dehydroepiandrosterone sulfate

Summary

Summary: The circulating form of a major C19 steroid produced primarily by the ADRENAL CORTEX. DHEA sulfate serves as a precursor for TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE.

Top Publications

  1. Burel D, Li J, Do Rego J, Wang A, Luu The V, Pelletier G, et al. Gonadotropin-releasing hormone stimulates the biosynthesis of pregnenolone sulfate and dehydroepiandrosterone sulfate in the hypothalamus. Endocrinology. 2013;154:2114-28 pubmed publisher
    The sulfated neurosteroids pregnenolone sulfate (?(5)PS) and dehydroepiandrosterone sulfate (DHEAS) are known to play a role in the control of reproductive behavior...
  2. Lac G, Dutheil F, Brousse G, Triboulet Kelly C, Chamoux A. Saliva DHEAS changes in patients suffering from psychopathological disorders arising from bullying at work. Brain Cogn. 2012;80:277-81 pubmed publisher
    ..Psychological disorders arising from bullying at work (BW) are common. The relationship between these disorders and putative markers is not well established...
  3. Duszczyk Budhathoki M, Olczak M, Lehner M, Majewska M. Administration of thimerosal to infant rats increases overflow of glutamate and aspartate in the prefrontal cortex: protective role of dehydroepiandrosterone sulfate. Neurochem Res. 2012;37:436-47 pubmed publisher
    ..Coadministration of the neurosteroid, dehydroepiandrosterone sulfate (DHEAS; 80 mg/kg; i.p...
  4. Ikeda K, Saito T, Tojo K. Efonidipine, a Ca(2+)-channel blocker, enhances the production of dehydroepiandrosterone sulfate in NCI-H295R human adrenocortical carcinoma cells. Tohoku J Exp Med. 2011;224:263-71 pubmed
    ..the effects of CCBs on the expression of steroidogenic enzymes and the production of adrenal androgen, dehydroepiandrosterone sulfate (DHEA-S) that has anti-atherosclerotic actions...
  5. Cappola A, O Meara E, Guo W, Bartz T, Fried L, Newman A. Trajectories of dehydroepiandrosterone sulfate predict mortality in older adults: the cardiovascular health study. J Gerontol A Biol Sci Med Sci. 2009;64:1268-74 pubmed publisher
    b>Dehydroepiandrosterone sulfate (DHEAS) has been proposed as an antiaging hormone, but its importance is unclear...
  6. Morrison M, Freeman E, Lin H, Sammel M. Higher DHEA-S (dehydroepiandrosterone sulfate) levels are associated with depressive symptoms during the menopausal transition: results from the PENN Ovarian Aging Study. Arch Womens Ment Health. 2011;14:375-82 pubmed publisher
    ..Because dehydroepiandrosterone sulfate (DHEA-S) has been associated with several indicators of healthy aging, we conducted a population-based ..
  7. Chen M, Chen C, Yang J, Chen C, Ho H, Yang W, et al. High serum dehydroepiandrosterone sulfate is associated with phenotypic acne and a reduced risk of abdominal obesity in women with polycystic ovary syndrome. Hum Reprod. 2011;26:227-34 pubmed publisher
    ..The current study aims to determine if dehydroepiandrosterone sulfate (DHEAS) level is associated with the presence of acne and reduced risk of abdominal obesity in women ..
  8. Labrie F, Martel C, Balser J. Wide distribution of the serum dehydroepiandrosterone and sex steroid levels in postmenopausal women: role of the ovary?. Menopause. 2011;18:30-43 pubmed publisher
  9. Aldred S, Mecocci P. Decreased dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) concentrations in plasma of Alzheimer's disease (AD) patients. Arch Gerontol Geriatr. 2010;51:e16-8 pubmed publisher
    ..635 in controls and 0.467 in AD, p<or=0.01). This study highlighted a measurable difference in DHEA and DHEAS concentrations in plasma from a large cohort of patients suffering from AD when compared to age-matched controls. ..

Scientific Experts

More Information

Publications62

  1. Corvalan C, Uauy R, Mericq V. Obesity is positively associated with dehydroepiandrosterone sulfate concentrations at 7 y in Chilean children of normal birth weight. Am J Clin Nutr. 2013;97:318-25 pubmed publisher
    ..The objectives were to assess the associations between obesity indicators and dehydroepiandrosterone sulfate (DHEAS) at 7 y of age and to evaluate the role of hormonal markers on these associations...
  2. Genazzani A, Pluchino N. DHEA therapy in postmenopausal women: the need to move forward beyond the lack of evidence. Climacteric. 2010;13:314-6 pubmed publisher
    The marked age-related decline in serum dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) has suggested that a deficiency of these steroids may be causally related to the development of a series of diseases that are ..
  3. Phillips A, Carroll D, Gale C, Lord J, Arlt W, Batty G. Cortisol, DHEAS, their ratio and the metabolic syndrome: evidence from the Vietnam Experience Study. Eur J Endocrinol. 2010;162:919-23 pubmed publisher
    ..Prospective analyses are needed to help untangle direction of causality, but this study suggests that the cortisol:DHEAS ratio is worthy of further study in this and other health contexts. ..
  4. Romanowska J, Larsson G, Eriksson M, Wikström B, Westerlund H, Theorell T. Health effects on leaders and co-workers of an art-based leadership development program. Psychother Psychosom. 2011;80:78-87 pubmed publisher
    ..Positive results for both standardized questionnaires and biological parameters strengthened the findings. The study provides a rationale for further evaluation of the effectiveness of this alternative educational approach. ..
  5. Crawford S, Santoro N, Laughlin G, Sowers M, McConnell D, Sutton Tyrrell K, et al. Circulating dehydroepiandrosterone sulfate concentrations during the menopausal transition. J Clin Endocrinol Metab. 2009;94:2945-51 pubmed publisher
    A previous report from the Study of Women Across the Nation indicated a rise in dehydroepiandrosterone sulfate (DHEAS) during the menopausal transition using data from three annual visits...
  6. Jackowska M, Kumari M, Steptoe A. Sleep and biomarkers in the English Longitudinal Study of Ageing: associations with C-reactive protein, fibrinogen, dehydroepiandrosterone sulfate and hemoglobin. Psychoneuroendocrinology. 2013;38:1484-93 pubmed publisher
    ..Associations of sleep duration and sleep disturbance with C-reactive protein (CRP), fibrinogen, dehydroepiandrosterone sulfate (DHEAS) and hemoglobin were analyzed, adjusting for age, wealth, body mass index (BMI), smoking, ..
  7. Yoshida S, Aihara K, Azuma H, Uemoto R, Sumitomo Ueda Y, Yagi S, et al. Dehydroepiandrosterone sulfate is inversely associated with sex-dependent diverse carotid atherosclerosis regardless of endothelial function. Atherosclerosis. 2010;212:310-5 pubmed publisher
    b>Dehydroepiandrosterone sulfate (DHEAS) is thought to be associated with life expectancy and anti-aging. However, its biological significance in atherosclerosis remains controversial...
  8. Sanders J, Boudreau R, Cappola A, Arnold A, Robbins J, Cushman M, et al. Cardiovascular disease is associated with greater incident dehydroepiandrosterone sulfate decline in the oldest old: the cardiovascular health study all stars study. J Am Geriatr Soc. 2010;58:421-6 pubmed publisher
    To describe cross-sectional and longitudinal associations with dehydroepiandrosterone sulfate (DHEAS) and change in DHEAS with age. Longitudinal cohort study. Pittsburgh, Pennsylvania...
  9. Herrera J, Davidson J, Mestman J. Hyperandrogenism due to a testosterone-secreting Sertoli-Leydig cell tumor associated with a dehydroepiandrosterone sulfate-secreting adrenal adenoma in a postmenopausal woman: case presentation and review of literature. Endocr Pract. 2009;15:149-52 pubmed
    To report a case of hyperandrogenism attributable to the presence of an adrenal adenoma secreting dehydroepiandrosterone sulfate (DHEA-S) and an ovarian Sertoli-Leydig cell tumor secreting testosterone in a postmenopausal woman.
  10. Gadinger M, Loerbroks A, Schneider S, Thayer J, Fischer J. Associations between job strain and the cortisol/DHEA-S ratio among management and nonmanagement personnel. Psychosom Med. 2011;73:44-52 pubmed publisher
    ..main, nonlinear, and interactive effects of the demand-control-support (DCS) model and the cortisol/dehydroepiandrosterone sulfate (DHEA-S) ratio, a biomarker of psychophysical well-being...
  11. Miyajima M, Kusuhara H, Fujishima M, Adachi Y, Sugiyama Y. Organic anion transporter 3 mediates the efflux transport of an amphipathic organic anion, dehydroepiandrosterone sulfate, across the blood-brain barrier in mice. Drug Metab Dispos. 2011;39:814-9 pubmed publisher
    ..investigated the efflux transport systems of organic anions across the blood-brain barrier (BBB) using dehydroepiandrosterone sulfate (DHEAS) as a probe...
  12. Leskiewicz M, Jantas D, Budziszewska B, Lason W. Excitatory neurosteroids attenuate apoptotic and excitotoxic cell death in primary cortical neurons. J Physiol Pharmacol. 2008;59:457-75 pubmed
    ..The aim of the present study was to examine the effect of dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEAS), pregnenolone (PGL) and allopregnanolone (Allo) on staurosporine-, glutamate-, and NMDA-..
  13. Yoon S, Roh D, Seo H, Kang S, Moon J, Song S, et al. An increase in spinal dehydroepiandrosterone sulfate (DHEAS) enhances NMDA-induced pain via phosphorylation of the NR1 subunit in mice: involvement of the sigma-1 receptor. Neuropharmacology. 2010;59:460-7 pubmed publisher
    Our laboratory has recently demonstrated that an increase in the spinal neurosteroid, dehydroepiandrosterone sulfate (DHEAS) facilitates nociception via the activation of sigma-1 receptors and/or the allosteric inhibition GABA(A) ..
  14. Lowin T, Weidler C, Jenei Lanzl Z, Capellino S, Baerwald C, Buttgereit F, et al. Relationship between placenta growth factor 1 and vascularization, dehydroepiandrosterone sulfate to dehydroepiandrosterone conversion, or aromatase expression in patients with rheumatoid arthritis and patients with osteoarthritis. Arthritis Rheum. 2012;64:1799-808 pubmed publisher
    ..We undertook this study to investigate similarities between proliferating pannus and placental tissue by focusing on angiogenic placenta growth factor 1 (PlGF-1) in patients with OA and patients with RA...
  15. Lennartsson A, Kushnir M, Bergquist J, Jonsdottir I. DHEA and DHEA-S response to acute psychosocial stress in healthy men and women. Biol Psychol. 2012;90:143-9 pubmed publisher
    ..Furthermore, the results of this study suggest that the capacity to secrete DHEA and DHEA-S during acute psychosocial stress declines with age. ..
  16. Wang J, Chen S, Lee S, Lee S, Huang C, Hsieh C, et al. Dehydroepiandrosterone sulfate linked to physiologic response against hot spring immersion. Steroids. 2009;74:945-9 pubmed publisher
    The steroid dehydroepiandrosterone sulfate (DHEA-S) is associated with longevity and adaptation against external stress in humans...
  17. Zhai G, Teumer A, Stolk L, Perry J, Vandenput L, Coviello A, et al. Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms. PLoS Genet. 2011;7:e1002025 pubmed publisher
    ..Several SNPs were associated with changes in gene expression levels, and the related genes are connected to biological pathways linking DHEAS with ageing. This study provides much needed insight into the function of DHEAS. ..
  18. Phillips A, Carroll D, Gale C, Lord J, Arlt W, Batty G. Cortisol, DHEA sulphate, their ratio, and all-cause and cause-specific mortality in the Vietnam Experience Study. Eur J Endocrinol. 2010;163:285-92 pubmed publisher
    ..Further experimental study is needed to elucidate the mechanisms involved in these relationships. ..
  19. Moser U, Wadsak W, Spindelegger C, Mitterhauser M, Mien L, Bieglmayer C, et al. Hypothalamic serotonin-1A receptor binding measured by PET predicts the plasma level of dehydroepiandrosterone sulfate in healthy women. Neurosci Lett. 2010;476:161-5 pubmed publisher
    ..investigate the influence of the 5-HT(1A) receptor distribution in the human brain on plasma levels of dehydroepiandrosterone sulfate (DHEAS) and cortisol in vivo...
  20. Rennert A, Wittsiepe J, Kasper Sonnenberg M, Binder G, Fürst P, Cramer C, et al. Prenatal and early life exposure to polychlorinated dibenzo-p-dioxins, dibenzofurans and biphenyls may influence dehydroepiandrosterone sulfate levels at prepubertal age: results from the Duisburg birth cohort study. J Toxicol Environ Health A. 2012;75:1232-40 pubmed
    ..The samples were assayed for the sex hormones testosterone, estradiol, dehydroepiandrosterone sulfate (DHEA-S), and 17-OH-progesterone (17-OHP) by using an automated chemiluminescence assay system...
  21. Lerchbaum E, Schwetz V, Giuliani A, Pieber T, Obermayer Pietsch B. Opposing effects of dehydroepiandrosterone sulfate and free testosterone on metabolic phenotype in women with polycystic ovary syndrome. Fertil Steril. 2012;98:1318-25.e1 pubmed publisher
    ..To study the association of adrenal and ovarian androgen levels with metabolic parameters in a large cohort of women with polycystic ovary syndrome (PCOS)...
  22. Ohlsson C, Labrie F, Barrett Connor E, Karlsson M, Ljunggren O, Vandenput L, et al. Low serum levels of dehydroepiandrosterone sulfate predict all-cause and cardiovascular mortality in elderly Swedish men. J Clin Endocrinol Metab. 2010;95:4406-14 pubmed publisher
    ..64, 95% CI 1.37-5.09) than older men (HR 1.30, 95% CI 0.83-2.04). Low serum levels of DHEA(-S) predict death from all causes, CVD, and ischemic heart disease in older men. ..
  23. Radford D, Wang K, McNelis J, Taylor A, Hechenberger G, Hofmann J, et al. Dehydroepiandrosterone sulfate directly activates protein kinase C-beta to increase human neutrophil superoxide generation. Mol Endocrinol. 2010;24:813-21 pubmed publisher
    b>Dehydroepiandrosterone sulfate (DHEAS) is the most abundant steroid in the human circulation and is secreted by the adrenals in an age-dependent fashion, with maximum levels during the third decade and very low levels in old age...
  24. Utriainen P, Voutilainen R, Jääskeläinen J. Girls with premature adrenarche have accelerated early childhood growth. J Pediatr. 2009;154:882-7 pubmed publisher
    ..6 years). The growth variables were correlated with serum insulin-like growth factor (IGF)-1, dehydroepiandrosterone sulfate, and insulin concentrations...
  25. Maninger N, Wolkowitz O, Reus V, Epel E, Mellon S. Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS). Front Neuroendocrinol. 2009;30:65-91 pubmed publisher
    ..Accumulating data suggest abnormal DHEA and/or DHEAS concentrations in several neuropsychiatric conditions. The evidence that DHEA and DHEAS may be fruitful targets for pharmacotherapy in some conditions is reviewed. ..
  26. Shufelt C, Bretsky P, Almeida C, Johnson B, Shaw L, Azziz R, et al. DHEA-S levels and cardiovascular disease mortality in postmenopausal women: results from the National Institutes of Health--National Heart, Lung, and Blood Institute (NHLBI)-sponsored Women's Ischemia Syndrome Evaluation (WISE). J Clin Endocrinol Metab. 2010;95:4985-92 pubmed publisher
    b>Dehydroepiandrosterone sulfate (DHEA-S), a major circulating sex steroid prohormone, declines with age...
  27. Kellner M, Muhtz C, Peter F, Dunker S, Wiedemann K, Yassouridis A. Increased DHEA and DHEA-S plasma levels in patients with post-traumatic stress disorder and a history of childhood abuse. J Psychiatr Res. 2010;44:215-9 pubmed publisher
    ..Further studies are needed to clarify the potential role of DHEA and DHEA-S as biomarkers for severe early adverse events in patients suffering from PTSD and in other stress-related disorders. ..
  28. Pappa T, Vemmos K, Saltiki K, Mantzou E, Stamatelopoulos K, Alevizaki M. Severity and outcome of acute stroke in women: relation to adrenal sex steroid levels. Metabolism. 2012;61:84-91 pubmed publisher
    ..4-androstenedione levels were positively and dehydroepiandrosterone sulfate was inversely associated with stroke severity (r = 0.142, P = .014 and r = -0.153, P = ...
  29. Haring R, Volzke H, Felix S, Schipf S, Dorr M, Rosskopf D, et al. Prediction of metabolic syndrome by low serum testosterone levels in men: results from the study of health in Pomerania. Diabetes. 2009;58:2027-31 pubmed publisher
    The aim of this analysis was to assess the prospective association of serum testosterone and dehydroepiandrosterone sulfate (DHEAS) levels with incident metabolic syndrome (MetS) in men...
  30. Morgan C, Rasmusson A, Pietrzak R, Coric V, Southwick S. Relationships among plasma dehydroepiandrosterone and dehydroepiandrosterone sulfate, cortisol, symptoms of dissociation, and objective performance in humans exposed to underwater navigation stress. Biol Psychiatry. 2009;66:334-40 pubmed publisher
    A growing body of research has provided evidence that dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) are involved in an organism's response to stress and that it may provide beneficial behavioral and neurotrophic ..
  31. Ostrowska Z, Ziora K, Oswiecimska J, Swietochowska E, Wołkowska Pokrywa K.  Dehydroepiandrosterone sulfate, osteoprotegerin and its soluble ligand sRANKL and bone metabolism in girls with anorexia nervosa. Postepy Hig Med Dosw (Online). 2012;66:655-62 pubmed
    ..DHEAS suppression in girls with anorexia nervosa might have a harmful effect on their bone tissue, probably via a shift in the OPG/RANKL ratio toward a functional excess of sRANKL. ..
  32. Smit P, van Schaik R, van der Werf M, van den Beld A, Koper J, Lindemans J, et al. A common polymorphism in the CYP3A7 gene is associated with a nearly 50% reduction in serum dehydroepiandrosterone sulfate levels. J Clin Endocrinol Metab. 2005;90:5313-6 pubmed
    ..11 +/- 0.002 vs. 0.08 +/- 0.006 nmol/liter; P < 0.001). The CYP3A7*1C polymorphism causes the persistence of enzymatic activity of CYP3A7 during adult life, resulting in lower circulating DHEAS and estrone levels. ..
  33. George O, Vallée M, Le Moal M, Mayo W. Neurosteroids and cholinergic systems: implications for sleep and cognitive processes and potential role of age-related changes. Psychopharmacology (Berl). 2006;186:402-13 pubmed
    The neurosteroids pregnenolone sulfate (PREGS), dehydroepiandrosterone sulfate (DHEAS) and allopregnanolone (3alpha,5alpha THPROG) have been implicated as powerful modulators of memory processes and sleep states in young and aged subjects ..
  34. Mizota K, Yoshida A, Uchida H, Fujita R, Ueda H. Novel type of Gq/11 protein-coupled neurosteroid receptor sensitive to endocrine disrupting chemicals in mast cell line (RBL-2H3). Br J Pharmacol. 2005;145:545-50 pubmed
    ..6 Taken together, these results suggest that a G(q/11)-coupled neurosteroid receptor may regulate the neuroimmunological activity related to sensory stimulation and that some EDCs have antagonistic actions for this receptor. ..
  35. Tabuchi K, Murashita H, Tobita T, Oikawa K, Tsuji S, Uemaetomari I, et al. Dehydroepiandrosterone sulfate reduces acoustic injury of the guinea-pig cochlea. J Pharmacol Sci. 2005;99:191-4 pubmed
    The present study was performed to determine effects of dehydroepiandrosterone sulfate (DHEAS), a neurosteroid, on acoustic injury...
  36. Dalla Valle L, Toffolo V, Nardi A, Fiore C, Bernante P, Di Liddo R, et al. Tissue-specific transcriptional initiation and activity of steroid sulfatase complementing dehydroepiandrosterone sulfate uptake and intracrine steroid activations in human adipose tissue. J Endocrinol. 2006;190:129-39 pubmed
    ..Instead, our data support an intracrine role of adipose tissue, in which adrenal dehydroepiandrosterone sulfate (DHEA-S), the most abundant circulating androgen in man, is selectively uptaken, desulfated, and ..
  37. Altman R, Motton D, Kota R, Rutledge J. Inhibition of vascular inflammation by dehydroepiandrosterone sulfate in human aortic endothelial cells: roles of PPARalpha and NF-kappaB. Vascul Pharmacol. 2008;48:76-84 pubmed publisher
    b>Dehydroepiandrosterone sulfate (DHEAS) is a hormone produced by the adrenal gland and is a precursor for both androgens and estrogens...
  38. Kasperska Zajac A, Brzoza Z, Rogala B. Plasma concentration of interleukin 6 (IL-6), and its relationship with circulating concentration of dehydroepiandrosterone sulfate (DHEA-S) in patients with chronic idiopathic urticaria. Cytokine. 2007;39:142-6 pubmed
    ..However, no association between IL-6 and DHEA-S concentration in the peripheral circulation of CIU patients was proved, suggesting that both phenomena may not be related to each other. ..
  39. Nicolas L, Fry J. The steroid sulfatase inhibitor COUMATE attenuates rather than enhances access of dehydroepiandrosterone sulfate to the brain in the mouse. Brain Res. 2007;1174:92-6 pubmed
    Intraperitoneal injection of adult male mice with the neuroactive steroid dehydroepiandrosterone sulfate (DHEAS) at 1 and 40 mg/kg caused dose-dependent increases in the concentration of both this compound and its corresponding free ..
  40. Arnlov J, Pencina M, Amin S, Nam B, Benjamin E, Murabito J, et al. Endogenous sex hormones and cardiovascular disease incidence in men. Ann Intern Med. 2006;145:176-84 pubmed
    Data suggest that endogenous sex hormones (testosterone, dehydroepiandrosterone sulfate [DHEA-S], and estradiol) influence cardiovascular disease (CVD) risk factors and vascular function...
  41. Kauffman R, Baker V, Dimarino P, Castracane V. Hyperinsulinemia and circulating dehydroepiandrosterone sulfate in white and Mexican American women with polycystic ovary syndrome. Fertil Steril. 2006;85:1010-6 pubmed
    ..Hyperinsulinemia does not appear to significantly influence circulating adrenal androgen levels in PCOS. ..
  42. Markianos M, Panas M, Kalfakis N, Vassilopoulos D. Plasma testosterone, dehydroepiandrosterone sulfate, and cortisol in female patients with Huntington's disease. Neuro Endocrinol Lett. 2007;28:199-203 pubmed
    ..We assessed the plasma levels of the androgens total testosterone (TT) and dehydroepiandrosterone sulfate (DHEAS), as well as of cortisol in 41 female patients with HD, confirmed by determination of the CAG ..
  43. Kakugawa Y, Minami Y, Tateno H, Inoue H, Fujiya T. Relation of serum levels of estrogen and dehydroepiandrosterone sulfate to hormone receptor status among postmenopausal women with breast cancer. Breast Cancer. 2007;14:269-76 pubmed
    ..We measured serum levels of estrone (E1), estradiol (E2), dehydroepiandrosterone sulfate (DHEAS), and sex hormone-binding globulin (SHBG) in 142 postmenopausal women aged 50 and over with ..
  44. Sirianni R, Mayhew B, Carr B, Parker C, Rainey W. Corticotropin-releasing hormone (CRH) and urocortin act through type 1 CRH receptors to stimulate dehydroepiandrosterone sulfate production in human fetal adrenal cells. J Clin Endocrinol Metab. 2005;90:5393-400 pubmed
    Near term, the human fetal adrenal increases the production of cortisol and dehydroepiandrosterone sulfate (DHEAS). DHEAS, which acts as substrate for placental estrogen production, induces key changes involved in parturition...
  45. Fukui M, Kitagawa Y, Nakamura N, Kadono M, Yoshida M, Hirata C, et al. Serum dehydroepiandrosterone sulfate concentration and carotid atherosclerosis in men with type 2 diabetes. Atherosclerosis. 2005;181:339-44 pubmed
    ..0001) and of PS (beta = -0.301, P < 0.0001). In conclusion, serum DHEA-S concentration is negatively associated with carotid atherosclerosis determined by ultrasonographically evaluated IMT and PS in men with type 2 diabetes. ..
  46. Fischli S, Jenni S, Allemann S, Zwahlen M, Diem P, Christ E, et al. Dehydroepiandrosterone sulfate in the assessment of the hypothalamic-pituitary-adrenal axis. J Clin Endocrinol Metab. 2008;93:539-42 pubmed
    ..There is evidence that a z-score could be of diagnostic value in assessing HPA integrity, especially in younger patients and patients with pituitary macroadenoma, but further studies are needed to consolidate these findings. ..
  47. Chehab O, Ouertani M, Chaieb K, Haouala F, Mahdouani K. Hormonal status of cortisol and dehydroepiandrosterone sulfate in an elderly Tunisian population. C R Biol. 2007;330:755-63 pubmed
    Adrenal function and aging have been the object of intense interest recently, especially as regards dehydroepiandrosterone sulfate (DHEA-S), which is of major importance, since it is distinct from cortisol and aldosterone in declining ..
  48. Haren M, Malmstrom T, Banks W, Patrick P, Miller D, Morley J. Lower serum DHEAS levels are associated with a higher degree of physical disability and depressive symptoms in middle-aged to older African American women. Maturitas. 2007;57:347-60 pubmed
    ..There is an age-related decline in serum DHEAS in African American women. Lower DHEAS levels appear to be associated with a higher degree of physical disability and depressive symptoms in this population. ..
  49. Goodarzi M, Xu N, Azziz R. Association of CYP3A7*1C and serum dehydroepiandrosterone sulfate levels in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2008;93:2909-12 pubmed publisher
    ..Adult expression of CYP3A7 may modify the PCOS phenotype by ameliorating adrenal androgen excess. ..
  50. Dong L, Cheng Z, Fu Y, Wang Z, Zhu Y, Sun J, et al. Neurosteroid dehydroepiandrosterone sulfate enhances spontaneous glutamate release in rat prelimbic cortex through activation of dopamine D1 and sigma-1 receptor. Neuropharmacology. 2007;52:966-74 pubmed
    This paper studied the effect of neurosteroid dehydroepiandrosterone sulfate on spontaneous glutamate release in the prelimbic cortex by using electrophysiological and biochemical methods combined with a pharmacological approach and made ..
  51. Steffensen S, Jones M, Hales K, Allison D. Dehydroepiandrosterone sulfate and estrone sulfate reduce GABA-recurrent inhibition in the hippocampus via muscarinic acetylcholine receptors. Hippocampus. 2006;16:1080-90 pubmed
    ..We have previously demonstrated that endogenous and exogenous application of the neurosteroid dehydroepiandrosterone sulfate (DHEAS) markedly reduces GABA-mediated recurrent inhibition and synchronizes hippocampal unit activity ..
  52. Li Z, Zhou R, Cui S, Xie G, Cai W, Sokabe M, et al. Dehydroepiandrosterone sulfate prevents ischemia-induced impairment of long-term potentiation in rat hippocampal CA1 by up-regulating tyrosine phosphorylation of NMDA receptor. Neuropharmacology. 2006;51:958-66 pubmed
    We have reported that dehydroepiandrosterone sulfate (DHEAS) reduces the threshold for long-term potentiation (LTP) in Shaffer collateral-CA1 synapses through the amplification of Src-dependent NMDA receptor signaling...
  53. Hammer F, Subtil S, Lux P, Maser Gluth C, Stewart P, Allolio B, et al. No evidence for hepatic conversion of dehydroepiandrosterone (DHEA) sulfate to DHEA: in vivo and in vitro studies. J Clin Endocrinol Metab. 2005;90:3600-5 pubmed
    ..DHEAS does not seem to represent a circulating storage pool for DHEA regeneration, and therefore serum DHEAS is unlikely to reflect bioavailable DHEA. ..