Summary: Research that involves the application of the natural sciences, especially biology and physiology, to medicine. (from American Heritage Dictionary, 4th ed)
Publications288 found, 100 shown here
- Central challenges facing the national clinical research enterpriseNancy S Sung
Burroughs Wellcome Fund, PO Box 13901, 21 T W Alexander Dr, Research Triangle Park, NC 27709, USA
JAMA 289:1278-87. 2003....
- The Connectivity Map: a new tool for biomedical researchJustin Lamb
Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA
Nat Rev Cancer 7:54-60. 2007The ultimate objective of biomedical research is to connect human diseases with the genes that underlie them and drugs that treat them...
- Relations in biomedical ontologiesBarry Smith
Institute for Formal Ontology and Medical Information Science, Saarland University, D 66041 Saarbrucken, Germany
Genome Biol 6:R46. 2005..The resulting Relation Ontology can promote interoperability of ontologies and support new types of automated reasoning about the spatial and temporal dimensions of biological and medical phenomena...
- Sex bias in neuroscience and biomedical researchAnnaliese K Beery
Robert Wood Johnson Health and Society Scholar at University of California, San Francisco, CA, USA
Neurosci Biobehav Rev 35:565-72. 2011Female mammals have long been neglected in biomedical research. The NIH mandated enrollment of women in human clinical trials in 1993, but no similar initiatives exist to foster research on female animals...
- Enhancing search efficiency by means of a search filter for finding all studies on animal experimentation in PubMedCarlijn R Hooijmans
Radboud University Nijmegen Medical Centre, Central Animal Laboratory and 3R Research Centre, Geert Grooteplein Noord 29, route 231, Nijmegen, The Netherlands
Lab Anim 44:170-5. 2010....
- Sharing detailed research data is associated with increased citation rateHeather A Piwowar
Department of Biomedical Informatics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
PLoS ONE 2:e308. 2007..Sharing research data provides benefit to the general scientific community, but the benefit is less obvious for the investigator who makes his or her data available...
- Guidance for developers of health research reporting guidelinesDavid Moher
Ottawa Methods Centre, Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
PLoS Med 7:e1000217. 2010..David Moher and colleagues from the EQUATOR network offer guidance and recommended steps for developing health research reporting guidelines...
- Contemporary low back pain research - and implications for practiceGlenn Pransky
Center for Disability Research, Liberty Mutual Research Institute for Safety, University of Massachusetts Medical Center, 71 Frankland Rd, Hopkinton, MA 01748, USA
Best Pract Res Clin Rheumatol 24:291-8. 2010..In this article, we review new perspectives and research studies that show promise, and suggest alternatives to current clinical and research paradigms...
- Prioritizing research: Patients, carers, and clinicians working together to identify and prioritize important clinical uncertainties in urinary incontinenceBrian S Buckley
Department of General Practice, National University of Ireland, Galway, Ireland
Neurourol Urodyn 29:708-14. 2010..This partnership of patients and clinicians aimed to identify and prioritize "clinical uncertainties" relating to treatment of urinary incontinence (UI)...
- Evaluating the informatics for integrating biology and the bedside system for clinical researchVikrant G Deshmukh
Department of Biomedical Informatics, University of Utah, Salt Lake City, UT 84112, USA
BMC Med Res Methodol 9:70. 2009..We describe the evaluation of a free and open source cohort selection tool from the Informatics for Integrating Biology and the Bedside (i2b2) group: the i2b2 hive...
- Mitochondrial proteomics and its application in biomedical researchCristina Ruiz-Romero
Laboratorio de Investigación Osteoarticular y del Envejecimiento, Unidad de Proteómica Nodo Asociado a ProteoRed, INIBIC Complejo Hospitalario Universitario A Coruña, 15006 A Coruna, Spain
Mol Biosyst 5:1130-42. 2009..This review will focus on the state-of-art proteomic strategies in mitochondrial research, and their application to biomedicine...
- A common layer of interoperability for biomedical ontologies based on OWL ELRobert Hoehndorf
Department of Genetics, University of Cambridge, Cambridge, UK
Bioinformatics 27:1001-8. 2011Ontologies are essential in biomedical research due to their ability to semantically integrate content from different scientific databases and resources...
- The South London and Maudsley NHS Foundation Trust Biomedical Research Centre (SLAM BRC) case register: development and descriptive dataRobert Stewart
King s College London, Institute of Psychiatry, London, UK
BMC Psychiatry 9:51. 2009..Recent developments in electronic medical records, and in computer software to search and analyse these in anonymised format, have the potential to revolutionise this research tool...
- Towards automatic recognition of scientifically rigorous clinical research evidenceHalil Kilicoglu
Department of Computer Science and Software Engineering, Concordia University, 1515 Ste Catherine West, Montreal, QC, H3G 1M8, Canada
J Am Med Inform Assoc 16:25-31. 2009..Our results demonstrate that a high quality gold standard and advanced classification methods can help clinicians acquire best evidence from the medical literature...
- The Unified Medical Language System (UMLS): integrating biomedical terminologyOlivier Bodenreider
Lister Hill Center for Biomedical Communications, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA
Nucleic Acids Res 32:D267-70. 2004..All vocabularies are available at no fee for research purposes within an institution, but UMLS users are required to sign a license agreement. The UMLS knowledge sources are distributed on CD-ROM and by FTP...
- The relation between funding by the National Institutes of Health and the burden of diseaseC P Gross
Robert Wood Johnson Clinical Scholars Program, Johns Hopkins University School of Medicine, Baltimore, USA
N Engl J Med 340:1881-7. 1999..The Institute of Medicine has proposed that the amount of disease-specific research funding provided by the National Institutes of Health (NIH) be systematically and consistently compared with the burden of disease for society...
- The poor availability of psychological research data for reanalysisJelte M Wicherts
Department of Psycology, Psychological Methods, University of Amsterdam, Roetersstraat, Amsterdam, The Netherlands
Am Psychol 61:726-8. 2006
- Emerging concepts in biomarker discovery; the US-Japan Workshop on Immunological Molecular Markers in OncologyHideaki Tahara
Department of Surgery and Bioengineering, Advanced Clinical Research Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
J Transl Med 7:45. 2009..The institution of an interactive consortium for high throughput molecular monitoring of clinical trials with voluntary participation might provide cost-effective solutions...
- Outcome of a workshop on applications of protein models in biomedical researchTorsten Schwede
Swiss Institute of Bioinformatics, Biozentrum, University of Basel, Klingelbergstrasse 50 70, CH 4056 Basel, Switzerland
Structure 17:151-9. 2009We describe the proceedings and conclusions from the "Workshop on Applications of Protein Models in Biomedical Research" (the Workshop) that was held at the University of California, San Francisco on 11 and 12 July, 2008...
- Integrating qualitative research with trials in systematic reviewsJames Thomas
Evidence for Policy and Practice Information and Coordinating (EPPI) Centre, Social Science Research Unit, Institute of Education, London WC1H 0NR
BMJ 328:1010-2. 2004
- Empirical study of data sharing by authors publishing in PLoS journalsCaroline J Savage
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA
PLoS ONE 4:e7078. 2009..These policies are explicit, but remain largely untested. We sought to determine how well authors comply with such policies by requesting data from authors who had published in one of two journals with clear data sharing policies...
- American medical education 100 years after the Flexner reportMolly Cooke
Department of Medicine, University of California, San Francisco, San Francisco, USA
N Engl J Med 355:1339-44. 2006
- Chinese authors do need CONSORT: reporting quality assessment for five leading Chinese medical journalsLin Xu
Chinese Cochrane Centre, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China
Contemp Clin Trials 29:727-31. 2008..This study aims to evaluate the reporting quality of randomized controlled trials (RCTs) published in the five leading Chinese medical journals indexed by MEDLINE...
- Where is the evidence that animal research benefits humans?Pandora Pound
Department of Social Medicine, University of Bristol, Bristol BS8 2PR
BMJ 328:514-7. 2004
- Guest authorship and ghostwriting in publications related to rofecoxib: a case study of industry documents from rofecoxib litigationJoseph S Ross
Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, New York 10029, USA
JAMA 299:1800-12. 2008..Recent litigation related to rofecoxib provided a unique opportunity to examine guest authorship and ghostwriting, practices that have been suspected in biomedical publication but for which there is little documentation...
- A glossary for dissemination and implementation research in healthBorsika A Rabin
Department of Community Health and Prevention Research Center, School of Public Health, Saint Louis University, 3545 Lafayette Ave, Salus Center 475, St Louis, MO 63104, USA
J Public Health Manag Pract 14:117-23. 2008....
- Informed consent in biobank research: a deliberative approach to the debateDavid M Secko
Department of Journalism, Concordia University, 7141 Sherbrooke St West, Montreal, QC, Canada
Soc Sci Med 68:781-9. 2009..In this context, there was persistent disagreement about when consent was required for new research activities...
- Developing a framework for transferring knowledge into action: a thematic analysis of the literatureVicky Ward
Leeds Institute of Health Sciences, University of Leeds, Leeds, UK
J Health Serv Res Policy 14:156-64. 2009..This paper describes the development of a conceptual framework of translating knowledge into action and discusses how it can be used for developing a useful model of the knowledge transfer process...
- Growing applications of "click chemistry" for bioconjugation in contemporary biomedical researchKido Nwe
Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1002, USA
Cancer Biother Radiopharm 24:289-302. 2009..g., biocompatibility, selectivity, yield, stereospecificity, and so forth); thus, one can expect it will consequently become a more routine strategy in the near future for a wide range of applications...
- The distribution of biomedical research resources and international justiceDavid B Resnik
Department of Medical Humanities New Programs, The Bioethics Center 2S 17 Brody Building, The Brody School of Medicine, East Carolina University Greenville, NC 27858 4354 USA
Dev World Bioeth 4:42-57. 2004According to some estimates, less than 10% of the world's biomedical research funds are dedicated to addressing problems that are responsible for 90% of the world's burden of disease...
- Cross-species transfer of viruses: implications for the use of viral vectors in biomedical research, gene therapy and as live-virus vaccinesDerrick Louz
GMO Office, Substances Expertise Centre of the National Institute of Public Health and the Environment, Bilthoven, The Netherlands
J Gene Med 7:1263-74. 2005..the intensified use of viruses and their genetically modified variants as viral gene transfer vectors for biomedical research, experimental gene therapy and for live-vector vaccines is a cause for concern...
- Advancing translational research with the Semantic WebAlan Ruttenberg
Millennium Pharmaceuticals, Cambridge, MA, USA
BMC Bioinformatics 8:S2. 2007....
- Evaluation of email alerts in practice: Part 2. Validation of the information assessment methodPierre Pluye
Department of Family Medicine, McGill University, Montreal, Canada
J Eval Clin Pract 16:1236-43. 2010..The purpose of the present paper (Part 2) is to examine the content validity of the IAM cognitive checklist when linked to email alerts...
- The ongoing tyranny of statistical significance testing in biomedical researchAndreas Stang
Institut für Klinische Epidemiologie, Medizinische Fakultat, Martin Luther Universitat Halle Wittenberg, Magdeburger Str 8, 06097, Halle Saale, Germany
Eur J Epidemiol 25:225-30. 2010..For a proper interpretation of study results, both estimated effect size and estimated precision are necessary ingredients...
- Toward a national framework for the secondary use of health data: an American Medical Informatics Association White PaperCharles Safran
American Medical Informatics Association, 4915 St Elmo Avenue, Suite 401, Bethesda, MD 20814, USA
J Am Med Inform Assoc 14:1-9. 2007..Such a framework can guide and facilitate widespread collection, storage, aggregation, linkage, and transmission of health data. The framework will provide appropriate protections for legitimate secondary use...
- Funding of US biomedical research, 2003-2008E Ray Dorsey
Department of Neurology, University of Rochester Medical Center, Rochester, New York, USA
JAMA 303:137-43. 2010With the exception of the American Recovery and Reinvestment Act, funding support for biomedical research in the United States has slowed after a decade of doubling. However, the extent and scope of slowing are largely unknown.
- Precompetitive preclinical ADME/Tox data: set it free on the web to facilitate computational model building and assist drug developmentSean Ekins
Collaborations in Chemistry, Jenkintown, PA 19046, USA
Lab Chip 10:13-22. 2010..cleaned and then published to the ChemSpider or other database such that it will be freely available to the biomedical research and clinical communities...
- A bibliometric analysis by geographic area of published research in several biomedical fields, 1995-2003Matthew E Falagas
Alfa Institute of Biomedical Sciences, Athens, Greece
CMAJ 175:1389-90. 2006..However, after adjustments for GDP, Canada ranked first, with the United States and Oceania following closely behind. All of the developing regions had only small research contributions in all of the biomedical fields examined...
- Successful aging and sustained good health in the naked mole rat: a long-lived mammalian model for biogerontology and biomedical researchYael H Edrey
The Sam and Ann Barshop Institute for Longevity and Aging Studies, 15355 Lambda Drive, San Antonio, TX 78245, USA
ILAR J 52:41-53. 2011..Elucidating these mechanisms will provide useful information for enhancing human life- and healthspan, making the naked mole rat a true "supermodel" for aging research and resistance to chronic age-associated diseases...
- The 10/90 gap in sub-Saharan Africa: resolving inequities in health researchWen L Kilama
African Malaria Network Trust, Dares Salaam, Tanzania
Acta Trop 112:S8-S15. 2009..We conclude that despite the many capacity strengthening actions, and achievements made towards resolving the 10/90 gap, the disequilibrium still persists; there is need for greater investments aimed at closing it...
- Current trends in antimicrobial agent research: chemo- and bioinformatics approachesRiadh Hammami
STELA Dairy Research Center, Nutraceuticals and Functional Foods Institute, Universite Laval, Quebec, QC, Canada
Drug Discov Today 15:540-6. 2010..This article reviews progress in the development of computational methods, tools and databases used for organizing and extracting biological meaning from antimicrobial research...
- Future developments of medical informatics from the viewpoint of networked clinical research. Interoperability and integrationC Ohmann
Coordination Centre for Clinical Trials, Heinrich Heine University, Moorenstr 5, 40225 Duesseldorf, Germany
Methods Inf Med 48:45-54. 2009..It is the objective of our paper to give an overview of developments, indicate problem areas and to specify future requirements...
- Implications of correlations between skin color and genetic ancestry for biomedical researchE J Parra
Department of Anthropology, University of Toronto at Mississauga, Mississauga, Ontario L5L 1C6, Canada
Nat Genet 36:S54-60. 2004....
- Reporting recommendations for tumor marker prognostic studies (REMARK)Lisa M McShane
Biometric Research Branch, National Cancer Institute, Executive Plaza North, 6130 Executive Blvd, Bethesda, MD 20892 7434, USA
J Natl Cancer Inst 97:1180-4. 2005....
- Pre-clinical PET/MR: technological advances and new perspectives in biomedical researchHans F Wehrl
Department of Radiology, Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens Foundation, University of Tubingen, Röntgenweg 13, 72076, Tubingen, Germany
Eur J Nucl Med Mol Imaging 36:S56-68. 2009..Especially in small-animal research, where high soft tissue contrast is required, and the scan time as well as radiation dose are critical factors, the combination of PET and MRI would be beneficial compared with PET/CT...
- The textual characteristics of traditional and Open Access scientific journals are similarKarin Verspoor
Center for Computational Pharmacology, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
BMC Bioinformatics 10:183. 2009..If this assumption is wrong, the cost to the community will be large, including not just wasted resources, but also flawed science. This paper examines that assumption...
- Transgenic pigs as models for translational biomedical researchBernhard Aigner
Department of Veterinary Sciences and Laboratory for Functional Genome Analysis LAFUGA, Gene Center, LMU Munich, Feodor Lynen Str 25, 81377 Munich, Germany
J Mol Med (Berl) 88:653-64. 2010..This article provides an overview of the current techniques for genetic modification of pigs and the transgenic pig models established for neurodegenerative diseases, cardiovascular diseases, cystic fibrosis, and diabetes mellitus...
- A new trade framework for global healthcare R&DTim Hubbard
Wellcome Trust Sanger Institute in Hinxton, United Kingdom
PLoS Biol 2:E52. 2004
- The meaning of translational research and why it mattersSteven H Woolf
Department of Family Medicine, Virginia Commonwealth University, West Hospital, 1200 E Broad St, PO Box 980251, Richmond, VA 23298-0251, USA
JAMA 299:211-3. 2008
- Do effectiveness ("real world") studies on antipsychotics tell us the real truth?Hans Jurgen Moller
Department of Psychiatry, Ludwig Maximilians University Munchen, Nussbaumstrasse 7, 80336, Munich, Germany
Eur Arch Psychiatry Clin Neurosci 258:257-70. 2008..The main conclusions of these trials will be questioned on the basis of their severe methodological pitfalls...
- 'Fair benefits' accounts of exploitation require a normative principle of fairness: response to Gbadegesin and Wendler, and Emanuel et alAngela Ballantyne
Institution for Social and Policy Studies, Interdisciplinary Center for Bioethics, Yale University, New Haven, CT 06520 8029, USA
Bioethics 22:239-44. 2008..I conclude, however, that the utility of the fair benefits model of exploitation as a policy tool will ultimately depend on whether a substantive principle of fairness can be developed to underpin it...
- Nutrigenomics research for personalized nutrition and medicineJim Kaput
Division of Personalized Nutrition and Medicine, FDA National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA
Curr Opin Biotechnol 19:110-20. 2008....
- Ethical issues in research in low-income countriesS R Benatar
Bioethics Centre, Department of Medicine, University of Cape Town, Western Cape, South Africa
Int J Tuberc Lung Dis 11:617-23. 2007....
- An update on biomarkers of bone turnover and their utility in biomedical research and clinical practiceD J Leeming
Nordic Bioscience Diagnostics A S, 2730, Herlev, Denmark
Eur J Clin Pharmacol 62:781-92. 2006..Numerous studies have provided evidence that serum levels or urinary excretion of these biomarkers correlate with the rate of bone loss and fracture risk, proving them as useful tools for improving identification of high-risk patients...
- Critical appraisal of qualitative research in clinical journals challengedJoanna E M Sale
Arthritis Rheum 53:314-6. 2005
- Sources of variation and bias in studies of diagnostic accuracy: a systematic reviewPenny Whiting
University of York, York, United Kingdom
Ann Intern Med 140:189-202. 2004..Studies of diagnostic accuracy are subject to different sources of bias and variation than studies that evaluate the effectiveness of an intervention. Little is known about the effects of these sources of bias and variation...
- Alternative consent models for biobanks: the new Spanish law on biomedical researchAntonio Casado da Rocha
University of the Basque Country UPV EHU, Filosofia de los Valores y Antropologia Social, 70 FICE San Sebastian, Gipuzkoa 20018, Spain
Bioethics 22:440-7. 2008..samples, as well as a country report about how this issue has been regulated in Spain by means of the new Biomedical Research Act, enacted in the summer of 2007...
- Ethnopharmacological field studies: a critical assessment of their conceptual basis and methodsMichael Heinrich
Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, 29 39 Brunswick Sq, London WC1N1AX, UK
J Ethnopharmacol 124:1-17. 2009..This review cannot be a book of recipes on how to conduct such research but highlights minimal conceptual and methodological requirements for use in future projects...
- The tree shrews: adjuncts and alternatives to primates as models for biomedical researchJ Cao
Department of Pathology, Guangxi Cancer Institute, Guangxi Medical University, Nanning, China
J Med Primatol 32:123-30. 2003..However, the tree shrews holds significant promise as research models and great use could be made of these animals in biomedical research.
- Practice-based research--"Blue Highways" on the NIH roadmapJohn M Westfall
High Plains Research Network, Department of Family Medicine, University of Colorado Health Sciences Center, Denver, CO 80045, USA
JAMA 297:403-6. 2007
- A critical appraisal of propensity-score matching in the medical literature between 1996 and 2003Peter C Austin
Institute for Clinical Evaluative Sciences, Toronto, Ont, Canada
Stat Med 27:2037-49. 2008..We provide guidelines for the analysis and reporting of studies that employ propensity-score matching...
- Grand challenges in chronic non-communicable diseasesAbdallah S Daar
Program on Life Sciences, Ethics and Policy, McLaughlin-Rotman Centre for Global Health, University Health Network/University of Toronto, 101 College Street, Toronto, Ontario, M5G 1L7, Canada
Nature 450:494-6. 2007
- HIV vaccine research: the way forwardAnthony S Fauci
National Institute of Allergy and Infectious Diseases, National Institutes of Health, 31 Center Drive, Bethesda, MD 20892, USA
Science 321:530-2. 2008..In an era of a level budget for biomedical research at the U.S...
- The Spanish HIV BioBank: a model of cooperative HIV researchIsabel García-Merino
Hospital General Universitario Gregorio Maranon, Madrid, Spain
Retrovirology 6:27. 2009..To carry out quality research that could eventually end in a personalized treatment for HIV, it is essential to guarantee the availability, quality and traceability of samples, under a strict system of quality management...
- Translational research: crossing the valley of deathDeclan Butler
Nature 453:840-2. 2008
- Dissemination and publication of research findings: an updated review of related biasesF Song
School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, UK
Health Technol Assess 14:iii, ix-xi, 1-193. 2010....
- The effect of privacy legislation on observational researchAndrea S Gershon
Department of Medicine, University of Toronto and the Institute for Clinical Evaluative Sciences, Toronto, Ont
CMAJ 178:871-3. 2008
- Opportunities and limitations of SELDI-TOF-MS in biomedical research: practical advicesTerence C W Poon
Li Ka Shing Institute of Health Sciences, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, China
Expert Rev Proteomics 4:51-65. 2007..This review provides an overview of the surface-enhanced laser desorption/ionization time-of-flight mass spectrometry, discusses its limitations and provides some possible solutions to help apply this technology to biomarker research...
- Retractions in the scientific literature: is the incidence of research fraud increasing?R Grant Steen
Medical Communications Consultants, LLC 103 Van Doren Place, Chapel Hill, NC 27517, USA
J Med Ethics 37:249-53. 2011..Growing attention to fraud in the lay press suggests that the incidence of fraud is increasing...
- Participants' perceptions of motivation, randomisation and withdrawal in a randomised controlled trial of interventions for prevention of depressionJ Busby Grant
Centre for Applied Psychology Faculty of Health, University of Canberra, Canberra, ACT 2601, Australia
J Med Ethics 35:768-73. 2009..This study examined participants' motives for participating in a trial and their views of randomisation and the ability to withdraw from a randomised controlled trial (RCT) for prevention of depression...
- Public good, personal privacy: a citizens' deliberation about using medical information for pharmacoepidemiological researchLianne Parkin
Department of Preventive and Social Medicine, University of Otago, Dunedin, New Zealand
J Epidemiol Community Health 65:150-6. 2011..How the public weighs up these public interest and privacy arguments is unclear...
- The NIH-NIAID schistosomiasis resource centerFred A Lewis
Biomedical Research Institute, Rockville, Maryland, United States of America
PLoS Negl Trop Dis 2:e267. 2008....
- At what age do biomedical scientists do their best work?Matthew E Falagas
Alfa Institute of Biomedical Sciences, 9 Neapoleos St, 151 23 Marousi, Athens, Greece
FASEB J 22:4067-70. 2008..In conclusion, high-quality scientific productivity in the biomedical fields as a function of investigator's age plots an inverted U-shaped curve, in which significant decreases take place from around 40 yr of age and beyond...
- The REUSE project: EHR as single datasource for biomedical researchAbdennaji El Fadly
INSERM, UMR_S 872, Paris, F 75006 France
Stud Health Technol Inform 160:1324-8. 2010Integrating biomedical research and patient care is a challenging issue requiring interoperability solutions...
- Sex and sensitivity: the continued need for sex-based biomedical research and implementationCandace M Tingen
Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
Womens Health (Lond Engl) 6:511-6. 2010The phrase 'women's health research' embraces women as part of the biomedical research engine while categorizing women as separate...
- The relationship between "race" and genetics in biomedical researchJada Benn Torres
Section of Genetic Medicine, Department of Medicine, The University of Chicago, 5841 South Maryland Avenue, MC6091, Chicago, IL 60637, USA
Curr Hypertens Rep 9:196-201. 2007The post-human genome sequencing era has presented several daunting challenges for biomedical research. How do we begin to quantify the level of sequence variation that exists within and between human populations? This challenge has ..
- Identifying and prioritizing uncertainties: patient and clinician engagement in the identification of research questionsGlyn Elwyn
Department of Primary Care and Public Health School of Medicine, Cardiff University, Neuadd Meirionnydd, UK
J Eval Clin Pract 16:627-31. 2010....
- Participation in biomedical research is an imperfect moral duty: a response to John HarrisSandra Shapshay
Department of Philosophy, Indiana University, 1033 E Third Street, Bloomington, IN 47405, USA
J Med Ethics 33:414-7. 2007..research is a moral duty", John Harris argues that individuals have a moral duty to participate in biomedical research by volunteering as research subjects...
- The first chimpanzee sanctuary in Japan: an attempt to care for the "surplus" of biomedical researchNaruki Morimura
Wildlife Research Center, Kyoto University, Kumamoto, Japan
Am J Primatol 73:226-32. 2011..We discuss our ethical responsibility for captive chimpanzees that have been used in biomedical research. On April 1, 2007, the Chimpanzee Sanctuary Uto (CSU) was established as the first sanctuary for retired ..
- Stroke: working toward a prioritized world agendaVladimir Hachinski
University of Western Ontario, University Hospital, 339 Windermere Road, London, Ontario, Canada N6A 5A5, USA
Stroke 41:1084-99. 2010..The aim of the Synergium was to devise and prioritize new ways of accelerating progress in reducing the risks, effects, and consequences of stroke...
- Canadian Network and Centre for Trials Internationally (CANNeCTIN): a national network for Canadian-led trials in cardiovascular diseases and diabetes mellitusJohn A Cairns
University of British Columbia, Vancouver, British Columbia
Can J Cardiol 26:353-8. 2010....
- Taking tissue seriously means taking communities seriouslyRoss E G Upshur
University of Toronto Joint Centre for Bioethics, 88 College Street, Toronto, Ontario, M5G 1L4, Canada
BMC Med Ethics 8:11. 2007..This often leads to the export of human tissue (defined broadly) from the developing to the developed world for analysis. These practices raise a number of important ethical issues that require attention...
- Arab nations lagging behind other Middle Eastern countries in biomedical research: a comparative studyHani T S Benamer
Department of Nephrology, Clinical Sciences, Lund University, Lund, Sweden
BMC Med Res Methodol 9:26. 2009Analysis of biomedical research and publications in a country or group of countries is used to monitor research progress and trends...
- Why do people refuse to take part in biomedical research studies? Evidence from a resource-poor areaJoseph Mfutso-Bengo
Centre for Bioethics in Eastern and Southern Africa, College of Medicine, Malawi
Malawi Med J 20:57-63. 2008..We conducted focus group discussions with people who had refused to take part in a number of biomedical research studies but agreed to be interviewed in this study...
- Proceedings of the Conference on Swine in Biomedical ResearchJohn K Critser
Department of Veterinary Pathobiology, University of Missouri, N132 RADIL, 4011 Discovery Drive, Columbia, MO 65201, USA
ILAR J 50:89-94. 2009The Conference on Swine in Biomedical Research was held April 2-3, 2008, in San Diego, California...
- Research with vulnerable human beingsGodfrey B Tangwa
University of Yaounde, Yaounde, Cameroon
Acta Trop 112:S16-20. 2009....
- Is the randomized controlled drug trial in Europe lagging behind the USA?Hiddo J Lambers Heerspink
Department of Clinical Pharmacology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
Br J Clin Pharmacol 66:774-80. 2008..The purpose of this study was to benchmark Europe's position on drugRCTs relative to the rest of the world, and to identify factors that may drive this performance...
- Current status of sperm cryopreservation in biomedical research fish models: zebrafish, medaka, and XiphophorusHuiping Yang
Aquaculture Research Station, Louisiana Agricultural Experiment Station, Louisiana State University Agricultural Center, 2410 Ben Hur Road, Baton Rouge, Louisiana 70820, USA
Comp Biochem Physiol C Toxicol Pharmacol 149:224-32. 2009Aquarium fishes are becoming increasingly important because of their value in biomedical research and the ornamental fish trade, and because many have become threatened or endangered in the wild...
- The need for veterinarians in biomedical researchThomas J Rosol
College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
J Vet Med Educ 36:70-5. 2009The number of veterinarians in the United States is inadequate to meet societal needs in biomedical research and public health...
- Ethics committees for biomedical research in some African emerging countries: which establishment for which independence? A comparison with the USA and CanadaJean Paul Rwabihama
Joffre Dupuytren Hospital, Assistance Publique Hopitaux de Paris AP HP, 91210 Draveil, France
J Med Ethics 36:243-9. 2010..This reading should benefit from an independent local ethical review of protocols. Consequently, ethics committees for medical research are evolving in Africa...
- Increasing contribution of China in modern biomedical research. Statistical data from ISI Web of KnowledgeGregory C Makris
Alfa Institute of Biomedical Sciences, Athens, Greece
Med Sci Monit 15:SR15-21. 2009..However, the last two decades under the pressure of globalization Chinese medicine is turning gradually to evidence-based medicine, contributing in international biomedical research.
- The BRIDG project: a technical reportDouglas B Fridsma
Department of Biomedical Informatics, Arizona State University, Phoenix, AZ 85004 2157, USA
J Am Med Inform Assoc 15:130-7. 2008The Biomedical Research Integrated Domain Group (BRIDG) project is a collaborative initiative between the National Cancer Institute (NCI), the Clinical Data Interchange Standards Consortium (CDISC), the Regulated Clinical Research ..
- Identifying the "vulnerables" in biomedical research: the vox populis from the Tuskegee Legacy ProjectChristopher T Chiu
Department of Epidemiology and Health Promotion, NYU College of Dentistry, 250 Park Ave South, NY, NY 10003, USA
J Public Health Dent 71:220-8. 2011This report presents, for the first time, findings on the vox populis as to who constitutes the "vulnerables in biomedical research"
- Veterinarians in biomedical research: building national capacityDaryl D Buss
School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706, USA
J Vet Med Educ 36:62-9. 2009..Summary provides the conclusions from the presentations and discussions at the conference Veterinarians in Biomedical Research-Building National Capacity, a meeting coordinated by the AAVMC and held at the National Institutes of ..
- What makes clinical research in developing countries ethical? The benchmarks of ethical researchEzekiel J Emanuel
Department of Clinical Bioethics, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 1156, USA
J Infect Dis 189:930-7. 2004
- Enhancing cancer control programmatic and research opportunities for African-Americans through technical assistance trainingDavid Satcher
Office of the President and Department of Community Health and Preventive Medicine, Morehouse School of Medicine, Atlanta, Georgia, USA
Cancer 107:1955-61. 2006..Technical assistance may improve minority recruitment/retention in CBPR cancer control research and enhance understanding and elimination of cancer health disparities among African-Americans. Cancer 2006. (c) American Cancer Society...
- Open access publishing in the biomedical sciences: could funding agencies accelerate the inevitable changes?Steven William Glover
Librarian, Christie Hospital NHS Trust, Manchester, UK
Health Info Libr J 23:197-202. 2006..Of particular note was the stipulation that authors receiving grants must deposit their final manuscript in an open access forum within 6-12 months of publication...
- Academic medical centers' standards for clinical-trial agreements with industryMichelle M Mello
Department of Health Policy and Management, Harvard School of Public Health, Boston, MA 02115, USA
N Engl J Med 352:2202-10. 2005..We studied institutional standards regarding contractual provisions that restrict investigators' control over trials...
- The drug industry and clinical research in interwar America: three types of physician collaboratorNicolas Rasmussen
School of History and Philosophy of Science, University of New South Wales, Sydney, NSW 2052, Australia
Bull Hist Med 79:50-80. 2005..These patterns may help illuminate the mutual accommodation between ethical drug firms and academic clinical researchers (and institutions) that still prevails today...
- Veterans Administration support for medical research: opinions of the endangered species of physician-scientistsStanley Zucker
Veterans Administration Medical Centers, Northport, New York, USA
FASEB J 18:1481-6. 2004..4) The VA research program has fostered a mutually beneficial relationship with affiliated medical schools. 5) Better methods to quantify VA research contributions and outcomes are essential for future program development...
- Intrinsic conflicts of interest in clinical research: a need for disclosureSharmon Sollitto
Case Western University School of Law, Cleveland, OH, USA
Kennedy Inst Ethics J 13:83-91. 2003..These conflicts should be disclosed to research subjects and managed as assiduously as are financial conflicts of interest...
- IMPROVING ANIMAL RESOURCES FOR BIOMEDICAL RESEARCHSylvia Kondo; Fiscal Year: 2009..institution, is committed to maintaining the highest quality Animal Care and Use Program in support of its biomedical research, education and training programs...
- A novel transgenic silkworm system for recombinant glycoprotein productionDonald L Jarvis; Fiscal Year: 2010..Thus, there is a high demand for systems that can be used to produce recombinant glycoproteins for basic biomedical research and direct clinical applications...
- A novel transgenic silkworm system for recombinant glycoprotein productionDonald Jarvis; Fiscal Year: 2007..Thus, there is a high demand for systems that can be used to produce recombinant glycoproteins for basic biomedical research and direct clinical applications...
- A novel transgenic silkworm system for recombinant glycoprotein productionDonald Jarvis; Fiscal Year: 2009..Thus, there is a high demand for systems that can be used to produce recombinant glycoproteins for basic biomedical research and direct clinical applications...
- Nanoassay for Realtime Molecular Probing ABC TransporterXiaohong Xu; Fiscal Year: 2009..center and enabling access to state-of-the-art instrumentation available at the center and thereby advance biomedical research. The justifications of this revision are given below: The study of membrane proteins at the molecular level ..
- EXTRAMURAL RESEARCH FACILITIES IMPROVEMENT PROGRAMJohn Blake; Fiscal Year: 2005..Over the past three decades the State of Alaska has had surprisingly limited participation in biomedical research and we consistently lag behind the other states and territories in NIH funding...
- RCMI-FD-Ashton Hamme, Ph.D.; Ernest B. Izevbigie, Ph.D.RONALD MASON; Fiscal Year: 2004..The Center has been structured to develop and sustain an adequate biomedical research infrastructure, and to serve as a platform to nurture and emphasize interdisciplinary research programs in ..
- EPCC'S RISE TO THE CHALLENGE PROGRAMMaria Alvarez; Fiscal Year: 2007..lead to an increase in the number of EPCC students transferring to four-year institutions and pursuing a biomedical research career...
- SHORT-TERM TRAINING: STUDENTS IN HEALTH PROFESS. SCHOOLSMichael Atchison; Fiscal Year: 2007..Recruitment of veterinarians into biomedical research careers should have a positive impact on human health...
- BIOMEDICAL RESEARCH INTERNSHIP PROGRAM FOR UNDERGRADUATESonia Flores; Fiscal Year: 2007..students to attend graduate or professional schools and continue studies that will lead to a career in biomedical research. The UCHSC has an established commitment to increasing the diversity of its student population and to ..
- New Mexico IDeA Networks of Biomedical Research Excellence (INBRE) [P20]JEFFREY ARTERBURN; Fiscal Year: 2009The purpose of the New Mexico Idea Network of Biomedical Research Excellence (NM-INBRE) is to strengthen biomedical research in New Mexico's institutions of higher education and to prepare faculty and students for participation in ..