oxidative stress

Summary

Summary: A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).

Top Publications

  1. Egnatchik R, Leamy A, Noguchi Y, Shiota M, YOUNG J. Palmitate-induced activation of mitochondrial metabolism promotes oxidative stress and apoptosis in H4IIEC3 rat hepatocytes. Metabolism. 2014;63:283-95 pubmed publisher
    ..Our results indicate that ROS accumulation in palmitate-treated H4IIEC3 cells occurs downstream of altered mitochondrial oxidative metabolism, which is independent of beta-oxidation and precedes apoptosis initiation. ..
  2. Shvedova A, Yanamala N, Murray A, Kisin E, Khaliullin T, Hatfield M, et al. Oxidative stress, inflammatory biomarkers, and toxicity in mouse lung and liver after inhalation exposure to 100% biodiesel or petroleum diesel emissions. J Toxicol Environ Health A. 2013;76:907-21 pubmed publisher
    ..Overall, the tissue damage, oxidative stress, inflammation, and cytokine response were more pronounced in mice exposed to BD CE...
  3. Li B, Cui W, Liu J, Li R, Liu Q, Xie X, et al. Sulforaphane ameliorates the development of experimental autoimmune encephalomyelitis by antagonizing oxidative stress and Th17-related inflammation in mice. Exp Neurol. 2013;250:239-49 pubmed publisher
    ..This study was aimed at investigating the effect of treatment with SFN on inflammation and oxidative stress, and the potential mechanisms underlying the action of SFN in experimental autoimmune encephalomyelitis (EAE) ..
  4. Sutti S, Jindal A, Locatelli I, Vacchiano M, Gigliotti L, Bozzola C, et al. Adaptive immune responses triggered by oxidative stress contribute to hepatic inflammation in NASH. Hepatology. 2014;59:886-97 pubmed publisher
    ..To substantiate the role of immune responses triggered by oxidative stress in the progression of NASH, mice were immunized with MDA-adducted bovine serum albumin (MDA-BSA) before ..
  5. Patel H, Chen J, Das K, Kavdia M. Hyperglycemia induces differential change in oxidative stress at gene expression and functional levels in HUVEC and HMVEC. Cardiovasc Diabetol. 2013;12:142 pubmed publisher
  6. Rodrigo R, Libuy M, Feliú F, Hasson D. Oxidative stress-related biomarkers in essential hypertension and ischemia-reperfusion myocardial damage. Dis Markers. 2013;35:773-90 pubmed publisher
    ..However, the validation of oxidative stress-related biomarkers in these settings is still lacking and novel association of these biomarkers and other ..
  7. Fu J, Fan H, Guo Z, Wang Z, Li X, Li J, et al. Salvianolic acid B attenuates spinal cord ischemia-reperfusion-induced neuronal injury and oxidative stress by activating the extracellular signal-regulated kinase pathway in rats. J Surg Res. 2014;188:222-30 pubmed publisher
    ..We investigated the effects of SalB treatment in a rat model of spinal cord ischemia and reperfusion (I/R) injury and the underlying mechanism...
  8. Greene M, Burrington C, Lynch D, Davenport S, Johnson A, Horsman M, et al. Lipid metabolism, oxidative stress and cell death are regulated by PKC delta in a dietary model of nonalcoholic steatohepatitis. PLoS ONE. 2014;9:e85848 pubmed publisher
    Steatosis, oxidative stress, and apoptosis underlie the development of nonalcoholic steatohepatitis (NASH)...
  9. Hollomon M, Gordon N, Santiago O Farrill J, Kleinerman E. Knockdown of autophagy-related protein 5, ATG5, decreases oxidative stress and has an opposing effect on camptothecin-induced cytotoxicity in osteosarcoma cells. BMC Cancer. 2013;13:500 pubmed publisher
    ..b>Oxidative stress was assessed by staining cells with HE and DCFH-DA followed by flow cytometry analysis...
  10. Than A, Zhang X, Leow M, Poh C, Chong S, Chen P. Apelin attenuates oxidative stress in human adipocytes. J Biol Chem. 2014;289:3763-74 pubmed publisher
    It has been recently recognized that the increased oxidative stress (ROS overproduction) in obese condition is a key contributor to the pathogenesis of obesity-associated metabolic diseases...

Detail Information

Publications62

  1. Egnatchik R, Leamy A, Noguchi Y, Shiota M, YOUNG J. Palmitate-induced activation of mitochondrial metabolism promotes oxidative stress and apoptosis in H4IIEC3 rat hepatocytes. Metabolism. 2014;63:283-95 pubmed publisher
    ..Our results indicate that ROS accumulation in palmitate-treated H4IIEC3 cells occurs downstream of altered mitochondrial oxidative metabolism, which is independent of beta-oxidation and precedes apoptosis initiation. ..
  2. Shvedova A, Yanamala N, Murray A, Kisin E, Khaliullin T, Hatfield M, et al. Oxidative stress, inflammatory biomarkers, and toxicity in mouse lung and liver after inhalation exposure to 100% biodiesel or petroleum diesel emissions. J Toxicol Environ Health A. 2013;76:907-21 pubmed publisher
    ..Overall, the tissue damage, oxidative stress, inflammation, and cytokine response were more pronounced in mice exposed to BD CE...
  3. Li B, Cui W, Liu J, Li R, Liu Q, Xie X, et al. Sulforaphane ameliorates the development of experimental autoimmune encephalomyelitis by antagonizing oxidative stress and Th17-related inflammation in mice. Exp Neurol. 2013;250:239-49 pubmed publisher
    ..This study was aimed at investigating the effect of treatment with SFN on inflammation and oxidative stress, and the potential mechanisms underlying the action of SFN in experimental autoimmune encephalomyelitis (EAE) ..
  4. Sutti S, Jindal A, Locatelli I, Vacchiano M, Gigliotti L, Bozzola C, et al. Adaptive immune responses triggered by oxidative stress contribute to hepatic inflammation in NASH. Hepatology. 2014;59:886-97 pubmed publisher
    ..To substantiate the role of immune responses triggered by oxidative stress in the progression of NASH, mice were immunized with MDA-adducted bovine serum albumin (MDA-BSA) before ..
  5. Patel H, Chen J, Das K, Kavdia M. Hyperglycemia induces differential change in oxidative stress at gene expression and functional levels in HUVEC and HMVEC. Cardiovasc Diabetol. 2013;12:142 pubmed publisher
  6. Rodrigo R, Libuy M, Feliú F, Hasson D. Oxidative stress-related biomarkers in essential hypertension and ischemia-reperfusion myocardial damage. Dis Markers. 2013;35:773-90 pubmed publisher
    ..However, the validation of oxidative stress-related biomarkers in these settings is still lacking and novel association of these biomarkers and other ..
  7. Fu J, Fan H, Guo Z, Wang Z, Li X, Li J, et al. Salvianolic acid B attenuates spinal cord ischemia-reperfusion-induced neuronal injury and oxidative stress by activating the extracellular signal-regulated kinase pathway in rats. J Surg Res. 2014;188:222-30 pubmed publisher
    ..We investigated the effects of SalB treatment in a rat model of spinal cord ischemia and reperfusion (I/R) injury and the underlying mechanism...
  8. Greene M, Burrington C, Lynch D, Davenport S, Johnson A, Horsman M, et al. Lipid metabolism, oxidative stress and cell death are regulated by PKC delta in a dietary model of nonalcoholic steatohepatitis. PLoS ONE. 2014;9:e85848 pubmed publisher
    Steatosis, oxidative stress, and apoptosis underlie the development of nonalcoholic steatohepatitis (NASH)...
  9. Hollomon M, Gordon N, Santiago O Farrill J, Kleinerman E. Knockdown of autophagy-related protein 5, ATG5, decreases oxidative stress and has an opposing effect on camptothecin-induced cytotoxicity in osteosarcoma cells. BMC Cancer. 2013;13:500 pubmed publisher
    ..b>Oxidative stress was assessed by staining cells with HE and DCFH-DA followed by flow cytometry analysis...
  10. Than A, Zhang X, Leow M, Poh C, Chong S, Chen P. Apelin attenuates oxidative stress in human adipocytes. J Biol Chem. 2014;289:3763-74 pubmed publisher
    It has been recently recognized that the increased oxidative stress (ROS overproduction) in obese condition is a key contributor to the pathogenesis of obesity-associated metabolic diseases...
  11. Maaroufi K, Had Aissouni L, Melon C, Sakly M, Abdelmelek H, Poucet B, et al. Spatial learning, monoamines and oxidative stress in rats exposed to 900 MHz electromagnetic field in combination with iron overload. Behav Brain Res. 2014;258:80-9 pubmed publisher
    ..Biogenic monoamines and metabolites (dopamine, serotonin) and oxidative stress were measured...
  12. Li J, O W, Li W, Jiang Z, Ghanbari H. Oxidative stress and neurodegenerative disorders. Int J Mol Sci. 2013;14:24438-75 pubmed publisher
    ..However, an excessive amount of ROS under oxidative stress would be extremely deleterious...
  13. Wakui H, Dejima T, Tamura K, Uneda K, Azuma K, Maeda A, et al. Activation of angiotensin II type 1 receptor-associated protein exerts an inhibitory effect on vascular hypertrophy and oxidative stress in angiotensin II-mediated hypertension. Cardiovasc Res. 2013;100:511-9 pubmed publisher
    ..In this study, we investigated the effects of ATRAP on Ang II-induced vascular remodelling...
  14. Zehendner C, Librizzi L, Hedrich J, Bauer N, Angamo E, de Curtis M, et al. Moderate hypoxia followed by reoxygenation results in blood-brain barrier breakdown via oxidative stress-dependent tight-junction protein disruption. PLoS ONE. 2013;8:e82823 pubmed publisher
    ..These findings suggest that the BBB is susceptible towards MHR and that ROS play a key role in this process. ..
  15. Doronzo G, Viretto M, Barale C, Russo I, Mattiello L, Anfossi G, et al. Oleic acid increases synthesis and secretion of VEGF in rat vascular smooth muscle cells: role of oxidative stress and impairment in obesity. Int J Mol Sci. 2013;14:18861-80 pubmed publisher
    ..the above mentioned signaling pathways and increases ROS; (c) OA-induced activation of PKC-beta enhances oxidative stress, which activates signaling pathways responsible for the increased VEGF synthesis/secretion...
  16. Li W, Xu H, Hu Y, He P, Ni Z, Xu H, et al. Edaravone protected human brain microvascular endothelial cells from methylglyoxal-induced injury by inhibiting AGEs/RAGE/oxidative stress. PLoS ONE. 2013;8:e76025 pubmed publisher
    ..seems to be implicated in the development of diabetic vascular complication due to its protein glycation and oxidative stress effect...
  17. Dhiman M, Wan X, Popov V, Vargas G, Garg N. MnSODtg mice control myocardial inflammatory and oxidative stress and remodeling responses elicited in chronic Chagas disease. J Am Heart Assoc. 2013;2:e000302 pubmed publisher
    ..scavenge mitochondrial and cellular reactive oxygen species to investigate the pathological significance of oxidative stress in Chagas disease...
  18. Hausding M, Jurk K, Daub S, Kröller Schön S, Stein J, Schwenk M, et al. CD40L contributes to angiotensin II-induced pro-thrombotic state, vascular inflammation, oxidative stress and endothelial dysfunction. Basic Res Cardiol. 2013;108:386 pubmed publisher
    ..by promoting platelet-leukocyte activation, vascular infiltration of immune cells and by amplifying oxidative stress. C57BL/6 and CD40L-/- mice were infused with ATII (1 mg/kg/day for 7 days) using osmotic minipumps...
  19. Tamilselvam K, Braidy N, Manivasagam T, Essa M, Prasad N, Karthikeyan S, et al. Neuroprotective effects of hesperidin, a plant flavanone, on rotenone-induced oxidative stress and apoptosis in a cellular model for Parkinson's disease. Oxid Med Cell Longev. 2013;2013:102741 pubmed publisher
    ..Our data suggests that hesperidin exerts its neuroprotective effect against rotenone due to its antioxidant, maintenance of mitochondrial function, and antiapoptotic properties in a neuroblastoma cell line. ..
  20. Cabrerizo S, De La Cruz J, Lopez Villodres J, Muñoz Marín J, Guerrero A, Reyes J, et al. Role of the inhibition of oxidative stress and inflammatory mediators in the neuroprotective effects of hydroxytyrosol in rat brain slices subjected to hypoxia reoxygenation. J Nutr Biochem. 2013;24:2152-7 pubmed publisher
    ..Maximum inhibition was 57.4% in vitro and 38.7% ex vivo. Hydroxytyrosol reduced oxidative stress parameters: it inhibited lipid peroxidation and increased enzymatic activities related with the glutathione ..
  21. Wiegman C, Li F, Clarke C, Jazrawi E, Kirkham P, Barnes P, et al. A comprehensive analysis of oxidative stress in the ozone-induced lung inflammation mouse model. Clin Sci (Lond). 2014;126:425-40 pubmed publisher
    ..In the present study, we investigated the acute and chronic effects of ozone exposure-induced oxidative stress-related inflammation mechanics in mouse lung...
  22. Ahamed M, Ali D, Alhadlaq H, Akhtar M. Nickel oxide nanoparticles exert cytotoxicity via oxidative stress and induce apoptotic response in human liver cells (HepG2). Chemosphere. 2013;93:2514-22 pubmed publisher
    ..Further, ROS scavenger vitamin C reduced cell death drastically caused by NiO NPs exposure indicating that oxidative stress plays an important role in NiO NPs toxicity...
  23. Kubicova L, Hadacek F, Chobot V. Quinolinic acid: neurotoxin or oxidative stress modulator?. Int J Mol Sci. 2013;14:21328-38 pubmed publisher
    ..Our results support the notion that redox chemistry can contribute to explaining the hormetic dose-response effects. ..
  24. Belcher J, Chen C, Nguyen J, Milbauer L, Abdulla F, Alayash A, et al. Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease. Blood. 2014;123:377-90 pubmed publisher
    ..We conclude that intravascular hemolysis in SCD releases heme that activates endothelial TLR4 signaling leading to WPB degranulation, NF-?B activation, and vaso-occlusion. ..
  25. Hegde S, Adhikari P, Shetty S, Manjrekar P, D Souza V. Effect of community-based yoga intervention on oxidative stress and glycemic parameters in prediabetes: a randomized controlled trial. Complement Ther Med. 2013;21:571-6 pubmed publisher
    To study the effectiveness of yoga intervention on oxidative stress, glycemic status, blood pressure and anthropometry in prediabetes. Randomized-controlled trial. Twenty nine prediabetes subjects aged 30-75 years...
  26. Mazière C, Salle V, Gomila C, Mazière J. Oxidized low density lipoprotein increases RANKL level in human vascular cells. Involvement of oxidative stress. Biochem Biophys Res Commun. 2013;440:295-9 pubmed publisher
    ..with H2O2 or with buthionine sulfoximine (BSO), an inhibitor of glutathione synthesis, also induced an oxidative stress and enhanced RANKL level...
  27. Castro M, Francini F, Gagliardino J, Massa M. Lipoic acid prevents fructose-induced changes in liver carbohydrate metabolism: role of oxidative stress. Biochim Biophys Acta. 2014;1840:1145-51 pubmed publisher
    Fructose administration rapidly induces oxidative stress that triggers compensatory hepatic metabolic changes...
  28. Villanueva I, Alva Sánchez C, Pacheco Rosado J. The role of thyroid hormones as inductors of oxidative stress and neurodegeneration. Oxid Med Cell Longev. 2013;2013:218145 pubmed publisher
    ..THs are related to oxidative stress not only by their stimulation of metabolism but also by their effects on antioxidant mechanisms...
  29. Morikawa D, Itoigawa Y, Nojiri H, Sano H, Itoi E, Saijo Y, et al. Contribution of oxidative stress to the degeneration of rotator cuff entheses. J Shoulder Elbow Surg. 2014;23:628-35 pubmed publisher
    ..In this study, we investigated the supraspinatus tendon enthesis to clarify the link between rotator cuff degeneration and oxidative stress in antioxidant enzyme superoxide dismutase 1 (Sod1)-deficient mice (Sod1(-/-)).
  30. Lian H, Gao Y, Jiao G, Sun M, Wu X, Wang T, et al. Antioxidant supplementation overcomes the deleterious effects of maternal restraint stress-induced oxidative stress on mouse oocytes. Reproduction. 2013;146:559-68 pubmed publisher
    ..we tested the hypothesis that restraint stress would impair the developmental potential of oocytes by causing oxidative stress and that antioxidant supplementation could overcome the adverse effect of stress-induced oxidative stress...
  31. Asemi Z, Samimi M, Heidarzadeh Z, Khorrammian H, Tabassi Z. A randomized controlled clinical trial investigating the effect of calcium supplement plus low-dose aspirin on hs-CRP, oxidative stress and insulin resistance in pregnant women at risk for pre-eclampsia. Pak J Biol Sci. 2012;15:469-76 pubmed
    Increased levels of pro-inflammatory factors, markers of oxidative stress and insulin resistance during pregnancy have been associated with the development of pre-eclampsia...
  32. Sies H. Role of metabolic H2O2 generation: redox signaling and oxidative stress. J Biol Chem. 2014;289:8735-41 pubmed publisher
    ..Metabolically generated H2O2 emerged from recent research as a central hub in redox signaling and oxidative stress. Upon generation by major sources, the NADPH oxidases or Complex III of the mitochondrial respiratory chain, ..
  33. Ikawa Yoshida A, Ando K, Oki E, Saeki H, Kumashiro R, Taketani K, et al. Contribution of BubR1 to oxidative stress-induced aneuploidy in p53-deficient cells. Cancer Med. 2013;2:447-56 pubmed publisher
    ..b>Oxidative stress (OS) causes DNA damage and chromosome instability that may lead to carcinogenesis...
  34. Bozkus F, San I, Ulas T, Iynen I, Yesilova Y, Guler Y, et al. Evaluation of total oxidative stress parameters in patients with nasal polyps. Acta Otorhinolaryngol Ital. 2013;33:248-53 pubmed
    b>Oxidative stress, an imbalance between reactive oxygen species production and antioxidative defense activity, is believed to have a role in the development and pathogenesis of nasal polyps (NPs)...
  35. Hole P, Zabkiewicz J, Munje C, Newton Z, Pearn L, White P, et al. Overproduction of NOX-derived ROS in AML promotes proliferation and is associated with defective oxidative stress signaling. Blood. 2013;122:3322-30 pubmed publisher
    ..to a lesser extent, normal CD34(+) cells, and that the response to ROS is limited by the activation of the oxidative stress pathway mediated though p38(MAPK)...
  36. Sha W, Martins A, Laubenbacher R, Mendes P, Shulaev V. The genome-wide early temporal response of Saccharomyces cerevisiae to oxidative stress induced by cumene hydroperoxide. PLoS ONE. 2013;8:e74939 pubmed publisher
    b>Oxidative stress is a well-known biological process that occurs in all respiring cells and is involved in pathophysiological processes such as aging and apoptosis...
  37. Sharma D, Sunkaria A, Wani W, Sharma R, Kandimalla R, Bal A, et al. Aluminium induced oxidative stress results in decreased mitochondrial biogenesis via modulation of PGC-1? expression. Toxicol Appl Pharmacol. 2013;273:365-80 pubmed publisher
    ..was carried out to elucidate a possible molecular mechanism related to the effects of aluminium-induced oxidative stress on various mitochondrial respiratory complex subunits with special emphasis on the role of Peroxisome ..
  38. Tie R, Ji L, Nan Y, Wang W, Liang X, Tian F, et al. Achyranthes bidentata polypeptides reduces oxidative stress and exerts protective effects against myocardial ischemic/reperfusion injury in rats. Int J Mol Sci. 2013;14:19792-804 pubmed publisher
    ..Our study demonstrated for the first time that ABPP reduces oxidative stress and exerts cardioprotection against MI/R injury in rats...
  39. Demir B, Ozyazgan S, Korkmaz G, Karakaya O, Aciksari G, Uygun T, et al. The relationship between ischemia modified albumin and oxidative stress parameters in patients with cardiac syndrome X. Clin Lab. 2013;59:1319-29 pubmed
    The objective of this study was to evaluate the serum levels of ischemia modified albumin and oxidative stress parameters in patients with cardiac syndrome X...
  40. Klein R, Myers C, Cruickshanks K, Gangnon R, Danforth L, Sivakumaran T, et al. Markers of inflammation, oxidative stress, and endothelial dysfunction and the 20-year cumulative incidence of early age-related macular degeneration: the Beaver Dam Eye Study. JAMA Ophthalmol. 2014;132:446-55 pubmed publisher
    ..OBJECTIVE To examine the relationships of markers of inflammation, oxidative stress, and endothelial dysfunction to the 20-year cumulative incidence of early AMD...
  41. Shichiri M, Harada N, Ishida N, Komaba L, Iwaki S, Hagihara Y, et al. Oxidative stress is involved in fatigue induced by overnight deskwork as assessed by increase in plasma tocopherylhydroqinone and hydroxycholesterol. Biol Psychol. 2013;94:527-33 pubmed publisher
    ..The ratio of 7?-OHCh to total cholesterol and the value of CFF showed a significant correlation. From these results, plasma levels of ?TQ and 7?-OHCh are useful and objective indicators of fatigue induced by overnight deskwork. ..
  42. Moutzouri E, Liberopoulos E, Tellis C, Milionis H, Tselepis A, Elisaf M. Comparison of the effect of simvastatin versus simvastatin/ezetimibe versus rosuvastatin on markers of inflammation and oxidative stress in subjects with hypercholesterolemia. Atherosclerosis. 2013;231:8-14 pubmed publisher
    ..or rosuvastatin at equivalent low-density lipoprotein cholesterol lowering doses on inflammation and oxidative stress indices in subjects with hypercholesterolemia...
  43. Takaki A, Kawai D, Yamamoto K. Multiple hits, including oxidative stress, as pathogenesis and treatment target in non-alcoholic steatohepatitis (NASH). Int J Mol Sci. 2013;14:20704-28 pubmed publisher
    ..Multiple hits induce adipokine secretion, endoplasmic reticulum (ER) and oxidative stress at the cellular level that subsequently induce hepatic steatosis, inflammation and fibrosis, among which ..
  44. Miyamoto N, Maki T, Pham L, Hayakawa K, Seo J, Mandeville E, et al. Oxidative stress interferes with white matter renewal after prolonged cerebral hypoperfusion in mice. Stroke. 2013;44:3516-21 pubmed publisher
    ..Here, we test the hypothesis that oxidative stress interferes with endogenous white matter repair by disrupting renewal processes mediated by oligodendrocyte ..
  45. Shah A, Kumar S, Simon S, Singh D, Kumar A. HIV gp120- and methamphetamine-mediated oxidative stress induces astrocyte apoptosis via cytochrome P450 2E1. Cell Death Dis. 2013;4:e850 pubmed publisher
    ..cause neurotoxicity via several mechanisms including production of proinflammatory cytokines/chemokines and oxidative stress. Likewise, drug abuse is thought to have a direct impact on the pathology of HIV-associated neuroinflammation ..
  46. Zhu X, Zhang Z, Li P, Liang W, Feng X, Liu M. Shenyuan, an extract of American Ginseng and Corydalis Tuber formula, attenuates cardiomyocyte apoptosis via inhibition of endoplasmic reticulum stress and oxidative stress in a porcine model of acute myocardial infarction. J Ethnopharmacol. 2013;150:672-81 pubmed publisher
  47. Modra H, Blahova J, Marsalek P, Banoch T, Fictum P, Svoboda M. The effects of mycotoxin deoxynivalenol (DON) on haematological and biochemical parameters and selected parameters of oxidative stress in piglets. Neuro Endocrinol Lett. 2013;34 Suppl 2:84-9 pubmed
    ..of this study was to determine the effect of DON in feed on haematological and biochemical parameters and on oxidative stress in piglets. Two concentrations of DON in feedstuff for pigs were chosen: 0.6?mg/kg (group C) and 2...
  48. Wang Y, Zhou L, Zhao Y, Wang S, Chen L, Liu L, et al. Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress. EMBO J. 2014;33:1304-20 pubmed publisher
    ..G6PD) is a key enzyme in the pentose phosphate pathway (PPP) and plays an essential role in the oxidative stress response by producing NADPH, the main intracellular reductant...
  49. Ciofani G, Genchi G, Mazzolai B, Mattoli V. Transcriptional profile of genes involved in oxidative stress and antioxidant defense in PC12 cells following treatment with cerium oxide nanoparticles. Biochim Biophys Acta. 2014;1840:495-506 pubmed publisher
    ..ROS) scavengers in many biological contexts, for instance offering neuroprotection and reduction of apoptosis rate in many types of cells exposed to oxidative stress (stem cells, endothelial cells, epithelial cells, osteoblasts, etc.).
  50. Rodrigues M, Stotzer U, Domingos M, Deminice R, Shiguemoto G, Tomaz L, et al. Effects of ovariectomy and resistance training on oxidative stress markers in the rat liver. Clinics (Sao Paulo). 2013;68:1247-54 pubmed publisher
    The objective of this study was to assess the effects of resistance training on oxidative stress markers in the livers of ovariectomized rats.
  51. Narayanan A, Amaya M, Voss K, Chung M, Benedict A, Sampey G, et al. Reactive oxygen species activate NF?B (p65) and p53 and induce apoptosis in RVFV infected liver cells. Virology. 2014;449:270-86 pubmed publisher
    ..Collectively, we identified ROS and oxidative stress as critical contributors to apoptosis of liver cells during RVFV infection.
  52. Ramyaa P, Krishnaswamy R, Padma V. Quercetin modulates OTA-induced oxidative stress and redox signalling in HepG2 cells - up regulation of Nrf2 expression and down regulation of NF-?B and COX-2. Biochim Biophys Acta. 2014;1840:681-92 pubmed publisher
    ..OTA toxicity is fairly well characterized where oxidative stress is believed to play a role, however, the sequence of molecular events after OTA-exposure, have not been ..
  53. Setyawati M, Tay C, Leong D. Effect of zinc oxide nanomaterials-induced oxidative stress on the p53 pathway. Biomaterials. 2013;34:10133-42 pubmed publisher
    ..that p53 may be implicated in playing a dual regulatory role to determine cell survivability in response to oxidative stress induced by ZnO NMs...
  54. Palipoch S. A review of oxidative stress in acute kidney injury: protective role of medicinal plants-derived antioxidants. Afr J Tradit Complement Altern Med. 2013;10:88-93 pubmed
    ..b>Oxidative stress (OS)-related AKI has demonstrated the increasing of reactive oxygen species (ROS) and reactive nitrogen ..
  55. Maier O, Fischer R, Agresti C, Pfizenmaier K. TNF receptor 2 protects oligodendrocyte progenitor cells against oxidative stress. Biochem Biophys Res Commun. 2013;440:336-41 pubmed publisher
    ..Interestingly, preconditioning with a TNFR2 agonist protects these cells from oxidative stress, presumably by increasing the gene expression of distinct anti-apoptotic and detoxifying proteins, thereby ..
  56. Bartoskova M, Dobsíková R, Stancova V, Zivna D, Blahova J, Marsalek P, et al. Evaluation of ibuprofen toxicity for zebrafish (Danio rerio) targeting on selected biomarkers of oxidative stress. Neuro Endocrinol Lett. 2013;34 Suppl 2:102-8 pubmed
    The aim of the study was to investigate the effects of subchronic exposure of zebrafish to ibuprofen, using selected oxidative stress parameters as a target.
  57. Zhao Y, Zhang L, Qiao Y, Zhou X, Wu G, Wang L, et al. Heme oxygenase-1 prevents cardiac dysfunction in streptozotocin-diabetic mice by reducing inflammation, oxidative stress, apoptosis and enhancing autophagy. PLoS ONE. 2013;8:e75927 pubmed publisher
    Heme oxygenase-1 (HO-1) has been implicated in cardiac dysfunction, oxidative stress, inflammation, apoptosis and autophagy associated with heart failure, and atherosclerosis, in addition to its recognized role in metabolic syndrome and ..
  58. Christopher K, Pedler M, Shieh B, Ammar D, Petrash J, Mueller N. Alpha-crystallin-mediated protection of lens cells against heat and oxidative stress-induced cell death. Biochim Biophys Acta. 2014;1843:309-15 pubmed publisher
    ..recombinant ?-crystallin proteins were examined for their ability to prevent cell death induced by heat or oxidative stress in a human lens epithelial cell line (HLE-B3)...
  59. Gibson C, Srivastava K, Sprigg N, Bath P, Bayraktutan U. Inhibition of Rho-kinase protects cerebral barrier from ischaemia-evoked injury through modulations of endothelial cell oxidative stress and tight junctions. J Neurochem. 2014;129:816-26 pubmed publisher
    ..post-ischaemia alone revealed these benefits to be independent of changes in the activity and expressions of oxidative stress- and tight junction-related parameters...
  60. Shen H, Liu J, Wang Y, Lian H, Wang J, Xing L, et al. Aflatoxin G1-induced oxidative stress causes DNA damage and triggers apoptosis through MAPK signaling pathway in A549 cells. Food Chem Toxicol. 2013;62:661-9 pubmed publisher
    ..DNA damage and apoptosis induced by oxidative stress are well accepted causes of cell damage...
  61. Pekovic Vaughan V, Gibbs J, Yoshitane H, Yang N, Pathiranage D, Guo B, et al. The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis. Genes Dev. 2014;28:548-60 pubmed publisher
    ..While the mechanism of NRF2 activation upon oxidative stress has been widely investigated, little is known about the endogenous signals that regulate the NRF2 pathway in ..
  62. Rowe W, Kershaw C, Castelli L, Costello J, Ashe M, Grant C, et al. Puf3p induces translational repression of genes linked to oxidative stress. Nucleic Acids Res. 2014;42:1026-41 pubmed publisher
    ..We find a strong association between transcripts acutely translationally repressed under oxidative stress and those associated with the RNA-binding protein Puf3p, a known regulator of cellular mRNAs encoding ..