biomedical research

Summary

Summary: Research that involves the application of the natural sciences, especially biology and physiology, to medicine. (from American Heritage Dictionary, 4th ed)

Top Publications

  1. ncbi Central challenges facing the national clinical research enterprise
    Nancy S Sung
    Burroughs Wellcome Fund, PO Box 13901, 21 T W Alexander Dr, Research Triangle Park, NC 27709, USA
    JAMA 289:1278-87. 2003
  2. pmc Serving the enterprise and beyond with informatics for integrating biology and the bedside (i2b2)
    Shawn N Murphy
    Laboratory of Computer Science, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
    J Am Med Inform Assoc 17:124-30. 2010
  3. ncbi Reporting recommendations for tumor marker prognostic studies (REMARK)
    Lisa M McShane
    Biometric Research Branch, National Cancer Institute, Executive Plaza North, 6130 Executive Blvd, Bethesda, MD 20892 7434, USA
    J Natl Cancer Inst 97:1180-4. 2005
  4. pmc The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies
    Erik von Elm
    Institute of Social and Preventive Medicine ISPM, University of Bern, Bern, Switzerland
    PLoS Med 4:e296. 2007
  5. doi Impact of high-throughput screening in biomedical research
    Ricardo Macarron
    Department of Sample Management Technologies, GlaxoSmithKline, Mail Stop UP 12 200, 1250S Collegeville Rd, Collegeville, Pennsylvania 19426, USA
    Nat Rev Drug Discov 10:188-95. 2011
  6. ncbi Practice-based research--"Blue Highways" on the NIH roadmap
    John M Westfall
    High Plains Research Network, Department of Family Medicine, University of Colorado Health Sciences Center, Denver, CO 80045, USA
    JAMA 297:403-6. 2007
  7. ncbi Translating clinical research into clinical practice: impact of using prediction rules to make decisions
    Brendan M Reilly
    Cook County Stroger Hospital and Rush Medical College, Chicago, Illinois 60612, USA
    Ann Intern Med 144:201-9. 2006
  8. pmc Guidance for developers of health research reporting guidelines
    David Moher
    Ottawa Methods Centre, Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
    PLoS Med 7:e1000217. 2010
  9. pmc Assessing country-level efforts to link research to action
    John N Lavis
    McMaster University, Hamilton, Ontario, Canada
    Bull World Health Organ 84:620-8. 2006
  10. pmc Relations in biomedical ontologies
    Barry Smith
    Institute for Formal Ontology and Medical Information Science, Saarland University, D 66041 Saarbrucken, Germany
    Genome Biol 6:R46. 2005

Detail Information

Publications341 found, 100 shown here

  1. ncbi Central challenges facing the national clinical research enterprise
    Nancy S Sung
    Burroughs Wellcome Fund, PO Box 13901, 21 T W Alexander Dr, Research Triangle Park, NC 27709, USA
    JAMA 289:1278-87. 2003
    ....
  2. pmc Serving the enterprise and beyond with informatics for integrating biology and the bedside (i2b2)
    Shawn N Murphy
    Laboratory of Computer Science, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
    J Am Med Inform Assoc 17:124-30. 2010
    ..The current version of this software has been released into the public domain and is available at the URL: http://www.i2b2.org/software...
  3. ncbi Reporting recommendations for tumor marker prognostic studies (REMARK)
    Lisa M McShane
    Biometric Research Branch, National Cancer Institute, Executive Plaza North, 6130 Executive Blvd, Bethesda, MD 20892 7434, USA
    J Natl Cancer Inst 97:1180-4. 2005
    ....
  4. pmc The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies
    Erik von Elm
    Institute of Social and Preventive Medicine ISPM, University of Bern, Bern, Switzerland
    PLoS Med 4:e296. 2007
    Much biomedical research is observational. The reporting of such research is often inadequate, which hampers the assessment of its strengths and weaknesses and of a study's generalisability...
  5. doi Impact of high-throughput screening in biomedical research
    Ricardo Macarron
    Department of Sample Management Technologies, GlaxoSmithKline, Mail Stop UP 12 200, 1250S Collegeville Rd, Collegeville, Pennsylvania 19426, USA
    Nat Rev Drug Discov 10:188-95. 2011
    ..In this article, we aim to dispel these myths and present the case for the use of HTS as part of a proven scientific tool kit, the wider use of which is essential for the discovery of new chemotypes...
  6. ncbi Practice-based research--"Blue Highways" on the NIH roadmap
    John M Westfall
    High Plains Research Network, Department of Family Medicine, University of Colorado Health Sciences Center, Denver, CO 80045, USA
    JAMA 297:403-6. 2007
  7. ncbi Translating clinical research into clinical practice: impact of using prediction rules to make decisions
    Brendan M Reilly
    Cook County Stroger Hospital and Rush Medical College, Chicago, Illinois 60612, USA
    Ann Intern Med 144:201-9. 2006
    ..These considerations should inform future development, evaluation, and use of all clinical prediction or decision rules...
  8. pmc Guidance for developers of health research reporting guidelines
    David Moher
    Ottawa Methods Centre, Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
    PLoS Med 7:e1000217. 2010
    ..David Moher and colleagues from the EQUATOR network offer guidance and recommended steps for developing health research reporting guidelines...
  9. pmc Assessing country-level efforts to link research to action
    John N Lavis
    McMaster University, Hamilton, Ontario, Canada
    Bull World Health Organ 84:620-8. 2006
    ..The fourth element addresses approaches to evaluation (how support is provided for rigorous evaluations of efforts to link research to action)...
  10. pmc Relations in biomedical ontologies
    Barry Smith
    Institute for Formal Ontology and Medical Information Science, Saarland University, D 66041 Saarbrucken, Germany
    Genome Biol 6:R46. 2005
    ..The resulting Relation Ontology can promote interoperability of ontologies and support new types of automated reasoning about the spatial and temporal dimensions of biological and medical phenomena...
  11. doi Transgenic pigs as models for translational biomedical research
    Bernhard Aigner
    Department of Veterinary Sciences and Laboratory for Functional Genome Analysis LAFUGA, Gene Center, LMU Munich, Feodor Lynen Str 25, 81377 Munich, Germany
    J Mol Med (Berl) 88:653-64. 2010
    ..This article provides an overview of the current techniques for genetic modification of pigs and the transgenic pig models established for neurodegenerative diseases, cardiovascular diseases, cystic fibrosis, and diabetes mellitus...
  12. doi Recent advances in three-dimensional multicellular spheroid culture for biomedical research
    Ruei Zeng Lin
    Institute of Molecular Medicine, National Tsing Hua University, Hsin Chu, Taiwan
    Biotechnol J 3:1172-84. 2008
    ..Here we review the current understanding of multicellular spheroid formation mechanisms, their biomedical applications, and recent advances in spheroid culture, manipulation, and analysis techniques...
  13. ncbi Interventions to improve research participants' understanding in informed consent for research: a systematic review
    James Flory
    Department of Clinical Bioethics, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    JAMA 292:1593-601. 2004
    ..Available data suggest that prospective research participants may frequently not understand information disclosed to them in the informed consent process. Little is known about how understanding can be improved...
  14. ncbi Comparison of PubMed and Google Scholar literature searches
    Michael E Anders
    Department of Respiratory and Surgical Technologies, College of Health Related Professions, University of Arkansas for Medical Sciences, 737, 4301 West Markham Street, Little Rock, AR 72205, USA
    Respir Care 55:578-83. 2010
    ....
  15. pmc Financing of U.S. biomedical research and new drug approvals across therapeutic areas
    E Ray Dorsey
    Department of Neurology, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS ONE 4:e7015. 2009
    We estimated U.S. biomedical research funding across therapeutic areas, determined the association with disease burden, and evaluated new drug approvals that resulted from this investment.
  16. pmc The obligation to participate in biomedical research
    G Owen Schaefer
    Department of Bioethics, The Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    JAMA 302:67-72. 2009
    The current prevailing view is that participation in biomedical research is above and beyond the call of duty...
  17. pmc From patients to partners: participant-centric initiatives in biomedical research
    Jane Kaye
    HeLEX, Department of Public Health, University of Oxford, Old Road Campus, Headington, Oxford OX3 7LF, UK
    Nat Rev Genet 13:371-6. 2012
    ..Here, we give an overview of this rapidly moving field by providing an analysis of the different PCI approaches, as well as the benefits and challenges of implementing PCIs...
  18. pmc Enhancing search efficiency by means of a search filter for finding all studies on animal experimentation in PubMed
    Carlijn R Hooijmans
    Radboud University Nijmegen Medical Centre, Central Animal Laboratory and 3R Research Centre, Geert Grooteplein Noord 29, route 231, Nijmegen, The Netherlands
    Lab Anim 44:170-5. 2010
    ....
  19. pmc The South London and Maudsley NHS Foundation Trust Biomedical Research Centre (SLAM BRC) case register: development and descriptive data
    Robert Stewart
    King s College London, Institute of Psychiatry, London, UK
    BMC Psychiatry 9:51. 2009
    ..Recent developments in electronic medical records, and in computer software to search and analyse these in anonymised format, have the potential to revolutionise this research tool...
  20. ncbi A bibliometric analysis of global trends of research productivity in tropical medicine
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences AIBS, Athens, Greece
    Acta Trop 99:155-9. 2006
    ....
  21. pmc Grand challenges in global health: community engagement in research in developing countries
    Paulina O Tindana
    Navrongo Health Research Centre in Navrongo, Ghana
    PLoS Med 4:e273. 2007
  22. pmc Where is the evidence that animal research benefits humans?
    Pandora Pound
    Department of Social Medicine, University of Bristol, Bristol BS8 2PR
    BMJ 328:514-7. 2004
  23. pmc Sex bias in neuroscience and biomedical research
    Annaliese K Beery
    Robert Wood Johnson Health and Society Scholar at University of California, San Francisco, CA, USA
    Neurosci Biobehav Rev 35:565-72. 2011
    Female mammals have long been neglected in biomedical research. The NIH mandated enrollment of women in human clinical trials in 1993, but no similar initiatives exist to foster research on female animals...
  24. pmc Developing a framework for transferring knowledge into action: a thematic analysis of the literature
    Vicky Ward
    Leeds Institute of Health Sciences, University of Leeds, Leeds, UK
    J Health Serv Res Policy 14:156-64. 2009
    ..This paper describes the development of a conceptual framework of translating knowledge into action and discusses how it can be used for developing a useful model of the knowledge transfer process...
  25. pmc Data standards for clinical research data collection forms: current status and challenges
    Rachel L Richesson
    Department of Pediatrics, University of South Florida College of Medicine, Tampa, Florida, USA
    J Am Med Inform Assoc 18:341-6. 2011
    ....
  26. pmc The evolving field of imaging mass spectrometry and its impact on future biological research
    Jeramie D Watrous
    Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA
    J Mass Spectrom 46:209-22. 2011
    ....
  27. pmc Engaging diverse communities participating in clinical trials: case examples from across Africa
    Aceme Nyika
    African Malaria Network Trust AMANET, P, O, Box 33207, Dar es Salaam, Tanzania
    Malar J 9:86. 2010
    ..The African Malaria Network Trust (AMANET) is a pan-African non-governmental organization that sponsors and technically supports malaria vaccine trials in various African countries...
  28. doi The use and reporting of multiple imputation in medical research - a review
    A MacKinnon
    Centre for Youth Mental Health, University of Melbourne, Parkville, Victoria, Australia
    J Intern Med 268:586-93. 2010
    ..This paper sought to document the use of MI in general medical journals and to evaluate the information provided to readers about the application of the procedure in studies...
  29. doi Designing and reporting clinical trials on treatments for cutaneous leishmaniasis
    Urbà González
    Department of Dermatology, Research Unit for Evidence Based Dermatology, Hospital Plató, Barcelona, Spain
    Clin Infect Dis 51:409-19. 2010
    ....
  30. ncbi Successful aging and sustained good health in the naked mole rat: a long-lived mammalian model for biogerontology and biomedical research
    Yael H Edrey
    The Sam and Ann Barshop Institute for Longevity and Aging Studies, 15355 Lambda Drive, San Antonio, TX 78245, USA
    ILAR J 52:41-53. 2011
    ..Elucidating these mechanisms will provide useful information for enhancing human life- and healthspan, making the naked mole rat a true "supermodel" for aging research and resistance to chronic age-associated diseases...
  31. pmc Aligning community engagement with traditional authority structures in global health research: a case study from northern Ghana
    Paulina O Tindana
    McLaughlin Rotman Centre for Global Health, University of Toronto, Canada
    Am J Public Health 101:1857-67. 2011
    ..underdeveloped, and there is little empirical evidence of what makes community engagement effective in biomedical research. We chose to study the Navrongo Health Research Centre in northern Ghana because of its well-established ..
  32. pmc The role and interpretation of pilot studies in clinical research
    Andrew C Leon
    Weill Cornell Medical College, Department of Psychiatry, Box 140, 525 East 68th Street, New York, NY 10065, USA
    J Psychiatr Res 45:626-9. 2011
    ..Investigators should be forthright in stating these objectives of a pilot study. Grant reviewers and other stakeholders should expect no more...
  33. pmc Enabling collaborative research using the Biomedical Informatics Research Network (BIRN)
    Karl G Helmer
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, Massachusetts, USA
    J Am Med Inform Assoc 18:416-22. 2011
    ..The goal of the Biomedical Informatics Research Network (BIRN) is to address the challenges inherent in biomedical data sharing...
  34. doi Advances in porcine genomics and proteomics--a toolbox for developing the pig as a model organism for molecular biomedical research
    Emøke Bendixen
    Department of Animal Health and Biosciences, Arhus University, DK 8830 Tjele, Denmark
    Brief Funct Genomics 9:208-19. 2010
    ..Pigs, although not easily kept for laboratory research, are, however, readily available for biomedical research through the large scale industrial production of pigs produced for human consumption...
  35. doi Public attitudes to the use in research of personal health information from general practitioners' records: a survey of the Irish general public
    Brian S Buckley
    Department of General Practice, Clinical Sciences Institute, National University of Ireland, Galway, Ireland
    J Med Ethics 37:50-5. 2011
    ..However, few large studies have been conducted about public attitudes to research access to personal health information...
  36. pmc Never too old for anonymity: a statistical standard for demographic data sharing via the HIPAA Privacy Rule
    Bradley Malin
    Department of Biomedical Informatics, School of Medicine, Vanderbilt University, Nashville, Tennessee 37203, USA
    J Am Med Inform Assoc 18:3-10. 2011
    ..The authors propose an intuitive approach to de-identifying patient demographics in accordance with the Statistical Standard...
  37. doi Prioritizing research: Patients, carers, and clinicians working together to identify and prioritize important clinical uncertainties in urinary incontinence
    Brian S Buckley
    Department of General Practice, National University of Ireland, Galway, Ireland
    Neurourol Urodyn 29:708-14. 2010
    ..This partnership of patients and clinicians aimed to identify and prioritize "clinical uncertainties" relating to treatment of urinary incontinence (UI)...
  38. doi Contemporary low back pain research - and implications for practice
    Glenn Pransky
    Center for Disability Research, Liberty Mutual Research Institute for Safety, University of Massachusetts Medical Center, 71 Frankland Rd, Hopkinton, MA 01748, USA
    Best Pract Res Clin Rheumatol 24:291-8. 2010
    ..In this article, we review new perspectives and research studies that show promise, and suggest alternatives to current clinical and research paradigms...
  39. pmc A common layer of interoperability for biomedical ontologies based on OWL EL
    Robert Hoehndorf
    Department of Genetics, University of Cambridge, Cambridge, UK
    Bioinformatics 27:1001-8. 2011
    Ontologies are essential in biomedical research due to their ability to semantically integrate content from different scientific databases and resources...
  40. pmc Surveys of current status in biomedical science grant review: funding organisations' and grant reviewers' perspectives
    Sara Schroter
    BMJ Editorial, BMA House, London, UK
    BMC Med 8:62. 2010
    ....
  41. pmc People and organizational issues in research systems implementation
    Joan S Ash
    Department of Medical Informatics and Clinical Epidemiology, School of Medicine, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239 3098, USA
    J Am Med Inform Assoc 15:283-9. 2008
    ..Less is known about implementation of systems used for clinical and biomedical research. In conjunction with current National Institutes of Health Roadmap efforts that promote translational ..
  42. ncbi Twenty statistical errors even you can find in biomedical research articles
    Tom Lang
    Croat Med J 45:361-70. 2004
  43. ncbi Grand challenges in chronic non-communicable diseases
    Abdallah S Daar
    Program on Life Sciences, Ethics and Policy, McLaughlin Rotman Centre for Global Health, University Health Network University of Toronto, 101 College Street, Toronto, Ontario, M5G 1L7, Canada
    Nature 450:494-6. 2007
  44. pmc Sharing detailed research data is associated with increased citation rate
    Heather A Piwowar
    Department of Biomedical Informatics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 2:e308. 2007
    ..Sharing research data provides benefit to the general scientific community, but the benefit is less obvious for the investigator who makes his or her data available...
  45. doi Science communication. Interactions with the mass media
    Hans Peter Peters
    Program Group Humans Environment Technology, Forschungszentrum Julich, 52425 Julich, Germany
    Science 321:204-5. 2008
  46. pmc Evaluating the quality of research into a single prognostic biomarker: a systematic review and meta-analysis of 83 studies of C-reactive protein in stable coronary artery disease
    Harry Hemingway
    Department of Epidemiology and Public Health, University College London, United Kingdom
    PLoS Med 7:e1000286. 2010
    ..We sought to evaluate the quality of prognostic research evidence for the association of C-reactive protein (CRP) with fatal and nonfatal events among patients with stable coronary disease...
  47. ncbi Impact of the impact factor in biomedical research: its use and misuse
    V Kumar
    Department of Microbiology, Panjab University, Sector 14, Chandigarh 160014, India
    Singapore Med J 50:752-5. 2009
    The impact factor was created in the biomedical research field in order to measure a journal's value by calculating the average number of citations per article over a period of time...
  48. doi Disclosure of individual genetic data to research participants: the debate reconsidered
    Annelien L Bredenoord
    University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, Department of Medical Ethics, Stratenum 6 131, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Trends Genet 27:41-7. 2011
    ..whether genetic research results should be returned, but instead how best to make an appropriate selection and how to strike a balance between the possible benefits of disclosure and the harms of unduly hindering biomedical research.
  49. pmc STRIDE--An integrated standards-based translational research informatics platform
    Henry J Lowe
    Stanford Center for Clinical Informatics, Stanford University, Stanford CA, USA
    AMIA Annu Symp Proc 2009:391-5. 2009
    ..The system is in daily use at Stanford and is an important component of Stanford University's CTSA (Clinical and Translational Science Award) Informatics Program...
  50. doi The chick embryo: hatching a model for contemporary biomedical research
    Hassan Rashidi
    Wolfson Centre for Stem Cells, Tissue Engineering and Modelling STEM, School of Clinical Sciences, The University of Nottingham, Nottingham, UK
    Bioessays 31:459-65. 2009
    ..Here, we review novel applications of the chick embryo model, and discuss future developments of this in vivo model for biomedical research.
  51. pmc Longitudinal research and data collection in primary care
    Chris van Weel
    Department of Family Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands
    Ann Fam Med 3:S46-51. 2005
    ..This article reviews examples of and experience with longitudinal research in family medicine. The objective is to use this empirical information to formulate recommendations for improving longitudinal research...
  52. doi Mitochondrial proteomics and its application in biomedical research
    Cristina Ruiz-Romero
    Laboratorio de Investigación Osteoarticular y del Envejecimiento, Unidad de Proteómica Nodo Asociado a ProteoRed, INIBIC Complejo Hospitalario Universitario A Coruña, 15006 A Coruna, Spain
    Mol Biosyst 5:1130-42. 2009
    ..This review will focus on the state-of-art proteomic strategies in mitochondrial research, and their application to biomedicine...
  53. pmc Evaluating the informatics for integrating biology and the bedside system for clinical research
    Vikrant G Deshmukh
    Department of Biomedical Informatics, University of Utah, Salt Lake City, UT 84112, USA
    BMC Med Res Methodol 9:70. 2009
    ..We describe the evaluation of a free and open source cohort selection tool from the Informatics for Integrating Biology and the Bedside (i2b2) group: the i2b2 hive...
  54. doi A systematic review of trends in the methodological quality of randomized controlled trials in various research fields
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences AIBS, Athens, Marousi, Greece
    J Clin Epidemiol 62:227-31, 231.e1-9. 2009
    ..We sought to evaluate the trends in the methodological quality of randomized controlled trials in various medical fields...
  55. ncbi The relation between funding by the National Institutes of Health and the burden of disease
    C P Gross
    Robert Wood Johnson Clinical Scholars Program, Johns Hopkins University School of Medicine, Baltimore, USA
    N Engl J Med 340:1881-7. 1999
    ..The Institute of Medicine has proposed that the amount of disease-specific research funding provided by the National Institutes of Health (NIH) be systematically and consistently compared with the burden of disease for society...
  56. pmc Empirical study of data sharing by authors publishing in PLoS journals
    Caroline J Savage
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    PLoS ONE 4:e7078. 2009
    ..These policies are explicit, but remain largely untested. We sought to determine how well authors comply with such policies by requesting data from authors who had published in one of two journals with clear data sharing policies...
  57. pmc Integrating qualitative research with trials in systematic reviews
    James Thomas
    Evidence for Policy and Practice Information and Coordinating EPPI Centre, Social Science Research Unit, Institute of Education, London WC1H 0NR
    BMJ 328:1010-2. 2004
  58. pmc The Spanish HIV BioBank: a model of cooperative HIV research
    Isabel García-Merino
    Hospital General Universitario Gregorio Maranon, Madrid, Spain
    Retrovirology 6:27. 2009
    ..To carry out quality research that could eventually end in a personalized treatment for HIV, it is essential to guarantee the availability, quality and traceability of samples, under a strict system of quality management...
  59. doi Precompetitive preclinical ADME/Tox data: set it free on the web to facilitate computational model building and assist drug development
    Sean Ekins
    Collaborations in Chemistry, Jenkintown, PA 19046, USA
    Lab Chip 10:13-22. 2010
    ..cleaned and then published to the ChemSpider or other database such that it will be freely available to the biomedical research and clinical communities...
  60. pmc Clinical research informatics: challenges, opportunities and definition for an emerging domain
    Peter J Embi
    Center for Health Informatics, University of Cincinnati Academic Health Center, 231 Albert Sabin Way, PO Box 670840, Cincinnati, OH, 45267 0840, USA
    J Am Med Inform Assoc 16:316-27. 2009
    ..Clinical Research Informatics, an emerging sub-domain of Biomedical Informatics, is currently not well defined. A formal description of CRI including major challenges and opportunities is needed to direct progress in the field...
  61. ncbi Swine in biomedical research: creating the building blocks of animal models
    Lawrence Schook
    University of Illinois, Institute for Genomic Biology, 382 ERML, 1201 W Gregory Avenue, Urbana, IL 61801, USA
    Anim Biotechnol 16:183-90. 2005
    ..Closing discussions focused on the need for future conferences at more frequent intervals to support interactions between the various disciplines. This was especially critical because of the global distribution of investigators...
  62. ncbi Sources of variation and bias in studies of diagnostic accuracy: a systematic review
    Penny Whiting
    University of York, York, United Kingdom
    Ann Intern Med 140:189-202. 2004
    ..Studies of diagnostic accuracy are subject to different sources of bias and variation than studies that evaluate the effectiveness of an intervention. Little is known about the effects of these sources of bias and variation...
  63. ncbi The poor availability of psychological research data for reanalysis
    Jelte M Wicherts
    Department of Psycology, Psychological Methods, University of Amsterdam, Roetersstraat, Amsterdam, The Netherlands
    Am Psychol 61:726-8. 2006
  64. ncbi The Connectivity Map: a new tool for biomedical research
    Justin Lamb
    Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA
    Nat Rev Cancer 7:54-60. 2007
    The ultimate objective of biomedical research is to connect human diseases with the genes that underlie them and drugs that treat them...
  65. pmc Public opinion about the importance of privacy in biobank research
    David J Kaufman
    Genetics and Public Policy Center, Johns Hopkins University, Washington, DC 20036, USA
    Am J Hum Genet 85:643-54. 2009
    ..Survey respondents valued both privacy and participation in biomedical research. Despite pervasive privacy concerns, 60% would participate in a biobank...
  66. doi Informed consent: how much and what do patients understand?
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences AIBS, Athens, Greece
    Am J Surg 198:420-35. 2009
    ..We sought to evaluate the degree of patients' understanding of several aspects of the informed consent process for surgery and clinical research...
  67. ncbi A vision for the future of genomics research
    Francis S Collins
    National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 422:835-47. 2003
  68. pmc Translational informatics: enabling high-throughput research paradigms
    Philip R O Payne
    Department of Biomedical Informatics, The Ohio State University, Columbus, Ohio 43210, USA
    Physiol Genomics 39:131-40. 2009
    ..The objective of presenting such findings and constructs is to provide the clinical and translational research community with a common frame of reference for discussing and expanding upon such models and methodologies...
  69. pmc The Unified Medical Language System (UMLS): integrating biomedical terminology
    Olivier Bodenreider
    Lister Hill Center for Biomedical Communications, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA
    Nucleic Acids Res 32:D267-70. 2004
    ..All vocabularies are available at no fee for research purposes within an institution, but UMLS users are required to sign a license agreement. The UMLS knowledge sources are distributed on CD-ROM and by FTP...
  70. pmc Towards automatic recognition of scientifically rigorous clinical research evidence
    Halil Kilicoglu
    Department of Computer Science and Software Engineering, Concordia University, 1515 Ste Catherine West, Montreal, QC, H3G 1M8, Canada
    J Am Med Inform Assoc 16:25-31. 2009
    ..Our results demonstrate that a high quality gold standard and advanced classification methods can help clinicians acquire best evidence from the medical literature...
  71. pmc A schistosomiasis research agenda
    Daniel G Colley
    Center for Tropical and Emerging Global Diseases and Department of Microbiology, University of Georgia, Athens, Georgia, USA
    PLoS Negl Trop Dis 1:e32. 2007
    ..Partly in response to such events, we have worked with as many of those interested in schistosomiasis as we could identify to develop what we feel is a comprehensive and cohesive agenda for schistosomiasis research...
  72. ncbi REporting recommendations for tumor MARKer prognostic studies (REMARK)
    Lisa M McShane
    National Cancer Institute, Biometric Research Branch, DCTD, Room 8126, Executive Plaza North, MSC 7434, 6130 Executive Boulevard, Bethesda, MD 20892 7434, USA
    Nat Clin Pract Oncol 2:416-22. 2005
    ....
  73. pmc Emerging concepts in biomarker discovery; the US-Japan Workshop on Immunological Molecular Markers in Oncology
    Hideaki Tahara
    Department of Surgery and Bioengineering, Advanced Clinical Research Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    J Transl Med 7:45. 2009
    ..The institution of an interactive consortium for high throughput molecular monitoring of clinical trials with voluntary participation might provide cost-effective solutions...
  74. pmc Outcome of a workshop on applications of protein models in biomedical research
    Torsten Schwede
    Swiss Institute of Bioinformatics, Biozentrum, University of Basel, Klingelbergstrasse 50 70, CH 4056 Basel, Switzerland
    Structure 17:151-9. 2009
    We describe the proceedings and conclusions from the "Workshop on Applications of Protein Models in Biomedical Research" (the Workshop) that was held at the University of California, San Francisco on 11 and 12 July, 2008...
  75. doi Chinese authors do need CONSORT: reporting quality assessment for five leading Chinese medical journals
    Lin Xu
    Chinese Cochrane Centre, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China
    Contemp Clin Trials 29:727-31. 2008
    ..This study aims to evaluate the reporting quality of randomized controlled trials (RCTs) published in the five leading Chinese medical journals indexed by MEDLINE...
  76. doi Guest authorship and ghostwriting in publications related to rofecoxib: a case study of industry documents from rofecoxib litigation
    Joseph S Ross
    Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, New York 10029, USA
    JAMA 299:1800-12. 2008
    ..Recent litigation related to rofecoxib provided a unique opportunity to examine guest authorship and ghostwriting, practices that have been suspected in biomedical publication but for which there is little documentation...
  77. ncbi American medical education 100 years after the Flexner report
    Molly Cooke
    Department of Medicine, University of California, San Francisco, San Francisco, USA
    N Engl J Med 355:1339-44. 2006
  78. doi A glossary for dissemination and implementation research in health
    Borsika A Rabin
    Department of Community Health and Prevention Research Center, School of Public Health, Saint Louis University, 3545 Lafayette Ave, Salus Center 475, St Louis, MO 63104, USA
    J Public Health Manag Pract 14:117-23. 2008
    ....
  79. ncbi The emergence of biobanks in the legal landscape: towards a new model of governance
    Emmanuelle Rial-Sebbag
    Universite de Toulouse
    J Law Soc 39:113-30. 2012
    ..But is this protection adequate and sufficient? Do we need to move from the biomedical research analogy to new forms of legal protection, and governance systems which involve citizens?
  80. pmc What research impacts do Australian primary health care researchers expect and achieve?
    Richard L Reed
    Discipline of General Practice, Flinders University, Bedford Park, Adelaide, Australia
    Health Res Policy Syst 9:40. 2011
    ..This study examines the impact of individual primary health care research projects on policy and practice from the perspective of Chief Investigators (CIs)...
  81. doi Biomedical ontologies: toward scientific debate
    V Maojo
    Biomedical Informatics Group, Departamento de Inteligencia Artificial, Faculdad de Informática, Universidad Politecnica de Madrid, Boadilla del Monte, 28660 Madrid, Spain
    Methods Inf Med 50:203-16. 2011
    ..We aim to stimulate further discussion on the advantages and challenges presented by biomedical ontologies from a scientific perspective...
  82. pmc Is the use of sentient animals in basic research justifiable?
    Ray Greek
    Americans for Medical Advancement, Goleta, CA 93117, USA
    Philos Ethics Humanit Med 5:14. 2010
    ..We conclude that the use of sentient animals in basic research cannot be justified in light of society's priorities...
  83. ncbi The physician-scientist career pipeline in 2005: build it, and they will come
    Timothy J Ley
    Section of Stem Cell Biology, Division of Oncology, Department of Medicine, Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
    JAMA 294:1343-51. 2005
    ..A variety of factors were thought to contribute to this problem, including increasing indebtedness of medical school graduates caused by rapidly rising medical school tuition costs...
  84. doi Quality of reporting in sports injury prevention abstracts according to the CONSORT and STROBE criteria: an analysis of the World Congress of Sports Injury Prevention in 2005 and 2008
    Uzung Yoon
    Plastic, Hand and Reconstructive Surgery, Hannover Medical School, Carl Neuberg Street 1, Hannover, Germany
    Br J Sports Med 46:202-6. 2012
    ..The quality of reporting in congress abstracts is likely to influence clinical decision-making...
  85. doi The value of Arabidopsis research in understanding human disease states
    Xiang Ming Xu
    Centre for Organelle Research, Faculty of Science and Technology, University of Stavanger, Norway
    Curr Opin Biotechnol 22:300-7. 2011
    ..In particular, cellular processes associated with neurodegenerative disorders, such as Alzheimer's and Parkinson's disease, and the neurological disorder Friedreich Ataxia have been dissected using Arabidopsis...
  86. ncbi Cross-species transfer of viruses: implications for the use of viral vectors in biomedical research, gene therapy and as live-virus vaccines
    Derrick Louz
    GMO Office, Substances Expertise Centre of the National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    J Gene Med 7:1263-74. 2005
    ..the intensified use of viruses and their genetically modified variants as viral gene transfer vectors for biomedical research, experimental gene therapy and for live-vector vaccines is a cause for concern...
  87. doi The ongoing tyranny of statistical significance testing in biomedical research
    Andreas Stang
    Institut für Klinische Epidemiologie, Medizinische Fakultat, Martin Luther Universitat Halle Wittenberg, Magdeburger Str 8, 06097, Halle Saale, Germany
    Eur J Epidemiol 25:225-30. 2010
    ..For a proper interpretation of study results, both estimated effect size and estimated precision are necessary ingredients...
  88. pmc Toward a national framework for the secondary use of health data: an American Medical Informatics Association White Paper
    Charles Safran
    American Medical Informatics Association, 4915 St Elmo Avenue, Suite 401, Bethesda, MD 20814, USA
    J Am Med Inform Assoc 14:1-9. 2007
    ..Such a framework can guide and facilitate widespread collection, storage, aggregation, linkage, and transmission of health data. The framework will provide appropriate protections for legitimate secondary use...
  89. pmc Advancing translational research with the Semantic Web
    Alan Ruttenberg
    Millennium Pharmaceuticals, Cambridge, MA, USA
    BMC Bioinformatics 8:S2. 2007
    ....
  90. pmc Growing applications of "click chemistry" for bioconjugation in contemporary biomedical research
    Kido Nwe
    Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1002, USA
    Cancer Biother Radiopharm 24:289-302. 2009
    ..g., biocompatibility, selectivity, yield, stereospecificity, and so forth); thus, one can expect it will consequently become a more routine strategy in the near future for a wide range of applications...
  91. ncbi The distribution of biomedical research resources and international justice
    David B Resnik
    Department of Medical Humanities New Programs, The Bioethics Center 2S 17 Brody Building, The Brody School of Medicine, East Carolina University Greenville, NC 27858 4354 USA
    Dev World Bioeth 4:42-57. 2004
    According to some estimates, less than 10% of the world's biomedical research funds are dedicated to addressing problems that are responsible for 90% of the world's burden of disease...
  92. pmc Funding of US biomedical research, 2003-2008
    E Ray Dorsey
    Department of Neurology, University of Rochester Medical Center, Rochester, New York, USA
    JAMA 303:137-43. 2010
    With the exception of the American Recovery and Reinvestment Act, funding support for biomedical research in the United States has slowed after a decade of doubling. However, the extent and scope of slowing are largely unknown.
  93. pmc A bibliometric analysis by geographic area of published research in several biomedical fields, 1995-2003
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences, Athens, Greece
    CMAJ 175:1389-90. 2006
    ..However, after adjustments for GDP, Canada ranked first, with the United States and Oceania following closely behind. All of the developing regions had only small research contributions in all of the biomedical fields examined...
  94. doi Evaluation of email alerts in practice: Part 2. Validation of the information assessment method
    Pierre Pluye
    Department of Family Medicine, McGill University, Montreal, Canada
    J Eval Clin Pract 16:1236-43. 2010
    ..The purpose of the present paper (Part 2) is to examine the content validity of the IAM cognitive checklist when linked to email alerts...
  95. doi The 10/90 gap in sub-Saharan Africa: resolving inequities in health research
    Wen L Kilama
    African Malaria Network Trust, Dares Salaam, Tanzania
    Acta Trop 112:S8-S15. 2009
    ..We conclude that despite the many capacity strengthening actions, and achievements made towards resolving the 10/90 gap, the disequilibrium still persists; there is need for greater investments aimed at closing it...
  96. doi Pre-clinical PET/MR: technological advances and new perspectives in biomedical research
    Hans F Wehrl
    Department of Radiology, Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens Foundation, University of Tubingen, Röntgenweg 13, 72076, Tubingen, Germany
    Eur J Nucl Med Mol Imaging 36:S56-68. 2009
    ..Especially in small-animal research, where high soft tissue contrast is required, and the scan time as well as radiation dose are critical factors, the combination of PET and MRI would be beneficial compared with PET/CT...
  97. ncbi Implications of correlations between skin color and genetic ancestry for biomedical research
    E J Parra
    Department of Anthropology, University of Toronto at Mississauga, Mississauga, Ontario L5L 1C6, Canada
    Nat Genet 36:S54-60. 2004
    ....
  98. doi Current trends in antimicrobial agent research: chemo- and bioinformatics approaches
    Riadh Hammami
    STELA Dairy Research Center, Nutraceuticals and Functional Foods Institute, Universite Laval, Quebec, QC, Canada
    Drug Discov Today 15:540-6. 2010
    ..This article reviews progress in the development of computational methods, tools and databases used for organizing and extracting biological meaning from antimicrobial research...
  99. ncbi Future developments of medical informatics from the viewpoint of networked clinical research. Interoperability and integration
    C Ohmann
    Coordination Centre for Clinical Trials, Heinrich Heine University, Moorenstr 5, 40225 Duesseldorf, Germany
    Methods Inf Med 48:45-54. 2009
    ..It is the objective of our paper to give an overview of developments, indicate problem areas and to specify future requirements...
  100. pmc REporting recommendations for tumour MARKer prognostic studies (REMARK)
    L M McShane
    US National Cancer Institute, Bethesda, MD 20892, USA
    Br J Cancer 93:387-91. 2005
    ....

Research Grants74

  1. IMPROVING ANIMAL RESOURCES FOR BIOMEDICAL RESEARCH
    Sylvia Kondo; Fiscal Year: 2009
    ..institution, is committed to maintaining the highest quality Animal Care and Use Program in support of its biomedical research, education and training programs...
  2. A novel transgenic silkworm system for recombinant glycoprotein production
    Donald L Jarvis; Fiscal Year: 2010
    ..Thus, there is a high demand for systems that can be used to produce recombinant glycoproteins for basic biomedical research and direct clinical applications...
  3. A novel transgenic silkworm system for recombinant glycoprotein production
    Donald Jarvis; Fiscal Year: 2007
    ..Thus, there is a high demand for systems that can be used to produce recombinant glycoproteins for basic biomedical research and direct clinical applications...
  4. A novel transgenic silkworm system for recombinant glycoprotein production
    Donald Jarvis; Fiscal Year: 2009
    ..Thus, there is a high demand for systems that can be used to produce recombinant glycoproteins for basic biomedical research and direct clinical applications...
  5. Nanoassay for Realtime Molecular Probing ABC Transporter
    Xiaohong Xu; Fiscal Year: 2009
    ..center and enabling access to state-of-the-art instrumentation available at the center and thereby advance biomedical research. The justifications of this revision are given below: The study of membrane proteins at the molecular level ..
  6. EXTRAMURAL RESEARCH FACILITIES IMPROVEMENT PROGRAM
    John Blake; Fiscal Year: 2005
    ..Over the past three decades the State of Alaska has had surprisingly limited participation in biomedical research and we consistently lag behind the other states and territories in NIH funding...
  7. RCMI-FD-Ashton Hamme, Ph.D.; Ernest B. Izevbigie, Ph.D.
    RONALD MASON; Fiscal Year: 2004
    ..The Center has been structured to develop and sustain an adequate biomedical research infrastructure, and to serve as a platform to nurture and emphasize interdisciplinary research programs in ..
  8. EPCC'S RISE TO THE CHALLENGE PROGRAM
    Maria Alvarez; Fiscal Year: 2007
    ..lead to an increase in the number of EPCC students transferring to four-year institutions and pursuing a biomedical research career...
  9. SHORT-TERM TRAINING: STUDENTS IN HEALTH PROFESS. SCHOOLS
    Michael Atchison; Fiscal Year: 2007
    ..Recruitment of veterinarians into biomedical research careers should have a positive impact on human health...
  10. BIOMEDICAL RESEARCH INTERNSHIP PROGRAM FOR UNDERGRADUATE
    Sonia Flores; Fiscal Year: 2007
    ..students to attend graduate or professional schools and continue studies that will lead to a career in biomedical research. The UCHSC has an established commitment to increasing the diversity of its student population and to ..
  11. New Mexico IDeA Networks of Biomedical Research Excellence (INBRE) [P20]
    JEFFREY ARTERBURN; Fiscal Year: 2009
    The purpose of the New Mexico Idea Network of Biomedical Research Excellence (NM-INBRE) is to strengthen biomedical research in New Mexico's institutions of higher education and to prepare faculty and students for participation in ..