Summary: The formation of LYMPHATIC VESSELS.

Top Publications

  1. Lahdenranta J, Hagendoorn J, Padera T, Hoshida T, Nelson G, Kashiwagi S, et al. Endothelial nitric oxide synthase mediates lymphangiogenesis and lymphatic metastasis. Cancer Res. 2009;69:2801-8 pubmed publisher
    ..These findings indicate that eNOS mediates VEGF-C-induced lymphangiogenesis and, consequently, plays a critical role in lymphatic metastasis...
  2. Albuquerque R, Hayashi T, Cho W, Kleinman M, Dridi S, Takeda A, et al. Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth. Nat Med. 2009;15:1023-30 pubmed publisher
    ..form of the protein, designated soluble Vegfr-2 (sVegfr-2), that inhibits developmental and reparative lymphangiogenesis by blocking Vegf-c function...
  3. Yu J, Henske E. mTOR activation, lymphangiogenesis, and estrogen-mediated cell survival: the "perfect storm" of pro-metastatic factors in LAM pathogenesis. Lymphat Res Biol. 2010;8:43-9 pubmed publisher
  4. Fang C, Miguel M, Avis I, Martinez A, Zudaire E, Cuttitta F. Non-peptide small molecule regulators of lymphangiogenesis. Lymphat Res Biol. 2009;7:189-96 pubmed publisher
    ..GRP) are neuroendocrine peptides that have been previously implicated as regulators of angiogenesis and lymphangiogenesis. Using an immortalized human dermal microvascular lymphatic endothelial cell line stably transfected with ..
  5. Li M, Chen H, Diao L, Zhang Y, Xia C, Yang F. Caveolin-1 and VEGF-C promote lymph node metastasis in the absence of intratumoral lymphangiogenesis in non-small cell lung cancer. Tumori. 2010;96:734-43 pubmed
    ..This study aimed to define the caveolin-1 and VEGF-C expression and lymph vessel density in NSCLC and look for correlations with clinicopathological features in NSCLC...
  6. Karadayi N, Kandemir N, Yavuzer D, Korkmaz T, Gecmen G, Kokturk F. Inducible nitric oxide synthase expression in gastric adenocarcinoma: impact on lymphangiogenesis and lymphatic metastasis. Diagn Pathol. 2013;8:151 pubmed publisher
    ..In this study, the possible link between inducible nitric oxide synthase (iNOS) expression with lymphangiogenesis and the clinicopathological parameters of gastric carcinomas was investigated.
  7. Kinashi H, Ito Y, Mizuno M, Suzuki Y, Terabayashi T, Nagura F, et al. TGF-?1 promotes lymphangiogenesis during peritoneal fibrosis. J Am Soc Nephrol. 2013;24:1627-42 pubmed publisher
    ..Lymphatic reabsorption also may contribute to UFF, but little is known about lymphangiogenesis in patients with UFF and peritonitis...
  8. Dębiński P, Dembowski J, Kowal P, Szydełko T, Kołodziej A, Małkiewicz B, et al. The clinical significance of lymphangiogenesis in renal cell carcinoma. Med Sci Monit. 2013;19:606-11 pubmed publisher
    The formation of lymphatic vessels (lymphangiogenesis) occurs in tumor tissues and is crucial for tumor development and progression in some cancers...
  9. Yao J, Da M, Guo T, Duan Y, Zhang Y. RNAi-mediated gene silencing of vascular endothelial growth factor-C inhibits tumor lymphangiogenesis and growth of gastric cancer in vivo in mice. Tumour Biol. 2013;34:1493-501 pubmed publisher
    ..VEGF-C) has been implicated as a critical molecular signal in tumor development by promoting intratumoral lymphangiogenesis. The aim of this study was to explore whether small hairpin RNA (shRNA) targeting VEGF-C could inhibit ..

More Information


  1. Lee E, Koskimaki J, Pandey N, Popel A. Inhibition of lymphangiogenesis and angiogenesis in breast tumor xenografts and lymph nodes by a peptide derived from transmembrane protein 45A. Neoplasia. 2013;15:112-24 pubmed
    ..b>Lymphangiogenesis also facilitates metastasis by increasing dissemination through the lymphatic vessels (LVs)...
  2. Hägerling R, Pollmann C, Andreas M, Schmidt C, Nurmi H, Adams R, et al. A novel multistep mechanism for initial lymphangiogenesis in mouse embryos based on ultramicroscopy. EMBO J. 2013;32:629-44 pubmed publisher
    ..Altogether, we present a significantly more detailed view and novel model of early lymphatic development. ..
  3. Shibata M, Ambati J, Shibata E, Yoshidome K, Harada Shiba M. Mammary cancer gene therapy targeting lymphangiogenesis: VEGF-C siRNA and soluble VEGF receptor-2, a splicing variant. Med Mol Morphol. 2012;45:179-84 pubmed publisher
    ..Overexpression of vascular endothelial growth factor (VEGF)-C has been associated with lymphangiogenesis and lymph node metastasis in a multitude of human neoplasms, including breast cancers...
  4. Bracher A, Cardona A, Tauber S, Fink A, Steiner A, Pehamberger H, et al. Epidermal growth factor facilitates melanoma lymph node metastasis by influencing tumor lymphangiogenesis. J Invest Dermatol. 2013;133:230-8 pubmed publisher EGF-high melanoma cells, EGFkd led to a significant reduction of lymph node metastasis and primary tumor lymphangiogenesis in vivo, as well as impairment of tumor cell migration in vitro...
  5. Liu Z, Qiu H, Yuan X, Ni Y, Sun J, Jing W, et al. Suppression of lymphangiogenesis in human lymphatic endothelial cells by simultaneously blocking VEGF-C and VEGF-D/VEGFR-3 with norcantharidin. Int J Oncol. 2012;41:1762-72 pubmed publisher
    Lymph node metastasis of tumors is a crucial early step in the metastatic process. Tumor lymphangiogenesis plays an important role in promoting tumor metastasis to regional lymph nodes...
  6. Lund A, Durães F, Hirosue S, Raghavan V, Nembrini C, Thomas S, et al. VEGF-C promotes immune tolerance in B16 melanomas and cross-presentation of tumor antigen by lymph node lymphatics. Cell Rep. 2012;1:191-9 pubmed publisher
    ..Our findings introduce a tumor-promoting role for lymphatics in the tumor and dLN and suggest that lymphatic endothelium in the local microenvironment may be a target for immunomodulation...
  7. Xin X, Majumder M, Girish G, Mohindra V, Maruyama T, Lala P. Targeting COX-2 and EP4 to control tumor growth, angiogenesis, lymphangiogenesis and metastasis to the lungs and lymph nodes in a breast cancer model. Lab Invest. 2012;92:1115-28 pubmed publisher
    ..cancer cell migration and invasiveness, production of vascular endothelial growth factor (VEGF)-C and lymphangiogenesis in situ, largely from endogenous PGE2-mediated stimulation of prostaglandin E (EP)1 and EP4 receptors, ..
  8. Wang W, Yang Z, Liu J, Jiang S, Miao X. Identification of CD146 expression, angiogenesis, and lymphangiogenesis as progression, metastasis, and poor-prognosis related markers for gallbladder adenocarcinoma. Tumour Biol. 2012;33:173-82 pubmed publisher
    ..Our study suggested that the elevated expression of CD146, angiogenesis, and lymphangiogenesis might be closely related to progression, invasion, metastasis, and prognosis of gallbladder adenocarcinoma.
  9. Yin N, Zhang N, Lal G, Xu J, Yan M, Ding Y, et al. Lymphangiogenesis is required for pancreatic islet inflammation and diabetes. PLoS ONE. 2011;6:e28023 pubmed publisher
    b>Lymphangiogenesis is a common phenomenon observed during inflammation and engraftment of transplants, but its precise role in the immune response and underlying mechanisms of regulation remain poorly defined...
  10. Lapinski P, Kwon S, Lubeck B, Wilkinson J, Srinivasan R, Sevick Muraca E, et al. RASA1 maintains the lymphatic vasculature in a quiescent functional state in mice. J Clin Invest. 2012;122:733-47 pubmed publisher
  11. Suzuki Y, Ito Y, Mizuno M, Kinashi H, Sawai A, Noda Y, et al. Transforming growth factor-? induces vascular endothelial growth factor-C expression leading to lymphangiogenesis in rat unilateral ureteral obstruction. Kidney Int. 2012;81:865-79 pubmed publisher
    Inflammation is recognized as an important contributor to lymphangiogenesis; however, in tubulointerstitial lesions in human chronic kidney diseases, this process is better correlated with the presence of myofibroblasts rather than ..
  12. Mendez U, Brown E, Ongstad E, Slis J, Goldman J. Functional recovery of fluid drainage precedes lymphangiogenesis in acute murine foreleg lymphedema. Am J Physiol Heart Circ Physiol. 2012;302:H2250-6 pubmed publisher
    ..Here, we compared the relative importance of lymphangiogenesis of lymphatic vessels and interstitial flows for restoring fluid drainage and resolving acute lymphedema in ..
  13. Abéngozar M, de Frutos S, Ferreiro S, Soriano J, Perez Martinez M, Olmeda D, et al. Blocking ephrinB2 with highly specific antibodies inhibits angiogenesis, lymphangiogenesis, and tumor growth. Blood. 2012;119:4565-76 pubmed publisher
  14. Nitta A, Shirasuna K, Haneda S, Matsui M, Shimizu T, Matsuyama S, et al. Possible involvement of IFNT in lymphangiogenesis in the corpus luteum during the maternal recognition period in the cow. Reproduction. 2011;142:879-92 pubmed publisher
    ..Interferon tau (IFNT) from the conceptus in the uterus is a candidate for activating luteal lymphangiogenesis during the maternal recognition period (MRP)...
  15. Buttler K, Badar M, Seiffart V, Laggies S, Gross G, Wilting J, et al. De novo hem- and lymphangiogenesis by endothelial progenitor and mesenchymal stem cells in immunocompetent mice. Cell Mol Life Sci. 2014;71:1513-27 pubmed publisher
    ..and suggest functions for VEGF-B, amphiregulin, fractalkine, CXCL10, and CXCL16 during MSC-induced hem- and lymphangiogenesis. We assume that lymphangiogenesis is induced indirectly by growth factors from immigrating leukocytes, which ..
  16. Schoppmann S, Jesch B, Zacherl J, Riegler M, Friedrich J, Birner P. Lymphangiogenesis and lymphovascular invasion diminishes prognosis in esophageal cancer. Surgery. 2013;153:526-34 pubmed publisher
    ..Behind the background of possible lymphangiogenesis-associated therapies, the clinical impact of lymphangiogenesis (measured by lymphatic microvessel density [..
  17. Zampell J, Yan A, Elhadad S, Avraham T, Weitman E, Mehrara B. CD4(+) cells regulate fibrosis and lymphangiogenesis in response to lymphatic fluid stasis. PLoS ONE. 2012;7:e49940 pubmed publisher
    ..The purpose of this study was therefore to characterize the inflammatory response to lymphatic stasis and determine if these responses are necessary for the pathological changes that occur in lymphedema...
  18. Gomes F, Nedel F, Alves A, NOR J, Tarquinio S. Tumor angiogenesis and lymphangiogenesis: tumor/endothelial crosstalk and cellular/microenvironmental signaling mechanisms. Life Sci. 2013;92:101-7 pubmed publisher
    Tumor angiogenesis and lymphangiogenesis are key features of tumor progression and metastasis...
  19. Miyata Y, Ohba K, Matsuo T, Watanabe S, Hayashi T, Sakai H, et al. Tumor-associated stromal cells expressing E-prostanoid 2 or 3 receptors in prostate cancer: correlation with tumor aggressiveness and outcome by angiogenesis and lymphangiogenesis. Urology. 2013;81:136-42 pubmed publisher
  20. Tabata T, Petitt M, Fang Hoover J, Rivera J, Nozawa N, Shiboski S, et al. Cytomegalovirus impairs cytotrophoblast-induced lymphangiogenesis and vascular remodeling in an in vivo human placentation model. Am J Pathol. 2012;181:1540-59 pubmed publisher
    ..that viral replication and paracrine factors could undermine vascular remodeling and cytotrophoblast-induced lymphangiogenesis, contributing to bleeding, hypoxia, and edema in pregnancies complicated by congenital human cytomegalovirus ..
  21. Zhao Y, Ni X, Wang M, Zha X, Zhao Y, Wang S. Tumor-derived VEGF-C, but not VEGF-D, promotes sentinel lymph node lymphangiogenesis prior to metastasis in breast cancer patients. Med Oncol. 2012;29:2594-600 pubmed publisher
    ..Recent studies have demonstrated that tumor cells induce SLN lymphangiogenesis before metastasis in several malignancies...
  22. Kim H, Kataru R, Koh G. Regulation and implications of inflammatory lymphangiogenesis. Trends Immunol. 2012;33:350-6 pubmed publisher
    ..Inflammation is a major cause of adulthood lymphangiogenesis and LV remodeling. In turn, LVs can reciprocally manipulate inflammatory processes...
  23. Zhao Y, Ni X, Li Y, Dai M, Yuan Z, Zhu Y, et al. Peritumoral lymphangiogenesis induced by vascular endothelial growth factor C and D promotes lymph node metastasis in breast cancer patients. World J Surg Oncol. 2012;10:165 pubmed publisher
    ..and experimental data suggest that the migration of tumor cells into lymph nodes is greatly facilitated by lymphangiogenesis. Vascular endothelial growth factor (VEGF)-C and D have been identified as lymphangiogenic growth factors ..