porosity

Summary

Summary: Condition of having pores or open spaces. This often refers to bones, bone implants, or bone cements, but can refer to the porous state of any solid substance.

Top Publications

  1. ncbi Porosity of 3D biomaterial scaffolds and osteogenesis
    Vassilis Karageorgiou
    Department of Chemical and Biological Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, USA
    Biomaterials 26:5474-91. 2005
  2. doi The use of bone-graft substitutes in large bone defects: any specific needs?
    G M Calori
    COR, Orthopaedic Institute, G Pini, University of Milan, Italy
    Injury 42:S56-63. 2011
  3. ncbi Mesoporous silica nanoparticles for intracellular delivery of membrane-impermeable proteins
    Igor I Slowing
    Department of Chemistry, U S DOE Ames Laboratory, Iowa State University, Ames, Iowa 50011 3111, USA
    J Am Chem Soc 129:8845-9. 2007
  4. ncbi Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering
    K Rezwan
    Department of Materials, Imperial College London, Prince Consort Road, London SW7 2BP, UK
    Biomaterials 27:3413-31. 2006
  5. pmc Cell colonization in degradable 3D porous matrices
    Benjamin J Lawrence
    School of Chemical Engineering, Oklahoma State University, Stillwater, Oklahoma 74078, USA
    Cell Adh Migr 2:9-16. 2008
  6. ncbi Porous scaffold design for tissue engineering
    Scott J Hollister
    Scaffold Tissue Engineering Group, Department of Biomedical Engineering, The University of Michigan, Ann Arbor, Michigan 41809, USA
    Nat Mater 4:518-24. 2005
  7. ncbi Fabrication methods of porous metals for use in orthopaedic applications
    Garrett Ryan
    National University of Ireland, Department of Mechanical and Biomedical Engineering, Nun s Island, Galway, Ireland
    Biomaterials 27:2651-70. 2006
  8. doi Ultrahigh porosity in metal-organic frameworks
    Hiroyasu Furukawa
    Center for Reticular Chemistry at the California NanoSystems Institute, and Department of Chemistry and Biochemistry, University of California Los Angeles UCLA, 607 Charles E Young Drive East, Los Angeles, CA 90095, USA
    Science 329:424-8. 2010
  9. doi Intracortical remodelling and porosity in the distal radius and post-mortem femurs of women: a cross-sectional study
    Roger M D Zebaze
    Department of Medicine, Austin Health, University of Melbourne, Melbourne, Vic, Australia
    Lancet 375:1729-36. 2010
  10. ncbi Mesoporous silica nanoparticles as a delivery system for hydrophobic anticancer drugs
    Jie Lu
    Department of Microbiology, Immunology, and Molecular Genetics, California NanoSystems Institute, JCCC, University of California, Los Angeles, 609 Charles E Young Drive East, Los Angeles, CA 90095, USA
    Small 3:1341-6. 2007

Research Grants

Detail Information

Publications267 found, 100 shown here

  1. ncbi Porosity of 3D biomaterial scaffolds and osteogenesis
    Vassilis Karageorgiou
    Department of Chemical and Biological Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, USA
    Biomaterials 26:5474-91. 2005
    b>Porosity and pore size of biomaterial scaffolds play a critical role in bone formation in vitro and in vivo...
  2. doi The use of bone-graft substitutes in large bone defects: any specific needs?
    G M Calori
    COR, Orthopaedic Institute, G Pini, University of Milan, Italy
    Injury 42:S56-63. 2011
    ..The purpose of this study was to evaluate the type of materials used and their efficacy for the treatment of large bone defects in traumatology and orthopaedic surgery...
  3. ncbi Mesoporous silica nanoparticles for intracellular delivery of membrane-impermeable proteins
    Igor I Slowing
    Department of Chemistry, U S DOE Ames Laboratory, Iowa State University, Ames, Iowa 50011 3111, USA
    J Am Chem Soc 129:8845-9. 2007
    ....
  4. ncbi Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering
    K Rezwan
    Department of Materials, Imperial College London, Prince Consort Road, London SW7 2BP, UK
    Biomaterials 27:3413-31. 2006
    ....
  5. pmc Cell colonization in degradable 3D porous matrices
    Benjamin J Lawrence
    School of Chemical Engineering, Oklahoma State University, Stillwater, Oklahoma 74078, USA
    Cell Adh Migr 2:9-16. 2008
    ..Further, specific scaffold properties such as porosity, pore size, fiber thickness, topography and scaffold stiffness as well as important cell material interactions ..
  6. ncbi Porous scaffold design for tissue engineering
    Scott J Hollister
    Scaffold Tissue Engineering Group, Department of Biomedical Engineering, The University of Michigan, Ann Arbor, Michigan 41809, USA
    Nat Mater 4:518-24. 2005
    ....
  7. ncbi Fabrication methods of porous metals for use in orthopaedic applications
    Garrett Ryan
    National University of Ireland, Department of Mechanical and Biomedical Engineering, Nun s Island, Galway, Ireland
    Biomaterials 27:2651-70. 2006
    ..Another potentially valuable property of porous materials is their low elastic modulus. Depending on the porosity, moduli can even be tailored to match the modulus of bone closer than solid metals can, thus reducing the ..
  8. doi Ultrahigh porosity in metal-organic frameworks
    Hiroyasu Furukawa
    Center for Reticular Chemistry at the California NanoSystems Institute, and Department of Chemistry and Biochemistry, University of California Los Angeles UCLA, 607 Charles E Young Drive East, Los Angeles, CA 90095, USA
    Science 329:424-8. 2010
    ..The volume-specific internal surface area of MOF-210 (2060 square meters per cubic centimeter) is equivalent to the outer surface of nanoparticles (3-nanometer cubes) and near the ultimate adsorption limit for solid materials...
  9. doi Intracortical remodelling and porosity in the distal radius and post-mortem femurs of women: a cross-sectional study
    Roger M D Zebaze
    Department of Medicine, Austin Health, University of Melbourne, Melbourne, Vic, Australia
    Lancet 375:1729-36. 2010
    ..We aimed to re-examine cortical bone as a source of bone loss in the appendicular skeleton...
  10. ncbi Mesoporous silica nanoparticles as a delivery system for hydrophobic anticancer drugs
    Jie Lu
    Department of Microbiology, Immunology, and Molecular Genetics, California NanoSystems Institute, JCCC, University of California, Los Angeles, 609 Charles E Young Drive East, Los Angeles, CA 90095, USA
    Small 3:1341-6. 2007
  11. ncbi Ordered porous materials for emerging applications
    Mark E Davis
    Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA
    Nature 417:813-21. 2002
    ..In fact, porous materials now seem set to contribute to developments in areas ranging from microelectronics to medical diagnosis...
  12. doi Mesoporous silica as a membrane for ultra-thin implantable direct glucose fuel cells
    Tushar Sharma
    Department of Biomedical Engineering, University of Texas at Austin, Austin, TX 78712, USA
    Lab Chip 11:2460-5. 2011
    ..We demonstrate that a mesoporous silica thin film (270 nm) is capable of replacing the conventional polymer based membranes with an improvement in the power generated over conventional direct glucose fuel cells...
  13. pmc Mesoporous silica nanoparticles as drug delivery systems for targeted inhibition of Notch signaling in cancer
    Veronika Mamaeva
    Turku Centre for Biotechnology, University of Turku and Abo Akademi University, Turku, Finland
    Mol Ther 19:1538-46. 2011
    ..The data highlights MSNPs as an attractive platform for targeted drug delivery of anticancer drugs with otherwise restricted clinical application, and as interesting constituents in the quest for more refined Notch therapies...
  14. doi Highly porous large poly(lactic-co-glycolic acid) microspheres adsorbed with palmityl-acylated exendin-4 as a long-acting inhalation system for treating diabetes
    Hyunuk Kim
    College of Pharmacy, Pusan National University, Jangjun dong, Geumjeong Gu, Busan 609 735, Republic of Korea
    Biomaterials 32:1685-93. 2011
    ..We consider that this new prototype of porous PLGA MS has considerable pharmaceutical potential as a type 2 anti-diabetic inhalation treatment...
  15. doi Mesoporous silica nanoparticles for intracellular controlled drug delivery
    Juan L Vivero-Escoto
    Department of Chemistry and U S Department of Energy, Ames Laboratory, Iowa State University, Ames, IA 50011 3111, USA
    Small 6:1952-67. 2010
    ..Finally, the latest breakthroughs for intracellular controlled drug release using stimuli-responsive mesoporous-silica-based systems are described...
  16. doi Preparation and characterization of bioactive mesoporous wollastonite - Polycaprolactone composite scaffold
    Jie Wei
    Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, PR China
    Biomaterials 30:1080-8. 2009
    ..Such improved properties of m-WPC should be helpful for developing new biomaterials and may have potential use in hard tissue repair...
  17. pmc Structure of transmembrane pore induced by Bax-derived peptide: evidence for lipidic pores
    Shuo Qian
    Department of Physics and Astronomy, Rice University, Houston, TX 77251, USA
    Proc Natl Acad Sci U S A 105:17379-83. 2008
    ..Evidence suggests that the formation of such lipidic pores is a major mechanism for alpha-pore-forming proteins, including apoptosis-regulator Bax...
  18. ncbi Strength, fracture toughness and microstructure of a selection of all-ceramic materials. Part II. Zirconia-based dental ceramics
    Massimiliano Guazzato
    Biomaterials Science Research Unit, Faculty of Dentistry, University of Sydney, United Dental Hospital, 2 Chalmers Street, Surry Hills, NSW, Australia 2010
    Dent Mater 20:449-56. 2004
    ..In the present study, DC Zirkon, an experimental yttria partially stabilized zirconia, In-Ceram Zirconia slip and In-Ceram Zirconia dry-pressed were compared...
  19. doi Improvement of porous beta-TCP scaffolds with rhBMP-2 chitosan carrier film for bone tissue application
    Ander Abarrategi
    Instituto de Estudios Biofuncionales, Universidad Complutense, Madrid, Spain
    Tissue Eng Part A 14:1305-19. 2008
    ..Initial beta-TCP disks with an average diameter of 5.78 mm, 2.9 mm thickness, and 53% porosity were coated with a chitosan film...
  20. ncbi Structure and properties of bilayer chitosan-gelatin scaffolds
    Jin Shu Mao
    Research Institute of Polymeric Materials, Tianjin University, Tianjin 300072, China
    Biomaterials 24:1067-74. 2003
    ..These results suggested that the porosity and pore size of the scaffolds could be modulated with thermodynamic and kinetic parameters of ice formation...
  21. ncbi Mesoporous materials for drug delivery
    María Vallet-Regí
    Departamento de Quimica Inorganica y Bioinorganica, Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain
    Angew Chem Int Ed Engl 46:7548-58. 2007
    ..This Minireview deals with the advances in this field by the control of the textural parameters, surface functionalization, and the synthesis of sophisticated stimuli-response systems...
  22. ncbi Low stiffness porous Ti structures for load-bearing implants
    B Vamsi Krishna
    W M Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164 2920, USA
    Acta Biomater 3:997-1006. 2007
    ..to reduce effective stiffness for load-bearing implants. Young's modulus and 0.2% proof strength of these porous Ti samples having 35-42vol.% porosity are found to be similar to those of human cortical bone.
  23. ncbi Tissue ingrowth and degradation of two biodegradable porous polymers with different porosities and pore sizes
    Tony G van Tienen
    Orthopaedic Research Laboratory, Department of Orthopaedics, University Medical Center Nijmegen, The Netherlands
    Biomaterials 23:1731-8. 2002
    ..Ingrowth of fibrovascular tissue and thus healing capacity depended on porosity, pore sizes and compression modulus of the implant...
  24. ncbi The in-vitro bioactivity of mesoporous bioactive glasses
    Xiaoxia Yan
    Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai 200433, PR China
    Biomaterials 27:3396-403. 2006
    ..According to our results, MBGs calcined at 973K may possess the best in vitro bioactivity. The influences of the composition and calcination temperature upon bioactivity are explained in terms of the unique structures of MBGs...
  25. ncbi Porous poly(alpha-hydroxyacid)/Bioglass composite scaffolds for bone tissue engineering. I: Preparation and in vitro characterisation
    V Maquet
    Centre for Education and Research on Macromolecules, University of Liege, Belgium
    Biomaterials 25:4185-94. 2004
    ..Formation of hydroxyapatite on the surface of composites, as an indication of their bioactivity, was recorded by EDXA, X-ray diffractometry and confirmed by Raman spectroscopy...
  26. doi Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers
    Igor I Slowing
    Department of Chemistry and US Department of Energy Ames Laboratory, Iowa State University, Ames, Iowa 50011 3111, USA
    Adv Drug Deliv Rev 60:1278-88. 2008
    ..We envision that these MSN-based systems have a great potential for a variety of drug delivery applications, such as the site-specific delivery and intracellular controlled release of drugs, genes, and other therapeutic agents...
  27. doi Spherical mesoporous silica nanoparticles for loading and release of the poorly water-soluble drug telmisartan
    Yanzhuo Zhang
    Department of Pharmaceutics, Shenyang Pharmaceutical University P O Box 32, 103 Wenhua Road, Shenhe District, Shenyang, Liaoning Province 110016, PR China
    J Control Release 145:257-63. 2010
    ..We believe that the present study will help in the design of oral drug delivery systems for the dissolution enhancement and/or sustained release of poorly water-soluble drugs...
  28. ncbi Fast setting calcium phosphate-chitosan scaffold: mechanical properties and biocompatibility
    Hockin H K Xu
    Paffenbarger Research Center, American Dental Association Foundation, USA
    Biomaterials 26:1337-48. 2005
    ..The highly porous scaffold may facilitate bone ingrowth and implant fixation in vivo. In addition, the two to three times increase in strength may help extend the use of CPC to larger repairs in moderately stress-bearing locations...
  29. doi Cellular Ti-6Al-4V structures with interconnected macro porosity for bone implants fabricated by selective electron beam melting
    Peter Heinl
    University of Erlangen Nuremberg, Department of Materials Science Institute of Science and Technology of Metals, Martensstrasse 5, 91058 Erlangen, Germany
    Acta Biomater 4:1536-44. 2008
    ..microCT) analysis demonstrated the capability to fabricate three-dimensional structures with an interconnected porosity and pore sizes suitable for tissue ingrowth and vascularization...
  30. pmc Biosensing using porous silicon double-layer interferometers: reflective interferometric Fourier transform spectroscopy
    Claudia Pacholski
    Department of Chemistry and Biochemistry, The University of California, San Diego, 9500 Gillman Drive, La Jolla, California 92093 0358, USA
    J Am Chem Soc 127:11636-45. 2005
    ..Detection can be accomplished either by computing the weighted difference in the frequencies of two peaks or by computing the ratio of the intensities of two peaks in the FFT spectrum...
  31. doi Impacts of mesoporous silica nanoparticle size, pore ordering, and pore integrity on hemolytic activity
    Yu Shen Lin
    Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, Minnesota 55455, USA
    J Am Chem Soc 132:4834-42. 2010
    ....
  32. pmc In vivo biodistribution and pharmacokinetics of silica nanoparticles as a function of geometry, porosity and surface characteristics
    Tian Yu
    Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT 84112, USA
    J Control Release 163:46-54. 2012
    ..In all, surface characteristics and porosity played important roles in influencing SiO(2) biodistribution and pharmacokinetics...
  33. ncbi Influence of the porosity of starch-based fiber mesh scaffolds on the proliferation and osteogenic differentiation of bone marrow stromal cells cultured in a flow perfusion bioreactor
    Manuela E Gomes
    3Bs Research Group, Biomaterials, Biodegradables and Biomimetics, University of Minho, Campus de Gualtar, Braga, Portugal
    Tissue Eng 12:801-9. 2006
    This study investigates the influence of the porosity of fiber mesh scaffolds obtained from a blend of starch and poly(epsilon-caprolactone) on the proliferation and osteogenic differentiation of marrow stromal cells cultured under static ..
  34. doi Mesoporous silicon particles as a multistage delivery system for imaging and therapeutic applications
    Ennio Tasciotti
    Nat Nanotechnol 3:151-7. 2008
    ..The use of this system is envisioned to open new avenues for avoiding biological barriers and delivering more than one therapeutic agent to the target at a time, in a time-controlled fashion...
  35. pmc In vitro release and in vitro-in vivo correlation for silybin meglumine incorporated into hollow-type mesoporous silica nanoparticles
    Xia Cao
    Department of Pharmaceutics, School of Pharmacy, Center for Nano Drug Gene Delivery and Tissue Engineering, Jiangsu University, Zhenjiang, People s Republic of China
    Int J Nanomedicine 7:753-62. 2012
    ..The purpose of this study was to develop a sustained drug-release model for water-soluble drugs using silica nanoparticles...
  36. doi Endothelial cells guided by immobilized gradients of vascular endothelial growth factor on porous collagen scaffolds
    Devang Odedra
    Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada
    Acta Biomater 7:3027-35. 2011
    ..Thus we concluded that the VEGF-165 gradient promoted the migration, but not proliferation, of cells into the scaffold. These gradient scaffolds provide the foundation for future in vivo tissue engineering studies...
  37. pmc In vitro and in vivo evaluation of ordered mesoporous silica as a novel adsorbent in liquisolid formulation
    Bao Chen
    School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou, People s Republic of China
    Int J Nanomedicine 7:199-209. 2012
    ..With the aim of improving adsorption capacity and accordingly achieving high drug loading, ordered mesoporous silica with a high surface area and narrow pore size distribution was synthesized and used in a liquisolid formulation...
  38. doi Sulfonate-grafted porous polymer networks for preferential CO2 adsorption at low pressure
    Weigang Lu
    Department of Chemistry, Texas A and M University, College Station, Texas 77842, United States
    J Am Chem Soc 133:18126-9. 2011
    ..Since these PPNs also possess ultrahigh physicochemical stability, practical applications in postcombustion capture of CO(2) lie well within the realm of possibility...
  39. doi Small calibre polyhedral oligomeric silsesquioxane nanocomposite cardiovascular grafts: influence of porosity on the structure, haemocompatibility and mechanical properties
    Maqsood Ahmed
    Centre for Nanotechnology and Regenerative Medicine, University College London, London, UK
    Acta Biomater 7:3857-67. 2011
    ..An important feature in determining the success of a graft is the wall structure, which includes porosity, pore size and pore interconnectivity, as these play a crucial role in determining the long-term patency of a ..
  40. pmc Increased cortical porosity in type 2 diabetic postmenopausal women with fragility fractures
    Janina M Patsch
    Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA
    J Bone Miner Res 28:313-24. 2013
    ..HR-pQCT images volumetric bone mineral density and cortical and trabecular structure measures, including cortical porosity, were calculated. Bone strength was estimated using micro-finite element analysis (µFEA)...
  41. pmc The biocompatibility of mesoporous silicates
    Sarah P Hudson
    Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Biomaterials 29:4045-55. 2008
    ..Although local tissue reaction to mesoporous silicates was benign, they caused severe systemic toxicity. This toxicity might be mitigated by modification of the materials...
  42. pmc Nano-fibrous scaffold for controlled delivery of recombinant human PDGF-BB
    Guobao Wei
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109 2209, USA
    J Control Release 112:103-10. 2006
    ..The successful generation of 3-D nano-fibrous scaffold incorporating controlled-release factors indicates significant potential for more complex tissue regeneration...
  43. doi Effect of beta-tricalcium phosphate particles with varying porosity on osteogenesis after sinus floor augmentation in humans
    Christine Knabe
    Department of Experimental Dentistry, Campus Benjamin Franklin, Charite University Medical Center Berlin, Abmannshauser Strasse 4 6, D 14197 Berlin, Germany
    Biomaterials 29:2249-58. 2008
    ..study examines the effect of two beta-tricalcium phosphate (TCP) particulate bone grafting materials with varying porosity on bone formation and on osteogenic marker expression 6 months after sinus floor augmentation...
  44. doi Synthesis and characterization of pore size-tunable magnetic mesoporous silica nanoparticles
    Jixi Zhang
    Nano Biomedical Research Center, Med X Research Institute, Shanghai Jiao Tong University, Shanghai, China
    J Colloid Interface Sci 361:16-24. 2011
    ..44-1.54 cm(3)/g). We also demonstrate their high potential in conventional DNA loading. Maximum loading capacity of salmon sperm DNA (375 mg/g) was obtained by the use of the M-MSN sample with the largest pore size of 6.1 nm...
  45. pmc Chitosan composites for bone tissue engineering--an overview
    Jayachandran Venkatesan
    Department of Chemistry, Pukyong National University, Busan 608 737, Korea
    Mar Drugs 8:2252-66. 2010
    ..Herein, the preparation, mechanical properties, chemical interactions and in vitro activity of chitosan composites for bone tissue engineering will be discussed...
  46. pmc Age- and gender-related differences in the geometric properties and biomechanical significance of intracortical porosity in the distal radius and tibia
    Andrew J Burghardt
    Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, USA
    J Bone Miner Res 25:983-93. 2010
    ..The goal of this study was to characterize intracortical porosity in a cross-sectional patient cohort using novel quantitative computational methods applied to high-resolution ..
  47. doi Use of ordered mesoporous silica to enhance the oral bioavailability of ezetimibe in dogs
    Filip Kiekens
    Formac Pharmaceuticals, Leuven, Belgium
    J Pharm Sci 101:1136-44. 2012
    ..In vivo evaluation in dogs confirmed the improvement of ezetimibe absorption with the use of OMS as drug delivery technology...
  48. doi Synthesis of double mesoporous core-shell silica spheres with tunable core porosity and their drug release and cancer cell apoptosis properties
    Ahmed Mohamed El-Toni
    King Abdullah Institute for Nanotechnology, King Saud University, Riyadh 11451, Saudi Arabia
    J Colloid Interface Sci 378:83-92. 2012
    ..The spherical size and porosity of the silica cores of DMCSS together with shell thickness can be tuned by controlling Stöber parameters, ..
  49. doi The packaging of siRNA within the mesoporous structure of silica nanoparticles
    Xu Li
    Nano Biomedical Research Center, School of Biomedical Engineering and Med X Research Institute, Shanghai Jiao Tong University, Shanghai 200030, China
    Biomaterials 32:9546-56. 2011
    ..In summary, our siRNA packaging strategy extends the application potential of M-MSNs and the resulting siRNA delivery vehicles can be further tested for in vivo experiments...
  50. doi Development of porous chitosan-gelatin/hydroxyapatite composite scaffolds for hard tissue-engineering applications
    C Isikli
    Department of Biomedical Engineering, Middle East Technical University, Ankara, Turkey
    J Tissue Eng Regen Med 6:135-43. 2012
    ..It was shown that the scaffolds prepared from chitosan, gelatin and HA are appropriate cell carriers for bone tissue engineering, especially those with sHA incorporated...
  51. doi Drug delivery formulations of ordered and nonordered mesoporous silica: comparison of three drug loading methods
    Tarja Limnell
    Division of Pharmaceutical Technology, Faculty of Pharmacy, FIN 00014 University of Helsinki, Helsinki, Finland
    J Pharm Sci 100:3294-306. 2011
    ..The fast release was also maintained after tableting. Loading of IMC into the Syloid particles alone was sufficient to produce similar IMC release profiles, as in the case of MCM-41 with the excipients...
  52. doi In vivo biodistribution and urinary excretion of mesoporous silica nanoparticles: effects of particle size and PEGylation
    Qianjun He
    State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding Xi Road, Shanghai 200050, P R China
    Small 7:271-80. 2011
    ..Neither MSNs nor PEGylated MSNs cause tissue toxicity after 1 month in vivo...
  53. doi Porous metal-organic-framework nanoscale carriers as a potential platform for drug delivery and imaging
    Patricia Horcajada
    Institut Lavoisier CNRS 8180 Institut universitaire de France, Universite de Versailles, 78035 Versailles Cedex, France
    Nat Mater 9:172-8. 2010
    ..In addition to their high loadings, they also potentially associate therapeutics and diagnostics, thus opening the way for theranostics, or personalized patient treatments...
  54. doi Porous scaffolds of polycaprolactone reinforced with in situ generated hydroxyapatite for bone tissue engineering
    Paola Fabbri
    Department of Materials and Environmental Engineering, University of Modena and Reggio Emilia, Modena, Italy
    J Mater Sci Mater Med 21:343-51. 2010
    ..Highly interconnected porosity was achieved by means of the salt-leaching technique using a mixture of sodium chloride and sodium bicarbonate as ..
  55. doi Mechanical evaluation of porous titanium (Ti6Al4V) structures with electron beam melting (EBM)
    Jayanthi Parthasarathy
    School of Industrial Engineering, University of Oklahoma, Norman, OK 73019, USA
    J Mech Behav Biomed Mater 3:249-59. 2010
    ..the processing of titanium has led to a one step fabrication of porous custom titanium implants with controlled porosity to meet the requirements of the anatomy and functions at the region of implantation...
  56. ncbi Bone ingrowth in porous titanium implants produced by 3D fiber deposition
    Jia Ping Li
    Department of Tissue Regeneration, Institute for Biomedical Technology, University of Twente, The Netherlands
    Biomaterials 28:2810-20. 2007
    ..deposition is a technique that allows the development of metallic scaffolds with accurately controlled pore size, porosity and interconnecting pore size, which in turn permits a more precise investigation of the effect of structural ..
  57. ncbi Biodegradable polymeric microspheres with "open/closed" pores for sustained release of human growth hormone
    Hong Kee Kim
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, 305 701, Republic of Korea
    J Control Release 112:167-74. 2006
    ..The resultant pore-closed microspheres exhibited high protein loading amount as well as sustained rhGH release profiles. Also, the released rhGH exhibited structural integrity after the treatment...
  58. ncbi Effect of activated carbons modification on porosity, surface structure and phenol adsorption
    G G Stavropoulos
    Chemical Engineering Department, Aristotle University of Thessaloniki, TEI campus, P O Box 1520, 54006 Thessaloniki, Greece
    J Hazard Mater 151:414-21. 2008
    ..The beneficial role of nitrogen on phenol adsorption was attributed to adsorbate-adsorbent interactions...
  59. ncbi Sintering and robocasting of beta-tricalcium phosphate scaffolds for orthopaedic applications
    Pedro Miranda
    Materials Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Rd, Berkeley, CA 94720, USA
    Acta Biomater 2:457-66. 2006
    beta-Tricalcium phosphate (beta-TCP) scaffolds with designed, three-dimensional (3-D) geometry and mesoscale porosity have been fabricated by direct-write assembly (robocasting) techniques...
  60. ncbi Porous gelatin hydrogels: 1. Cryogenic formation and structure analysis
    Sandra Van Vlierberghe
    Polymer Chemistry and Biomaterials Research Group, Ghent University, Krijgslaan 281, Building S4 Bis, B 9000 Ghent, Belgium
    Biomacromolecules 8:331-7. 2007
    ..In both cases, the porosity and pore size decreased gradually through the scaffolds...
  61. pmc The differential regulation of cell motile activity through matrix stiffness and porosity in three dimensional collagen matrices
    Miguel Miron-Mendoza
    Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd Dallas, TX 75390 9039, USA
    Biomaterials 31:6425-35. 2010
    ..collagen translocation, cell spreading and cell migration in relationship to collagen matrix stiffness and porosity. Collagen matrices prepared with 1-4 mg/ml collagen exhibited matrix stiffness (storage modulus measured by ..
  62. ncbi Increased plasma fibrin gel porosity in patients with Type I diabetes during continuous subcutaneous insulin infusion
    G Jörneskog
    Departments of Endocrinology and Diabetology, Karolinska Hospital, Karolinska Institutet, Stockholm, Sweden
    J Thromb Haemost 1:1195-201. 2003
    ..Patients with Type 1 diabetes have a tighter plasma fibrin gel structure, to which impaired glycemic control might contribute. Improved glycemic control can be achieved with continuous subcutaneous insulin infusion (CSII)...
  63. ncbi A novel method for biomaterial scaffold internal architecture design to match bone elastic properties with desired porosity
    Cheng Yu Lin
    Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109, USA
    J Biomech 37:623-36. 2004
    ..for initial function and appropriate remodeling of regenerating tissue while concurrently providing sufficient porosity for cell migration and cell/gene delivery...
  64. doi Preparation of aligned porous gelatin scaffolds by unidirectional freeze-drying method
    X Wu
    School of Science, Tianjin University, Tianjin 300072, China
    Acta Biomater 6:1167-77. 2010
    ..Scaffolds with tunable pore size and high porosity up to 98% were obtained by adjusting the concentration of the gelatin solution and crosslinking agent during the ..
  65. doi The relationship of root porosity and radial oxygen loss on arsenic tolerance and uptake in rice grains and straw
    X Q Mei
    State Key Laboratory for Bio control, and School of Life Sciences, Sun Yat Sen Zhongshan University, 135 Xin Gang West Road, Guangzhou 510275, PR China
    Environ Pollut 157:2550-7. 2009
    The correlations among arsenic (As) accumulation in grains and straw, rates of radial oxygen loss (ROL), and porosity of roots using 25 rice cultivars were investigated based on two pot experiments: (1) soil with addition of 100mg As kg(-..
  66. doi Multiscale modeling of fluid transport in tumors
    S Jonathan Chapman
    Mathematical Institute, University of Oxford, 24 29 St Giles, Oxford OX1 3LB, UK
    Bull Math Biol 70:2334-57. 2008
    ..This model is then homogenized to give a continuum description in terms of the vascular density. The resulting equations comprise a double porous medium with coupled Darcy flow through the interstitium and vasculature...
  67. ncbi Diffusion in musculoskeletal tissue engineering scaffolds: design issues related to porosity, permeability, architecture, and nutrient mixing
    Tejas S Karande
    Center for Clinical Bioengineering, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Ann Biomed Eng 32:1728-43. 2004
    ..The importance of diffusion in scaffolds and how it is influenced by porosity, permeability, architecture, and nutrient mixing has been emphasized...
  68. ncbi The influence of surface porosity on gap-healing around intra-articular implants in the presence of migrating particles
    Ole Rahbek
    Orthopedic Research Laboratory, Aarhus University Hospital, Nørrebrogade 44, Building 1A, DK 8000 Aarhus C, Denmark
    Biomaterials 26:4728-36. 2005
    ..A sealing effect against the migration of PE particles was found for both Fi and Pl implants in exact fit...
  69. ncbi State of the art and future directions of scaffold-based bone engineering from a biomaterials perspective
    Dietmar Werner Hutmacher
    Division of Bioengineering, National University of Singapore, 7 Engineering Dr 1, Singapore 11757
    J Tissue Eng Regen Med 1:245-60. 2007
    ..Advantages and limitations of these materials are analysed along with various architectural parameters of scaffolds important for bone tissue engineering, e.g. porosity, pore size, interconnectivity and pore-wall microstructures.
  70. ncbi Preparation of porous scaffolds by using freeze-extraction and freeze-gelation methods
    Ming Hua Ho
    Department of Chemical Engineering, National Taiwan University, Taipei 106, Taiwan
    Biomaterials 25:129-38. 2004
    ..In addition to the presentation of the morphologies of the fabricated scaffolds, preliminary data of cell culture on them are as well included in the present work...
  71. doi Postmenopausal women with osteopenia have higher cortical porosity and thinner cortices at the distal radius and tibia than women with normal aBMD: an in vivo HR-pQCT study
    Kyle K Nishiyama
    Department of Mechanical and Manufacturing Engineering, University of Calgary, Calgary, Canada
    J Bone Miner Res 25:882-90. 2010
    Increases in cortical porosity (Ct.Po) and decreases in cortical thickness (Ct.Th) are associated with increased bone fragility...
  72. ncbi Protecting against water loss: analysis of the barrier properties of plant cuticles
    M Riederer
    Julius von Sachs Institut fur Biowissenschaften, Universitat Wurzburg, Julius von Sachs Platz 3, D 97082 Wurzburg, Germany
    J Exp Bot 52:2023-32. 2001
    ..Open questions concerning the mechanistic understanding of the plant cuticular transport barrier and the role the plant cuticle plays in ensuring the survival and reproductive success of an individual plant are indicated...
  73. doi Porous bioactive nanostructured scaffolds for bone regeneration: a sol-gel solution
    Oliver Mahony
    Imperial College London, Department of Materials, South Kensington Campus, London, SW7 2AZ, UK
    Nanomedicine (Lond) 3:233-45. 2008
    ..Composites provide a partial solution to this problem, although their bioactive and degradation properties are not ideal, therefore novel nanocomposites are needed. The route to these potentially ideal materials is described...
  74. pmc Strategies and applications for incorporating physical and chemical signal gradients in tissue engineering
    Milind Singh
    Department of Chemical and Petroleum Engineering, University of Kansas, Lawrence, Kansas 66045 7609, USA
    Tissue Eng Part B Rev 14:341-66. 2008
    ..In the future, in vivo applications will shed more light on the performance of gradient-based mechanical integrity and signal delivery strategies compared to traditional tissue engineering approaches...
  75. pmc Pore formation induced by an antimicrobial peptide: electrostatic effects
    Frantz Jean-François
    UMR 5248, Centre National de la Recherche Scientifique Université Bordeaux 1, European Institute of Chemistry and Biology, Pessac, France
    Biophys J 95:5748-56. 2008
    ..Based on the simulation of a mutated peptide and the effects of small external electric fields, we conclude that electrostatic forces play a crucial role in the process of pore formation...
  76. doi Determination of the decay rate constant for hepatocytes immobilized in alginate microcapsules
    Aldo Leal-Egana
    Department of Cell Technology and Applied Stem Cell Biology, Biotechnology and Biomedicine Centre BBZ, University of Leipzig, Leipzig, Germany
    J Microencapsul 27:86-93. 2010
    ..According to the author's knowledge, this is the first report of a systematic study and determination of the K(d) value for immobilized hepatocytes, incorporating a wide range of cell concentrations within the alginate matrix...
  77. doi Design of porous polymeric scaffolds by gas foaming of heterogeneous blends
    A Salerno
    Department of Materials and Production Engineering and Interdisciplinary Research Centre on Biomaterials CRIB, University of Naples Federico II, 80125 Naples, Italy
    J Mater Sci Mater Med 20:2043-51. 2009
    ..Along this line, this study aimed at the design of porous scaffolds with controlled porosity and pore size distribution from blends of poly(epsilon-caprolactone) (PCL) and thermoplastic gelatin (TG), a ..
  78. doi Porous bioactive scaffold of aliphatic polyurethane and hydroxyapatite for tissue regeneration
    Li Wang
    Research Center for Nano Biomaterials, Analytical and Testing Center, Sichuan University, Chengdu 610064, People s Republic of China
    Biomed Mater 4:025003. 2009
    ..The HA/PU composite scaffold with a high HA content of about 60 wt% has a porosity of more than 78% and a pore size from 100 microm to 800 microm...
  79. doi Modulating the porosity of cryogels by influencing the nonfrozen liquid phase through the addition of inert solutes
    Harald Kirsebom
    Department of Biotechnology, Lund University, P O Box 124, SE 22100, Lund, Sweden
    Langmuir 26:16129-33. 2010
    ..The possibility of changing the structure and properties of the gels by adding different solutes could open up new applications for these materials, for example, chromatography applications...
  80. doi Nanobioengineered electrospun composite nanofibers and osteoblasts for bone regeneration
    Jayarama Reddy Venugopal
    Nanoscience and Nanotechnology Initiative, Division of Bioengineering, National University of Singapore, Singapore
    Artif Organs 32:388-97. 2008
    ..These fiber diameters were around 411 +/- 158 to 856 +/- 157 nm, and the pore size and porosity around 5-35 microm and 76-93%, respectively...
  81. doi Development of 3-D poly(trimethylenecarbonate-co-epsilon-caprolactone)-block-poly(p-dioxanone) scaffold for bone regeneration with high porosity using a wet electrospinning method
    Teo Jeon Shin
    Department of Dental Anesthesiology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, 110 768, Republic of Korea
    Biotechnol Lett 32:877-82. 2010
    ..05). Taken together, newly developed 3-D poly(trimethylenecarbonate-co-epsilon-caprolactone)-block-poly(p-dioxanone) scaffold is a promising candidate for bone regeneration...
  82. pmc Increase in pore area, and not pore density, is the main determinant in the development of porosity in human cortical bone
    C David L Thomas
    School of Dental Science, University of Melbourne, Victoria 3010, Australia
    J Anat 209:219-30. 2006
    This study investigated the relative contributions of pore size and pore density (number of pores per mm2) to porosity in the midshaft of the human femur...
  83. pmc Mechanism and kinetics of pore formation in membranes by water-soluble amphipathic peptides
    Ming Tao Lee
    National Synchrotron Radiation Research Center, Hsinchu 30076, Taiwan
    Proc Natl Acad Sci U S A 105:5087-92. 2008
    ..The mechanism includes a negative feedback that makes peptide-induced pores stable with a well defined size, contrary to the suggestion that peptides disintegrate the membrane in a detergent-like manner...
  84. doi Impactability and time-dependent mechanical properties of porous titanium particles for application in impaction grafting
    L H B Walschot
    Department of Orthopaedics, Orthopaedic Research Laboratory, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Biomed Mater Res B Appl Biomater 95:131-40. 2010
    ..1-2.5 MPa)) were assessed by standardized impaction and a confined compression test. Loaded samples were used for particle release analysis...
  85. pmc Porosity of human mandibular condylar bone
    G A P Renders
    Department of Functional Anatomy, Academic Centre for Dentistry Amsterdam ACTA, Universiteit van Amsterdam and Vrije Universiteit, The Netherlands
    J Anat 210:239-48. 2007
    Quantification of porosity and degree of mineralization of bone facilitates a better understanding of the possible effects of adaptive bone remodelling and the possible consequences for its mechanical properties...
  86. doi The effect of mesoporous bioactive glass on the physiochemical, biological and drug-release properties of poly(DL-lactide-co-glycolide) films
    Chengtie Wu
    Biomaterials and Tissue Engineering Research Unit, School of AMME, The University of Sydney, Sydney 2006, Australia
    Biomaterials 30:2199-208. 2009
    ....
  87. ncbi Cortical bone in the human femoral neck: three-dimensional appearance and porosity using synchrotron radiation
    Valerie Bousson
    Laboratoire de Radiologie Expérimentale, Faculte de Medecine Lariboisiere Saint Louis, Paris, France
    J Bone Miner Res 19:794-801. 2004
    ..radiation allowed visualization of the 3D cortical bone microarchitecture and measurement of intracortical porosity of femoral neck cortical bone specimens from 19 female cadavers imaged at 10.13-microm resolution...
  88. ncbi Porosity and its effect on the digestibility of dilute sulfuric acid pretreated corn stover
    Claudia I Ishizawa
    Chemical and Biosciences Center and National Bioenergy Center, National Renewable Energy Laboratory, 1617 Cole Boulevard, Golden, CO 80401 3393, USA
    J Agric Food Chem 55:2575-81. 2007
    ..Prior work has shown a strong correlation between porosity, measured as the change in the volume of pores accessible to a cellulase-sized molecule, and the initial ..
  89. doi Composite fibrous biomaterials for tissue engineering obtained using a supercritical CO2 antisolvent process
    C A García-González
    Instituto de Ciencia de Materiales de Barcelona ICMAB CSIC, Campus de la UAB s n, Bellaterra E 08193, Spain
    Acta Biomater 5:1094-103. 2009
    ..After further post-processing in a three-dimensional network, these nanofibers can potentially be used as scaffolds for tissue engineering...
  90. doi Porous polymer/hydroxyapatite scaffolds: characterization and biocompatibility investigations
    Timothy Douglas
    Department of Oral and Maxillofacial Surgery, University of Kiel, Arnold Heller Strasse 16, 24105, Kiel, Germany
    J Mater Sci Mater Med 20:1909-15. 2009
    ..It was shown that PLGA-HAP composites support osteoblast growth and vitality, paving the way for applications as bone tissue engineering scaffolds...
  91. doi Specimen size and porosity can introduce error into microCT-based tissue mineral density measurements
    Roberto J Fajardo
    Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Bone 44:176-84. 2009
    ..Measurements of rho(m) of specimens of unequal size or quantities of bone mineral must be interpreted with caution unless appropriate steps are taken to minimize these potential artifacts...
  92. doi An alternative technique to shape scaffolds with hierarchical porosity at physiological temperature
    Juan Pena
    Departamento de Quimica Inorganica y Bioinorganica, Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain
    Acta Biomater 6:1288-96. 2010
    ..network of interconnected pores (300-900 microm); in addition, a random and not necessarily connected porosity is generated, yielding a hierarchical porous architecture from the macro to the molecular scale...
  93. pmc Three-dimensional porous biodegradable polymeric scaffolds fabricated with biodegradable hydrogel porogens
    Jinku Kim
    Tissue Engineering and Biomaterials Laboratory, Departments of Orthopedic Surgery and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Tissue Eng Part C Methods 15:583-94. 2009
    ..The pore size distribution, porosity, pore interconnectivity, and spatial pore heterogeneity of the 3D PCLF scaffolds were assessed using micro-..
  94. ncbi Optimising bioactive glass scaffolds for bone tissue engineering
    Julian R Jones
    Department of Materials, Imperial College London, South Kensington Campus, London SW7 2AZ, UK
    Biomaterials 27:964-73. 2006
    ..The scaffolds also have textural porosity in the mesopore range (10-20 nm). The scaffolds were sintered at 600, 700, 800 and 1000 degrees C...
  95. doi The effect of BMP-2 on micro- and macroscale osteointegration of biphasic calcium phosphate scaffolds with multiscale porosity
    Sheeny K Lan Levengood
    Department of Materials Science and Engineering, University of Illinois at Urbana Champaign, 1304 West Green Street, Urbana, IL 61801, USA
    Acta Biomater 6:3283-91. 2010
    ..The combined effect of BMP-2, a potent osteoinductive growth factor, and multiscale porosity has yet to be investigated...
  96. pmc In vitro evaluation of macroporous hydrogels to facilitate stem cell infiltration, growth, and mineralization
    Vandana Keskar
    Department of Biopharmaceutical Sciences, University of Illinois, Chicago, IL 60612 7231, USA
    Tissue Eng Part A 15:1695-707. 2009
    ....
  97. doi Tissue engineering for total meniscal substitution: animal study in sheep model
    Elizaveta Kon
    Laboratorio di Biomeccanica, Rizzoli Orthopedic Institute, Bologna, Italy
    Tissue Eng Part A 14:1067-80. 2008
    ..Two different surgical implantation techniques in a sheep model were evaluated...
  98. doi Kinetic pathway of antimicrobial peptide magainin 2-induced pore formation in lipid membranes
    Yukihiro Tamba
    Integrated Bioscience Section, Graduate School of Science and Technology, Shizuoka University, 836 Oya, Suruga ku, Shizuoka 422 8529, Japan
    J Phys Chem B 114:12018-26. 2010
    ..We estimated the radius of these pores, which increases with an increase in magainin 2 concentration. On the basis of these data, we propose a hypothesis on the mechanism of magainin 2-induced pore formation...
  99. doi New insights into the pore structure of poly(d,l-lactide-co-glycolide) microspheres
    Kerstin Vay
    Sandoz GmbH, Sandoz Development Center Austria, Biochemiestrasse 10, A 6250 Kundl, Austria
    Int J Pharm 402:20-6. 2010
    ..From the envelope and the skeletal volume of the microspheres the porosity was calculated...
  100. pmc Porous silicon in drug delivery devices and materials
    Emily J Anglin
    Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093 0358, USA
    Adv Drug Deliv Rev 60:1266-77. 2008
    ..This paper reviews the preparation, chemistry, and properties of electrochemically prepared porous Si or SiO2 hosts relevant to drug delivery applications...
  101. pmc A fibrinogen-based precision microporous scaffold for tissue engineering
    Michael P Linnes
    Department of Bioengineering, University of Washington, 1705 NE Pacific Street, W H Foege Building, Rm N330L, Box 355061, Seattle, WA 98195, USA
    Biomaterials 28:5298-306. 2007
    ..We present a method to create a microporous, nanofibriliar fibrin scaffold that has controllable pore size, porosity, and microstructure for applications in tissue engineering...

Research Grants79

  1. Osteoinductive Injectable Degradable Polymeric Scaffold
    Michael Yaszemski; Fiscal Year: 2007
    ..may self-crosslink in the absence of a crosslinking agent, (2) the use of degradable hydrogel microspheres as the porosity generating method would both improve the scaffold's injectability and eliminate the step of solid porogen ..
  2. Resorbable Calcium Phosphate Ceramics for Bone Graft.
    Susmita Bose; Fiscal Year: 2010
    ..25:1, 1.33:1 and 1.5:1 on in vitro and in vivo resorption. 3) To develop 3D interconnected tailored porosity CaP structures using rapid prototyping, with an average 300 microns pore size, and, 30 and 60 volume % porosity ..
  3. Dental Stem Cells and Tooth Tissue Engineering
    Pamela C Yelick; Fiscal Year: 2010
    ..Silk scaffold fabrication methods, porosity, degradation rates, and added growth factor peptides, will be systematically evaluated...
  4. IN SITU POLYMERIZABLE GELS FOR DENTAL TISSUE ENGINEERING
    Antonios Mikos; Fiscal Year: 2002
    ..will be tested using a three-dimensional cell/polymer model developed in our laboratory to determine the optimal porosity and pore size of hydrogel scaffolds for maximum bone formation in vitro...
  5. Engineering fibrin polymers for enhanced angiogenesis
    THOMAS HARRISON BARKER; Fiscal Year: 2010
    ..These poor behaviors are primarily attributed to the polymer's lack of integrin-specific ligands and proper porosity. A fibrin polymer is capable of engaging many integrins on mostly inflammatory cells;however the lack of ..
  6. Engineering fibrin polymers for enhanced angiogenesis
    THOMAS HARRISON BARKER; Fiscal Year: 2010
    ..These poor behaviors are primarily attributed to the polymer's lack of integrin-specific ligands and proper porosity. A fibrin polymer is capable of engaging many integrins on mostly inflammatory cells;however the lack of ..
  7. Delivery of LEDGF for retinal degenerative disorders
    Uday Kompella; Fiscal Year: 2007
    ..This study will utilize supercritical fluid technology for controlling particle porosity, LEDGF release, and residual solvent content in microparticles and immunochemical methods for assessing retinal ..
  8. Tissue Engineering by a Non-Biologic Skin Substitute
    WILLIAM SEARE; Fiscal Year: 2005
    ..It creates a unique, 3- dimensional, open-cell porosity most useful when made in silicone rubbers...
  9. Resorbable Calcium Phosphate Ceramics for Bone Graft.
    Susmita Bose; Fiscal Year: 2010
    ..25:1, 1.33:1 and 1.5:1 on in vitro and in vivo resorption. 3) To develop 3D interconnected tailored porosity CaP structures using rapid prototyping, with an average 300 microns pore size, and, 30 and 60 volume % porosity ..
  10. Measuring the Efficacy of Endovascular Treatment of AAA
    Peter Faries; Fiscal Year: 2007
    ..The impact of stent graft porosity on the transmission of pressure to the aneurysm will also be studied...
  11. Resorbable Calcium Phosphate Ceramics for Bone Graft.
    Susmita Bose; Fiscal Year: 2009
    ..25:1, 1.33:1 and 1.5:1 on in vitro and in vivo resorption. 3) To develop 3D interconnected tailored porosity CaP structures using rapid prototyping, with an average 300 microns pore size, and, 30 and 60 volume % porosity ..
  12. Evaluating Low Ignition Propensity Cigarette Legislation
    RICHARD O CONNOR; Fiscal Year: 2007
    ..will examine changes in cigarette design (blend, tobacco weight, circumference, ventilation, paper citrate, paper porosity, rod moisture) due to the LIP laws, and whether these changes significantly affect ignition propensity or thermal ..
  13. Relative Influence of Scaffold Design/Material Parameters On Bone Regeneration
    Scott Hollister; Fiscal Year: 2007
    ..Aim 1: Computationally design and fabricate scaffolds architectures from HA/TCP, PLLA, and PCL at a single porosity of 60% with maximal and sub-maximal permeability Specific Aim 2: Determine elastic modulus and ultimate strength ..
  14. Relative Influence of Scaffold Design/Material Parameters On Bone Regeneration
    Scott J Hollister; Fiscal Year: 2010
    ..Aim 1: Computationally design and fabricate scaffolds architectures from HA/TCP, PLLA, and PCL at a single porosity of 60% with maximal and sub-maximal permeability Specific Aim 2: Determine elastic modulus and ultimate strength ..
  15. Structural and Dynamical Response of Escherichia coli to Osmotic Stress
    James C Weisshaar; Fiscal Year: 2010
    ..distribution of many globular proteins depends on the detailed structure of the nucleoid, especially on its porosity to proteins of different size and charge...
  16. Development of new elastic titanium immediate load implants
    Rong Wang; Fiscal Year: 2007
    ..Phase I has two Specific Aims: 1) identify a novel approach to create porosity and high Ti-content at the surface, and 2) demonstrate desirable surface morphology and biocompatibility for ..
  17. Pro-angiogenic Collagen Implants
    Joseph Backer; Fiscal Year: 2004
    ..implants, such as Apligraft TM (Organogenesis), do not hold protein therapeutics because of the required porosity of these materials...
  18. Bone Water and Mineralization Measured by Nuclear Magnetic Resonance
    Felix W Wehrli; Fiscal Year: 2010
    ..thinning of the cortex is partially offset by periosteal expansion, this process is accompanied by increased porosity. It is well known that increased porosity, a hallmark of enhanced bone turnover, significantly contributes to the ..
  19. POLYMER PARTICLES AS SEPARATION MEDIA FOR CHROMATOGRAPHY
    JEAN FRECHET; Fiscal Year: 2005
    ..of shape templates will be prepared, which use will enable the preparation of uniform 3 mu m beads with high porosity, well-defined regular surfaces, and tunable chemistry...
  20. The Mechanical Basis of Primary Open Angle Glaucoma
    Mark Johnson; Fiscal Year: 2010
    ..will allow us to definitively determine whether increased stiffness of SC cells leads to a decreased inner wall porosity and consequently the increased outflow resistance characteristic of most cases of POAG...
  21. The Mechanical Basis of Primary Open Angle Glaucoma
    Mark Johnson; Fiscal Year: 2010
    ..will allow us to definitively determine whether increased stiffness of SC cells leads to a decreased inner wall porosity and consequently the increased outflow resistance characteristic of most cases of POAG...
  22. The Mechanical Basis of Primary Open Angle Glaucoma
    Mark Johnson; Fiscal Year: 2009
    ..will allow us to definitively determine whether increased stiffness of SC cells leads to a decreased inner wall porosity and consequently the increased outflow resistance characteristic of most cases of POAG...
  23. Foreign Body Response as a Performance Metric for Implanted Scaffolds
    David W Grainger; Fiscal Year: 2010
    ..other requisite aspects of device in vivo performance, including tissue specific properties: tensile strength, porosity and micro-architecture, and custom defect-specific device morphologies (macrostructure)...
  24. Evaluating Low Ignition Propensity Cigarette Legislation
    RICHARD O CONNOR; Fiscal Year: 2009
    ..will examine changes in cigarette design (blend, tobacco weight, circumference, ventilation, paper citrate, paper porosity, rod moisture) due to the LIP laws, and whether these changes significantly affect ignition propensity or thermal ..
  25. EPIDEMIOLOGY OF AGE RELATED BONE LOSS AND FRACTURES
    Sundeep Khosla; Fiscal Year: 2004
    ..volumetric bone mineral density (BMD), and assessment of bone microstructural characteristics, such as cortical porosity and trabecular connectivity ("noninvasive bone biopsy")...
  26. EPIDEMIOLOGY OF AGE RELATED BONE LOSS AND FRACTURES
    B Riggs; Fiscal Year: 2001
    ..volumetric bone mineral density (BMD), and assessment of bone microstructural characteristics, such as cortical porosity and trabecular connectivity ("noninvasive bone biopsy")...