Genomes and Genes
Summary: Positively-charged atomic nuclei that have been stripped of their electrons. These particles have one or more units of electric charge and a mass exceeding that of the Helium-4 nucleus (alpha particle).
Publications200 found, 100 shown here
- The radiobiological effectiveness of carbon-ion beams on growing neuronsWael S Al-Jahdari
Department of Radiation Oncology, Gunma University Graduate School of Medicine, Gunma, Japan
Int J Radiat Biol 85:700-9. 2009..However, the biological effect of carbon-ion beams arising on normal neuron remains unknown. Therefore, this study was undertaken to investigate the effect of carbon-ion beams on neurons by using both morphological and functional assays...
- High-LET radiation induces inflammation and persistent changes in markers of hippocampal neurogenesisRadoslaw Rola
Loma Linda U, CA
Radiat Res 164:556-60. 2005..These results indicate that high-LET radiation has a significant and long-lasting effect on the neurogenic population in the hippocampus that involves cell loss and changes in the microenvironment...
- Cytotoxic effects of low- and high-LET radiation on human neuronal progenitor cells: induction of apoptosis and TP53 gene expressionPeter Guida
Brookhaven Natl Lab, Upton, NY
Radiat Res 164:545-51. 2005..The RBE(max) for apoptosis 48 h after exposure was at least 3.4. In short, exposure to high-LET radiation results in a more efficient and greater induction of apoptosis in human neuronal progenitor cells than low-LET radiation...
- Clustered DNA damages induced by high and low LET radiation, including heavy ionsB M Sutherland
Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA
Phys Med 17:202-4. 2001..e. two independent hits are not required for cluster induction. Further, among all complex damages, double strand breaks comprise--at most-- ~20%, with the other clustered damages being at least 80%...
- Heavy ions, radioprotectors and genomic instability: implications for human space explorationJaroslaw Dziegielewski
Department of Radiation Oncology, University of Virginia, Charlottesville, VA, USA
Radiat Environ Biophys 49:303-16. 2010..Further, this review discusses some implications of radioprotection for the induction and/or propagation of genomic instability in the progeny of irradiated cells...
- Dose escalation study of carbon ion radiotherapy for locally advanced head-and-neck cancerJun-Etsu Mizoe
Hospital, Research Center of Charged Particle, National Institute of Radiological Sciences, Chiba, Japan
Int J Radiat Oncol Biol Phys 60:358-64. 2004..From the results of this study, it can be concluded that carbon ion radiotherapy will deliver a high local control rate without unacceptable injuries to the surrounding normal tissues...
- A system for three-dimensional dosimetric verification of treatment plans in intensity-modulated radiotherapy with heavy ionsC P Karger
Deutsches Krebsforschungszentrum, Abteilung Medizinische Physik, Heidelberg, Germany
Med Phys 26:2125-32. 1999..The system allows efficient verification and documentation of carbon ion fields and is in principle also applicable to intensity-modulated photon beams...
- Repair of DNA damage induced by accelerated heavy ions in mammalian cells proficient and deficient in the non-homologous end-joining pathwayRyuichi Okayasu
International Space Radiation Laboratory, National Institute of Radiological Sciences, Inage Ku, Chiba shi 263 8555, Japan
Radiat Res 165:59-67. 2006..This delay was further emphasized in NHEJ-defective 180BR cells. Our results indicate that high-LET radiation induces complex DNA damage that is not easily repaired or is not repaired by NHEJ even at low radiation doses such as 2 Gy...
- Outcomes of visual acuity in carbon ion radiotherapy: analysis of dose-volume histograms and prognostic factorsAzusa Hasegawa
Hospital, Charged Particle Research Center, National Institute of Radiological Sciences, Chiba, Japan
Int J Radiat Oncol Biol Phys 64:396-401. 2006..To analyze the tolerance dose for retention of visual acuity in patients with head-and-neck tumors treated with carbon ion radiotherapy...
- Temporally distinct response of irradiated normal human fibroblasts and their bystander cells to energetic heavy ionsNobuyuki Hamada
Department of Quantum Biology, Division of Bioregulatory Medicine, Gunma University Graduate School of Medicine, Maebashi, Gunma 371 8511, Japan
Mutat Res 639:35-44. 2008..Collectively, our results indicate that heavy ions inactivate clonogenic potential of bystander cells, and that the time course of the response to heavy ions ..
- Estimation of radiation tolerance to high LET heavy ions in an anhydrobiotic insect, Polypedilum vanderplankiMasahiko Watanabe
Anhydrobiosis Research Unit, National Institute of Agrobiological Sciences, Ohwashi, Tsukuba, Ibaraki, Japan
Int J Radiat Biol 82:835-42. 2006..between anhydrobiotic (dry) and non-anhydrobiotic (wet) samples after exposure to 1 - 7000 Gy of three types of heavy ions delivered from the azimuthally varying field (AVF) cyclotron with LET values ranging from 16.2 - 321 keV/microm...
- Microirradiation of cells with energetic heavy ionsA Hauptner
Physics Department E12, , 85748 Garching, Germany
Radiat Environ Biophys 42:237-45. 2004..In spite of single ion irradiation, we frequently observed split fluorescence foci which might be explained by small-scale chromatin movements...
- Minor contribution of direct ionization to DNA base damage inducedby heavy ionsThierry Douki
Laboratoire Lesions des Acides Nucleiques, Service de Chimie Inorganique et Biologique UMR E 3 CEA UJF, CEA DSM Département de Recherche Fondamentale sur la Matière Condensée, CEA Grenoble, Grenoble, France
Int J Radiat Biol 82:119-27. 2006The deleterious processes triggered by heavy ions on DNA were studied through the determination of the yield of a series of oxidized bases...
- The response of a spherical tissue-equivalent proportional counter to different ions having similar linear energy transferStephen B Guetersloh
Department of Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
Radiat Res 161:64-71. 2004..However, both values were within 15% of LET in all cases...
- HETC radiation transport code development for cosmic ray shielding applications in spaceL W Townsend
Department of Nuclear Engineering, University of Tennessee, Knoxville, TN 37996 2300, USA
Radiat Prot Dosimetry 116:135-9. 2005..missions, the Monte Carlo radiation transport code HETC is being extended to include transport of energetic heavy ions, such as are found in the galactic cosmic ray spectrum in space...
- Shielding and fragmentation studiesC Zeitlin
Lawrence Berkeley National Laboratory, MS74 197, Berkeley, CA 94720, USA
Radiat Prot Dosimetry 116:123-4. 2005..Measurement without a target present gives an indication of the level of contamination of the primary beam, which is also important in radiobiology experiments...
- Spectrum of complex DNA damages depends on the incident radiationMegumi Hada
Biology Department, Brookhaven National Laboratory, Upton, New York 11973-5000, USA
Radiat Res 165:223-30. 2006..The relative frequencies of DSBs compared to abasic and oxybase clusters were higher for the charged particles-including the high-energy, low-LET protons-than for the ionizing photons...
- Mice heterozygous for the ATM gene are more sensitive to both X-ray and heavy ion exposure than are wildtypesB V Worgul
Eye Radiation and Environmental Research Laboratory, Columbia University, New York, NY 10032, USA
Adv Space Res 35:254-9. 2005..The data show that heterozygosity for the ATM gene predisposes the eye to the cataractogenic influence of heavy ions and suggest that ATM heterozygotes in the human population may also be radiosensitive...
- Induced radioactivity in CU targets produced by high-energy heavy ions and the corresponding estimated photon dose ratesH Yashima
Cyclotron and Radioisotope Center, Tohoku University, Aramaki, Aoba, Sendai 980-8578, Japan
Radiat Prot Dosimetry 112:195-208. 2004..The residual activity and photon dose become larger with the increase in projectile energy per nucleon and the range of the projectile beam for the same projectile energy per nucleon...
- The physical and radiobiological basis of the local effect model: a response to the commentary by R. KatzM Scholz
GSI Biophysics, Darmstadt, Germany
Radiat Res 161:612-20. 2004..In contrast, e.g. for very heavy ions, there are significant discrepancies observed for the Katz approach...
- Conversion coefficients from fluence to effective dose for heavy ions with energies up to 3 GeV/AT Sato
Japan Atomic Energy Research Institute, Shirakata Shirane 2 4, Tokai mura, Naka gun, Ibaraki, 319 1195, Japan
Radiat Prot Dosimetry 106:137-44. 2003Radiological protection against high-energy heavy ions has been an essential issue in the planning of long-term space missions...
- Persistence of chromosome aberrations in mice acutely exposed to 56Fe+26 ionsJames D Tucker
Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202 3917, USA
Radiat Res 161:648-55. 2004..The health effects of exposure to high-LET radiation in humans on prolonged space flights should remain a matter of concern...
- Qualitative and quantitative difference in mutation induction between carbon- and neon-ion beams in normal human cellsMasao Suzuki
International Space Radiation Laboratory, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba shi 263, Japan
Biol Sci Space 17:302-6. 2003..The results suggest that different ion species may cause qualitative and quantitative difference in mutation induction even if the LET values are similar...
- ESR investigation of sucrose radicals produced by particle irradiationKouichi Nakagawa
RI Research Center, Fukushima Medical University, 1 Hikarigaoka, Fukushima, 960 1295, Japan
Spectrochim Acta A Mol Biomol Spectrosc 60:1315-8. 2004..The impact of heavy ions on sucrose produced sucrose radicals, which were measured by ESR...
- LET and ion-species dependence for cell killing and mutation induction in normal human fibroblastsChizuru Tsuruoka
International Space Radiation Laboratory, National Institute Radiological Science
Biol Sci Space 17:185-6. 2003..These results suggested that different biological endpoints may be suitable for different physical parameter, which represent the track structure of energy deposition of ion beams...
- Chromosome aberrations induced in human lymphocytes by heavy charged particles in track segment modeM Di Giorgio
Autoridad Regulatoria Nuclear, Av. del Libertador 8250, CP: C1429BNP, Ciudad de Buenos Aires, Argentina
Radiat Prot Dosimetry 108:47-53. 2004..The existence or otherwise of a beta component of the dose-response at these radiation qualities has important consequences for modelling mechanisms of aberration induction by radiation...
- Effects of low dose particle radiation to mouse neonatal neurons in cultureKumie Nojima
Brookhaven Natl Lab, Upton, NY
Biol Sci Space 17:263-4. 2003..dose heavy particle radiation to CNS system, we adopted mouse neonatal brain cells in culture being exposed to heavy ions generated by HIMAC at NIRS and BNL. The applied dose varied from 0.05 Gy up to 2.0 Gy...
- Chromatin organization contributes to non-randomly distributed double-strand breaks after exposure to high-LET radiationIrina Radulescu
Division of Biomedical Radiation Sciences, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
Radiat Res 161:1-8. 2004..However, our data suggest a complex interaction between track structure and chromatin organization over several levels...
- Introduction of a thermal response to the DSTL PADC personal neutron dosemeterR G Mills
Department of Physics, University of Surrey, Guildford GU2 5XH, UK
Radiat Prot Dosimetry 110:309-14. 2004....
- Dosimetry of heavy charged particles with thermoluminescence detectors--models and applicationsP Olko
Institute of Nuclear Physics, PL 31 342 Krakow, Poland
Radiat Prot Dosimetry 110:315-8. 2004..0 and 1.45 and, for Z > 1, between 1.3 and 2. These relationships can be applied to derive information about the 'effective LET' in an unknown HCP field and to correct the TLD readings for dose evaluation...
- Early and delayed reproductive death in human cells exposed to high energy iron ion beamsD Bettega
Dipartimento di Fisica, Universita degli Studi di Milano and INFN Sezione di Milano, Milano, Italy
Adv Space Res 35:280-5. 2005..6 and 3 for early and delayed reproductive death, respectively. Analysis of the fluence-effect curves shows that the cross-sections for early and delayed inactivation increase with increasing LET up to 442 keV/micrometers...
- Ground-based research with heavy ions for space radiation protectionM Durante
Department of Physics, University Federico II, Monte S Angelo, Via Cintia, Naples, Italy
Adv Space Res 35:180-4. 2005..High quality accelerator-based research with heavy ions will continue to be the main source of knowledge of space radiation health effects and will lead to reductions ..
- Simulations of an accelerator-based shielding experiment using the particle and heavy-ion transport code system PHITST Sato
JAERI, Tokai mura, Japan
Adv Space Res 35:208-13. 2005..for calculating total reaction cross sections, and addition of routines for calculating elastic scattering of heavy ions, and inclusion of radioactivity and burn up processes...
- Fragmentation of 1 GeV/nucleon iron ions in thick targets relevant for space explorationC La Tessa
Chalmers University of Technology, Nuclear Science and Engineering, Gothenburg, Sweden
Adv Space Res 35:223-9. 2005....
- Fragmentation studies of relativistic iron ions using plastic nuclear track detectorsP Scampoli
Department of Physics, University Federico II, and INFN, Sezione di Napoli, Monte S. Angelo, Via Cintia, Napoli, Italy
Adv Space Res 35:230-5. 2005..These physical measurements will be used to characterize the beam used in parallel biological experiments...
- High LET-induced H2AX phosphorylation around the Bragg curveN Desai
Adv Space Res 35:236-42. 2005....
- DNA DSB induced by iron ions in human fibroblasts: LET dependence and shielding efficiencyG Esposito
Laboratorio di Fisica, Technology and Health Department, Istituto Superiore di Sanita, Rome, Italy
Adv Space Res 35:243-8. 2005..Protection is only observed at high iron ions energy, especially at 5 GeV/u, where PMMA shield gives higher protection compared to Al or Pb shields of the same thickness expressed in g/cm2...
- Tumor induction in mice locally irradiated with carbon ions: a retrospective analysisKoichi Ando
Heavy Ion Radiobiology Research Group, National Institute of Radiological Sciences, Chiba, Japan
J Radiat Res 46:185-90. 2005..2 for tumor induction and 1.9 for early skin reaction. We conclude that risk of secondary tumor induction by carbon-ion radiotherapy would not be seriously higher than anticipated...
- Chromosome aberration yields and apoptosis in human lymphocytes irradiated with Fe-ions of differing LETR Lee
Biophysik, , Darmstadt, Germany
Adv Space Res 35:268-75. 2005..The significance of this observation for the estimation of the health risk associated with space radiation remains to be elucidated...
- Cellular parameters for track structure modeling of radiation hazard in spaceM P R Waligorski
Center of Oncology, Krakow, Poland
Adv Space Res 34:1378-82. 2004..The "synergistic" effect of simultaneous charged particle transfers is accounted for by the "track overlap" mode inherent in the model of Katz...
- Instrumentation for investigation of the depth-dose distribution by the Liulin-5 instrument of a human phantom on the Russian segment of ISS for estimation of the radiation risk during long term space flightsJ Semkova
Solar Terrestrial Influences Laboratory, Bulgarian Academy of Sciences, Sofia, Bulgaria
Adv Space Res 34:1297-301. 2004..Presented are the test results of the prototype unit. The spherical phantom will be flown on the ISS in 2004 year and Liulin-5 experiment is planned for 2005 year...
- Responses of a diamond detector to high-LET charged particlesMakoto Sakama
Tokyo Institute of Technology, 4259, Nagatsuta cho, Midori ku, Yokohama 226 8502, Japan
Phys Med Biol 50:2275-89. 2005The responses of a commercial diamond detector (type 60003, PTW-Freiburg) to several heavy ions were examined...
- The LET spectra at different penetration depths along secondary 9C and 11C beamsQ Li
Department of Medical Physics, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Anagawa 4 9 1, Inage Ku, Chiba shi, Chiba 263 8555, Japan
Phys Med Biol 49:5119-33. 2004..It is still hard to appreciate the potential of 9C beams in cancer therapy based on the present LET spectrum measurement, but it provides a substantial basis for upcoming radiobiological experiments...
- Measurements of neutron effective doses and attenuation lengths for shielding materials at the heavy-ion medical accelerator in ChibaYoshikazu Kumamoto
National Institute of Radiological Sciences, 4 9 1, Anagawa, Inaga Ward, Chiba City, Japan, 263 8555
Health Phys 88:469-79. 2005....
- Bubble detector characterization for space radiationA R Green
Royal Military College of Canada, Kingston, ON, Canada
Acta Astronaut 56:949-60. 2005....
- Effect of high-dose irradiation on the optically stimulated luminescence of Al2O3:CE G Yukihara
Department of Physics, Arkansas Oklahoma Center for Space and Planetary Sciences, Oklahoma State University, Stillwater, OK 74078 3072, USA
Radiat Meas 38:317-30. 2004..Finally, the implication of these results for the dosimetry of heavy charged particles is discussed...
- Response of thermoluminescent detectors to charged particles and to neutronsFrantisek Spurny
Nuclear Physics Institute Department of Radiation Dosimetry, Academy of Sciences of the Czech Republic, Praha, Czech Republic
Radiat Meas 38:407-12. 2004..As far as eta is concerned, the same tendencies were observed as for charged particles, i.e. when average LET of secondary particles formed in a TLD increases, their eta generally decreases...
- Effects of heavy ion to the primary [correction of rimary] culture of mouse brain cellsKumie Nojima
Brookhaven Nat'l Lab, Upton, NY
Biol Sci Space 18:114-5. 2004..dose heavy particle radiation to CNS system, we adopted mouse neonatal brain cells in culture being exposed to heavy ions by HIMAC at NIRS and NSRL at BNL. The applied dose varied from 0.05 Gy up to 2.0 Gy...
- Investigation of heavy-ion-induced sucrose radicals by electron paramagnetic resonanceKouichi Nakagawa
RI Research Center, Fukushima Medical University, 1 Hikarigaoka, Fukushima, 960 1295, Japan
Radiat Res 164:336-8. 2005..In addition, the EPR response had a linear relationship with dose in the dose range of 5-60 Gy. Thus the present EPR results show that sucrose can be used to monitor the ionizing particle based on the radical yield...
- LET and ion-species dependence for mutation induction and mutation spectrum on hprt locus in normal human fibroblastsChizuru Tsuruoka
International Space Radiation Laboratory, National Institute Radiological Sciences
Biol Sci Space 18:188-9. 2004..These results suggested that quantitative and qualitative difference in mutation occurred when using different ion species even if similar LET values...
- Mutations induced by heavy charged particlesFumio Yatagai
Advanced Development and Support Center, RIKEN Institute, Wako Shi, Saitama, Japan
Biol Sci Space 18:224-34. 2004..Finally, applications of mutation detection systems for studies in space (section 3) are described, in which the carcinogenic effects of space environmental radiation are considered...
- Analysis of secondary electron emission spectra of equal-LET protons and alpha particles for purposes of radiation quality and spaceflight hazard assessmentP A Craven
Institute of Cancer Research, University of London, London, UK
Adv Space Res 35:300-4. 2005..Such a method for numerically assessing radiation quality may have implications for procedures for heavy ion protection in space at low doses and for understanding the initial mechanisms of radiation action...
- Overview of secondary neutron production relevant to shielding in spaceL Heilbronn
MS 74 197, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
Radiat Prot Dosimetry 116:140-3. 2005..Stopping target yields and cross section measurements conducted at particle accelerators using heavy ions with energies > 100 MeV per nucleon are discussed.
- RBE of radiations in space and the implications for space travelA A Edwards
National Radiological Protection Board, Chilton, Didcot, Oxon, UK
Phys Med 17:147-52. 2001..From this sparse information, pragmatic choices need to be made for application to protection in space. The data are reviewed and the bases for the pragmatic choices discussed...
- COST-ENLIGHT strategic workshop on hadron (particle) therapy, CERN, Geneva, 3-4 May 2007R E Taylor
Swansea University, South West Wales Cancer Centre, Singleton Hospital, Swansea, UK
Br J Radiol 81:169-71. 2008..This comprises a series of seven work packages, which will be a focus for European collaboration...
- Cosmic ray measurements at aircraft altitudes and comparison with predictions of computer codesD Zhou
Dublin Institute for Advanced Studies, Astrophysics Section, Dublin, Ireland
Adv Space Res 32:47-52. 2003..The detectors were calibrated using energetic heavy ions. Data obtained were compared with the predictions of the EPCARD and CARI-6 codes...
- High relative biologic effectiveness of carbon ion radiation on induction of rat mammary carcinoma and its lack of H-ras and Tp53 mutationsTatsuhiko Imaoka
Experimental Radiobiology for Children s Health Research Group, Anagawa, Chiba, Japan
Int J Radiat Oncol Biol Phys 69:194-203. 2007..We undertook the present study to clarify the RBE of therapeutic carbon ion radiation and molecular changes that occur in the rat mammary cancer model...
- Mammalian cells loaded with platinum-containing molecules are sensitized to fast atomic ionsN Usami
Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization, Oho, Tsukuba, Japan
Int J Radiat Biol 84:603-11. 2008..The experiment consists in irradiating by fast ions cultured cells previously exposed to dichloroterpyridine Platinum (PtTC) and analyzing cell survival by a colony-forming assay...
- Monitoring the irradiation field of 12C and 16O SOBP beams using positron emitters produced through projectile fragmentation reactionsTaku Inaniwa
Department of Energy Sciences, Tokyo Institute of Technology, 4259 Nagatsuta cho, Midori ku, Yokohama 226 8502, Japan
Phys Med Biol 53:529-42. 2008In order to effectively utilize the prominent properties of heavy ions in radiotherapy, it is important to evaluate both the position of the field irradiated with incident ions and the absorbed dose distribution in a patient's body...
- Visualizing the dose distribution and linear energy transfer by 1D and 2D ESR imaging: a potassium dithionate dosimeter irradiated with C6+ and N7+ ionsHakan Gustafsson
J Phys Chem B 112:8437-42. 2008..and linear energy transfer (LET) in a potassium dithionate, K2S2O6 (PDT), dosimeter irradiated with the heavy ions C(6+) and N(7+)...
- LET distributions from CR-39 plates on Space Shuttle missions STS-84 and STS-91 and a comparison of the results of the CR-39 plates with those of RRMD-II and RRMD-III telescopesH Tawara
High Energy Accelerator Research Organization, Radiation Science Center, Oho 1 1, Tsukuba shi, Ibaraki 305 0801, Japan
Radiat Meas 35:119-26. 2002....
- Ion-kill dosimetryR Katz
University of Nebraska, Lincoln, NE 68588-0111, USA
Phys Med 17:164-5. 2001..We identify that difference as 'ion kill', associated with the spectrum of z/beta in the radiation field, whose measurement we label 'ion-kill dosimetry'...
- Doses and LET spectra in the beam of 12C with energy 500 MeV amu-1Iva Jadrnícková
Department of Radiation Dosimetry, Nuclear Physics Institute AS CR, Na Truhlářce 39 64, 18086 Prague 8, Czech Republic
Radiat Prot Dosimetry 122:488-90. 2006..Data measured by means of a diamond detector and a spectrometer of linear energy transfer (LET) based on chemically etched track detectors are presented, analysed and discussed. LET spectra are also calculated by program SRIM...
- Experimental fragmentation studies with 12C therapy beamsE Haettner
Biophysik, Gesellschaft fur Schwerionenforschung, Planckstr 1, D 64291 Darmstadt, Germany
Radiat Prot Dosimetry 122:485-7. 2006..The preliminary results include energy- and angular distributions, fragment yields, build-up curves and attenuation of the primary carbon projectiles...
- Dose equivalents inside the MIR Space Station measured by the combination of CR-39 plates and TLDs and their comparison with those on Space Shuttle STS-79, -84 and -91 missionsTadayoshi Doke
Tsukuba Space Center, National Space Development Agency of Japan, Ibaraki, Japan
Radiat Meas 35:505-10. 2002..Finally, the differences between our results and those obtained by another group using passive dosimeters on the MIR are discussed...
- Simultaneous exposure of mammalian cells to heavy ions and X-raysY Furusawa
National Institute of Radiological Sciences, Chiba, Japan
Adv Space Res 30:877-84. 2002..of mixed high-/low-LET radiation fields, mammalian cells were exposed in vitro simultaneously to X-rays and heavy ions, accelerated at the HIMAC accelerator. X-ray doses ranged from 1 to 11 Gy...
- Carbon beam therapy overcomes the radiation resistance of uterine cervical cancer originating from hypoxiaTakashi Nakano
Research Center Hospital of Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
Clin Cancer Res 12:2185-90. 2006..However, no proof of this effect has been provided by clinical trials and related clinical research. Hence, we investigated the radiation biological aspects of high LET carbon beam therapy on cervical cancer...
- Repair of skin damage during fractionated irradiation with gamma rays and low-LET carbon ionsKoichi Ando
Heavy Ion Radiobiology Research Group, National Institute of Radiological Sciences, Chiba, Japan
J Radiat Res 47:167-74. 2006....
- Confocal fluorescent imaging of tracks from heavy charged particles utilising new Al2O3:C,Mg crystalsMark S Akselrod
Landauer, Inc, Stillwater Crystal Growth Division, 723 1 2 Eastgate Road, Stillwater, OK 74074, USA
Radiat Prot Dosimetry 119:357-62. 2006..Fast neutrons were detected using recoil protons produced in a polyethylene radiator installed in front of the crystalline detector. Three-dimensional reconstruction of a recoil proton propagating through the crystal was demonstrated...
- Microbeams of heavy charged particlesYasuhiko Kobayashi
Research Group for Biotechnology Development, Japan Atomic Energy Research Institute JAERI Takasaki, Takasaki, Gunma, Japan
Biol Sci Space 18:235-40. 2004..These are the first studies in which single-ion direct hit effect and the bystander effect have been investigated using a high-LET heavy particle microbeam...
- Radiobiology with heavy charged particles: a historical reviewL D Skarsgard
Department of Medical Biophysics, B C Cancer Research Centre, Vancouver, Canada
Phys Med 14:1-19. 1998..synchrotrons and linear accelerators, culminating in the BEVALAC, which provided the first source of very heavy ions (helium to argon) to be used clinically, beginning in 1975...
- Single track effects, Biostack and risk assessmentS B Curtis
Lawrence Berkeley Laboratory, University of California 94720, USA
Radiat Meas 23:5-8. 1994..It is also pointed out, however, that there may be unique effects from single tracks of heavy ions that do not occur from light-ion tracks. For such effects, the concepts of both RBE and RPPE lose their meaning.
- Radon exposure of the skin: I. Biological effectsM W Charles
School of Physics and Astronomy, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
J Radiol Prot 27:231-52. 2007..Accelerator generated high energy helium and heavy ions can produce skin cancer in rodents at high doses, but only if they penetrate deep into the dermis...
- Absorption characteristics of protons and photons in tissueJohn F Dicello
Department of Radiation Medicine, Loma Linda University, Loma Linda, California, USA
Technol Cancer Res Treat 6:25-9. 2007..Prior to initiation of clinical trials with protons, neutrons, pions, and heavy ions, it was generally believed that such particles might have a therapeutic advantage resulting from their greater ..
- Astrobiological aspects of the mutagenesis of cosmic radiation on bacterial sporesRalf Moeller
German Aerospace Center DLR, Institute of Aerospace Medicine, Radiation Biology Department, Cologne, Germany
Astrobiology 10:509-21. 2010..B. subtilis spores were irradiated with X-rays and accelerated heavy ions (helium, carbon, silicon and iron) in the linear energy transfer (LET) range of 2-200 keV/mum...
- Activation of the nuclear factor κB pathway by heavy ion beams of different linear energy transferChristine E Hellweg
German Aerospace Centre, DLR, Institute of Aerospace Medicine, Radiation Biology, Linder Hohe, Koln, Germany
Int J Radiat Biol 87:954-63. 2011..Few data on gene transcription activation by different heavy ions are available, suggesting a dependence on linear energy transfer...
- Non-targeted effects and the dose response for heavy ion tumor inductionFrancis A Cucinotta
NASA, Lyndon B Johnson Space Center, Space Radiation Program, 2101 NASA Parkway, Mail Code SK, Houston, TX 77058, USA
Mutat Res 687:49-53. 2010..understanding of cancer risks from galactic cosmic rays (GCR), which are comprised of high-energy protons and heavy ions. The most comprehensive data set for tumor induction by heavy ions is the induction of Harderian gland tumors in ..
- Radiation tolerance in the tardigrade Milnesium tardigradumDaiki D Horikawa
Graduate School of Environmental Earth Science, Hokkaido University, Sapporo, Japan
Int J Radiat Biol 82:843-8. 2006..In this study, we investigated tolerance of the tardigrade, Milnesium tardigradum, against gamma-rays and heavy ions by determining short-term or long-term survival, and reproductive ability after irradiation.
- Relevance of oxygen in radiation oncology. Mechanisms of action, correlation to low hemoglobin levelsM Molls
Klinik und Poliklinik für Strahlentherapie und Radiologische Onkologie, Technische Universitat Munchen
Strahlenther Onkol 174:13-6. 1998..This led to the evaluation of the oxygen enhancement ratio (OER) for photons (X-rays), neutrons and heavy ions. It was found that the OER for conventional radiation therapy (RT) with photons is much higher (about 3) than ..
- Radiation-quality dependent cellular response in mutation induction in normal human cellsMasao Suzuki
Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
J Radiat Res 50:395-9. 2009..irradiations of different radiation types, such as gamma rays, neutrons and high linear energy transfer (LET) heavy ions. The cells were pretreated with low-dose (rate) or low-fluence irradiations (approximately 1 mGy/7-8 h) of 137Cs ..
- Studies on biological effects of ion beams on lethality, molecular nature of mutation, mutation rate, and spectrum of mutation phenotype for mutation breeding in higher plantsAtsushi Tanaka
Quantum Beam Science Directorate, Japan Atomic Energy Agency, Takasaki, Gunma, Japan
J Radiat Res 51:223-33. 2010Recently, heavy ions or ion beams have been used to generate new mutants or varieties, especially in higher plants...
- Observation of DNA damage of human hepatoma cells irradiated by heavy ions using comet assayLi Mei Qiu
Institute of Modern Physics, The Chinese Academy of Sciences, Lanzhou 730000, Gansu Province, China
World J Gastroenterol 9:1450-4. 2003Now many countries have developed cancer therapy with heavy ions, especially in GSI (Gesellschaft f r Schwerionenforschung mbH, Darmstadt, Germany), remarkable results have obtained, but due to the complexity of particle track structure, ..
- Visualization of particle flux in the human body on the surface of MarsPremkumar B Saganti
Lockheed Martin Space Operations, NASA JSC, Houston, TX 77058, USA
J Radiat Res 43:S119-24. 2002..a given galactic cosmic ray (GCR) environment, information on the particle flux of protons, alpha particles, and heavy ions, that varies with respect to the topographical altitude on the Martian surface, are needed for planning ..
- Initial recombination in a parallel-plate ionization chamber exposed to heavy ionsT Kanai
Therapeutic Beam Assessment Office, Research Center of Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
Phys Med Biol 43:3549-58. 1998..002 V(-1) cm. The gradient of the line increases as the LET of the heavy ions increases. A strong LET dependence of the gradient was observed in air and carbon dioxide...
- Genome-wide expression changes in Saccharomyces cerevisiae in response to high-LET ionizing radiationSatomi Mizukami-Murata
Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology, 3A Tsukuba West, 16 1, Onogawa, Tsukuba, Ibaraki 305 8569, Japan
Appl Biochem Biotechnol 162:855-70. 2010..IR), we investigated global gene expression in yeast irradiated by three types of high-LET IR (fast neutrons, heavy ions, and thermal neutrons) and gamma rays using DNA microarray analysis...
- Pharmacological agents for the prevention and treatment of toxic radiation exposure in spaceflightJohn Langell
Acute Care Surgery, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA
Aviat Space Environ Med 79:651-60. 2008..high cost of launching these heavy structures into space and their inability to provide adequate shielding from heavy ions at a feasible shield thickness...
- Induction and repair of DNA strand breaks in bovine lens epithelial cells after high LET irradiationC Baumstark-Khan
Institute of Aerospace Medicine, German Aerospace Center, Koln, Germany
Adv Space Res 31:1583-91. 2003..cultured diploid bovine lens epithelial cells exposed to different LET irradiation to either 300 kV X-rays or to heavy ions at the UNILAC accelerator at GSI. Accelerated ions from Z=8 (O) to Z=92 (U) were used...
- Diffusivity measurement of heavy ions in Wyoming montmorillonite gels by X-ray computed tomographyYoshito Nakashima
Exploration Geophysics Research Group, National Institute of Advanced Industrial Science and Technology, Central 7, Higashi 1 1 1, Tsukuba, Ibaraki 305 8567, Japan
J Contam Hydrol 61:147-56. 2003Medical X-ray computed tomography (CT) was applied to the measurement of the diffusion coefficients of heavy ions in an artificial barrier material for the disposal of nuclear wastes...
- Induction and processing of oxidative clustered DNA lesions in 56Fe-ion-irradiated human monocytesDoug Tsao
Biology Department, East Carolina University, Greenville, North Carolina 27858 4353, USA
Radiat Res 168:87-97. 2007Space and cosmic radiation is characterized by energetic heavy ions of high linear energy transfer (LET)...
- Monte Carlo track structure studies of energy deposition and calculation of initial DSB and RBEH Nikjoo
MRC Radiobiology Unit, Didcot, U K
Adv Space Res 14:161-80. 1994..Tracks of monoenergetic heavy ions and electrons were constructed by following the molecular interaction-by-interaction histories of the particles ..
- Complex chromosomal rearrangements induced in vivo by heavy ionsM Durante
Department of Physics, University Federico II, Naples, Italy
Cytogenet Genome Res 104:240-4. 2004..Complex chromosomal rearrangements do not represent a practical biomarker of radiation quality in our test subjects...
- Physical and biological organ dosimetry analysis for international space station astronautsFrancis A Cucinotta
NASA, Space Radiation Program, Lyndon B Johnson Space Center, Houston, Texas 77058, USA
Radiat Res 170:127-38. 2008..is difficult in space due to the complexity of the space radiation environment, which consists of protons, heavy ions and secondary neutrons, and the modification of these radiation types in tissue as well as limitations in ..
- LET dependence of lethality in Arabidopsis thaliana irradiated by heavy ionsNaoya Shikazono
Department of Radiation Research for Environment and Resources, Takasaki Radiation Chemistry Research Establishment, Japan Atomic Energy Research Institute JAERI, Takasaki, Gunma, 370 1292, Japan
Radiat Environ Biophys 41:159-62. 2002To clarify the effect of heavy ions in plants, dry seeds of Arabidopsis were irradiated with carbon, neon, and argon ions with various linear energy transfer (LET) values...
- Heavy ion-induced DNA double-strand breaks in yeastJürgen Kiefer
Strahlenzentrum der Justus Liebig Universität, Leihgesterner Weg 217, 35392 Giessen, Germany
Radiat Res 157:141-8. 2002..gel electrophoresis (PFGE) after the cells had been exposed on membrane filters to a variety of energetic heavy ions with values of linear energy transfer (LET) ranging from about 2 to 11,500 keV/microm, (241)Am alpha particles, ..
- Diverse plasma populations and structures in Jupiter's magnetotailD J McComas
Southwest Research Institute, 6220 Culebra Road, San Antonio, TX 78238, USA
Science 318:217-20. 2007Jupiter's magnetotail is the largest cohesive structure in the solar system and marks the loss of vast numbers of heavy ions from the Jupiter system...
- In vivo and in vitro measurements of complex-type chromosomal exchanges induced by heavy ionsK George
Wyle Life Sciences, Houston, TX 77058, USA
Adv Space Res 31:1525-35. 2003b>Heavy ions are more efficient in producing complex-type chromosome exchanges than sparsely ionizing radiation, and this can potentially be used as a biomarker of radiation quality...
- Mutation induction in human lymphoid cells by energetic heavy ionsA Kronenberg
Life Sciences Division, Lawrence Berkeley Laboratory, Berkeley, CA 94720, USA
Adv Space Res 14:339-46. 1994..In the series of studies presented herein, the mutagenic effectiveness of high energy heavy ions is examined using human B-lymphoblastoid cells across an LET range from 32keV/micrometer to 190 keV/micrometer...
- Comparative analysis of cell killing and autosomal mutation in mouse kidney epithelium exposed to 1 GeV/nucleon iron ions in vitro or in situAmy Kronenberg
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
Radiat Res 172:550-7. 2009Astronauts receive exposures to high-energy heavy ions from galactic cosmic radiation...
- Effects of radiation upon the light-sensing elements of the retina as characterized by scanning electron microscopyM J Malachowski
Donner Laboratory, Lawrence Berkeley Laboratory, Berkeley, Calif, USA
Life Sci Space Res 15:175-81. 1977..Accelerated heavy ions of helium and neon from the Berkeley Bevalac were used...
- Assessment of DNA damage induced by high-LET ions in human lymphocytes using the comet assayI Testard
CIRIL, rue Claude Bloch, BP 5133, F 14070, Caen, France
Mutat Res 448:105-15. 2000..Four experiments with heavy ions (Ar, C and U), as well as gamma-ray exposure, were conducted to enable comparisons...
- Production of neutrons from interactions of GCR-like particlesL Heilbronn
Lawrence Berkeley Laboratory, Berkeley, CA 94720, USA
Acta Astronaut 42:363-73. 1998..transport problem, and we point out how neutron production from protons is different than neutron production from heavy ions. We also make comparisons of one the heavy-ion data sets with Boltzmann-Uehling-Uhlenbeck (BUU) calculations.
- Radiation-Induced Mutagenesis and Apoptotic RegulationAmy Kronenberg; Fiscal Year: 2006..It is the secondary mutations that lead to advance, aggressive disease in people. ..
- RADIATION BIOLOGY TRAINING GRANTAnn Kennedy; Fiscal Year: 2007..It is expected that graduates of the training program will continue with their research and academic careers in radiation biology and oncology. ..
- Chemotherapy with injectable microdropletsFRANCESCO D ERRICO; Fiscal Year: 2007....
- Role of TGFBI gene in cell proliferation and tumor progressionYongliang Zhao; Fiscal Year: 2010....
- Prediction of Second Cancer Risks for Children Treated with Proton - vs. - PhotonWayne D Newhauser; Fiscal Year: 2010..In the future, we expect that the lower-risk treatments will result in fewer second cancers and this will translate into longer, higher-quality lives for survivors of childhood cancer (presently 270,000 persons in the United States). ..
- Eighth International Workshop on Radiation Damage to DNAKATHRYN HELD; Fiscal Year: 2004..abstract_text> ..
- Electron Transport in Tissue-Like MaterialLARRY TOBUREN; Fiscal Year: 2004..abstract_text> ..
- MECHANISMS FOR OXIDATIVE STRESS INDUCED APOPTOSISKATHRYN HELD; Fiscal Year: 1999..g., to enhance cell killing in tumor cells or prevent cell killing in AIDS, autoimmune diseases, neurodegenerative diseases, etc., where oxidative stress may play a role. ..
- HIGH ENERGY IONS AND GENOMIC INSTABILITYEric Hall; Fiscal Year: 2001....
- Magnetic Flow Sorter for Pancreatic Islet IsolationPaul Todd; Fiscal Year: 2005..abstract_text> ..
- ENHANCED APOPTOSIS BY TARGETING PROTEIN REDOX STATUSMohan Natarajan; Fiscal Year: 2009..abstract_text> ..
- Magnetic Sorter Channels for Stem CellsPaul Todd; Fiscal Year: 2006..abstract_text> ..
- ENHANCED APOPTOSIS BY TARGETING PROTEIN REDOX STATUSMohan Natarajan; Fiscal Year: 2007..Ultimately, the outcomes should establish a rationale for combining targeting of redox controlling proteins with other specific anti-cancer drugs to maximize apoptosis in cancer cells that are resistant to DNA damaging agents. ..
- Electron Transport in Tissue-Like MaterialLARRY TOBUREN; Fiscal Year: 2007..The results will enhance our effort to establish clinically relevant radiation treatment with a better understanding of potential damage to healthy tissue. ..