porosity

Summary

Summary: Condition of having pores or open spaces. This often refers to bones, bone implants, or bone cements, but can refer to the porous state of any solid substance.

Top Publications

  1. ncbi Porosity of 3D biomaterial scaffolds and osteogenesis
    Vassilis Karageorgiou
    Department of Chemical and Biological Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, USA
    Biomaterials 26:5474-91. 2005
  2. ncbi Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering
    K Rezwan
    Department of Materials, Imperial College London, Prince Consort Road, London SW7 2BP, UK
    Biomaterials 27:3413-31. 2006
  3. ncbi Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers
    Igor I Slowing
    Department of Chemistry and US Department of Energy Ames Laboratory, Iowa State University, Ames, Iowa 50011 3111, USA
    Adv Drug Deliv Rev 60:1278-88. 2008
  4. ncbi Ultrahigh porosity in metal-organic frameworks
    Hiroyasu Furukawa
    Center for Reticular Chemistry at the California NanoSystems Institute, and Department of Chemistry and Biochemistry, University of California Los Angeles UCLA, 607 Charles E Young Drive East, Los Angeles, CA 90095, USA
    Science 329:424-8. 2010
  5. ncbi Mesoporous silica nanoparticles for intracellular delivery of membrane-impermeable proteins
    Igor I Slowing
    Department of Chemistry, U S DOE Ames Laboratory, Iowa State University, Ames, Iowa 50011 3111, USA
    J Am Chem Soc 129:8845-9. 2007
  6. ncbi Mesoporous silica nanoparticles: synthesis, biocompatibility and drug delivery
    Fangqiong Tang
    Laboratory of Controllable Preparation and Application of Nanomaterials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, China
    Adv Mater 24:1504-34. 2012
  7. ncbi Intracortical remodelling and porosity in the distal radius and post-mortem femurs of women: a cross-sectional study
    Roger M D Zebaze
    Department of Medicine, Austin Health, University of Melbourne, Melbourne, Vic, Australia
    Lancet 375:1729-36. 2010
  8. ncbi Porous metal-organic-framework nanoscale carriers as a potential platform for drug delivery and imaging
    Patricia Horcajada
    Institut Lavoisier CNRS 8180 Institut universitaire de France, Universite de Versailles, 78035 Versailles Cedex, France
    Nat Mater 9:172-8. 2010
  9. pmc Cell colonization in degradable 3D porous matrices
    Benjamin J Lawrence
    School of Chemical Engineering, Oklahoma State University, Stillwater, Oklahoma 74078, USA
    Cell Adh Migr 2:9-16. 2008
  10. ncbi Ordered porous materials for emerging applications
    Mark E Davis
    Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA
    Nature 417:813-21. 2002

Detail Information

Publications306 found, 100 shown here

  1. ncbi Porosity of 3D biomaterial scaffolds and osteogenesis
    Vassilis Karageorgiou
    Department of Chemical and Biological Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, USA
    Biomaterials 26:5474-91. 2005
    b>Porosity and pore size of biomaterial scaffolds play a critical role in bone formation in vitro and in vivo...
  2. ncbi Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering
    K Rezwan
    Department of Materials, Imperial College London, Prince Consort Road, London SW7 2BP, UK
    Biomaterials 27:3413-31. 2006
    ....
  3. ncbi Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers
    Igor I Slowing
    Department of Chemistry and US Department of Energy Ames Laboratory, Iowa State University, Ames, Iowa 50011 3111, USA
    Adv Drug Deliv Rev 60:1278-88. 2008
    ..We envision that these MSN-based systems have a great potential for a variety of drug delivery applications, such as the site-specific delivery and intracellular controlled release of drugs, genes, and other therapeutic agents...
  4. ncbi Ultrahigh porosity in metal-organic frameworks
    Hiroyasu Furukawa
    Center for Reticular Chemistry at the California NanoSystems Institute, and Department of Chemistry and Biochemistry, University of California Los Angeles UCLA, 607 Charles E Young Drive East, Los Angeles, CA 90095, USA
    Science 329:424-8. 2010
    ..The volume-specific internal surface area of MOF-210 (2060 square meters per cubic centimeter) is equivalent to the outer surface of nanoparticles (3-nanometer cubes) and near the ultimate adsorption limit for solid materials...
  5. ncbi Mesoporous silica nanoparticles for intracellular delivery of membrane-impermeable proteins
    Igor I Slowing
    Department of Chemistry, U S DOE Ames Laboratory, Iowa State University, Ames, Iowa 50011 3111, USA
    J Am Chem Soc 129:8845-9. 2007
    ....
  6. ncbi Mesoporous silica nanoparticles: synthesis, biocompatibility and drug delivery
    Fangqiong Tang
    Laboratory of Controllable Preparation and Application of Nanomaterials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, China
    Adv Mater 24:1504-34. 2012
    ..We conclude with our personal perspectives on the directions in which future work in this field might be focused...
  7. ncbi Intracortical remodelling and porosity in the distal radius and post-mortem femurs of women: a cross-sectional study
    Roger M D Zebaze
    Department of Medicine, Austin Health, University of Melbourne, Melbourne, Vic, Australia
    Lancet 375:1729-36. 2010
    ..We aimed to re-examine cortical bone as a source of bone loss in the appendicular skeleton...
  8. ncbi Porous metal-organic-framework nanoscale carriers as a potential platform for drug delivery and imaging
    Patricia Horcajada
    Institut Lavoisier CNRS 8180 Institut universitaire de France, Universite de Versailles, 78035 Versailles Cedex, France
    Nat Mater 9:172-8. 2010
    ..In addition to their high loadings, they also potentially associate therapeutics and diagnostics, thus opening the way for theranostics, or personalized patient treatments...
  9. pmc Cell colonization in degradable 3D porous matrices
    Benjamin J Lawrence
    School of Chemical Engineering, Oklahoma State University, Stillwater, Oklahoma 74078, USA
    Cell Adh Migr 2:9-16. 2008
    ..Further, specific scaffold properties such as porosity, pore size, fiber thickness, topography and scaffold stiffness as well as important cell material interactions ..
  10. ncbi Ordered porous materials for emerging applications
    Mark E Davis
    Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA
    Nature 417:813-21. 2002
    ..In fact, porous materials now seem set to contribute to developments in areas ranging from microelectronics to medical diagnosis...
  11. ncbi The effect of pore size on cell adhesion in collagen-GAG scaffolds
    F J O'Brien
    Department of Mechanical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Rm 8 135, Cambridge, MA 02139, USA
    Biomaterials 26:433-41. 2005
    ..9-150.5 microm) of pore sizes for MC3T3 cells...
  12. ncbi Porous scaffold design for tissue engineering
    Scott J Hollister
    Scaffold Tissue Engineering Group, Department of Biomedical Engineering, The University of Michigan, Ann Arbor, Michigan 41809, USA
    Nat Mater 4:518-24. 2005
    ....
  13. ncbi Interaction of mesoporous silica nanoparticles with human red blood cell membranes: size and surface effects
    Yannan Zhao
    Department of Chemistry, U S Department of Energy Ames Laboratory, Iowa State University, Ames, Iowa 50011 3111, USA
    ACS Nano 5:1366-75. 2011
    ....
  14. ncbi Fabrication methods of porous metals for use in orthopaedic applications
    Garrett Ryan
    National University of Ireland, Department of Mechanical and Biomedical Engineering, Nun s Island, Galway, Ireland
    Biomaterials 27:2651-70. 2006
    ..Another potentially valuable property of porous materials is their low elastic modulus. Depending on the porosity, moduli can even be tailored to match the modulus of bone closer than solid metals can, thus reducing the ..
  15. pmc Age- and gender-related differences in the geometric properties and biomechanical significance of intracortical porosity in the distal radius and tibia
    Andrew J Burghardt
    Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, USA
    J Bone Miner Res 25:983-93. 2010
    ..The goal of this study was to characterize intracortical porosity in a cross-sectional patient cohort using novel quantitative computational methods applied to high-resolution ..
  16. ncbi Fabrication of solid-state nanopores with single-nanometre precision
    A J Storm
    Department of Nanoscience, Delft University of Technology, 2628 CJ Delft, The Netherlands
    Nat Mater 2:537-40. 2003
    ..When the electron beam is switched off, the material quenches and retains its shape. This technique dramatically increases the level of control in the fabrication of a wide range of nanodevices...
  17. ncbi Mesoporous silica nanoparticles as a delivery system for hydrophobic anticancer drugs
    Jie Lu
    Department of Microbiology, Immunology, and Molecular Genetics, California NanoSystems Institute, JCCC, University of California, Los Angeles, 609 Charles E Young Drive East, Los Angeles, CA 90095, USA
    Small 3:1341-6. 2007
  18. ncbi Wall architecture with high porosity is established at the tip and maintained in growing pollen tubes of Nicotiana tabacum
    Jan Derksen
    Department of Plant Cell Research, Institute for Wetland and Water Research IWWR, Radboud University Nijmegen, Heyendaalseweg 135, NL 6525 AJ Nijmegen, The Netherlands
    Plant J 68:495-506. 2011
    ..a barrier to interaction with the environment? Using cryo-FESEM, we directly assessed the 3D construction and porosity of tobacco pollen tube walls...
  19. ncbi Influence of PEG in PEG-PLGA microspheres on particle properties and protein release
    J Buske
    Laboratory of Pharmaceutical Engineering, Institute of Pharmacy, University of Bonn, Germany
    Eur J Pharm Biopharm 81:57-63. 2012
    ..Although the triblock copolymer consists of 10% PEG, the specific surface area was the lowest of all formulations. The rapid hydration due to PEG leads to a swollen matrix, which released the protein in a slow and continuous way...
  20. pmc Increased cortical porosity in type 2 diabetic postmenopausal women with fragility fractures
    Janina M Patsch
    Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA
    J Bone Miner Res 28:313-24. 2013
    ..HR-pQCT images volumetric bone mineral density and cortical and trabecular structure measures, including cortical porosity, were calculated. Bone strength was estimated using micro-finite element analysis (µFEA)...
  21. pmc In vivo biodistribution and pharmacokinetics of silica nanoparticles as a function of geometry, porosity and surface characteristics
    Tian Yu
    Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT 84112, USA
    J Control Release 163:46-54. 2012
    ..In all, surface characteristics and porosity played important roles in influencing SiO(2) biodistribution and pharmacokinetics...
  22. ncbi Control of porosity by using isoreticular zeolitic imidazolate frameworks (IRZIFs) as a template for porous carbon synthesis
    Pradip Pachfule
    Physical Materials Chemistry Division, CSIR National Chemical Laboratory, Dr Homi Bhabha Road, Pune 411008, India
    Chemistry 18:11399-408. 2012
    ..By using IRZIFs with variable porosity as templates, we could achieve control over the carbon porosity and H(2) and CO(2) uptake...
  23. ncbi Fabrication and cell affinity of biomimetic structured PLGA/articular cartilage ECM composite scaffold
    Xifu Zheng
    Department of Orthopedic Surgery, First Affiliated Hospital of Dalian Medical University, Dalian, 116011, China
    J Mater Sci Mater Med 22:693-704. 2011
    ..The composite scaffold has well oriented structure and more than 89% of porosity as well as about 107 μm of average pore diameter...
  24. ncbi Preparation of aligned porous gelatin scaffolds by unidirectional freeze-drying method
    X Wu
    School of Science, Tianjin University, Tianjin 300072, China
    Acta Biomater 6:1167-77. 2010
    ..Scaffolds with tunable pore size and high porosity up to 98% were obtained by adjusting the concentration of the gelatin solution and crosslinking agent during the ..
  25. ncbi Chiral nanoporous metal-organic frameworks with high porosity as materials for drug delivery
    Chun yi Sun
    Institute of Functional Materials Chemistry, Key Laboratory of Polyoxometalate Science of Ministry of Education, Department of Chemistry, Northeast Normal University Changchun, Jilin, 130024, China
    Adv Mater 23:5629-32. 2011
    A chiral nanoporous metal-organic framework (MOF) with high porosity is obtained based on nontoxic zinc and achiral hexadentate ligand...
  26. ncbi The packaging of siRNA within the mesoporous structure of silica nanoparticles
    Xu Li
    Nano Biomedical Research Center, School of Biomedical Engineering and Med X Research Institute, Shanghai Jiao Tong University, Shanghai 200030, China
    Biomaterials 32:9546-56. 2011
    ..In summary, our siRNA packaging strategy extends the application potential of M-MSNs and the resulting siRNA delivery vehicles can be further tested for in vivo experiments...
  27. ncbi 3D fiber-deposited scaffolds for tissue engineering: influence of pores geometry and architecture on dynamic mechanical properties
    L Moroni
    Institute for Biomedical Technology, University of Twente, P O Box 217, 7500 AE Enschede, The Netherlands
    Biomaterials 27:974-85. 2006
    ..With increasing porosity, dynamic mechanical analysis (DMA) revealed a decrease in elastic properties such as dynamic stiffness and ..
  28. ncbi Porosity of the wall of a Neurolac nerve conduit hampers nerve regeneration
    Marcel F Meek
    Department of Plastic and Hand Surgery, Scheper Hospital, Boermarkeweg 60, Emmen, The Netherlands com
    Microsurgery 29:473-8. 2009
    ..With porosity less biomaterial is used for the nerve conduit...
  29. ncbi Fabrication and characterization of porous poly(L-lactide) scaffolds using solid-liquid phase separation
    Yan Qi Goh
    Division of Bioengineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, Nanyang Avenue, Singapore, 639798, Singapore
    J Mater Sci Mater Med 19:2445-52. 2008
    ..The size of the longitudinal pores was in the range of 20-40 microm and the scaffolds had high porosity values ranging from 90% to 98%...
  30. ncbi An adaptable peptide-based porous material
    J Rabone
    Department of Chemistry, University of Liverpool, Liverpool, L69 7ZD, UK
    Science 329:1053-7. 2010
    ..We report a crystalline porous solid with adaptable porosity, in which a simple dipeptide linker is arranged in a regular array by coordination to metal centers...
  31. ncbi Design of porous scaffolds for cartilage tissue engineering using a three-dimensional fiber-deposition technique
    T B F Woodfield
    Institute for Biomedical Technology, University of Twente, Enschede, The Netherlands
    Biomaterials 25:4149-61. 2004
    ..By varying PEGT/PBT composition, porosity and pore geometry, 3D-deposited scaffolds were produced with a range of mechanical properties...
  32. ncbi Aerographite: ultra lightweight, flexible nanowall, carbon microtube material with outstanding mechanical performance
    Matthias Mecklenburg
    Istitute of Polymers and Composites, Hamburg University of Technology, Denickestr 15, D 21073 Hamburg, Germany
    Adv Mater 24:3486-90. 2012
    ..Despite its low density, the hierarchical design leads to remarkable mechanical, electrical, and optical properties. The first experiments with Aerographite electrodes confirm its applicability...
  33. pmc Mesoporous silica nanoparticles as drug delivery systems for targeted inhibition of Notch signaling in cancer
    Veronika Mamaeva
    Turku Centre for Biotechnology, University of Turku and Abo Akademi University, Turku, Finland
    Mol Ther 19:1538-46. 2011
    ..The data highlights MSNPs as an attractive platform for targeted drug delivery of anticancer drugs with otherwise restricted clinical application, and as interesting constituents in the quest for more refined Notch therapies...
  34. ncbi Mesoporous silica nanoparticles for intracellular controlled drug delivery
    Juan L Vivero-Escoto
    Department of Chemistry and U S Department of Energy, Ames Laboratory, Iowa State University, Ames, IA 50011 3111, USA
    Small 6:1952-67. 2010
    ..Finally, the latest breakthroughs for intracellular controlled drug release using stimuli-responsive mesoporous-silica-based systems are described...
  35. ncbi Highly porous large poly(lactic-co-glycolic acid) microspheres adsorbed with palmityl-acylated exendin-4 as a long-acting inhalation system for treating diabetes
    Hyunuk Kim
    College of Pharmacy, Pusan National University, Jangjun dong, Geumjeong Gu, Busan 609 735, Republic of Korea
    Biomaterials 32:1685-93. 2011
    ..We consider that this new prototype of porous PLGA MS has considerable pharmaceutical potential as a type 2 anti-diabetic inhalation treatment...
  36. ncbi Mesoporous silica as a membrane for ultra-thin implantable direct glucose fuel cells
    Tushar Sharma
    Department of Biomedical Engineering, University of Texas at Austin, Austin, TX 78712, USA
    Lab Chip 11:2460-5. 2011
    ..We demonstrate that a mesoporous silica thin film (270 nm) is capable of replacing the conventional polymer based membranes with an improvement in the power generated over conventional direct glucose fuel cells...
  37. ncbi Novel silk sericin/gelatin 3-D scaffolds and 2-D films: fabrication and characterization for potential tissue engineering applications
    Biman B Mandal
    Department of Biotechnology, Indian Institute of Technology, Kharagpur 721302, India
    Acta Biomater 5:3007-20. 2009
    ..The results of this novel study lay the foundation for the use of the silk cocoon protein sericin as a biocompatible biopolymer for tissue engineering applications...
  38. ncbi The shape effect of mesoporous silica nanoparticles on biodistribution, clearance, and biocompatibility in vivo
    Xinglu Huang
    Laboratory of Controllable Preparation and Application of Nanomaterials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences CAS, Beijing 100190, China
    ACS Nano 5:5390-9. 2011
    ..These findings may provide useful information for the design of nanoscale delivery systems and the environmental fate of nanoparticles...
  39. ncbi Exceptional behavior over the whole adsorption-storage-delivery cycle for NO in porous metal organic frameworks
    Alistair C McKinlay
    EaStCHEM School of Chemistry, University of St Andrews, Purdie Building, St Andrews KY16 9ST, UK
    J Am Chem Soc 130:10440-4. 2008
    ..The activity of the NO storage materials is proved in myography experiments showing that the NO-releasing MOFs cause relaxation of porcine arterial tissue...
  40. ncbi Diffusion in musculoskeletal tissue engineering scaffolds: design issues related to porosity, permeability, architecture, and nutrient mixing
    Tejas S Karande
    Center for Clinical Bioengineering, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Ann Biomed Eng 32:1728-43. 2004
    ..The importance of diffusion in scaffolds and how it is influenced by porosity, permeability, architecture, and nutrient mixing has been emphasized...
  41. pmc DNA translocation governed by interactions with solid-state nanopores
    Meni Wanunu
    Department of Biomedical Engineering and Department of Physics, Boston University, Boston, Massachusetts, USA
    Biophys J 95:4716-25. 2008
    ..These findings shed light on the transport properties of DNA in small pores, relevant for future nanopore applications, such as DNA sequencing and genotyping...
  42. ncbi Nanoporous polymers for hydrogen storage
    Jonathan Germain
    University of California Berkeley, 94720 1460, USA
    Small 5:1098-111. 2009
    ..Strategies for controlling hydrogen storage capacity and adsorption enthalpy via manipulation of surface area, pore size, and pore volume are discussed in detail...
  43. ncbi Effect of Er:YAG laser and organic matrix on porosity changes in human enamel
    Deng Ying
    Department of Preventive Dentistry, Faculty of Dentistry, National University of Singapore, 5 Lower Kent Ridge Road, 119074 Singapore, Republic of Singapore
    J Dent 32:41-6. 2004
    ..The aim of the present study is to further investigate the role of organic matters in the laser-induced porosity changes.
  44. ncbi The effect of mean pore size on cell attachment, proliferation and migration in collagen-glycosaminoglycan scaffolds for bone tissue engineering
    Ciara M Murphy
    Department of Anatomy, Royal College of Surgeons in Ireland, Dublin, Ireland
    Biomaterials 31:461-6. 2010
    ..An added advantage of the larger pores is a reduction in cell aggregations that develop along the edges of the scaffolds. Ultimately scaffolds with a mean pore size of 325 microm were deemed optimal for bone tissue engineering...
  45. ncbi Effect of scaffold architecture and pore size on smooth muscle cell growth
    Min Lee
    Department of Bioengineering, University of California, Los Angeles, California 90095, USA
    J Biomed Mater Res A 87:1010-6. 2008
    ..Scaffold pore size did not significantly affect cell growth after 14 days of culture. Optimization in the architectural design of scaffolds provides an alternative method to improve diffusion limitation in the 3D constructs...
  46. ncbi A comparative study of mesoporous glass/silk and non-mesoporous glass/silk scaffolds: physiochemistry and in vivo osteogenesis
    Chengtie Wu
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia
    Acta Biomater 7:2229-36. 2011
    ....
  47. ncbi The use of bone-graft substitutes in large bone defects: any specific needs?
    G M Calori
    COR, Orthopaedic Institute, G Pini, University of Milan, Italy
    Injury 42:S56-63. 2011
    ..The purpose of this study was to evaluate the type of materials used and their efficacy for the treatment of large bone defects in traumatology and orthopaedic surgery...
  48. ncbi Tissue engineering of bone: search for a better scaffold
    M Mastrogiacomo
    Dipartimento di Oncologia, Biologia e Genetica, Istituto Nazionale per la Ricerca sul Cancro, dell Universita di Genova, Italy
    Orthod Craniofac Res 8:277-84. 2005
    ..Different sources of osteoprogenitor cells have been suggested, bone marrow stromal cells (BMSC) being in most cases the first choice...
  49. ncbi Relaxation processes in supercooled confined water and implications for protein dynamics
    Jan Swenson
    Department of Applied Physics, Chalmers University of Technology, SE 412 96 Goteborg, Sweden
    Phys Rev Lett 96:247802. 2006
    ..Furthermore, it implies that deeply supercooled water in biological systems, such as membranes and proteins, generally shows only a local beta relaxation, a finding of importance for low temperature properties of biological materials...
  50. ncbi Chemical reduction of three-dimensional silica micro-assemblies into microporous silicon replicas
    Zhihao Bao
    School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    Nature 446:172-5. 2007
    ....
  51. pmc The differential regulation of cell motile activity through matrix stiffness and porosity in three dimensional collagen matrices
    Miguel Miron-Mendoza
    Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd Dallas, TX 75390 9039, USA
    Biomaterials 31:6425-35. 2010
    ..collagen translocation, cell spreading and cell migration in relationship to collagen matrix stiffness and porosity. Collagen matrices prepared with 1-4 mg/ml collagen exhibited matrix stiffness (storage modulus measured by ..
  52. ncbi Tissue ingrowth and degradation of two biodegradable porous polymers with different porosities and pore sizes
    Tony G van Tienen
    Orthopaedic Research Laboratory, Department of Orthopaedics, University Medical Center Nijmegen, The Netherlands
    Biomaterials 23:1731-8. 2002
    ..Ingrowth of fibrovascular tissue and thus healing capacity depended on porosity, pore sizes and compression modulus of the implant...
  53. ncbi Improvement of porous beta-TCP scaffolds with rhBMP-2 chitosan carrier film for bone tissue application
    Ander Abarrategi
    Instituto de Estudios Biofuncionales, Universidad Complutense, Madrid, Spain
    Tissue Eng Part A 14:1305-19. 2008
    ..Initial beta-TCP disks with an average diameter of 5.78 mm, 2.9 mm thickness, and 53% porosity were coated with a chitosan film...
  54. ncbi Mesoporous materials for drug delivery
    María Vallet-Regí
    Departamento de Quimica Inorganica y Bioinorganica, Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain
    Angew Chem Int Ed Engl 46:7548-58. 2007
    ..This Minireview deals with the advances in this field by the control of the textural parameters, surface functionalization, and the synthesis of sophisticated stimuli-response systems...
  55. ncbi Low stiffness porous Ti structures for load-bearing implants
    B Vamsi Krishna
    W M Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164 2920, USA
    Acta Biomater 3:997-1006. 2007
    ..to reduce effective stiffness for load-bearing implants. Young's modulus and 0.2% proof strength of these porous Ti samples having 35-42vol.% porosity are found to be similar to those of human cortical bone.
  56. ncbi Preparation and characterization of bioactive mesoporous wollastonite - Polycaprolactone composite scaffold
    Jie Wei
    Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, PR China
    Biomaterials 30:1080-8. 2009
    ..Such improved properties of m-WPC should be helpful for developing new biomaterials and may have potential use in hard tissue repair...
  57. ncbi Strength, fracture toughness and microstructure of a selection of all-ceramic materials. Part II. Zirconia-based dental ceramics
    Massimiliano Guazzato
    Biomaterials Science Research Unit, Faculty of Dentistry, University of Sydney, United Dental Hospital, 2 Chalmers Street, Surry Hills, NSW, Australia 2010
    Dent Mater 20:449-56. 2004
    ..In the present study, DC Zirkon, an experimental yttria partially stabilized zirconia, In-Ceram Zirconia slip and In-Ceram Zirconia dry-pressed were compared...
  58. pmc Structure of transmembrane pore induced by Bax-derived peptide: evidence for lipidic pores
    Shuo Qian
    Department of Physics and Astronomy, Rice University, Houston, TX 77251, USA
    Proc Natl Acad Sci U S A 105:17379-83. 2008
    ..Evidence suggests that the formation of such lipidic pores is a major mechanism for alpha-pore-forming proteins, including apoptosis-regulator Bax...
  59. ncbi Structure and properties of bilayer chitosan-gelatin scaffolds
    Jin Shu Mao
    Research Institute of Polymeric Materials, Tianjin University, Tianjin 300072, China
    Biomaterials 24:1067-74. 2003
    ..These results suggested that the porosity and pore size of the scaffolds could be modulated with thermodynamic and kinetic parameters of ice formation...
  60. ncbi Porous poly(alpha-hydroxyacid)/Bioglass composite scaffolds for bone tissue engineering. I: Preparation and in vitro characterisation
    V Maquet
    Centre for Education and Research on Macromolecules, University of Liege, Belgium
    Biomaterials 25:4185-94. 2004
    ..Formation of hydroxyapatite on the surface of composites, as an indication of their bioactivity, was recorded by EDXA, X-ray diffractometry and confirmed by Raman spectroscopy...
  61. ncbi Postmenopausal women with osteopenia have higher cortical porosity and thinner cortices at the distal radius and tibia than women with normal aBMD: an in vivo HR-pQCT study
    Kyle K Nishiyama
    Department of Mechanical and Manufacturing Engineering, University of Calgary, Calgary, Canada
    J Bone Miner Res 25:882-90. 2010
    Increases in cortical porosity (Ct.Po) and decreases in cortical thickness (Ct.Th) are associated with increased bone fragility...
  62. ncbi Reconstruction of calvarial defect of rabbits using porous calcium silicate bioactive ceramics
    Songfeng Xu
    Institute of Orthopedic Surgery, Xijing Hospital, Fourth Military Medical University, Xi an 710032, PR China
    Biomaterials 29:2588-96. 2008
    ..The present studies showed that the porous beta-CS ceramics could stimulate bone regeneration and may be used as bioactive and biodegradable materials for hard tissue repair and tissue engineering applications...
  63. ncbi Mesoporous silicon microparticles for oral drug delivery: loading and release of five model drugs
    J Salonen
    Department of Physics, University of Turku, FI 20014 Turku, Finland
    J Control Release 108:362-74. 2005
    ..However, with poorly dissolving drugs, the loading into the mesoporous microparticles clearly improved dissolution. In addition, pH dependency of the dissolution was reduced when the drug substance was loaded into the microparticles...
  64. ncbi The in-vitro bioactivity of mesoporous bioactive glasses
    Xiaoxia Yan
    Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai 200433, PR China
    Biomaterials 27:3396-403. 2006
    ..According to our results, MBGs calcined at 973K may possess the best in vitro bioactivity. The influences of the composition and calcination temperature upon bioactivity are explained in terms of the unique structures of MBGs...
  65. ncbi Spherical mesoporous silica nanoparticles for loading and release of the poorly water-soluble drug telmisartan
    Yanzhuo Zhang
    Department of Pharmaceutics, Shenyang Pharmaceutical University P O Box 32, 103 Wenhua Road, Shenhe District, Shenyang, Liaoning Province 110016, PR China
    J Control Release 145:257-63. 2010
    ..We believe that the present study will help in the design of oral drug delivery systems for the dissolution enhancement and/or sustained release of poorly water-soluble drugs...
  66. ncbi Cellular Ti-6Al-4V structures with interconnected macro porosity for bone implants fabricated by selective electron beam melting
    Peter Heinl
    University of Erlangen Nuremberg, Department of Materials Science Institute of Science and Technology of Metals, Martensstrasse 5, 91058 Erlangen, Germany
    Acta Biomater 4:1536-44. 2008
    ..microCT) analysis demonstrated the capability to fabricate three-dimensional structures with an interconnected porosity and pore sizes suitable for tissue ingrowth and vascularization...
  67. ncbi Impacts of mesoporous silica nanoparticle size, pore ordering, and pore integrity on hemolytic activity
    Yu Shen Lin
    Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, Minnesota 55455, USA
    J Am Chem Soc 132:4834-42. 2010
    ....
  68. ncbi Fast setting calcium phosphate-chitosan scaffold: mechanical properties and biocompatibility
    Hockin H K Xu
    Paffenbarger Research Center, American Dental Association Foundation, USA
    Biomaterials 26:1337-48. 2005
    ..The highly porous scaffold may facilitate bone ingrowth and implant fixation in vivo. In addition, the two to three times increase in strength may help extend the use of CPC to larger repairs in moderately stress-bearing locations...
  69. pmc Biosensing using porous silicon double-layer interferometers: reflective interferometric Fourier transform spectroscopy
    Claudia Pacholski
    Department of Chemistry and Biochemistry, The University of California, San Diego, 9500 Gillman Drive, La Jolla, California 92093 0358, USA
    J Am Chem Soc 127:11636-45. 2005
    ..Detection can be accomplished either by computing the weighted difference in the frequencies of two peaks or by computing the ratio of the intensities of two peaks in the FFT spectrum...
  70. ncbi Porosity and pore size of beta-tricalcium phosphate scaffold can influence protein production and osteogenic differentiation of human mesenchymal stem cells: an in vitro and in vivo study
    Philip Kasten
    Orthopaedic University Hospital Heidelberg, Schlierbacher Landstr 200A, 69118 Heidelberg, Germany
    Acta Biomater 4:1904-15. 2008
    ..The aim of this study was to examine the influence of the porosity (25%, 65% and 75%) of beta-tricalcium phosphate (TCP) ceramics on osteogenic differentiation of mesenchymal stem ..
  71. ncbi Age-related changes in porosity and mineralization and in-service damage accumulation
    Timothy L Norman
    Department of Engineering and Computer Science, Cedarville University, 251 N Main Street, Cedarville, OH 45314, USA
    J Biomech 41:2868-73. 2008
    ..of bone turnover has also been proposed to increase bone microdamage through an increase in bone intracortical porosity and local stresses and strains. The goal of this paper was to investigate the above proposals, i.e...
  72. ncbi Effects of porosity and pore size on in vitro degradation of three-dimensional porous poly(D,L-lactide-co-glycolide) scaffolds for tissue engineering
    Linbo Wu
    Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200433, China
    J Biomed Mater Res A 75:767-77. 2005
    ..was performed in phosphate-buffered saline solution at 37 degrees C up to 26 weeks, and effects of porosity (80-95%) and pore size (50-450 mum) on the degradation of the scaffolds were investigated...
  73. ncbi Structure and properties of nano-hydroxyapatite/polymer composite scaffolds for bone tissue engineering
    Guobao Wei
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109 2009, USA
    Biomaterials 25:4749-57. 2004
    ..and the microstructure of natural bone, novel nano-hydroxyapatite (NHAP)/polymer composite scaffolds with high porosity and well-controlled pore architectures were prepared using thermally induced phase separation (TIPS) techniques...
  74. ncbi The absorption, distribution, excretion and toxicity of mesoporous silica nanoparticles in mice following different exposure routes
    Changhui Fu
    Laboratory of Controllable Preparation and Application of Nanomaterials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China
    Biomaterials 34:2565-75. 2013
    ..This study will be helpful for selecting the appropriate exposed routes for the development of nanomaterials-based drug delivery system for biomedical applications...
  75. pmc Stimulus-responsive controlled release system by covalent immobilization of an enzyme into mesoporous silica nanoparticles
    Jessica Méndez
    Department of Chemistry, University of Puerto Rico, Rio Piedras Campus, P O Box 23346, San Juan, PR 00931 3346, USA
    Bioconjug Chem 23:698-704. 2012
    ..In summary, we demonstrate the potential of MSN as drug delivery systems for proteins...
  76. pmc Pit membrane porosity and water stress-induced cavitation in four co-existing dry rainforest tree species
    Brendan Choat
    Department of Tropical Plant Science, James Cook University, Townsville, Queensland, Australia
    Plant Physiol 131:41-8. 2003
    ..56 MPa in A. excelsa and -5.12 MPa in A. bidwillii. To determine whether pit membrane porosity was responsible for greater vulnerability to embolism (air seeding hypothesis), pit membrane structure was ..
  77. ncbi Fast and precise method for HPLC-size exclusion chromatography with UV and TOC (NDIR) detection: importance of multiple detectors to evaluate the characteristics of dissolved organic matter
    Nobuyuki Kawasaki
    National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Water Res 45:6240-8. 2011
    ..The possible sources and reactivity of DOM in Lake Kasumigaura and its sediment pore water are also discussed...
  78. pmc Porous surface modified bioactive bone cement for enhanced bone bonding
    Qiang He
    Institute of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi, People s Republic of China
    PLoS ONE 7:e42525. 2012
    ..In this paper, we reported a porous surface modified bioactive bone cement with desired mechanical properties, which could allow for bone ingrowth...
  79. ncbi Effect of strontium-substituted nanohydroxyapatite coating of porous implant surfaces on implant osseointegration in a rabbit model
    Guo Li Yang
    Department of Implantology, Stomatology Hospital, Medical School, Zhejiang University, Hangzhou, China
    Int J Oral Maxillofac Implants 27:1332-9. 2012
    ..This study investigated the effects of a strontium-substituted nanohydroxyapatite (Sr-HA) coating, deposited onto porous implant surfaces using an electrochemical process, on implant osseointegration in a rabbit model...
  80. pmc Residues in the pore region of Drosophila transient receptor potential A1 dictate sensitivity to thermal stimuli
    Hong Wang
    Mouse Biology Unit, European Molecular Biology Laboratory EMBL, Via Ramarini 32, 00015 Monterotondo, Italy
    J Physiol 591:185-201. 2013
    ..Our results reveal specific molecular requirements for thermal activation of TRPA1 and provide mechanistic insight into this process...
  81. ncbi Properties and modification of porous 3-D collagen/hydroxyapatite composites
    A Sionkowska
    Faculty of Chemistry, N Copernicus University, Gagarin 7, 87 100 Torun, Poland
    Int J Biol Macromol 52:250-9. 2013
    ..Physical cross-linking was achieved by dehydrothermal treatment. Mechanical properties, morphology, dissolution, porosity, density, enzymatic degradation and swelling properties of materials have been studied after cross-linking...
  82. pmc In vitro and in vivo evaluation of ordered mesoporous silica as a novel adsorbent in liquisolid formulation
    Bao Chen
    School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou, People s Republic of China
    Int J Nanomedicine 7:199-209. 2012
    ..With the aim of improving adsorption capacity and accordingly achieving high drug loading, ordered mesoporous silica with a high surface area and narrow pore size distribution was synthesized and used in a liquisolid formulation...
  83. ncbi Sulfonate-grafted porous polymer networks for preferential CO2 adsorption at low pressure
    Weigang Lu
    Department of Chemistry, Texas A and M University, College Station, Texas 77842, United States
    J Am Chem Soc 133:18126-9. 2011
    ..Since these PPNs also possess ultrahigh physicochemical stability, practical applications in postcombustion capture of CO(2) lie well within the realm of possibility...
  84. ncbi Endothelial cells guided by immobilized gradients of vascular endothelial growth factor on porous collagen scaffolds
    Devang Odedra
    Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada
    Acta Biomater 7:3027-35. 2011
    ..Thus we concluded that the VEGF-165 gradient promoted the migration, but not proliferation, of cells into the scaffold. These gradient scaffolds provide the foundation for future in vivo tissue engineering studies...
  85. pmc In vitro release and in vitro-in vivo correlation for silybin meglumine incorporated into hollow-type mesoporous silica nanoparticles
    Xia Cao
    Department of Pharmaceutics, School of Pharmacy, Center for Nano Drug Gene Delivery and Tissue Engineering, Jiangsu University, Zhenjiang, People s Republic of China
    Int J Nanomedicine 7:753-62. 2012
    ..The purpose of this study was to develop a sustained drug-release model for water-soluble drugs using silica nanoparticles...
  86. ncbi Influence of the porosity of starch-based fiber mesh scaffolds on the proliferation and osteogenic differentiation of bone marrow stromal cells cultured in a flow perfusion bioreactor
    Manuela E Gomes
    3Bs Research Group, Biomaterials, Biodegradables and Biomimetics, University of Minho, Campus de Gualtar, Braga, Portugal
    Tissue Eng 12:801-9. 2006
    This study investigates the influence of the porosity of fiber mesh scaffolds obtained from a blend of starch and poly(epsilon-caprolactone) on the proliferation and osteogenic differentiation of marrow stromal cells cultured under static ..
  87. doi Mesoporous silicon particles as a multistage delivery system for imaging and therapeutic applications
    Ennio Tasciotti
    Nat Nanotechnol 3:151-7. 2008
    ..The use of this system is envisioned to open new avenues for avoiding biological barriers and delivering more than one therapeutic agent to the target at a time, in a time-controlled fashion...
  88. ncbi Small calibre polyhedral oligomeric silsesquioxane nanocomposite cardiovascular grafts: influence of porosity on the structure, haemocompatibility and mechanical properties
    Maqsood Ahmed
    Centre for Nanotechnology and Regenerative Medicine, University College London, London, UK
    Acta Biomater 7:3857-67. 2011
    ..An important feature in determining the success of a graft is the wall structure, which includes porosity, pore size and pore interconnectivity, as these play a crucial role in determining the long-term patency of a ..
  89. ncbi Effect of beta-tricalcium phosphate particles with varying porosity on osteogenesis after sinus floor augmentation in humans
    Christine Knabe
    Department of Experimental Dentistry, Campus Benjamin Franklin, Charite University Medical Center Berlin, Abmannshauser Strasse 4 6, D 14197 Berlin, Germany
    Biomaterials 29:2249-58. 2008
    ..study examines the effect of two beta-tricalcium phosphate (TCP) particulate bone grafting materials with varying porosity on bone formation and on osteogenic marker expression 6 months after sinus floor augmentation...
  90. ncbi Drug delivery formulations of ordered and nonordered mesoporous silica: comparison of three drug loading methods
    Tarja Limnell
    Division of Pharmaceutical Technology, Faculty of Pharmacy, FIN 00014 University of Helsinki, Helsinki, Finland
    J Pharm Sci 100:3294-306. 2011
    ..The fast release was also maintained after tableting. Loading of IMC into the Syloid particles alone was sufficient to produce similar IMC release profiles, as in the case of MCM-41 with the excipients...
  91. ncbi Use of ordered mesoporous silica to enhance the oral bioavailability of ezetimibe in dogs
    Filip Kiekens
    Formac Pharmaceuticals, Leuven, Belgium
    J Pharm Sci 101:1136-44. 2012
    ..In vivo evaluation in dogs confirmed the improvement of ezetimibe absorption with the use of OMS as drug delivery technology...
  92. pmc Chitosan composites for bone tissue engineering--an overview
    Jayachandran Venkatesan
    Department of Chemistry, Pukyong National University, Busan 608 737, Korea
    Mar Drugs 8:2252-66. 2010
    ..Herein, the preparation, mechanical properties, chemical interactions and in vitro activity of chitosan composites for bone tissue engineering will be discussed...
  93. ncbi Synthesis and characterization of pore size-tunable magnetic mesoporous silica nanoparticles
    Jixi Zhang
    Nano Biomedical Research Center, Med X Research Institute, Shanghai Jiao Tong University, Shanghai, China
    J Colloid Interface Sci 361:16-24. 2011
    ..44-1.54 cm(3)/g). We also demonstrate their high potential in conventional DNA loading. Maximum loading capacity of salmon sperm DNA (375 mg/g) was obtained by the use of the M-MSN sample with the largest pore size of 6.1 nm...
  94. ncbi In vivo biodistribution and urinary excretion of mesoporous silica nanoparticles: effects of particle size and PEGylation
    Qianjun He
    State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding Xi Road, Shanghai 200050, P R China
    Small 7:271-80. 2011
    ..Neither MSNs nor PEGylated MSNs cause tissue toxicity after 1 month in vivo...
  95. pmc Nano-fibrous scaffold for controlled delivery of recombinant human PDGF-BB
    Guobao Wei
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109 2209, USA
    J Control Release 112:103-10. 2006
    ..The successful generation of 3-D nano-fibrous scaffold incorporating controlled-release factors indicates significant potential for more complex tissue regeneration...
  96. ncbi Synthesis of double mesoporous core-shell silica spheres with tunable core porosity and their drug release and cancer cell apoptosis properties
    Ahmed Mohamed El-Toni
    King Abdullah Institute for Nanotechnology, King Saud University, Riyadh 11451, Saudi Arabia
    J Colloid Interface Sci 378:83-92. 2012
    ..The spherical size and porosity of the silica cores of DMCSS together with shell thickness can be tuned by controlling Stöber parameters, ..
  97. ncbi Development of porous chitosan-gelatin/hydroxyapatite composite scaffolds for hard tissue-engineering applications
    C Isikli
    Department of Biomedical Engineering, Middle East Technical University, Ankara, Turkey
    J Tissue Eng Regen Med 6:135-43. 2012
    ..It was shown that the scaffolds prepared from chitosan, gelatin and HA are appropriate cell carriers for bone tissue engineering, especially those with sHA incorporated...
  98. pmc The biocompatibility of mesoporous silicates
    Sarah P Hudson
    Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Biomaterials 29:4045-55. 2008
    ..Although local tissue reaction to mesoporous silicates was benign, they caused severe systemic toxicity. This toxicity might be mitigated by modification of the materials...
  99. ncbi Porous scaffolds of polycaprolactone reinforced with in situ generated hydroxyapatite for bone tissue engineering
    Paola Fabbri
    Department of Materials and Environmental Engineering, University of Modena and Reggio Emilia, Modena, Italy
    J Mater Sci Mater Med 21:343-51. 2010
    ..Highly interconnected porosity was achieved by means of the salt-leaching technique using a mixture of sodium chloride and sodium bicarbonate as ..
  100. ncbi Bone ingrowth in porous titanium implants produced by 3D fiber deposition
    Jia Ping Li
    Department of Tissue Regeneration, Institute for Biomedical Technology, University of Twente, The Netherlands
    Biomaterials 28:2810-20. 2007
    ..deposition is a technique that allows the development of metallic scaffolds with accurately controlled pore size, porosity and interconnecting pore size, which in turn permits a more precise investigation of the effect of structural ..
  101. ncbi Biodegradable polymeric microspheres with "open/closed" pores for sustained release of human growth hormone
    Hong Kee Kim
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, 305 701, Republic of Korea
    J Control Release 112:167-74. 2006
    ..The resultant pore-closed microspheres exhibited high protein loading amount as well as sustained rhGH release profiles. Also, the released rhGH exhibited structural integrity after the treatment...

Research Grants67

  1. Prevention of age-associated musculoskeletal loss by n-3 fatty acids
    Md Mizanur Rahman; Fiscal Year: 2013
    ..n-3 FA with/without mild CR on bone health during aging, I will perform DXA to determine bone mass;analyze bone porosity, pore size distribution and fractions of mobile and bound water by nuclear magnetic resonance (NMR) to determine ..
  2. Aligned Tendon or Ligament Derived Matrix Nanoscaffolds for Rotator Cuff Repair
    Dianne Little; Fiscal Year: 2013
    ..Electrospinning into an aqueous solution and collection of multiple layers of scaffold (hydrospinning) increases porosity and further enhances cell infiltration compared to more traditional nanoscaffolds deposited as a single layer ..
  3. New Personal Sampling Methods that Conform to an Aerosol Deposition Convention
    DARRAH KAYE SLEETH; Fiscal Year: 2013
    ..e., what size particles it will collect) can be modified by altering the porosity and thickness of the foam...
  4. High Resolution Peripheral Quantitative CT
    MARY BETH LEONARD; Fiscal Year: 2013
    ..resolution compared to pQCT, and provides detailed 3D measures of the microarchitecture of trabecular bone and porosity of cortical bone, as well as geometry and vBMD of cortical and trabecular bone...
  5. Structural and Dynamical Response of Escherichia coli to Osmotic Stress
    James C Weisshaar; Fiscal Year: 2010
    ..distribution of many globular proteins depends on the detailed structure of the nucleoid, especially on its porosity to proteins of different size and charge...
  6. The interaction of anabolic and antiresorptive agents in osteoporosis therapy
    Joy Tsai; Fiscal Year: 2013
    ..therapy versus each individual agent on cortical and trabecular volumetric bone density, cortical thickness and porosity, trabecular microarchitecture, and estimated bone strength (via micro finite element analysis)...
  7. Engineering fibrin polymers for enhanced angiogenesis
    THOMAS HARRISON BARKER; Fiscal Year: 2013
    ..These poor behaviors are primarily attributed to the polymer's lack of integrin-specific ligands and proper porosity. A fibrin polymer is capable of engaging many integrins on mostly inflammatory cells;however the lack of ..
  8. MicroXCT-200 High Resolution 3D X-ray Microscope
    MOHAMMED PERVEZ AKHTER; Fiscal Year: 2013
    ..It has been used for the past half decade for failure analysis in microchips and rock porosity analysis in core samples obtained during oil and gas exploration...
  9. Fabrication of Denture Frameworks Using Titanium Alloys
    Marie Koike; Fiscal Year: 2010
    ..X-ray radiography will be used to detect casting defects and porosity. The frameworks will also be checked for any dimensional changes during the casting process...
  10. Imaging for Y90 Microscphere SIRT Planning
    Anthony J McGoron; Fiscal Year: 2012
    ..in phosphate buffer and characterized with respect to shape, size, size distribution, surface roughness, and porosity using scanning electron microscope...
  11. Nanostructured Porous Silicon / Polymer Composites as Ophthalmic Implants
    Keryn Anne Williams; Fiscal Year: 2013
    ..Variation of the porosity of the porous silicon component will alter the rate of silicon degradatio and lifetime of the matrix...
  12. CHANGES IN SKELETAL MICROARCHITECTURE FOLLOWING RENAL TRANSPLANTATION
    MARY BETH LEONARD; Fiscal Year: 2011
    ..PTH) secretion and mineral metabolism result in trabecular sclerosis, cortical thinning, and increased cortical porosity. Fracture rates in dialysis patients are markedly increased, and increase further following renal transplantation...
  13. The Mechanical Basis of Primary Open Angle Glaucoma
    Mark Johnson; Fiscal Year: 2013
    ..will allow us to definitively determine whether increased stiffness of SC cells leads to a decreased inner wall porosity and consequently the increased outflow resistance characteristic of most cases of POAG...
  14. Novel Biometric Tissue Architecture as a Cell Delivery Vehicle for Cardiac Regene
    William S Turner; Fiscal Year: 2010
    ..2) To develop an optimal architectural design for the proposed 3-D patch which incorporates appropriate porosity for each gel working towards seeding at high cell densities and integration of layers of different materials...
  15. Protein-Releasing Microporous Scaffolds for Cell Replacement Therapy
    Lonnie D Shea; Fiscal Year: 2013
    ..i) 1) To investigate the hypothesis that the scaffold architecture, as defined by porosity, pore size, and stability, will influence islet engraftment and function...
  16. Magnetic Resonance Imaging of Bound and Free Water in Cortical Bone
    Jiang Du; Fiscal Year: 2013
    ..The free water content can potentially provide a surrogate measure of bone porosity. However, neither DEXA nor CT can detect either bound or free water in cortical bone...
  17. Tight Junction Barriers in the Gastrointestinal Tract
    James Melvin Anderson; Fiscal Year: 2010
    ..the pores and may confer different pore sizes and numbers;other adhesion proteins like occludin may control porosity. The role of these proteins in regulating permselectivity will be tested in overexpression, mutational and siRNA ..
  18. Injectable and Preformed Osteoinductive Biodegradable Composites
    Michael J Yaszemski; Fiscal Year: 2013
    ..This dual porosity generation will affect dual, sequential delivery of angiogenic and osteoinductive factors to provide an initial ..
  19. Cortical Bone Porosity Identifies Diabetes Subjects With Fragility Fractures
    Thomas M Link; Fiscal Year: 2010
    Cortical Bone Porosity Identifies Diabetes Subjects With Fragility Fractures Abstract The broad challenge area for this grant application is (03) Biomarker Discovery and Validation...
  20. Endplate permeability and spinal disc degeneration
    JEFFREY CHARLES LOTZ; Fiscal Year: 2010
    ..discs, measure their permeability, and relate this to specimen specific variables that include subchondral bone porosity and hyaline cartilage biochemistry and structure...
  21. Multifunctional bone putty for craniomaxillofacial bone repair
    AMBALANGODAGE CHAMPA JAYASURIYA; Fiscal Year: 2013
    ..to release C2+ and over time;immobility at the defect site;less mixing and working time at the operation room;porosity required for cell infiltration, bone formation-remodeling, and vascularization at the defect site...
  22. Porous Silicon Particles for Sustained Intravitreal Drug Delivery
    Lingyun Cheng; Fiscal Year: 2013
    ..We hypothesize that Psi particles are non-toxic and biodegradable after intravitreal injection, that their porosity can be used for hosting therapeutics, and that their optical property can be harnessed to report drug release ..
  23. The Roles of Collagen and Water in the Fracture Resistance of Bone
    JEFFRY STEPHEN NYMAN; Fiscal Year: 2013
    ..This will address the relevance of measuring matrix-bound water and porosity by NMR to improving bone health...
  24. Bone Fracture Risk Assessment Through Bound - and Pore - Water MRI
    Mark D Does; Fiscal Year: 2013
    ..method that does not incorporate the full contribution of macro-structure, micro-architecture, collagen, or porosity to fracture resistance...
  25. Bone Water and Mineralization Measured by Nuclear Magnetic Resonance
    Felix W Wehrli; Fiscal Year: 2011
    ..thinning of the cortex is partially offset by periosteal expansion, this process is accompanied by increased porosity. It is well known that increased porosity, a hallmark of enhanced bone turnover, significantly contributes to the ..
  26. Orthopedic Implants: Hypersonic Plasma Particle Deposition nano-porosity coatings
    Daniel A Fox; Fiscal Year: 2011
    ....
  27. Hybrid Organic-Inorganic Composite Materials for Bone Repairs
    ADEREMI R OKI; Fiscal Year: 2012
    ..relationship to provide guidance for predicting how fabrication variables, (ratio of organic : inorganic matrix, porosity, type of polymer and polymer to co-polymer ratio) affect bioactivity (bone bonding ability) when compared to bulk ..
  28. Hybrid Inorganic-Organic Hydrogel Scaffolds for Osteochondral Regeneration
    Mariah S Hahn; Fiscal Year: 2013
    ..Fabrication solvents of varying polarities will be used tailor PDMS distribution and porosity. Using existing gradient- making technologies, scaffolds will be prepared as gradients to permit rapid screening ..
  29. Dental Stem Cells and Tooth Tissue Engineering
    Pamela C Yelick; Fiscal Year: 2013
    ..Silk scaffold fabrication methods, porosity, degradation rates, and added growth factor peptides, will be systematically evaluated...
  30. In vivo imaging of cortical porosity in the peripheral skeleton
    Galateia J Kazakia; Fiscal Year: 2013
    ..to conduct a clinical investigation of the incidence, progression, and consequence of cortical marco-porosity in human subjects;4) to obtain training in clinical research, musculoskeletal diseases and statistical methods;..
  31. Development of an ex vivo derived laser drilled temporomandibular disc scaffold
    PETER STUART MCFETRIDGE; Fiscal Year: 2013
    ..Specific Aim 2: Design a high precision laser ablation paradigm that optimizes artificial porosity geometry for transport capability while minimizing mechanical degradation due to volume loss and microenvironment ..
  32. Novel ultrahigh resolution microCT imaging system
    Daniel S Perrien; Fiscal Year: 2010
    ..This system will open new avenues of research because it will resolve heretofore hidden features such as porosity in murine cortical bone, the spatial distribution of mineralization in trabeculae, the complete structure of ..
  33. Osteoporotic Fractures in Men (Mr. Os) Palo Alto
    Marcia L Stefanick; Fiscal Year: 2013
    ..skeletal fragility by using high resolution peripheral quantitative computed tomography to measure cortical porosity. We will relate trajectories of musculoskeletal health and activity to these measures of cortical bone and test ..
  34. Osteoporotic Fractures in Men (MrOS) - Administrative Center
    Eric S Orwoll; Fiscal Year: 2013
    ..skeletal fragility by using high resolution peripheral quantitative computed tomography to measure cortical porosity. We will relate trajectories of musculoskeletal health and activity to these measures of cortical bone and test ..
  35. OSTEOPOROTIC FRACTURES IN MEN (MR.OS)
    JANE ANN CAULEY; Fiscal Year: 2013
    ..skeletal fragility by using high resolution peripheral quantitative computed tomography to measure cortical porosity. We will relate trajectories of musculoskeletal health and activity to these measures of cortical bone and test ..
  36. DEVELOPMENT OF PICKERING EMULSIONS AS INJECTABLE BONE GRAFTS
    ELIZABETH MARIE COSGRIFF-HERNANDEZ; Fiscal Year: 2013
    ..is the translation of this technology to tissue engineering through the development of injectable, high porosity bone grafts...
  37. VAPOR GROWN CARBON FIBERS FOR BIOMEDICAL APPLICATIONS
    THOMAS APPLE; Fiscal Year: 1993
    ..We propose to coat fibers via plasma deposition with diamond to lower porosity and increase the physical strength of the fibers...
  38. In Vitro-In Vivo Correlation of Ocular Implants
    Uday B Kompella; Fiscal Year: 2013
    ..We hypothesize that key physicochemical properties such as implant surface area, porosity, tensile strength, and polymer degradation (due to polymer procurement from different sources) can differ for Q1/..
  39. Development of Tissue Scaffold of High Strength and Porosity
    JAMES JENQ LIU; Fiscal Year: 2011
    ..fiber we can engineer a synthetic biomaterial which has an optimized pore structure and high strength at high porosity. The osteoconductive and bioresorable nature of the bioactive glass fiber and our processing technique, would ..
  40. Modulating the BBB to Improve Drug Delivery to the Brain
    Teruna J Siahaan; Fiscal Year: 2013
    ..central hypothesis is that modulating the adherens junction of the BBB using E-cadherin peptides can enhance the porosity of the intercellular junctions and, thus, enhance the paracellular permeation of small and large anticancer drugs...
  41. Optimal Biodegradable Scaffolds and Progenitor Cells for Effective Bone Regenerat
    Ami R Amini; Fiscal Year: 2013
    ..First, we will design, fabricate and characterize (i.e., porosity, interconnectivity and mechanical strength) novel moderately-porous and mechanically strong PLGA microsphere ..
  42. Relative Influence of Scaffold Design/Material Parameters On Bone Regeneration
    Scott J Hollister; Fiscal Year: 2011
    ..Aim 1: Computationally design and fabricate scaffolds architectures from HA/TCP, PLLA, and PCL at a single porosity of 60% with maximal and sub-maximal permeability Specific Aim 2: Determine elastic modulus and ultimate strength ..
  43. Biomedical adhesives with precisely engineered surface topography and chemistry
    JEFFREY MICHAEL KARP; Fiscal Year: 2013
    ..polymers on the micro and nanoscale, and by systematically developing an understanding of how topography, porosity, and chemistry influence adhesion to biological tissues...
  44. IN SITU POLYMERIZABLE GELS FOR DENTAL TISSUE ENGINEERING
    Antonios Mikos; Fiscal Year: 2002
    ..will be tested using a three-dimensional cell/polymer model developed in our laboratory to determine the optimal porosity and pore size of hydrogel scaffolds for maximum bone formation in vitro...
  45. Biodegradable Self-Inductive Scaffold for Cranial Regeneration
    Esmaiel Jabbari; Fiscal Year: 2010
    ..In the first part of Aim 1, the effect of PLGF composition and scaffold porosity on degradation characteristics and mechanical strength will be determined. The outcome of Aim 1...
  46. Foreign Body Response as a Performance Metric for Implanted Scaffolds
    David W Grainger; Fiscal Year: 2013
    ..other requisite aspects of device in vivo performance, including tissue specific properties: tensile strength, porosity and micro-architecture, and custom defect-specific device morphologies (macrostructure)...
  47. Tissue Engineering by a Non-Biologic Skin Substitute
    WILLIAM SEARE; Fiscal Year: 2005
    ..It creates a unique, 3- dimensional, open-cell porosity most useful when made in silicone rubbers...
  48. Engineered Multi-Functional Nanofibrous Meniscus Implants
    John Esterhai; Fiscal Year: 2009
    ..First, a sacrificial element is engineered into the system to enhance porosity while maintaining fiber alignment critical to meniscus function...
  49. Measuring the Efficacy of Endovascular Treatment of AAA
    Peter Faries; Fiscal Year: 2007
    ..The impact of stent graft porosity on the transmission of pressure to the aneurysm will also be studied...
  50. FIBER OPTIC SENSORS BASED ON POLMER SWELLING
    RUDOLF SEITZ; Fiscal Year: 1999
    ..Develop procedures for simultaneously and independently controlling microsphere porosity and hydrophilicity using two-step seeded polymerization: The amount of porogenic solvent added in the second ..
  51. Visualizing Cortical Pore Space Constituents
    Galateia J Kazakia; Fiscal Year: 2013
    ..Cortical microstructure, in particular porosity, has a significant impact on mechanical properties of the cortex...
  52. SUBCELLULAR MECHANISMS OF PLATELET ACTIVATION
    Timothy J Stalker; Fiscal Year: 2013
    ..structure comprised of distinct regions that vary in the extent of platelet activation, packing density and porosity. A prominent feature is a core of fully-activated platelets overlaid with an unstable shell of less-activated ..
  53. Development of new elastic titanium immediate load implants
    Rong Wang; Fiscal Year: 2007
    ..Phase I has two Specific Aims: 1) identify a novel approach to create porosity and high Ti-content at the surface, and 2) demonstrate desirable surface morphology and biocompatibility for ..
  54. CHILDHOOD IMMUNIZATION FOR DENTAL CARIES
    DEBRA TRANTOLO; Fiscal Year: 2000
    ..of mutans streptococci by providing binding sites for cariogenic mutans streptococci as well as changing the porosity of dental plaque...
  55. Sorbents for Removal of Arsenic and Heavy Metals
    JOHN LOVELL; Fiscal Year: 2003
    ..arsenic with emerging technology from Texas A&M to bind the clay to sand or other materials that increase the porosity of the sorbent and allow its use in water treatment...
  56. Pro-angiogenic Collagen Implants
    Joseph Backer; Fiscal Year: 2004
    ..implants, such as Apligraft TM (Organogenesis), do not hold protein therapeutics because of the required porosity of these materials...
  57. POLYMER PARTICLES AS SEPARATION MEDIA FOR CHROMATOGRAPHY
    JEAN FRECHET; Fiscal Year: 2005
    ..of shape templates will be prepared, which use will enable the preparation of uniform 3 mu m beads with high porosity, well-defined regular surfaces, and tunable chemistry...
  58. Novel Freeze-Cast Bioactive Glass Scaffolds for Bone Repair
    MOHAMED RAHAMAN; Fiscal Year: 2009
    ..and solvent composition, scaffolds with a combination of high compressive strength, high strain to failure, high porosity, and large pore size for tissue ingrowth can be created by a unidirectional freeze casting process...
  59. MECHANISMS OF CORTICAL BONE FRAGILITY
    TIMOTHY NORMAN; Fiscal Year: 2000
    ..The important features were found to be those associated with bone remodeling: osteon morphology, porosity (density) and microdamage...
  60. BIOABSORABLE MEMBRANES FOR PREVENTION OF ADHESIONS
    Dufei Fang; Fiscal Year: 2002
    ..diameters of the fibers over a very broad size range from about 10 - 1000 nanometers, (ii) design textures and porosity of the nonwoven structures with controlled thickness of the membrane, and (iii) introduce medications, such as ..
  61. BIOCHEMICAL CHARACTERIZATION OF AMELOGENESIS IMPERFECTA
    John Wright; Fiscal Year: 1993
    ..volume giving accurate determinations of Ca and P while taking into account the tissue porosity. The use of microdissection and conservative histological preparation techniques allows all histological and ..
  62. Evaluating Low Ignition Propensity Cigarette Legislation
    RICHARD O CONNOR; Fiscal Year: 2009
    ..will examine changes in cigarette design (blend, tobacco weight, circumference, ventilation, paper citrate, paper porosity, rod moisture) due to the LIP laws, and whether these changes significantly affect ignition propensity or thermal ..