neurulation

Summary

Summary: An early embryonic developmental process of CHORDATES that is characterized by morphogenic movements of ECTODERM resulting in the formation of the NEURAL PLATE; the NEURAL CREST; and the NEURAL TUBE. Improper closure of the NEURAL GROOVE results in congenital NEURAL TUBE DEFECTS.

Top Publications

  1. Kimura Yoshida C, Mochida K, Ellwanger K, Niehrs C, Matsuo I. Fate Specification of Neural Plate Border by Canonical Wnt Signaling and Grhl3 is Crucial for Neural Tube Closure. EBioMedicine. 2015;2:513-27 pubmed publisher
    During primary neurulation, the separation of a single-layered ectodermal sheet into the surface ectoderm (SE) and neural tube specifies SE and neural ectoderm (NE) cell fates...
  2. Baumholtz A, Simard A, Nikolopoulou E, Oosenbrug M, Collins M, Piontek A, et al. Claudins are essential for cell shape changes and convergent extension movements during neural tube closure. Dev Biol. 2017;428:25-38 pubmed publisher
  3. Plouhinec J, Medina Ruiz S, Borday C, Bernard E, Vert J, Eisen M, et al. A molecular atlas of the developing ectoderm defines neural, neural crest, placode, and nonneural progenitor identity in vertebrates. PLoS Biol. 2017;15:e2004045 pubmed publisher
    During vertebrate neurulation, the embryonic ectoderm is patterned into lineage progenitors for neural plate, neural crest, placodes and epidermis...
  4. de Castro S, Hirst C, Savery D, Rolo A, Lickert H, Andersen B, et al. Neural tube closure depends on expression of Grainyhead-like 3 in multiple tissues. Dev Biol. 2018;435:130-137 pubmed publisher
    ..During spinal neurulation Grhl3 is initially expressed in the surface (non-neural) ectoderm, subsequently in the neuroepithelial ..