cyclotrons

Summary

Summary: Devices for accelerating charged particles in a spiral path by a constant-frequency alternating electric field. This electric field is synchronized with the movement of the particles in a constant magnetic field.

Top Publications

  1. doi Measurement of thermal neutron fluence distribution with use of 23Na radioactivation around a medical compact cyclotron
    Toshioh Fujibuchi
    Department of Radiological Sciences, School of Health Sciences, Ibaraki Prefectural University, Inashiki Gun, Ibaraki, Japan
    Radiol Phys Technol 2:159-65. 2009
  2. doi Nationwide survey on the operational status of medical compact cyclotrons in Japan
    Toshioh Fujibuchi
    Department of Radiological Sciences, School of Health Sciences, Ibaraki Prefectural University, Inashiki Gun, Ibaraki, Japan
    Radiol Phys Technol 2:126-32. 2009
  3. ncbi Neutron measurements in the vicinity of a self-shielded PET cyclotron
    N E Hertel
    Neely Nuclear Research Center, G W Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332 0405, USA
    Radiat Prot Dosimetry 108:255-61. 2004
  4. ncbi Dynamic range and mass accuracy of wide-scan direct infusion nanoelectrospray fourier transform ion cyclotron resonance mass spectrometry-based metabolomics increased by the spectral stitching method
    Andrew D Southam
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
    Anal Chem 79:4595-602. 2007
  5. doi Application of Fourier-transform ion cyclotron resonance mass spectrometry to metabolic profiling and metabolite identification
    Daisaku Ohta
    Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Sakai 599 8531, Japan
    Curr Opin Biotechnol 21:35-44. 2010
  6. ncbi Mass spectrometry in demonstrating the site-specific nitration of hen egg white lysozyme by an improved electrochemical method
    Dominic Matters
    Centre for Molecular and Biomedical Sciences, Faculty of Health and Life Sciences, Coventry University, Coventry CV1 5FB, UK
    Anal Biochem 356:171-81. 2006
  7. ncbi The role of electron capture dissociation in biomolecular analysis
    Helen J Cooper
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom
    Mass Spectrom Rev 24:201-22. 2005
  8. ncbi Within the next decade conventional cyclotrons for proton radiotherapy will become obsolete and replaced by far less expensive machines using compact laser systems for the acceleration of the protons
    Chang Ming Charlie Ma
    Fox Chase Cancer Center Philadelphia, Pennsylvania 19111, USA
    Med Phys 33:571-3. 2006
  9. ncbi Positron-emitting isotopes produced on biomedical cyclotrons
    Paul McQuade
    The Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Curr Med Chem 12:807-18. 2005
  10. ncbi Reproducibility of tryptic digestion investigated by quantitative fourier transform ion cyclotron resonance mass spectrometry
    Charlotte Hagman
    Division of Ion Physics, The Angstrom Laboratory, Uppsala University, Box 534, SE 75121 Uppsala, Sweden
    J Proteome Res 4:394-9. 2005

Detail Information

Publications173 found, 100 shown here

  1. doi Measurement of thermal neutron fluence distribution with use of 23Na radioactivation around a medical compact cyclotron
    Toshioh Fujibuchi
    Department of Radiological Sciences, School of Health Sciences, Ibaraki Prefectural University, Inashiki Gun, Ibaraki, Japan
    Radiol Phys Technol 2:159-65. 2009
    ....
  2. doi Nationwide survey on the operational status of medical compact cyclotrons in Japan
    Toshioh Fujibuchi
    Department of Radiological Sciences, School of Health Sciences, Ibaraki Prefectural University, Inashiki Gun, Ibaraki, Japan
    Radiol Phys Technol 2:126-32. 2009
    ..radioactivity of the cyclotron itself and structures is an important issue in decommissioning of medical compact cyclotrons. To obtain basic data on the actual operational conditions of cyclotrons, we performed nationwide survey...
  3. ncbi Neutron measurements in the vicinity of a self-shielded PET cyclotron
    N E Hertel
    Neely Nuclear Research Center, G W Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332 0405, USA
    Radiat Prot Dosimetry 108:255-61. 2004
    ..The neutron measurements reported were made during the production of 18F via the 18O(p,n)18F reaction (Q = -2.4 MeV). Neutron spectra were obtained with the BUMS unfolding code and converted to dose equivalent rates...
  4. ncbi Dynamic range and mass accuracy of wide-scan direct infusion nanoelectrospray fourier transform ion cyclotron resonance mass spectrometry-based metabolomics increased by the spectral stitching method
    Andrew D Southam
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
    Anal Chem 79:4595-602. 2007
    ..18 ppm and detected over 3000 peaks in liver extract. This novel approach increases metabolome coverage, has very high mass accuracy, and at 5.5 min/sample is conducive for high-throughput metabolomics...
  5. doi Application of Fourier-transform ion cyclotron resonance mass spectrometry to metabolic profiling and metabolite identification
    Daisaku Ohta
    Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Sakai 599 8531, Japan
    Curr Opin Biotechnol 21:35-44. 2010
    ..Here, we discuss both the advantages and difficulties encountered in the FT-ICR/MS metabolomics studies...
  6. ncbi Mass spectrometry in demonstrating the site-specific nitration of hen egg white lysozyme by an improved electrochemical method
    Dominic Matters
    Centre for Molecular and Biomedical Sciences, Faculty of Health and Life Sciences, Coventry University, Coventry CV1 5FB, UK
    Anal Biochem 356:171-81. 2006
    ..Matrix-assisted laser desorption/ionization time-of-flight and electrospray ionization time-of-flight analysis of the tryptic peptides of mononitrated lysozyme identified the site of nitration as Tyr23...
  7. ncbi The role of electron capture dissociation in biomolecular analysis
    Helen J Cooper
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom
    Mass Spectrom Rev 24:201-22. 2005
    ..The application of ECD to the analysis of polymers, peptide nucleic acids, and oligonucleotides is also discussed...
  8. ncbi Within the next decade conventional cyclotrons for proton radiotherapy will become obsolete and replaced by far less expensive machines using compact laser systems for the acceleration of the protons
    Chang Ming Charlie Ma
    Fox Chase Cancer Center Philadelphia, Pennsylvania 19111, USA
    Med Phys 33:571-3. 2006
  9. ncbi Positron-emitting isotopes produced on biomedical cyclotrons
    Paul McQuade
    The Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Curr Med Chem 12:807-18. 2005
    ....
  10. ncbi Reproducibility of tryptic digestion investigated by quantitative fourier transform ion cyclotron resonance mass spectrometry
    Charlotte Hagman
    Division of Ion Physics, The Angstrom Laboratory, Uppsala University, Box 534, SE 75121 Uppsala, Sweden
    J Proteome Res 4:394-9. 2005
    ..These experimental observations provide a range for the up- and down-regulations that are possible to study with electrospray ionization LC FT-ICR mass spectrometry...
  11. ncbi Improving protein identification using complementary fragmentation techniques in fourier transform mass spectrometry
    Michael L Nielsen
    Laboratory for Biological and Medical Mass Spectrometry, Uppsala University, S 75123 Uppsala, Sweden
    Mol Cell Proteomics 4:835-45. 2005
    ..A specially developed test with scrambled MS/MS data revealed that the amount of false-positive identifications was dramatically reduced by the combined use of CAD and ECD...
  12. ncbi Tandem mass spectrometry for peptide and protein sequence analysis
    Joshua J Coon
    University of Virginia, Charlottesville, VA, USA
    Biotechniques 38:519, 521, 523. 2005
  13. ncbi Fourier transform ion cyclotron resonance mass spectrometry for the analysis of small ubiquitin-like modifier (SUMO) modification: identification of lysines in RanBP2 and SUMO targeted for modification during the E3 autoSUMOylation reaction
    Helen J Cooper
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Anal Chem 77:6310-9. 2005
    ....
  14. ncbi Examples of Fourier transform ion cyclotron resonance mass spectrometry developments: from ion physics to remote access biochemical mass spectrometry
    A Römpp
    FOM Institute for Atomic and Molecular Physics, Kruislaan 407, 1098 SJ Amsterdam, The Netherlands
    Eur J Mass Spectrom (Chichester, Eng) 11:443-56. 2005
    ..This concept of remote experimentation opens new possibilities for scientific collaborations between expert scientists at different locations and allows the efficient use of this expensive instrumentation...
  15. ncbi Ion-molecule reactions for the characterization of polyols and polyol mixtures by ESI/FT-ICR mass spectrometry
    Michael A Watkins
    Department of Chemistry, Purdue University, West Lafayette, Indiana 47907 2084, and Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    Anal Chem 77:1385-92. 2005
    ..The utility of this method for the analysis of polyols as single-component solutions, as mixtures, or in HPLC effluent (LC-MS analysis) is demonstrated...
  16. ncbi Determination of aberrant O-glycosylation in the IgA1 hinge region by electron capture dissociation fourier transform-ion cyclotron resonance mass spectrometry
    Matthew B Renfrow
    National High Magnetic Field Laboratory, Florida State University, Tallahassee, Florida 32310 4005, USA
    J Biol Chem 280:19136-45. 2005
    ....
  17. ncbi Principles of Fourier transform ion cyclotron resonance mass spectrometry and its application in structural biology
    Mark P Barrow
    Institute of Mass Spectrometry and Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK
    Analyst 130:18-28. 2005
    ..In this article, the basic principles are highlighted, some of the techniques employed are described and examples of applications are provided, with particular respect being paid to the field of characterization of biomolecules...
  18. ncbi Improvement of electron capture efficiency by resonant excitation
    Michael Mormann
    Institute for Medical Physics and Biophysics, Biomedical Analysis Department, University of Munster, Robert Koch Str 31, D 48149 Munster, Germany
    Rapid Commun Mass Spectrom 17:2208-14. 2003
    ..In addition to amino acid sequence information, the attachment site of the labile glycan moiety is determined, and also radical-site-induced fragmentations of the glycosidic bonds are observed...
  19. ncbi Shifts in peptide and protein charge state distributions with varying spray tip orifice diameter in nanoelectrospray Fourier transform ion cyclotron resonance mass spectrometry
    Yan Li
    Department of Chemistry, University of New Orleans, 2000 Lakeshore Drive, New Orleans, Louisiana 70148, USA
    Anal Chem 75:5739-46. 2003
    ....
  20. ncbi An automated high performance capillary liquid chromatography-Fourier transform ion cyclotron resonance mass spectrometer for high-throughput proteomics
    Mikhail E Belov
    Biological Sciences Division and Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington 99352, USA
    J Am Soc Mass Spectrom 15:212-32. 2004
    ....
  21. ncbi Protein kinase A phosphorylation characterized by tandem Fourier transform ion cyclotron resonance mass spectrometry
    Michael J Chalmers
    National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL 32310 4005, USA
    Proteomics 4:970-81. 2004
    ..The utility of activated ion ECD for the characterization of tryptic phosphopeptides was then demonstrated...
  22. ncbi The formation of complexes by tetraethylresorcarene with planar guest ions studied by electrospray ionisation Fourier transform ion cyclotron resonance mass spectrometry
    Marko Mäkinen
    Department of Chemistry, University of Joensuu, P O Box 111, 80101 Joensuu, Finland
    Rapid Commun Mass Spectrom 18:673-7. 2004
    ..Collision-induced dissociation experiments revealed the fragmentation patterns of the resorcarene skeleton and the differences in fragmentation induced by the guest ions...
  23. ncbi Quantitative analysis of tryptic protein mixtures using electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry
    Charlotte Hagman
    Department of Engineering Sciences, Division of Ion Physics, Uppsala University
    J Proteome Res 3:587-94. 2004
    ..This method can be used for observing protein dynamics in a specific cell type, tissue, or in body fluids...
  24. ncbi Production and properties of nanoelectrospray emitters used in Fourier transform ion cyclotron resonance mass spectrometry: implications for determination of association constants for noncovalent complexes
    Cleidiane G Zampronio
    Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK
    Anal Chem 76:5172-9. 2004
    ..It was found that 2-microm tip diameter resulted in more reproducible spectra than the larger tip diameters tested (6-20 microm)...
  25. ncbi Tailored noise waveform/collision-induced dissociation of ions stored in a linear ion trap combined with liquid chromatography/Fourier transform ion cyclotron resonance mass spectrometry
    Andrey N Vilkov
    Biological Sciences Division and Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, P O Box 999, MS K8 98, Richland, WA 99352, USA
    Rapid Commun Mass Spectrom 18:2682-90. 2004
    ..The experimental results are compared with data obtained using conventional quadrupole ion trap MS/MS and SORI-CID MS/MS in an ICR cell...
  26. ncbi Epitope extraction technique using a proteolytic magnetic reactor combined with Fourier-transform ion cyclotron resonance mass spectrometry as a tool for the screening of potential vaccine lead peptides
    Z Bilkova
    Laboratory of Physical Chemistry, Institute Curie UMR CNRS IC 168, Paris Cedex 05, France
    Eur J Mass Spectrom (Chichester, Eng) 11:489-95. 2005
    ..In this way, the epitope extraction technique combined with mass spectrometric analysis is shown to be an excellent base for molecular screening of potential vaccine lead proteins...
  27. ncbi Electron capture dissociation of O-glycosylated peptides: radical site-induced fragmentation of glycosidic bonds
    Michael Mormann
    Institute for Medical Physics and Biophysics, Biomedical Analysis Department, University of Munster, Robert Koch Str 31, D 48149 Munster, Germany
    Eur J Mass Spectrom (Chichester, Eng) 11:497-511. 2005
    ..The different sugar core types exhibit different fragmentation patterns driven by the stability of the resulting fragments allowing the discrimination of isomeric glycans...
  28. ncbi Disulfide bond cleavages observed in SORI-CID of three nonapeptides complexed with divalent transition-metal cations
    Romulus Mihalca
    FOM Institute for Atomic and Molecular Physics AMOLF, Kruislaan 407, 1098 SJ Amsterdam, The Netherlands
    J Mass Spectrom 42:450-8. 2007
    ..This approach offers an efficient way to cleave disulfide-bridged structures using low energy MS/MS, which leads to increased sequence coverage and more confidence in peptide or protein assignments...
  29. ncbi Study on the quality control of cell therapy products. Determination of N-glycolylneuraminic acid incorporated into human cells by nano-flow liquid chromatography/Fourier transformation ion cyclotron mass spectrometry
    Noritaka Hashii
    Division of Biological Chemistry and Biologicals, National Institute of Health Sciences, 1 18 1 Kamiyouga, Setagaya Ku, Tokyo 158 8501, Japan
    J Chromatogr A 1160:263-9. 2007
    ..Our method needs only 2.5x10(3) cells for one injection and would be applicable to the determination of NeuGc in cell therapy products...
  30. pmc Steady-state asymmetric nanospray dual ion source for accurate mass determination within a chromatographic separation
    Nicolas L Young
    BioSecurity and NanoSciences Laboratory, Lawrence Livermore National Laboratory, Livermore, California 94551, USA
    Anal Chem 79:5711-8. 2007
    ..Because of the low cost of implementation, the new source could potentially be applied to other forms of mass spectrometry, such as electrospray ionization-time-of-flight (ESI-TOF), which can benefit from internal mass calibration...
  31. ncbi Application of FT-ICR-MS for the study of proton-transfer reactions involving biomolecules
    E D Raczyńska
    Department of Chemistry, Warsaw University of Agriculture SGGW, 02 726 Warsaw, Poland
    Anal Bioanal Chem 389:1365-80. 2007
    ..They also indicate the form (unionized, zwitterionic, protonated, or deprotonated) which the biomolecule may take in a nonpolar environment...
  32. ncbi Comparison of collision-induced dissociation and electron-induced dissociation of singly protonated aromatic amino acids, cystine and related simple peptides using a hybrid linear ion trap-FT-ICR mass spectrometer
    Hadi Lioe
    School of Chemistry, University of Melbourne, Melbourne, Victoria 3010, Australia
    Anal Bioanal Chem 389:1429-37. 2007
    ..EID may find applications in analyzing singly charged molecular ions formed by matrix-assisted laser desorption ionization...
  33. ncbi Realistic modeling of ion cloud motion in a Fourier transform ion cyclotron resonance cell by use of a particle-in-cell approach
    Eugene N Nikolaev
    The Institute for Energy Problems of Chemical Physics, Russian Academy of Sciences, Leninskij pr 38, k 2, Moscow, Russia 119334
    Rapid Commun Mass Spectrom 21:3527-46. 2007
    ..The ion cloud evolution time-scale is inversely proportional to magnetic field. The number of ions needed for peak coalescence depends quadratically on the magnetic field...
  34. ncbi De novo sequencing of a 21-kDa cytochrome c4 from Thiocapsa roseopersicina by nanoelectrospray ionization ion-trap and Fourier-transform ion-cyclotron resonance mass spectrometry
    Rui Miguel Mamede Branca
    Institute of Biophysics, Biological Research Centre, Hungarian Academy of Sciences, Szeged, Hungary
    J Mass Spectrom 42:1569-82. 2007
    ..The predominantly automated nature of data acquisition and handling allowed for a relatively straightforward and fast procedure, which could compete with the mainstream alternative of nucleotide sequence determination...
  35. doi The effects of chromium(III) coordination on the dissociation of acidic peptides
    Dan Pu
    Department of Chemistry, The University of Alabama, Tuscaloosa, AL 35487 0336, USA
    J Mass Spectrom 43:773-81. 2008
    ..This is consistent with deprotonated carboxylic acid groups being involved in chromium(III) coordination and with chromium existing in the 3 + state in the gas-phase ions...
  36. ncbi Fragmentation of singly protonated peptides via a combination of infrared and collisional activation
    Eric D Dodds
    Department of Chemistry, University of California Davis, One Shields Avenue, Davis, California 95616, USA
    Anal Chem 78:8506-11. 2006
    ....
  37. pmc Evaluation of a novel approach for peptide sequencing: laser-induced acoustic desorption combined with P(OCH(3))(2)(+) chemical ionization and collision-activated dissociation in a Fourier transform ion cyclotron resonance mass spectrometer
    Jayalakshmi Somuramasami
    Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA
    J Am Soc Mass Spectrom 18:525-40. 2007
    ..The mechanisms of the reactions of peptides with P(OCH(3))(2)(+) and the dissociation of the (peptide + P - 2H)(+) ions were examined by using model peptides and molecular orbital calculations...
  38. ncbi Structural characterisation of tyrosine-nitrated peptides by ultraviolet and infrared matrix-assisted laser desorption/ionisation Fourier transform ion cyclotron resonance mass spectrometry
    Brînduşa Alina Petre
    Laboratory of Analytical Chemistry and Biopolymer Structure Analysis, Department of Chemistry, University of Konstanz, 78457 Konstanz, Germany
    Eur J Mass Spectrom (Chichester, Eng) 11:513-8. 2005
    ..In contrast, infrared-MALDI-FT-ICR-MS did not produce fragmentation of molecular ions of Tyr-nitrated peptides...
  39. ncbi Characterisation of cytochrome c unfolding by nano-electrospray ionization time-of-fight and Fourier transform ion cyclotron resonance mass spectrometry
    Nikolay Youhnovski
    Department of Chemistry, Laboratory of Analytical Chemistry, University of Konstanz, 78457 Konstanz, Germany
    Eur J Mass Spectrom (Chichester, Eng) 11:519-24. 2005
    ..Nevertheless, the ToF instrument appears to discriminate better between unfolded and partially unfolded forms...
  40. ncbi Mapping protein interfaces by chemical cross-linking and Fourier transform ion cyclotron resonance mass spectrometry: application to a calmodulin / adenylyl cyclase 8 peptide complex
    Andreas Schmidt
    Biotechnological Biomedical Center, Faculty of Chemistry and Mineralogy, University of Leipzig, D 04103 Leipzig, Germany
    Eur J Mass Spectrom (Chichester, Eng) 11:525-34. 2005
    ..The identified intermolecular cross-linking products will give further insight into calmodulin/adenylyl cyclase 8 interaction...
  41. ncbi Investigation of gas phase ion structure for proline-containing b(2) ion
    Lori L Smith
    Department of Chemistry, University of Arizona, Tucson, Arizona 85721, USA
    J Am Soc Mass Spectrom 17:20-8. 2006
    ..Finally, high-resolution, accurate mass measurements determined that the V(NmA) (b(2)-71) ion results from losing a portion of valine from oxazolone V(NmA) b(2) ion, rather than cross-ring cleavage of the alternate diketopiperazine...
  42. ncbi Tandem mass spectrometry in quadrupole ion trap and ion cyclotron resonance mass spectrometers
    Anne H Payne
    Department of Chemistry, University of North Carolina, Chapel Hill, NC, USA
    Methods Enzymol 402:109-48. 2005
    ..This chapter covers the basic principles of operation of these instruments, including the trapping/manipulation/detection of ions and various approaches used to activate ions to perform tandem mass spectrometry experiments...
  43. ncbi Protonation thermochemistry of aminoacetonitrile
    Guy Bouchoux
    Laboratoire des Mecanismes Reactionnels, UMR CNRS 7651, Departement de Chimie, Ecole Polytechnique, 91128 Palaiseau Cedex, France
    Rapid Commun Mass Spectrom 20:1187-91. 2006
    ..6 J x mol(-1) x K(-1). Combining this value with experimental GB(1) leads to an 'experimental' proton affinity of 819.2 kJ x mol(-1), in close agreement with the G2 expectation...
  44. ncbi Sub parts-per-million mass measurement accuracy of intact proteins and product ions achieved using a dual electrospray ionization quadrupole fourier transform ion cyclotron resonance mass spectrometer
    D Keith Williams
    W M Keck FT ICR Mass Spectrometry Laboratory, Department of Chemistry, North Carolina State University Raleigh, North Carolina 27695, USA
    J Am Soc Mass Spectrom 18:1-7. 2007
    ..0 ppm to 1.1 ppm, with an average of -0.9 ppm. This method requires limited modification to ESI-FT-ICR mass spectrometers and is applicable for both positive and negative ionization modes...
  45. ncbi Measurement of deamidation of intact proteins by isotopic envelope and mass defect with ion cyclotron resonance Fourier transform mass spectrometry
    Noah E Robinson
    Oregon Institute of Science and Medicine, 2251 Dick George Road, Cave Junction, OR 97523, USA
    Rapid Commun Mass Spectrom 20:3535-41. 2006
    ..The envelope deconvolution method is further illustrated by detection of deamidation in intact gammaS crystallin, a 20 904 Da protein, and discovery of the principal gammaS deamidation site...
  46. pmc CrossSearch, a user-friendly search engine for detecting chemically cross-linked peptides in conjugated proteins
    Owen W Nadeau
    Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Mol Cell Proteomics 7:739-49. 2008
    ..The results offer proof of concept for the CrossSearch strategy for analyzing conjugates and are the first to reveal a tertiary structural element of either homologous alpha or beta regulatory subunit of phosphorylase kinase...
  47. ncbi FTMS structure elucidation of natural products: application to muraymycin antibiotics using ESI multi-CHEF SORI-CID FTMS(n), the top-down/bottom-up approach, and HPLC ESI capillary-skimmer CID FTMS
    Leonard A McDonald
    Chemical Sciences, Wyeth Research, Pearl River, New York 10965, USA
    Anal Chem 75:2730-9. 2003
    ..Sequential neutral losses of an aminosugar, a valine, a uridine, and an ester fatty acid from the muraymycin parent ions provided diagnostic fragments for characterization...
  48. ncbi Characterization of amino acid side chain losses in electron capture dissociation
    Helen J Cooper
    Ion Cyclotron Resonance Program, National High Magnetic Field Laboratory, Florida State University, Tallahassee 32310, USA
    J Am Soc Mass Spectrom 13:241-9. 2002
    ..Losses from arginine, histidine, and asparigine/glutamine can be used to ascertain their presence, as in the analysis of unknown peptides, particularly those with non-linear structures...
  49. ncbi The unanticipated loss of SO2 from sulfonamides in collision-induced dissociation
    Zhen Wang
    Department of Drug Metabolism, Merck Research Laboratories, Rahway, NJ 07065 0900, USA
    Rapid Commun Mass Spectrom 17:81-6. 2003
    ..The neutral loss involving the cleavage of two bonds was unanticipated and suggested a complex rearrangement process. A mechanism for the loss of SO(2) has been proposed...
  50. ncbi Proton bound homodimers and heterodimers of amides and amines in the gas phase. Equilibrium studies by Fourier transform ion cyclotron resonance spectrometry
    Matthias Witt
    Fakultat fur Chemie, Universitat Bielefeld, Germany
    J Am Soc Mass Spectrom 13:1273-81. 2002
    ..The available data have been used to calculate the molecular pair gas phase basicity of DMF and the 13 bases used and to estimate the dissociation energies of the bonds of the proton bridge in various proton bound heterodimers...
  51. pmc The interaction between the chaperone SecB and its ligands: evidence for multiple subsites for binding
    L L Randall
    Department of Biochemistry and Biophysics, Washington State University, Pullman 99164 4660, USA
    Protein Sci 7:2384-90. 1998
    ..Here we have used titration calorimetry, analytical ultracentrifugation, and electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry to obtain evidence that such distinguishable subsites exist...
  52. ncbi High sensitivity Fourier transform ion cyclotron resonance mass spectrometry for biological analysis with nano-LC and microelectrospray ionization
    T L Quenzer
    National High Magnetic Field Laboratory, Florida State University, 1800 East Paul Dirac Drive, Tallahassee, Florida 32310, USA
    Anal Chem 73:1721-5. 2001
    ..Arg8-vasotocin isolated from the pineal gland of rainbow trout is detected, demonstrating the ability of FT-ICR to detect and identify a true endogenous biological analyte...
  53. ncbi In-source H/D exchange and ion-molecule reactions using matrix assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry with pulsed collision and reaction gases
    Matthias Witt
    Bruker Daltonik GmbH, Bremen, Germany
    J Am Soc Mass Spectrom 13:308-17. 2002
    ..Amino acid sequence, structural flexibility and folding state of the peptides can be seen to play a part in the reactivity of such ions...
  54. ncbi Gas-phase cleavage of PTC-derivatized electrosprayed tryptic peptides in an FT-ICR trapped-ion cell: mass-based protein identification without liquid chromatographic separation
    G van der Rest
    Center for Interdisciplinary Magnetic Resonance, National High Magnetic Field Laboratory, Florida State University, Tallahassee 32310, USA
    J Am Soc Mass Spectrom 12:288-95. 2001
    ..The method is robust-it succeeds even with partial tryptic digestion, partial Edman derivatization, and partial MS/MS IRMPD cleavage. Improved efficiency and automation should be straightforward...
  55. ncbi Increased proteome coverage for quantitative peptide abundance measurements based upon high performance separations and DREAMS FTICR mass spectrometry
    Ljiljana Pasa-Tolic
    Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington 99352, USA
    J Am Soc Mass Spectrom 13:954-63. 2002
    ..We show that implementation of the DREAMS approach allows assignment of approximately 80% more peptide pairs, thus providing quantitative information for approximately 18,000 peptide pairs in a single analysis...
  56. ncbi Electron capture dissociation of polypeptides using a 3 Tesla Fourier transform ion cyclotron resonance mass spectrometer
    Nicolas C Polfer
    Department of Chemistry, The University of Edinburgh, King s Buildings, West Main Road, EH9 3JJ, Scotland, UK
    Rapid Commun Mass Spectrom 16:936-43. 2002
    ....
  57. ncbi Liquid chromatography and electron-capture dissociation in Fourier transform ion cyclotron resonance mass spectrometry
    Magnus Palmblad
    Division of Ion Physics, The Angstrom Laboratory, Uppsala University, Box 534, SE 751 21, Sweden
    Rapid Commun Mass Spectrom 16:988-92. 2002
    ..The results suggest that LC/ECD-FTICRMS can be employed in the characterization of peptides in enzymatic digests of proteins or protein mixtures and identify and localize posttranslational modifications...
  58. ncbi Multiple ion isolation applications in FT-ICR MS: exact-mass MSn internal calibration and purification/interrogation of protein-drug complexes
    Gary Kruppa
    Bruker Daltonics Inc, Billerica, Massachusetts 01821, USA
    Anal Chem 74:3877-86. 2002
    ....
  59. ncbi Optimization of experimental parameters for electron capture dissociation of peptides in a Fourier transform mass spectrometer
    T W Dominic Chan
    Department of Chemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
    J Am Soc Mass Spectrom 13:1396-406. 2002
    ..e., neutralization of the fragment ions, might be a significant event for limiting the intensity of the fragment ions...
  60. ncbi Broadband detection electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry to reveal enzymatically and chemically induced deamidation reactions within peptides
    D G Schmid
    , , Germany
    Anal Chem 73:6008-13. 2001
    ..Using broadband detection, we were able to resolve ions with a difference of m/z 0.0064 to detect partially deamidated peptides formed either enzymatically or under acidic and basic conditions...
  61. ncbi Improved low-energy electron injection systems for high rate electron capture dissociation in Fourier transform ion cyclotron resonance mass spectrometry
    Y O Tsybin
    Ion Physics Division, , Uppsala University, Box 534, SE-751 21 Uppsala, Sweden
    Rapid Commun Mass Spectrom 15:1849-54. 2001
    ..The ECD rate improvement is not only due to the larger total electron current, but the larger emitting area as well...
  62. ncbi Manipulating internal energy of protonated biomolecules in electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry
    Xinghua Guo
    FOM Institute for Atomic and Molecular Physics, Kruislaan 407, 1098 SJ Amsterdam, The Netherlands
    J Mass Spectrom 38:597-606. 2003
    ....
  63. ncbi Gas-phase reactions of charged phenyl radicals with neutral biomolecules evaporated by laser-induced acoustic desorption
    Christopher J Petzold
    Department of Chemistry, Purdue University, West Lafayette, Indiana 47907 1393, USA
    J Am Soc Mass Spectrom 13:192-4. 2002
    ..Further, a previously unstudied reaction of the nucleotide of thymine (T1) with charged phenyl radical was found to yield analogous products as the reaction with thymidine...
  64. ncbi Scaling MS plateaus with high-resolution FT-ICRMS
    Alan G Marshall
    National High Magnetic Field Laboratory, Florida State University, Tallahassee 32310, USA
    Anal Chem 74:252A-259A. 2002
  65. ncbi Optimal pressure conditions for unbiased external ion accumulation in a two-dimensional radio-frequency quadrupole for Fourier transform ion cyclotron resonance mass spectrometry
    M E Belov
    Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, P.O. Box 999, Richland, WA 99352, USA
    Rapid Commun Mass Spectrom 15:1988-96. 2001
    ..External ion accumulation performed at the optimal pressure resulted in an increase in both the spectrum acquisition rates and dynamic range...
  66. ncbi Comparison of electron capture dissociation and collisionally activated dissociation of polycations of peptide nucleic acids
    J V Olsen
    Department of Chemistry, University of Southern Denmark, DK-5230 Odense M, Denmark
    Rapid Commun Mass Spectrom 15:969-74. 2001
    ..This was rationalized through the lower degree of charge solvation on the backbone compared to polypeptides. Combination of both CAD and ECD data is advantageous, as these techniques produce cleavages at different sites...
  67. ncbi Nano-high-performance liquid chromatography in combination with nano-electrospray ionization Fourier transform ion-cyclotron resonance mass spectrometry for proteome analysis
    Christian Ihling
    Biotechnological Biomedical Center, Institute of Analytical Chemistry, University of Leipzig, 04103 Leipzig, Germany
    Rapid Commun Mass Spectrom 17:1240-6. 2003
    ..Parallel identification of proteins from complex mixtures down to low-femtomole levels makes nano-HPLC/nano-ESI-FTICRMS an attractive approach for proteome analysis...
  68. ncbi Silica-based monoliths for rapid peptide screening by capillary liquid chromatography hyphenated with electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry
    Felix C Leinweber
    Otto von Guericke Universitat Magdeburg, Institut fur Verfahrenstechnik, Universitatsplatz 2, D 39106 Magdeburg, Germany
    Rapid Commun Mass Spectrom 17:1180-8. 2003
    ..Libraries with more than 1000 different peptides could be screened in less than 20 min...
  69. ncbi Radiobiology with heavy charged particles: a historical review
    L D Skarsgard
    Department of Medical Biophysics, B C Cancer Research Centre, Vancouver, Canada
    Phys Med 14:1-19. 1998
    ..There followed a series of cyclotrons, synchrotrons and linear accelerators, culminating in the BEVALAC, which provided the first source of very heavy ..
  70. doi Fluorine-18 radiopharmaceuticals beyond [18F]FDG for use in oncology and neurosciences
    H H Coenen
    Institut für Neurowissenschaften und Medizin, INM 5 Institut für Nuklearchemie, Forschungszentrum Julich GmbH, D 52425 Julich, Germany
    Nucl Med Biol 37:727-40. 2010
    ..PET) is a rapidly expanding clinical modality worldwide thanks to the availability of compact medical cyclotrons and automated chemistry for the production of radiopharmaceuticals...
  71. ncbi Radiotherapy systems using proton and carbon beams
    Y Jongen
    Ingénieur civil en electronique Administrateur Délégué IBA
    Bull Mem Acad R Med Belg 163:471-8; discussion 479-80. 2008
    ..In addition to the now classical proton therapy equipments, using synchrotrons or cyclotrons as accelerators, new solutions have been proposed, claiming to be more compact and less expensive...
  72. ncbi Quantification of regional myocardial perfusion with generator-produced 62Cu-PTSM and positron emission tomography
    P Herrero
    Cardiovascular Division, Washington University School of Medicine, St Louis, MO 63110
    Circulation 87:173-83. 1993
    ..Centers that do not have cyclotrons rely on generator-produced radioisotopes for assessment of regional myocardial perfusion with positron emission ..
  73. ncbi Chemical processing for production of no-carrier-added selenium-73 from germanium and arsenic targets and synthesis of L-2-amino-4-([73Se]methylseleno) butyric acid (L-[73Se]selenomethionine)
    A Plenevaux
    Cyclotron Research Center, , Belgium
    Int J Rad Appl Instrum A 41:829-38. 1990
    ..With 26 MeV alpha particles, available with compact cyclotrons, the first reaction required an enriched 70Ge target of sodium metagermanate to give a production yield of 1 mCi/..
  74. ncbi Can gallium-68 compounds partly replace (18)F-FDG in PET molecular imaging?
    Margarita Pagou
    Hell J Nucl Med 12:102-5. 2009
    ..makes it attractive to use in busy nuclear medicine departments, particularly those with limited access to cyclotrons. The recent clinical experience with (68)Ga-peptides includes imaging neuroendocrine tumours particularly ..
  75. ncbi Fast neutron radiation therapy. Results of phase III randomized trials in head and neck, lung, and prostate cancers
    W J Koh
    Department of Radiation Oncology, University of Washington Medical Center, Seattle 98195
    Acta Oncol 33:293-8. 1994
    ..studies in which fast neutrons were delivered using modern, hospital-based, high-energy, isocentric-capable cyclotrons. In locally advanced squamous cell head and neck cancers, neutrons showed no convincing advantage over photons...
  76. ncbi [Use of radionuclides in therapy]
    J Vucina
    Institut za nuklearne nauke Vinca, Laboratorija za radioizotope, 11001 Beograd
    Med Pregl 54:245-50. 2001
    ..However, considerable efforts are required in selecting an optimal radionuclide for a specific application and then, in the development of methods for its routine production...
  77. ncbi The state of positron emitting radionuclide production in 1997
    T J McCarthy
    Mallinckrodt Institute of Radiology, Washington University Medical School, St Louis, MO 63110, USA
    Semin Nucl Med 28:235-46. 1998
    ..predictions to the current state of the art, we have broken this into four key areas; commercially available cyclotrons, costs of operating cyclotron facilities, the emergence of compact accelerators, and the cyclotron production of ..
  78. ncbi [Nationwide survey on radioactive waste management related to positron emission tomography in Japan]
    Hiroaki Nagaoka
    Iwate Medical University Hospital
    Nihon Hoshasen Gijutsu Gakkai Zasshi 65:1644-9. 2009
    ..It was expected that this new regulation would mediate the installation of clearance systems in Japan. In order to assess the current situation of radiation safety management in PET institutions, we conducted a nationwide survey...
  79. ncbi Neutron carcinogenesis: past, present, and future
    C K Hill
    Department of Radiation Oncology, USC School of Medicine, Los Angeles 90089, USA
    J Radiat Res 40:117-27. 1999
    ..Early use of neutrons from radioactive sources and from cyclotrons led to a need to define risk for such exposures...
  80. ncbi Special radiation protection aspects of medical accelerators
    M Silari
    CERN, Geneva, Switzerland
    Radiat Prot Dosimetry 96:381-92. 2001
    ..of machines are considered: (1) medical electron linacs for 'conventional' radiation therapy, (2) low energy cyclotrons for production of radionuclides mainly for medical diagnostics and (3) medium energy cyclotrons and synchrotrons ..
  81. ncbi Advanced treatment planning methods for efficient radiation therapy with laser accelerated proton and ion beams
    Stefan Schell
    Department of Radiation Oncology, Technische Universitat Munchen, Klinikum rechts der Isar, Ismaninger Str 22, 81675 Munchen, Germany
    Med Phys 37:5330-40. 2010
    Laser plasma acceleration can potentially replace large and expensive cyclotrons or synchrotrons for radiotherapy with protons and ions...
  82. ncbi The AAPM/RSNA physics tutorial for residents. Radiopharmaceuticals
    J A Ponto
    Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City 52242, USA
    Radiographics 18:1395-404. 1998
    ..are produced in a number of ways: as by-products of fission, by means of neutron activation, by cyclotrons, and by generators. These methods produce isotopes with both desirable and undesirable properties...
  83. ncbi Unconventional nuclides for radiopharmaceuticals
    Jason P Holland
    Radiochemistry Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Mol Imaging 9:1-20. 2010
    ..With the increased availability of small, low-energy cyclotrons and improvements in both cyclotron targetry and purification chemistries, the use of "nonstandard" radionuclides ..
  84. ncbi Production of highly charged heavy ions by 18 GHz superconducting electron cyclotron resonance at Research Center for Nuclear Physics
    Tetsuhiko Yorita
    Research Center for Nuclear Physics RCNP, Osaka University, Osaka 567 0047, Japan
    Rev Sci Instrum 81:02A332. 2010
    ..Hatanaka et al., in Proceedings of the 17th International Conference on Cyclotrons and Their Applications, Tokyo, Japan, 18-22 October 2004, pp...
  85. ncbi Advanced-technology radiation therapy in the management of bone and soft tissue sarcomas
    Thomas F DeLaney
    Northeast Proton Therapy Center, Massachusetts General Hospital, Boston, MA 02114, USA
    Cancer Control 12:27-35. 2005
    ..For patients with sarcomas, radiotherapy can be used as neoadjuvant, adjuvant, or primary local therapy, depending on the site and type of sarcoma, the surgical approach, and the efficacy of chemotherapy...
  86. ncbi Accelerators for heavy-charged-particle radiation therapy
    George B Coutrakon
    Department of Radiation Medicine, Loma Linda University Medical Center, 11234 Anderson Street, Loma Linda, CA 92354, USA
    Technol Cancer Res Treat 6:49-54. 2007
    ..The accelerator types are a combination of synchrotrons, cyclotrons, and linear accelerators; some carry advanced features such as respiration gating, intensity modulation, and ..
  87. pmc Target foil rupture scenario and provision for handling different models of medical cyclotrons used in India
    V S Shaiju
    Radiological Physics and Advisory Division, Bhabha Atomic Research Centre, Mumbai 400 094, India
    J Med Phys 34:161-6. 2009
    ..Recommendations have also been made to reduce personal exposure while handling the target foil rupture condition such as the use of L-Bench near the target area and participation of experienced personnel...
  88. ncbi Positron emission tomography/computed tomography (PET/CT) in children
    Richard M Shore
    Children s Memorial Hospital, Chicago, USA
    Pediatr Ann 37:404-12. 2008
    ..other than FDG are significantly more limited in their availability and are limited to PET centers with on-site cyclotrons. However, these additional agents open the door to many additional studies, including more specific tumor-..
  89. ncbi [Synthesis of radiopharmaceuticals for PET investigations]
    Pal Mikecz
    Debreceni Egyetem, Orvos és Egészségtudományi Centrum, PET Centrum, Debrecen
    Orv Hetil 143:1240-2. 2002
    ..The first step of this process is the isotope production by small cyclotrons. The synthons made from the isotopes react with the precursor of the given radiopharmaceutical...
  90. pmc PET/CT: Current status in India
    Venkatesh Rangarajan
    BioImaging Unit, Tata Memorial Center, Parel, Mumbai, 400012, India
    Indian J Radiol Imaging 18:290-4. 2008
    ..From stand-alone PET/CT systems with on-site cyclotrons, mostly in the government sector, the modality has matured to such an extent that, today, the majority of the ..
  91. ncbi Multiple Cyclotron Method to Search for CP Violation in the Neutrino Sector
    J M Conrad
    Department of Physics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Phys Rev Lett 104:141802. 2010
    New low-cost, high-power proton cyclotrons open the opportunity for a novel precision search for CP violation in the light neutrino sector...
  92. ncbi Personal dose monitoring in hospitals: global assessment, critical applications and future needs
    P Covens
    Radiation Protection Department, Vrije Universiteit Brussel, UZ Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium
    Radiat Prot Dosimetry 124:250-9. 2007
    ..in interventional radiology (IR), in vitro biomedical research and radiopharmaceutical production around cyclotrons. Besides the fact that many of the staff members, involved in these applications, are not measurably exposed, ..
  93. pmc Production of 34m Cl and 38 Cl via the (d,α) reaction on 36 Ar and nat Ar gas at 8.4 MeV
    Jonathan W Engle
    University of Wisconsin, Department of Medical Physics, 1111 Highland Avenue, Madison, WI 53705, USA
    Appl Radiat Isot 69:75-9. 2011
    Production of (38)Cl and (34m)Cl via the (d, α) reaction on natural argon and (36)Ar reveal medical cyclotrons' ability to supply these isotopes in small quantities...
  94. ncbi Opioid imaging
    Alexander Hammers
    Department of Clinical Neuroscience, Division of Neuroscience and Mental Health, Imperial College London, Hammersmith Hospital, DuCane Rd, London W12 0NN, UK
    Neuroimaging Clin N Am 16:529-52, vii. 2006
    ..SPECT) tracers are lacking, but with the increase in the number of available PET (or PET/CT) cameras and cyclotrons thanks to the clinical successes of PET in oncology, PET may become widespread enough to overcome this ..
  95. ncbi The isochronous cyclotron: principles and recent developments
    K Strijckmans
    Institute for Nuclear Sciences, Ghent University, INW RUG, Proeftuinstraat 86, B 9000, Gent, Belgium
    Comput Med Imaging Graph 25:69-78. 2001
    ..operation and negative (vs positive) ion acceleration (and extraction) are explained, as they make dedicated PET cyclotrons a simple, reliable, and suitable tool...
  96. ncbi Production of no carrier added 80mBr for investigation of Auger electron toxicity
    R C Mease
    Chemistry Division, Argonne National Laboratory, IL 60439
    Int J Rad Appl Instrum A 42:57-61. 1991
    ..This route is therefore superior for current medical cyclotrons. Irradiation of a reusable 80Se copper selenide target also yielded multi-millicurie amounts of 80mBr, and ..
  97. ncbi [Radiosurgery: basic principles]
    D Porcheron
    Unité de Radiochirurgie Gamma Knife, Service de Neurochirurgie Fonctionnelle et Stereotaxique, Hopital d Adulte de la Timone, Marseille
    Neurochirurgie 50:265-9. 2004
    ..high energy LINAC X-rays modified in comparison to their classical use in external radiation therapy, and, more rarely, protons produced in cyclotrons. Several teams world-wide are still perfecting and refining this developing technique.
  98. ncbi Decay data and production yields of some non-standard positron emitters used in PET
    S M Qaim
    Institute of Nuclear Chemistry, Research Center Jülich GmbH, Julich, Germany
    Q J Nucl Med Mol Imaging 52:111-20. 2008
    ..are produced in good yields at low energy cyclotrons while for production of some other radionuclides (e.g. 52Fe, 73Se, 83Sr, etc...
  99. ncbi Excitation functions of 125Te(p, xn)-reactions from their respective thresholds up to 100 MeV with special reference to the production of 124I
    A Hohn
    Institut für Nuklearchemie, Forschungszentrum Julich GmbH, Germany
    Appl Radiat Isot 55:149-56. 2001
    ..The proposed production energy range is too high for small cyclotrons but large quantities of 124I can be produced with medium-sized commercial machines.
  100. doi Comparison of neutron fluxes in an 18-MeV unshielded cyclotron room and a 16.5-MeV self-shielded cyclotron room
    Toshioh Fujibuchi
    Department of Radiological Sciences, School of Health Sciences, Ibaraki Prefectural University of Health Sciences, Ami 4669 2, Ami Machi, Inashiki Gun, Ibaraki 300 0394, Japan
    Radiol Phys Technol 5:156-65. 2012
    Some medical compact cyclotrons have self-shielding to reduce neutron fluxes. Thermal neutron fluxes in an 18-MeV unshielded cyclotron room and in a 16.5-MeV self-shielded cyclotron room were evaluated...
  101. doi Effect of pulse-modulated microwaves on fullerene ion production with electron cyclotron resonance ion source
    T Asaji
    Tateyama Machine Co Ltd, 30 Shimonoban, Toyama, Toyama 930 1305, Japan
    Rev Sci Instrum 83:02A303. 2012
    ..34 times higher than that for CW mode. We have studied the responses of fullerene and argon plasmas to pulsed microwaves. After the turnoff of microwave power, fullerene plasmas lasted ∼30 times longer than argon plasmas...

Research Grants64

  1. REGENERATIVE TURBINE CYCLOTRON TARGETRY FOR F-18 PET
    BRUCE WIELAND; Fiscal Year: 2004
    ..Ninety six cyclotrons in US hospitals and distribution centers currently bombard stable enriched O-18 water targets with protons to ..
  2. THERMOSYPHON TARGETRY TO IMPROVE F-18 PET
    BRUCE WIELAND; Fiscal Year: 2006
    ..Removing more heat allows full use of the available proton beam current in the installed base of PET cyclotrons, thus at least doubling the production of O-18(p,n)F-18 for FDG (feasibility established by Phase I prototype ..
  3. Cyclotron for PET Isotope Production
    Kenneth Krohn; Fiscal Year: 2002
    ..Although it has the lowest energy of the cyclotrons we considered, it has high current output and relatively low shielding requirements and it will meet our current ..
  4. 18F-FP-DTBZ for PET Imaging of Beta Cell Mass in Diabetes
    Daniel Skovronsky; Fiscal Year: 2007
    ..means that C-DTBZ clinical studies are only feasible at a limited number of centers with on-site cyclotrons. Since the PET isotope F has a 110 min...
  5. Structural Mapping of Protein Complexes by Hydrogen/Deuterium Exchange
    Alan Marshall; Fiscal Year: 2007
    ..This project is multidisiplinary and pulls together several distinguished collaborators with focused research projects that will benefit directly from H/D exchange with high-resolution mass analysis. ..
  6. Structural Mapping of Protein Complexes by Hydrogen/Deuterium Exchange
    Alan Marshall; Fiscal Year: 2009
    ..This project is multidisiplinary and pulls together several distinguished collaborators with focused research projects that will benefit directly from H/D exchange with high-resolution mass analysis. ..
  7. MASS SPECTROMETRY STUDIES ON RADICAL REACTIONS OF DNA
    HILKKA KENTTAMAA; Fiscal Year: 2007
    ..q the best way to incorporate knowled,qe into the desi,qn and testing of novel drugs.] ..
  8. ASTATINE AND IODINE RADIOLABELED MONOCLONAL ANTIBODIES
    Michael Rod Zalutsky; Fiscal Year: 2010
    ..Furthermore, these labeling methods should be applicable to other internalizing mAbs and fragments, increasing the potential impact of this work. ..
  9. Prediction of Second Cancer Risks for Children Treated with Proton - vs. - Photon
    Wayne D Newhauser; Fiscal Year: 2010
    ..In the future, we expect that the lower-risk treatments will result in fewer second cancers and this will translate into longer, higher-quality lives for survivors of childhood cancer (presently 270,000 persons in the United States). ..
  10. MASS SPECTROMETRY STUDIES ON RADICAL REACTIONS OF DNA
    HILKKA INKERI KENTTAMAA; Fiscal Year: 2010
    ..Further, this research advances the general understanding of aging and various diseases, including cancer. ..
  11. Protein Surface Mapping: Experimentation and Computation
    Robert Hettich; Fiscal Year: 2007
    ..At present, this experimental capability is non-existent. ..
  12. MASS SPECTROMETRY STUDIES ON RADICAL REACTIONS OF DNA
    HILKKA KENTTAMAA; Fiscal Year: 2007
    ....
  13. MONTE CARLO TOOLS FOR IMRT
    Chang Ming Ma; Fiscal Year: 2001
    ..abstract_text> ..
  14. INSTRUMENTATION FOR PROTEOMICS
    Jay Fox; Fiscal Year: 2001
    ..abstract_text> ..
  15. MASS SPECTROMETRY STUDIES ON RADICAL REACTIONS OF DNA
    HILKKA KENTTAMAA; Fiscal Year: 2000
    ..Finally, different methods to trap radicals are evaluated for possible application in prevention of free radical damage caused by such conditions as Alzheimer s disease and strokes. ..
  16. Astatine 211 & Radioiodine Labeled Octreotide Conjugates
    Michael Zalutsky; Fiscal Year: 2004
    ..The proposed in vitro studies include characterization of binding, internalization and catabolism; the proposed in vivo studies include evaluation of tissue distribution, dosimetry, catabolism as well as therapeutic efficacy. ..
  17. MASS SPECTROMETRY STUDIES ON RADICAL REACTIONS OF DNA
    HILKKA KENTTAMAA; Fiscal Year: 2004
    ..This paradigm will be ultimately employed to design target-specific radical warheads that can be generated photolytically for site-specific tumor. ..
  18. Investigation of Monte Carlo Tools for IMRT
    Chang Ming Ma; Fiscal Year: 2005
    ..The results will be used as reference materials in retrospective studies as well as ongoing clinical trials. ..
  19. Quantative and Phospho Proteomics Instrumentation
    Jay Fox; Fiscal Year: 2006
    ....