Summary: A synthetic steroid that has anabolic and androgenic properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1194)

Top Publications

  1. Salvador J, Sanchez Baeza F, Marco M. Simultaneous immunochemical detection of stanozolol and the main human metabolite, 3'-hydroxy-stanozolol, in urine and serum samples. Anal Biochem. 2008;376:221-8 pubmed publisher
    Two enzyme-linked immunosorbent assays (ELISAs) have been established for the analysis of stanozolol (St) and 3'-hydroxy-stanozolol (3'OH-St), the main metabolite found in humans...
  2. Sheffer A, Fearon D, Austen K. Clinical and biochemical effects of stanozolol therapy for hereditary angioedema. J Allergy Clin Immunol. 1981;68:181-7 pubmed
    b>Stanozolol, an inexpensive anabolic steroid with a 30:1 anabolic:androgenic ratio, was administered to 12 male and 15 female patients with biochemically proven hereditary angioedema over a 2-yr period to obtain a systematic assessment of ..
  3. Höld K, Wilkins D, Crouch D, Rollins D, Maes R. Detection of stanozolol in hair by negative ion chemical ionization mass spectrometry. J Anal Toxicol. 1996;20:345-49 pubmed
    b>Stanozolol is an anabolic androgenic steroid occasionally abused by athletes. A sensitive, specific, and reproducible method for the quantitative determination of stanozolol in hair has been developed...
  4. Sloane D, Lee C, Sheffer A. Hereditary angioedema: Safety of long-term stanozolol therapy. J Allergy Clin Immunol. 2007;120:654-8 pubmed
    ..To assess the frequencies of various side effects of the attenuated androgen stanozolol in a population of patients with hereditary angioedema treated for 20 to 40 years...
  5. Kreuzer M, Quidant R, Salvador J, Marco M, Badenes G. Colloidal-based localized surface plasmon resonance (LSPR) biosensor for the quantitative determination of stanozolol. Anal Bioanal Chem. 2008;391:1813-20 pubmed publisher
    ..of interest, which in this case was a small organic molecule-the widely used, synthetic anabolic steroid called stanozolol. For this system, high specificity was achieved (>97%) through extensive nonspecific binding tests, with a ..
  6. Pozo O, Van Eenoo P, Deventer K, Lootens L, Grimalt S, Sancho J, et al. Detection and structural investigation of metabolites of stanozolol in human urine by liquid chromatography tandem mass spectrometry. Steroids. 2009;74:837-52 pubmed publisher
    The applicability of LC-MS/MS in precursor ion scan mode for the detection of urinary stanozolol metabolites has been studied...
  7. Pey A, Saborido A, Blázquez I, Delgado J, Megías A. Effects of prolonged stanozolol treatment on antioxidant enzyme activities, oxidative stress markers, and heat shock protein HSP72 levels in rat liver. J Steroid Biochem Mol Biol. 2003;87:269-77 pubmed
    ..aimed at testing whether prolonged (8 weeks) treatment with high doses (2 mg kg(-1) body weight; 5 d wk(-1)) of stanozolol (ST), either alone or in conjunction with treadmill-exercise training, induced changes in oxidative stress ..
  8. Saborido A, Naudi A, Portero Otin M, Pamplona R, Megías A. Stanozolol treatment decreases the mitochondrial ROS generation and oxidative stress induced by acute exercise in rat skeletal muscle. J Appl Physiol (1985). 2011;110:661-9 pubmed publisher
    ..ROS) production, we investigated the potential effects of a treatment with the anabolic androgenic steroid stanozolol against oxidative damage induced on rat skeletal muscle mitochondria by an acute bout of exhaustive exercise...
  9. Chimento A, Sirianni R, Zolea F, De Luca A, Lanzino M, Catalano S, et al. Nandrolone and stanozolol induce Leydig cell tumor proliferation through an estrogen-dependent mechanism involving IGF-I system. J Cell Physiol. 2012;227:2079-88 pubmed publisher
    ..In this study we aimed to determine if nandrolone and stanozolol, two commonly used AAS, could have an effect on Leydig cell tumor proliferation and if their effects could be ..

More Information


  1. Masonis A, McCarthy M. Direct interactions of androgenic/anabolic steroids with the peripheral benzodiazepine receptor in rat brain: implications for the psychological and physiological manifestations of androgenic/anabolic steroid abuse. J Steroid Biochem Mol Biol. 1996;58:551-5 pubmed
    ..Two synthetic AAS, stanozolol and 17beta-testosterone cypionate (17beta-cyp), significantly inhibited 1 nM [3H] PK11195 binding at ..
  2. Lau D, Stiles M, John B, Shashidhar -, Young G, Sanders P. Atrial fibrillation and anabolic steroid abuse. Int J Cardiol. 2007;117:e86-7 pubmed
    ..Several predisposing substrates such as increasing age, heart failure, hypertension and valvular heart disease have been identified. The use of illicit drugs as the substrate for AF is not frequently recognized. ..
  3. Socas L, Zumbado M, Perez Luzardo O, Ramos A, Perez C, Hernandez J, et al. Hepatocellular adenomas associated with anabolic androgenic steroid abuse in bodybuilders: a report of two cases and a review of the literature. Br J Sports Med. 2005;39:e27 pubmed
    ..Consequently, they should be carefully and periodically monitored with US studies. In any case, despite the size of the tumours detected in these two cases, the possibility of spontaneous tumour regression must also be taken in account. ..
  4. Ahi S, Beotra A, Jain S. Detection of mono-hydroxylated metabolites of stanozolol by HPLC-ESI (+) MS/MS in Indian sports persons. Drug Test Anal. 2009;1:538-44 pubmed publisher
    The abuse of stanozolol is quite widespread in Indian sport. Its analysis is challenging and this has led to the development of new methods to improve its detection...
  5. Grattan C, Humphreys F. Guidelines for evaluation and management of urticaria in adults and children. Br J Dermatol. 2007;157:1116-23 pubmed
    ..As many of the recommendations relate to the off-licence use of drugs, it is particularly important that clinicians should be familiar with dosing and side-effects of treatment in the context of managing urticaria. ..
  6. Skoura C, Mourouzis C, Saranteas T, Chatzigianni E, Tesseromatis C. Masseteric hypertrophy associated with administration of anabolic steroids and unilateral mastication: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001;92:515-8 pubmed
    ..The combined action of unilateral mastication and anabolic steroid use is probably responsible for the rapid development of unilateral masseteric hypertrophy. ..
  7. Thevis M, Makarov A, Horning S, Schanzer W. Mass spectrometry of stanozolol and its analogues using electrospray ionization and collision-induced dissociation with quadrupole-linear ion trap and linear ion trap-orbitrap hybrid mass analyzers. Rapid Commun Mass Spectrom. 2005;19:3369-78 pubmed
    ..The fragmentation behavior of stanozolol, its metabolites 17-epistanozolol, 3'-OH-stanozolol, 4alpha-OH-stanozolol, 4beta-OH-stanozolol, 17-epi-16alpha-..
  8. Kreuzer M, Quidant R, Badenes G, Marco M. Quantitative detection of doping substances by a localised surface plasmon sensor. Biosens Bioelectron. 2006;21:1345-9 pubmed
    ..Our approach uses a simple method for the quantitative determination of an anabolic agent called stanozolol (Sz)...
  9. Konerding M, Ziebart T, Wolloscheck T, Wellmann A, Ackermann M. Impact of single-dose application of TGF-?, copper peptide, stanozolol and ascorbic acid in hydrogel on midline laparatomy wound healing in a diabetic mouse model. Int J Mol Med. 2012;30:271-6 pubmed publisher
    ..The aim of this study was to investigate possible effects of single application of ascorbic acid, stanozolol, a synthetic anabolic steroid, copper peptide and transforming growth factor-? (TGF-?) on laparotomy wound ..
  10. Lionikas A, Blizard D. Diverse effects of stanozolol in C57BL/6J and A/J mouse strains. Eur J Appl Physiol. 2008;103:333-41 pubmed publisher
    ..mimicking implantation of steroids; CTRL-AAS, mice similarly housed and implanted with a pellet containing stanozolol (release rate, 4...
  11. Draisci R, Palleschi L, Marchiafava C, Ferretti E, Delli Quadri F. Confirmatory analysis of residues of stanozolol and its major metabolite in bovine urine by liquid chromatography-tandem mass spectrometry. J Chromatogr A. 2001;926:69-77 pubmed
    A reliable method for the confirmation of the synthetic hormone stanozolol and its major metabolite, 16beta-hydroxystanozolol, in bovine urine by liquid chromatography coupled with tandem mass spectrometry has been developed...
  12. Barros T, Santos M, Shinozaki E, Santos J, Marchini L. Effects of use of anabolic steroids on the masticatory system: a pilot study. J Oral Sci. 2008;50:19-24 pubmed
    ..020, Mann-Whitney test) and Angle Class II malocclusion, compared to the non-users. These results suggested that the use of AAS alters masticatory structures and increases the incidence of TMD. ..
  13. Habscheid W, Abele U, Dahm H. [Severe cholestasis with kidney failure from anabolic steroids in a body builder]. Dtsch Med Wochenschr. 1999;124:1029-32 pubmed
    ..taking moderately high doses of anabolic steroids: metandienone (methandienone), 10-50 mg daily by mouth, and stanozolol, 50 mg intramuscularly every other day...
  14. Kong X, Feng Y. [Clinical report on treatment of 7 patients with refractory anemia by using cyclosporin A]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2004;12:697-8 pubmed
    ..myelodysplastic syndrome (subtype of refractory anemia) were treated in combination of cyclosporin A (CsA) with stanozolol. Duration of treatment with CsA was 5 months-3 years (mean 13 months)...
  15. Stimac D, Milić S, Dintinjana R, Kovac D, Ristic S. Androgenic/Anabolic steroid-induced toxic hepatitis. J Clin Gastroenterol. 2002;35:350-2 pubmed
    ..month before admission to the hospital, he used testosterone enanthate (500 mg intramuscularly, twice weekly), stanozolol (40 mg/d), and methylandrostenediol (30 mg/d by mouth, for 5 weeks)...
  16. Loncarek K. Sports medicine update. Scand J Med Sci Sports. 2002;12:323 pubmed
  17. Parsad D, Pandhi R, Juneja A. Stanozolol in chronic urticaria: a double blind, placebo controlled trial. J Dermatol. 2001;28:299-302 pubmed
    ..To evaluate the role of stanozolol as an adjunctive therapeutic agent with H1-antihistamine in refractory chronic idiopathic urticaria, we ..
  18. Feldkoren B, Andersson S. Anabolic-androgenic steroid interaction with rat androgen receptor in vivo and in vitro: a comparative study. J Steroid Biochem Mol Biol. 2005;94:481-7 pubmed
    ..affinities for the AR that are higher than that of the natural androgen testosterone, while others such as stanozolol and methanedienone have significantly lower affinities as compared with testosterone...
  19. Welder A, Robertson J, Melchert R. Toxic effects of anabolic-androgenic steroids in primary rat hepatic cell cultures. J Pharmacol Toxicol Methods. 1995;33:187-95 pubmed doses of 1 x 10(-8), 1 x 10(-6), and 1 x 10(-4)M 19-nortestosterone, fluoxymesterone, testosterone cypionate, stanozolol, danazol, oxymetholone, testosterone, estradiol, and methyltestosterone for 1, 4, and 24 hr...
  20. Jakez Ocampo J, Richaud Patin Y, Llorente L. Lupus nephritis remission, albeit with positive anti-doping test. Joint Bone Spine. 2007;74:96-7 pubmed
    ..Instead, she took her bodybuilding trainer's advice of one intramuscular injection of stanozolol for 10 weeks in order to increase her gluteus area...
  21. Kintz P, Cirimele V, Sachs H, Jeanneau T, Ludes B. Testing for anabolic steroids in hair from two bodybuilders. Forensic Sci Int. 1999;101:209-16 pubmed
    ..Urine and hair specimens were collected from both suspects to clarify the claims. Nandrolone, stanozolol, testosterone and their corresponding metabolites were identified in the urine of both subjects...
  22. Zhu S, Li Y, Ma H, Huang T, Luo H, Dou J, et al. Stanozolol regulates proliferation of growth plate chondrocytes via activation of ERalpha in GnRHa-treated adolescent rats. J Pediatr Endocrinol Metab. 2011;24:275-81 pubmed
    Improving the final adult height is one of the most important aims for treatment of central precocious puberty. Stanozolol (ST) is a synthetic derivative of androgen...
  23. Kumar M, Gupta C. Acquired angioedema secondary to hormone replacement therapy. Indian J Med Sci. 2005;59:451-4 pubmed
    ..To the best of our knowledge, this case probably represents the first reported case of acquired angioedema secondary to hormone replacement therapy. ..
  24. Tölgyesi A, Sharma V, Fekete J. Confirmatory analysis of stanozolol metabolites in bovine, pig and sheep urines using an optimized clean-up and liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal. 2014;88:45-52 pubmed publisher
    ..describes a new liquid chromatography-tandem mass spectrometric (LC-MS/MS) method for the analysis of three stanozolol metabolites (16?-hydroxystanozolol, 3'-hydroxystanozolol, and 4?-hydroxystanozolol) in urines of animal origins...
  25. Breuer M, McGinnis M, Lumia A, Possidente B. Aggression in male rats receiving anabolic androgenic steroids: effects of social and environmental provocation. Horm Behav. 2001;40:409-18 pubmed
    ..Three AAS were tested in gonadally intact male rats: testosterone propionate (TP), nandrolone (ND), and stanozolol (ST)...
  26. Zhang X, Xu Y, Jin J, Zhang X, Zhang L, Su A. Clinical observation on treatment of chronic aplastic anemia by Shengxuening and cyclosporin A. Chin J Integr Med. 2006;12:142-5 pubmed
    ..01), and showed significant difference from those in the control group (P < 0.05). Shengxuening-assisting CsA therapy is an effective measure for treatment of CAA. ..
  27. Bi H, Masse R, Just G. Studies on anabolic steroids. 9. Tertiary sulfates of anabolic 17 alpha-methyl steroids: synthesis and rearrangement. Steroids. 1992;57:306-12 pubmed
    ..The sulfates of methandienone, 17 alpha-methyltestosterone, mestanolone, oxandrolone, and stanozolol were prepared. Different A-ring functions were not affected under the sulfation condition...
  28. Martinez B, Velasco M, Pozo A, Benlloch S, Berenguer J. [Cholestatic injury by stanozolol intake]. Rev Esp Enferm Dig. 2006;98:219-20 pubmed
  29. Santamarina R, Besocke A, Romano L, Ioli P, Gonorazky S. Ischemic stroke related to anabolic abuse. Clin Neuropharmacol. 2008;31:80-5 pubmed publisher
    ..His only significant risk factor was nonmedical use of stanozolol, an anabolic steroid...
  30. Boehmer A, Brinkmann A, Nijman R, Verleun Mooijman M, de Ruiter P, Niermeijer M, et al. Phenotypic variation in a family with partial androgen insensitivity syndrome explained by differences in 5alpha dihydrotestosterone availability. J Clin Endocrinol Metab. 2001;86:1240-6 pubmed
    ..The distinct phenotypic variation in AIS here is explained by differences in the availability of 5alpha-dihydrotestosterone during embryonic sex differentiation...
  31. Choi M, Chung B. N-isobutyloxycarbonylation for improved detection of 3'-hydroxystanozolol and its 17-epimer in doping control. Analyst. 2001;126:306-9 pubmed
    ..pentane extraction of many steroids from urine in doping control, but it was not suitable for the detection of stanozolol metabolites...
  32. Inamdar Doddamani L, Jayamma Y. Acceleration of neutrophil precursors' maturation and immunostimulation of CD3+, CD4+ lymphocytes by stanozolol in mice. J Steroid Biochem Mol Biol. 2012;129:172-8 pubmed publisher
    ..The present study aims to evaluate the short-term effect of an AAS compound stanozolol, on lipoprotein profile, granulopoiesis and immune response in adult female mice...
  33. Stewart R, McKinney A, Kerwick C, Young E, Vadasz A, Cade I, et al. Metabolism of stanozolol: chemical synthesis and identification of a major canine urinary metabolite by liquid chromatography-electrospray ionisation ion trap mass spectrometry. J Steroid Biochem Mol Biol. 2009;117:152-8 pubmed publisher
    The canine phase I and phase II metabolism of the synthetic anabolic-androgenic steroid stanozolol was investigated following intramuscular injection into a male greyhound...
  34. Matrisciano F, Modafferi A, Togna G, Barone Y, Pinna G, Nicoletti F, et al. Repeated anabolic androgenic steroid treatment causes antidepressant-reversible alterations of the hypothalamic-pituitary-adrenal axis, BDNF levels and behavior. Neuropharmacology. 2010;58:1078-84 pubmed publisher
    ..As a model of AAS abuse, we used male adult rats injected for 4 weeks with either nandrolone or stanozolol at daily doses (5 mg/kg, s.c...
  35. Nebot E, Aparicio V, Camiletti Moirón D, Martinez R, Erben R, Kapravelou G, et al. Stanozolol Decreases Bone Turnover Markers, Increases Mineralization, and Alters Femoral Geometry in Male Rats. Calcif Tissue Int. 2016;98:609-18 pubmed publisher
    ..In spite of an absence of changes in BMD, geometric metaphyseal changes were observed. We conclude that ST alters bone geometry, leads to low bone turnover, and thus may impair bone quality. ..
  36. Nielen M, van Engelen M, Zuiderent R, Ramaker R. Screening and confirmation criteria for hormone residue analysis using liquid chromatography accurate mass time-of-flight, Fourier transform ion cyclotron resonance and orbitrap mass spectrometry techniques. Anal Chim Acta. 2007;586:122-9 pubmed
    ..and confirmation of targeted analytes and for the identification of unknowns using the anabolic steroid stanozolol and the designer beta-agonist "Clenbuterol-R" as model substances...
  37. Ballard C, Wood R. Intracerebroventricular self-administration of commonly abused anabolic-androgenic steroids in male hamsters (Mesocricetus auratus): nandrolone, drostanolone, oxymetholone, and stanozolol. Behav Neurosci. 2005;119:752-8 pubmed
    ..the authors compared icv self-administration of 4 anabolic steroids (drostanolone, nandrolone, oxymetholone, and stanozolol) at 0.1, 1.0, and 2.0 microg/microl, each for 8 days...
  38. Clark A, Harrold E, Fast A. Anabolic-androgenic steroid effects on the sexual behavior of intact male rats. Horm Behav. 1997;31:35-46 pubmed
    ..AAS compounds analyzed in this study were 17alpha-methyltestosterone, methandrostenolone, nandrolone decanoate, stanozolol, oxymetholone, and testosterone cypionate...
  39. Felzmann W, Gmeiner G, Gärtner P. First synthesis of a pentadeuterated 3'-hydroxystanozolol--an internal standard in doping analysis. Steroids. 2005;70:103-10 pubmed used as an internal standard in screening procedures for anabolic steroids as well as for the quantification of stanozolol metabolites via mass spectrometric techniques, such as LC-MS or gas chromatography-mass spectrometry (GC-MS).
  40. Ong S, Harrow C, Devgun M, Field M. Cryofibrinogenaemia complicated by amyloidosis: a new association. Rheumatology (Oxford). 2003;42:797-8 pubmed
  41. Huenerbein A, Sipoli Marques M, Pereira A, de Aquino Neto F. Improvement in steroid screening for doping control with special emphasis on stanozolol. J Chromatogr A. 2003;985:375-86 pubmed
    ..Later. eluting analytes, such as the stanozolol metabolites, furazabol and oxandrolone were not affected. Temperatures below 140 degrees C...
  42. Kailin X, Yushu H, Qingchao W, Yuanbo L. Hyperinsulinemia accompanying hyperglycemia in Chinese patients with aplastic anemia. Am J Hematol. 1997;56:151-4 pubmed
    ..Serum insulin and plasma glucose levels in 27 cases previously treated with stanozolol were significantly higher than those in the newly diagnosed cases and the previously treated cases with ..
  43. Redondo P, Molano E, Lloret P, Bauza A. 'Skin popping' ulceration in an HIV patient. Successful treatment with antiretroviral drugs and stanozolol. Int J STD AIDS. 2002;13:508-9 pubmed
    ..Treatment with antiretroviral drugs and stanozolol was associated with a striking clinical improvement of the ulcer in two weeks...
  44. McGinnis M, Lumia A, Breuer M, Possidente B. Physical provocation potentiates aggression in male rats receiving anabolic androgenic steroids. Horm Behav. 2002;41:101-10 pubmed
    ..Animals received 5 mg/kg testosterone propionate (TP), nandrolone (ND), or stanozolol (ST) 5 days/week. Controls received vehicle injections...
  45. Roselli C. The effect of anabolic-androgenic steroids on aromatase activity and androgen receptor binding in the rat preoptic area. Brain Res. 1998;792:271-6 pubmed
    ..In contrast, the 17alpha-alkylated compounds that were tested (stanozolol, danazol, methandrostenolone) modestly stimulated aromatase and were weak competitors for the androgen receptor...
  46. Winwood P, Robertson D, Wright R. Bleeding oesophageal varices associated with anabolic steroid use in an athlete. Postgrad Med J. 1990;66:864-5 pubmed
    ..We report what is, to our knowledge, the first case of bleeding oesophageal varices associated with the use of anabolic steroids. ..
  47. Mishra S, Mishra R, Sahu B, Nayak L, Senga Y. Differential growth of the freshwater mussel, Lamellidens marginalis in relation to certain drugs. Environ Toxicol. 2008;23:379-86 pubmed publisher
    ..05. The regression analysis was adopted to find out the coefficient of determination (R(2)=0.90, being the best) from the relationship between length and weight of mussels and to establish the LWR equation with condition factor k=W/L(b). ..
  48. Pieretti S, Mastriota M, Tucci P, Battaglia G, Trabace L, Nicoletti F, et al. Brain nerve growth factor unbalance induced by anabolic androgenic steroids in rats. Med Sci Sports Exerc. 2013;45:29-35 pubmed publisher
    ..Male Wistar rats were injected for 4 wk with either nandrolone or stanozolol at daily doses (5.0 mg·kg(-1), s.c.) that are considered equivalent to those abused by humans...
  49. Tucci P, Morgese M, Colaianna M, Zotti M, Schiavone S, Cuomo V, et al. Neurochemical consequence of steroid abuse: stanozolol-induced monoaminergic changes. Steroids. 2012;77:269-75 pubmed publisher
    ..Recently it has been reported that in a rat model of AAS abuse stanozolol induces behavioural and biochemical changes related to the pathophysiology of major depressive disorder...
  50. Delorme N, Drouet M, Thibaudeau A, Verret J. [Cold-induced urticaria]. Allerg Immunol (Paris). 2002;34:255-8 pubmed
    ..Doxepin may be useful in the treatment. Leukotriene receptor antagonists may be a novel, promising drug entity. In patients who do not respond to previous treatments, induction of cold tolerance may be tried. ..
  51. Farrell S, McGinnis M. Long-term effects of pubertal anabolic-androgenic steroid exposure on reproductive and aggressive behaviors in male rats. Horm Behav. 2004;46:193-203 pubmed
    ..Animals received 5 mg/kg of testosterone, nandrolone, stanozolol, or vehicle, beginning at puberty. After 5 weeks, behavior tests were performed while continuing AAS injections...
  52. Mateus Avois L, Mangin P, Saugy M. Use of ion trap gas chromatography-multiple mass spectrometry for the detection and confirmation of 3'hydroxystanozolol at trace levels in urine for doping control. J Chromatogr B Analyt Technol Biomed Life Sci. 2005;816:193-201 pubmed
    b>Stanozolol, a synthetic anabolic androgenic steroid, is often abused in sports to enhance performance...
  53. Wang S, Wei Y, Du H, Ren L, Li S. [Clinical efficacy and T-lymphocyte subset, serum interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha), interleukin-2(IL-2) levels on treatment of chronic aplastic anemia patients by shenfu injection combined with stanozol and cyclos. Zhongguo Zhong Yao Za Zhi. 2005;30:383-5 pubmed