embryonic induction


Summary: The complex processes of initiating CELL DIFFERENTIATION in the embryo. The precise regulation by cell interactions leads to diversity of cell types and specific pattern of organization (EMBRYOGENESIS).

Top Publications

  1. Wei S, Xu G, Bridges L, Williams P, White J, DeSimone D. ADAM13 induces cranial neural crest by cleaving class B Ephrins and regulating Wnt signaling. Dev Cell. 2010;19:345-52 pubmed publisher
    ..We propose that by cleaving class B Efns, ADAM13 promotes canonical Wnt signaling and early CNC induction...
  2. Ladher R, Wright T, Moon A, Mansour S, Schoenwolf G. FGF8 initiates inner ear induction in chick and mouse. Genes Dev. 2005;19:603-13 pubmed
    ..Thus, Fgf8 plays a critical upstream role in an FGF signaling cascade required for otic induction in chick and mouse. ..
  3. Streit A. The preplacodal region: an ectodermal domain with multipotential progenitors that contribute to sense organs and cranial sensory ganglia. Int J Dev Biol. 2007;51:447-61 pubmed
    ..Here I review the molecular mechanisms that sequentially subdivide the ectoderm to give rise to the placode territory...
  4. Piepenburg O, Grimmer D, Williams P, Smith J. Activin redux: specification of mesodermal pattern in Xenopus by graded concentrations of endogenous activin B. Development. 2004;131:4977-86 pubmed
    ..It also emphasises the importance of checking for polymorphisms in the 5' untranslated region of the gene of interest when carrying out antisense morpholino experiments in Xenopus laevis. ..
  5. Huang X, Saint Jeannet J. Induction of the neural crest and the opportunities of life on the edge. Dev Biol. 2004;275:1-11 pubmed
    ..We also summarize some of these findings and discuss how the differential activation of these genes may contribute to the establishment of neural crest diversity. ..
  6. Steventon B, Carmona Fontaine C, Mayor R. Genetic network during neural crest induction: from cell specification to cell survival. Semin Cell Dev Biol. 2005;16:647-54 pubmed
    ..We will propose the division of this complex network of factors in two main steps: an initial cell specification step followed by a maintenance or cell survival step. ..
  7. Cornell R, Eisen J. Notch in the pathway: the roles of Notch signaling in neural crest development. Semin Cell Dev Biol. 2005;16:663-72 pubmed
    ..We raise the possibility that a single molecular mechanism, inhibition of so-called proneural bHLH genes, underlies both modes of lateral inhibition mediated by Notch signaling. ..
  8. Sauka Spengler T, Bronner Fraser M. A gene regulatory network orchestrates neural crest formation. Nat Rev Mol Cell Biol. 2008;9:557-68 pubmed publisher
    ..Here, we review our current understanding of these processes and discuss the molecular players that are involved in the neural crest gene regulatory network. ..
  9. Norton W, Mangoli M, Lele Z, Pogoda H, Diamond B, Mercurio S, et al. Monorail/Foxa2 regulates floorplate differentiation and specification of oligodendrocytes, serotonergic raphé neurones and cranial motoneurones. Development. 2005;132:645-58 pubmed

More Information


  1. Levine A, Brivanlou A. Proposal of a model of mammalian neural induction. Dev Biol. 2007;308:247-56 pubmed
    ..This model is very similar to the default model of neural induction in the frog, thus bridging the evolutionary gap between amphibians and mammals...
  2. Linker C, Stern C. Neural induction requires BMP inhibition only as a late step, and involves signals other than FGF and Wnt antagonists. Development. 2004;131:5671-81 pubmed
    ..We propose that neural induction involves additional signalling events that remain to be identified. ..
  3. Ang S, Constam D. A gene network establishing polarity in the early mouse embryo. Semin Cell Dev Biol. 2004;15:555-61 pubmed
    ..This likely results in an activity gradient which is instrumental to pattern the embryo proper. ..
  4. Shi J, Severson C, Yang J, Wedlich D, Klymkowsky M. Snail2 controls mesodermal BMP/Wnt induction of neural crest. Development. 2011;138:3135-45 pubmed publisher
    ..Taken together, these results identify Snail2 as a key regulator of the signals involved in mesodermal induction of neural crest...
  5. Kuroda H, Fuentealba L, Ikeda A, Reversade B, De Robertis E. Default neural induction: neuralization of dissociated Xenopus cells is mediated by Ras/MAPK activation. Genes Dev. 2005;19:1022-7 pubmed
    ..It is this activation of Ras/MAPK that is required for neuralization in dissociated ectoderm. ..
  6. Rodriguez T, Srinivas S, Clements M, Smith J, Beddington R. Induction and migration of the anterior visceral endoderm is regulated by the extra-embryonic ectoderm. Development. 2005;132:2513-20 pubmed
    ..Together, these data reveal a novel role for the ExE in the specification of the anteroposterior axis of the mouse embryo. ..
  7. Wawersik S, Evola C, Whitman M. Conditional BMP inhibition in Xenopus reveals stage-specific roles for BMPs in neural and neural crest induction. Dev Biol. 2005;277:425-42 pubmed
    ..Thus, BMP inhibition during gastrulation is insufficient for neural induction in intact embryos, arguing against a BMP gradient as the sole determinant of ectodermal cell fate in the frog. ..
  8. Patthey C, Gunhaga L, Edlund T. Early development of the central and peripheral nervous systems is coordinated by Wnt and BMP signals. PLoS ONE. 2008;3:e1625 pubmed publisher
  9. Nostro M, Cheng X, Keller G, Gadue P. Wnt, activin, and BMP signaling regulate distinct stages in the developmental pathway from embryonic stem cells to blood. Cell Stem Cell. 2008;2:60-71 pubmed publisher
    ..These findings highlight dynamic changes in signaling requirements during blood cell development and identify a role for Wnt signaling in the establishment of the primitive erythroid lineage. ..
  10. Li W, Cornell R. Redundant activities of Tfap2a and Tfap2c are required for neural crest induction and development of other non-neural ectoderm derivatives in zebrafish embryos. Dev Biol. 2007;304:338-54 pubmed
  11. Streit A. Early development of the cranial sensory nervous system: from a common field to individual placodes. Dev Biol. 2004;276:1-15 pubmed
  12. Ragland J, Raible D. Signals derived from the underlying mesoderm are dispensable for zebrafish neural crest induction. Dev Biol. 2004;276:16-30 pubmed
  13. Albazerchi A, Cinquin O, Stern C. A new method to transfect the hypoblast of the chick embryo reveals conservation of the regulation of an Otx2 enhancer between mouse and chick extraembryonic endoderm. BMC Dev Biol. 2007;7:25 pubmed
    ..Our findings also reveal that regulatory elements that direct gene expression to the mouse AVE are active in chick hypoblast, supporting the idea that these two tissues have homologous functions. ..
  14. Takebayashi Suzuki K, Arita N, Murasaki E, Suzuki A. The Xenopus POU class V transcription factor XOct-25 inhibits ectodermal competence to respond to bone morphogenetic protein-mediated embryonic induction. Mech Dev. 2007;124:840-55 pubmed
    ..results document an essential role for XOct-25 in commitment to neural or epidermal cell fates in the ectoderm and highlight the importance of a regulatory mechanism that limits competence to respond to BMP-mediated embryonic induction.
  15. Otto A, Schmidt C, Patel K. Pax3 and Pax7 expression and regulation in the avian embryo. Anat Embryol (Berl). 2006;211:293-310 pubmed
    ..Finally, we show that Wnt6 can mimic the effect of the dorsal ectoderm to maintain Pax3 and Pax7 expression. ..
  16. Bonano M, Tr bulo C, De Calisto J, Marchant L, S nchez S, Mayor R, et al. A new role for the Endothelin-1/Endothelin-A receptor signaling during early neural crest specification. Dev Biol. 2008;323:114-29 pubmed publisher
    ..Together, our results provide insight on a new role of Edn1/Ednra cell signaling pathway during early neural crest development...
  17. Taneyhill L, Bronner Fraser M. Dynamic alterations in gene expression after Wnt-mediated induction of avian neural crest. Mol Biol Cell. 2005;16:5283-93 pubmed
    ..Our results are the first to quantitatively describe changes in gene expression in response to a Wnt or BMP signal during transformation of a neural tube cell into a migratory neural crest cell. ..
  18. Donner A, Lachke S, Maas R. Lens induction in vertebrates: variations on a conserved theme of signaling events. Semin Cell Dev Biol. 2006;17:676-85 pubmed
    ..Finally, this review identifies future challenges in forming an integrated network of signaling pathways involved in lens induction. ..
  19. Albazerchi A, Stern C. A role for the hypoblast (AVE) in the initiation of neural induction, independent of its ability to position the primitive streak. Dev Biol. 2007;301:489-503 pubmed
    ..Interestingly, FGF and retinoids, generally considered as caudalizing factors, are shown here to play a role in the induction of a transient "pre-neural/pre-forebrain" state...
  20. Fang D, Leishear K, Nguyen T, Finko R, Cai K, Fukunaga M, et al. Defining the conditions for the generation of melanocytes from human embryonic stem cells. Stem Cells. 2006;24:1668-77 pubmed
    ..In summary, we have shown for the first time the differentiation of hESCs into melanocytes. This method provides a novel in vitro system for studying the development biology of human melanocytes. ..
  21. Capo Chichi C, Rula M, Smedberg J, Vanderveer L, Parmacek M, Morrisey E, et al. Perception of differentiation cues by GATA factors in primitive endoderm lineage determination of mouse embryonic stem cells. Dev Biol. 2005;286:574-86 pubmed
    ..This study indicates that the lineage differentiation of ES cells can be manipulated by the expression of GATA factors. ..
  22. Gunhaga L. The lens: a classical model of embryonic induction providing new insights into cell determination in early development. Philos Trans R Soc Lond B Biol Sci. 2011;366:1193-203 pubmed publisher
    The lens was the first tissue in which the concept of embryonic induction was demonstrated. For many years lens induction was thought to occur at the time the optic vesicle and lens placode came in contact...
  23. Pieper M, Ahrens K, Rink E, Peter A, Schlosser G. Differential distribution of competence for panplacodal and neural crest induction to non-neural and neural ectoderm. Development. 2012;139:1175-87 pubmed publisher
  24. Stern C. Neural induction: old problem, new findings, yet more questions. Development. 2005;132:2007-21 pubmed
    ..This review summarizes neural induction events in different species and highlights some unanswered questions about this important developmental process. ..
  25. Park C, Ma Y, Choi K. Evidence for the hemangioblast. Exp Hematol. 2005;33:965-70 pubmed
  26. Monsoro Burq A, Wang E, Harland R. Msx1 and Pax3 cooperate to mediate FGF8 and WNT signals during Xenopus neural crest induction. Dev Cell. 2005;8:167-78 pubmed
    ..Thus, WNT and FGF8 signals act in parallel at the neural border and converge on Pax3 activity during neural crest induction. ..
  27. Linker C, de Almeida I, Papanayotou C, Stower M, Sabado V, Ghorani E, et al. Cell communication with the neural plate is required for induction of neural markers by BMP inhibition: evidence for homeogenetic induction and implications for Xenopus animal cap and chick explant assays. Dev Biol. 2009;327:478-86 pubmed publisher
    ..We propose that the animal cap assay in Xenopus and explant assays in the chick are unsuitable for studying instructive signals in neural induction. ..
  28. Sheng G, dos Reis M, Stern C. Churchill, a zinc finger transcriptional activator, regulates the transition between gastrulation and neurulation. Cell. 2003;115:603-13 pubmed
    ..These results reveal that neural induction requires cessation of mesoderm formation at the midline in addition to the decision between epidermis and neural plate. ..
  29. Bertrand V, Hudson C, Caillol D, Popovici C, Lemaire P. Neural tissue in ascidian embryos is induced by FGF9/16/20, acting via a combination of maternal GATA and Ets transcription factors. Cell. 2003;115:615-27 pubmed
    ..Thus, our study identifies an endogenous FGF neural inducer and its early downstream gene cascade. It also reveals a role for GATA factors in FGF signaling. ..
  30. Bastidas F, De Calisto J, Mayor R. Identification of neural crest competence territory: role of Wnt signaling. Dev Dyn. 2004;229:109-17 pubmed
    ..Developmental Dynamics 229:109-117, 2004. ..
  31. Niehrs C. Regionally specific induction by the Spemann-Mangold organizer. Nat Rev Genet. 2004;5:425-34 pubmed
  32. Tam P, Kanai Azuma M, Kanai Y. Early endoderm development in vertebrates: lineage differentiation and morphogenetic function. Curr Opin Genet Dev. 2003;13:393-400 pubmed
    ..Morphogenetic interactions between the endoderm and the other germ layer derivatives are critical for the morphogenesis of head structures and organogenesis of gut derivatives. ..
  33. Holzschuh J, Barrallo Gimeno A, Ettl A, Durr K, Knapik E, Driever W. Noradrenergic neurons in the zebrafish hindbrain are induced by retinoic acid and require tfap2a for expression of the neurotransmitter phenotype. Development. 2003;130:5741-54 pubmed
    ..Thus, although the inductive signals may be distinct, hindbrain NA neurons of the locus coeruleus and the posterior groups both require Tfap2a to establish their noradrenergic identity. ..
  34. Pera E, Ikeda A, Eivers E, De Robertis E. Integration of IGF, FGF, and anti-BMP signals via Smad1 phosphorylation in neural induction. Genes Dev. 2003;17:3023-8 pubmed
    ..This hard-wired molecular mechanism at the level of the Smad1 transcription factor may help explain the opposing activities of IGF, FGF, and BMP signals not only in neural induction, but also in other aspects of vertebrate development. ..
  35. Duboc V, Röttinger E, Besnardeau L, Lepage T. Nodal and BMP2/4 signaling organizes the oral-aboral axis of the sea urchin embryo. Dev Cell. 2004;6:397-410 pubmed
    ..These observations suggest that the mechanisms responsible for patterning the oral-aboral axis of the sea urchin embryo may share similarities with mechanisms that pattern the dorsoventral axis of other deuterostomes. ..
  36. Inoue T, Hatayama M, Tohmonda T, Itohara S, Aruga J, Mikoshiba K. Mouse Zic5 deficiency results in neural tube defects and hypoplasia of cephalic neural crest derivatives. Dev Biol. 2004;270:146-62 pubmed
    ..Based on both their similar expression pattern in mouse embryos and the malformations observed in Zic5-deficient mutant mice, human ZIC5 might be involved in the deletion syndrome. ..
  37. Chapman S, Schubert F, Schoenwolf G, Lumsden A. Anterior identity is established in chick epiblast by hypoblast and anterior definitive endoderm. Development. 2003;130:5091-101 pubmed
    ..Based on this new evidence we propose a revised model for establishing anteroposterior polarity, neural specification and head patterning in the early chick that is consonant with that occurring in other vertebrates. ..
  38. Lewis J, Bonner J, Modrell M, Ragland J, Moon R, Dorsky R, et al. Reiterated Wnt signaling during zebrafish neural crest development. Development. 2004;131:1299-308 pubmed
    ..Taken together, these results demonstrate that Wnt signals are critical for the initial induction of zebrafish neural crest and suggest that this signaling pathway plays reiterated roles in its development. ..
  39. Glavic A, Silva F, Aybar M, Bastidas F, Mayor R. Interplay between Notch signaling and the homeoprotein Xiro1 is required for neural crest induction in Xenopus embryos. Development. 2004;131:347-59 pubmed
    ..These data also highlight the different roles played by BMP in neural crest specification in chick and Xenopus or zebrafish embryos. ..
  40. Nakamoto A, Arai A, Shimizu T. Specification of polarity of teloblastogenesis in the oligochaete annelid Tubifex: cellular basis for bilateral symmetry in the ectoderm. Dev Biol. 2004;272:248-61 pubmed
    ..Possible sources of signals for this polarizing induction are discussed in the light of the present results. ..
  41. Watanabe Y, Kokubo H, Miyagawa Tomita S, Endo M, Igarashi K, Aisaki K, et al. Activation of Notch1 signaling in cardiogenic mesoderm induces abnormal heart morphogenesis in mouse. Development. 2006;133:1625-34 pubmed
    ..Our present study thus indicates that the Notch1 signaling pathway plays a suppressive role both in AV myocardial differentiation and the maturation of the ventricular myocardium. ..
  42. Blaess S, Corrales J, Joyner A. Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region. Development. 2006;133:1799-809 pubmed
    ..Thus, the precise spatial and temporal regulation of Gli2A and Gli3R by Shh is instrumental in coordinating mid/hindbrain development in three dimensions. ..
  43. Sonntag K, Simantov R, Björklund L, Cooper O, Pruszak J, Kowalke F, et al. Context-dependent neuronal differentiation and germ layer induction of Smad4-/- and Cripto-/- embryonic stem cells. Mol Cell Neurosci. 2005;28:417-29 pubmed
    ..This demonstrates that Smad4-/- and Cripto-/- ES cells favor a neural fate in vitro, but also express the mesodermal phenotype, implying that deletion of either Smad4 or Cripto is not sufficient to block nonneuronal tissue formation. ..
  44. Cardoso W, LU J. Regulation of early lung morphogenesis: questions, facts and controversies. Development. 2006;133:1611-24 pubmed
    ..Here, we review early stages in lung development and highlight questions and controversies regarding their molecular regulation. ..
  45. Naruse M, Nakahira E, Miyata T, Hitoshi S, Ikenaka K, Bansal R. Induction of oligodendrocyte progenitors in dorsal forebrain by intraventricular microinjection of FGF-2. Dev Biol. 2006;297:262-73 pubmed
    ..These results demonstrate that the dorsal embryonic forebrain in vivo has the potential to generate OLPs in the presence of normal positional cues and that this can be driven by FGF-2 independent of Shh signaling. ..
  46. Shindo A, Yamamoto T, Ueno N. Coordination of cell polarity during Xenopus gastrulation. PLoS ONE. 2008;3:e1600 pubmed publisher
    ..These suggest that definitive tissue separation established by the distinct levels of nodal signaling is essential for the chordamesodermal cells to acquire mediolateral cell polarity. ..
  47. Sinha S, Wamhoff B, Hoofnagle M, Thomas J, Neppl R, Deering T, et al. Assessment of contractility of purified smooth muscle cells derived from embryonic stem cells. Stem Cells. 2006;24:1678-88 pubmed
  48. Kawaguchi Y, Takaori K, Uemoto S. Genetic lineage tracing, a powerful tool to investigate the embryonic organogenesis and adult organ maintenance of the pancreas. J Hepatobiliary Pancreat Sci. 2011;18:1-5 pubmed publisher
  49. Pan Y, Carbe C, Powers A, Zhang E, Esko J, Grobe K, et al. Bud specific N-sulfation of heparan sulfate regulates Shp2-dependent FGF signaling during lacrimal gland induction. Development. 2008;135:301-10 pubmed
    ..Given the evolutionarily conserved roles of these genes, the localized activation of the Ndst-Fgfr-Shp2 genetic cascade is probably a general regulatory mechanism of FGF signaling in branching morphogenesis. ..
  50. Rahman M, Glatz R, Roush R, Schmidt O. Developmental penalties associated with inducible tolerance in Helicoverpa armigera to insecticidal toxins from Bacillus thuringiensis. Appl Environ Microbiol. 2011;77:1443-8 pubmed publisher
    ..larval gut (larval induction) differs from the elevated immune status transmitted by epigenetic mechanisms (embryonic induction)...
  51. Phillips H, Murdoch J, Chaudhry B, Copp A, Henderson D. Vangl2 acts via RhoA signaling to regulate polarized cell movements during development of the proximal outflow tract. Circ Res. 2005;96:292-9 pubmed
  52. Nishimoto S, Nishida E. Fibroblast growth factor 13 is essential for neural differentiation in Xenopus early embryonic development. J Biol Chem. 2007;282:24255-61 pubmed
    ..Together, these results identify a role of FGF13 in Xenopus neural differentiation. ..
  53. Placzek M, Briscoe J. The floor plate: multiple cells, multiple signals. Nat Rev Neurosci. 2005;6:230-40 pubmed