entropy

Summary

Summary: The measure of that part of the heat or energy of a system which is not available to perform work. Entropy increases in all natural (spontaneous and irreversible) processes. (From Dorland, 28th ed)

Top Publications

  1. ncbi Mutual information without the influence of phylogeny or entropy dramatically improves residue contact prediction
    S D Dunn
    Department of Biochemistry, University of Western Ontario, London, Ontario, Canada, N6A 5C1
    Bioinformatics 24:333-40. 2008
  2. ncbi A flexible computational framework for detecting, characterizing, and interpreting statistical patterns of epistasis in genetic studies of human disease susceptibility
    Jason H Moore
    Computational Genetics Laboratory, Department of Genetics, Dartmouth Hitchcock Medical Center, One Medical Center Dr, 706 Rubin Bldg, HB7937, Lebanon, NH 03756, USA
    J Theor Biol 241:252-61. 2006
  3. pmc Transfer entropy--a model-free measure of effective connectivity for the neurosciences
    Raul Vicente
    Max Planck Institute for Brain Research, Frankfurt, Germany
    J Comput Neurosci 30:45-67. 2011
  4. doi Transfer entropy in magnetoencephalographic data: quantifying information flow in cortical and cerebellar networks
    Michael Wibral
    Goethe University, Brain Imaging Center, MEG Unit, Heinrich Hoffmann Strasse 10, 60528 Frankfurt, Germany
    Prog Biophys Mol Biol 105:80-97. 2011
  5. ncbi Granger causality and transfer entropy are equivalent for Gaussian variables
    Lionel Barnett
    Centre for Computational Neuroscience and Robotics, School of Informatics, University of Sussex, Brighton BN1 9QJ, United Kingdom
    Phys Rev Lett 103:238701. 2009
  6. ncbi A two-entropies analysis to identify functional positions in the transmembrane region of class A G protein-coupled receptors
    Kai Ye
    Division of Medicinal Chemistry, Leiden Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands
    Proteins 63:1018-30. 2006
  7. pmc Accommodation of aminoacyl-tRNA into the ribosome involves reversible excursions along multiple pathways
    Paul C Whitford
    Center for Theoretical Biological Physics and Department of Physics, University of California, San Diego, La Jolla, California 92093, USA
    RNA 16:1196-204. 2010
  8. pmc Entropy as the driver of chromosome segregation
    Suckjoon Jun
    FAS Center for Systems Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Nat Rev Microbiol 8:600-7. 2010
  9. ncbi Prediction of G-protein-coupled receptor classes in low homology using Chou's pseudo amino acid composition with approximate entropy and hydrophobicity patterns
    Q Gu
    College of Information Sciences and Technology, Donghua University, Shanghai 201620, China
    Protein Pept Lett 17:559-67. 2010
  10. pmc Pairwise maximum entropy models for studying large biological systems: when they can work and when they can't
    Yasser Roudi
    Gatsby Computational Neuroscience Unit, University College London, London, United Kingdom
    PLoS Comput Biol 5:e1000380. 2009

Research Grants

  1. Mechanical Stress and the Heat-Treatment of Soft Tissue
    JAY HUMPHREY; Fiscal Year: 2003
  2. Consequences of Cardiac Arrest: Brain Injury
    NITISH VYOMESH THAKOR; Fiscal Year: 2010
  3. Mechanisms of Viral DNA Packaging
    CARLOS JOSE BUSTAMANTE; Fiscal Year: 2010
  4. MOLECULAR RECOGNITION IN THE STREPTAVIDIN BIOTIN SYSTEM
    Patrick Stayton; Fiscal Year: 2002
  5. PROTEIN STABILITY IN HUMAN RHINOVIRUS
    CAROL POST; Fiscal Year: 2005
  6. Topoisomerases and Chromosome Segregation
    KENNETH MARIANS; Fiscal Year: 2009
  7. Topoisomerases and Chromosome Segregation
    Kenneth J Marians; Fiscal Year: 2010
  8. Topoisomerases and Chromosome Segregation
    Kenneth J Marians; Fiscal Year: 2010
  9. Mechanisms of Allosteric Influence on Enzymes Activity
    GREGORY DUNCAN REINHART; Fiscal Year: 2010
  10. Mechanisms of Allosteric Influence on Enzymes Activity
    GREGORY DUNCAN REINHART; Fiscal Year: 2011

Detail Information

Publications249 found, 100 shown here

  1. ncbi Mutual information without the influence of phylogeny or entropy dramatically improves residue contact prediction
    S D Dunn
    Department of Biochemistry, University of Western Ontario, London, Ontario, Canada, N6A 5C1
    Bioinformatics 24:333-40. 2008
    ..However, a high background composed of random noise and phylogenetic components interferes with the identification of coevolving positions...
  2. ncbi A flexible computational framework for detecting, characterizing, and interpreting statistical patterns of epistasis in genetic studies of human disease susceptibility
    Jason H Moore
    Computational Genetics Laboratory, Department of Genetics, Dartmouth Hitchcock Medical Center, One Medical Center Dr, 706 Rubin Bldg, HB7937, Lebanon, NH 03756, USA
    J Theor Biol 241:252-61. 2006
    ..e. class entropy removed) and reduced to a single attribute using MDR...
  3. pmc Transfer entropy--a model-free measure of effective connectivity for the neurosciences
    Raul Vicente
    Max Planck Institute for Brain Research, Frankfurt, Germany
    J Comput Neurosci 30:45-67. 2011
    ..Transfer entropy (TE) is an alternative measure of effective connectivity based on information theory...
  4. doi Transfer entropy in magnetoencephalographic data: quantifying information flow in cortical and cerebellar networks
    Michael Wibral
    Goethe University, Brain Imaging Center, MEG Unit, Heinrich Hoffmann Strasse 10, 60528 Frankfurt, Germany
    Prog Biophys Mol Biol 105:80-97. 2011
    ..Ideally, this method should not require a pre-specified model of the interaction. Transfer entropy--an information theoretic implementation of Wiener-type causality--is a method for the investigation of causal ..
  5. ncbi Granger causality and transfer entropy are equivalent for Gaussian variables
    Lionel Barnett
    Centre for Computational Neuroscience and Robotics, School of Informatics, University of Sussex, Brighton BN1 9QJ, United Kingdom
    Phys Rev Lett 103:238701. 2009
    ..More recently transfer entropy, an information-theoretic measure of time-directed information transfer between jointly dependent processes, has ..
  6. ncbi A two-entropies analysis to identify functional positions in the transmembrane region of class A G protein-coupled receptors
    Kai Ye
    Division of Medicinal Chemistry, Leiden Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands
    Proteins 63:1018-30. 2006
    ..Our method appears superior when compared to other bioinformatics approaches, such as the evolutionary trace method, entropy-variability plot, and correlated mutation analysis, both qualitatively and quantitatively.
  7. pmc Accommodation of aminoacyl-tRNA into the ribosome involves reversible excursions along multiple pathways
    Paul C Whitford
    Center for Theoretical Biological Physics and Department of Physics, University of California, San Diego, La Jolla, California 92093, USA
    RNA 16:1196-204. 2010
    ..that employ an all-atom, structure-based (Gō-like) model illuminate the interplay between configurational entropy and effective enthalpy during the accommodation process...
  8. pmc Entropy as the driver of chromosome segregation
    Suckjoon Jun
    FAS Center for Systems Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Nat Rev Microbiol 8:600-7. 2010
    ..as a result of entropic forces, despite their strong confinement within the cell; in other words, we propose that entropy can act as a primordial physical force which drives chromosome segregation under the right physical conditions...
  9. ncbi Prediction of G-protein-coupled receptor classes in low homology using Chou's pseudo amino acid composition with approximate entropy and hydrophobicity patterns
    Q Gu
    College of Information Sciences and Technology, Donghua University, Shanghai 201620, China
    Protein Pept Lett 17:559-67. 2010
    We use approximate entropy and hydrophobicity patterns to predict G-protein-coupled receptors. Adaboost classifier is adopted as the prediction engine. A low homology dataset is used to validate the proposed method...
  10. pmc Pairwise maximum entropy models for studying large biological systems: when they can work and when they can't
    Yasser Roudi
    Gatsby Computational Neuroscience Unit, University College London, London, United Kingdom
    PLoS Comput Biol 5:e1000380. 2009
    ..Applied to neural data, the size of most systems studied so far is below the crossover point...
  11. pmc QDMR: a quantitative method for identification of differentially methylated regions by entropy
    Yan Zhang
    College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China
    Nucleic Acids Res 39:e58. 2011
    ..to quantify methylation difference and identify DMRs from genome-wide methylation profiles by adapting Shannon entropy. QDMR was applied to synthetic methylation patterns and methylation profiles detected by methylated DNA ..
  12. pmc Protein flexibility and conformational entropy in ligand design targeting the carbohydrate recognition domain of galectin-3
    Carl Diehl
    Center for Molecular Protein Science, Biophysical Chemistry, Lund University, P O Box 124, SE 22100 Lund, Sweden
    J Am Chem Soc 132:14577-89. 2010
    ..Despite the fundamental importance of both enthalpy and entropy in driving ligand binding, the role of conformational entropy is rarely addressed in drug design...
  13. ncbi Information theory, novelty and hippocampal responses: unpredicted or unpredictable?
    Bryan A Strange
    Wellcome Department of Imaging Neuroscience, Functional Imaging Laboratory, Institute of Neurology, 12 Queen Square, London WC1N 3BG, UK
    Neural Netw 18:225-30. 2005
    ..In particular, entropy measures the expected uncertainty of events in a given context...
  14. ncbi Common input explains higher-order correlations and entropy in a simple model of neural population activity
    Jakob H Macke
    Gatsby Computational Neuroscience Unit, University College London, London, United Kingdom
    Phys Rev Lett 106:208102. 2011
    ..to large changes in higher-order redundancies, and that the resulting interactions have a strong impact on the entropy, sparsity, and statistical heat capacity of the population...
  15. pmc Analysis of kinetics using a hybrid maximum-entropy/nonlinear-least-squares method: application to protein folding
    Peter J Steinbach
    Center for Molecular Modeling, Center for Information Technology, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biophys J 82:2244-55. 2002
    A hybrid analysis that combines the maximum entropy method (MEM) with nonlinear least squares (NLS) fitting has been developed to interpret a general time-dependent signal...
  16. pmc Extending transfer entropy improves identification of effective connectivity in a spiking cortical network model
    Shinya Ito
    Department of Physics, Indiana University, Bloomington, Indiana, United States of America
    PLoS ONE 6:e27431. 2011
    Transfer entropy (TE) is an information-theoretic measure which has received recent attention in neuroscience for its potential to identify effective connectivity between neurons...
  17. ncbi Evaluating information transfer between auditory cortical neurons
    Boris Gourévitch
    Department of Physiology and Biophysics and Department of Psychology, University of Calgary, Calgary, Alberta, Canada
    J Neurophysiol 97:2533-43. 2007
    Transfer entropy, presented as a new tool for investigating neural assemblies, quantifies the fraction of information in a neuron found in the past history of another neuron. The asymmetry of the measure allows feedback evaluations...
  18. ncbi Predicting survival in heart failure case and control subjects by use of fully automated methods for deriving nonlinear and conventional indices of heart rate dynamics
    K K Ho
    Cardiovascular Division, Beth Israel Deaconess Medical Center, Boston, Mass 02215 5491, USA
    Circulation 96:842-8. 1997
    ..Despite much recent interest in quantification of heart rate variability (HRV), the prognostic value of conventional measures of HRV and of newer indices based on nonlinear dynamics is not universally accepted...
  19. ncbi Symbolic transfer entropy
    Matthäus Staniek
    Department of Epileptology, Neurophysics Group, University of Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    Phys Rev Lett 100:158101. 2008
    We propose to estimate transfer entropy using a technique of symbolization...
  20. pmc Entropy explains aging, genetic determinism explains longevity, and undefined terminology explains misunderstanding both
    Leonard Hayflick
    PLoS Genet 3:e220. 2007
  21. ncbi Conformational entropy in molecular recognition by proteins
    Kendra King Frederick
    Johnson Research Foundation and Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nature 448:325-9. 2007
    ..Historically it has been virtually impossible to experimentally estimate changes in protein conformational entropy, a potentially important component of the free energy of protein association...
  22. ncbi An entropy-based approach for testing genetic epistasis underlying complex diseases
    Guolian Kang
    Department of Statistics and Probability, East Lansing, Michigan State University, MI 48824, USA
    J Theor Biol 250:362-74. 2008
    ..In this article, we introduce a new approach for testing genetic epistasis in multiple loci using an entropy-based statistic for a case-only design. The entropy-based statistic asymptotically follows a chi(2) distribution...
  23. pmc Nonadditivity in conformational entropy upon molecular rigidification reveals a universal mechanism affecting folding cooperativity
    Oleg K Vorov
    Department of Physics and Optical Science, University of North Carolina at Charlotte, Charlotte, North Carolina, USA
    Biophys J 100:1129-38. 2011
    ..classical helix-coil transition theories, the folding mechanism derives from nonadditivity in conformational entropy caused by rigidification of molecular structure as intramolecular cross-linking interactions form along the ..
  24. doi Entropy-driven cAMP-dependent allosteric control of inhibitory interactions in exchange proteins directly activated by cAMP
    Rahul Das
    Department of Chemistry, Biochemistry, and Biomedical Sciences, McMaster University, Hamilton, Ontario L8S 4M1, Canada
    J Biol Chem 283:19691-703. 2008
    ....
  25. doi Assessment of non-invasive time and frequency atrial fibrillation organization markers with unipolar atrial electrograms
    Raul Alcaraz
    Innovation in Bioengineering Research Group, University of Castilla La Mancha, Campus Universitario, Cuenca, Spain
    Physiol Meas 32:99-114. 2011
    ..ECG and AEG signals, AF organization has been computed by applying a nonlinear regularity index, such as sample entropy (SampEn), to the atrial activity (AA) and to its fundamental waveform, defined as the main atrial wave (MAW)...
  26. pmc Connections between classical and parametric network entropies
    Matthias Dehmer
    Institute for Bioinformatics and Translational Research, UMIT, Hall in Tirol, Austria
    PLoS ONE 6:e15733. 2011
    ..The inequalities established in this paper relating classical and parametric measures lay a foundation for systematic classification of entropy-based measures of graph complexity.
  27. ncbi Evaluation of EEG localization methods using realistic simulations of interictal spikes
    C Grova
    Montreal Neurological Institute, McGill University, EEG Department, Room 009d, 3801 University Street, Montreal, Quebec, Canada H3A 2B4
    Neuroimage 29:734-53. 2006
    ..MSP), cortical LORETA with or without additional minimum norm regularization, and two derivations of the maximum entropy on the mean (MEM) approach...
  28. ncbi Maximum entropy: a complement to Tikhonov regularization for determination of pair distance distributions by pulsed ESR
    Yun Wei Chiang
    Baker Laboratory of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853 1301, USA
    J Magn Reson 177:184-96. 2005
    ..The Shannon-Jaynes entropy of a probability distribution provides an intrinsic non-negativity constraint on the probability distribution and ..
  29. pmc A comparison of pain level and entropy changes following core stability exercise intervention
    Taero Lee
    Department of Healthcare Management, College of Health Science, Korea University, Seoul, Republic of Korea
    Med Sci Monit 17:CR362-8. 2011
    ..We examined whether the observed Shannon (information) entropy, as compared with median frequency (MF), was able to differentiate fatigability of the thoracic and lumbar parts ..
  30. ncbi Spectral entropy measurement of patient responsiveness during propofol and remifentanil. A comparison with the bispectral index
    A L G Vanluchene
    Department of Anaesthesia, Gent University Hospital, De Pintelaan 185, B 9000 Gent, Belgium
    Br J Anaesth 93:645-54. 2004
    We compared two spectral entropies, state entropy (SE) and response entropy (RE), based on the irregularity of the EEG, to measure loss of response to verbal command (LOR(verbal)) and noxious stimulus (LOR(noxious)) with the bispectral ..
  31. doi Entropy-accelerated exact clustering of protein decoys
    Francois Berenger
    Zhang Initiative Research Unit, Advanced Science Institute, RIKEN, Wako, Saitama, Japan
    Bioinformatics 27:939-45. 2011
    ..Typically, only a reduced set of decoys using energy filtering is subjected to clustering analysis. A fast clustering method for a large decoy set would be beneficial to protein structure prediction and this still poses a challenge...
  32. doi Protein activity regulation by conformational entropy
    Shiou Ru Tzeng
    Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey 08854, USA
    Nature 488:236-40. 2012
    ..Here we show that changes in conformational entropy can determine whether protein-ligand interactions will occur, even among protein complexes with identical binding ..
  33. pmc Altered neural and behavioral dynamics in Huntington's disease: an entropy conservation approach
    S Lee Hong
    Department of Kinesiology, Indiana University, Bloomington, Indiana, United States of America
    PLoS ONE 7:e30879. 2012
    ..The aim of this study was to test the patterns of unpredictability in brain and behavior in wild-type (WT) and R6/2 mice...
  34. doi Accounting for conformational entropy in predicting binding free energies of protein-protein interactions
    Hetunandan Kamisetty
    Computer Science Department, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA
    Proteins 79:444-62. 2011
    ..often marginally stable, so one must examine the balance between the change in enthalpy, ΔH, and the change in entropy, ΔS, when investigating known complexes, characterizing the effects of mutations, or designing optimized ..
  35. doi Statistical analysis of the cancer cell's molecular entropy using high-throughput data
    Wessel N van Wieringen
    Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands
    Bioinformatics 27:556-63. 2011
    As cancer progresses, DNA copy number aberrations accumulate and the genomic entropy (chromosomal disorganization) increases...
  36. pmc Explaining the varied glycosidic conformational, G-tract length and sequence preferences for anti-parallel G-quadruplexes
    Xiaohui Cang
    Department of Medicinal Chemistry, College of Pharmacy, University of Utah, Salt Lake City, Utah, USA
    Nucleic Acids Res 39:4499-512. 2011
    ..This leads to smaller energy differences between different geometries and helps explain the extreme structural polymorphism of the human telomeric G-quadruplexes...
  37. pmc Maximum entropy models for antibody diversity
    Thierry Mora
    Joseph Henry Laboratories of Physics and Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    Proc Natl Acad Sci U S A 107:5405-10. 2010
    Recognition of pathogens relies on families of proteins showing great diversity. Here we construct maximum entropy models of the sequence repertoire, building on recent experiments that provide a nearly exhaustive sampling of the IgM ..
  38. pmc Gaining ligand selectivity in thyroid hormone receptors via entropy
    Leandro Martinez
    Instituto de Quimica, Universidade Estadual de Campinas, SP 13084 862, Campinas, Brazil
    Proc Natl Acad Sci U S A 106:20717-22. 2009
    ..Similar effects could potentially be exploited in nuclear receptor drug design...
  39. ncbi The concept of structural entropy in tissue-based diagnosis
    Klaus Kayser
    UICC Telepathology Consultation Center, Charite, Berlin, Germany
    Anal Quant Cytol Histol 29:296-308. 2007
    The concept of entropy is described and its characteristics discussed as applied in tissue-based diagnosis. The concept of entropy includes at least 2 points of view--thermodynamic and informatics perspectives...
  40. pmc Are protein-protein interfaces more conserved in sequence than the rest of the protein surface?
    Daniel R Caffrey
    Pfizer Discovery Technology Center, Cambridge, Massachusetts 02139, USA
    Protein Sci 13:190-202. 2004
    ....
  41. ncbi DNA binding of a non-sequence-specific HMG-D protein is entropy driven with a substantial non-electrostatic contribution
    Anatoly I Dragan
    Department of Biology, Johns Hopkins University, Mudd Hall, 3400 N Charles Street, Baltimore, MD 21218 2685, USA
    J Mol Biol 331:795-813. 2003
    ..e. DNA binding is a completely entropy-driven process...
  42. ncbi Weighted rank aggregation of cluster validation measures: a Monte Carlo cross-entropy approach
    Vasyl Pihur
    Department of Bioinformatics and Biostatistics, University of Louisville, Louisville, KY 40202, USA
    Bioinformatics 23:1607-15. 2007
    ..An automated and objective way of reconciling the rankings is needed...
  43. ncbi Comparative evaluation of the Datex-Ohmeda S/5 Entropy Module and the Bispectral Index monitor during propofol-remifentanil anesthesia
    Gunter N Schmidt
    Department of Anesthesiology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Anesthesiology 101:1283-90. 2004
    ..The Datex-Ohmeda S/5 Entropy Module (Datex-Ohmeda Division, Instrumentarium Corp...
  44. pmc A large scale analysis of information-theoretic network complexity measures using chemical structures
    Matthias Dehmer
    Institute for Bioinformatics and Translational Research, UMIT, Hall in Tyrol, Austria
    PLoS ONE 4:e8057. 2009
    ..Generally, a high uniqueness is an important and desirable property when designing novel topological descriptors having the potential to be applied to large chemical databases...
  45. pmc Potential landscape and flux framework of nonequilibrium networks: robustness, dissipation, and coherence of biochemical oscillations
    Jin Wang
    State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, People s Republic of China
    Proc Natl Acad Sci U S A 105:12271-6. 2008
    ..We also found that the entropy production of the whole network, characterizing the dissipation costs from the combined effects of both ..
  46. doi A maximum entropy model applied to spatial and temporal correlations from cortical networks in vitro
    Aonan Tang
    Department of Physics, Indiana University, Bloomington, Indiana 47405, USA
    J Neurosci 28:505-18. 2008
    ..To explain these correlated network states, two groups recently applied a second-order maximum entropy model that used only observed firing rates and pairwise interactions as parameters (Schneidman et al...
  47. ncbi Win some, lose some: enthalpy-entropy compensation in weak intermolecular interactions
    J D Dunitz
    Organic Chemistry Laboratory, Swiss Federal Institute of Technology, Zurich, Switzerland
    Chem Biol 2:709-12. 1995
    Enthalpy-entropy compensation is a general feature of many chemical reactions and processes in biological systems, but its origin has remained obscure...
  48. ncbi Nonclassical splicing mutations in the coding and noncoding regions of the ATM Gene: maximum entropy estimates of splice junction strengths
    Laura Eng
    Department of Pathology and Laboratory Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1732, USA
    Hum Mutat 23:67-76. 2004
    ..mutations in 12 A-T patients and compare cDNA changes to estimates of splice junction strengths based on maximum entropy modeling...
  49. ncbi Basin entropy in Boolean network ensembles
    Peter Krawitz
    Institute for Systems Biology, Seattle, Washington 98103, USA
    Phys Rev Lett 98:158701. 2007
    ..We introduce a novel network parameter, the basin entropy, as a measure of the complexity of information that such a system is capable of storing...
  50. pmc Experimental evidence for a frustrated energy landscape in a three-helix-bundle protein family
    Beth G Wensley
    Department of Chemistry, University of Cambridge, MRC Centre for Protein Engineering, Lensfield Rd, Cambridge CB2 1EW UK
    Nature 463:685-8. 2010
    ..Simple folding models show that folding is significantly influenced by chain entropy; proteins in which the contacts are local fold quickly, owing to the low entropy cost of forming stabilizing, ..
  51. pmc Entropy bounds for hierarchical molecular networks
    Matthias Dehmer
    Institute of Discrete Mathematics and Geometry, Vienna University of Technology, Vienna, Austria
    PLoS ONE 3:e3079. 2008
    In this paper we derive entropy bounds for hierarchical networks...
  52. pmc ROKU: a novel method for identification of tissue-specific genes
    Koji Kadota
    Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    BMC Bioinformatics 7:294. 2006
    ..One of the important goals of microarray research is the identification of genes whose expression is considerably higher or lower in some tissues than in others. We would like to have ways of identifying such tissue-specific genes...
  53. ncbi Human midbrain sensitivity to cognitive feedback and uncertainty during classification learning
    A R Aron
    Dept of Psychology and Brain Research Institute, University of California Los Angeles, CA 90065, USA
    J Neurophysiol 92:1144-52. 2004
    ..Purely cognitive feedback apparently engages the same regions as rewarding stimuli, consistent with a broader characterization of this network...
  54. doi Fast computation of sample entropy and approximate entropy in biomedicine
    Yu Hsiang Pan
    Department of Environmental Biology and Fisheries Science, National Taiwan Ocean University, 2 Pei Ning Road, Keelung 20224, Taiwan
    Comput Methods Programs Biomed 104:382-96. 2011
    Both sample entropy and approximate entropy are measurements of complexity...
  55. pmc Weak pairwise correlations imply strongly correlated network states in a neural population
    Elad Schneidman
    Joseph Henry Laboratories of Physics, Princeton University, Princeton, New Jersey 08544, USA
    Nature 440:1007-12. 2006
    ..These maximum entropy models are equivalent to Ising models, and predict that larger networks are completely dominated by correlation ..
  56. doi Non-stationarities significantly distort short-term spectral, symbolic and entropy heart rate variability indices
    Valentina Magagnin
    Laboratorio di Modellistica di Sistemi Complessi, Dipartimento di Tecnologie per la Salute, Istituto Ortopedico Galeazzi, Universita degli Studi di Milano, Via R Galeazzi 4, Milan, Italy
    Physiol Meas 32:1775-86. 2011
    ..The aim of our study is to quantify the potential bias of spectral, symbolic and entropy HRV indices due to non-stationarities...
  57. ncbi Structural and thermodynamic strategies for site-specific DNA binding proteins
    L Jen-Jacobson
    Department of Biological Sciences University of Pittsburgh, Pittsburgh, PA 15260, USA
    Structure 8:1015-23. 2000
    ..A better understanding of the structural and energetic engineering principles might lead to rational methods for modification or design of such proteins...
  58. ncbi Prediction of spatiotemporal patterns of neural activity from pairwise correlations
    O Marre
    Unité de neurosciences intégratives et computationnelles UNIC, UPR CNRS 2191, Gif sur Yvette, France
    Phys Rev Lett 102:138101. 2009
    ..Using a maximum entropy principle with a Markovian assumption, we obtain a model that accounts for both spatial and temporal pairwise ..
  59. pmc Nonequilibrium generation of information in copolymerization processes
    David Andrieux
    Center for Nonlinear Phenomena and Complex Systems, Universite Libre de Bruxelles, Code Postal 231, Campus Plaine, B 1050 Brussels, Belgium
    Proc Natl Acad Sci U S A 105:9516-21. 2008
    ..This shows in particular how information acquisition results from the interplay between stored patterns and dynamical evolution in nonequilibrium environments. In addition, we apply these results to the process of DNA replication...
  60. pmc Apomorphine reduces subthalamic neuronal entropy in parkinsonian patients
    M Lafreniere-Roula
    Department of Physiology, University of Toronto, Toronto, ON, M5S 1A8, Canada
    Exp Neurol 225:455-8. 2010
    ..Here we examine the entropy of subthalamic neurons in PD patients undergoing stereotactic surgery for deep brain stimulation (DBS)...
  61. pmc A thermodynamic approach to the affinity optimization of drug candidates
    Ernesto Freire
    Department of Biology, The Johns Hopkins University, Baltimore, MD 21218, USA
    Chem Biol Drug Des 74:468-72. 2009
    ..As the binding affinity is a function of two quantities, the binding enthalpy and the binding entropy, it is evident that a more efficient optimization would be accomplished if both quantities were considered and ..
  62. ncbi Generalized scalar measures for diffusion MRI using trace, variance, and entropy
    Evren Ozarslan
    Department of Physics, University of Florida, P O Box 118440, Gainesville, FL 32611, USA
    Magn Reson Med 53:866-76. 2005
    ..Simulations suggested that a lower-rank tensor model may produce artificially low anisotropy values in voxels with complex structure. This was confirmed with a spin-echo experiment performed on an excised rat brain...
  63. ncbi Maximum-entropy closures for kinetic theories of neuronal network dynamics
    Aaditya V Rangan
    Courant Institute of Mathematical Sciences, New York University, New York 10012, USA
    Phys Rev Lett 96:178101. 2006
    ..We demonstrate that this intuitive closure is a generalization of moment closures based on the maximum-entropy principle...
  64. ncbi A comparison of state and response entropy versus bispectral index values during the perioperative period
    Paul F White
    Department of Anesthesiology and Pain Management, University of Texas, Southwestern Medical Center at Dallas, Texas 75390 9068, USA
    Anesth Analg 102:160-7. 2006
    ..We designed this clinical study to test the hypothesis that use of the spectral entropy (Entropy) module is associated with less frequent intraoperative interference with the displayed indices than the ..
  65. doi Conformational constraint in protein ligand design and the inconsistency of binding entropy
    D Gomika Udugamasooriya
    Department of Chemistry, Wayne State University, Detroit, MI 48202, USA
    Biopolymers 89:653-67. 2008
    ..expectation of improving affinity, justified by the theoretical possibility that an unfavorable change in binding entropy will be reduced...
  66. pmc Association entropy in adsorption processes
    N Ben-Tal
    Department of Biochemistry, George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv 69978, Israel
    Biophys J 79:1180-7. 2000
    ..g., the binding of a ligand to a protein or the adsorption of a peptide on a lipid membrane, involves an entropy loss, reflecting the conversion of free translational and rotational degrees of freedom into bound motions...
  67. doi Atypical EEG complexity in autism spectrum conditions: a multiscale entropy analysis
    Ana Catarino
    Institute of Biophysics and Biomedical Engineering, Faculty of Sciences, University of Lisbon, Campo Grande 1749 016 Lisbon, Portugal
    Clin Neurophysiol 122:2375-83. 2011
    ..One recently developed measure of intrinsic complexity of biological systems is multiscale entropy (MSE)...
  68. pmc Quantifying selection and diversity in viruses by entropy methods, with application to the haemagglutinin of H3N2 influenza
    Keyao Pan
    Department of Bioengineering, Rice University, 6100 Main Street, Houston, TX 77005, USA
    J R Soc Interface 8:1644-53. 2011
    ..In this paper, we use Shannon entropy and relative entropy to measure the diversity and selection pressure by an antibody in each amino acid site of H3 ..
  69. ncbi Efficiency, power, and entropy in event-related fMRI with multiple trial types. Part II: design of experiments
    Thomas T Liu
    Center for Functional Magnetic Resonance Imaging, University of California San Diego, La Jolla, CA, USA
    Neuroimage 21:401-13. 2004
    ..the hemodynamic response, its detection power, which is the ability to detect an activation, and its conditional entropy, which is a measure of the randomness of the design...
  70. pmc Tensile forces and shape entropy explain observed crista structure in mitochondria
    M Ghochani
    Department of Physics, San Diego State University, San Diego, CA, USA
    Biophys J 99:3244-54. 2010
    ..The model also predicts a pressure difference of -0.036 ± 0.004 atm (pressure higher in the matrix) and a surface tension equal to 0.09 ± 0.04 pN/nm...
  71. doi Accurate estimation of entropy in very short physiological time series: the problem of atrial fibrillation detection in implanted ventricular devices
    Douglas E Lake
    Cardiovascular Division, Department of Internal Medicine, and Cardiovascular Research Center, University of Virginia Health System, Charlottesville, Virginia, USA
    Am J Physiol Heart Circ Physiol 300:H319-25. 2011
    b>Entropy estimation is useful but difficult in short time series...
  72. pmc Repulsive forces between looping chromosomes induce entropy-driven segregation
    Manfred Bohn
    Institute for Theoretical Physics, Heidelberg University, Heidelberg, Germany
    PLoS ONE 6:e14428. 2011
    ..Our results suggest that the formation of chromatin loops imposes both compartmentalization as well as order on the system without requiring additional energy-consuming processes...
  73. pmc Computing the conformational entropy for RNA folds
    Liang Liu
    Department of Physics and Astronomy, University of Missouri, Columbia, Missouri 65211, USA
    J Chem Phys 132:235104. 2010
    We develop a polymer physics-based method to compute the conformational entropy for RNA tertiary folds, namely, conformations consisting of multiple helices connected through (cross-linked) loops...
  74. ncbi Approximate entropy of self-reported mood prior to episodes in bipolar disorder
    Tasha Glenn
    ChronoRecord Association, Inc, Fullerton, CA 92834, USA
    Bipolar Disord 8:424-9. 2006
    Approximate entropy (ApEn) measures regularity in time series data, while traditional linear statistics measure variability...
  75. ncbi Entropy, entropy rate, and pattern classification as tools to typify complexity in short heart period variability series
    A Porta
    Dipartimento di Scienze Precliniche, Universita degli Studi di Milano, LITA di Vialba, Italy
    IEEE Trans Biomed Eng 48:1282-91. 2001
    ..The approach relies on: 1) the calculation of Shannon entropy (SE) of the distribution of patterns lasting three beats; 2) the calculation of a regularity index based on an ..
  76. pmc Neural decision boundaries for maximal information transmission
    Tatyana Sharpee
    Crick Jacobs Center for Theoretical Biology and Laboratory of Computational Neurobiology, Salk Institute for Biological Studies, La Jolla, California, United States of America
    PLoS ONE 2:e646. 2007
    ..As an example, we consider exponentially distributed inputs, which are known to approximate a variety of signals from natural environment...
  77. pmc Approximate entropy detects the effect of a secondary cognitive task on postural control in healthy young adults: a methodological report
    James T Cavanaugh
    Department of Physical Therapy, University of New England, Portland, ME, USA
    J Neuroeng Rehabil 4:42. 2007
    ..Approximate entropy (ApEn), a regularity statistic from nonlinear dynamics, recently has demonstrated relatively good measurement ..
  78. ncbi Importance of entropy in the conformational equilibrium of phenylalanine: a matrix-isolation infrared spectroscopy and density functional theory study
    A Kaczor
    Department of Chemistry, University of Coimbra, P 3004 535 Coimbra, Portugal
    J Phys Chem A 110:2360-70. 2006
    ..Being considerably more flexible, type II conformers are stabilized by entropy and the relative abundances of two conformers of this type (IIb(2) and IIc(1)) are shown to significantly ..
  79. ncbi RR interval dynamics before atrial fibrillation in patients after coronary artery bypass graft surgery
    C W Hogue
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Circulation 98:429-34. 1998
    ..Because nonlinear methods of HRV analysis provide information about heart rate dynamics not evident from usual HRV measures, we also hypothesized that approximate entropy (ApEn), a nonlinear measure of HRV, might have predictive value.
  80. ncbi Sequence analysis reveals how G protein-coupled receptors transduce the signal to the G protein
    Laerte Oliveira
    Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
    Proteins 52:553-60. 2003
    Sequence entropy-variability plots based on alignments of very large numbers of sequences-can indicate the location in proteins of the main active site and modulator sites...
  81. pmc A synergistic approach to protein crystallization: combination of a fixed-arm carrier with surface entropy reduction
    Andrea F Moon
    Laboratory of Structural Biology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Protein Sci 19:901-13. 2010
    ..such obstacles: crystallization using carrier proteins or antibody complexes, chemical modification, surface entropy reduction, proteolytic digestion, and additive screening...
  82. doi Genetics vs. entropy: longevity factors suppress the NF-kappaB-driven entropic aging process
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Ageing Res Rev 9:298-314. 2010
    ..This age-related increase in cellular entropy is compatible with the disposable soma theory of aging...
  83. pmc Bipartite pattern discovery by entropy minimization-based multiple local alignment
    Chengpeng Bi
    Laboratory of Human Molecular Genetics, Children s Mercy Hospital and Clinics, 2401 Gillham Road, Kansas City, MO 64108, USA
    Nucleic Acids Res 32:4979-91. 2004
    ..pattern discovery (Bipad), which produces a mathematical model based on information maximization or Shannon's entropy minimization principle, for discovery of bipartite sequence patterns...
  84. pmc Quantitative measurement of aging using image texture entropy
    Lior Shamir
    Laboratory of Genetics, National Institute on Aging NIH, 251 Bayview Boulevard, Baltimore, MD 21224, USA
    Bioinformatics 25:3060-3. 2009
    ..Here we propose to use the image texture entropy as an objective measurement that reflects the structural deterioration of the C...
  85. ncbi Estimating the entropy rate of spike trains via Lempel-Ziv complexity
    José M Amigó
    Centro de Investigación Operativa, Universidad Miguel Hernandez, 03202 Elche, Spain
    Neural Comput 16:717-36. 2004
    ..rate of new patterns along a digital sequence, is closely related to such important source properties as entropy and compression ratio, but, in contrast to these, it is a property of individual sequences...
  86. pmc Ligand configurational entropy and protein binding
    Chia en A Chang
    Department of Chemistry and Biochemistry, and Center for Theoretical Biological Physics, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 104:1534-9. 2007
    The restriction of a small molecule's motion on binding to a protein causes a loss of configurational entropy, and thus a penalty in binding affinity...
  87. pmc Regularity of center-of-pressure trajectories depends on the amount of attention invested in postural control
    Stella F Donker
    Faculty of Human Movement Sciences, VU University, Research Institute MOVE, Van der Boechorststraat 9, 1081 BT, Amsterdam, The Netherlands
    Exp Brain Res 181:1-11. 2007
    ..We quantified COP dynamics in terms of sample entropy (regularity), standard deviation (variability), sway-path length of the normalized posturogram (curviness), ..
  88. doi On entropy-based molecular descriptors: statistical analysis of real and synthetic chemical structures
    Matthias Dehmer
    Institute for Bioinformatics and Translational Research, UMIT, Eduard Wallnoefer Zentrum 1, A 6060, Hall in Tyrol, Austria
    J Chem Inf Model 49:1655-63. 2009
    This paper presents an analysis of entropy-based molecular descriptors...
  89. ncbi Direct evaluation of a kinetic model for RecA-mediated DNA-strand exchange: the importance of nucleic acid dynamics and entropy during homologous genetic recombination
    Jie Xiao
    Department of Biochemistry and Cell Biology, Rice University, Houston, TX 77251 1892, USA
    Chembiochem 7:1265-78. 2006
    ..The data best support the conclusion that the mechanistic strategy of RecA likely relies on intrinsic DNA dynamics...
  90. ncbi Conditional entropy approach for the evaluation of the coupling strength
    A Porta
    Dipartimento di Scienze Precliniche, Universita degli Studi di Milano, Italy
    Biol Cybern 81:119-29. 1999
    ..The method is based on the definition of an uncoupling function calculating, by means of entropy rates, the minimum amount of independent information (i.e...
  91. doi An entropy-based approach for the identification of phylogenetically informative genomic regions of Papillomavirus
    Marcus V A Batista
    Department of Genetics, Center for Biological Sciences, Federal University of Pernambuco, 50670 901 Recife, Pernambuco, Brazil
    Infect Genet Evol 11:2026-33. 2011
    ..This study aimed at making use of a novel approach based on entropy to select suitable genomic regions from which to infer the phylogeny of papillomavirus...
  92. pmc Information generated by the moving pinnae of Rhinolophus rouxi: tuning of the morphology at different harmonics
    Dieter Vanderelst
    Department MTT FTEW, Active Perception Lab, University Antwerp, Antwerp, Belgium
    PLoS ONE 6:e20627. 2011
    ....
  93. pmc Assessment of EEG dynamical complexity in Alzheimer's disease using multiscale entropy
    Tomoyuki Mizuno
    Department of Neuropsychiatry, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
    Clin Neurophysiol 121:1438-46. 2010
    Multiscale entropy (MSE) is a recently proposed entropy-based index of physiological complexity, evaluating signals at multiple temporal scales...
  94. pmc Nonlinear analysis of motor activity shows differences between schizophrenia and depression: a study using Fourier analysis and sample entropy
    Erik R Hauge
    Olaviken Psychiatric Hospital, Bergen, Norway
    PLoS ONE 6:e16291. 2011
    ..The sample entropy was higher in the schizophrenic patients compared to controls in the time series from the activity counts made ..
  95. doi Measuring fluid intelligence on a ratio scale: evidence from nonverbal classification problems and information entropy
    Philippe E Ruiz
    ESC Lille Graduate School LSMRC, Euralille, France
    Behav Res Methods 41:439-45. 2009
    ..literatures, the relationship between the four subtests of the Culture-Fair Intelligence Test (CFIT) and the entropy of the Ruiz Absolute Scale of Complexity Management (R-ASCM) was investigated...
  96. pmc Using entropy maximization to understand the determinants of structural dynamics beyond native contact topology
    Timothy R Lezon
    Department of Computational Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS Comput Biol 6:e1000816. 2010
    ..A systematic study of a large set of NMR-determined proteins is analyzed using a novel method based on entropy maximization to demonstrate that the next level of refinement in the elastic network model description of ..
  97. doi Predicting embryonic patterning using mutual entropy fitness and in silico evolution
    Paul Francois
    Center for Studies in Physics and Biology, The Rockefeller University, 1230 York Avenue, 10065 New York, NY, USA
    Development 137:2385-95. 2010
    ..In silico evolution provides a quantitative demonstration that continuous positive selection can generate complex phenotypes from simple components by incremental evolution, as Darwin proposed...
  98. pmc Inference of gene regulatory networks from time series by Tsallis entropy
    Fabrício Martins Lopes
    Federal University of Technology Parana, Brazil
    BMC Syst Biol 5:61. 2011
    ..In order to improve the accuracy of GRNs inference methods based on entropy (mutual information), a new criterion function is here proposed.
  99. doi Shannon's entropy and fractal dimension provide an objective account of bone tissue organization during calvarial bone regeneration
    Lenaldo B Rocha
    Faculty of Medicine of Ribeirao Preto USP, Department of Pathology, 3900 Ribeirao Preto, SP, Brazil
    Microsc Res Tech 71:619-25. 2008
    ..In this study, we demonstrated the use of two distinct methods of image texture analysis, the Shannon's entropy [standard error (SE)], and the fractal dimension (FD) to characterize the formation and remodeling of newly ..
  100. doi Assessing aortic stenosis using sample entropy of the phonocardiographic signal in dogs
    C Ahlstrom Ast
    Department of Biomedical Engineering, Linkoping University, SE 581 83 Linkoping, Sweden
    IEEE Trans Biomed Eng 55:2107-9. 2008
    ..In this study, sample entropy (SampEn) was investigated as a measure of complexity using a dog model...
  101. doi Entropy drives integrin alphaIIbbeta3:echistatin binding--evidence from surface plasmon resonance spectroscopy
    Roy R Hantgan
    Department of Biochemistry, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157 1016, USA
    Biochemistry 47:2884-92. 2008
    ..K d data yielded an unfavorable enthalpy change, Delta H degrees = 14 +/- 3 kcal/mol, offset by a favorable entropy term, TDelta S degrees = 23 +/- 3 kcal/mol...

Research Grants72

  1. Mechanical Stress and the Heat-Treatment of Soft Tissue
    JAY HUMPHREY; Fiscal Year: 2003
    ..This reveals that loading influences the process via the activation entropy, not energy. No prior clinical trial of a heating device or strategy has accounted for this coupling...
  2. Consequences of Cardiac Arrest: Brain Injury
    NITISH VYOMESH THAKOR; Fiscal Year: 2010
    ..of cortical somatosensory evoked potentials (SSEP) will track recovery of normal thalamocortical coupling, and c) entropy-based quantitative EEG (qEEG) analysis will capture sequential changes in thalamocortical coupling during ..
  3. Mechanisms of Viral DNA Packaging
    CARLOS JOSE BUSTAMANTE; Fiscal Year: 2010
    ..density-overcoming energetic penalties due to electrostatics repulsion, DNA bending stiffness, and entropy. Because this motor is comprised of a pentameric ring of ASCE ATPases, its study will shed important light into ..
  4. MOLECULAR RECOGNITION IN THE STREPTAVIDIN BIOTIN SYSTEM
    Patrick Stayton; Fiscal Year: 2002
    ..interact with? For example, do residues contacting portions of a ligand expected to have high configurational entropy (such as the valeric acid tails of biotin) have a different energetic challenge than those residues contacting ..
  5. PROTEIN STABILITY IN HUMAN RHINOVIRUS
    CAROL POST; Fiscal Year: 2005
    ..As well as the mean thermodynamic properties enthalpy and entropy, fluctuation properties such as heat capacity and compressibility are useful for understanding contributions to ..
  6. Topoisomerases and Chromosome Segregation
    KENNETH MARIANS; Fiscal Year: 2009
    ..transertion (the coupling of transcription and co-translational insertion of proteins into the membrane], and entropy. And the role of the recently discovered MreB cytoskeleton remains unclear...
  7. Topoisomerases and Chromosome Segregation
    Kenneth J Marians; Fiscal Year: 2010
    ..transertion (the coupling of transcription and co-translational insertion of proteins into the membrane], and entropy. And the role of the recently discovered MreB cytoskeleton remains unclear...
  8. Topoisomerases and Chromosome Segregation
    Kenneth J Marians; Fiscal Year: 2010
    ..transertion (the coupling of transcription and co-translational insertion of proteins into the membrane], and entropy. And the role of the recently discovered MreB cytoskeleton remains unclear...
  9. Mechanisms of Allosteric Influence on Enzymes Activity
    GREGORY DUNCAN REINHART; Fiscal Year: 2010
    ..The second question is whether the entropy change that contributes to the action of an allosteric ligand is related to changes in enzyme dynamics...
  10. Mechanisms of Allosteric Influence on Enzymes Activity
    GREGORY DUNCAN REINHART; Fiscal Year: 2011
    ..The second question is whether the entropy change that contributes to the action of an allosteric ligand is related to changes in enzyme dynamics...
  11. Physiology & Measurement of Vocal Fold Vibration
    Jack Jiang; Fiscal Year: 2009
    ..Temporal instability and spatial variance will be measured using spatial correlation analysis and global entropy. Spatiotemporal analysis of high-speed imaging data will be further applied to study vibratory characteristics of ..
  12. Physiology & Measurement of Vocal Fold Vibration
    Jack Jiang; Fiscal Year: 2007
    ..Temporal instability and spatial variance will be measured using spatial correlation analysis and global entropy. Spatiotemporal analysis of high-speed imaging data will be further applied to study vibratory characteristics of ..
  13. Physiology & Measurement of Vocal Fold Vibration
    Jack J Jiang; Fiscal Year: 2010
    ..Temporal instability and spatial variance will be measured using spatial correlation analysis and global entropy. Spatiotemporal analysis of high-speed imaging data will be further applied to study vibratory characteristics of ..
  14. STRUCTURE PREDICTION OF PEPTIDES VIA GLOBAL OPTIMIZATION
    CHRISTODOULOS FLOUDAS; Fiscal Year: 1999
    ..pentapeptides of Met- enkephalin and Leu-enkephalin in the presence of water, (iii) calculations of the relative entropy and relative free energy, and (iv) constrained peptide systems...
  15. MECHANISM OF ENZYME MEDIATED ACTIVATION OF COENZYME B12
    Kenneth Brown; Fiscal Year: 1999
    ..of the extent to which the enzyme catalyzes the reaction by lowering the enthalpy and/or by raising the entropy of activation...
  16. NEURONAL BASIS UNDERLYING VOLATILE ANESTHETIC INDUCED HYPNOSIS
    MAX KELZ; Fiscal Year: 2010
    ..of VLPO cause resistance to anesthetic hypnosis as determined by righting reflex assays and processed EEG entropy. Finally, we will determine if light-induced depolarization of VLPO causes hypersensitivity to anesthetic ..
  17. Mechanisms of Viral DNA Packaging
    Carlos Bustamante; Fiscal Year: 2007
    ..density--overcoming energetic penalties due to electrostatic repulsion, DNA bending stiffness, and entropy. A single molecule optical tweezers assay has enabled real time measurement of phage phi29 packaging and shows ..
  18. POLYAMINE-POLYNUCLEOTIDE INTERACTIONS
    VICTOR BLOOMFIELD; Fiscal Year: 1980
    ..interactions, by using equilibrium dialysis in Hummel-Dreyer chromatography to measure free energy, enthalpy, and entropy of binding of putrescine, spermidine, spermine, and analogs of these as functions of ionic strength. 2...
  19. Signaling Proteins: Binding Studies and Peptide Mimetics
    Mark Spaller; Fiscal Year: 2006
    ..calorimetry (ITC), a powerful method that provides a thorough thermodynamic profile for binding (enthalpy, entropy, free energy, and dissociation constants)...
  20. Signaling Proteins: Binding Studies and Peptide Mimetics
    Mark Spaller; Fiscal Year: 2006
    ..calorimetry (ITC), a powerful method that provides a thorough thermodynamic profile for binding (enthalpy, entropy, free energy, and dissociation constants)...