tinospora

Summary

Summary: A plant genus of the family MENISPERMACEAE. Members have been used in AYURVEDIC MEDICINE. Hypoglycemic effect has been reported.

Webpages

  1. current science - contents
    www.iisc.ernet.in/currsci/jan102007/contents.htm
  2. complications of diabetes ; seattle washington wa
    www.swedish.org/111687.cfm
  3. complications of diabetes ; seattle washington wa
    www.swedish.org/111687.cfm#ref17
  4. complications of diabetes ; seattle washington wa
    www.swedish.org/111687.cfm#ref29
  5. king edward memorial hospital - departments: clinical pharmacology
    www.kem.edu/dept/clinical_pharmacology/UG_awardwin.htm

Publications

  1. Prevention of experimental diabetic cataract by Indian Ayurvedic plant extracts
    S S Rathi
    Department of Pharmacology, Dr Rajendra Prasad Center of Ophthalmic Sciences, All India Institute of Medical Sciences, Ansari Nagar, New Delhi - 110029, India
    Phytother Res 16:774-7
  2. Hypoglycaemic and hypolipidaemic action of alcohol extract of Tinospora cordifolia roots in chemical induced diabetes in rats
    P Stanely Mainzen Prince
    Department of Biochemistry, Annamalai University, Annamalainagar - 608 002, Tamil Nadu, India
    Phytother Res 17:410-3
  3. Anti-inflammatory activity, cytotoxicity and active compounds of Tinospora smilacina Benth
    Rachel W Li
    Division of Medical Technology, John A Burns School of Medicine, University of Hawaii 96822, USA
    Phytother Res 18:78-83
  4. Role of selected Indian plants in management of type 2 diabetes: a review
    Abha Saxena
    Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
    J Altern Complement Med 10:369-78
  5. Alteration of lethal effects of gamma rays in Swiss albino mice by Tinospora cordifolia
    Subhash Pahadiya
    Department of Zoology, University of Rajasthan, Jaipur 302004, India
    Phytother Res 17:552-4
  6. Restoration of antioxidants by ethanolic Tinospora cordifolia in alloxan-induced diabetic Wistar rats
    Ponnaian Stanely Mainzen Prince
    Department of Biochemistry, Annamalai University, Annamalainagar-608 002, Tamil Nadu, India
    Acta Pol Pharm 61:283-7
  7. Restoration of antioxidant defence by ethanolic Tinospora cordifolia root extract in alloxan-induced diabetic liver and kidney
    P Stanely Mainzen Prince
    Department of Biochemistry, Annamalai University, Annamalainagar, Tamil Nadu, India
    Phytother Res 18:785-7
  8. Protective effect of a polyherbal formulation (Immu-21) against cyclophosphamide-induced mutagenicity in mice
    G B Jena
    Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Sector-67, S A S Nagar, Punjab 160 062, India
    Phytother Res 17:306-10
  9. Inhibitory effect of a polysaccharide from Tinospora cordifolia on experimental metastasis
    P V Leyon
    Department of Immunology, Amala Cancer Research Centre, Amala Nagar PO, Thrissur Dt, Kerala 680 553, India
    J Ethnopharmacol 90:233-7
  10. Tinospora cordifolia as an adjuvant drug in the treatment of hyper-reactive malarious splenomegaly--case reports
    Ranjan Kumar Singh
    District Hospital, Daltonganj, Jharkhand, India
    J Vector Borne Dis 42:36-8

Scientific Experts

  • J K Grover
  • Meghna R Adhvaryu
  • Sweta Prasad
  • Gyana Ranjan Rout
  • Subrata Chattopadhyay
  • Ganesh Chandra Jagetia
  • G Roja
  • R P Singh
  • Subhash Pahadiya
  • P R Usha
  • Musliarakathbacker Jahfar
  • Abha Saxena
  • Avinash K Rawal
  • Rakesh Maurya
  • Rachel W Li
  • N N Rege
  • Nisha Singh
  • Sukh Mahendra Singh
  • T S Panchabhai
  • Wei Li
  • P K Raveendran Nair
  • P V Leyon
  • P Stanely Mainzen Prince
  • Mahesh Subramanian
  • Qirong Shi
  • Pratima Shrivastava
  • Harish Chandra Goel
  • Gajanan J Chintalwar
  • G Thippeswamy
  • P Kapur
  • Ranu Chaudhary
  • Harshad Purandare
  • Guillaume Denis
  • Lakshman Singh
  • Veena R Desai
  • Yan Yu
  • Weidong Zhang
  • S M Ahmed
  • D Samuel Sudhakaran
  • Yufeng Zhang
  • Kazuo Koike
  • Pragada Rajeswara Rao
  • Steven J Melnick
  • Reshma Ramachandran
  • V A Badar
  • Enrique Escalon
  • Cheppail Ramachandran
  • Chawanya Sangsuwan
  • G Kuttan
  • Sham Diwanay
  • Ponnaian Stanely Mainzen Prince
  • Venugopal P Menon
  • L R Zafinindra
  • R S Gupta
  • S A Tasaduq
  • G B Jena
  • E Bassene
  • B Faye
  • Ngampong Kongkathip
  • H C Goel
  • O Thioune
  • Biswadev Bishayi
  • S S Rathi
  • A S Joshi
  • D Seidlova-Wuttke
  • B D Samant
  • U P Kulkarni
  • W Wuttke
  • S V Ambarkhane
  • B M J Pereira
  • H Jarry
  • Swafiya Jahan
  • Bharathi P Salimath
  • P K Goyal
  • M L Sheela
  • D Seidlova Wuttke
  • Yunheng Shen
  • Qiongqun Pan
  • Bertrand Riff
  • Xiaolin Wang
  • Nathalie Viget
  • Moshahid Alam Rizvi
  • Kun Wei
  • Sonia Tyagi
  • Zhi-Biao Yi
  • Avinash Supe
  • Yi-Zeng Liang
  • Chunlin Chen
  • Chuan Zhang
  • Mingjin Liang
  • Sevser Sahpaz
  • K B Sainis
  • Yi Zeng Liang
  • RunHui Liu
  • Hongwei Fu
  • HuiLiang Li
  • Xiangwei Wang
  • Rupal Ramkrishnan
  • Zhi biao Yi
  • Yiyu Cheng
  • R Dinakaran Michael
  • L D Devasree
  • S Premsingh
  • Peiying Shi
  • L R Manhas
  • R K Khajuria
  • V Verma
  • P Srirekha
  • Gottumukkala Venkata Subbaraju
  • Routhu Kasi Viswanath
  • M P Shrivastava
  • L L Hingorani
  • Veeravalli Krishna Kumar
  • V R Thawani
  • Gajendra Singh
  • P T Wakode
  • K J Gharpure
  • R M Khiyani
  • Lianbo Lin
  • Yingjie Chen

Detail Information

Webpages7

  1. current science - contents
    www.iisc.ernet.in/currsci/jan102007/contents.htm
  2. complications of diabetes ; seattle washington wa
    www.swedish.org/111687.cfm
  3. complications of diabetes ; seattle washington wa
    www.swedish.org/111687.cfm#ref17
  4. complications of diabetes ; seattle washington wa
    www.swedish.org/111687.cfm#ref29
  5. king edward memorial hospital - departments: clinical pharmacology
    www.kem.edu/dept/clinical_pharmacology/UG_awardwin.htm

Publications60

  1. Prevention of experimental diabetic cataract by Indian Ayurvedic plant extracts
    S S Rathi
    Department of Pharmacology, Dr Rajendra Prasad Center of Ophthalmic Sciences, All India Institute of Medical Sciences, Ansari Nagar, New Delhi - 110029, India
    Phytother Res 16:774-7
    The efficacy of Momordica charantia (MC), Eugenia jambolana (EJ), Tinospora cordifolia (TC) and Mucuna pruriens (MP) was assessed in the prevention of murine alloxan dibetic cataract...
  2. Hypoglycaemic and hypolipidaemic action of alcohol extract of Tinospora cordifolia roots in chemical induced diabetes in rats
    P Stanely Mainzen Prince
    Department of Biochemistry, Annamalai University, Annamalainagar - 608 002, Tamil Nadu, India
    Phytother Res 17:410-3
    ..investigation was undertaken to evaluate the hypoglycaemic and hypolipidaemic effects of an alcohol extract of Tinospora cordifolia roots, an indigenous plant used in Ayurvedic medicine in India...
  3. Anti-inflammatory activity, cytotoxicity and active compounds of Tinospora smilacina Benth
    Rachel W Li
    Division of Medical Technology, John A Burns School of Medicine, University of Hawaii 96822, USA
    Phytother Res 18:78-83
    b>Tinospora smilacina Benth. has been used in Australian indigenous medicine for the treatment of headache, rheumatoid arthritis and other inflammatory disorders...
  4. Role of selected Indian plants in management of type 2 diabetes: a review
    Abha Saxena
    Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
    J Altern Complement Med 10:369-78
    ..Mechanisms such as the stimulating or regenerating effect on beta cells or extrapancreatic effects are proposed for the hypoglycemic action of these herbs...
  5. Alteration of lethal effects of gamma rays in Swiss albino mice by Tinospora cordifolia
    Subhash Pahadiya
    Department of Zoology, University of Rajasthan, Jaipur 302004, India
    Phytother Res 17:552-4
    b>Tinospora cordifolia is widely used in Ayurvedic medicines. It is known for its immunomodulatory, antihepatotoxic, antistress and antioxidant properties...
  6. Restoration of antioxidants by ethanolic Tinospora cordifolia in alloxan-induced diabetic Wistar rats
    Ponnaian Stanely Mainzen Prince
    Department of Biochemistry, Annamalai University, Annamalainagar-608 002, Tamil Nadu, India
    Acta Pol Pharm 61:283-7
    The present study investigates the effect of oral administration of an alcoholic extract of Tinospora cordifolia roots on antioxidant defence in alloxan-induced diabetes in rats...
  7. Restoration of antioxidant defence by ethanolic Tinospora cordifolia root extract in alloxan-induced diabetic liver and kidney
    P Stanely Mainzen Prince
    Department of Biochemistry, Annamalai University, Annamalainagar, Tamil Nadu, India
    Phytother Res 18:785-7
    The present study investigates the effect of oral administration of an alcoholic extract of Tinospora cordifolia roots on antioxidant defence in alloxan-induced diabetes in rats...
  8. Protective effect of a polyherbal formulation (Immu-21) against cyclophosphamide-induced mutagenicity in mice
    G B Jena
    Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Sector-67, S A S Nagar, Punjab 160 062, India
    Phytother Res 17:306-10
    ..Immu-21, which contains extracts of Ocimum sanctum, Withania somnifera, Emblica officinalis and Tinospora cordifolia, was given at 100 mg/kg, daily, over 7 days, and 30 mg/kg daily over 14 days and inhibited both CP-..
  9. Inhibitory effect of a polysaccharide from Tinospora cordifolia on experimental metastasis
    P V Leyon
    Department of Immunology, Amala Cancer Research Centre, Amala Nagar PO, Thrissur Dt, Kerala 680 553, India
    J Ethnopharmacol 90:233-7
    Administration of the polysaccharide fraction from Tinospora cordifolia was found to be very effective in reducing the metastatic potential of B16F-10 melanoma cells...
  10. Tinospora cordifolia as an adjuvant drug in the treatment of hyper-reactive malarious splenomegaly--case reports
    Ranjan Kumar Singh
    District Hospital, Daltonganj, Jharkhand, India
    J Vector Borne Dis 42:36-8
    BACKGROUND & OBJECTIVE: The effect of aqueous extract of Tinospora cordifolia, an immunomodulator with antimalarial activity along with chloroquine was studied in the treatment of three cases of hyper-reactive malarious splenomegaly ..
  11. Amelioration of experimental diabetic neuropathy and gastropathy in rats following oral administration of plant (Eugenia jambolana, Mucuna pruriens and Tinospora cordifolia) extracts
    J K Grover
    Department of Pharmacology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    Indian J Exp Biol 40:273-6
    ..M. charantia and E. jambolana modified it favorably while M. pruriens and T. cordifolia did not exert any favorable change...
  12. Immunoprotection by botanical drugs in cancer chemotherapy
    Sham Diwanay
    Department of Microbiology, Abasaheb Garware College, Pune, India
    J Ethnopharmacol 90:49-55
    ..prepared from medicinal plants mentioned in Ayurveda, namely, Withania somnifera (Linn Dunal) (Solanaceae), Tinospora cordifolia (Miers) (Menispermaceae), and Asparagus racemosus (Willd...
  13. Validation of therapeutic claims of Tinospora cordifolia: a review
    T S Panchabhai
    Ayurveda Research Center, Department of Pharmacology and Therapeutics, Seth GS Medical College and KEM Hospital, Mumbai, India
    Phytother Res 22:425-41
    This review article attempts to correlate Ayurvedic pharmacology and therapeutic claims for Tinospora cordifolia (Tc) with the evidence generated using scientific research methodology...
  14. Effect of Tinospora cordifolia on gamma ray-induced perturbations in macrophages and splenocytes
    Lakshman Singh
    Department of Radiation Biology, Institute of Nuclear Medicine and Allied Sciences, Delhi, India
    J Radiat Res (Tokyo) 48:305-15
    b>Tinospora cordifolia (RTc) has already been reported to protect whole-body lethally irradiated mice. This study has focussed on certain aspects of immuno-competence, which are adversely affected by irradiation...
  15. Evaluation of the antiosteoporotic potential of Tinospora cordifolia in female rats
    P Kapur
    Department of Biotechnology, Indian Institute of Technology Roorkee, Uttarakhand, India
    Maturitas 59:329-38
    ..OBJECTIVE: Present animal studies were conducted to investigate the potential of Tinospora cordifolia (TC) ethanolic stem extract as an antiosteoporotic agent...
  16. Study on cardiac contractility of cycloeucalenol and cycloeucalenone isolated from Tinospora crispa
    Ngampong Kongkathip
    Department of Chemistry, Faculty of Science, Kasetsart University, Bangkok, Thailand
    J Ethnopharmacol 83:95-9
    This report describes the isolation of two triterpenes from the stems of Tinospora crispa, namely, cycloeucalenol (1). and cycloeucalenone (2). for the first time. It was found that cycloeucalenol (1)...
  17. [Preparation of a syrup with Bakis roots (Tinospora bakis) and evaluation of its choleretic activity in rats]
    O Thioune
    Laboratoire de Pharmacie Galénique et Législation, Faculté de Médecine, de Pharmacie et d'Odonto Stomatoiogie, UCAD, Senegal
    Dakar Med 47:60-3
    ..Therefore, futher investigations in order to improve the quality of the sirup can be considered before performing clinical trials...
  18. [Antipyretic effect of aqueous extract and alcaloid of Tinospora bakis (Miers) in rabbits]
    L R Zafinindra
    Laboratoire de Pharmacognosie et Botanique, Faculté de Médecine, Pharmacie et d'Odonto-Stomatologie, Université Cheikh Anta Diop de Dakar, BP 5005, Sénégal
    Dakar Med 48:29-33
    Lyophilised aqueous extract and alcaloidic totum (basic form) from roots of Tinospora bakis (Miers) have been tested with hyperthermic rabbits by sub-cutaneous administration of Saccharomyces cerevisiae mixture at 2g/kg...
  19. Radioprotective potential of an herbal extract of Tinospora cordifolia
    Harish Chandra Goel
    Department of Radiation Biology, Institute of Nuclear Medicine and Allied Sciences, Delhi, India
    J Radiat Res (Tokyo) 45:61-8
    A preparation of Tinospora cordifolia (RTc) administered i.p. (200 mg/kg b.w...
  20. Immune stimulating properties of a novel polysaccharide from the medicinal plant Tinospora cordifolia
    P K Raveendran Nair
    Research Institute, Miami Children's Hospital, 3100 SW 62nd Avenue, Miami, FL 33155, USA
    Int Immunopharmacol 4:1645-59
    ..kDa and exhibiting unique immune stimulating properties is isolated and characterized from the medicinal plant Tinospora cordifolia...
  21. G1-4A, an immunomodulatory polysaccharide from Tinospora cordifolia, modulates macrophage responses and protects mice against lipopolysaccharide induced endotoxic shock
    Veena R Desai
    Radiation Biology and Health Sciences Division, Bio Medical Group, Mumbai 400 085, India
    Int Immunopharmacol 7:1375-86
    ..we have investigated the possibility of using an arabinogalactan polysaccharide, G1-4A, from the stem of Tinospora cordifolia, for protection against endotoxin induced sepsis...
  22. Chemopreventive potential of an Indian medicinal plant (Tinospora cordifolia) on skin carcinogenesis in mice
    Ranu Chaudhary
    Radiation and Cancer Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur 302 004, India
    J Environ Pathol Toxicol Oncol 27:233-43
    b>Tinospora cordifolia (Guduchi), an Indian medicinal plant, was used to explore antitumor promoting activity in a two-stage skin carcinogenesis model...
  23. Free radical scavenging and metal chelation by Tinospora cordifolia, a possible role in radioprotection
    H C Goel
    Department of Radiation Biology, Institute of Nuclear Medicine and Allied Sciences, Brig SK Majumdar Marg, Delhi 110 054
    Indian J Exp Biol 40:727-34
    ..The results reveal that the direct and indirect antioxidant actions of T. cordifolia probably act in corroboration to manifest the overall radioprotective effects...
  24. Antioxidant and radioprotective properties of an Ocimum sanctum polysaccharide
    Mahesh Subramanian
    Bio Organic Division, Bhabha Atomic Research Centre, Mumbai, India
    Redox Rep 10:257-64
    The antioxidant activity of two polysaccharides isolated from the Indian medicinal plants, Ocimum sanctum and Tinospora malabarica, was studied. Only the O. sanctum polysaccharide (OSP) showed significant activity...
  25. Evaluation of the antiretroviral activity of a new polyherbal drug (Immu-25) in patients with HIV infection
    P R Usha
    Department of Clinical Pharmacology and Therapeutics, Nizam s Institute of Medical Sciences, Hyderabad, India
    Drugs R D 4:103-9
    ..Further studies are warranted to confirm its therapeutic potential...
  26. Protective effect of Tinospora cordifolia, Phyllanthus emblica and their combination against antitubercular drugs induced hepatic damage: an experimental study
    T S Panchabhai
    Seth GS Medical College and KEM Hospital, Mumbai, India
    Phytother Res 22:646-50
    This study investigated the hepatoprotective effect of two Indian medicinal plants Tinospora cordifolia (Tc), Phyllanthus emblica (Pe), and their combination, in a rat model of isoniazid, rifampicin and pyrazinamide induced hepatic ..
  27. Tinospora cordifolia induces enzymes of carcinogen/drug metabolism and antioxidant system, and inhibits lipid peroxidation in mice
    R P Singh
    Cancer Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India
    Phytomedicine 13:74-84
    ..we investigated the effect of a hydroalcoholic (80% ethanol: 20% distilled water) extract of aerial roots of Tinospora cordifolia (50 and 100mg/kg body wt...
  28. Restoration of thymic homeostasis in a tumor-bearing host by in vivo administration of medicinal herb Tinospora cordifolia
    Nisha Singh
    School of Biotechnology, Banaras Hindu University, Varanasi, UP, India
    Immunopharmacol Immunotoxicol 27:585-99
    In vivo administration of alcoholic extract of medicinal plant Tinospora cordifolia (TC) to mice bearing a spontaneous T cell lymphoma designated as Dalton's lymphoma prevented tumor growth-dependent regression of thymus...
  29. Effect of alcoholic extract of Ayurvedic herb Tinospora cordifolia on the proliferation and myeloid differentiation of bone marrow precursor cells in a tumor-bearing host
    Sukh Mahendra Singh
    School of Biotechnology, Banaras Hindu University, Varanasi 221 005, India
    Fitoterapia 77:1-11
    The present study investigates the effect of in vivo administration of alcoholic extract of Tinospora cordifolia whole plant (ALTC) on the proliferation and myeloid differentiation of bone marrow hematopoietic precursor cells in mice ..
  30. Effect of Tinospora cordifolia on the cytokine profile of angiogenesis-induced animals
    P V Leyon
    Department Immunology, Amala Cancer Research Centre, Amalanagar, P.O. Thrissur, Kerala 680555, India
    Int Immunopharmacol 4:1569-75
    The antiangiogenic activity of Tinospora cordifolia was studied using in vivo as well as in vitro models. In vivo antiangiogenic activity was studied using B16F10 melanoma cell-induced capillary formation in animals...
  31. Antifertility effect of Tinospora cordifolia (Willd.) stem extract in male rats
    R S Gupta
    Reproduction Physiology Section, Department of Zoology, University of Rajasthan, Jaipur 302004, India
    Indian J Exp Biol 41:885-9
    ..Serum testosterone levels showed significant reduction after Tinospora extract feeding...
  32. Glycosyl composition of polysaccharide from Tinospora cordifolia
    Musliarakathbacker Jahfar
    Department of Chemistry, University of Calicut, Kerala, India 673 635
    Acta Pharm 53:65-9
    Polysaccharide from Tinospora cordifolia was isolated, purified, hydrolysed, trimethylsilylated and then subjected to GC-MC studies. The polysaccharide composition was estimated as follows: glucose 98.0%, arabinose 0.5%, rhamnose 0...
  33. New lignan glucosides from the stems of Tinospora sinensis
    Wei Li
    Faculty of Pharmaceutical Science, Toho University, Chiba, Japan
    Chem Pharm Bull (Tokyo) 52:638-40
    Two new lignan glucosides, tinosposides A and B (1 and 2), were isolated from the stems of Tinospora sinensis collected in Hainan Island, China. Their structures were elucidated on the basis of spectroscopic analysis and chemical evidence.
  34. Hepatocurative and antioxidant profile of HP-1, a polyherbal phytomedicine
    S A Tasaduq
    Biochemistry Lab, Division of Pharmacology, Regional Research Laboratory, Canal Road, Jammu-Tawi 180 001, India
    Hum Exp Toxicol 22:639-45
    ..of Phyllanthus niruri and extracts of Terminalia belerica, Terminalia chebula, Phyllanthus emblica and Tinospora cordifolia has been evaluated for hepatoprotective activity against carbon tetrachloride (CCl4) induced toxicity...
  35. Effect of Fagonia Arabica (Dhamasa) on in vitro thrombolysis
    Sweta Prasad
    Biochemistry Research Laboratory, Central India Institute of Medical Sciences, 88 2, Bajaj Nagar, Nagpur 440010, Maharashtra, India
    BMC Complement Altern Med 7:36
    ..b>Tinospora cordifolia, Rubia cordifolia, Hemidesmus indicus, Glycyrrhiza glabra Linn, Fagonia Arabica and Bacopa monnieri ..
  36. Quantitative LC/MS/MS method and pharmacokinetic studies of columbin, an anti-inflammation furanoditerpen isolated from Radix Tinosporae
    Qirong Shi
    Department of Natural Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, People s Republic of China
    Biomed Chromatogr 21:642-8
    ..v. and oral administration to rats. The oral bioavailability of columbin was only 3.18%, which indicated that columbin had poor absorption or underwent extensive first-pass metabolism...
  37. Effect of Tinospora cordifolia on the antitumor activity of tumor-associated macrophages-derived dendritic cells
    Nisha Singh
    School of Biotechnology, Banaras Hindu University, Varanasi, Uttar Pradesh, India
    Immunopharmacol Immunotoxicol 27:1-14
    We and others previously have reported that extract prepared from medicinal plant Tinospora cordifolia shows a wide spectrum of immunoaugmentary effects...
  38. Evaluation of the antineoplastic activity of guduchi (Tinospora cordifolia) in Ehrlich ascites carcinoma bearing mice
    Ganesh Chandra Jagetia
    Department of Radiobiology, Kasturba Medical College, Manipal, India
    Biol Pharm Bull 29:460-6
    The anticancer activity of dichloromethane extract of guduchi [Tinospora cordifolia (Willd.) Miers ex Hook. F. & Thoms. Family: Menispermaceae (TCE)] in the mice transplanted with Ehrlich ascites carcinoma (EAC) was investigated...
  39. Effect of Rubia cordifolia, Fagonia cretica linn, and Tinospora cordifolia on free radical generation and lipid peroxidation during oxygen-glucose deprivation in rat hippocampal slices
    Avinash Rawal
    SMV Center for Biotechnology, Sindhu Mahavidyalaya, Panchpaoli, Nagpur, MS 440017, India
    Biochem Biophys Res Commun 324:588-96
    ..Rubia cordifolia (RC), Fagonia cretica linn (FC), and Tinospora cordifolia (TC) have been reported to contain a wide variety of antioxidants and have been in use in the eastern ..
  40. Rubia cordifolia, Fagonia cretica linn and Tinospora cordifolia exert neuroprotection by modulating the antioxidant system in rat hippocampal slices subjected to oxygen glucose deprivation
    Avinash K Rawal
    SMV Center for Biotechnology, Sindhu Mahavidyalaya, Panchpaoli, Nagpur 440017, MS, India
    BMC Complement Altern Med 4:11
    ..Rubia cordifolia (RC), Fagonia cretica linn (FC) and Tinospora cordifolia (TC) have been reported to contain a wide variety of antioxidants and have been in use in the eastern ..
  41. Hepatoprotective and immunomodulatory properties of Tinospora cordifolia in CCl4 intoxicated mature albino rats
    Biswadev Bishayi
    Department of Physiology, Immunology Laboratory, University of Calcutta, 92, A.P.C. Road, Calcutta-700 009, India
    J Toxicol Sci 27:139-46
    Effect of Tinospora cordifolia extract on modulation of hepatoprotective and immunostimulatory functions in carbon tetrachloride (CCl4) intoxicated mature rats is reported here. Administration of CCl4 (0...
  42. Cardioprotective activity of alcoholic extract of Tinospora cordifolia in ischemia-reperfusion induced myocardial infarction in rats
    Pragada Rajeswara Rao
    Pharmacology Division, Department of Pharmaceutical Sciences, Andhra University, Pradesh, India
    Biol Pharm Bull 28:2319-22
    ..The present study was designed to investigate the effects of pretreatment with alcoholic extract of Tinospora cordifolia in an in vivo rat model...
  43. Immunostimulatory effect of Tinospora cordifolia Miers leaf extract in Oreochromis mossambicus
    D Samuel Sudhakaran
    Nagarjuna Fertilizers and Chemicals Limited, ICICI Knowledge Park, Hyderabad, India
    Indian J Exp Biol 44:726-32
    ..hydrophila. The results indicates the potential of T. cordifolia leaf extracts for use as an immunoprophylactic to prevent diseases in finfish aquaculture...
  44. Characterization of isoquinoline alkaloids, diterpenoids and steroids in the Chinese herb Jin-Guo-Lan (Tinospora sagittata and Tinospora capillipes) by high-performance liquid chromatography/electrospray ionization with multistage mass spectrometry
    Yufeng Zhang
    Pharmaceutical Informatics Institute, Zhejiang University, Hangzhou 310027, P.R. China
    Rapid Commun Mass Spectrom 20:2328-42
    ..diterpenoids and steroids) in crude extracts of the Chinese herb Jin-Guo-Lan, prepared from the roots of Tinospora sagittata and T...
  45. Main antimicrobial components of Tinospora capillipes, and their mode of action against Staphylococcus aureus
    Yan Yu
    Research Center of Modernization of Chinese Medicines, College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China
    FEBS Lett 581:4179-83
    ....
  46. Immunomodulatory and antitumor actions of medicinal plant Tinospora cordifolia are mediated through activation of tumor-associated macrophages
    Nisha Singh
    School of Biotechnology, Banaras Hindu University, Vanarasi, U.P, India
    Immunopharmacol Immunotoxicol 26:145-62
    ..DL), a spontaneous transplantable T cell lymphoma, can be activated by the alcoholic extract of medicinal plant Tinospora cordifolia (ALTC)...
  47. Structure and absolute configuration of clerodane diterpene glycosides and a rearranged cadinane sesquiterpene glycoside from the stems of Tinospora sinensis
    Wei Li
    Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba, Japan
    J Nat Prod 70:1971-6
    ..3), and a new rearranged cadinane sesquiterpene glycoside, tinosinenside ( 4), were isolated from the stems of Tinospora sinensis...
  48. Immunomodulatory role of Tinospora cordifolia as an adjuvant in surgical treatment of diabetic foot ulcers: a prospective randomized controlled study
    Harshad Purandare
    Department of Surgery, Seth G S Medical College and K E M Hospital, Mumbai, India
    Indian J Med Sci 61:347-55
    ..We evaluated the role of generalized immunomodulation in diabetic ulcers by using Tinospora cordifolia as an adjuvant therapy and studied its influence on parameters/determinants of healing, on bacterial ..
  49. Randomized controlled trial of Tinospora crispa for additional therapy in patients with type 2 diabetes mellitus
    Chawanya Sangsuwan
    Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    J Med Assoc Thai 87:543-6
    A randomized double blind placebo controlled trial was conducted to determine the efficacy of Tinospora crispa as additional treatment in patients with type 2 diabetes mellitus who did not respond to oral hypoglycemic drugs and refused ..
  50. [Malarial prophylaxis with medicinal plants: toxic hepatitis due to Tinospora crispa]
    Guillaume Denis
    Therapie 62:271-2
  51. Identification of Tinospora cordifolia (Willd.) Miers ex Hook F & Thomas using RAPD markers
    Gyana Ranjan Rout
    Plant Biotechnology Division, Regional Plant Resource Centre, Bhubaneswar 751015, Orissa, India
    Z Naturforsch C 61:118-22
    ..Studies were undertaken for identification and genetic variation within 15 clones of Tinospora cordifolia through random amplified polymorphic DNA (RAPD) markers...
  52. Amritosides A, B, C and D: clerodane furano diterpene glucosides from Tinospora cordifolia
    Rakesh Maurya
    Medicinal Chemistry Division, Central Drug Research Institute, Chattar Manzil Palace, MG Marg, Lucknow 226 001, India
    Phytochemistry 65:2051-5
    Four new clerodane furano diterpene glucosides (amritosides A, B, C and D) were isolated as their acetates from Tinospora cordifolia stems. The structures of these compounds were established on the basis of spectroscopic studies.
  53. Antioxidant properties of a Tinospora cordifolia polysaccharide against iron-mediated lipid damage and gamma-ray induced protein damage
    Mahesh Subramanian
    Bio-Organic Division, Bhabha Atomic Research Centre, Mumbai 400 085, India
    Redox Rep 7:137-43
    The antioxidant activity of an arabinogalactan polysaccharide (TSP) isolated from Tinospora cordifolia, an Indian medicinal plant, was studied...
  54. Prevention of hepatotoxicity due to anti tuberculosis treatment: a novel integrative approach
    Meghna R Adhvaryu
    Bapalal Vaidya Botanical Research Centre, Department of Biosciences, Veer Narmad South Gujarat University, 110, Nehru Nagar Society, Ichchhanath Road, Surat 395007, India
    World J Gastroenterol 14:4753-62
    AIM: To evaluate the ability of Curcuma longa (CL) and Tinospora cordifolia (TC) formulation to prevent anti-tuberculosis (TB) treatment (ATT) induced hepatotoxicity...
  55. Octacosanol isolated from Tinospora cordifolia downregulates VEGF gene expression by inhibiting nuclear translocation of NF-<kappa>B and its DNA binding activity
    G Thippeswamy
    Department of Studies in Applied Botany and Biotechnology, University of Mysore, Manasagangotri, Mysore 570006, India
    Eur J Pharmacol 588:141-50
    ..The present study identified octacosanol isolated from the plant Tinospora cordifolia as a new antiangiogenic compound with inhibitory effects on in vivo angiogenesis assays...
  56. Efficacy of Tinospora cordifolia in allergic rhinitis
    V A Badar
    Department of Pharmacology, Indira Gandhi Medical College, Nagpur 440018, India
    J Ethnopharmacol 96:445-9
    The efficacy of Tinospora cordifolia (TC) extract in patients of allergic rhinitis was assessed in a randomized double blind placebo controlled trial. Seventy-five patients were randomly given either TC or placebo for 8 weeks...
  57. Mechanism of macrophage activation by (1,4)-alpha-D-glucan isolated from Tinospora cordifolia
    P K Raveendran Nair
    Research Institute, Miami Children's Hospital, Miami, FL 33155, USA
    Int Immunopharmacol 6:1815-24
    The signaling mechanism of the novel (1,4)-alpha-D-glucan (RR1) isolated from the medicinal plant Tinospora cordifolia was investigated in macrophages to evaluate its immunostimulating properties. When RAW264...
  58. Glycosyl composition of polysaccharide from Tinospora cordifolia. II. Glycosyl linkages
    Musliarakathbacker Jahfar
    Department of Chemistry, University of Calicut, Kerala-673 635, India
    Acta Pharm 54:73-8
    Polysaccharide from Tinospora cordifolia was isolated, purified, methylated, hydrolyzed, reduced and acetylated. The partially methylated alditol acetate (PMAA) derivative thus obtained was subjected to GC-MS studies...
  59. Enhanced production of the polysaccharide arabinogalactan using immobilized cultures of Tinospora cordifolia by elicitation and in situ adsorption
    G Roja
    Nuclear Agriculture and Biotechnology Division, Bhabha Atomic Research Centre, Trombay, Mumbai 4000 85, India
    Biotechnol Prog 21:1688-91
    Immobilized callus cultures of Tinospora cordifolia (Willd) Miers ex Hooks and Thoms were investigated to find out the combined effect of elicitation, cell permeabilization with chitosan and in situ product recovery by polymeric neutral ..
  60. Quantitative determination of four constituents of Tinospora sps. by a reversed-phase HPLC-UV-DAD method. Broad-based studies revealing variation in content of four secondary metabolites in the plant from different eco-geographical regions of India
    S M Ahmed
    Regional Research Laboratory, Canal Road, Jammu-180001, India
    J Chromatogr Sci 44:504-9
    ..markers, such as 20beta-hydroxyecdysone, tinosporaside, cordioside, and columbin, present in three species of Tinospora viz, T. cordifolia, T. malabrica, and T. crispa...