coefficient (Deltadelta/DeltaT) of common phospholipid classes when using sodium cholate as detergent. This parameter can then be used to aid in resonance assignments...
  52. Wang Z, Zhang Q. [Study on pulmonary delivery of peptide drugs in rats: effects of absorption enhancers on cellular membrane fluidity]. Yao Xue Xue Bao. 2003;38:957-61 pubmed
    ..A series of model drug salmon calcitonin (sCT) solutions with 6 absorption enhancers (Brij78, sodium cholate, sodium caprylate, 2-hydroxypropyl-beta-cyclodextrin, lecithin and chitosan) were prepared and then delivered ..
  53. Tian K, Chen H, Tang J, Chen X, Hu Z. Enantioseparation of palonosetron hydrochloride by micellar electrokinetic chromatography with sodium cholate as chiral selector. J Chromatogr A. 2006;1132:333-6 pubmed
    ..of four stereoisomers of palonosetron hydrochloride by micellar electrokinetic chromatography using sodium cholate as chiral surfactant was described...