phase transition

Summary

Summary: A change of a substance from one form or state to another.

Top Publications

  1. ncbi Germline P granules are liquid droplets that localize by controlled dissolution/condensation
    Clifford P Brangwynne
    Max Planck Institute for Molecular Cell Biology and Genetics, 01307 Dresden, Germany
    Science 324:1729-32. 2009
  2. pmc Separation of liquid phases in giant vesicles of ternary mixtures of phospholipids and cholesterol
    Sarah L Veatch
    Departments of Chemistry and Physics, University of Washington, Seattle, Washington 98195 1700, USA
    Biophys J 85:3074-83. 2003
  3. pmc Myelin membrane assembly is driven by a phase transition of myelin basic proteins into a cohesive protein meshwork
    Shweta Aggarwal
    Max Planck Institute of Experimental Medicine, Gottingen, Germany
    PLoS Biol 11:e1001577. 2013
  4. ncbi Frequency tunable near-infrared metamaterials based on VO2 phase transition
    Matthew J Dicken
    California Institute of Technology, 1200 E California Boulevard, Pasadena, California, USA
    Opt Express 17:18330-9. 2009
  5. ncbi Phase transition in the collective migration of tissue cells: experiment and model
    B Szabo
    Department of Biological Physics, Eotvos University, Pázmány P stny 1A, H 1117 Budapest, Hungary
    Phys Rev E Stat Nonlin Soft Matter Phys 74:061908. 2006
  6. ncbi Relationships between equilibrium spreading pressure and phase equilibria of phospholipid bilayers and monolayers at the air-water interface
    Heidi M Mansour
    School of Pharmacy, University of Wisconsin Madison, 777 Highland Avenue, Madison, Wisconsin 53705 2222, USA
    Langmuir 23:3809-19. 2007
  7. ncbi Characterization of the in situ structural and interfacial properties of the cationic hydrophobic heteropolypeptide, KL4, in lung surfactant bilayer and monolayer models at the air-water interface: implications for pulmonary surfactant delivery
    Heidi M Mansour
    Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin Madison, Madison, Wisconsin 53705, USA
    Mol Pharm 5:681-95. 2008
  8. ncbi Synthesis and characterization of PEG-PCL-PEG thermosensitive hydrogel
    ChangYang Gong
    State Key Laboratory of Biotherapy, West China Hospital, and School of Life Sciences, Sichuan University, Chengdu 610041, China
    Int J Pharm 365:89-99. 2009
  9. ncbi The relationship between water vapor absorption and desorption by phospholipids and bilayer phase transitions
    Heidi M Mansour
    School of Pharmacy, University of Wisconsin Madison, 777 Highland Avenue, Madison, Wisconsin 53705 2222, USA
    J Pharm Sci 96:377-96. 2007
  10. ncbi Prediction of TiO2 nanoparticle phase and shape transitions controlled by surface chemistry
    A S Barnard
    Center for Nanoscale Materials, Materials Science Division, Argonne National Laboratory, 9700 South Cass Ave, Argonne, Illinois 60439, USA
    Nano Lett 5:1261-6. 2005

Detail Information

Publications331 found, 100 shown here

  1. ncbi Germline P granules are liquid droplets that localize by controlled dissolution/condensation
    Clifford P Brangwynne
    Max Planck Institute for Molecular Cell Biology and Genetics, 01307 Dresden, Germany
    Science 324:1729-32. 2009
    ..This process reflects a classic phase transition, in which polarity proteins vary the condensation point across the cell...
  2. pmc Separation of liquid phases in giant vesicles of ternary mixtures of phospholipids and cholesterol
    Sarah L Veatch
    Departments of Chemistry and Physics, University of Washington, Seattle, Washington 98195 1700, USA
    Biophys J 85:3074-83. 2003
    ..To date, we have not observed macroscopic separation of liquid phases in only binary lipid mixtures...
  3. pmc Myelin membrane assembly is driven by a phase transition of myelin basic proteins into a cohesive protein meshwork
    Shweta Aggarwal
    Max Planck Institute of Experimental Medicine, Gottingen, Germany
    PLoS Biol 11:e1001577. 2013
    ..The association of myelin basic protein molecules to the inner leaflet of the membrane bilayer induces a phase transition into a cohesive mesh-like protein network...
  4. ncbi Frequency tunable near-infrared metamaterials based on VO2 phase transition
    Matthew J Dicken
    California Institute of Technology, 1200 E California Boulevard, Pasadena, California, USA
    Opt Express 17:18330-9. 2009
    ..Utilizing the metal-insulator phase transition in vanadium oxide (VO(2)), we demonstrate frequency-tunable metamaterials in the near-IR range, from 1...
  5. ncbi Phase transition in the collective migration of tissue cells: experiment and model
    B Szabo
    Department of Biological Physics, Eotvos University, Pázmány P stny 1A, H 1117 Budapest, Hungary
    Phys Rev E Stat Nonlin Soft Matter Phys 74:061908. 2006
    ..the overall density of the migrating cells, we have been able to demonstrate experimentally a kinetic phase transition from a disordered into an ordered state...
  6. ncbi Relationships between equilibrium spreading pressure and phase equilibria of phospholipid bilayers and monolayers at the air-water interface
    Heidi M Mansour
    School of Pharmacy, University of Wisconsin Madison, 777 Highland Avenue, Madison, Wisconsin 53705 2222, USA
    Langmuir 23:3809-19. 2007
    ..2 mN/m forming equilibrated gaseous monolayers, whereas spread monolayers collapse at a value of pic remaining around 30 mN/m, indicative of metastable gel bilayer formation...
  7. ncbi Characterization of the in situ structural and interfacial properties of the cationic hydrophobic heteropolypeptide, KL4, in lung surfactant bilayer and monolayer models at the air-water interface: implications for pulmonary surfactant delivery
    Heidi M Mansour
    Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin Madison, Madison, Wisconsin 53705, USA
    Mol Pharm 5:681-95. 2008
    ..Equilibrium phase transition temperatures were measured using differential scanning calorimetry (DSC)...
  8. ncbi Synthesis and characterization of PEG-PCL-PEG thermosensitive hydrogel
    ChangYang Gong
    State Key Laboratory of Biotherapy, West China Hospital, and School of Life Sciences, Sichuan University, Chengdu 610041, China
    Int J Pharm 365:89-99. 2009
    ..Sol-gel-sol phase transition diagrams were recorded using test tube inverting method, which depended on hydrophilic/hydrophobic balance in ..
  9. ncbi The relationship between water vapor absorption and desorption by phospholipids and bilayer phase transitions
    Heidi M Mansour
    School of Pharmacy, University of Wisconsin Madison, 777 Highland Avenue, Madison, Wisconsin 53705 2222, USA
    J Pharm Sci 96:377-96. 2007
    Water vapor absorption and desorption at 25 degrees C and phase transition temperatures of phospholipid bilayers were measured as a function of relative humidity (RH) to better understand how the patterns of water vapor absorption and ..
  10. ncbi Prediction of TiO2 nanoparticle phase and shape transitions controlled by surface chemistry
    A S Barnard
    Center for Nanoscale Materials, Materials Science Division, Argonne National Laboratory, 9700 South Cass Ave, Argonne, Illinois 60439, USA
    Nano Lett 5:1261-6. 2005
    ..The latter introduces the possibility of inducing phase transitions by changing the surface chemistry...
  11. ncbi Relationship between the degree of conversion, solubility and salivary sorption of a hybrid and a nanofilled resin composite
    Eduardo Moreira da Silva
    Department of Restorative Dentistry, School of Dentistry, Federal Fluminense University, Niteroi, Rio de Janeiro, Brazil
    J Appl Oral Sci 16:161-6. 2008
    ..95). These findings suggest that nanofilled composites may present higher degradation in the oral environment than hybrid ones. Soft-start light-activation mode may increase the solubility of resin composites...
  12. ncbi First order magneto-structural phase transition and associated multi-functional properties in magnetic solids
    Sindhunil Barman Roy
    Magnetic and Superconducting Materials Section, Materials and Advanced Accelerator Sciences Division, Raja Ramanna Centre for Advanced Technology, Indore 452013, India
    J Phys Condens Matter 25:183201. 2013
    ..We highlight various characteristic features associated with a disorder influenced first order phase transition namely supercooling, superheating, phase-coexistence and metastability, in several magnetic materials and ..
  13. ncbi Electronic origin for the phase transition from amorphous Li(x)Si to crystalline Li15Si4
    Meng Gu
    Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington 99352, USA
    ACS Nano 7:6303-9. 2013
    ..In this paper, we report the fundamental characteristics of the phase transition of a-LixSi to c-Li15Si4 using in situ scanning transmission electron microscopy, electron energy loss ..
  14. pmc Sphingomyelin/phosphatidylcholine/cholesterol phase diagram: boundaries and composition of lipid rafts
    Rodrigo F M de Almeida
    Centro de Quimica Fisica Molecular, Instituto Superior Tecnico, Universidade Tecnica de Lisboa, Lisbon, Portugal
    Biophys J 85:2406-16. 2003
    ..The diagrams here described are used to rationalize literature results, some of them apparently discrepant, and to discuss lipid rafts within the framework of liquid-ordered/liquid-disordered phase coexistence...
  15. ncbi Quantitative CARS spectroscopy using the maximum entropy method: the main lipid phase transition
    Hilde A Rinia
    Swammerdam Institute for Life Sciences, University of Amsterdam, P O Box 94062, 1090 GB Amsterdam, The Netherlands
    Chemphyschem 8:279-87. 2007
    ..CARS) spectra is described in detail and applied to the time-resolved measurement of the main lipid phase transition of small, unilamellar 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) vesicles subject to a 3 min ..
  16. ncbi In situ TEM investigation of congruent phase transition and structural evolution of nanostructured silicon/carbon anode for lithium ion batteries
    Chong Min Wang
    Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington 99352, USA
    Nano Lett 12:1624-32. 2012
    ..We found the crystallization of Li(15)Si(4) from amorphous Li(x)Si is a spontaneous, congruent phase transition process without phase separation or large-scale atomic motion, which is drastically different from what is ..
  17. ncbi Influence of cholesterol on the phase transition of lipid bilayers: a temperature-controlled force spectroscopy study
    Lorena Redondo-Morata
    Institute for Bioengineering of Catalonia IBEC, Baldiri i Reixac 15 21, 08028, Barcelona, Spain
    Langmuir 28:12851-60. 2012
    ....
  18. ncbi Polarization transfer solid-state NMR for studying surfactant phase behavior
    Agnieszka Nowacka
    Physical Chemistry, POB 124, Lund University, SE 221 00 Lund, Sweden
    Langmuir 26:16848-56. 2010
    ..Replacing the succinate counterion with DNA prevents the formation of phases other than hexagonal and leads to a general increase of τ(c)...
  19. pmc Cancer as a dynamical phase transition
    Paul Cw Davies
    BEYOND Center for Fundamental Concepts in Science, Arizona State University, Tempe, AZ 85287 1504, USA
    Theor Biol Med Model 8:30. 2011
    ..A number of implications for preventative and therapeutic strategies are outlined...
  20. ncbi Conformational and hydrational properties during the L(beta)- to L(alpha)- and L(alpha)- to H(II)-phase transition in phosphatidylethanolamine
    Michael Rappolt
    Institute of Biophysics and Nanosystems Research, Austrian Academy of Sciences, Graz, Austria
    Chem Phys Lipids 154:46-55. 2008
    ..9 degrees C with an enthalpy of 28.5 kJ/mol and the lamellar-to-inverse hexagonal phase transition temperature, T(hex), at 61.6 degrees C with an enthalpy of 3.8 kJ/mol...
  21. ncbi Molecular self-assembly and patterning induced by sound waves. The case of gelation
    Giancarlo Cravotto
    Dipartimento di Scienza e Tecnologia del Farmaco, Universita di Torino, via P Giuria 9, I 10125 Torino, Italy
    Chem Soc Rev 38:2684-97. 2009
    ..Given the importance of supramolecular assemblies, especially hydrogels, as biomaterials and vehicles for drug transport and delivery, sound waves thus provide a facile entry to new forms of soft matter and functionalized materials...
  22. ncbi Conversion-dependent shrinkage stress and strain in dental resins and composites
    Jeffrey W Stansbury
    Department of Restorative Dentistry, University of Colorado Health Sciences Center, Aurora, CO 80045 0508, USA
    Dent Mater 21:56-67. 2005
    ..The complex, nonlinear correlation between conversion, shrinkage and stress are highlighted. A brief review of some of the materials-based approaches designed to minimize polymerization shrinkage and stress is also provided...
  23. ncbi Poly(N-isopropylacrylamide)-chitosan as thermosensitive in situ gel-forming system for ocular drug delivery
    Yanxia Cao
    College of Pharmacy, China Pharmaceutical University, Nanjing, PR China
    J Control Release 120:186-94. 2007
    ..5-400 microg/ml. These results suggest that PNIPAAm-CS is a potential thermosensitive in situ gel-forming material for ocular drug delivery, and it may improve the bio-availability, efficacy, and compliance of some eye drugs...
  24. ncbi Liquid-liquid phase transition in supercooled silicon
    Srikanth Sastry
    Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur Campus, Bangalore 560064, India
    Nat Mater 2:739-43. 2003
    ....
  25. pmc Sphingomyelin-cholesterol domains in phospholipid membranes: atomistic simulation
    Sagar A Pandit
    Department of Biological, Chemical, and Physical Sciences, Illinois Institute of Technology, Chicago, Illinois 60616, USA
    Biophys J 87:1092-100. 2004
    ..The calculated difference in thickness is consistent with data obtained in atomic force microscopy experiments...
  26. pmc Lipid lateral diffusion in ordered and disordered phases in raft mixtures
    Andrey Filippov
    Department of Biophysical Chemistry, Umea University, SE 901 87 Umea, Sweden
    Biophys J 86:891-6. 2004
    ..This means that on the millisecond timescale fluid, ordered domains are floating around in a sea of faster diffusing lipids, assigned to consist of mainly dioleoylphosphatidylcholine...
  27. pmc Comparison of DPPC and DPPG environments in pulmonary surfactant models
    Michael R Morrow
    Department of Physics and Physical Oceanography, Memorial University of Newfoundland, St John s, Newfoundland, Canada
    Biophys J 93:164-75. 2007
    ....
  28. ncbi Acute toxicity evaluation of biodegradable in situ gel-forming controlled drug delivery system based on thermosensitive PEG-PCL-PEG hydrogel
    Chang Yang Gong
    State Key Laboratory of Biotherapy, West China Hospital, and School of Life Science, Sichuan University, Chengdu 610041, China
    J Biomed Mater Res B Appl Biomater 91:26-36. 2009
    ..The results indicated that the prepared PECE hydrogel was nontoxic after intrapleural, intraperitoneal, or subcutaneous administration, and it could be a safe candidate for in situ gel-forming controlled drug delivery system...
  29. ncbi Indirect rapid prototyping of biphasic calcium phosphate scaffolds as bone substitutes: influence of phase composition, macroporosity and pore geometry on mechanical properties
    M Schumacher
    Friedrich Baur Research Institute for Biomaterials, University of Bayreuth, 95440, Bayreuth, Germany
    J Mater Sci Mater Med 21:3119-27. 2010
    ..This strength level is within and above the range of human cancellous bone. Therefore, this technique is well suited to manufacture scaffolds for bone tissue engineering...
  30. pmc Condensed complexes in vesicles containing cholesterol and phospholipids
    Arun Radhakrishnan
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Proc Natl Acad Sci U S A 102:12662-6. 2005
    ..Model calculations of phospholipid order parameters account for several features of the deuterium NMR spectra of labeled phospholipid molecules in bilayer mixtures with cholesterol...
  31. ncbi Structures of the I-, II- and H-methane clathrates and the ice-methane clathrate phase transition from quantum-chemical modeling with force-field thermal corrections
    Annika Lenz
    Department of Chemistry, IFM, Linköping University, SE 58183 Linköping, Sweden
    J Phys Chem A 115:6169-76. 2011
    ..The phase transition from MH-I to ice Ih and methane was computed and found to occur at about 9.7 MPa.
  32. ncbi Pair distribution function X-ray analysis explains dissolution characteristics of felodipine melt extrusion products
    K Nollenberger
    Evonik, Röhm GmbH, Kirschenallee, 64293 Darmstadt, Germany
    J Pharm Sci 98:1476-86. 2009
    ..We conclude that local ordering can be important to the release characteristics of extrudates, even when the components are present in the amorphous state...
  33. ncbi Size-dependent infrared phonon modes and ferroelectric phase transition in BiFeO3 nanoparticles
    Peng Chen
    Department of Chemistry, University of Tennessee, Knoxville, Tennessee 37996, United States
    Nano Lett 10:4526-32. 2010
    ..Taken together, these findings demonstrate the foundational importance of size effects for enhancing the rich functionality and broad utility of transition metal oxides...
  34. pmc Phase transition of nanotube-confined water driven by electric field
    Zhaoming Fu
    State Key Laboratory of Surface Physics, Key Laboratory for Computational Physical Sciences Ministry of Education, Department of Physics, Fudan University, Shanghai, People s Republic of China
    J Chem Phys 134:154507. 2011
    ..Furthermore, a discontinuous solid-solid phase transition is observed between pentagonal and helical ice nanotubes as the strengths of the external electric field ..
  35. pmc Large-scale fluid/fluid phase separation of proteins and lipids in giant plasma membrane vesicles
    Tobias Baumgart
    School of Applied and Engineering Physics and Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 104:3165-70. 2007
    ..Thus, GPMVs now provide an effective approach to characterize biological membrane heterogeneities...
  36. ncbi Comparison of two adaptive temperature-based replica exchange methods applied to a sharp phase transition of protein unfolding-folding
    Michael S Lee
    U S Army Research Laboratory, Computational Sciences and Engineering Branch, Aberdeen Proving Ground, Maryland 21005, USA
    J Chem Phys 134:244111. 2011
    ..Surprisingly, the current maximization method yielded a significantly lower transition temperature, in close agreement with experimental observation, likely due to more extensive sampling of the transition state...
  37. ncbi Paclitaxel-loaded Pluronic nanoparticles formed by a temperature-induced phase transition for cancer therapy
    Keun Sang Oh
    Department of Advanced Materials, Hannam University, 461 6 Jeonmin Dong, Yusung Gu, Daejeon 305 811, Republic of Korea
    J Control Release 148:344-50. 2010
    We prepared nanoparticles by a temperature-induced phase transition in a mixture of Pluronic F-68 and liquid PEG (polyethylene glycol, molecular weight: 400) containing paclitaxel (PTX) with a fast, simple, continuous and solvent-free ..
  38. ncbi Effect of temperature and moisture on the miscibility of amorphous dispersions of felodipine and poly(vinyl pyrrolidone)
    Patrick J Marsac
    Department of Industrial and Physical Pharmacy, School of Pharmacy, Purdue University, West Lafayette, Indiana 47907
    J Pharm Sci 99:169-85. 2010
    ..In conclusion, it appears that felodipine-PVP solid dispersions are susceptible to moisture-induced immiscibility when stored at a relative humidity >or=75%. In contrast, the solid dispersions remained miscible on heating...
  39. ncbi Onset of a quantum phase transition with a trapped ion quantum simulator
    R Islam
    Joint Quantum Institute, University of Maryland Department of Physics and National Institute of Standards and Technology, College Park, Maryland 20742, USA
    Nat Commun 2:377. 2011
    ..from paramagnetism to ferromagnetic order sharpens as the system is scaled up, prefacing the expected quantum phase transition in the thermodynamic limit...
  40. pmc Degree of conversion of nanofilled and microhybrid composite resins photo-activated by different generations of LEDs
    Benicia Carolina Iaskieviscz Ribeiro
    Dental School Prof Albino Coimbra Filho, Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil
    J Appl Oral Sci 20:212-7. 2012
    ..This study aimed at evaluating the degree of conversion (DC) of four composite resins, being one nanofilled and 3 microhybrid resins, photo-activated with second- and third-generation light-emitting diodes (LEDs)...
  41. ncbi Influence of lipid composition on the phase transition temperature of liposomes composed of both DPPC and HSPC
    Jun Chen
    College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, PR China
    Drug Dev Ind Pharm 39:197-204. 2013
    b>Phase transition of the lipid membrane is one of the most important properties of liposomes...
  42. ncbi Towards an understanding of the release behavior of temperature-sensitive liposomes: a possible explanation of the "pseudoequilibrium" release behavior at the phase transition temperature
    Xin Zhang
    Department of Chemical Engineering, Imperial College London, South Kensington Campus, London, UK
    J Liposome Res 23:167-73. 2013
    ..2000) maintain a constant permeability to ionic molecules when they are heated to the phase transition temperature of the membrane (Tm). However, DPPC:DSPE...
  43. pmc Metastability of anatase: size dependent and irreversible anatase-rutile phase transition in atomic-level precise titania
    Norifusa Satoh
    Photovoltaic Materials Unit, National Institute for Materials Science, Tsukuba, Ibaraki, Japan
    Sci Rep 3:1959. 2013
    ..To demonstrate the size dependence in anatase-rutile phase transition of titania, we used quantum-size titania prepared from the restricted number of titanium ions within ..
  44. ncbi Density-functional theory for f-electron systems: the α-γ phase transition in cerium
    Marco Casadei
    Fritz Haber Institut der Max Planck Gesellschaft, Faradayweg 4 6, D 14195 Berlin, Germany
    Phys Rev Lett 109:146402. 2012
    The isostructural α-γ phase transition in cerium is analyzed using density-functional theory with different exchange-correlation functionals, in particular the PBE0 hybrid functional and the exact-exchange plus correlation in the random-..
  45. ncbi Hydrostatic pressure effects on the lamellar to gyroid cubic phase transition of monolinolein at limited hydration
    T Y Dora Tang
    Department of Chemistry, Imperial College London, London, United Kingdom
    Langmuir 28:13018-24. 2012
    ..We discuss the qualitative effect of pressure, temperature, and water content on the stability of the Q(II)(G) phase...
  46. pmc Quantum simulation of thermally-driven phase transition and oxygen K-edge x-ray absorption of high-pressure ice
    Dongdong Kang
    Department of Physics, College of Science, National University of Defense Technology, Changsha 410073, Hunan, People s Republic of China
    Sci Rep 3:3272. 2013
    The structure and phase transition of high-pressure ice are of long-standing interest and challenge, and there is still a huge gap between theoretical and experimental understanding...
  47. ncbi Microwave induced shift of the main phase transition in phosphatidylcholine membranes
    Amerigo Beneduci
    Department of Chemistry, University of Calabria, Via P Bucci Cubo 17 D, 87036 Arcavacata di Rende CS, Italy
    Bioelectrochemistry 84:18-24. 2012
    ..point, microwaves induce a reduction of water ordering at the membrane interface, an upward shift of the main phase transition temperature and a broadening of the transition region...
  48. ncbi Phase transition induced fission in lipid vesicles
    C Leirer
    University of Augsburg, Experimental Physics I, D 86159 Augsburg, Germany
    Biophys Chem 143:106-9. 2009
    In this work we demonstrate how the first order phase transition in giant unilamellar vesicles (GUVs) can function as a trigger for membrane fission...
  49. ncbi Quantum phase transition from superparamagnetic to quantum superparamagnetic state in ultrasmall Cd(1-x)Cr(II)(x)Se quantum dots?
    Weiwei Zheng
    Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida 32306 4390, USA
    J Am Chem Soc 134:2172-9. 2012
    ..Surprisingly, a low-temperature phase transition is observed at 20 K that is believed to reflect the onset of long-range ordering of the single-domain DMSQD.
  50. ncbi The inverse hexagonal - inverse ribbon - lamellar gel phase transition sequence in low hydration DOPC:DOPE phospholipid mixtures
    Ben Kent
    Applied Physics, School of Applied Sciences, RMIT University, Melbourne, VIC 3000, Australia
    Chem Phys Lipids 157:56-60. 2009
    The inverse hexagonal to inverse ribbon phase transition in a mixed phosphatidylcholine-phosphatidylethanolamine system at low hydration is studied using small and wide angle X-ray scattering...
  51. ncbi SAXS investigation of a cubic to a sponge (L3) phase transition in self-assembled lipid nanocarriers
    Borislav Angelov
    Department of Chemistry and iNANO Interdisciplinary Nanoscience Centre, Aarhus University, 8000 Arhus, Denmark
    Phys Chem Chem Phys 13:3073-81. 2011
    ....
  52. ncbi Synthesis of a metal oxide with a room-temperature photoreversible phase transition
    Shin Ichi Ohkoshi
    Department of Chemistry, School of Science, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Nat Chem 2:539-45. 2010
    ..Here we report a photoreversible metal-semiconductor phase transition at room temperature with a unique phase of Ti(3)O(5), lambda-Ti(3)O(5)...
  53. ncbi Contribution of lysine-containing cationic domains to thermally-induced phase transition of elastin-like proteins and their sensitivity to different stimuli
    Won Bae Jeon
    Laboratory of Biochemistry and Cellular Engineering, Daegu Gyeongbuk Institute of Science and Technology, Daegu, Korea
    BMB Rep 44:22-7. 2011
    ..hydrophobic aggregates was monitored in order to determine the influence of cationic segments on phase transition properties as well as the sensitivity to changes in salt and pH...
  54. ncbi Phase behavior of an equimolar mixture of N-palmitoyl-D-erythro-sphingosine, cholesterol, and palmitic acid, a mixture with optimized hydrophobic matching
    Elana Brief
    Department of Physics, Simon Fraser University, Burnaby, British Columbia, Canada
    Langmuir 25:7523-32. 2009
    ..Therefore, it is inferred that, in SC, the chain heterogeneity is a stronger criteria for lipid miscibility than chain hydrophobic matching...
  55. ncbi Slow relaxation dynamics of water in hydroxypropyl cellulose-water mixture traces its phase transition pathway: a spectroscopic investigation
    Animesh Patra
    Unit for Nano Science and Technology, Department of Chemical Biological and Macromolecular Sciences, S N Bose National Centre For Basic Sciences, Block JD, Sector III, Salt Lake, Kolkata 700098, India
    J Phys Chem B 116:1508-16. 2012
    ..The observed results are correlated with a transition between the 'bulk' and 'bound' type of water molecules present in the system...
  56. ncbi Effect of ethanol, temperature, and gas flow rate on volatile release from aqueous solutions under dynamic headspace dilution conditions
    Maroussa Tsachaki
    Samworth Flavor Laboratory, Division of Food Sciences, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough LE12 5RD, United Kingdom
    J Agric Food Chem 56:5308-15. 2008
    ....
  57. pmc Phase transition in spin systems with various types of fluctuations
    Seiji Miyashita
    Department of Physics, The University of Tokyo, Japan
    Proc Jpn Acad Ser B Phys Biol Sci 86:643-66. 2010
    ..Generally, the so-called order-disorder phase transition takes place in competition between the interaction causing the system be ordered and the entropy causing a ..
  58. pmc Design of ultrasonically-activatable nanoparticles using low boiling point perfluorocarbons
    Paul S Sheeran
    Joint Department of Biomedical Engineering, The University of North Carolina and North Carolina State University, 304 Taylor Hall, CB 7575, Chapel Hill, NC 27599, USA
    Biomaterials 33:3262-9. 2012
    ..Results demonstrate the potential for low boiling point PFCs as a useful new class of compounds for activatable agents, which can be tailored to the desired application...
  59. ncbi Pressure effect on the bilayer phase transition of asymmetric lipids with an unsaturated acyl chain
    Kaori Tada
    Department of Biological Science and Technology, The University of Tokushima, Japan
    Ann N Y Acad Sci 1189:77-85. 2010
    ..Thermodynamic properties associated with the bilayer phase transition were discussed.
  60. ncbi Wurtzite to zinc blende phase transition in GaAs nanowires induced by epitaxial burying
    Gilles Patriarche
    Laboratoire de Photonique et de Nanostructures, CNRS, Marcoussis, France
    Nano Lett 8:1638-43. 2008
    ..We consider two possible mechanisms for the structural transition upon burying, examine how they can be discriminated from each other, and explain why the transition is favorable...
  61. ncbi Phase-change contrast agents for imaging and therapy
    Paul S Sheeran
    Joint Department of Biomedical Engineering, The University of North Carolina, Chapel Hill, 27599, USA
    Curr Pharm Des 18:2152-65. 2012
    ..Factors that influence the design of PCCAs are discussed, as well as the need for future studies to characterize potential bioeffects for administration in humans and optimization of ultrasound parameters...
  62. pmc Hierarchies of networked phases induced by multiple liquid-liquid critical points
    Chia Wei Hsu
    Department of Physics, Wesleyan University, Middletown, CT 06459, USA
    Proc Natl Acad Sci U S A 105:13711-5. 2008
    ..The concept of network interpenetration helps to explain the generation of multiple liquid phases in single-component systems, suggested to occur in some atomic and molecular network-forming fluids, including water and silica...
  63. ncbi Blood-pool multifunctional nanoparticles formed by temperature-induced phase transition for cancer-targeting therapy and molecular imaging
    Keun Sang Oh
    Center for Theragnosis, Biomedical Research Center, Korea Institute of Science and Technology, Hwarangno 14 gil 5, Seongbuk gu, Seoul 136 791, Republic of Korea
    Int J Pharm 437:192-202. 2012
    Multifunctional nanoparticles (NPs) were prepared based on temperature-induced phase transition in a molten mixture of Lipiodol(®), Tween 80, paclitaxel (PTX), and Pluronic F-68, wherein the Lipiodol(®)/Tween 80 mixture is used as a ..
  64. ncbi Single-molecule study of the DNA denaturation phase transition in the force-torsion space
    D Salerno
    Dipartimento di Medicina Sperimentale, Universita degli Studi di Milano Bicocca, Via Cadore 48, Monza MB 20900, Italy
    Phys Rev Lett 109:118303. 2012
    ..The model correctly describes the position of the denaturation regions, the transition boundaries, and the measured values of the DNA extension fluctuations...
  65. ncbi Impact of phase transition on the mouse oocyte spindle during vitrification
    Ching Chien Chang
    Reproductive Biology Associates, Atlanta, GA, USA
    Reprod Biomed Online 22:184-91. 2011
    During vitrification, the glass-like solidification is the phase-transition process from liquid to solid. Phase transition is one of the major factors suspected to affect the physiology of the oocyte, such as the structure of the meiotic ..
  66. ncbi Stratum corneum hydration: phase transformations and mobility in stratum corneum, extracted lipids and isolated corneocytes
    C L Silva
    Faculdade de Farmacia, Universidade de Coimbra, 3004 535, Coimbra, Portugal
    Biochim Biophys Acta 1768:2647-59. 2007
    ..v) The hydration causes swelling in the corneocytes, while it does not affect the mobility of solid components (keratin filaments)...
  67. ncbi Size-dependent structural transformations of hematite nanoparticles. 1. Phase transition
    I V Chernyshova
    The Center for NanoBioEarth, Department of Geosciences, Virginia Tech, Blacksburg, VA 24061, USA
    Phys Chem Chem Phys 9:1736-50. 2007
    ..The critical size for the onset of the alpha-->gamma phase transition depends on the particle environment, and for the dry particles used in this study is about 40 nm...
  68. ncbi Diisopropylammonium chloride: a ferroelectric organic salt with a high phase transition temperature and practical utilization level of spontaneous polarization
    Da Wei Fu
    Ordered Matter Science Research Center, Southeast University, Nanjing, 211196, P R China
    Adv Mater 23:5658-62. 2011
    A simple organic salt, diisopropylammonium chloride, shows the highest ferroelectric phase transition temperature among molecule-based ferroelectrics with a large spontaneous polarization, making it a candidate for practical technological ..
  69. pmc Changes in single K(+) channel behavior induced by a lipid phase transition
    Heiko M Seeger
    Centro S3, CNR Istituto Nanoscienze, Modena, Italy
    Biophys J 99:3675-83. 2010
    ....
  70. ncbi Pressure-induced shape change of phospholipid vesicles: implication of compression and phase transition
    J M Perrier-Cornet
    Laboratoire de Genie des Procedes Alimentaires et Biotechnologiques, E N S B A N A, 1, Esplanade Erasme, 21000 Dijon, France
    J Membr Biol 204:101-7. 2005
    ..The thermotropic main phase transition (L alpha to P beta') of the different vesicles prepared was determined under pressure through a ..
  71. ncbi A peculiar phase transition of plasmalogen bilayer membrane under high pressure
    Agnieszka Broniec
    Department of Biophysics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30 387 Krakow, Poland
    Langmuir 25:11265-8. 2009
    The bilayer phase transition of plasmalogen, monounsaturated plasmenylcholine 1-O-1'-(Z)-octadecenyl-2-oleoyl-sn-glycero-3-phosphocholine (Plg-SOPC), was examined by differential scanning calorimetry, high-pressure transmittance, and ..
  72. pmc Chemical and mechanical impact of silica nanoparticles on the phase transition behavior of phospholipid membranes in theory and experiment
    C Westerhausen
    Experimental Physics I, Institute of Physics and Augsburg Center for Innovative Technologies, Augsburg, Germany
    Biophys J 102:1032-8. 2012
    ..We demonstrate that silica NPs have at least two independent effects on the phase transition of phospholipid membranes: 1), a chemical effect resulting from the finite instability of the NPs in water; ..
  73. ncbi Thermal decomposition of struvite and its phase transition
    M Iqbal H Bhuiyan
    University of British Columbia, Department of Civil Engineering, Environmental Engineering Group, Vancouver, BC, Canada V6T 1Z4
    Chemosphere 70:1347-56. 2008
    ..It was transformed into monohydrate, dittmarite by losing its five water molecules of crystallization, when boiled in excess water...
  74. ncbi Stoichiometry engineering of monoclinic to rutile phase transition in suspended single crystalline vanadium dioxide nanobeams
    Shixiong Zhang
    Department of Materials Science and Engineering, Northwestern University, Evanston, Illinois 60208, United States
    Nano Lett 11:1443-7. 2011
    ..the rutile phase to temperatures as low as 103 K, which represents an unprecedented suppression of the phase transition by 238 K...
  75. ncbi Porous bioactive nanostructured scaffolds for bone regeneration: a sol-gel solution
    Oliver Mahony
    Imperial College London, Department of Materials, South Kensington Campus, London, SW7 2AZ, UK
    Nanomedicine (Lond) 3:233-45. 2008
    ..Composites provide a partial solution to this problem, although their bioactive and degradation properties are not ideal, therefore novel nanocomposites are needed. The route to these potentially ideal materials is described...
  76. ncbi Ferroelectric phase transition in individual single-crystalline BaTiO3 nanowires
    Jonathan E Spanier
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Nano Lett 6:735-9. 2006
    We report scanned probe characterizations of the ferroelectric phase transition in individual barium titanate (BaTiO3) nanowires...
  77. ncbi Soft perforation of planar bilayer lipid membranes of dipalmitoylphosphatidylcholine at the temperature of the phase transition from the liquid crystalline to the gel state
    Valerij F Antonov
    Department of Medical and Biological Physics, Sechenov Moscow Medical Academy, Russia
    Eur Biophys J 34:155-62. 2005
    ..structural rearrangement of the lipid bilayer formed from disaturated phospholipids at the temperature of the phase transition from the liquid crystalline state to the gel state...
  78. ncbi Thermally reversible in situ gelling carbamazepine liquid suppository
    Amal El-Kamel
    Department of Pharmaceutics, Faculty of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia
    Drug Deliv 13:143-8. 2006
    ..9 and 18.8 micro g x h/ml, respectively. These results suggested that mucoadhesive in situ gelling liquid suppository could be an effective and convenient delivery system of carbamazepine...
  79. ncbi Phase transition in random catalytic networks
    Rudolf Hanel
    Institute of Physics, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium
    Phys Rev E Stat Nonlin Soft Matter Phys 72:036117. 2005
    ..For a fixed density of rules we can demonstrate the existence of a phase transition from a practically unpopulated regime to a fully populated and diverse one...
  80. pmc Morphological behavior of lipid bilayers induced by melittin near the phase transition temperature
    Shuichi Toraya
    Graduate School of Engineering, Yokohama National University, Yokohama 240 8501, Japan
    Biophys J 89:3214-22. 2005
    ..bilayers containing melittin (lecithin/melittin molar ratio of 10:1) around the gel-to-liquid crystalline phase transition temperatures (Tc) were examined by a variety of biophysical methods...
  81. ncbi Neat DODAB vesicles: Effect of sonication time on the phase transition thermodynamic parameters and its relation with incomplete chain freezing
    R O Brito
    Centro de Investigacao em Quimica, Department of Chemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre 687, P 4169 007 Porto, Portugal
    Chem Phys Lipids 137:18-28. 2005
    ..are found in the literature for the thermodynamic parameters of the gel-to-liquid crystal (gel-lc) phase transition of these vesicles...
  82. pmc Detergents destabilize the cubic phase of monoolein: implications for membrane protein crystallization
    Y Misquitta
    Biophysics, The Ohio State University, Columbus, Ohio 43210, USA
    Biophys J 85:3084-96. 2003
    ..These effects have important implications for in meso crystallization. A diffraction-based method for assaying detergents is presented...
  83. pmc Lessons of slicing membranes: interplay of packing, free area, and lateral diffusion in phospholipid/cholesterol bilayers
    Emma Falck
    Laboratory of Physics and Helsinki Institute of Physics, Helsinki University of Technology, Helsinki, Finland and Wihuri Research Institute, Helsinki, Finland
    Biophys J 87:1076-91. 2004
    ..Summarizing, our results highlight the central role of free area in comprehending the structural and dynamic properties of membranes containing cholesterol...
  84. ncbi Characterization of liposomal tacrolimus in lung surfactant-like phospholipids and evaluation of its immunosuppressive activity
    Olga Cañadas
    Department of Biochemistry and Molecular Biology I, Complutense University of Madrid, 28040 Madrid, Spain
    Biochemistry 43:9926-38. 2004
    ..FK506 hardly affected the transition enthalpy, the T(m), and cooperativity of the phase transition of DPPC and DPPC/POPG vesicles as determined by differential scanning calorimetry and steady-state 1,6-..
  85. pmc Effects of cholesterol on physical properties of human erythrocyte membranes: impact on susceptibility to hydrolysis by secretory phospholipase A2
    Anne L Heiner
    Department of Physiology and Developmental Biology, Brigham Young University, Provo, Utah 84602, USA
    Biophys J 94:3084-93. 2008
    ..It is also proposed that the high level of cholesterol in erythrocyte membranes is a protective mechanism to guard against hydrolytic enzymes...
  86. ncbi Phase transition kinetics of lipid bilayer membranes studied by time-resolved pressure perturbation calorimetry
    Martin Schiewek
    Faculty of Chemistry and Physics, Institute of Chemistry, Martin Luther University Halle Wittenberg, Muehlpforte 1, 06108, Halle Saale, Germany
    Eur Biophys J 39:815-24. 2010
    ..with the instrumental response function gives information about slow processes connected with the lipid phase transition. The lipid transition from the gel to the liquid-crystalline state was found to be a multi-step process with ..
  87. ncbi Effect of the antibiotic azithromycin on thermotropic behavior of DOPC or DPPC bilayers
    N Fa
    Unité de Pharmacologie Cellulaire et Moléculaire, Universite Catholique de Louvain, 73 70 Avenue E Mounier 73, B 1200 Brussels, Belgium
    Chem Phys Lipids 144:108-16. 2006
    ..For both lipids, the enthalpy associated with the phase transition is strongly decreased with azithromycin...
  88. ncbi Molecular studies of the gel to liquid-crystalline phase transition for fully hydrated DPPC and DPPE bilayers
    Sukit Leekumjorn
    Virginia Polytechnic Institute and State University, Department of Chemical Engineering, Blacksburg VA 24061, USA
    Biochim Biophys Acta 1768:354-65. 2007
    ..a comprehensive study of the structural properties of saturated lipid bilayers, DPPC and DPPE, near the main phase transition. Though the chemical structure of DPPC and DPPE are largely similar (they only differ in the choline and ..
  89. pmc Transbilayer effects of raft-like lipid domains in asymmetric planar bilayers measured by single molecule tracking
    Volker Kiessling
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, 22908 0736, USA
    Biophys J 91:3313-26. 2006
    ....
  90. pmc Low amounts of sucrose are sufficient to depress the phase transition temperature of dry phosphatidylcholine, but not for lyoprotection of liposomes
    Constança Cacela
    Max Planck Institut fur Molekulare Pflanzenphysiologie, D 14424 Potsdam, Germany
    Biophys J 90:2831-42. 2006
    ..been proposed that the lyoprotection of liposomes depends on the depression of the gel to liquid-crystalline phase transition temperature (T(m)) of the dry membranes below ambient and on the prevention of membrane fusion by sugar glass ..
  91. pmc Temperature dependence of structure, bending rigidity, and bilayer interactions of dioleoylphosphatidylcholine bilayers
    Jianjun Pan
    Department of Physics, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    Biophys J 94:117-24. 2008
    ....
  92. ncbi Comparison between protein-polyethylene glycol (PEG) interactions and the effect of PEG on protein-protein interactions using the liquid-liquid phase transition
    Ying Wang
    Department of Chemistry, Texas Christian University, Fort Worth, Texas 76129, USA
    J Phys Chem B 111:1222-30. 2007
    ..Finally, due to the general importance of LLPS, we will experimentally show that protein-PEG-buffer mixtures can exhibit two distinct types of liquid-liquid phase transitions...
  93. pmc Calorimetric, x-ray diffraction, and spectroscopic studies of the thermotropic phase behavior and organization of tetramyristoyl cardiolipin membranes
    Ruthven N A H Lewis
    Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada
    Biophys J 92:3166-77. 2007
    ..data indicate that the lower temperature transition corresponds to a lamellar subgel (L(c)') to gel (L(beta)) phase transition and the higher temperature endotherm to a L(beta) to lamellar liquid-crystalline (L(alpha)) phase transition...
  94. pmc Sphingomyelin structure influences the lateral diffusion and raft formation in lipid bilayers
    Andrey Filippov
    Department of Biophysical Chemistry, Umea University, Umea, Sweden
    Biophys J 90:2086-92. 2006
    ..The results indicate that a crucial element in the domain-forming process is the formation of highly packed bilayers of SM and cholesterol rather than specific interactions between SM and cholesterol...
  95. pmc Temperature and composition dependence of the interaction of delta-lysin with ternary mixtures of sphingomyelin/cholesterol/POPC
    Antje Pokorny
    Department of Chemistry and Biochemistry, University of North Carolina Wilmington, Wilmington, NC, USA
    Biophys J 91:2184-97. 2006
    ..These results were combined with differential scanning calorimetry to obtain the BSM/Chol/POPC phase diagram as a function of temperature...
  96. pmc Calcium triggered L alpha-H2 phase transition monitored by combined rapid mixing and time-resolved synchrotron SAXS
    Anan Yaghmur
    Institute of Biophysics and Nanosystems Research, Austrian Academy of Sciences, Graz, Austria
    PLoS ONE 3:e2072. 2008
    ....
  97. ncbi Structure of fully hydrated fluid phase lipid bilayers with monounsaturated chains
    Norbert Kucerka
    Physics Department, Carnegie Mellon University, Pittsburgh, Pennsylvania, 15213, USA
    J Membr Biol 208:193-202. 2005
    ..Our results suggest that lipids with one monounsaturated chain have quantitative bilayer structures closer to lipids with two monounsaturated chains than to lipids with two completely saturated chains...
  98. ncbi Surface dilational rheology of mixed beta-lactoglobulin/surfactant layers at the air/water interface
    R Miller
    Max Planck Institut fur Kolloid und Grenzflachenforschung, Am Muhlenberg 1, 14424 Potsdam, Germany
    J Phys Chem B 109:13327-31. 2005
    ....
  99. ncbi How principles of domain formation in model membranes may explain ambiguities concerning lipid raft formation in cells
    Erwin London
    Department of Biochemistry and Cell Biology, Stony Brook University, S U N Y, Stony Brook, NY 11794 5215, USA
    Biochim Biophys Acta 1746:203-20. 2005
    ..Very high concentrations of membrane cholesterol and proteins may explain key physical characteristics of domains in cellular membranes, and are the two of the most obvious factors requiring additional study...
  100. pmc Insight into the putative specific interactions between cholesterol, sphingomyelin, and palmitoyl-oleoyl phosphatidylcholine
    Jussi Aittoniemi
    Laboratory of Physics and Helsinki Institute of Physics, Helsinki University of Technology, Helsinki, Finland
    Biophys J 92:1125-37. 2007
    ..This implies improved Chol-induced ordering of PSM's chains over POPC's chains. These findings are discussed in the context of the hydrophobic mismatch concept suggested recently...
  101. pmc A thermally induced phase transition in a viral capsid transforms the hexamers, leaving the pentamers unchanged
    James F Conway
    Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA
    J Struct Biol 158:224-32. 2007
    ..Pentamers, on the other hand, are more stably anchored and resist this thermal perturbation...

Research Grants63

  1. Intracellular Phase Diagram Creation Using a Micro-Differential Scanning Calorime
    GARY L SOLBREKKEN; Fiscal Year: 2010
    ..building a micro-scale differential scanning calorimeter ([unreadable]DSC) that is capable of detecting the phase transition of a single cell in media...
  2. Agnoprotein in JC virus virion biogenesis and replication
    Mahmut Safak; Fiscal Year: 2012
    ..It deregulates cell cycle progression, in which agnoprotein positive cells largely accumulate at G2/M phase transition. We also demonstrated the involvement of the coding region of agnoprotein in regulation of JCV life cycle by ..
  3. C/EBP beta SIGNALS HEPATOCYTE PROLIFERATION AND SURVIVAL
    Mario Chojkier; Fiscal Year: 2012
    ..We have established that C/EBP(3 affects the GI/S phase transition of the cell cycle...
  4. Replication licensing and cell cycle checkpoints
    Jeanette Gowen Cook; Fiscal Year: 2013
    ..is stimulated by the activity of cyclin dependent protein kinases (Cdks) that are activated at the G1/S phase transition and remain active until mitosis...
  5. MOUSE MODELS TO STUDY GONADAL TUMOR DEVELOPMENT
    Martin M Matzuk; Fiscal Year: 2010
    ..is that the inhibin/activin/BMP, RB/E2F, FSH, LH, and cell cycle pathways converge to regulate the G1 to S phase transition and that modulation of the activity (phosphorylation) state of RB by cell cycle regulators (e.g...
  6. Mechanistic regulation of tumor specific forms of cyclin E in breast cancer
    NIKKI A DELK; Fiscal Year: 2010
    ..Cyclin E, a cell cycle protein that mediates GO release and G1 to S phase transition, shows a unique tumor-specific deregulation associated with malignancy in breast, ovarian, and colorectal ..
  7. Protease Operated Depot for Delivery of GLP-1
    Ashutosh Chilkoti; Fiscal Year: 2013
    ..experience in biomaterials development of recombinant ELP-based biopolymers that can be designed to undergo a phase transition in vivo, driven by body heat to form a highly viscous coacervate with long retention upon injection...
  8. Molecular Mechanisms that Regulate Phase Transition in Dimorphic Fungi
    Gregory M Gauthier; Fiscal Year: 2010
    ..the pivotal role of morphogenesis in pathogenesis of these infections, the mechanisms that regulate the phase transition are poorly understood...
  9. Molecular Mechanisms of Impaired DAN Damage Response in Leukemia Pathogenesis
    James J D Hsieh; Fiscal Year: 2012
    ..MLL not only assists in the G1/S and G2/M phase transition during a normal cell division cycle but also executes the S-phase checkpoint upon DNA damage...
  10. Molecular Mechanisms of Impaired DAN Damage Response in Leukemia Pathogenesis
    James J D Hsieh; Fiscal Year: 2013
    ..MLL not only assists in the G1/S and G2/M phase transition during a normal cell division cycle but also executes the S-phase checkpoint upon DNA damage...
  11. Image-guided Ultrasound-triggered Tumor Therapy
    Alexander L Klibanov; Fiscal Year: 2011
    ..Evaluate release efficacy as a function of liposome/particle membrane composition, structure, phase transition temperature and ultrasound intensity, frequency and pulse characteristics to achieve optimal release. 2...
  12. Cell Cycle Regulation of Histone Gene Expression
    Gary S Stein; Fiscal Year: 2013
    ..The controlled activation of histone gene expression at the G1/S phase transition is essential for chromatin packaging of nascent DNA...
  13. Contractile Hydrogel Dressing for Primary Wound Closure
    Aristidis Veves; Fiscal Year: 2010
    ..we may further improve the basic contractile hydrogel dressing technology platform by including hydrogel phase transition triggered slow release of growth factors, antimicrobials and mmp inhibitors...
  14. A Thermo-responsive Biopharmaceutical to Enhance the Tear Production of Lacritin
    Sandeep Samudre; Fiscal Year: 2013
    ..ELPs are repeated pentameric peptides, (VPGXG)n, that have characteristic inverse phase transition temperatures, Tt, above which they phase separate from aqueous solution...
  15. Local Radionuclide Delivery to Solid Tumors by Injectible Biopolymer
    Wenge Liu; Fiscal Year: 2013
    ..Thermally sensitive elastin-like polypeptides (ELPs) that spontaneously undergo a soluble-insoluble phase transition between room temperature and body temperature leading to the formation of a coacervate, "gel-like" phase will ..
  16. Role of Histone H2B Ubiquitylation in DNA Replication
    KELLY MIGUEL TRUJILLO; Fiscal Year: 2013
    ..that the MCM helicase falls off the template in htb-K123R cells that cannot be ubiquitylated at the G1-S phase transition. In the first specific aim, I propose to identify the precise replication steps that are dependent on H2Bub1...
  17. Stimuli Responsive Topical Gels for Mechanically Assisted Wound Debridement
    Aristidis Veves; Fiscal Year: 2010
    ..characterize wound debridement gels, (2) develop a comprehensive theoretical model to explain the gel volume phase transition, (3) perform ex- vivo cytotoxicity evaluation to demonstrate the biocompatible nature of the gels, and (4) ..
  18. Multiplex Nanocarrier-based Hydrogels for Prevention of Vaginal HIV Transmission.
    Patrick J Sinko; Fiscal Year: 2012
    ..upon instillation allowing for high vaginal dispersion/mucosal coverage where it then undergoes a rapid phase transition to form a visco-elastic gel...
  19. The role of Cyclin E in growth control and tumorogenesis
    Steven I Reed; Fiscal Year: 2013
    ..by applicant): Cyclin E, an activator of cyclin-dependent kinase 2 (Cdk2) is a positive activator of the G1-S phase transition in proliferating mammalian cells and therefore serves an important function during development and in ..
  20. The Role of pRB and Co-repressors in Transcriptional Regulation
    Brian D Dynlacht; Fiscal Year: 2013
    ..It is also unclear what transcriptional controls distinguish cells progressing through the M/G1 phase transition from those observed in cells re-emerging from growth arrest (the G0/G1 phase transition) and how differences ..
  21. Pak1 Signaling and Targets in Breast Cancer Progression
    Rakesh Kumar; Fiscal Year: 2013
    ..test the hypothesis that E2F1 and HSF1 transcriptional factors are determinants of Pak1 functions at the G1/S phase transition and during mitosis using functionally relevant, genetic mouse models...
  22. Smart Packaging: A Novel Technique for Localized Drug Delivery for Ovarian Cancer
    Eva Christabel Williams; Fiscal Year: 2012
    ..system is a clear viscous solution, which, upon injection (at contact with warm tissue, 37:C) undergoes a phase transition to a semi-solid gel...
  23. Mechanism of HTLV-1 Tax-mediated activation of CDK6 transcription.
    ISABELLE MICHELE LEMASSON; Fiscal Year: 2010
    ..Cdk6 is a positive regulator of the G1- to S-phase transition and maintains cells in a state of proliferation...
  24. Dynamics of cellular senescence in single human cells
    Jeremy Purvis; Fiscal Year: 2012
    ..This three-phase transition plan will illuminate our basic understanding of cellular senescence and provide an extensible computational/..
  25. Nonlinear Imaging Methods for High-Throughput Protein and Drug Screening
    John C Conboy; Fiscal Year: 2012
    ..Examination of the influence of drugs on the thermotropic phase transition and phase behavior of lipid membranes by IR-Vis SFG spectroscopy and IR- Vis SFG high-throughput imaging is ..
  26. REGULATION OF P53 IN CERVICAL CARCINOMA BY HEAT/HYPOXIA
    Amato Giaccia; Fiscal Year: 1999
    ..cell proliferation or through the loss of negative growth regulators such as p53 and Rb that modulate a G1/S-phase transition. In addition to aberrant cell gene products, viral oncogene products such as the human papillomavirus E6 and ..
  27. Dynamics of cellular senescence in single human cells
    Jeremy Purvis; Fiscal Year: 2013
    ..This three-phase transition plan will illuminate our basic understanding of cellular senescence and provide an extensible computational/..
  28. TESTOSTERONE REPLACEMENT & PHYSICAL FUNCTION IN HIV+MEN
    Shalender Bhasin; Fiscal Year: 2005
    ..mass; we will determine whether testosterone supplementation increases satellite cell number by promoting G:S phase transition, thus inducing satellite cells to enter the cell cycle or by inhibiting satellite cell apoptosis...
  29. ELASTIN FUSION PROTEINS
    Ashutosh Chilkoti; Fiscal Year: 2012
    ..fusion proteins by introducing a greater level of sophistication beyond simple physical triggers of the ELP phase transition and uncontrolled aggregation as the final state, by developing new strategies for the: (1) stimulus ..
  30. Jun Kinase Signaling and Apoptosis in Ischemia Stroke
    Chia Yi Kuan; Fiscal Year: 2006
    ..The cellular mechanisms that may abolish the G1/S-phase transition block in cerebral ischemia will be examined...
  31. A novel vaccine/adjuvant for Streptococcus pneumoniae
    M A Westerink; Fiscal Year: 2003
    ..F127-based matrices are characterized by reverse thermogelation, a feature that allows a phase transition from liquid to gel upon reaching physiological temperatures...
  32. Monoclonal antibodies to inhibit Aspergillus germination
    MARTA L FELDMESSER; Fiscal Year: 2010
    ..interactions in invasive aspergillosis using a monoclonal antibody (MAb 318) that inhibits germination, the phase transition from the spore form to hyphal form that is required for invasion, and prolongs survival in mice with invasive ..
  33. GLUCOSE SENSITIVE MEMBRANES IN THE DELIVERY OF INSULIN
    THOMAS HORBETT; Fiscal Year: 1992
    ..To enhance sensitivity, preparation and analysis of "phase transition" polymers that undergo large changes in swelling over narrow pH intervals will be done in year 1...
  34. INTERMEDIATES AND TRANSBILAYER PEPTIDES
    Martin Caffrey; Fiscal Year: 2001
    ..fusion intermediates exist under special circumstances in systems undergoing the bilayer/inverted hexagonal phase transition. In this study Dr...
  35. BIOMIMETIC HYDROGELS FOR BONE REGENERATION
    KEVIN HEALY; Fiscal Year: 2004
    ..acid) hydrogels that are extremely pliable and fluid-like at room temperature (RT), but demonstrate a phase transition as the matrix warms from RT to body temperature, yielding more rigid structures...
  36. REVERSIBLE GELS FOR DELIVERY OF MEDICAL RADIOISOTOPES
    Anna Gutowska; Fiscal Year: 2000
    ..The unique aspect of this novel system is that at body temperature the polymer will undergo a phase transition resulting in entrapment of the radionuclide within the thermally reversible gel matrix and at room ..
  37. Swellable Templated Copolymers
    RUDOLF SEITZ; Fiscal Year: 2006
    ..The rest is N-isopropylacrylamide or n-propylacrylamide. This polymer undergoes a thermal phase transition, coming out of solution above the thermal phase transition temperature...
  38. LIPID PHASE TRANSITIONS AND PLATELET ACTIVATION
    Fern Tablin; Fiscal Year: 2001
    ..of human platelets has recently been shown to be associated with platelets passing through a thermotropic phase transition. This proposal has the long-term objective of developing mechanisms of stabilizing platelets during and after ..
  39. EFFECTS OF PRESSURE ON MEMBRANE-COMPONENT INTERACTIONS
    Suzanne Scarlata; Fiscal Year: 1992
    ..the stability of charged vesicles under pressure will be established by monitoring the gel to liquid crystal phase transition temperature with fluorescent probes...
  40. HYPERTHERMIA AND PERFUSION EFFECTS IN CANCER THERAPY
    Mark Dewhirst; Fiscal Year: 2009
    ..drugs, particularly with novel thermolabile liposomes that release contents within seconds of reaching their phase transition temperature, (3) conduct phase III trials comparing best conventional therapy q HT, (4) examine whether ..
  41. VIP RECEPTOR SECOND MESSENGERS IN PANCREATIC CANCER
    CHARLES ULRICH; Fiscal Year: 2002
    ..tyrosine kinase receptor (TKR)-induction of mitogen-activated protein kinases, TKR-stimulated G1 yields S phase transition, and subsequent progression of neoplastcic pancreatic duct cells through G2/M...
  42. Image-guided Ultrasound-triggered Tumor Therapy
    Alexander Klibanov; Fiscal Year: 2007
    ..Evaluate release efficacy as a function of liposome/particle membrane composition, structure, phase transition temperature and ultrasound intensity, frequency and pulse characteristics to achieve optimal release. 2...
  43. RAS GENE FUNCTION IN FUNGAL DIMORPHISM
    JUDITH MEDOFF; Fiscal Year: 1990
    ..capsulatum is nonpathogenic and only the yeast phase is parasitic, factors which control the phase transition are critical for understanding pathogenicity. H...
  44. ANTIATHEROGENIC ACTIONS OF OMEGA-3 FATTY ACIDS
    Papasani Subbaiah; Fiscal Year: 1990
    ..changes we have already shown in lipoproteins modify their physicochemical characteristics (size, phase transition temperature, subpopulation distribution, fluidity), and functional properties (the LDL catabolic pathways, ..
  45. AFGPS AND PLATELET MEMBRANE STABILIZATION
    Fern Tablin; Fiscal Year: 2001
    ..activation of human platelets is associated with the passage of the platelets through their thermotropic phase transition. Anti-freeze glycoproteins (AFGPs) from the blood of certain Arctic and Antarctic fishes are capable of ..
  46. MEMBRANE SURFACE PRESSURE--MEASUREMENT AND SIGNIFICANCE
    Robert MacDonald; Fiscal Year: 1992
    ..to Goal I will be to vary the surface pressure until monolayer and bilayer correspond with respect to phase transition temperature, 2-dimensional diffusion coefficient and partition coefficient of a hydrophobic probe...
  47. Characterization of the DNA replication protein Sid2p
    Elizabeth Vallen; Fiscal Year: 2002
    ..This may allow elucidation of the role of CDK regulation at the G1/S phase transition. Further analysis of the role of SID2 will focus on molecular, genetic and biochemical characterization of ..
  48. Cables role in endometrial differentiation and cancer
    Bo Rueda; Fiscal Year: 2007
    ..Cdk2 regulates the G1 S-phase transition of the cell cycle and cdk2 tyrosine phosphorylation is inhibitory and leads to decreased cdk2 activity and ..
  49. Synthetic vectors for pH-targeted gene delivery
    David Oupicky; Fiscal Year: 2006
    ..copolymers of N-isopropylacrylamide and 1-vinylimidazole, which display pH-induced globule-to-coil phase transition at body temperature, will be synthesized by RAFT polymerization, conjugated with PEG, protamine, and ..
  50. VASCULAR BUBBLE GENERATION FOR DIAGNOSIS AND THERAPY
    PAUL CARSON; Fiscal Year: 2001
    ..by vaporization of perfluorocarbon droplets will be pursued, with attention to physical factors controlling phase transition, size and dissolution...
  51. Low Cost Production of Recombinant Proteins
    SUSAN DAGHER; Fiscal Year: 2007
    ..and peptides fused to an ELP retain the environmentally triggered (temperature, salt) soluble-insoluble phase transition behavior of ELPs, and that this reversible phase transition can be carried out in cell lysate to separate ELP ..
  52. DRUGS OF ABUSE EFFECTS ON BEHAVIORAL ORGANIZATION
    Martin Paulus; Fiscal Year: 1999
    ..Analogies to statistical mechanics will be used to adapt the notion of a phase transition to behavior and to classify phase transitions in behavior...
  53. FEASIBILTITY OF PRECLINICAL SCALEUP OF LIPOSOMAL TNF
    ALAN HAYMAN; Fiscal Year: 1992
    ..This feasibility study should facilitate compliance with quality control measures likely to be requested by the FDA in future pre- IND discussions...
  54. New Algorithms for Modeling Flexibility in Proteins
    Michael Thorpe; Fiscal Year: 2005
    ..theory will be incorporated to simulate the processes of protein folding and unfolding and to examine the phase transition behavior...
  55. FoxM1 in Hepatocytes During Liver Repopulation
    Xin Wang; Fiscal Year: 2007
    ..As a key cell-cycle regulator of both G1/S phase transition and G2/M transition, the mammalian Forkhead Box M1 (FoxM1) protein is chosen in this application to improve ..
  56. Smart DeltaPhase Tags for Purification of Recombinant Peptides
    SUSAN DAGHER; Fiscal Year: 2006
    ..triggered (temperature, salt) soluble-insoluble phase transion behavior of ELPs, and that this reversible phase transition can be carried out in cell lysate to separate ELP fusions from other cellular proteins to homogeneity by a ..
  57. Selenium molecular signaling in human prostate cancer
    Clement Ip; Fiscal Year: 2007
    ..Additionally, selenium also decreased the expression of genes involved in S phase transition, DNA synthesis and mitosis...
  58. Function and regulation of cyclin E-Cdk2 substrate NPAT
    Jiyong Zhao; Fiscal Year: 2007
    ..To understand how cyclin E-Cdk2, a key CDK required for the G1-to-S phase transition, executes its function in vivo, we developed a strategy to isolate potential cyclin E-Cdk2 substrates and ..
  59. Regulation of the Lymphocytic cell cycle by E2F
    James DeGregori; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): E2F activity is critical for the control of the G1 to S phase transition, and the pathway leading to E2F activation is deregulated in most human tumors...
  60. HEPATIC FIBROSIS: MOLECULAR MECHANISMS
    Mario Chojkier; Fiscal Year: 2009
    ..C/EBP)(, and we have established that C/EBP( is a critical modulator of both gene expression and the G1/S phase transition of the cell cycle...
  61. Validation of new biomarker for human cancers
    FRANCOIS CLARET; Fiscal Year: 2006
    ..p27, a CKI, regulates the G1/S phase transition of the cell cycle and plays a critical role in controlling the cell cycle...
  62. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    Vanessa Ortiz; Fiscal Year: 2007
    ..techniques will be employed to examine the microdomain formation by hydrolyzed chains, thought to cause a phase transition to the micellar state...
  63. Socioemotional Flexibility at the Adolescent Transition
    Thomas Hollenstein; Fiscal Year: 2005
    ..current study will test the hypothesis that the variability in early adolescent interactions is evidence of a phase transition, a dynamic systems concept that refers to periods of fluctuation observed when one stable pattern breaks down ..