maternal nutritional physiological phenomena


Summary: Nutrition of a mother which affects the health of the FETUS and INFANT as well as herself.

Top Publications

  1. Edwards C. Determinants and Duration of Impact of Early Gut Bacterial Colonization. Ann Nutr Metab. 2017;70:246-250 pubmed publisher
    ..The nutrition and health status of the mother before, during, and after birth may be major factors in the early colonization of the infant. ..
  2. Veena S, Krishnaveni G, Srinivasan K, Thajna K, Hegde B, Gale C, et al. Association between maternal vitamin D status during pregnancy and offspring cognitive function during childhood and adolescence. Asia Pac J Clin Nutr. 2017;26:438-449 pubmed publisher
    ..In this population, despite a high prevalence of vitamin D deficiency during pregnancy, there was no evidence of an association between maternal vitamin D status and offspring cognitive function. ..
  3. Vargas V, Gurung S, Grant B, Hyatt K, Singleton K, Myers S, et al. Gestational hypoxia disrupts the neonatal leptin surge and programs hyperphagia and obesity in male offspring in the Sprague-Dawley rat. PLoS ONE. 2017;12:e0185272 pubmed publisher
    ..HPX offspring had fewer ?MSH fibers in the PVN vs. NMX offspring on PN16. In conclusion, gestational hypoxia impacts the developing ARH resulting in hyperphagia contributing to adult obesity on a control diet and exacerbated by a HFD. ..
  4. Menon P. The crisis of poor complementary feeding in South Asia: where next?. Matern Child Nutr. 2012;8 Suppl 1:1-4 pubmed publisher
  5. McGuire S. World Health Organization. Comprehensive Implementation Plan on Maternal, Infant, and Young Child Nutrition. Geneva, Switzerland, 2014. Adv Nutr. 2015;6:134-5 pubmed publisher
  6. Stein A. Nutrition in early life and cognitive functioning. Am J Clin Nutr. 2014;99:1-2 pubmed publisher
  7. de Velasco P, Chicaybam G, Ramos Filho D, Dos Santos R, Mairink C, Sardinha F, et al. Maternal intake of trans-unsaturated or interesterified fatty acids during pregnancy and lactation modifies mitochondrial bioenergetics in the liver of adult offspring in mice. Br J Nutr. 2017;118:41-52 pubmed publisher
    ..In conclusion, maternal consumption of trans-unsaturated and interesterified fat affected offspring health by compromising mitochondrial bioenergetics and lipid metabolism in the liver. ..
  8. Nikiema L, Huybregts L, Martin Prevel Y, Donnen P, Lanou H, Grosemans J, et al. Effectiveness of facility-based personalized maternal nutrition counseling in improving child growth and morbidity up to 18 months: A cluster-randomized controlled trial in rural Burkina Faso. PLoS ONE. 2017;12:e0177839 pubmed publisher
    ..Complementary strategies are warranted to obtain meaningful impact on child growth and morbidity. This includes strategies to ensure good coverage of facility-based services and effective nutrition/care practices in early childhood. ..
  9. Pauwels S, Ghosh M, Duca R, Bekaert B, Freson K, Huybrechts I, et al. Maternal intake of methyl-group donors affects DNA methylation of metabolic genes in infants. Clin Epigenetics. 2017;9:16 pubmed publisher

More Information


  1. Steenweg de Graaff J, Roza S, Walstra A, El Marroun H, Steegers E, Jaddoe V, et al. Associations of maternal folic acid supplementation and folate concentrations during pregnancy with foetal and child head growth: the Generation R Study. Eur J Nutr. 2017;56:65-75 pubmed publisher
    ..More research is needed to identify whether specific brain regions are affected and whether effects of folate on foetal head growth influence children's long-term functioning. ..
  2. van Ansem W, Schrijvers C, Rodenburg G, van de Mheen D. Maternal educational level and children's healthy eating behaviour: role of the home food environment (cross-sectional results from the INPACT study). Int J Behav Nutr Phys Act. 2014;11:113 pubmed publisher
    ..Factors in the home food environment play an important role in the explanation of socio-economic disparities in children's healthy eating behaviour and may be promising targets for interventions. ..
  3. Williams A, Suchdev P. Assessing and Improving Childhood Nutrition and Growth Globally. Pediatr Clin North Am. 2017;64:755-768 pubmed publisher
    ..In this review, we address nutritional assessment, discuss nonnutritive factors that affect growth, and endorse the evidence-based interventions that should be scaled up to improve maternal and child nutrition. ..
  4. Black R, Alderman H, Bhutta Z, Gillespie S, Haddad L, Horton S, et al. Maternal and child nutrition: building momentum for impact. Lancet. 2013;382:372-375 pubmed publisher
  5. Eggemoen Å, Jenum A, Mdala I, Knutsen K, Lagerløv P, Sletner L. Vitamin D levels during pregnancy and associations with birth weight and body composition of the newborn: a longitudinal multiethnic population-based study. Br J Nutr. 2017;117:985-993 pubmed publisher
  6. Chou H, Kao C, Gau M. [Application of Epigenetics in Perinatal Nursing Care]. Hu Li Za Zhi. 2017;64:5-11 pubmed publisher
  7. Alheiros Lira M, Jurema Santos G, da Silva H, da Silva A, Moreno Senna S, Ferreira E Silva W, et al. Effects of high-fat diet on somatic growth, metabolic parameters and function of peritoneal macrophages of young rats submitted to a maternal low-protein diet. Br J Nutr. 2017;117:796-803 pubmed publisher
    ..Our data demonstrated that there was an immunomodulation related to dietary fatty acids after the maternal LP diet-induced metabolic programming. ..
  8. Zeng Z, Liu F, Li S. Metabolic Adaptations in Pregnancy: A Review. Ann Nutr Metab. 2017;70:59-65 pubmed publisher
    ..This review article concludes that metabolic adaptations are crucial for proper fetus development. ..
  9. Upadhyaya B, Larsen T, Barwari S, Louwagie E, Baack M, Dey M. Prenatal Exposure to a Maternal High-Fat Diet Affects Histone Modification of Cardiometabolic Genes in Newborn Rats. Nutrients. 2017;9: pubmed publisher
    ..These results indicate that maternal HF-diet changes the cardiac histone signature in offspring suggesting a fuel-mediated epigenetic reprogramming of cardiac tissue in utero. ..
  10. Ahmed F, Tseng M. Diet and nutritional status during pregnancy. Public Health Nutr. 2013;16:1337-9 pubmed publisher
  11. Williams J, Carrothers J, Lackey K, Beatty N, York M, Brooker S, et al. Human Milk Microbial Community Structure Is Relatively Stable and Related to Variations in Macronutrient and Micronutrient Intakes in Healthy Lactating Women. J Nutr. 2017;147:1739-1748 pubmed publisher
    ..Future studies designed to investigate the relation between maternal nutrient intake and the milk microbiome should strive to also evaluate dietary supplement usage and analyze the collected milk for its nutrient content. ..
  12. Wu M, Yang F. [Research advances in the association between maternal intake of methyl donor nutrients during pregnancy and DNA methylation in offspring]. Zhongguo Dang Dai Er Ke Za Zhi. 2017;19:601-606 pubmed
  13. Fox M, Martorell R, van den Broek N, Walker N. Assumptions and methods in the Lives Saved Tool (LiST). Introduction. BMC Public Health. 2011;11 Suppl 3:I1 pubmed publisher
  14. Stanford K, Takahashi H, So K, Alves Wagner A, Prince N, Lehnig A, et al. Maternal Exercise Improves Glucose Tolerance in Female Offspring. Diabetes. 2017;66:2124-2136 pubmed publisher
    ..The ability of maternal exercise to improve the metabolic health of female offspring is important, as this intervention could combat the transmission of obesity and diabetes to subsequent generations. ..
  15. Devi S, Mukhopadhyay A, Dwarkanath P, Thomas T, Crasta J, Thomas A, et al. Combined Vitamin B-12 and Balanced Protein-Energy Supplementation Affect Homocysteine Remethylation in the Methionine Cycle in Pregnant South Indian Women of Low Vitamin B-12 Status. J Nutr. 2017;147:1094-1103 pubmed publisher
    ..This trial was registered at as CTRI/2016/01/006578. ..
  16. Fainberg H, Almond K, Li D, Rauch C, Bikker P, Symonds M, et al. Impact of maternal dietary fat supplementation during gestation upon skeletal muscle in neonatal pigs. BMC Physiol. 2014;14:6 pubmed publisher
  17. Lumey L, Stein A. Transgenerational effects of prenatal exposure to the Dutch famine. BJOG. 2009;116:868; author reply 868 pubmed
  18. Billah S, Ferdous T, Karim M, Dibley M, Raihana S, Moinuddin M, et al. A community-based cluster randomised controlled trial to evaluate the effectiveness of different bundles of nutrition-specific interventions in improving mean length-for-age z score among children at 24 months of age in rural Bangladesh: study protoc. BMC Public Health. 2017;17:375 pubmed publisher
    ..Our study also will have policy-level implications for prioritising intervention(s) tackling stunting. The study was retrospectively registered on May 2, 2016 and is available online at (ID: NCT02768181 ). ..
  19. Wankhade U, Zhong Y, Kang P, Alfaro M, Chintapalli S, Thakali K, et al. Enhanced offspring predisposition to steatohepatitis with maternal high-fat diet is associated with epigenetic and microbiome alterations. PLoS ONE. 2017;12:e0175675 pubmed publisher
    ..Our findings indicate that maternal HFD detrimentally alters epigenetic and gut microbiome pathways to favor development of fatty liver disease and its progressive sequelae. ..
  20. Val Laillet D, Besson M, Guerin S, Coquery N, Randuineau G, Kanzari A, et al. A maternal Western diet during gestation and lactation modifies offspring's microbiota activity, blood lipid levels, cognitive responses, and hippocampal neurogenesis in Yucatan pigs. FASEB J. 2017;31:2037-2049 pubmed publisher
    ..Blat, S., Le Huërou-Luron, I., Clouard, C. A maternal Western diet during gestation and lactation modifies offspring's microbiota activity, blood lipid levels, cognitive responses, and hippocampal neurogenesis in Yucatan pigs. ..
  21. Odle J, Jacobi S, Boyd R, Bauman D, Anthony R, Bazer F, et al. The Potential Impact of Animal Science Research on Global Maternal and Child Nutrition and Health: A Landscape Review. Adv Nutr. 2017;8:362-381 pubmed publisher
    ..Better appreciation of the close linkage between human health, medicine, and agriculture will identify opportunities that will enable faster and more efficient innovations in global maternal and child health. ..
  22. Romero R, Erez O, Huttemann M, Maymon E, Panaitescu B, Conde Agudelo A, et al. Metformin, the aspirin of the 21st century: its role in gestational diabetes mellitus, prevention of preeclampsia and cancer, and the promotion of longevity. Am J Obstet Gynecol. 2017;217:282-302 pubmed publisher
    ..Herein, we discuss the mechanisms of action and potential benefits of metformin. ..
  23. Mridha M, Matias S, Paul R, Hussain S, Sarker M, Hossain M, et al. Prenatal Lipid-Based Nutrient Supplements Do Not Affect Pregnancy or Childbirth Complications or Cesarean Delivery in Bangladesh: A Cluster-Randomized Controlled Effectiveness Trial. J Nutr. 2017;147:1776-1784 pubmed publisher
    ..This trial was registered at as NCT01715038. ..
  24. Godfrey K, Costello P, Lillycrop K. Development, Epigenetics and Metabolic Programming. Nestle Nutr Inst Workshop Ser. 2016;85:71-80 pubmed publisher
    ..Elucidation of such epigenetic processes may enable early intervention strategies to improve early development and growth. ..
  25. Teh L, Pirkle C, Furgal C, Fillion M, Lucas M. Psychometric validation of the household food insecurity access scale among Inuit pregnant women from Northern Quebec. PLoS ONE. 2017;12:e0178708 pubmed publisher
    ..This is an efficient instrument that can inform interventions targeting health conditions impacting groups that obtain food through both monetary and non-monetary means. ..
  26. Maric Bilkan C, Symonds M, Ozanne S, Alexander B. Impact of maternal obesity and diabetes on long-term health of the offspring. Exp Diabetes Res. 2011;2011:163438 pubmed publisher
  27. Vohr B, Poggi Davis E, Wanke C, Krebs N. Neurodevelopment: The Impact of Nutrition and Inflammation During Preconception and Pregnancy in Low-Resource Settings. Pediatrics. 2017;139:S38-S49 pubmed publisher
  28. Sen S, Penfield Cyr A, Hollis B, Wagner C. Maternal Obesity, 25-Hydroxy Vitamin D Concentration, and Bone Density in Breastfeeding Dyads. J Pediatr. 2017;187:147-152.e1 pubmed publisher
    ..001; 95% CI -0.002, -0.0001). In exclusively breastfeeding dyads, maternal obesity is associated with lower maternal and infant serum 25(OH)D concentrations, which may impact infant bone density. NCT00412074. ..
  29. Power M, Uphoff E, Kelly B, Pickett K. Food insecurity and mental health: an analysis of routine primary care data of pregnant women in the Born in Bradford cohort. J Epidemiol Community Health. 2017;71:324-328 pubmed publisher
    ..These findings provide evidence for concerns expressed by public health experts that food insecurity may become the next public health emergency. ..
  30. West C. Developing a support service for overweight women. Pract Midwife. 2010;13:19-21 pubmed
  31. Miyaso H, Sakurai K, Takase S, Eguchi A, Watanabe M, Fukuoka H, et al. The methylation levels of the H19 differentially methylated region in human umbilical cords reflect newborn parameters and changes by maternal environmental factors during early pregnancy. Environ Res. 2017;157:1-8 pubmed publisher
    ..917; 95% CI: 0.838-0.990; p=0.040). These data indicated that H19-DMR methylation levels in human UC tissues could be modulated by maternal factors during early pregnancy and may affect fetal and newborn growth. ..
  32. Loo E, Ong L, Goh A, Chia A, Teoh O, Colega M, et al. Effect of Maternal Dietary Patterns during Pregnancy on Self-Reported Allergic Diseases in the First 3 Years of Life: Results from the GUSTO Study. Int Arch Allergy Immunol. 2017;173:105-113 pubmed publisher
    ..Maternal diet during pregnancy can influence the subsequent development of allergic outcomes in offspring. ..
  33. Nguyen P, Sanghvi T, Kim S, Tran L, Afsana K, Mahmud Z, et al. Factors influencing maternal nutrition practices in a large scale maternal, newborn and child health program in Bangladesh. PLoS ONE. 2017;12:e0179873 pubmed publisher
  34. Peccei A, Blake Lamb T, Rahilly D, Hatoum I, Bryant A. Intensive Prenatal Nutrition Counseling in a Community Health Setting: A Randomized Controlled Trial. Obstet Gynecol. 2017;130:423-432 pubmed publisher, NCT01056406. ..
  35. Darling A, Rayman M, Steer C, Golding J, Lanham New S, Bath S. Association between maternal vitamin D status in pregnancy and neurodevelopmental outcomes in childhood: results from the Avon Longitudinal Study of Parents and Children (ALSPAC). Br J Nutr. 2017;117:1682-1692 pubmed publisher
    ..Prevention of vitamin D deficiency may be important for preventing suboptimal development in the first 4 years of life. ..
  36. McGovern F, Sweeney T, Ryan M, Lott S, Campion F, Boland T. An investigation into the effects of maternal supplementation with excess iodine on the mechanisms and impacts of reduced IgG absorption in the lamb postpartum. Br J Nutr. 2017;117:951-963 pubmed publisher
    ..These effects were followed by an enhancement of average daily gain and lower N. battus FEC in the pre-weaning period of I-supplemented lambs. ..
  37. Traber M. Vitamin E inadequacy in humans: causes and consequences. Adv Nutr. 2014;5:503-14 pubmed
    ..This review evaluated the information available on the adverse consequences of inadequate ?-tocopherol status and provides suggestions for avenues for research. ..
  38. Charlton M. Fetal obesity syndrome: maternal nutrition as a cause of nonalcoholic steatohepatitis. Hepatology. 2009;50:1696-8 pubmed publisher
  39. Johnson W, Elmrayed S, Sosseh F, Prentice A, Moore S. Preconceptional and gestational weight trajectories and risk of delivering a small-for-gestational-age baby in rural Gambia. Am J Clin Nutr. 2017;105:1474-1482 pubmed publisher
    ..Independent of this possibility, greater second- and third-trimester weight gain beyond a threshold may be protective. This trial was registered at as ISRCTN49285450. ..
  40. Lee S, Pearce E. Reproductive endocrinology: Iodine intake in pregnancy--even a little excess is too much. Nat Rev Endocrinol. 2015;11:260-1 pubmed publisher
  41. Cuthbert C, Foster J, Ramdath D. A maternal high-fat, high-sucrose diet alters insulin sensitivity and expression of insulin signalling and lipid metabolism genes and proteins in male rat offspring: effect of folic acid supplementation. Br J Nutr. 2017;118:580-588 pubmed publisher
    ..Maternal HFS diet alters offspring insulin sensitivity and de novo hepatic lipogenesis via altered gene and protein expression, which appears to be potentiated by folate supplementation...
  42. Mårild K, Tapia G, Haugen M, Dahl S, Cohen A, Lundqvist M, et al. Maternal and neonatal vitamin D status, genotype and childhood celiac disease. PLoS ONE. 2017;12:e0179080 pubmed publisher
    ..Adjustment for established genetic risk markers for celiac disease gave similar results. We found no support for the hypothesis that maternal or neonatal vitamin D status is related to the risk of childhood celiac disease. ..
  43. Kim H, Kim H, Lee E, Kim Y, Ha E, Chang N. Association between maternal intake of n-6 to n-3 fatty acid ratio during pregnancy and infant neurodevelopment at 6 months of age: results of the MOCEH cohort study. Nutr J. 2017;16:23 pubmed publisher
    ..Thus, maintaining low n-6/n-3 PUFAs and LA/ALA is encouraged for women during pregnancy. ..
  44. Mridha M, Matias S, Paul R, Hussain S, Khan M, Siddiqui Z, et al. Daily Consumption of Lipid-Based Nutrient Supplements Containing 250 ?g Iodine Does Not Increase Urinary Iodine Concentrations in Pregnant and Postpartum Women in Bangladesh. J Nutr. 2017;147:1586-1592 pubmed publisher
    ..This trial was registered at as NCT01715038. ..
  45. Ma W, Lu J, Jiang S, Cai D, Pan S, Jia Y, et al. Maternal protein restriction depresses the duodenal expression of iron transporters and serum iron level in male weaning piglets. Br J Nutr. 2017;117:923-929 pubmed publisher
  46. Skreden M, Bere E, Sagedal L, Vistad I, Øverby N. Changes in fruit and vegetable consumption habits from pre-pregnancy to early pregnancy among Norwegian women. BMC Pregnancy Childbirth. 2017;17:107 pubmed publisher database, NCT01001689 . . ..
  47. Bø K, Artal R, Barakat R, Brown W, Davies G, Dooley M, et al. Exercise and pregnancy in recreational and elite athletes: 2016 evidence summary from the IOC expert group meeting, Lausanne. Part 1-exercise in women planning pregnancy and those who are pregnant. Br J Sports Med. 2016;50:571-89 pubmed publisher
  48. Cordero P, Milagro F, Campion J, Martinez J. Supplementation with methyl donors during lactation to high-fat-sucrose-fed dams protects offspring against liver fat accumulation when consuming an obesogenic diet. J Dev Orig Health Dis. 2014;5:385-95 pubmed publisher
    ..Interestingly, dietary methyl donor supplementation in lactating mothers fed an obesogenic diet reduced liver fat accumulation, but increased adipose tissue storage in adult HFS-fed offspring. ..
  49. Borja J. The impact of early nutrition on health: key findings from the Cebu Longitudinal Health and Nutrition Survey (CLHNS). Malays J Nutr. 2013;19:1-8 pubmed
    ..Since child nutrition begins in utero, programs should focus on improving maternal nutrition during pregnancy to minimise the risk of low birth weight. ..
  50. Bianchi C, de Gennaro G, Romano M, Battini L, Aragona M, Corfini M, et al. Italian national guidelines for the screening of gestational diabetes: Time for a critical appraisal?. Nutr Metab Cardiovasc Dis. 2017;27:717-722 pubmed publisher
    ..Finally, our finding of a 22% prevalence of GDM among low risk women suggests the need to consider additional risk factors, such as excessive weight gain during pregnancy. ..
  51. Seki Y, Suzuki M, Guo X, Glenn A, Vuguin P, Fiallo A, et al. In Utero Exposure to a High-Fat Diet Programs Hepatic Hypermethylation and Gene Dysregulation and Development of Metabolic Syndrome in Male Mice. Endocrinology. 2017;158:2860-2872 pubmed publisher
  52. Giussani D. The vulnerable developing brain. Proc Natl Acad Sci U S A. 2011;108:2641-2 pubmed publisher
  53. Prentice A, Jarjou L, Goldberg G, Bennett J, Cole T, Schoenmakers I. Maternal plasma 25-hydroxyvitamin D concentration and birthweight, growth and bone mineral accretion of Gambian infants. Acta Paediatr. 2009;98:1360-2 pubmed publisher