methyltestosterone

Summary

Summary: A synthetic hormone used for androgen replacement therapy and as an hormonal antineoplastic agent (ANTINEOPLASTIC AGENTS, HORMONAL).

Top Publications

  1. Papaconstantinou A, Umbreit T, Goering P, Brown K. Effects of 17 alpha-methyltestosterone on uterine morphology and heat shock protein expression are mediated through estrogen and androgen receptors. J Steroid Biochem Mol Biol. 2002;82:305-14 pubmed
    Testosterone and the synthetic androgen, 17 alpha-methyltestosterone (MT), have been shown to increase uterine weights and alter uterine morphology...
  2. Riley L, Richman N, Hirano T, Gordon Grau E. Activation of the growth hormone/insulin-like growth factor axis by treatment with 17 alpha-methyltestosterone and seawater rearing in the tilapia, Oreochromis mossambicus. Gen Comp Endocrinol. 2002;127:285-92 pubmed
    Effects of 17 alpha-methyltestosterone (MT) treatment and environmental salinity on the growth hormone (GH)/insulin-like growth factor (IGF) axis were examined in the euryhaline tilapia, Oreochromis mossambicus...
  3. Dias R, Kerr Correa F, Moreno R, Trinca L, Pontes A, Halbe H, et al. Efficacy of hormone therapy with and without methyltestosterone augmentation of venlafaxine in the treatment of postmenopausal depression: a double-blind controlled pilot study. Menopause. 2006;13:202-11 pubmed
    ..625 mg) in combination with medroxyprogesterone acetate (2.5 mg) and methyltestosterone (2.5 mg). Seventy-two menopausal women (mean age: 53.6 +/- 4...
  4. Shin J, Moon H, Kang I, Kim T, Lee S, Ahn J, et al. OECD validation of the rodent Hershberger assay using three reference chemicals; 17alpha-methyltestosterone, procymidone, and p,p'-DDE. Arch Toxicol. 2007;81:309-18 pubmed
    ..As part of the international validation work, we studied 17alpha-methyltestosterone for evaluating androgenic activity, and procymidone and p,p'-DDE for evaluating antiandrogenic activity...
  5. Zhang W, Zhang Y, Zhang L, Zhao H, Li X, Huang H, et al. The mRNA expression of P450 aromatase, gonadotropin beta-subunits and FTZ-F1 in the orange-spotted grouper (Epinephelus Coioides) during 17alpha-methyltestosterone-induced precocious sex change. Mol Reprod Dev. 2007;74:665-73 pubmed
    ..2-year-old orange-spotted grouper was induced to change sex precociously by oral administration of 17alpha-methyltestosterone (MT, 50 mg/Kg diet, twice a day at daily ration of 5% bodyweight) for 60 days...
  6. Kitano T, Takamune K, Nagahama Y, Abe S. Aromatase inhibitor and 17alpha-methyltestosterone cause sex-reversal from genetical females to phenotypic males and suppression of P450 aromatase gene expression in Japanese flounder (Paralichthys olivaceus). Mol Reprod Dev. 2000;56:1-5 pubmed
    ..study, we show that treatment of genetically female larvae with fadrozole (aromatase inhibitor) or 17alpha-methyltestosterone induces sex-reversal as well as suppression of P450arom gene expression...
  7. Ashby J, Owens W, Lefevre P. Concept evaluation: androgen-stimulated immature intact male rats as an assay for antiandrogens. Regul Toxicol Pharmacol. 2002;35:280-5 pubmed
    The effects of the concomitant oral administration of a potent reference androgen (17alpha-methyltestosterone) and both a potent (flutamide) and a weak (p,p'-DDE) antiandrogen on intact weanling male rats are described...
  8. Andersen L, Goto Kazeto R, Trant J, Nash J, Korsgaard B, Bjerregaard P. Short-term exposure to low concentrations of the synthetic androgen methyltestosterone affects vitellogenin and steroid levels in adult male zebrafish (Danio rerio). Aquat Toxicol. 2006;76:343-52 pubmed
    Short-term effects of methyltestosterone (MT) on the endocrine system of adult male zebrafish (Danio rerio) were examined. Males were exposed to 0, 4.5, 6.6, 8.5, 19.8, 35.9, 62.3 ng MT/l and ethinylestradiol (EE2) (26.4 ng/l) for 7 days...
  9. Raghuveer K, Senthilkumaran B. Identification of multiple dmrt1s in catfish: localization, dimorphic expression pattern, changes during testicular cycle and after methyltestosterone treatment. J Mol Endocrinol. 2009;42:437-48 pubmed publisher
    ..Analysis of dmrt1, sox9a, foxl2 and cyp19a1 expression patterns in MT-treated gonads revealed tissue-specific pattern. These results together suggest that multiple dmrt1s are testis-specific markers in catfish...

More Information

Publications61

  1. Lobo R, Rosen R, Yang H, Block B, van der Hoop R. Comparative effects of oral esterified estrogens with and without methyltestosterone on endocrine profiles and dimensions of sexual function in postmenopausal women with hypoactive sexual desire. Fertil Steril. 2003;79:1341-52 pubmed
    ..We sought to characterize the hormonal effects of the combination of oral esterified estrogens and methyltestosterone and to investigate whether this regimen improves hypoactive sexual desire. Double-blind randomized trial...
  2. Barreto Estrada J, Barreto J, Fortis Santiago Y, Rivera Ramos I, Fortis Santiago A, Jorge J. Modulation of affect after chronic exposure to the anabolic steroid 17alpha-methyltestosterone in adult mice. Behav Neurosci. 2004;118:1071-9 pubmed
    ..in affective components of behavior after systemic exposure to the anabolic-androgenic steroid (AAS) 17alpha-methyltestosterone (7.5 mg/kg). Gonadal weight in both sexes was reduced after 16 days of AAS exposure...
  3. Penteado S, Fonseca A, Bagnoli V, Abdo C, Júnior J, Baracat E. Effects of the addition of methyltestosterone to combined hormone therapy with estrogens and progestogens on sexual energy and on orgasm in postmenopausal women. Climacteric. 2008;11:17-25 pubmed publisher
    To evaluate the effect of the addition of methyltestosterone to estrogen and progestogen therapy on postmenopausal sexual energy and orgasm...
  4. Rivera Arce J, Morales Crespo L, Vargas Pinto N, Velazquez K, Jorge J. Central effects of the anabolic steroid 17alpha methyltestosterone in female anxiety. Pharmacol Biochem Behav. 2006;84:275-81 pubmed
    The androgen 17alpha-methyltestosterone (17alpha-meT) is one of the most commonly abused anabolic androgenic steroids (AAS)...
  5. LeGros T, McConnell D, Murry T, Edavettal M, Racey Burns L, Shepherd R, et al. The effects of 17 alpha-methyltestosterone on myocardial function in vitro. Med Sci Sports Exerc. 2000;32:897-903 pubmed
  6. Pozo O, Van Eenoo P, Deventer K, Lootens L, Van Thuyne W, Parr M, et al. Detection and characterization of a new metabolite of 17alpha-methyltestosterone. Drug Metab Dispos. 2009;37:2153-62 pubmed publisher
    The misuse of the anabolic steroid methyltestosterone is currently routinely monitored in doping control laboratories by gas chromatography-mass spectrometry (GC-MS) of two of its metabolites: 17alpha-methyl-5beta-androstane-3alpha,17beta-..
  7. Khurana R, Labree L, Scott G, Smith R, Yiu S. Esterified estrogens combined with methyltestosterone raise intraocular pressure in postmenopausal women. Am J Ophthalmol. 2006;142:494-5 pubmed
    To investigate the effect of esterified estrogens combined with methyltestosterone (EECM) (Estratest, Solvay, Pharmaceuticals, Inc, Baudette, Minnesota, USA) on intraocular pressure (IOP) in postmenopausal women. Observational case series...
  8. Kanamori A, Yamamura A, Koshiba S, Lee J, Orlando E, Hori H. Methyltestosterone efficiently induces male development in the self-fertilizing hermaphrodite fish, Kryptolebias marmoratus. Genesis. 2006;44:495-503 pubmed publisher
    ..Here we report that 17alpha-methyltestosterone (MT) treatment of the embryos converted most of the fish to males...
  9. Hornung M, Jensen K, Korte J, Kahl M, Durhan E, Denny J, et al. Mechanistic basis for estrogenic effects in fathead minnow (Pimephales promelas) following exposure to the androgen 17alpha-methyltestosterone: conversion of 17alpha-methyltestosterone to 17alpha-methylestradiol. Aquat Toxicol. 2004;66:15-23 pubmed
    Exposure of adult fathead minnows (Pimephales promelas) to the androgen 17alpha-methyltestosterone (MT) produces both androgenic and estrogenic effects, manifested as nuptial tubercle formation in females, and vitellogenin production in ..
  10. Yamasaki K, Sawaki M, Ohta R, Okuda H, Katayama S, Yamada T, et al. OECD validation of the Hershberger assay in Japan: phase 2 dose response of methyltestosterone, vinclozolin, and p,p'-DDE. Environ Health Perspect. 2003;111:1912-9 pubmed
    ..Seven Japanese laboratories have contributed phase 2 validation studies of the Hershberger assay using methyltestosterone, vinclozolin, and 2,2-bis (4-chlorophenyl)-1,1-dichloroethylene (p,p'-DDE)...
  11. Orn S, Holbech H, Madsen T, Norrgren L, Petersen G. Gonad development and vitellogenin production in zebrafish (Danio rerio) exposed to ethinylestradiol and methyltestosterone. Aquat Toxicol. 2003;65:397-411 pubmed
    In a partial life-cycle test, the impact of 17alpha-ethinylestradiol (EE2) and 17alpha-methyltestosterone (MT) on juvenile zebrafish was evaluated by use of vitellogenin measurements and gonadal development...
  12. Wisniewski A, Nguyen T, Dobs A. Evaluation of high-dose estrogen and high-dose estrogen plus methyltestosterone treatment on cognitive task performance in postmenopausal women. Horm Res. 2002;58:150-5 pubmed
    To investigate the cognitive effects of high-dose oral estrogen alone or in combination with oral methyltestosterone in postmenopausal women...
  13. Kang I, Yokota H, Oshima Y, Tsuruda Y, Shimasaki Y, Honjo T. The effects of methyltestosterone on the sexual development and reproduction of adult medaka (Oryzias latipes). Aquat Toxicol. 2008;87:37-46 pubmed publisher
    We examined the effects of methyltestosterone (MT) on the reproduction of medaka (Oryzias latipes). Six mating pairs of medaka were exposed for 3 weeks to MT at the measured concentrations of 22.5, 46.8, 88.1, 188, and 380 ng/L...
  14. Daly R, Su T, Schmidt P, Pickar D, Murphy D, Rubinow D. Cerebrospinal fluid and behavioral changes after methyltestosterone administration: preliminary findings. Arch Gen Psychiatry. 2001;58:172-7 pubmed
    ..and neuropeptides in the cerebrospinal fluid (CSF) of 17 healthy men, at baseline and following 6 days of methyltestosterone (MT) administration (3 days of 40 mg/d, then 3 days of 240 mg/d)...
  15. Leão L, Duarte M, Silva D, Bahia P, Coeli C, de Farias M. Influence of methyltestosterone postmenopausal therapy on plasma lipids, inflammatory factors, glucose metabolism and visceral fat: a randomized study. Eur J Endocrinol. 2006;154:131-9 pubmed
    ..double-blind protocol to receive, for 12 months, percutaneous estradiol (E2) (1 mg/day) combined with either methyltestosterone (MT) (1.25 mg/day) or placebo...
  16. Ankley G, Jensen K, Kahl M, Korte J, Makynen E. Description and evaluation of a short-term reproduction test with the fathead minnow (Pimephales promelas). Environ Toxicol Chem. 2001;20:1276-90 pubmed
    ..and evaluate the test using two model reproductive toxicants, methoxychlor (an estrogenic compound) and methyltestosterone (an androgenic chemical)...
  17. Cui G, Xu Z, Yang Z, Xu Y, Xue S. A combined regimen of gossypol plus methyltestosterone and ethinylestradiol as a contraceptive induces germ cell apoptosis and expression of its related genes in rats. Contraception. 2004;70:335-42 pubmed
    ..we formulated a regimen of combined gossypol at a low dose of 12 mg/kg or a high dose of 50 mg/kg plus methyltestosterone 20 mg/kg and ethinylestradiol 100 g/kg daily (12 mg G+H and 50 mg G+H) administered for 6 weeks in adult ..
  18. Chiuve S, Martin L, Campos H, Sacks F. Effect of the combination of methyltestosterone and esterified estrogens compared with esterified estrogens alone on apolipoprotein CIII and other apolipoproteins in very low density, low density, and high density lipoproteins in surgically postmenop. J Clin Endocrinol Metab. 2004;89:2207-13 pubmed
    ..The objective of this study was to assess the effect of oral methyltestosterone (2.5 mg/d), added to esterified estrogens (1...
  19. Han Y, Ma Q, Lu J, Xue Y, Xue C. Optimisation for subcritical fluid extraction of 17-methyltestosterone with 1,1,1,2-tetrafluoroethane for HPLC analysis. Food Chem. 2012;135:2988-93 pubmed publisher
    A simple, rapid and sensitive method was developed for determination of 17?-methyltestosterone in aquatic products by extraction with subcritical 1,1,1,2-tetrafluoroethane (R134a) extraction and high performance liquid chromatography (..
  20. Blasberg M, Clark A. Anabolic-androgenic steroid effects on sexual receptivity in ovariectomized rats. Horm Behav. 1997;32:201-8 pubmed
    ..c. injections of 7.5 mg/kg of one of the following AAS compounds: 17 alpha-methyltestosterone, methandrostenolone, nandrolone decanoate, stanozolol, oxymetholone, testosterone cypionate, or the oil ..
  21. Shi Y, Yao J, Liu F, Hu C, Yuan J, Zhang Q, et al. Establishment of an HPLC identification system for detection of counterfeit steroidal drugs. J Pharm Biomed Anal. 2008;46:663-9 pubmed publisher
    ..analysis of nine steroidal drugs, ethinylestradiol, diethylstilbestrol, norethisterone, norgestrel, methyltestosterone, medroxyprogesterone acetate, progesterone, testosterone propionate and nilestriol...
  22. Suthers K. Estratest is not approved by the Food and Drug Administration. Arch Intern Med. 2007;167:205-6 pubmed
  23. Ness R, Albano J, McTiernan A, Cauley J. Influence of estrogen plus testosterone supplementation on breast cancer. Arch Intern Med. 2009;169:41-6 pubmed publisher
    ..the relationship between the use of estrogen plus testosterone (E + T) therapy (esterified estradiol plus methyltestosterone) and the occurrence of breast cancer...
  24. Friebely J, Shifren J, Schiff I, Regestein Q. Preliminary observations on differing psychological effects of conjugated and esterified estrogen treatments. J Womens Health Gend Based Med. 2001;10:181-7 pubmed
    ..a double-blind comparison of menopausal replacement therapy with estrogen alone compared with estrogen plus methyltestosterone (meT), subjects who had been on conjugated equine estrogen (CEE) said they felt better when placed on ..
  25. Kokkonen J, Leinonen A, Tuominen J, Seppala T. Comparison of sensitivity between gas chromatography-low-resolution mass spectrometry and gas chromatography-high-resolution mass spectrometry for determining metandienone metabolites in urine. J Chromatogr B Biomed Sci Appl. 1999;734:179-89 pubmed
    ..The results suggest that metandienone misuse can be detected by HRMS for a prolonged period after stopping the intake of metandienone. ..
  26. Park C, Soyano K, Kiros S, Kitamura T, Minamiyama M, Suzuki Y. Transient effects of methyltestosterone injection on different reproductive parameters of the hermaphrodite fish Kryptolebias marmoratus. Ecotoxicology. 2013;22:1145-54 pubmed publisher
    ..individuals of the hermaphrodite fish Kryptolebias marmoratus were injected once with six concentrations of methyltestosterone (MT) (0.1, 1, 5, 10, 50, and 100 ?g/g BW) intraperitoneally...
  27. Singh A. Introduction of modern endocrine techniques for the production of monosex population of fishes. Gen Comp Endocrinol. 2013;181:146-55 pubmed publisher
    ..This paper presents the synthesis of works done on sex reversal using 17? methyltestosterone (17?MT), 17? estradiol, non-steroidal aromatase inhibitors (AIs) and oestrogen receptor agonist, tamoxifen ..
  28. Qi X, Zhang L, Zhang X. Simultaneous determination of nandrolone, testosterone, and methyltestosterone by multi-immunoaffinity column and capillary electrophoresis. Electrophoresis. 2008;29:3398-405 pubmed publisher
    ..immunoaffinity column was proposed for the purification and enrichment of nandrolone, testosterone, and methyltestosterone from urine...
  29. Luckenbach J, Fairgrieve W. Gonadal sex differentiation and effects of dietary methyltestosterone treatment in sablefish (Anoplopoma fimbria). Fish Physiol Biochem. 2016;42:233-48 pubmed publisher
    ..Juveniles with undifferentiated gonads were provided diets containing 0 (control), 5 or 50 mg 17α-methyltestosterone (MT)/kg for 2 months...
  30. Kennel P, Pallen C, Bars R. Evaluation of the rodent Hershberger assay using three reference endocrine disrupters (androgen and antiandrogens). Reprod Toxicol. 2004;18:63-73 pubmed
    ..studied included the antiandrogens finasteride (FIN) and procymidone (PRO) and the androgen agonist 17alpha-methyltestosterone (MT)...
  31. Notelovitz M. Hot flashes and androgens: a biological rationale for clinical practice. Mayo Clin Proc. 2004;79:S8-13 pubmed
    ..The pharmacodynamic differences of testosterone and methyltestosterone are briefly reviewed in the context of choice for individualized clinical use.
  32. Bartmańska A, Dmochowska Gładysz J, Huszcza E. Steroids' transformations in Penicillium notatum culture. Steroids. 2005;70:193-8 pubmed
    ..Microbial production of testolactones, the biologically active compounds, was also achieved using this strain in up to 98% yield. ..
  33. McKinney A, Suann C, Stenhouse A. A stereochemical examination of the equine metabolism of 17alpha-methyltestosterone. Anal Chim Acta. 2007;581:377-87 pubmed
    An investigation was conducted into the stereochemistry of the equine urinary metabolites of 17alpha-methyltestosterone observed after oral administration...
  34. Homklin S, Ong S, Limpiyakorn T. Degradation of 17?-methyltestosterone by Rhodococcus sp. and Nocardioides sp. isolated from a masculinizing pond of Nile tilapia fry. J Hazard Mater. 2012;221-222:35-44 pubmed publisher
    17?-Methyltestosterone (MT), a synthetic anabolic androgenic steroid, is widely used in aquafarming for the production of an all male fish population such as Nile tilapia...
  35. Hemmer M, Salinas K, Harris P. Application of protein expression profiling to screen chemicals for androgenic activity. Aquat Toxicol. 2011;103:71-8 pubmed publisher
    ..0?g/L: dihydrotestosterone (DHT), methyldihydrotestosterone (MDHT), testosterone (T), methyltestosterone (MT) and trenbolone (TB). Treatments of 0...
  36. Oberlander J, Porter D, Onakomaiya M, Penatti C, Vithlani M, Moss S, et al. Estrous cycle variations in GABA(A) receptor phosphorylation enable rapid modulation by anabolic androgenic steroids in the medial preoptic area. Neuroscience. 2012;226:397-410 pubmed publisher
    ..Acute exposure to the AAS, 17?-methyltestosterone (17?-MeT), had no effect on the amplitude or kinetics of inhibitory postsynaptic currents in the mPOA of ..
  37. Zhang X, Li J, Gao J, Sun L, Chang W. Determination of doping methyltestosterone by capillary electrophoresis immunological analysis with thermally reversible hydrogel and laser-induced fluorescence. Electrophoresis. 1999;20:1998-2002 pubmed
    ..A simple and rapid method of detecting doping methyltestosterone (MTS) was developed, which demonstrated the potential of strong affinity antibodies (k(d) = 10(9)) as a ..
  38. Scott G, Yiu S, Wasilewski D, Song J, Smith R. Combined esterified estrogen and methyltestosterone treatment for dry eye syndrome in postmenopausal women. Am J Ophthalmol. 2005;139:1109-10 pubmed
    To determine whether systemic replacement with combined esterified estrogen (EE) and methyltestosterone (MT) (EE + MT) would reduce symptoms and promote clinical improvement in postmenopausal women with dry eye syndrome (DES)...
  39. Vogt G. Exposure of the eggs to 17alpha-methyl testosterone reduced hatching success and growth and elicited teratogenic effects in postembryonic life stages of crayfish. Aquat Toxicol. 2007;85:291-6 pubmed
    ..The marbled crayfish is recommended to be considered for toxicity tests due to its easy culture in the laboratory and its genotypical uniformity. ..
  40. Ren Y, Sun L, Jiang W, Hu C. [Effects of glycosides of Tripterygium wilfordii, methyltestosterone and zhuanggushenjin capsule on nitric oxide synthase in rat testes]. Zhonghua Nan Ke Xue. 2005;11:343-5, 349 pubmed
    To investigate the effects of glycosides of tripterygium wilfordii (GTW), methyltestosterone and Zhuanggushenjin capsule on nitric oxide synthase (NOS) in rat testes...
  41. Ogino Y, Hirakawa I, Inohaya K, Sumiya E, Miyagawa S, Denslow N, et al. Bmp7 and Lef1 are the downstream effectors of androgen signaling in androgen-induced sex characteristics development in medaka. Endocrinology. 2014;155:449-62 pubmed publisher
    ..processes concomitant with the induction of Bmp7 and Lef1 in the distal bone nodules by exposure to methyltestosterone was significantly suppressed by an antiandrogen, flutamide, in female medaka...
  42. Stange D, Sieratowicz A, Horres R, Oehlmann J. Freshwater mudsnail (Potamopyrgus antipodarum) estrogen receptor: identification and expression analysis under exposure to (xeno-)hormones. Ecotoxicol Environ Saf. 2012;75:94-101 pubmed publisher
    ..is differentially expressed under exposure to (xeno-)hormones (17?-ethinylestradiol, bisphenol A and 17?-methyltestosterone)...
  43. Phumyu N, Boonanuntanasarn S, Jangprai A, Yoshizaki G, Na Nakorn U. Pubertal effects of 17?-methyltestosterone on GH-IGF-related genes of the hypothalamic-pituitary-liver-gonadal axis and other biological parameters in male, female and sex-reversed Nile tilapia. Gen Comp Endocrinol. 2012;177:278-92 pubmed publisher
    The influence of 17?-methyltestosterone (MT) on growth responses, biological parameters and the expression of genes involved in the GH-IGF pathway of the hypothalamic-pituitary-liver-gonadal axis were investigated in female, male, and sex-..
  44. Smith S, Stackman R, Clark A. Spatial working memory is preserved in rats treated with anabolic-androgenic steroids. Brain Res. 1996;737:313-6 pubmed
    ..Thirty days of administration of a high dose of three individual AAS compounds (17 alpha-methyltestosterone, methandrostenolone, or testosterone cypionate) had no effects on spatial memory or motivation as tested on ..
  45. Friedl K, Hannan C, Jones R, Plymate S. High-density lipoprotein cholesterol is not decreased if an aromatizable androgen is administered. Metabolism. 1990;39:69-74 pubmed
    ..mg/wk intramuscularly [IM]); TE (280 mg/wk IM) + testolactone (TL) (250 mg orally [PO] four times daily); or methyltestosterone (MeT) (20 mg PO twice daily)...
  46. Kirkbride Smith A, Bell H, Edwards J. Effects of three vertebrate hormones on the growth, development, and reproduction of the tomato moth, Lacanobia oleracea L. (Lepidoptera: Noctuidae). Environ Toxicol Chem. 2001;20:1838-45 pubmed
    ..05) decrease in egg viability. The physiological effects observed in L. oleracea and their possible causes are presented in this paper, and the likely impact of EDS and their effects on terrestrial invertebrates are discussed. ..
  47. Amarasinghe K, Chu P, EVANS E, Reimschuessel R, Hasbrouck N, Jayasuriya H. Development of a fast screening and confirmatory method by liquid chromatography-quadrupole-time-of-flight mass spectrometry for glucuronide-conjugated methyltestosterone metabolite in tilapia. J Agric Food Chem. 2012;60:5084-8 pubmed publisher
    This paper describes the development of a fast method to screen and confirm methyltestosterone 17-O-glucuronide (MT-glu) in tilapia bile...
  48. Yang M, Gu W, Sun L, Zhang F, Ling Y, Chu X, et al. Study on the molecularly imprinted polymers with methyl-testosterone as the template. Talanta. 2010;81:156-61 pubmed publisher
    ..At the same time, the MIPs could be used as SPE column to enrich methyl-testosterone in the lake water and show broad prospects in real samples. ..
  49. Zhao S, Wu D, Wang P. [Simultaneous determination of seven sexual hormones in cosmetics by reversed-phase high performance liquid chromatography]. Se Pu. 2004;22:267-9 pubmed
    ..9999, and the limits of detection were from 3.7 to 12 ng. The method is suitable to simultaneously assay the seven sexual hormones in cosmetics with simplicity and accuracy in a single injection. ..
  50. Bhandari R, Nakamura M, Kobayashi T, Nagahama Y. Suppression of steroidogenic enzyme expression during androgen-induced sex reversal in Nile tilapia (Oreochromis niloticus). Gen Comp Endocrinol. 2006;145:20-4 pubmed
    ..of androgen-induced testicular differentiation, we treated female tilapia Oreochromis niloticus with methyltestosterone (MT at a dose of 50 microg/g diet) and examined the expression of P450 cholesterol-side-chain-cleavage, ..
  51. Selzsam B, Grote K, Gericke C, Niemann L, Wittfoht W, Chahoud I. Effects of methyltestosterone on reproduction in the Japanese quail (Coturnix coturnix japonica). Environ Res. 2005;99:327-34 pubmed
    Although the hormone-mediated effects of the synthetic androgenic hormone methyltestosterone (MT) are well characterized in mammals, little is known about endocrine and other toxic effects on reproduction in birds...
  52. Blumel J, del Pino M, Aprikian D, Vallejo S, Sarra S, Castelo Branco C. Effect of androgens combined with hormone therapy on quality of life in post-menopausal women with sexual dysfunction. Gynecol Endocrinol. 2008;24:691-5 pubmed publisher
    ..0001). Adding methyl-testosterone to hormone therapy improves quality of life and sexuality in post-menopausal women with sexual dysfunction. ..