heavy ions

Summary

Summary: Positively-charged atomic nuclei that have been stripped of their electrons. These particles have one or more units of electric charge and a mass exceeding that of the Helium-4 nucleus (alpha particle).

Top Publications

  1. doi Heavy ion carcinogenesis and human space exploration
    Marco Durante
    Biophysics group at GSI, Planckstrasse 1, 64291 Darmstadt, Germany
    Nat Rev Cancer 8:465-72. 2008
  2. doi Proton vs carbon ion beams in the definitive radiation treatment of cancer patients
    Herman Suit
    Department of Radiation Oncology, Boston, MA, USA
    Radiother Oncol 95:3-22. 2010
  3. ncbi Contribution of indirect action to radiation-induced mammalian cell inactivation: dependence on photon energy and heavy-ion LET
    Atsushi Ito
    Course of Energy Engineering, Department of Applied Science, School of Engineering, Tokai University, Hiratsuka shi, Kanagawa 259 1292, Japan
    Radiat Res 165:703-12. 2006
  4. ncbi Redox changes induced in hippocampal precursor cells by heavy ion irradiation
    C L Limoli
    Department of Radiation Oncology, University of California Irvine, Medical Sciences I, Room B 149, Irvine, CA 92697 2695, USA
    Radiat Environ Biophys 46:167-72. 2007
  5. ncbi Spatiotemporal analysis of DNA repair using charged particle radiation
    F Tobias
    GSI Helmholtzzentrum fur Schwerionenforschung, Biophysik, Planckstrasse 1, D 64291 Darmstadt, Germany
    Mutat Res 704:54-60. 2010
  6. ncbi Repair of DNA damage induced by accelerated heavy ions in mammalian cells proficient and deficient in the non-homologous end-joining pathway
    Ryuichi Okayasu
    International Space Radiation Laboratory, National Institute of Radiological Sciences, Inage Ku, Chiba shi 263 8555, Japan
    Radiat Res 165:59-67. 2006
  7. ncbi Recent advances in the biology of heavy-ion cancer therapy
    Nobuyuki Hamada
    Radiation Safety Research Center, Nuclear Technology Research Laboratory, Central Research Institute of Electric Power Industry, Komae, Tokyo, Japan
    J Radiat Res 51:365-83. 2010
  8. ncbi A murine model for bone loss from therapeutic and space-relevant sources of radiation
    S A Hamilton
    Dept of Bioengineering, Clemson University, Clemson, SC 29634, USA
    J Appl Physiol 101:789-93. 2006
  9. ncbi Treatment planning for the layer-stacking irradiation system for three-dimensional conformal heavy-ion radiotherapy
    Nobuyuki Kanematsu
    Department of Medical Physics, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba 263 8555, Japan
    Med Phys 29:2823-9. 2002
  10. ncbi Heavy ion beam irradiation regulates the mRNA expression in megakaryocytopoiesis from human hematopoietic stem/progenitor cells
    Satoru Monzen
    Department of Radiological Life Sciences, Hirosaki University Graduate School of Health Sciences, Hirosaki, Japan
    J Radiat Res 50:477-86. 2009

Research Grants

  1. EFFECTS OF RADIATION ON MAMALIAN CELLS
    John Little; Fiscal Year: 1990
  2. HEAVY-ION MUTAGENESIS
    Amy Kronenberg; Fiscal Year: 1990
  3. HEAVY PARTICLES IN RADIOTHERAPY: A COMPARATIVE STUDY
    MUDUNDI RAJU; Fiscal Year: 1980
  4. HEAVY ION RADIOBIOLOGY RELATED TO ONCOLOGY
    CORNELIUS TOBIAS; Fiscal Year: 1980
  5. DEVELOPMENTAL GENETICS WITH AN INDUCIBLE GENE SYSTEM
    Michael Freeling; Fiscal Year: 1980
  6. THE RESPONSE OF A RAT RHABDOMYOSARCOMA TO HEAVY IONS
    STANLEY CURTIS; Fiscal Year: 1980
  7. AGING, RADIATION & DNA DAMAGE IN NONDIVIDING TISSUE
    JOHN LETT; Fiscal Year: 1980
  8. FRAGMENTATION OF HEAVY IONS FOR BIOMEDICAL RESEARCH
    PIYARE JAIN; Fiscal Year: 1980
  9. AAPM CHARGED PARTICLE BEAM DOSIMETRY TASK GROUP
    Alfred Smith; Fiscal Year: 1980
  10. GEV HEAVY-ION AND 200 KV X-RAY EXCITATION OF DNA
    Malcolm Daniels; Fiscal Year: 1980

Detail Information

Publications241 found, 100 shown here

  1. doi Heavy ion carcinogenesis and human space exploration
    Marco Durante
    Biophysics group at GSI, Planckstrasse 1, 64291 Darmstadt, Germany
    Nat Rev Cancer 8:465-72. 2008
    ..Here, we describe how research in cancer radiobiology can support human missions to Mars and other planets...
  2. doi Proton vs carbon ion beams in the definitive radiation treatment of cancer patients
    Herman Suit
    Department of Radiation Oncology, Boston, MA, USA
    Radiother Oncol 95:3-22. 2010
    ..The principal differences are LET, low for (1)H and high for (12)C, and a narrower penumbra of (12)C beams. Were (12)C to yield a higher TCP for a defined NTCP than (1)H therapy, would LET, fractionation or penumbra width be the basis?..
  3. ncbi Contribution of indirect action to radiation-induced mammalian cell inactivation: dependence on photon energy and heavy-ion LET
    Atsushi Ito
    Course of Energy Engineering, Department of Applied Science, School of Engineering, Tokai University, Hiratsuka shi, Kanagawa 259 1292, Japan
    Radiat Res 165:703-12. 2006
    ..4 keV to 1.25 MeV and for heavy ions over the linear energy transfer (LET) range from 20 keV/microm to 440 keV/microm by applying competition ..
  4. ncbi Redox changes induced in hippocampal precursor cells by heavy ion irradiation
    C L Limoli
    Department of Radiation Oncology, University of California Irvine, Medical Sciences I, Room B 149, Irvine, CA 92697 2695, USA
    Radiat Environ Biophys 46:167-72. 2007
    ..Given the prevalence of heavy ions in space and the duration of interplanetary travel, these data suggest that astronauts are at risk for ..
  5. ncbi Spatiotemporal analysis of DNA repair using charged particle radiation
    F Tobias
    GSI Helmholtzzentrum fur Schwerionenforschung, Biophysik, Planckstrasse 1, D 64291 Darmstadt, Germany
    Mutat Res 704:54-60. 2010
    ..With the help of the microbeam, geometrical patterns of traversing ions can be applied facilitating the analysis of spatial organisation of repair...
  6. ncbi Repair of DNA damage induced by accelerated heavy ions in mammalian cells proficient and deficient in the non-homologous end-joining pathway
    Ryuichi Okayasu
    International Space Radiation Laboratory, National Institute of Radiological Sciences, Inage Ku, Chiba shi 263 8555, Japan
    Radiat Res 165:59-67. 2006
    ..This delay was further emphasized in NHEJ-defective 180BR cells. Our results indicate that high-LET radiation induces complex DNA damage that is not easily repaired or is not repaired by NHEJ even at low radiation doses such as 2 Gy...
  7. ncbi Recent advances in the biology of heavy-ion cancer therapy
    Nobuyuki Hamada
    Radiation Safety Research Center, Nuclear Technology Research Laboratory, Central Research Institute of Electric Power Industry, Komae, Tokyo, Japan
    J Radiat Res 51:365-83. 2010
    ..Immediately after irradiation, heavy ions produce dense ionization along their trajectories, cause irreparable clustered DNA damage, and alter cellular ..
  8. ncbi A murine model for bone loss from therapeutic and space-relevant sources of radiation
    S A Hamilton
    Dept of Bioengineering, Clemson University, Clemson, SC 29634, USA
    J Appl Physiol 101:789-93. 2006
    ..be exposed to extended periods of lower-dose radiation from multiple sources and of multiple types, including heavy ions. Therapeutic doses of radiation have been shown to have deleterious consequences on bone health, occasionally ..
  9. ncbi Treatment planning for the layer-stacking irradiation system for three-dimensional conformal heavy-ion radiotherapy
    Nobuyuki Kanematsu
    Department of Medical Physics, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba 263 8555, Japan
    Med Phys 29:2823-9. 2002
    ..The completed treatment system will provide an option for improved conformal radiotherapy without interfering with the conventional method and we expect a gradual expansion of the clinical cases applicable to the layer-stacking method...
  10. ncbi Heavy ion beam irradiation regulates the mRNA expression in megakaryocytopoiesis from human hematopoietic stem/progenitor cells
    Satoru Monzen
    Department of Radiological Life Sciences, Hirosaki University Graduate School of Health Sciences, Hirosaki, Japan
    J Radiat Res 50:477-86. 2009
    ..0-fold and a 21.8-fold increase at 6 hr in comparison to the initial control. These results showed that the heavy ion beams affect megakaryocytopoiesis/ erythropoiesis differentiation of human HSPCs on the gene expression level...
  11. ncbi Severe damage of human megakaryocytopoiesis and thrombopoiesis by heavy-ion beam radiation
    Kenji Takahashi
    Department of Bio information Radiation Sciences, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori 036 8564, Japan
    Radiat Res 168:545-51. 2007
    b>Heavy ions have a unique efficacy for tumor control in radiotherapy...
  12. doi Comparison of the effects of carbon ion and photon irradiation on the angiogenic response in human lung adenocarcinoma cells
    Florentine Kamlah
    Department of Radiotherapy and Radiooncology, Philipps University, Marburg, Germany
    Int J Radiat Oncol Biol Phys 80:1541-9. 2011
    ..In this study, we used human lung adenocarcinoma (A549) cells to compare the effects of carbon ion and X-ray irradiation on the cells' angiogenic response...
  13. ncbi High-LET radiation induces inflammation and persistent changes in markers of hippocampal neurogenesis
    Radoslaw Rola
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143, USA
    Radiat Res 164:556-60. 2005
    ..These results indicate that high-LET radiation has a significant and long-lasting effect on the neurogenic population in the hippocampus that involves cell loss and changes in the microenvironment...
  14. ncbi Energetic heavy ions accelerate differentiation in the descendants of irradiated normal human diploid fibroblasts
    Nobuyuki Hamada
    Department of Quantum Biology, Division of Bioregulatory Medicine, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Mutat Res 637:190-6. 2008
    ..Accelerated differentiation may account, at least in part, for dose- and LET-dependent delayed loss of clonogenicity in normal human diploid cells, and could be a defensive mechanism that minimizes further expansion of aberrant cells...
  15. doi How costly is particle therapy? Cost analysis of external beam radiotherapy with carbon-ions, protons and photons
    Andrea Peeters
    Maastricht Radiation Oncology MAASTRO Clinic, 6229 ET Maastricht, The Netherlands
    Radiother Oncol 95:45-53. 2010
    ..Particle therapy has potentially a better therapeutic ratio than photon therapy. However, investment costs are much higher. This study provides an estimation and comparison of the costs of these therapies...
  16. pmc Accelerated hematopoietic toxicity by high energy (56)Fe radiation
    Kamal Datta
    Department of Biochemistry and Molecular and Cell Biology and Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057 1468, USA
    Int J Radiat Biol 88:213-22. 2012
    ....
  17. ncbi Simultaneous exposure of mammalian cells to heavy ions and X-rays
    Y Furusawa
    National Institute of Radiological Sciences, Chiba, Japan
    Adv Space Res 30:877-84. 2002
    ..of mixed high-/low-LET radiation fields, mammalian cells were exposed in vitro simultaneously to X-rays and heavy ions, accelerated at the HIMAC accelerator. X-ray doses ranged from 1 to 11 Gy...
  18. ncbi Recent insights into the biological action of heavy-ion radiation
    Nobuyuki Hamada
    Department of Quantum Biology, Division of Bioregulatory Medicine, Gunma University Graduate School of Medicine, Gunma, Japan
    J Radiat Res 50:1-9. 2009
    ..During cancer therapy or long-term interplanetary manned explorations, humans are exposed to high-LET energetic heavy ions that inactivate cells more effectively than low-LET photons like X-rays and gamma-rays...
  19. pmc Transmissible and nontransmissible mutations induced by irradiating Arabidopsis thaliana pollen with gamma-rays and carbon ions
    Ken Naito
    Institute of Radiation Breeding, National Institute of Agrobiological Sciences, Ohmiya machi, Naka gun, Ibaraki 319 2293, Japan
    Genetics 169:881-9. 2005
    ....
  20. ncbi Heavy ions can enhance TGFβ mediated epithelial to mesenchymal transition
    Minli Wang
    USRA, Division of Life Sciences, Houston, TX 77058, USA
    J Radiat Res 53:51-7. 2012
    ..These studies indicate that heavy ions, even at a low dose, may trigger the process of TGFβ1-induced EMT, and suggest further studies are needed to ..
  21. ncbi Relative biological effectiveness for cell-killing effect on various human cell lines irradiated with heavy-ion medical accelerator in Chiba (HIMAC) carbon-ion beams
    M Suzuki
    International Space Radiation Laboratory, National Institute of Radiological Sciences, Anagawa, Japan
    Int J Radiat Oncol Biol Phys 48:241-50. 2000
    ....
  22. ncbi Effects of carbon-ion radiotherapy combined with a novel histone deacetylase inhibitor, cyclic hydroxamic-acid-containing peptide 31 in human esophageal squamous cell carcinoma
    Masayuki Kano
    Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chuoku, Chiba 260 0856, Japan
    Anticancer Res 29:4433-8. 2009
    ..Several studies have evaluated the combination of X-rays and HDACIs, but, to date, no study has evaluated carbon-ion radiotherapy combined with HDACIs...
  23. ncbi Sensitive detection of LOH events in a human cell line after C-ion beam exposure
    Shigeko Morimoto
    Division of Radioisotope Technology, The Institute of Physical and Chemical Research RIKEN, Saitama 351 0198, Japan
    J Radiat Res 43:S163-7. 2002
    ..In addition, an enhanced misrepair of C-ion-induced DSBs might also account for the induction of radiation-specific hemizygous-type LOH...
  24. ncbi Persistence of chromosome aberrations in mice acutely exposed to 56Fe+26 ions
    James D Tucker
    Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202 3917, USA
    Radiat Res 161:648-55. 2004
    ..The health effects of exposure to high-LET radiation in humans on prolonged space flights should remain a matter of concern...
  25. ncbi LET dependency of heavy-ion induced apoptosis in V79 cells
    M Aoki
    Space and Particle Radiation Science Research Group, National Institute of Radiological Sciences, Chiba, Japan
    J Radiat Res 41:163-75. 2000
    ..13, and 0.24, respectively. A similar trend was found for the RBE values calculated from the initial slope for both apoptosis and reproductive death. These results strongly suggest that the target for both types of cell death is the same...
  26. ncbi Clustered DNA damage induced by heavy ion particles
    Hiroaki Terato
    Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, Higashi Hiroshima, Japan
    Biol Sci Space 18:206-15. 2004
    ..In this article, we review methods used to detect clustered DNA damage, and the current status of our understanding of the chemical nature and repair of clustered DNA damage...
  27. ncbi Carbon beam therapy overcomes the radiation resistance of uterine cervical cancer originating from hypoxia
    Takashi Nakano
    Research Center Hospital of Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
    Clin Cancer Res 12:2185-90. 2006
    ..However, no proof of this effect has been provided by clinical trials and related clinical research. Hence, we investigated the radiation biological aspects of high LET carbon beam therapy on cervical cancer...
  28. doi Carbon-ion-induced activation of the NF-κB pathway
    Christine E Hellweg
    German Aerospace Centre DLR, Institute of Aerospace Medicine, Radiation Biology, Linder Hohe, D 51147 Köln, Germany
    Radiat Res 175:424-31. 2011
    ..Carbon ions and X rays had a comparable potential to activate NF-κB in human cells, indicating a comparable usefulness of pharmacological NF-κB inhibition during photon and carbon-ion radiotherapy...
  29. doi Gene expression analysis in human malignant melanoma cell lines exposed to carbon beams
    Yoshitaka Matsumoto
    Graduate School of Medicine, Chiba University, Chiba, Japan
    Int J Radiat Biol 84:299-314. 2008
    ..To elucidate the molecular changes in response to carbon beams (C-ions) in melanoma...
  30. ncbi Chlorophyll-deficient mutants of rice demonstrated the deletion of a DNA fragment by heavy-ion irradiation
    Tomoko Abe
    Plant Functions Lab RIKEN, Hirosawa, Wako Shi, Saitama 351 0198, Japan
    J Radiat Res 43:S157-61. 2002
    ..We found that one of the polymorphic spots was strongly linked to the albino phenotypic mutant derived from deleting of a DNA fragment, and demonstrated the high ability to detect of polymorphic regions by the RLGS method...
  31. ncbi Terminal maturation of megakaryocytes and platelet production by hematopoietic stem cells irradiated with heavy-ion beams
    Satoru Monzen
    Department of Radiological Life Sciences, Hirosaki University Graduate School of Health Sciences, 66 1 Hon cho, Hirosaki, Aomori 036 8564, Japan
    Radiat Res 176:8-16. 2011
    ....
  32. ncbi Design study of a raster scanning system for moving target irradiation in heavy-ion radiotherapy
    Takuji Furukawa
    Medical Physics Research Group, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba 263 8555, Japan
    Med Phys 34:1085-97. 2007
    ..The result shows the possibility of practical realization of moving target irradiation with pencil beam scanning. We describe the present status of our design study of the raster scanning system for the HIMAC new treatment facility...
  33. ncbi Early and delayed reproductive death in human cells exposed to high energy iron ion beams
    D Bettega
    Dipartimento di Fisica, Universita degli Studi di Milano and INFN Sezione di Milano, Milano, Italy
    Adv Space Res 35:280-5. 2005
    ..6 and 3 for early and delayed reproductive death, respectively. Analysis of the fluence-effect curves shows that the cross-sections for early and delayed inactivation increase with increasing LET up to 442 keV/micrometers...
  34. ncbi Exploration of "over kill effect" of high-LET Ar- and Fe-ions by evaluating the fraction of non-hit cell and interphase death
    Parinaz Mehnati
    Department of Medical Biophysics and Radiation Biology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Radiat Res 46:343-50. 2005
    ..These suggest that the increase in non-hit fraction and sigma[R] with an increasing LET is caused by enhanced clustering of ionization and DNA damage which lowers the energy efficiency for producing damage and RBE...
  35. ncbi Tissue slice cultures from humans or rodents: a new tool to evaluate biological effects of heavy ions
    Felicitas Merz
    Institute of Anatomy, University of Leipzig, Liebigstr 13, 04103 Leipzig, Germany
    Radiat Environ Biophys 49:457-62. 2010
    ..slice culture preparations from rodents and humans as a new model system for studying effects of X-rays and heavy ions within normal and tumor tissues...
  36. ncbi Effects of low-dose heavy ions on the postnatal development of mice and the yield of white spots in the mid-ventrum and tail-tips
    Tomohisa Hirobe
    Radiation Effect Mechanisms Research Group, Research Center for Radiation Protection, National Institute of Radiological Sciences, Chiba
    J Radiat Res 52:278-86. 2011
    Effects of prenatal low-dose irradiations of heavy ions on the postnatal development of mice and of melanocytes have not been well studied...
  37. doi X-ray-induced radioresistance against high-LET radiations from accelerated heavy ions in mice
    Bing Wang
    Research Center for Radiation Protection, National Institute of Radiological Sciences, Anagawa 4 9 1, Inage Ku, Chiba 263 8555, Japan
    Radiat Res 174:532-6. 2010
    ..of an adaptive response by priming X rays in combination with challenge irradiations from high-LET accelerated heavy ions was attempted in young adult female C57BL/6J Jms mice using 30-day survival after the challenge irradiations as ..
  38. ncbi Ascorbic acid gives different protective effects in human cells exposed to X-rays and heavy ions
    Yoshihiro Fujii
    Research Center for Charged Particle Therapy, Heavy Ion Radiobiology Research Group, National Institute of Radiological Sciences, Inage Ku, Chiba shi, Japan
    Mutat Res 699:58-61. 2010
    ..and sister chromatid exchanges (SCEs) were examined in normal human fibroblasts irradiated with X-rays and heavy ions. Post-irradiation treatment with 5mM ascorbic acid for 24 h in plateau phase (non-cycling) cells enhanced cell ..
  39. ncbi mFISH analysis of chromosomal damage in bone marrow cells collected from CBA/CaJ mice following whole body exposure to heavy ions (56Fe ions)
    K Noy Rithidech
    Pathology Department, Stony Brook University, Stony Brook, NY 11794 8691, USA
    Radiat Environ Biophys 46:137-45. 2007
    To date, there is scant information on in vivo induction of chromosomal damage by heavy ions found in space (i.e. 56Fe ions)...
  40. ncbi Truly incomplete and complex exchanges in prematurely condensed chromosomes of human fibroblasts exposed in vitro to energetic heavy ions
    Honglu Wu
    National Space Biomedical Research Institute, Baylor College of Medicine, NASA Johnson Space Center, Houston, Texas 77058, USA
    Radiat Res 160:418-24. 2003
    ..Results showed that the frequency of unrejoined chromosome breaks was higher after irradiation with the heavy ions of high LET, and consequently the ratio of incomplete to complete exchanges increased steadily with LET up to ..
  41. ncbi The analysis of the densely populated patterns of radiation-induced foci by a stochastic, Monte Carlo model of DNA double-strand breaks induction by heavy ions
    Artem L Ponomarev
    Universities Space Research Association USRA, Houston, TX, USA
    Int J Radiat Biol 86:507-15. 2010
    ..To resolve the difficulty in counting merged DNA damage foci in high-LET (linear energy transfer) ion-induced patterns...
  42. ncbi AT cells show dissimilar hypersensitivity to heavy-ion and X-rays irradiation
    Shoichiro Kitajima
    Central Laboratory and Radiation Biology, Aichi Cancer Center Research Institute, Nagoya 464 8681, Japan
    J Radiat Res 51:251-5. 2010
    ..The DSBs remaining after heavy-ion irradiation suggested defects in the AT cells' DSB repair ability...
  43. ncbi Dose escalation study of carbon ion radiotherapy for locally advanced head-and-neck cancer
    Jun etsu Mizoe
    Hospital, Research Center of Charged Particle, National Institute of Radiological Sciences, Chiba, Japan
    Int J Radiat Oncol Biol Phys 60:358-64. 2004
    ..To evaluate the toxicity and efficacy of carbon ion radiotherapy for head-and-neck cancer in a Phase I/II dose escalation clinical trial...
  44. ncbi Incidence of acute myeloid leukemia and hepatocellular carcinoma in mice irradiated with 1 GeV/nucleon (56)Fe ions
    Michael M Weil
    Department of Environmental and Radiological Health Sciences and, Colorado State University, Fort Collins, Colorado 80523, USA
    Radiat Res 172:213-9. 2009
    ..These data suggest a difference in the effects of HZE iron ions on the induction of leukemia compared to solid tumors, suggesting potentially different mechanisms of tumorigenesis...
  45. pmc Non-randomized therapy trial to determine the safety and efficacy of heavy ion radiotherapy in patients with non-resectable osteosarcoma
    Claudia Blattmann
    Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Im Neuenheimer Feld 154, 69120 Heidelberg, Germany
    BMC Cancer 10:96. 2010
    ..They achieve a higher relative biological effectiveness. Phase I/II dose escalation studies of HIT in adults with non-resectable bone and soft tissue sarcomas have already shown favorable results...
  46. ncbi Proliferation and cell death of human glioblastoma cells after carbon-ion beam exposure: morphologic and morphometric analyses
    Takuma Oishi
    Department of Human Pathology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Neuropathology 28:408-16. 2008
    ..Our results indicated that the increase of large cells with enlarged and bizarre nuclei, swollen mitochondria, and secondary lysosome occurred in glioblastoma cells after carbon-beam exposure...
  47. ncbi Heavy ions, radioprotectors and genomic instability: implications for human space exploration
    Jaroslaw Dziegielewski
    Department of Radiation Oncology, University of Virginia, Charlottesville, VA, USA
    Radiat Environ Biophys 49:303-16. 2010
    ..Further, this review discusses some implications of radioprotection for the induction and/or propagation of genomic instability in the progeny of irradiated cells...
  48. ncbi Microirradiation of cells with energetic heavy ions
    A Hauptner
    Physics Department E12, Technische Universitat Munchen, 85748 Garching, Germany
    Radiat Environ Biophys 42:237-45. 2004
    ..In spite of single ion irradiation, we frequently observed split fluorescence foci which might be explained by small-scale chromatin movements...
  49. ncbi The radiobiological effectiveness of carbon-ion beams on growing neurons
    Wael S Al-Jahdari
    Department of Radiation Oncology, Gunma University Graduate School of Medicine, Gunma, Japan
    Int J Radiat Biol 85:700-9. 2009
    ..However, the biological effect of carbon-ion beams arising on normal neuron remains unknown. Therefore, this study was undertaken to investigate the effect of carbon-ion beams on neurons by using both morphological and functional assays...
  50. ncbi Spectrum of complex DNA damages depends on the incident radiation
    Megumi Hada
    Biology Department, Brookhaven National Laboratory, Upton, New York 11973 5000, USA
    Radiat Res 165:223-30. 2006
    ..The relative frequencies of DSBs compared to abasic and oxybase clusters were higher for the charged particles-including the high-energy, low-LET protons-than for the ionizing photons...
  51. ncbi Cytotoxic effects of low- and high-LET radiation on human neuronal progenitor cells: induction of apoptosis and TP53 gene expression
    Peter Guida
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Radiat Res 164:545-51. 2005
    ..The RBE(max) for apoptosis 48 h after exposure was at least 3.4. In short, exposure to high-LET radiation results in a more efficient and greater induction of apoptosis in human neuronal progenitor cells than low-LET radiation...
  52. ncbi Molecular characterization of microbial mutations induced by ion beam irradiation
    Hiroyuki Ichida
    Graduate School of Science and Technology, Chiba University, Matsudo, Chiba 271 8510, Japan
    Mutat Res 639:101-7. 2008
    ..We found also that ion beams, particularly "heavier" ion beams, can produce single gene disruptions and may present an effective alternative to transgenic approaches...
  53. ncbi DNA damage recognition proteins localize along heavy ion induced tracks in the cell nucleus
    Akihisa Takahashi
    Department of Biology, School of Medicine, Nara Medical University, Nara, Japan
    J Radiat Res 49:645-52. 2008
    ..Antibodies for all these phosphorylated DNA DSB recognition proteins appear to be very effective for the detection and localization of DSB...
  54. ncbi In vitro interaction of high-LET heavy-ion irradiation and chemotherapeutic agents in two cell lines with different radiosensitivities and different p53 status
    Takeo Takahashi
    Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
    Anticancer Res 30:1961-7. 2010
    ....
  55. ncbi Chromatid-type aberrations following irradiation in G0 lymphocytes with heavy ions
    Wang Zhuanzi
    Radiobiology Laboratory, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, Gansu Province, China
    Mutat Res 617:98-103. 2007
    ..6 keV/microm), almost absent at the energy of either 58.6 MeV/n (46.07 keV/ microm) or 19.3 MeV/n (97 keV/microm), nor were they found after low-LET X-rays. Mechanisms potentially responsible for their formation are discussed...
  56. ncbi Clustered DNA damages induced by high and low LET radiation, including heavy ions
    B M Sutherland
    Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Phys Med 17:202-4. 2001
    ..e. two independent hits are not required for cluster induction. Further, among all complex damages, double strand breaks comprise--at most-- ~20%, with the other clustered damages being at least 80%...
  57. ncbi Heavy-ion-induced mutations in the gpt delta transgenic mouse: comparison of mutation spectra induced by heavy-ion, X-ray, and gamma-ray radiation
    Ken ichi Masumura
    Division of Genetics and Mutagenesis, National Institute of Health Sciences, Tokyo, Japan
    Environ Mol Mutagen 40:207-15. 2002
    ..These results suggest that heavy-ion beam irradiation is effective at inducing deletions via DNA double-strand breaks but less effective than X-ray and gamma-ray irradiation at producing oxidative DNA damage by free radicals...
  58. ncbi Estimation of radiation tolerance to high LET heavy ions in an anhydrobiotic insect, Polypedilum vanderplanki
    Masahiko Watanabe
    Anhydrobiosis Research Unit, National Institute of Agrobiological Sciences, Ohwashi, Tsukuba, Ibaraki, Japan
    Int J Radiat Biol 82:835-42. 2006
    ..2 keV/microm). However, its tolerance against high LET radiation remains unknown. The aim of this study is to characterize the tolerance to high-LET radiations of P. vanderplanki...
  59. ncbi A system for three-dimensional dosimetric verification of treatment plans in intensity-modulated radiotherapy with heavy ions
    C P Karger
    Deutsches Krebsforschungszentrum, Abteilung Medizinische Physik, Heidelberg, Germany
    Med Phys 26:2125-32. 1999
    ..The system allows efficient verification and documentation of carbon ion fields and is in principle also applicable to intensity-modulated photon beams...
  60. ncbi Temporally distinct response of irradiated normal human fibroblasts and their bystander cells to energetic heavy ions
    Nobuyuki Hamada
    Department of Quantum Biology, Division of Bioregulatory Medicine, Gunma University Graduate School of Medicine, Maebashi, Gunma 371 8511, Japan
    Mutat Res 639:35-44. 2008
    ..Collectively, our results indicate that heavy ions inactivate clonogenic potential of bystander cells, and that the time course of the response to heavy ions ..
  61. ncbi Outcomes of visual acuity in carbon ion radiotherapy: analysis of dose-volume histograms and prognostic factors
    Azusa Hasegawa
    Hospital, Charged Particle Research Center, National Institute of Radiological Sciences, Chiba, Japan
    Int J Radiat Oncol Biol Phys 64:396-401. 2006
    ..To analyze the tolerance dose for retention of visual acuity in patients with head-and-neck tumors treated with carbon ion radiotherapy...
  62. ncbi Protective effects of melatonin against low- and high-LET irradiation
    Guangming Zhou
    Radiobiology Group, Institute of Modern Physics, Chinese Academy of Sciences, China
    J Radiat Res 47:175-81. 2006
    ..The results suggest that melatonin reduces the direct interaction of particles with cells rather than an indirect interaction. Further studies are required to disclose the underlying mechanisms...
  63. ncbi Minor contribution of direct ionization to DNA base damage inducedby heavy ions
    Thierry Douki
    Laboratoire Lesions des Acides Nucleiques, Service de Chimie Inorganique et Biologique UMR E 3 CEA UJF, CEA DSM Département de Recherche Fondamentale sur la Matière Condensée, CEA Grenoble, Grenoble, France
    Int J Radiat Biol 82:119-27. 2006
    The deleterious processes triggered by heavy ions on DNA were studied through the determination of the yield of a series of oxidized bases...
  64. ncbi Ground-based research with heavy ions for space radiation protection
    M Durante
    Department of Physics, University Federico II, Monte S Angelo, Via Cintia, Naples, Italy
    Adv Space Res 35:180-4. 2005
    ..High quality accelerator-based research with heavy ions will continue to be the main source of knowledge of space radiation health effects and will lead to reductions ..
  65. ncbi LET and ion-species dependence for mutation induction and mutation spectrum on hprt locus in normal human fibroblasts
    Chizuru Tsuruoka
    International Space Radiation Laboratory, National Institute Radiological Sciences
    Biol Sci Space 18:188-9. 2004
    ..These results suggested that quantitative and qualitative difference in mutation occurred when using different ion species even if similar LET values...
  66. ncbi High LET-induced H2AX phosphorylation around the Bragg curve
    N Desai
    NASA Johnson Space Center, Houston, TX 77058, USA
    Adv Space Res 35:236-42. 2005
    ....
  67. ncbi Fragmentation studies of relativistic iron ions using plastic nuclear track detectors
    P Scampoli
    Department of Physics, University Federico II, and INFN, Sezione di Napoli, Monte S Angelo, Via Cintia, Napoli, Italy
    Adv Space Res 35:230-5. 2005
    ..These physical measurements will be used to characterize the beam used in parallel biological experiments...
  68. ncbi Fragmentation of 1 GeV/nucleon iron ions in thick targets relevant for space exploration
    C La Tessa
    Chalmers University of Technology, Nuclear Science and Engineering, Gothenburg, Sweden
    Adv Space Res 35:223-9. 2005
    ....
  69. ncbi Mutations induced by heavy charged particles
    Fumio Yatagai
    Advanced Development and Support Center, RIKEN Institute, Wako Shi, Saitama, Japan
    Biol Sci Space 18:224-34. 2004
    ..Finally, applications of mutation detection systems for studies in space (section 3) are described, in which the carcinogenic effects of space environmental radiation are considered...
  70. ncbi Microbeams of heavy charged particles
    Yasuhiko Kobayashi
    Research Group for Biotechnology Development, Japan Atomic Energy Research Institute JAERI Takasaki, Takasaki, Gunma, Japan
    Biol Sci Space 18:235-40. 2004
    ..These are the first studies in which single-ion direct hit effect and the bystander effect have been investigated using a high-LET heavy particle microbeam...
  71. ncbi Responses of a diamond detector to high-LET charged particles
    Makoto Sakama
    Tokyo Institute of Technology, 4259, Nagatsuta cho, Midori ku, Yokohama 226 8502, Japan
    Phys Med Biol 50:2275-89. 2005
    The responses of a commercial diamond detector (type 60003, PTW-Freiburg) to several heavy ions were examined...
  72. ncbi Instrumentation for investigation of the depth-dose distribution by the Liulin-5 instrument of a human phantom on the Russian segment of ISS for estimation of the radiation risk during long term space flights
    J Semkova
    Solar Terrestrial Influences Laboratory, Bulgarian Academy of Sciences, Sofia, Bulgaria
    Adv Space Res 34:1297-301. 2004
    ..Presented are the test results of the prototype unit. The spherical phantom will be flown on the ISS in 2004 year and Liulin-5 experiment is planned for 2005 year...
  73. ncbi Cellular parameters for track structure modeling of radiation hazard in space
    M P R Waligorski
    Center of Oncology, Krakow, Poland
    Adv Space Res 34:1378-82. 2004
    ..The "synergistic" effect of simultaneous charged particle transfers is accounted for by the "track overlap" mode inherent in the model of Katz...
  74. ncbi Simulations of an accelerator-based shielding experiment using the particle and heavy-ion transport code system PHITS
    T Sato
    JAERI, Tokai mura, Japan
    Adv Space Res 35:208-13. 2005
    ..for calculating total reaction cross sections, and addition of routines for calculating elastic scattering of heavy ions, and inclusion of radioactivity and burn up processes...
  75. ncbi DNA DSB induced by iron ions in human fibroblasts: LET dependence and shielding efficiency
    G Esposito
    Laboratorio di Fisica, Technology and Health Department, Istituto Superiore di Sanita, Rome, Italy
    Adv Space Res 35:243-8. 2005
    ..Protection is only observed at high iron ions energy, especially at 5 GeV/u, where PMMA shield gives higher protection compared to Al or Pb shields of the same thickness expressed in g/cm2...
  76. ncbi Mice heterozygous for the ATM gene are more sensitive to both X-ray and heavy ion exposure than are wildtypes
    B V Worgul
    Eye Radiation and Environmental Research Laboratory, Columbia University, New York, NY 10032, USA
    Adv Space Res 35:254-9. 2005
    ..The data show that heterozygosity for the ATM gene predisposes the eye to the cataractogenic influence of heavy ions and suggest that ATM heterozygotes in the human population may also be radiosensitive...
  77. doi COST-ENLIGHT strategic workshop on hadron (particle) therapy, CERN, Geneva, 3-4 May 2007
    R E Taylor
    Swansea University, South West Wales Cancer Centre, Singleton Hospital, Swansea, UK
    Br J Radiol 81:169-71. 2008
    ..This comprises a series of seven work packages, which will be a focus for European collaboration...
  78. doi Monitoring the irradiation field of 12C and 16O SOBP beams using positron emitters produced through projectile fragmentation reactions
    Taku Inaniwa
    Department of Energy Sciences, Tokyo Institute of Technology, 4259 Nagatsuta cho, Midori ku, Yokohama 226 8502, Japan
    Phys Med Biol 53:529-42. 2008
    In order to effectively utilize the prominent properties of heavy ions in radiotherapy, it is important to evaluate both the position of the field irradiated with incident ions and the absorbed dose distribution in a patient's body...
  79. ncbi High relative biologic effectiveness of carbon ion radiation on induction of rat mammary carcinoma and its lack of H-ras and Tp53 mutations
    Tatsuhiko Imaoka
    Experimental Radiobiology for Children s Health Research Group, Anagawa, Chiba, Japan
    Int J Radiat Oncol Biol Phys 69:194-203. 2007
    ..We undertook the present study to clarify the RBE of therapeutic carbon ion radiation and molecular changes that occur in the rat mammary cancer model...
  80. ncbi Doses and LET spectra in the beam of 12C with energy 500 MeV amu-1
    Iva Jadrnícková
    Department of Radiation Dosimetry, Nuclear Physics Institute AS CR, Na Truhlářce 39 64, 18086 Prague 8, Czech Republic
    Radiat Prot Dosimetry 122:488-90. 2006
    ..Data measured by means of a diamond detector and a spectrometer of linear energy transfer (LET) based on chemically etched track detectors are presented, analysed and discussed. LET spectra are also calculated by program SRIM...
  81. ncbi Experimental fragmentation studies with 12C therapy beams
    E Haettner
    Biophysik, Gesellschaft fur Schwerionenforschung, Planckstr 1, D 64291 Darmstadt, Germany
    Radiat Prot Dosimetry 122:485-7. 2006
    ..The preliminary results include energy- and angular distributions, fragment yields, build-up curves and attenuation of the primary carbon projectiles...
  82. ncbi Repair of skin damage during fractionated irradiation with gamma rays and low-LET carbon ions
    Koichi Ando
    Heavy Ion Radiobiology Research Group, National Institute of Radiological Sciences, Chiba, Japan
    J Radiat Res 47:167-74. 2006
    ....
  83. doi Mammalian cells loaded with platinum-containing molecules are sensitized to fast atomic ions
    N Usami
    Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization, Oho, Tsukuba, Japan
    Int J Radiat Biol 84:603-11. 2008
    ..The experiment consists in irradiating by fast ions cultured cells previously exposed to dichloroterpyridine Platinum (PtTC) and analyzing cell survival by a colony-forming assay...
  84. ncbi Confocal fluorescent imaging of tracks from heavy charged particles utilising new Al2O3:C,Mg crystals
    Mark S Akselrod
    Landauer, Inc, Stillwater Crystal Growth Division, 723 1 2 Eastgate Road, Stillwater, OK 74074, USA
    Radiat Prot Dosimetry 119:357-62. 2006
    ..Fast neutrons were detected using recoil protons produced in a polyethylene radiator installed in front of the crystalline detector. Three-dimensional reconstruction of a recoil proton propagating through the crystal was demonstrated...
  85. ncbi Overview of secondary neutron production relevant to shielding in space
    L Heilbronn
    MS 74 197, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Radiat Prot Dosimetry 116:140-3. 2005
    ..Stopping target yields and cross section measurements conducted at particle accelerators using heavy ions with energies > 100 MeV per nucleon are discussed.
  86. ncbi HETC radiation transport code development for cosmic ray shielding applications in space
    L W Townsend
    Department of Nuclear Engineering, University of Tennessee, Knoxville, TN 37996 2300, USA
    Radiat Prot Dosimetry 116:135-9. 2005
    ..missions, the Monte Carlo radiation transport code HETC is being extended to include transport of energetic heavy ions, such as are found in the galactic cosmic ray spectrum in space...
  87. ncbi Shielding and fragmentation studies
    C Zeitlin
    Lawrence Berkeley National Laboratory, MS74 197, Berkeley, CA 94720, USA
    Radiat Prot Dosimetry 116:123-4. 2005
    ..Measurement without a target present gives an indication of the level of contamination of the primary beam, which is also important in radiobiology experiments...
  88. ncbi Investigation of heavy-ion-induced sucrose radicals by electron paramagnetic resonance
    Kouichi Nakagawa
    RI Research Center, Fukushima Medical University, 1 Hikarigaoka, Fukushima, 960 1295, Japan
    Radiat Res 164:336-8. 2005
    ..In addition, the EPR response had a linear relationship with dose in the dose range of 5-60 Gy. Thus the present EPR results show that sucrose can be used to monitor the ionizing particle based on the radical yield...
  89. ncbi Tumor induction in mice locally irradiated with carbon ions: a retrospective analysis
    Koichi Ando
    Heavy Ion Radiobiology Research Group, National Institute of Radiological Sciences, Chiba, Japan
    J Radiat Res 46:185-90. 2005
    ..2 for tumor induction and 1.9 for early skin reaction. We conclude that risk of secondary tumor induction by carbon-ion radiotherapy would not be seriously higher than anticipated...
  90. ncbi Analysis of secondary electron emission spectra of equal-LET protons and alpha particles for purposes of radiation quality and spaceflight hazard assessment
    P A Craven
    Institute of Cancer Research, University of London, London, UK
    Adv Space Res 35:300-4. 2005
    ..Such a method for numerically assessing radiation quality may have implications for procedures for heavy ion protection in space at low doses and for understanding the initial mechanisms of radiation action...
  91. ncbi Chromosome aberration yields and apoptosis in human lymphocytes irradiated with Fe-ions of differing LET
    R Lee
    Biophysik, Gesellschaft fur Schwerionenforschung, Darmstadt, Germany
    Adv Space Res 35:268-75. 2005
    ..The significance of this observation for the estimation of the health risk associated with space radiation remains to be elucidated...
  92. doi Visualizing the dose distribution and linear energy transfer by 1D and 2D ESR imaging: a potassium dithionate dosimeter irradiated with C6+ and N7+ ions
    Hakan Gustafsson
    J Phys Chem B 112:8437-42. 2008
    ..and linear energy transfer (LET) in a potassium dithionate, K2S2O6 (PDT), dosimeter irradiated with the heavy ions C(6+) and N(7+)...
  93. ncbi The physical and radiobiological basis of the local effect model: a response to the commentary by R. Katz
    M Scholz
    GSI Biophysics, Darmstadt, Germany
    Radiat Res 161:612-20. 2004
    ..In contrast, e.g. for very heavy ions, there are significant discrepancies observed for the Katz approach...
  94. ncbi ESR investigation of sucrose radicals produced by particle irradiation
    Kouichi Nakagawa
    RI Research Center, Fukushima Medical University, 1 Hikarigaoka, Fukushima, 960 1295, Japan
    Spectrochim Acta A Mol Biomol Spectrosc 60:1315-8. 2004
    ..The impact of heavy ions on sucrose produced sucrose radicals, which were measured by ESR...
  95. ncbi Chromosome aberrations induced in human lymphocytes by heavy charged particles in track segment mode
    M Di Giorgio
    Autoridad Regulatoria Nuclear, Av del Libertador 8250, CP C1429BNP, Ciudad de Buenos Aires, Argentina
    Radiat Prot Dosimetry 108:47-53. 2004
    ..The existence or otherwise of a beta component of the dose-response at these radiation qualities has important consequences for modelling mechanisms of aberration induction by radiation...
  96. ncbi Cosmic ray measurements at aircraft altitudes and comparison with predictions of computer codes
    D Zhou
    Dublin Institute for Advanced Studies, Astrophysics Section, Dublin, Ireland
    Adv Space Res 32:47-52. 2003
    ..The detectors were calibrated using energetic heavy ions. Data obtained were compared with the predictions of the EPCARD and CARI-6 codes...
  97. ncbi Chromatin organization contributes to non-randomly distributed double-strand breaks after exposure to high-LET radiation
    Irina Radulescu
    Division of Biomedical Radiation Sciences, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
    Radiat Res 161:1-8. 2004
    ..However, our data suggest a complex interaction between track structure and chromatin organization over several levels...
  98. ncbi The response of a spherical tissue-equivalent proportional counter to different ions having similar linear energy transfer
    Stephen B Guetersloh
    Department of Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
    Radiat Res 161:64-71. 2004
    ..However, both values were within 15% of LET in all cases...
  99. ncbi Effects of low dose particle radiation to mouse neonatal neurons in culture
    Kumie Nojima
    International Space Radiation Laboratory, National Institute of Radiological Sciences NIRS, Inage, Chiba, Japan
    Biol Sci Space 17:263-4. 2003
    ..dose heavy particle radiation to CNS system, we adopted mouse neonatal brain cells in culture being exposed to heavy ions generated by HIMAC at NIRS and BNL. The applied dose varied from 0.05 Gy up to 2.0 Gy...
  100. ncbi LET and ion-species dependence for cell killing and mutation induction in normal human fibroblasts
    Chizuru Tsuruoka
    International Space Radiation Laboratory, National Institute Radiological Science
    Biol Sci Space 17:185-6. 2003
    ..These results suggested that different biological endpoints may be suitable for different physical parameter, which represent the track structure of energy deposition of ion beams...
  101. ncbi Conversion coefficients from fluence to effective dose for heavy ions with energies up to 3 GeV/A
    T Sato
    Japan Atomic Energy Research Institute, Shirakata Shirane 2 4, Tokai mura, Naka gun, Ibaraki, 319 1195, Japan
    Radiat Prot Dosimetry 106:137-44. 2003
    Radiological protection against high-energy heavy ions has been an essential issue in the planning of long-term space missions...

Research Grants74

  1. EFFECTS OF RADIATION ON MAMALIAN CELLS
    John Little; Fiscal Year: 1990
    ..the spectrum of molecular structural changes induced by different types of radiation including fast neutrons, heavy ions and Auger emitting radionuclides...
  2. HEAVY-ION MUTAGENESIS
    Amy Kronenberg; Fiscal Year: 1990
    Selected heavy ions have been shown to be potent inducers of mutations in human TK6 lymphoblasts at two distinct genetic loci: thymidine kinase (tk) and hypoxanthine phosphoribosyltransferase (hgprt)...
  3. HEAVY PARTICLES IN RADIOTHERAPY: A COMPARATIVE STUDY
    MUDUNDI RAJU; Fiscal Year: 1980
    ..Therapeutic applications of protons at Harvard, helium and heavy ions at Berkeley, and negative pions at Los Alamos are in progress...
  4. HEAVY ION RADIOBIOLOGY RELATED TO ONCOLOGY
    CORNELIUS TOBIAS; Fiscal Year: 1980
    ..The rationale for using heavy ions in therapy is based on (a) the physical characteristics of charged particle beams which can be used to deliver a ..
  5. DEVELOPMENTAL GENETICS WITH AN INDUCIBLE GENE SYSTEM
    Michael Freeling; Fiscal Year: 1980
    ..1) Mutants involved in regulatory components of the genes will be induced--especially using accelerated heavy ions, e.g...
  6. THE RESPONSE OF A RAT RHABDOMYOSARCOMA TO HEAVY IONS
    STANLEY CURTIS; Fiscal Year: 1980
    ....
  7. AGING, RADIATION & DNA DAMAGE IN NONDIVIDING TISSUE
    JOHN LETT; Fiscal Year: 1980
    ..Such studies are mutually complementary with experiments of the effects of heavy ions that are being conducted for NASA. 4...
  8. FRAGMENTATION OF HEAVY IONS FOR BIOMEDICAL RESEARCH
    PIYARE JAIN; Fiscal Year: 1980
    ..project will measure the physical parameters of importance for the therapeutical application of BEVALAC-produced heavy ions, such as (C,Ne,Ar)...
  9. AAPM CHARGED PARTICLE BEAM DOSIMETRY TASK GROUP
    Alfred Smith; Fiscal Year: 1980
    ..basic physics, dosimetry, and clinical problems in the treatment of cancer with charged particle beams (pions, heavy ions, and protons); to design and build a calorimeter for the absolute calibration of charged particle beams; and to ..
  10. GEV HEAVY-ION AND 200 KV X-RAY EXCITATION OF DNA
    Malcolm Daniels; Fiscal Year: 1980
    ..Excitation sources will be 200kV X-ray, GeV heavy ions, 60Co gamma-rays, and synchrotron radiation...
  11. Electron Transport in Tissue-Like Material
    LARRY TOBUREN; Fiscal Year: 2006
    ..The results will enhance our effort to establish clinically relevant radiation treatment with a better understanding of potential damage to healthy tissue. [unreadable] [unreadable] [unreadable]..
  12. Electron Transport in Tissue-Like Material
    LARRY TOBUREN; Fiscal Year: 2008
    ..The results will enhance our effort to establish clinically relevant radiation treatment with a better understanding of potential damage to healthy tissue. [unreadable] [unreadable] [unreadable]..
  13. Electron Transport in Tissue-Like Material
    LARRY TOBUREN; Fiscal Year: 2002
    ..abstract_text> ..
  14. Electron Transport in Tissue-Like Material
    LARRY TOBUREN; Fiscal Year: 2003
    ..abstract_text> ..
  15. Electron Transport in Tissue-Like Material
    LARRY TOBUREN; Fiscal Year: 2004
    ..abstract_text> ..
  16. Electron Transport in Tissue-Like Material
    LARRY TOBUREN; Fiscal Year: 2007
    ..The results will enhance our effort to establish clinically relevant radiation treatment with a better understanding of potential damage to healthy tissue. [unreadable] [unreadable] [unreadable]..
  17. HIGH LET RADIATION & GENOMIC INSTABILITY IN HUMAN CELLS
    Amy Kronenberg; Fiscal Year: 1999
    ..The results obtained with low fluence iron-ion exposures will serve as a model for terrestrial exposures to radon and neutrons. ..
  18. HIGH LET RADIATION & GENOMIC INSTABILITY IN HUMAN CELLS
    Amy Kronenberg; Fiscal Year: 2001
    ..The results obtained with low fluence iron-ion exposures will serve as a model for terrestrial exposures to radon and neutrons. ..
  19. HIGH LET RADIATION & GENOMIC INSTABILITY IN HUMAN CELLS
    Amy Kronenberg; Fiscal Year: 2000
    ..The results obtained with low fluence iron-ion exposures will serve as a model for terrestrial exposures to radon and neutrons. ..
  20. Prediction of Second Cancer Risks for Children Treated with Proton - vs. - Photon
    Wayne D Newhauser; Fiscal Year: 2010
    ..In the future, we expect that the lower-risk treatments will result in fewer second cancers and this will translate into longer, higher-quality lives for survivors of childhood cancer (presently 270,000 persons in the United States). ..
  21. Radiation-Induced Mutagenesis and Apoptotic Regulation
    Amy Kronenberg; Fiscal Year: 2006
    ..It is the secondary mutations that lead to advance, aggressive disease in people. ..
  22. RADIATION BIOLOGY TRAINING GRANT
    Ann Kennedy; Fiscal Year: 2007
    ..It is expected that graduates of the training program will continue with their research and academic careers in radiation biology and oncology. ..
  23. Chemotherapy with injectable microdroplets
    FRANCESCO D ERRICO; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  24. Magnetic Flow Sorter for Pancreatic Islet Isolation
    Paul Todd; Fiscal Year: 2008
    ....
  25. RADIATION BIOLOGY TRAINING GRANT
    Ann Kennedy; Fiscal Year: 2008
    ..It is expected that graduates of the training program will continue with their research and academic careers in radiation biology and oncology. ..
  26. Role of TGFBI gene in cell proliferation and tumor progression
    Yongliang Zhao; Fiscal Year: 2008
    ....
  27. Role of TGFBI gene in cell proliferation and tumor progression
    Yongliang Zhao; Fiscal Year: 2009
    ....
  28. Prediction of Second Cancer Risks for Children Treated with Proton - vs. - Photon
    Wayne Newhauser; Fiscal Year: 2009
    ..In the future, we expect that the lower-risk treatments will result in fewer second cancers and this will translate into longer, higher-quality lives for survivors of childhood cancer (presently 270,000 persons in the United States). ..
  29. Role of TGFBI gene in cell proliferation and tumor progression
    Yongliang Zhao; Fiscal Year: 2010
    ....
  30. Radiation-Induced Mutagenesis and Apoptotic Regulation
    Amy Kronenberg; Fiscal Year: 2005
    ..It is the secondary mutations that lead to advance, aggressive disease in people. ..
  31. Radiation-Induced Mutagenesis and Apoptotic Regulation
    Amy Kronenberg; Fiscal Year: 2004
    ..It is the secondary mutations that lead to advance, aggressive disease in people. ..
  32. Eighth International Workshop on Radiation Damage to DNA
    KATHRYN HELD; Fiscal Year: 2004
    ..abstract_text> ..
  33. HIGH ENERGY IONS AND GENOMIC INSTABILITY
    Eric Hall; Fiscal Year: 2000
    ....
  34. HIGH ENERGY IONS AND GENOMIC INSTABILITY
    Eric Hall; Fiscal Year: 2001
    ....
  35. MECHANISMS FOR OXIDATIVE STRESS INDUCED APOPTOSIS
    KATHRYN HELD; Fiscal Year: 1999
    ..g., to enhance cell killing in tumor cells or prevent cell killing in AIDS, autoimmune diseases, neurodegenerative diseases, etc., where oxidative stress may play a role. ..
  36. HIGH ENERGY IONS AND GENOMIC INSTABILITY
    Eric Hall; Fiscal Year: 1999
    ....
  37. Radiation-Induced Mutagenesis and Apoptotic Regulation
    Amy Kronenberg; Fiscal Year: 2003
    ..It is the secondary mutations that lead to advance, aggressive disease in people. ..
  38. ENHANCED APOPTOSIS BY TARGETING PROTEIN REDOX STATUS
    Mohan Natarajan; Fiscal Year: 2009
    ..abstract_text> ..
  39. ENHANCED APOPTOSIS BY TARGETING PROTEIN REDOX STATUS
    Mohan Natarajan; Fiscal Year: 2008
    ..abstract_text> ..
  40. ENHANCED APOPTOSIS BY TARGETING PROTEIN REDOX STATUS
    Mohan Natarajan; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  41. Magnetic Sorter Channels for Stem Cells
    Paul Todd; Fiscal Year: 2006
    ..abstract_text> ..
  42. ENHANCED APOPTOSIS BY TARGETING PROTEIN REDOX STATUS
    Mohan Natarajan; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  43. Magnetic Flow Sorter for Pancreatic Islet Isolation
    Paul Todd; Fiscal Year: 2005
    ..abstract_text> ..