heavy ions

Summary

Summary: Positively-charged atomic nuclei that have been stripped of their electrons. These particles have one or more units of electric charge and a mass exceeding that of the Helium-4 nucleus (alpha particle).

Top Publications

  1. ncbi Recent advances in the biology of heavy-ion cancer therapy
    Nobuyuki Hamada
    Radiation Safety Research Center, Nuclear Technology Research Laboratory, Central Research Institute of Electric Power Industry, Komae, Tokyo, Japan
    J Radiat Res 51:365-83. 2010
  2. ncbi Heavy ion carcinogenesis and human space exploration
    Marco Durante
    Biophysics group at GSI, Planckstrasse 1, 64291 Darmstadt, Germany
    Nat Rev Cancer 8:465-72. 2008
  3. ncbi Repair of DNA damage induced by accelerated heavy ions in mammalian cells proficient and deficient in the non-homologous end-joining pathway
    Ryuichi Okayasu
    International Space Radiation Laboratory, National Institute of Radiological Sciences, Inage Ku, Chiba shi 263 8555, Japan
    Radiat Res 165:59-67. 2006
  4. ncbi Heavy ion beam irradiation regulates the mRNA expression in megakaryocytopoiesis from human hematopoietic stem/progenitor cells
    Satoru Monzen
    Department of Radiological Life Sciences, Hirosaki University Graduate School of Health Sciences, Hirosaki, Japan
    J Radiat Res 50:477-86. 2009
  5. ncbi Spatiotemporal analysis of DNA repair using charged particle radiation
    F Tobias
    GSI Helmholtzzentrum fur Schwerionenforschung, Biophysik, Planckstrasse 1, D 64291 Darmstadt, Germany
    Mutat Res 704:54-60. 2010
  6. ncbi LET dependency of heavy-ion induced apoptosis in V79 cells
    M Aoki
    Space and Particle Radiation Science Research Group, National Institute of Radiological Sciences, Chiba, Japan
    J Radiat Res 41:163-75. 2000
  7. ncbi Change in radiosensitivity with fractionated-dose irradiation of carbon-ion beams in five different human cell lines
    M Suzuki
    International Space Radiation Laboratory, National Institute of Radiological Sciences, Chiba, Japan
    Int J Radiat Oncol Biol Phys 48:251-8. 2000
  8. ncbi Persistence of chromosome aberrations in mice acutely exposed to 56Fe+26 ions
    James D Tucker
    Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202 3917, USA
    Radiat Res 161:648-55. 2004
  9. ncbi Gene expression analysis in human malignant melanoma cell lines exposed to carbon beams
    Yoshitaka Matsumoto
    Graduate School of Medicine, Chiba University, Chiba, Japan
    Int J Radiat Biol 84:299-314. 2008
  10. pmc Accelerated hematopoietic toxicity by high energy (56)Fe radiation
    Kamal Datta
    Department of Biochemistry and Molecular and Cell Biology and Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057 1468, USA
    Int J Radiat Biol 88:213-22. 2012

Detail Information

Publications262 found, 100 shown here

  1. ncbi Recent advances in the biology of heavy-ion cancer therapy
    Nobuyuki Hamada
    Radiation Safety Research Center, Nuclear Technology Research Laboratory, Central Research Institute of Electric Power Industry, Komae, Tokyo, Japan
    J Radiat Res 51:365-83. 2010
    ..Immediately after irradiation, heavy ions produce dense ionization along their trajectories, cause irreparable clustered DNA damage, and alter cellular ..
  2. ncbi Heavy ion carcinogenesis and human space exploration
    Marco Durante
    Biophysics group at GSI, Planckstrasse 1, 64291 Darmstadt, Germany
    Nat Rev Cancer 8:465-72. 2008
    ..Here, we describe how research in cancer radiobiology can support human missions to Mars and other planets...
  3. ncbi Repair of DNA damage induced by accelerated heavy ions in mammalian cells proficient and deficient in the non-homologous end-joining pathway
    Ryuichi Okayasu
    International Space Radiation Laboratory, National Institute of Radiological Sciences, Inage Ku, Chiba shi 263 8555, Japan
    Radiat Res 165:59-67. 2006
    ..This delay was further emphasized in NHEJ-defective 180BR cells. Our results indicate that high-LET radiation induces complex DNA damage that is not easily repaired or is not repaired by NHEJ even at low radiation doses such as 2 Gy...
  4. ncbi Heavy ion beam irradiation regulates the mRNA expression in megakaryocytopoiesis from human hematopoietic stem/progenitor cells
    Satoru Monzen
    Department of Radiological Life Sciences, Hirosaki University Graduate School of Health Sciences, Hirosaki, Japan
    J Radiat Res 50:477-86. 2009
    ..0-fold and a 21.8-fold increase at 6 hr in comparison to the initial control. These results showed that the heavy ion beams affect megakaryocytopoiesis/ erythropoiesis differentiation of human HSPCs on the gene expression level...
  5. ncbi Spatiotemporal analysis of DNA repair using charged particle radiation
    F Tobias
    GSI Helmholtzzentrum fur Schwerionenforschung, Biophysik, Planckstrasse 1, D 64291 Darmstadt, Germany
    Mutat Res 704:54-60. 2010
    ..With the help of the microbeam, geometrical patterns of traversing ions can be applied facilitating the analysis of spatial organisation of repair...
  6. ncbi LET dependency of heavy-ion induced apoptosis in V79 cells
    M Aoki
    Space and Particle Radiation Science Research Group, National Institute of Radiological Sciences, Chiba, Japan
    J Radiat Res 41:163-75. 2000
    ..13, and 0.24, respectively. A similar trend was found for the RBE values calculated from the initial slope for both apoptosis and reproductive death. These results strongly suggest that the target for both types of cell death is the same...
  7. ncbi Change in radiosensitivity with fractionated-dose irradiation of carbon-ion beams in five different human cell lines
    M Suzuki
    International Space Radiation Laboratory, National Institute of Radiological Sciences, Chiba, Japan
    Int J Radiat Oncol Biol Phys 48:251-8. 2000
    ..To investigate the change in the surviving fractions by fractionated-dose irradiations with carbon ions, based on the recovery of potentially lethal damage (PLDR) and the change of radiosensitivity by every fractionated-dose irradiation...
  8. ncbi Persistence of chromosome aberrations in mice acutely exposed to 56Fe+26 ions
    James D Tucker
    Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202 3917, USA
    Radiat Res 161:648-55. 2004
    ..The health effects of exposure to high-LET radiation in humans on prolonged space flights should remain a matter of concern...
  9. ncbi Gene expression analysis in human malignant melanoma cell lines exposed to carbon beams
    Yoshitaka Matsumoto
    Graduate School of Medicine, Chiba University, Chiba, Japan
    Int J Radiat Biol 84:299-314. 2008
    ..To elucidate the molecular changes in response to carbon beams (C-ions) in melanoma...
  10. pmc Accelerated hematopoietic toxicity by high energy (56)Fe radiation
    Kamal Datta
    Department of Biochemistry and Molecular and Cell Biology and Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057 1468, USA
    Int J Radiat Biol 88:213-22. 2012
    ....
  11. ncbi Biophysical calculation of cell survival probabilities using amorphous track structure models for heavy-ion irradiation
    Yuki Kase
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba 263 8555, Japan
    Phys Med Biol 53:37-59. 2008
    ....
  12. ncbi Comparison of the effects of carbon ion and photon irradiation on the angiogenic response in human lung adenocarcinoma cells
    Florentine Kamlah
    Department of Radiotherapy and Radiooncology, Philipps University, Marburg, Germany
    Int J Radiat Oncol Biol Phys 80:1541-9. 2011
    ..In this study, we used human lung adenocarcinoma (A549) cells to compare the effects of carbon ion and X-ray irradiation on the cells' angiogenic response...
  13. ncbi Energetic heavy ions accelerate differentiation in the descendants of irradiated normal human diploid fibroblasts
    Nobuyuki Hamada
    Department of Quantum Biology, Division of Bioregulatory Medicine, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Mutat Res 637:190-6. 2008
    ..Accelerated differentiation may account, at least in part, for dose- and LET-dependent delayed loss of clonogenicity in normal human diploid cells, and could be a defensive mechanism that minimizes further expansion of aberrant cells...
  14. ncbi Proton vs carbon ion beams in the definitive radiation treatment of cancer patients
    Herman Suit
    Department of Radiation Oncology, Boston, MA, USA
    Radiother Oncol 95:3-22. 2010
    ..The principal differences are LET, low for (1)H and high for (12)C, and a narrower penumbra of (12)C beams. Were (12)C to yield a higher TCP for a defined NTCP than (1)H therapy, would LET, fractionation or penumbra width be the basis?..
  15. ncbi Contribution of indirect action to radiation-induced mammalian cell inactivation: dependence on photon energy and heavy-ion LET
    Atsushi Ito
    Course of Energy Engineering, Department of Applied Science, School of Engineering, Tokai University, Hiratsuka shi, Kanagawa 259 1292, Japan
    Radiat Res 165:703-12. 2006
    ..4 keV to 1.25 MeV and for heavy ions over the linear energy transfer (LET) range from 20 keV/microm to 440 keV/microm by applying competition ..
  16. pmc Whole mouse blood microRNA as biomarkers for exposure to γ-rays and (56)Fe ion
    Thomas Templin
    Center for Radiological Research, Columbia University Medical Center, New York, NY, USA
    Int J Radiat Biol 87:653-62. 2011
    ..This study investigates to what extent microRNA (miRNA) expression signatures in mouse peripheral blood can be used as biomarkers for exposures to radiation with low and high linear energy transfers...
  17. ncbi Biological imaging of heavy charged-particle tracks
    B Jakob
    Gesellschaft fur Schwerionenforschung, Biophysik, Planckstrasse 1, D 64291 Darmstadt, Germany
    Radiat Res 159:676-84. 2003
    ..The results suggest that additional factors like compaction or confined movement of chromatin are responsible for the observed clustering of proteins...
  18. ncbi Redox changes induced in hippocampal precursor cells by heavy ion irradiation
    C L Limoli
    Department of Radiation Oncology, University of California Irvine, Medical Sciences I, Room B 149, Irvine, CA 92697 2695, USA
    Radiat Environ Biophys 46:167-72. 2007
    ..Given the prevalence of heavy ions in space and the duration of interplanetary travel, these data suggest that astronauts are at risk for ..
  19. ncbi Carbon ion radiotherapy: clinical experiences at National Institute of Radiological Science (NIRS)
    Tohru Okada
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Inage, Chiba 263 8555, Japan
    J Radiat Res 51:355-64. 2010
    ..This means that carbon ion radiotherapy can offer treatment for larger numbers of patients than is possible with other modalities over the same time period...
  20. ncbi A murine model for bone loss from therapeutic and space-relevant sources of radiation
    S A Hamilton
    Dept of Bioengineering, Clemson University, Clemson, SC 29634, USA
    J Appl Physiol 101:789-93. 2006
    ..be exposed to extended periods of lower-dose radiation from multiple sources and of multiple types, including heavy ions. Therapeutic doses of radiation have been shown to have deleterious consequences on bone health, occasionally ..
  21. ncbi High LET heavy ion radiation induces lower numbers of initial chromosome breaks with minimal repair than low LET radiation in normal human cells
    Emiko Sekine
    Heavy Ion Radiobiology Research Group, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba shi 263 8555, Japan
    Mutat Res 652:95-101. 2008
    ..These results at the chromosome level substantiate and extend the notion that high LET radiation produces complex-type DNA double strand breaks (DSBs)...
  22. ncbi Upregulation of stress-response genes with cell cycle arrest induced by carbon ion irradiation in multiple murine tumors models
    Kaori Imadome
    RadGenomics Project, National Institute of Radiological Sciences, Inage, Chiba, Japan
    Cancer Biol Ther 7:208-17. 2008
    ..To elucidate the in vivo biological effects induced by carbon-ion irradiation using comprehensive expression analysis...
  23. ncbi Carbon beam therapy overcomes the radiation resistance of uterine cervical cancer originating from hypoxia
    Takashi Nakano
    Research Center Hospital of Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
    Clin Cancer Res 12:2185-90. 2006
    ..However, no proof of this effect has been provided by clinical trials and related clinical research. Hence, we investigated the radiation biological aspects of high LET carbon beam therapy on cervical cancer...
  24. ncbi Radiobiological evaluation and correlation with the local effect model (LEM) of carbon ion radiation therapy and temozolomide in glioblastoma cell lines
    Stephanie E Combs
    Department of Radiation Oncology, University of Heidelberg
    Int J Radiat Biol 85:126-37. 2009
    ..To investigate the cytotoxic effect of high linear-energy transfer (LET) carbon irradiation on glioblastoma cells lines in combination with temozolomide (TMZ)...
  25. ncbi Minor contribution of direct ionization to DNA base damage inducedby heavy ions
    Thierry Douki
    Laboratoire Lesions des Acides Nucleiques, Service de Chimie Inorganique et Biologique UMR E 3 CEA UJF, CEA DSM Département de Recherche Fondamentale sur la Matière Condensée, CEA Grenoble, Grenoble, France
    Int J Radiat Biol 82:119-27. 2006
    The deleterious processes triggered by heavy ions on DNA were studied through the determination of the yield of a series of oxidized bases...
  26. ncbi Relative biological effectiveness for cell-killing effect on various human cell lines irradiated with heavy-ion medical accelerator in Chiba (HIMAC) carbon-ion beams
    M Suzuki
    International Space Radiation Laboratory, National Institute of Radiological Sciences, Anagawa, Japan
    Int J Radiat Oncol Biol Phys 48:241-50. 2000
    ....
  27. ncbi Ground-based research with heavy ions for space radiation protection
    M Durante
    Department of Physics, University Federico II, Monte S Angelo, Via Cintia, Naples, Italy
    Adv Space Res 35:180-4. 2005
    ..High quality accelerator-based research with heavy ions will continue to be the main source of knowledge of space radiation health effects and will lead to reductions ..
  28. ncbi Induction of DNA DSB and its rejoining in clamped and non-clamped tumours after exposure to carbon ion beams in comparison to X rays
    R Hirayama
    Heavy Ion Radiobiology Research Group, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba 263 8555, Japan
    Radiat Prot Dosimetry 143:508-12. 2011
    ..The yields of DSB in vivo depend on exposure doses, oxygen conditions and rejoining time, but not on the types of radiation quality...
  29. ncbi Mutagenic effects of carbon ions near the range end in plants
    Yoshihiro Hase
    Japan Atomic Energy Agency, Takasaki, Gunma, Japan
    Mutat Res 731:41-7. 2012
    To gain insight into the mutagenic effects of accelerated heavy ions in plants, the mutagenic effects of carbon ions near the range end (mean linear energy transfer (LET): 425keV/μm) were compared with the effects of carbon ions ..
  30. ncbi Mutations induced by heavy charged particles
    Fumio Yatagai
    Advanced Development and Support Center, RIKEN Institute, Wako Shi, Saitama, Japan
    Biol Sci Space 18:224-34. 2004
    ..Finally, applications of mutation detection systems for studies in space (section 3) are described, in which the carcinogenic effects of space environmental radiation are considered...
  31. ncbi Severe damage of human megakaryocytopoiesis and thrombopoiesis by heavy-ion beam radiation
    Kenji Takahashi
    Department of Bio information Radiation Sciences, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori 036 8564, Japan
    Radiat Res 168:545-51. 2007
    b>Heavy ions have a unique efficacy for tumor control in radiotherapy...
  32. ncbi Treatment planning for the layer-stacking irradiation system for three-dimensional conformal heavy-ion radiotherapy
    Nobuyuki Kanematsu
    Department of Medical Physics, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba 263 8555, Japan
    Med Phys 29:2823-9. 2002
    ..The completed treatment system will provide an option for improved conformal radiotherapy without interfering with the conventional method and we expect a gradual expansion of the clinical cases applicable to the layer-stacking method...
  33. ncbi Recent insights into the biological action of heavy-ion radiation
    Nobuyuki Hamada
    Department of Quantum Biology, Division of Bioregulatory Medicine, Gunma University Graduate School of Medicine, Gunma, Japan
    J Radiat Res 50:1-9. 2009
    ..During cancer therapy or long-term interplanetary manned explorations, humans are exposed to high-LET energetic heavy ions that inactivate cells more effectively than low-LET photons like X-rays and gamma-rays...
  34. pmc Transmissible and nontransmissible mutations induced by irradiating Arabidopsis thaliana pollen with gamma-rays and carbon ions
    Ken Naito
    Institute of Radiation Breeding, National Institute of Agrobiological Sciences, Ohmiya machi, Naka gun, Ibaraki 319 2293, Japan
    Genetics 169:881-9. 2005
    ....
  35. ncbi High-LET radiation induces inflammation and persistent changes in markers of hippocampal neurogenesis
    Radoslaw Rola
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143, USA
    Radiat Res 164:556-60. 2005
    ..These results indicate that high-LET radiation has a significant and long-lasting effect on the neurogenic population in the hippocampus that involves cell loss and changes in the microenvironment...
  36. ncbi Examination of GyE system for HIMAC carbon therapy
    Tatsuaki Kanai
    Department of Medical Physics, National Institute of Radiological Sciences, Chiba, Japan
    Int J Radiat Oncol Biol Phys 64:650-6. 2006
    ....
  37. ncbi Spectrum of complex DNA damages depends on the incident radiation
    Megumi Hada
    Biology Department, Brookhaven National Laboratory, Upton, New York 11973 5000, USA
    Radiat Res 165:223-30. 2006
    ..The relative frequencies of DSBs compared to abasic and oxybase clusters were higher for the charged particles-including the high-energy, low-LET protons-than for the ionizing photons...
  38. ncbi Effectiveness of monoenergetic and spread-out bragg peak carbon-ions for inactivation of various normal and tumour human cell lines
    Mauro Belli
    Istituto Superiore di Sanità and INFN Sezione di Roma1 Gruppo Collegato di Sanità, Roma, Italy
    J Radiat Res 49:597-607. 2008
    ....
  39. ncbi Effects of carbon-ion radiotherapy combined with a novel histone deacetylase inhibitor, cyclic hydroxamic-acid-containing peptide 31 in human esophageal squamous cell carcinoma
    Masayuki Kano
    Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chuoku, Chiba 260 0856, Japan
    Anticancer Res 29:4433-8. 2009
    ..Several studies have evaluated the combination of X-rays and HDACIs, but, to date, no study has evaluated carbon-ion radiotherapy combined with HDACIs...
  40. ncbi Biological effects of space radiation on human cells: history, advances and outcomes
    Mira Maalouf
    Institut National de la Sante et de la Recherche Medicale, U836, groupe de radiobiologie, Paris, France
    J Radiat Res 52:126-46. 2011
    ..efforts, the cancer and the toxicity risks remain to be quantified: 1) the nature and the frequency of secondary heavy ions need to be better characterized in order to estimate their contribution to the dose and to the final biological ..
  41. ncbi Simultaneous exposure of mammalian cells to heavy ions and X-rays
    Y Furusawa
    National Institute of Radiological Sciences, Chiba, Japan
    Adv Space Res 30:877-84. 2002
    ..of mixed high-/low-LET radiation fields, mammalian cells were exposed in vitro simultaneously to X-rays and heavy ions, accelerated at the HIMAC accelerator. X-ray doses ranged from 1 to 11 Gy...
  42. ncbi Gene expression profiling of breast cells induced by X-rays and heavy ions
    D Roy
    Department of Natural Sciences, Hostos College of the City University of New York, Bronx, NY 10541, USA
    Int J Mol Med 21:627-36. 2008
    ..This cell line was exposed to 10, 50, 100 and 200 cGy of either X-rays or heavy ions and gene expression profiles were studied...
  43. ncbi Heavy ions can enhance TGFβ mediated epithelial to mesenchymal transition
    Minli Wang
    USRA, Division of Life Sciences, Houston, TX 77058, USA
    J Radiat Res 53:51-7. 2012
    ..These studies indicate that heavy ions, even at a low dose, may trigger the process of TGFβ1-induced EMT, and suggest further studies are needed to ..
  44. ncbi Repair of skin damage during fractionated irradiation with gamma rays and low-LET carbon ions
    Koichi Ando
    Heavy Ion Radiobiology Research Group, National Institute of Radiological Sciences, Chiba, Japan
    J Radiat Res 47:167-74. 2006
    ....
  45. ncbi Comparison of cellular lethality in DNA repair-proficient or -deficient cell lines resulting from exposure to 70 MeV/n protons or 290 MeV/n carbon ions
    Stefan C Genet
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Oncol Rep 28:1591-6. 2012
    ..Genetic characterization of patient tumors would be key to individualize and optimize the selection of radiation modality, clinical outcome and treatment cost...
  46. ncbi How costly is particle therapy? Cost analysis of external beam radiotherapy with carbon-ions, protons and photons
    Andrea Peeters
    Maastricht Radiation Oncology MAASTRO Clinic, 6229 ET Maastricht, The Netherlands
    Radiother Oncol 95:45-53. 2010
    ..Particle therapy has potentially a better therapeutic ratio than photon therapy. However, investment costs are much higher. This study provides an estimation and comparison of the costs of these therapies...
  47. ncbi Tumor cell migration is not influenced by p21 in colon carcinoma cell lines after irradiation with X-ray or (12)C heavy ions
    Kristina Goetze
    Institute of Physiology and Pathophysiology, University Medical Centre of the Johannes Gutenberg University Mainz, Duesbergweg 6, 55128 Mainz, Germany
    Radiat Environ Biophys 49:427-35. 2010
    ..radiation treatment and even more for the cellular and molecular effects of therapeutically relevant (12)C heavy ions. The present study is therefore focused on the investigation of tumor cell migration in vitro after irradiation ..
  48. ncbi Recent innovations in carbon-ion radiotherapy
    Shinichi Minohara
    Department of Accelerator and Medical Physics, Research Center for Particle Therapy, National Institute of Radiological Sciences, Inage, Chiba, Japan
    J Radiat Res 51:385-92. 2010
    ..A great advantage of the active beam shaping method is patient-specific collimator-less and compensator-less treatment. This may be an interesting potential for adaptive radiotherapy...
  49. pmc Reduced contribution of thermally labile sugar lesions to DNA double strand break formation after exposure to heavy ions
    Satyendra K Singh
    Institute of Medical Radiation Biology, University of Duisburg Essen Medical School, Hufelandstr 55, Essen, 45122, Germany
    Radiat Oncol 8:77. 2013
    ..The consequences of these effects to the relative biological effectiveness are discussed...
  50. ncbi LET dependence of lethality of carbon ion irradiation to single tobacco cells
    Y Yokota
    Laboratory of Plant Breeding Science, Graduate School of Agriculture, Kyoto Prefectural University, Hangi machi 1 5, Shimogamo, Sakyo ku, Kyoto 606 8522 Japan
    Int J Radiat Biol 79:681-5. 2003
    To determine the radiation sensitivity and relationship between linear energy transfer (LET) and relative biological effectiveness (RBE) in single plant cells irradiated with heavy ions.
  51. pmc Chromosome damage in human cells by γ rays, α particles and heavy ions: track interactions in basic dose-response relationships
    Bradford D Loucas
    Department of Radiation Oncology, The University of Texas Medical Branch, Galveston, Texas 77555, USA
    Radiat Res 179:9-20. 2013
    ..While such track interaction had been previously theorized, to the best of our knowledge, it has never been demonstrated experimentally...
  52. ncbi Biological dose calculation with Monte Carlo physics simulation for heavy-ion radiotherapy
    Yuki Kase
    Department of Accelerator and Medical Physics, National Institute of Radiological Sciences, Chiba 263 8555, Japan
    Phys Med Biol 51:N467-75. 2006
    ..This study demonstrates that the Monte Carlo physics simulation technique can be applied to improve the accuracy of the biological dose distribution in treatment planning of heavy-ion radiotherapy...
  53. ncbi LET dependence of lethality in Arabidopsis thaliana irradiated by heavy ions
    Naoya Shikazono
    Department of Radiation Research for Environment and Resources, Takasaki Radiation Chemistry Research Establishment, Japan Atomic Energy Research Institute JAERI, Takasaki, Gunma, 370 1292, Japan
    Radiat Environ Biophys 41:159-62. 2002
    To clarify the effect of heavy ions in plants, dry seeds of Arabidopsis were irradiated with carbon, neon, and argon ions with various linear energy transfer (LET) values...
  54. ncbi Sensitive detection of LOH events in a human cell line after C-ion beam exposure
    Shigeko Morimoto
    Division of Radioisotope Technology, The Institute of Physical and Chemical Research RIKEN, Saitama 351 0198, Japan
    J Radiat Res 43:S163-7. 2002
    ..In addition, an enhanced misrepair of C-ion-induced DSBs might also account for the induction of radiation-specific hemizygous-type LOH...
  55. ncbi Clustered DNA damage induced by heavy ion particles
    Hiroaki Terato
    Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, Higashi Hiroshima, Japan
    Biol Sci Space 18:206-15. 2004
    ..In this article, we review methods used to detect clustered DNA damage, and the current status of our understanding of the chemical nature and repair of clustered DNA damage...
  56. ncbi Design study of a raster scanning system for moving target irradiation in heavy-ion radiotherapy
    Takuji Furukawa
    Medical Physics Research Group, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba 263 8555, Japan
    Med Phys 34:1085-97. 2007
    ..The result shows the possibility of practical realization of moving target irradiation with pencil beam scanning. We describe the present status of our design study of the raster scanning system for the HIMAC new treatment facility...
  57. ncbi Chlorophyll-deficient mutants of rice demonstrated the deletion of a DNA fragment by heavy-ion irradiation
    Tomoko Abe
    Plant Functions Lab RIKEN, Hirosawa, Wako Shi, Saitama 351 0198, Japan
    J Radiat Res 43:S157-61. 2002
    ..We found that one of the polymorphic spots was strongly linked to the albino phenotypic mutant derived from deleting of a DNA fragment, and demonstrated the high ability to detect of polymorphic regions by the RLGS method...
  58. ncbi Early and delayed reproductive death in human cells exposed to high energy iron ion beams
    D Bettega
    Dipartimento di Fisica, Universita degli Studi di Milano and INFN Sezione di Milano, Milano, Italy
    Adv Space Res 35:280-5. 2005
    ..6 and 3 for early and delayed reproductive death, respectively. Analysis of the fluence-effect curves shows that the cross-sections for early and delayed inactivation increase with increasing LET up to 442 keV/micrometers...
  59. ncbi Carbon-ion-induced activation of the NF-κB pathway
    Christine E Hellweg
    German Aerospace Centre DLR, Institute of Aerospace Medicine, Radiation Biology, Linder Hohe, D 51147 Köln, Germany
    Radiat Res 175:424-31. 2011
    ..Carbon ions and X rays had a comparable potential to activate NF-κB in human cells, indicating a comparable usefulness of pharmacological NF-κB inhibition during photon and carbon-ion radiotherapy...
  60. ncbi Terminal maturation of megakaryocytes and platelet production by hematopoietic stem cells irradiated with heavy-ion beams
    Satoru Monzen
    Department of Radiological Life Sciences, Hirosaki University Graduate School of Health Sciences, 66 1 Hon cho, Hirosaki, Aomori 036 8564, Japan
    Radiat Res 176:8-16. 2011
    ....
  61. ncbi Exploration of "over kill effect" of high-LET Ar- and Fe-ions by evaluating the fraction of non-hit cell and interphase death
    Parinaz Mehnati
    Department of Medical Biophysics and Radiation Biology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Radiat Res 46:343-50. 2005
    ..These suggest that the increase in non-hit fraction and sigma[R] with an increasing LET is caused by enhanced clustering of ionization and DNA damage which lowers the energy efficiency for producing damage and RBE...
  62. ncbi Truly incomplete and complex exchanges in prematurely condensed chromosomes of human fibroblasts exposed in vitro to energetic heavy ions
    Honglu Wu
    National Space Biomedical Research Institute, Baylor College of Medicine, NASA Johnson Space Center, Houston, Texas 77058, USA
    Radiat Res 160:418-24. 2003
    ..Results showed that the frequency of unrejoined chromosome breaks was higher after irradiation with the heavy ions of high LET, and consequently the ratio of incomplete to complete exchanges increased steadily with LET up to ..
  63. ncbi mFISH analysis of chromosomal damage in bone marrow cells collected from CBA/CaJ mice following whole body exposure to heavy ions (56Fe ions)
    K Noy Rithidech
    Pathology Department, Stony Brook University, Stony Brook, NY 11794 8691, USA
    Radiat Environ Biophys 46:137-45. 2007
    To date, there is scant information on in vivo induction of chromosomal damage by heavy ions found in space (i.e. 56Fe ions)...
  64. ncbi The analysis of the densely populated patterns of radiation-induced foci by a stochastic, Monte Carlo model of DNA double-strand breaks induction by heavy ions
    Artem L Ponomarev
    Universities Space Research Association USRA, Houston, TX, USA
    Int J Radiat Biol 86:507-15. 2010
    ..To resolve the difficulty in counting merged DNA damage foci in high-LET (linear energy transfer) ion-induced patterns...
  65. ncbi Ascorbic acid gives different protective effects in human cells exposed to X-rays and heavy ions
    Yoshihiro Fujii
    Research Center for Charged Particle Therapy, Heavy Ion Radiobiology Research Group, National Institute of Radiological Sciences, Inage Ku, Chiba shi, Japan
    Mutat Res 699:58-61. 2010
    ..and sister chromatid exchanges (SCEs) were examined in normal human fibroblasts irradiated with X-rays and heavy ions. Post-irradiation treatment with 5mM ascorbic acid for 24 h in plateau phase (non-cycling) cells enhanced cell ..
  66. ncbi X-ray-induced radioresistance against high-LET radiations from accelerated heavy ions in mice
    Bing Wang
    Research Center for Radiation Protection, National Institute of Radiological Sciences, Anagawa 4 9 1, Inage Ku, Chiba 263 8555, Japan
    Radiat Res 174:532-6. 2010
    ..of an adaptive response by priming X rays in combination with challenge irradiations from high-LET accelerated heavy ions was attempted in young adult female C57BL/6J Jms mice using 30-day survival after the challenge irradiations as ..
  67. ncbi Tissue slice cultures from humans or rodents: a new tool to evaluate biological effects of heavy ions
    Felicitas Merz
    Institute of Anatomy, University of Leipzig, Liebigstr 13, 04103 Leipzig, Germany
    Radiat Environ Biophys 49:457-62. 2010
    ..slice culture preparations from rodents and humans as a new model system for studying effects of X-rays and heavy ions within normal and tumor tissues...
  68. ncbi Effects of low-dose heavy ions on the postnatal development of mice and the yield of white spots in the mid-ventrum and tail-tips
    Tomohisa Hirobe
    Radiation Effect Mechanisms Research Group, Research Center for Radiation Protection, National Institute of Radiological Sciences, Chiba
    J Radiat Res 52:278-86. 2011
    Effects of prenatal low-dose irradiations of heavy ions on the postnatal development of mice and of melanocytes have not been well studied...
  69. ncbi AT cells show dissimilar hypersensitivity to heavy-ion and X-rays irradiation
    Shoichiro Kitajima
    Central Laboratory and Radiation Biology, Aichi Cancer Center Research Institute, Nagoya 464 8681, Japan
    J Radiat Res 51:251-5. 2010
    ..The DSBs remaining after heavy-ion irradiation suggested defects in the AT cells' DSB repair ability...
  70. ncbi Dose escalation study of carbon ion radiotherapy for locally advanced head-and-neck cancer
    Jun etsu Mizoe
    Hospital, Research Center of Charged Particle, National Institute of Radiological Sciences, Chiba, Japan
    Int J Radiat Oncol Biol Phys 60:358-64. 2004
    ..To evaluate the toxicity and efficacy of carbon ion radiotherapy for head-and-neck cancer in a Phase I/II dose escalation clinical trial...
  71. ncbi Incidence of acute myeloid leukemia and hepatocellular carcinoma in mice irradiated with 1 GeV/nucleon (56)Fe ions
    Michael M Weil
    Department of Environmental and Radiological Health Sciences and, Colorado State University, Fort Collins, Colorado 80523, USA
    Radiat Res 172:213-9. 2009
    ..These data suggest a difference in the effects of HZE iron ions on the induction of leukemia compared to solid tumors, suggesting potentially different mechanisms of tumorigenesis...
  72. ncbi Proliferation and cell death of human glioblastoma cells after carbon-ion beam exposure: morphologic and morphometric analyses
    Takuma Oishi
    Department of Human Pathology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Neuropathology 28:408-16. 2008
    ..Our results indicated that the increase of large cells with enlarged and bizarre nuclei, swollen mitochondria, and secondary lysosome occurred in glioblastoma cells after carbon-beam exposure...
  73. ncbi Heavy ions, radioprotectors and genomic instability: implications for human space exploration
    Jaroslaw Dziegielewski
    Department of Radiation Oncology, University of Virginia, Charlottesville, VA, USA
    Radiat Environ Biophys 49:303-16. 2010
    ..Further, this review discusses some implications of radioprotection for the induction and/or propagation of genomic instability in the progeny of irradiated cells...
  74. ncbi The radiobiological effectiveness of carbon-ion beams on growing neurons
    Wael S Al-Jahdari
    Department of Radiation Oncology, Gunma University Graduate School of Medicine, Gunma, Japan
    Int J Radiat Biol 85:700-9. 2009
    ..However, the biological effect of carbon-ion beams arising on normal neuron remains unknown. Therefore, this study was undertaken to investigate the effect of carbon-ion beams on neurons by using both morphological and functional assays...
  75. ncbi Microirradiation of cells with energetic heavy ions
    A Hauptner
    Physics Department E12, Technische Universitat Munchen, 85748 Garching, Germany
    Radiat Environ Biophys 42:237-45. 2004
    ..In spite of single ion irradiation, we frequently observed split fluorescence foci which might be explained by small-scale chromatin movements...
  76. ncbi Cytotoxic effects of low- and high-LET radiation on human neuronal progenitor cells: induction of apoptosis and TP53 gene expression
    Peter Guida
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Radiat Res 164:545-51. 2005
    ..The RBE(max) for apoptosis 48 h after exposure was at least 3.4. In short, exposure to high-LET radiation results in a more efficient and greater induction of apoptosis in human neuronal progenitor cells than low-LET radiation...
  77. pmc Non-randomized therapy trial to determine the safety and efficacy of heavy ion radiotherapy in patients with non-resectable osteosarcoma
    Claudia Blattmann
    Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Im Neuenheimer Feld 154, 69120 Heidelberg, Germany
    BMC Cancer 10:96. 2010
    ..They achieve a higher relative biological effectiveness. Phase I/II dose escalation studies of HIT in adults with non-resectable bone and soft tissue sarcomas have already shown favorable results...
  78. ncbi In vitro interaction of high-LET heavy-ion irradiation and chemotherapeutic agents in two cell lines with different radiosensitivities and different p53 status
    Takeo Takahashi
    Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
    Anticancer Res 30:1961-7. 2010
    ....
  79. ncbi Clustered DNA damages induced by high and low LET radiation, including heavy ions
    B M Sutherland
    Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Phys Med 17:202-4. 2001
    ..e. two independent hits are not required for cluster induction. Further, among all complex damages, double strand breaks comprise--at most-- ~20%, with the other clustered damages being at least 80%...
  80. ncbi Molecular characterization of microbial mutations induced by ion beam irradiation
    Hiroyuki Ichida
    Graduate School of Science and Technology, Chiba University, Matsudo, Chiba 271 8510, Japan
    Mutat Res 639:101-7. 2008
    ..We found also that ion beams, particularly "heavier" ion beams, can produce single gene disruptions and may present an effective alternative to transgenic approaches...
  81. ncbi Heavy-ion-induced mutations in the gpt delta transgenic mouse: comparison of mutation spectra induced by heavy-ion, X-ray, and gamma-ray radiation
    Ken ichi Masumura
    Division of Genetics and Mutagenesis, National Institute of Health Sciences, Tokyo, Japan
    Environ Mol Mutagen 40:207-15. 2002
    ..These results suggest that heavy-ion beam irradiation is effective at inducing deletions via DNA double-strand breaks but less effective than X-ray and gamma-ray irradiation at producing oxidative DNA damage by free radicals...
  82. ncbi DNA damage recognition proteins localize along heavy ion induced tracks in the cell nucleus
    Akihisa Takahashi
    Department of Biology, School of Medicine, Nara Medical University, Nara, Japan
    J Radiat Res 49:645-52. 2008
    ..Antibodies for all these phosphorylated DNA DSB recognition proteins appear to be very effective for the detection and localization of DSB...
  83. ncbi Chromatid-type aberrations following irradiation in G0 lymphocytes with heavy ions
    Wang Zhuanzi
    Radiobiology Laboratory, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, Gansu Province, China
    Mutat Res 617:98-103. 2007
    ..6 keV/microm), almost absent at the energy of either 58.6 MeV/n (46.07 keV/ microm) or 19.3 MeV/n (97 keV/microm), nor were they found after low-LET X-rays. Mechanisms potentially responsible for their formation are discussed...
  84. ncbi Temporally distinct response of irradiated normal human fibroblasts and their bystander cells to energetic heavy ions
    Nobuyuki Hamada
    Department of Quantum Biology, Division of Bioregulatory Medicine, Gunma University Graduate School of Medicine, Maebashi, Gunma 371 8511, Japan
    Mutat Res 639:35-44. 2008
    ..Collectively, our results indicate that heavy ions inactivate clonogenic potential of bystander cells, and that the time course of the response to heavy ions ..
  85. ncbi Outcomes of visual acuity in carbon ion radiotherapy: analysis of dose-volume histograms and prognostic factors
    Azusa Hasegawa
    Hospital, Charged Particle Research Center, National Institute of Radiological Sciences, Chiba, Japan
    Int J Radiat Oncol Biol Phys 64:396-401. 2006
    ..To analyze the tolerance dose for retention of visual acuity in patients with head-and-neck tumors treated with carbon ion radiotherapy...
  86. ncbi Estimation of radiation tolerance to high LET heavy ions in an anhydrobiotic insect, Polypedilum vanderplanki
    Masahiko Watanabe
    Anhydrobiosis Research Unit, National Institute of Agrobiological Sciences, Ohwashi, Tsukuba, Ibaraki, Japan
    Int J Radiat Biol 82:835-42. 2006
    ..2 keV/microm). However, its tolerance against high LET radiation remains unknown. The aim of this study is to characterize the tolerance to high-LET radiations of P. vanderplanki...
  87. ncbi A system for three-dimensional dosimetric verification of treatment plans in intensity-modulated radiotherapy with heavy ions
    C P Karger
    Deutsches Krebsforschungszentrum, Abteilung Medizinische Physik, Heidelberg, Germany
    Med Phys 26:2125-32. 1999
    ..The system allows efficient verification and documentation of carbon ion fields and is in principle also applicable to intensity-modulated photon beams...
  88. ncbi Protective effects of melatonin against low- and high-LET irradiation
    Guangming Zhou
    Radiobiology Group, Institute of Modern Physics, Chinese Academy of Sciences, China
    J Radiat Res 47:175-81. 2006
    ..The results suggest that melatonin reduces the direct interaction of particles with cells rather than an indirect interaction. Further studies are required to disclose the underlying mechanisms...
  89. ncbi Chromosome aberration yields and apoptosis in human lymphocytes irradiated with Fe-ions of differing LET
    R Lee
    Biophysik, Gesellschaft fur Schwerionenforschung, Darmstadt, Germany
    Adv Space Res 35:268-75. 2005
    ..The significance of this observation for the estimation of the health risk associated with space radiation remains to be elucidated...
  90. ncbi Tumor induction in mice locally irradiated with carbon ions: a retrospective analysis
    Koichi Ando
    Heavy Ion Radiobiology Research Group, National Institute of Radiological Sciences, Chiba, Japan
    J Radiat Res 46:185-90. 2005
    ..2 for tumor induction and 1.9 for early skin reaction. We conclude that risk of secondary tumor induction by carbon-ion radiotherapy would not be seriously higher than anticipated...
  91. ncbi DNA DSB induced by iron ions in human fibroblasts: LET dependence and shielding efficiency
    G Esposito
    Laboratorio di Fisica, Technology and Health Department, Istituto Superiore di Sanita, Rome, Italy
    Adv Space Res 35:243-8. 2005
    ..Protection is only observed at high iron ions energy, especially at 5 GeV/u, where PMMA shield gives higher protection compared to Al or Pb shields of the same thickness expressed in g/cm2...
  92. ncbi High LET-induced H2AX phosphorylation around the Bragg curve
    N Desai
    NASA Johnson Space Center, Houston, TX 77058, USA
    Adv Space Res 35:236-42. 2005
    ....
  93. ncbi Analysis of secondary electron emission spectra of equal-LET protons and alpha particles for purposes of radiation quality and spaceflight hazard assessment
    P A Craven
    Institute of Cancer Research, University of London, London, UK
    Adv Space Res 35:300-4. 2005
    ..Such a method for numerically assessing radiation quality may have implications for procedures for heavy ion protection in space at low doses and for understanding the initial mechanisms of radiation action...
  94. ncbi Investigation of heavy-ion-induced sucrose radicals by electron paramagnetic resonance
    Kouichi Nakagawa
    RI Research Center, Fukushima Medical University, 1 Hikarigaoka, Fukushima, 960 1295, Japan
    Radiat Res 164:336-8. 2005
    ..In addition, the EPR response had a linear relationship with dose in the dose range of 5-60 Gy. Thus the present EPR results show that sucrose can be used to monitor the ionizing particle based on the radical yield...
  95. ncbi Mice heterozygous for the ATM gene are more sensitive to both X-ray and heavy ion exposure than are wildtypes
    B V Worgul
    Eye Radiation and Environmental Research Laboratory, Columbia University, New York, NY 10032, USA
    Adv Space Res 35:254-9. 2005
    ..The data show that heterozygosity for the ATM gene predisposes the eye to the cataractogenic influence of heavy ions and suggest that ATM heterozygotes in the human population may also be radiosensitive...
  96. ncbi Confocal fluorescent imaging of tracks from heavy charged particles utilising new Al2O3:C,Mg crystals
    Mark S Akselrod
    Landauer, Inc, Stillwater Crystal Growth Division, 723 1 2 Eastgate Road, Stillwater, OK 74074, USA
    Radiat Prot Dosimetry 119:357-62. 2006
    ..Fast neutrons were detected using recoil protons produced in a polyethylene radiator installed in front of the crystalline detector. Three-dimensional reconstruction of a recoil proton propagating through the crystal was demonstrated...
  97. ncbi High relative biologic effectiveness of carbon ion radiation on induction of rat mammary carcinoma and its lack of H-ras and Tp53 mutations
    Tatsuhiko Imaoka
    Experimental Radiobiology for Children s Health Research Group, Anagawa, Chiba, Japan
    Int J Radiat Oncol Biol Phys 69:194-203. 2007
    ..We undertook the present study to clarify the RBE of therapeutic carbon ion radiation and molecular changes that occur in the rat mammary cancer model...
  98. ncbi Doses and LET spectra in the beam of 12C with energy 500 MeV amu-1
    Iva Jadrnícková
    Department of Radiation Dosimetry, Nuclear Physics Institute AS CR, Na Truhlářce 39 64, 18086 Prague 8, Czech Republic
    Radiat Prot Dosimetry 122:488-90. 2006
    ..Data measured by means of a diamond detector and a spectrometer of linear energy transfer (LET) based on chemically etched track detectors are presented, analysed and discussed. LET spectra are also calculated by program SRIM...
  99. ncbi Experimental fragmentation studies with 12C therapy beams
    E Haettner
    Biophysik, Gesellschaft fur Schwerionenforschung, Planckstr 1, D 64291 Darmstadt, Germany
    Radiat Prot Dosimetry 122:485-7. 2006
    ..The preliminary results include energy- and angular distributions, fragment yields, build-up curves and attenuation of the primary carbon projectiles...
  100. doi Visualizing the dose distribution and linear energy transfer by 1D and 2D ESR imaging: a potassium dithionate dosimeter irradiated with C6+ and N7+ ions
    Hakan Gustafsson
    J Phys Chem B 112:8437-42. 2008
    ..and linear energy transfer (LET) in a potassium dithionate, K2S2O6 (PDT), dosimeter irradiated with the heavy ions C(6+) and N(7+)...
  101. ncbi Mammalian cells loaded with platinum-containing molecules are sensitized to fast atomic ions
    N Usami
    Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization, Oho, Tsukuba, Japan
    Int J Radiat Biol 84:603-11. 2008
    ..The experiment consists in irradiating by fast ions cultured cells previously exposed to dichloroterpyridine Platinum (PtTC) and analyzing cell survival by a colony-forming assay...

Research Grants16

  1. AGING, RADIATION & DNA DAMAGE IN NONDIVIDING TISSUE
    JOHN LETT; Fiscal Year: 1980
    ..Such studies are mutually complementary with experiments of the effects of heavy ions that are being conducted for NASA. 4...
  2. GEV HEAVY-ION AND 200 KV X-RAY EXCITATION OF DNA
    Malcolm Daniels; Fiscal Year: 1980
    ..Excitation sources will be 200kV X-ray, GeV heavy ions, 60Co gamma-rays, and synchrotron radiation...
  3. Radiation-Induced Mutagenesis and Apoptotic Regulation
    Amy Kronenberg; Fiscal Year: 2006
    ..It is the secondary mutations that lead to advance, aggressive disease in people. ..
  4. HIGH LET RADIATION & GENOMIC INSTABILITY IN HUMAN CELLS
    Amy Kronenberg; Fiscal Year: 2001
    ..The results obtained with low fluence iron-ion exposures will serve as a model for terrestrial exposures to radon and neutrons. ..
  5. Electron Transport in Tissue-Like Material
    LARRY TOBUREN; Fiscal Year: 2008
    ..The results will enhance our effort to establish clinically relevant radiation treatment with a better understanding of potential damage to healthy tissue. [unreadable] [unreadable] [unreadable]..
  6. Chemotherapy with injectable microdroplets
    FRANCESCO D ERRICO; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  7. Eighth International Workshop on Radiation Damage to DNA
    KATHRYN HELD; Fiscal Year: 2004
    ..abstract_text> ..
  8. HIGH ENERGY IONS AND GENOMIC INSTABILITY
    Eric Hall; Fiscal Year: 2001
    ....
  9. Prediction of Second Cancer Risks for Children Treated with Proton - vs. - Photon
    Wayne D Newhauser; Fiscal Year: 2010
    ..In the future, we expect that the lower-risk treatments will result in fewer second cancers and this will translate into longer, higher-quality lives for survivors of childhood cancer (presently 270,000 persons in the United States). ..
  10. Magnetic Flow Sorter for Pancreatic Islet Isolation
    Paul Todd; Fiscal Year: 2005
    ..abstract_text> ..
  11. Magnetic Sorter Channels for Stem Cells
    Paul Todd; Fiscal Year: 2006
    ..abstract_text> ..
  12. ENHANCED APOPTOSIS BY TARGETING PROTEIN REDOX STATUS
    Mohan Natarajan; Fiscal Year: 2009
    ..abstract_text> ..