testosterone propionate


Summary: An ester of TESTOSTERONE with a propionate substitution at the 17-beta position.

Top Publications

  1. Hogg K, McNeilly A, Duncan W. Prenatal androgen exposure leads to alterations in gene and protein expression in the ovine fetal ovary. Endocrinology. 2011;152:2048-59 pubmed publisher
    ..Female fetuses were collected from ewes treated with 100 mg testosterone propionate (TP) or vehicle control (C), twice weekly from d 60 to 70 (C = 3, TP = 6) or d 90 (C = 6, TP = 8)...
  2. Wolf C, LeBlanc G, Gray L. Interactive effects of vinclozolin and testosterone propionate on pregnancy and sexual differentiation of the male and female SD rat. Toxicol Sci. 2004;78:135-43 pubmed
    ..In the current study, we administered V (gavage at 200 mg/kg/day) and/or testosterone propionate (TP, sc, at 1 mg/rat/day), alone and in combination to Sprague-Dawley (SD) rats on days 14 through 19 of ..
  3. Veiga Lopez A, Ye W, Phillips D, Herkimer C, Knight P, Padmanabhan V. Developmental programming: deficits in reproductive hormone dynamics and ovulatory outcomes in prenatal, testosterone-treated sheep. Biol Reprod. 2008;78:636-47 pubmed
  4. Abbott D, Bruns C, Barnett D, Dunaif A, Goodfriend T, Dumesic D, et al. Experimentally induced gestational androgen excess disrupts glucoregulation in rhesus monkey dams and their female offspring. Am J Physiol Endocrinol Metab. 2010;299:E741-51 pubmed publisher
    ..time-mated, gravid rhesus monkeys with female fetuses, of which nine gravid females received 15 mg of testosterone propionate (TP) subcutaneously daily from 40 to 80 days (first to second trimesters) of gestation [term, mean (range)..
  5. Hogg K, Young J, Oliver E, Souza C, McNeilly A, Duncan W. Enhanced thecal androgen production is prenatally programmed in an ovine model of polycystic ovary syndrome. Endocrinology. 2012;153:450-61 pubmed publisher
    ..Pregnant Scottish Greyface ewes were administered 100 mg testosterone propionate (TP) or vehicle control twice weekly from d 62 to 102 of gestation, and female offspring (TP = 9, control ..
  6. Jones S, Ismail N, King L, Pfaus J. The effects of chronic administration of testosterone propionate with or without estradiol on the sexual behavior and plasma steroid levels of aged female rats. Endocrinology. 2012;153:5928-39 pubmed publisher
    ..Here we examined the effect of chronic treatment with testosterone propionate (TP) administered by a sc SILASTIC brand capsule in aged ovary-intact female rats...
  7. Zhang G, Wang W, Kang Y, Xue Y, Yang H, Zhou C, et al. Chronic testosterone propionate supplement could activated the Nrf2-ARE pathway in the brain and ameliorated the behaviors of aged rats. Behav Brain Res. 2013;252:388-95 pubmed publisher
    ..TH-ir) cells in brain were examined in aged rats following chronic subcutaneous injections of testosterone propionate (TP)...
  8. Hogg K, Wood C, McNeilly A, Duncan W. The in utero programming effect of increased maternal androgens and a direct fetal intervention on liver and metabolic function in adult sheep. PLoS ONE. 2011;6:e24877 pubmed publisher
    ..Pregnant ewes received vehicle control (C; n?=?5) or testosterone propionate (TP; n?=?9) twice weekly (100 mg; i.m) from d62-102 (gestation 147 days)...
  9. Cui R, Zhang G, Kang Y, Cheng Q, Tan H, Cui H, et al. Amelioratory effects of testosterone propionate supplement on behavioral, biochemical and morphological parameters in aged rats. Exp Gerontol. 2012;47:67-76 pubmed publisher
    ..DAT) of NSDA system were examined in aged male rats following chronic subcutaneous injections of testosterone propionate (TP)...

More Information


  1. Veiga Lopez A, Steckler T, Abbott D, Welch K, MohanKumar P, Phillips D, et al. Developmental programming: impact of excess prenatal testosterone on intrauterine fetal endocrine milieu and growth in sheep. Biol Reprod. 2011;84:87-96 pubmed publisher
    ..Pregnant Suffolk sheep were administered either cottonseed oil (control) or testosterone propionate in cottonseed oil (100 mg, i.m. twice weekly), from Day 30 to Day 90 of gestation (term is ~147 d)...
  2. Ardia D, Broughton D, Gleicher M. Short-term exposure to testosterone propionate leads to rapid bill color and dominance changes in zebra finches. Horm Behav. 2010;58:526-32 pubmed publisher
    ..We tested whether a single injection of testosterone propionate (TP) would influence male-male dominance interactions and lead to rapid (over a three-day period) changes ..
  3. Zuloaga D, McGivern R, Handa R. Organizational influence of the postnatal testosterone surge on the circadian rhythm of core body temperature of adult male rats. Brain Res. 2009;1268:68-75 pubmed publisher
    ..Subsequently, we found that treating neonatally castrated males with testosterone propionate (TP) in adulthood did not reverse the effect of neonatal castration, thus indicating an organizational ..
  4. Abizaid A, Mezei G, Sotonyi P, Horvath T. Sex differences in adult suprachiasmatic nucleus neurons emerging late prenatally in rats. Eur J Neurosci. 2004;19:2488-96 pubmed
    ..These animals were also given injections of oil or testosterone propionate (10 mg/0.1 mL peanut oil) from E15 until parturition...
  5. Guo Q, Ding Q, Wu Z. Effect of baicalein on experimental prostatic hyperplasia in rats and mice. Biol Pharm Bull. 2004;27:333-7 pubmed
    ..Prostatic hyperplasia was induced by testosterone propionate in mice and castrated rats and by transplantation of homologous strain fetal mice urogenital sinus in ..
  6. Gouty Colomer L, Méry P, Storme E, Gavois E, Robinson I, Guerineau N, et al. Specific involvement of gonadal hormones in the functional maturation of growth hormone releasing hormone (GHRH) neurons. Endocrinology. 2010;151:5762-74 pubmed publisher
    ..Our results highlight the importance of the interaction between the somatotrope and gonadotrope axes during the establishment of adapted neuroendocrine functions. ..
  7. Tian J, Zheng Y, Yang C. [Effect of sex hormones on heme oxygenase expression in rat ventral prostate]. Sheng Li Xue Bao. 2004;56:54-9 pubmed
  8. Holmes M, Musa M, Lonstein J, Monks D. Sexual dimorphism and hormone responsiveness in the spinal cord of the socially monogamous prairie vole (Microtus ochrogaster). J Comp Neurol. 2009;516:117-24 pubmed publisher
    ..Unexpectedly, prenatal or early postnatal exposure to testosterone propionate had no effect on adult females' motoneuron number or size...
  9. de Olmos S, Bueno A, Bender C, Lorenzo A, de Olmos J. Sex differences and influence of gonadal hormones on MK801-induced neuronal degeneration in the granular retrosplenial cortex of the rat. Brain Struct Funct. 2008;213:229-38 pubmed publisher
    ..Thus, the balance of androgens and estrogens delineate the sexual dimorphism of the RSG to the toxic effect of MK801. ..
  10. Wang Q, Zhang A, Chen L. [Study on simultaneous determination method for banded synthesis hormones residues in egg products]. Wei Sheng Yan Jiu. 2009;38:740-6 pubmed
    ..used for testing Chlormadione acetate (CDA), Medroxypogesterone acetate (MPA), Megestrol Acetate (MA), Testosterone propionate (TSP), Norgestrel (NG), Methyltestosterone (MTS) and Nandrolone (NT) in egg products ranged from 0...
  11. Bormann C, Smith G, Padmanabhan V, Lee T. Prenatal testosterone and dihydrotestosterone exposure disrupts ovine testicular development. Reproduction. 2011;142:167-73 pubmed publisher
  12. Chatterjee R, Mukhopadhyay T, Chandra S, Bajoria R. Sex steroid priming for induction of puberty in thalassemia patients with pulsatile reversible hypogonadotrophic hypogonadism. Hemoglobin. 2011;35:659-64 pubmed publisher
    ..Our data suggest that sex steroid priming is a feasible method of induction of physiological puberty in ?-TM patients with sexual infantilism and reversible apulsatile HH, especially in younger patients with minimal iron loads. ..
  13. Mukai M, Dong Q, Hardy M, Kiyokawa H, Peterson R, Cooke P. Altered prostatic epithelial proliferation and apoptosis, prostatic development, and serum testosterone in mice lacking cyclin-dependent kinase inhibitors. Biol Reprod. 2005;73:951-8 pubmed
    ..Loss of p27 or of both p21 and p27 results in serum testosterone deficiency, complicating analysis of the prostatic effects of these cell-cycle regulators. ..
  14. Vinggaard A, Jacobsen H, Metzdorff S, Andersen H, Nellemann C. Antiandrogenic effects in short-term in vivo studies of the fungicide fenarimol. Toxicology. 2005;207:21-34 pubmed
    ..Thus, it is suggested that fenarimol mediates its antiandrogenic effects at least partly via antagonism of androgen receptors. ..
  15. Delev D, Davcheva D, Kostadinov I, Kostadinova I. Effect of testosterone propionate on erythropoiesis after experimental orchiectomy. Folia Med (Plovdiv). 2013;55:51-7 pubmed
    ..The aim of the experimental study was to determine the effect of substitution therapy with testosterone propionate (TP) on some haematological parameters of erythropoiesis in male rats after orchiectomy...
  16. McCormick D, Johnson W, Haryu T, Bosland M, Lubet R, Steele V. Null effect of dietary restriction on prostate carcinogenesis in the Wistar-Unilever rat. Nutr Cancer. 2007;57:194-200 pubmed
    ..induced in male Wistar-Unilever rats by a sequential regimen of cyproterone acetate (50 mg/day; 21 days); testosterone propionate (100 mg/kg/day; 3 days); N-methyl-N-nitrosourea [MNU; 30 mg/kg; single dose]; and testosterone (..
  17. Bisson J, Hidalgo S, Rozan P, Messaoudi M. Preventive effects of ACTICOA powder, a cocoa polyphenolic extract, on experimentally induced prostate hyperplasia in Wistar-Unilever rats. J Med Food. 2007;10:622-7 pubmed
    ..France) powder (AP), a cocoa polyphenolic extract, could prevent prostate hyperplasia induced by testosterone propionate (TP) in rats...
  18. Yoshimura Y, Fukui T, Nishibori M, Isobe N. Effects of age and gonadal steroids on the localization of antigen presenting cells in the epididymis of the male chicken, Gallus domesticus. J Reprod Dev. 2006;52:363-71 pubmed
    ..birds (immature 60-day-old birds; matured 150-, 330-, and 550-day-old), and immature birds treated with testosterone propionate (TP) or estradiol benzoate (EB) for 3 or 6 days were used...
  19. Almli L, Wilczynski W. Socially modulated cell proliferation is independent of gonadal steroid hormones in the brain of the adult green treefrog (Hyla cinerea). Brain Behav Evol. 2012;79:170-80 pubmed publisher
    ..These results show that the social modulation of cell proliferation can occur without gonadal hormone involvement in either male or female adult anuran amphibians, and confirms that it is independent of a behavioral response in males. ..
  20. Welsh M, Macleod D, Walker M, Smith L, Sharpe R. Critical androgen-sensitive periods of rat penis and clitoris development. Int J Androl. 2010;33:e144-52 pubmed publisher
    ..Thus, pregnant rats were treated with flutamide during the MPW +/- postnatal testosterone propionate (TP) treatment...
  21. Cunningham R, McGinnis M. Factors influencing aggression toward females by male rats exposed to anabolic androgenic steroids during puberty. Horm Behav. 2007;51:135-41 pubmed
    ..Gonadally intact males began one of three AAS treatments at puberty (D40): testosterone propionate (T), stanozolol (S), T+S, or vehicle control...
  22. Recabarren S, Rojas García P, Recabarren M, Alfaro V, Smith R, Padmanabhan V, et al. Prenatal testosterone excess reduces sperm count and motility. Endocrinology. 2008;149:6444-8 pubmed publisher
    ..Males born to mothers treated with 30 mg testosterone propionate twice weekly from d 30 to 90 and with 40 mg testosterone propionate from d 90 to 120 of pregnancy (T-..
  23. Hamson D, Wainwright S, Taylor J, Jones B, Watson N, Galea L. Androgens increase survival of adult-born neurons in the dentate gyrus by an androgen receptor-dependent mechanism in male rats. Endocrinology. 2013;154:3294-304 pubmed publisher
    ..Understanding where in the brain androgens act to increase the survival of new neurons in the adult brain may have implications for neurodegenerative disorders. ..
  24. Lund T, Munson D, Haldy M, Setchell K, Lephart E, Handa R. Equol is a novel anti-androgen that inhibits prostate growth and hormone feedback. Biol Reprod. 2004;70:1188-95 pubmed
  25. Lampit M, Hochberg Z. Androgen therapy in constitutional delay of growth. Horm Res. 2003;59:270-5 pubmed
    ..were randomly assigned into 3 treatment groups: group 1 patients received monthly injections of 25 mg testosterone propionate-enanthate; group 2 patients received monthly injections of 50 mg testosterone propionate-enanthate; group ..
  26. Miyagawa S, Matsumaru D, Murashima A, Omori A, Satoh Y, Haraguchi R, et al. The role of sonic hedgehog-Gli2 pathway in the masculinization of external genitalia. Endocrinology. 2011;152:2894-903 pubmed publisher
    ..The current study identified hedgehog signaling pathway as a key factor not only for initial development but also for sexually dimorphic development of the external genitalia in coordination with androgen signaling. ..
  27. Scott C, Mariani M, Clarke I, Tilbrook A. Effect of testosterone and season on proenkephalin messenger RNA expression in the preoptic area of the hypothalamus in the ram. Biol Reprod. 2003;69:2015-21 pubmed
    ..during the breeding season or nonbreeding season and received intramuscular injections of either oil or testosterone propionate (five/group). Blood samples were taken for the assay of plasma LH and testosterone...
  28. Chandra A, Ghosh R, Chatterjee A, Sarkar M. Protection against vanadium-induced testicular toxicity by testosterone propionate in rats. Toxicol Mech Methods. 2010;20:306-15 pubmed publisher
    ..The experiment also focused on the effects of testosterone propionate in testicular and sperm functions in the rat intoxicated with vanadate...
  29. Liu X, Li D, Zhang X, Wu J, Sun Z. Mitosis orientation in prostate epithelial cells changed by endocrine effect. Acta Pharmacol Sin. 2008;29:226-9 pubmed publisher
    ..Castrated rats were treated with a single injection of testosterone propionate (TP) or benzogynestry (E2). There were 8 rats in the control group and TP-treated or E2-treated group...
  30. Kawaguchi H, Miyoshi N, Miyamoto Y, Souda M, Umekita Y, Yasuda N, et al. Effects of fetal exposure to 4-n-octylphenol on mammary tumorigenesis in rats. In Vivo. 2010;24:463-70 pubmed
    ..These results suggest that fetal exposure to the very weak estrogenicity of OP could enhance the induction of MCs but not affect the induction of PLs. ..
  31. Sadowska Krepa E, Klapcinska B, Jagsz S, Chalimoniuk M, Chrapusta S, Wanke A, et al. Diverging oxidative damage and heat shock protein 72 responses to endurance training and chronic testosterone propionate treatment in three striated muscle types of adolescent male rats. J Physiol Pharmacol. 2013;64:639-47 pubmed
    ..The effects were studied of testosterone propionate (TP) treatment (8 and 80 mg/kg/week, for 6 weeks), given alone or in combination with moderate-intensity ..
  32. Guerra M, Silva R, Luchiari H, Sanabria M, Kempinas W. Perinatal androgenic exposure and reproductive health effects female rat offspring. J Toxicol Environ Health A. 2014;77:375-89 pubmed publisher
    ..Pregnant Wistar rats were exposed to testosterone propionate (TP) at doses of 0.05, 0.1, or 0...
  33. Bai R, Li P. [Influence of mild moxibustion on androgenic hormone in male rats with partial androgen deficiency]. Zhen Ci Yan Jiu. 2007;32:229-33, 236 pubmed
    ..Thirty male SD rats (aged 12 months) were randomized into control, androlin (testosterone propionate) and moxibustion ["Shenshu" (BL 23), "Mingmen" (GV 4) and 'Guanyuan" (CV 4)] ..
  34. Pinna G, Agis Balboa R, Pibiri F, Nelson M, Guidotti A, Costa E. Neurosteroid biosynthesis regulates sexually dimorphic fear and aggressive behavior in mice. Neurochem Res. 2008;33:1990-2007 pubmed publisher
  35. Müller D, Basso F, Kurrat A, Soukup S, Niehoff A, Kulling S, et al. Dose-dependent effects of isoflavone exposure during early lifetime on development and androgen sensitivity in male Wistar rats. Mol Nutr Food Res. 2016;60:325-36 pubmed publisher
    ..Most of the rats were orchiectomized at postnatal day (PND) 81 and were treated with testosterone propionate (TP) or vehicle from PND 89 to 99...
  36. Cunningham R, Claiborne B, McGinnis M. Pubertal exposure to anabolic androgenic steroids increases spine densities on neurons in the limbic system of male rats. Neuroscience. 2007;150:609-15 pubmed
    ..Pubertal gonadally intact male rats received the AAS testosterone propionate (5 mg/kg) or vehicle for 5 days/week for 4 weeks...
  37. Li J, Shen T, Wang Y, Wei Q, Shi F. Expression of matrix metalloproteinases and ovarian morphological changes in androgenized cyclic female guinea pigs. Tissue Cell. 2016;48:72-80 pubmed publisher
    ..Adult cyclic female guinea pigs were injected daily for 28 days with medium doses of testosterone propionate (TP; 1 mg/100g), high doses of TP (2 mg/100g), or saline (control)...
  38. Heimovics S, Riters L. Evidence that dopamine within motivation and song control brain regions regulates birdsong context-dependently. Physiol Behav. 2008;95:258-66 pubmed publisher
    ..Together, these data suggest DA in both song control and motivation brain regions may be more tightly linked to the regulation of highly goal-directed, sexually motivated vocal behavior...
  39. Arteaga Silva M, Rodríguez Dorantes M, Baig S, Morales Montor J. Effects of castration and hormone replacement on male sexual behavior and pattern of expression in the brain of sex-steroid receptors in BALB/c AnN mice. Comp Biochem Physiol A Mol Integr Physiol. 2007;147:607-15 pubmed
    ..course of decline of sexual behavior was studied, as well as the effects of daily treatment with either testosterone propionate (TP), estradiol benzoate (EB), or dihydrotestosterone propionate (PDHT)...
  40. Zhou Q, Shima J, Nie R, Friel P, Griswold M. Androgen-regulated transcripts in the neonatal mouse testis as determined through microarray analysis. Biol Reprod. 2005;72:1010-9 pubmed
    ..In the present study, neonatal male mice (8 days postpartum) treated by testosterone propionate (TP) were used to study androgen action in the testis as evidenced by alterations in gene expression...
  41. Jia J, Wu Y, Zhou X, Wang Y. Effects of testosterone propionate on oxidative stress and the expression of spleen cytokine genes in endosulfan-treated mice. J Environ Pathol Toxicol Oncol. 2012;31:17-26 pubmed
    The purpose of this research was to investigate the effects of testosterone propionate on oxidative stress and cytokine gene expression in endosulfan-treated mice...
  42. Wu G, Lin Y, Ou M, Tan D. [An experimental study(II) on the inhibition of prostatic hyperplasia by extract of seeds of Brassica alba]. Zhongguo Zhong Yao Za Zhi. 2003;28:643-6 pubmed
    ..Prostatic hyperplasia of castrated male mice induced by testosterone propionate, the penetrability of capillary vessel of mice skin induced by histamine and the endermic flesh bud of ..
  43. Garcia Esperon C, Hervás García J, Jiménez González M, Pérez de la Ossa Herrero N, Gomis Cortina M, Dorado Bouix L, et al. [Ingestion of anabolic steroids and ischaemic stroke. A clinical case report and review of the literature]. Rev Neurol. 2013;56:327-31 pubmed
    ..CONCLUSIONS. The association between consumption of anabolic-androgenic steroids and cardiovascular pathologies is known, but its relation with cerebrovascular disease has not received so much attention from researchers. ..
  44. Fitts J, Klein R, Powers C. Comparison of tamoxifen and testosterone propionate in male rats: differential prevention of orchidectomy effects on sex organs, bone mass, growth, and the growth hormone-IGF-I axis. J Androl. 2004;25:523-34 pubmed
    ..As a preclinical test of this idea, tamoxifen (a SERM) and testosterone propionate (TP, a classic androgen) were compared for their efficacy in preventing varied effects of orchidectomy (..
  45. Jeon W, Kim O, Seo C, Jin S, Kim J, Shin H, et al. Inhibitory effects of Ponciri Fructus on testosterone-induced benign prostatic hyperplasia in rats. BMC Complement Altern Med. 2017;17:384 pubmed publisher
    ..of a Ponciri Fructus extract (PFE) on the development of BPH in a in a rat model of BPH induced by testosterone propionate (TP)...
  46. Yamada T, Kunimatsu T, Miyata K, Yabushita S, Sukata T, Kawamura S, et al. Enhanced rat Hershberger assay appears reliable for detection of not only (anti-)androgenic chemicals but also thyroid hormone modulators. Toxicol Sci. 2004;79:64-74 pubmed
    ..Castrated or testosterone propionate (TP; 0.2 or 0...
  47. Cushing B, Razzoli M, Murphy A, Epperson P, Le W, Hoffman G. Intraspecific variation in estrogen receptor alpha and the expression of male sociosexual behavior in two populations of prairie voles. Brain Res. 2004;1016:247-54 pubmed
  48. Salvetti N, Ortega H, Veiga Lopez A, Padmanabhan V. Developmental programming: impact of prenatal testosterone excess on ovarian cell proliferation and apoptotic factors in sheep. Biol Reprod. 2012;87:22, 1-10 pubmed publisher
    ..Overall, the findings demonstrate that fetal exposure to excess T disrupts the ovarian proliferation/apoptosis balance, thus providing a basis for the follicular disruptions evidenced in these females. ..
  49. Aydilek N, Aksakal M, Karakilcik A. Effects of testosterone and vitamin E on the antioxidant system in rabbit testis. Andrologia. 2004;36:277-81 pubmed
    The aim of the study was to investigate the effects of testosterone propionate and vitamin E on the antioxidant system in the testis. Thirty-two male New Zealand White rabbits were randomly divided into four groups...
  50. Ayhan A, Guven E, Guven S, Sakinci M, Dogan N, Kucukali T. Testosterone versus clobetasol for maintenance of vulvar lichen sclerosus associated with variable degrees of squamous cell hyperplasia. Acta Obstet Gynecol Scand. 2007;86:715-9 pubmed
    ..All patients were initially treated with topical fluorinated corticosteroids, and then 2% testosterone propionate in petrolatum or 0.05% clobetasol 17-propionate (44 (53%) versus 39 (47%))...
  51. Frese S, Velders M, Schleipen B, Schanzer W, Bloch W, Diel P. Myosin heavy chain expression pattern as a marker for anabolic potency: desoxymethyltestosterone (madol), norandrostenedione and testosterone repress MHC-IIb expression and stimulate MHC-IId/x expression in orchiectomized rat gastrocnemius muscle. Arch Toxicol. 2011;85:635-43 pubmed publisher
    ..The aim of this study was to investigate the anabolic potency of NOR, madol and the reference substance testosterone propionate (TP). Besides wet weight of the M...
  52. Nishi N, Shoji H, Miyanaka H, Nakamura T. Transient up-regulation of a novel member of Spot 14 family in androgen-stimulated rat prostate. Biochim Biophys Acta. 2008;1780:1004-9 pubmed publisher
    ..Though the physiological role of SLAP remains to be clarified, the current results suggest that SLAP expression is associated with some growth-related processes in regrowing rat prostate. ..
  53. Fischer L, Arthuri M, Torres Chávez K, Tambeli C. Contribution of endogenous opioids to gonadal hormones-induced temporomandibular joint antinociception. Behav Neurosci. 2009;123:1129-40 pubmed publisher
    ..This suggestion helps explain the higher severity of some pain conditions, such as temporomandibular dysfunctions in women than in men, that have no hormonal fluctuations. ..