Genomes and Genes
Summary: Positively charged particles composed of two protons and two neutrons, i.e., helium nuclei, emitted during disintegration of very heavy isotopes; a beam of alpha particles or an alpha ray has very strong ionizing power, but weak penetrability.
Publications256 found, 100 shown here
- Mechanistic modelling of genetic and epigenetic events in radiation carcinogenesisS G Andreev
Institute of Biochemical Physics, Moscow, Russia
Radiat Prot Dosimetry 122:335-9. 2006..As an alternative interpretation, it is possible that DNA damage can induce RINT indirectly via epigenetic process. A hypothetical epigenetic pathway for RINT is discussed...
- An overview of targeted alpha therapyYoung Seung Kim
Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, NCI, NIH, 10 Center Drive, Building 10, Rm B3B69, Bethesda, MD 20892 1002, USA
Tumour Biol 33:573-90. 2012The effectiveness of targeted α-therapy (TAT) can be explained by the properties of α-particles. Alpha particles are helium nuclei and are ~8,000 times larger than β(-)-particles (electrons)...
- Mechanism of radiation-induced bystander effect: role of the cyclooxygenase-2 signaling pathwayHongning Zhou
Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Proc Natl Acad Sci U S A 102:14641-6. 2005..These results provide evidence that the COX-2-related pathway, which is essential in mediating cellular inflammatory response, is the critical signaling link for the bystander phenomenon...
- Track structure, radiation quality and initial radiobiological events: considerations based on the PARTRAC code experienceDaniele Alloni
Laboratorio Energia Nucleare Applicata, Universita degli Studi di Pavia, Pavia, Italy
Int J Radiat Biol 88:77-86. 2012..In this paper a review of the track structure theory (and of its possible extension concerning non-DNA targets) is presented...
- High-linear energy transfer irradiation targeted to skeletal metastases by the alpha-emitter 223Ra: adjuvant or alternative to conventional modalities?Øyvind S Bruland
Faculty of Medicine, University of Oslo and Department of Oncology, The Norwegian Radium Hospital, Norway
Clin Cancer Res 12:6250s-6257s. 2006..Lastly, we present preliminary dose estimates for 223Ra in humans. Results indicate that repeated dosing is feasible and toxicity is low, and that opportunities are available for combined treatment strategies...
- Clinical experience with alpha-particle emitting 211At: treatment of recurrent brain tumor patients with 211At-labeled chimeric antitenascin monoclonal antibody 81C6Michael R Zalutsky
Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Nucl Med 49:30-8. 2008..The main goal of this study was to investigate the feasibility and safety of this approach in patients with recurrent malignant brain tumors...
- Intravesical alpha-radioimmunotherapy with 213Bi-anti-EGFR-mAb defeats human bladder carcinoma in xenografted nude miceBirgit Pfost
Department of Nuclear Medicine, Technische Universitat Munchen, Munich, Germany
J Nucl Med 50:1700-8. 2009....
- Intraperitoneal alpha-particle radioimmunotherapy of ovarian cancer patients: pharmacokinetics and dosimetry of (211)At-MX35 F(ab')2--a phase I studyHakan Andersson
Department of Oncology, University of Gothenburg, Gothenburg, Sweden
J Nucl Med 50:1153-60. 2009..The aim was to determine the pharmacokinetics for assessing absorbed dose to normal tissues and investigating toxicity...
- Induction and rejoining of DNA double-strand breaks in V79-4 mammalian cells following gamma- and alpha-irradiationT J Jenner
Division of Radiobiological Mechanisms, MRC Radiobiology Unit, Chilton, Didcot, UK
Int J Radiat Biol 64:265-73. 1993..It is inferred that the difference in repair of the various lesions is a reflection of the differences in the complexity of the clustered damage produced by these radiations...
- Intralesional targeted alpha therapy for metastatic melanomaBarry J Allen
Centre for Experimental Radiation Oncology, St George Hospital, Kogarah, NSW 2217, Australia
Cancer Biol Ther 4:1318-24. 2005..This paper reports the development and application of intralesional targeted alpha therapy (TAT) for melanoma, being the first part of a program to establish a new systemic therapy...
- Targeted alpha-radionuclide therapy of functionally critically located gliomas with 213Bi-DOTA-[Thi8,Met(O2)11]-substance P: a pilot trialD Cordier
Division of Neurosurgery, University Hospitals, Basel, Switzerland
Eur J Nucl Med Mol Imaging 37:1335-44. 2010..Therefore, we evaluated locally injected (213)Bi-DOTA-substance P in patients with critically located gliomas as the primary therapeutic modality...
- Sequential cytarabine and alpha-particle immunotherapy with bismuth-213-lintuzumab (HuM195) for acute myeloid leukemiaTodd L Rosenblat
Department of Medicine and the Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
Clin Cancer Res 16:5303-11. 2010..This phase I/II trial was conducted to determine the maximum tolerated dose (MTD) and antileukemic effects of (213)Bi-lintuzumab, the first targeted α-emitter, after partially cytoreductive chemotherapy...
- Effect of linear energy transfer (LET) on the complexity of alpha-particle-induced chromosome aberrations in human CD34+ cellsRhona M Anderson
MRC Radiation and Genome Stability Unit, Harwell, Didcot, Oxon, OX11 0RD, United Kingdom
Radiat Res 167:541-50. 2007The aim of this study was to assess the relative influence of the linear energy transfer (LET) of alpha particles on the complexity of chromosome aberrations in the absence of significant other differences in track structure...
- Radiation risk to low fluences of alpha particles may be greater than we thoughtH Zhou
Center for Radiological Research, College of Physicians and Surgeons, and Environmental Health Sciences, School of Public Health, Columbia University, New York, NY 10032, USA
Proc Natl Acad Sci U S A 98:14410-5. 2001....
- Tumour anti-vascular alpha therapy: a mechanism for the regression of solid tumours in metastatic cancerBarry J Allen
Phys Med Biol 52:L15-9. 2007..This effect depends on the expression of targeted receptors by capillary pericytes and contiguous cancer cells, and on the short-range and high-energy transfer of alpha radiation...
- Mitochondrial function and nuclear factor-kappaB-mediated signaling in radiation-induced bystander effectsHongning Zhou
Center for Radiological Research, College of Physicians and Surgeons, Mailman School of Public Health, Columbia University, New York, NY, USA
Cancer Res 68:2233-40. 2008....
- HPRT mutants induced in bystander cells by very low fluences of alpha particles result primarily from point mutationsL Huo
Department of Cancer Cell Biology, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
Radiat Res 156:521-5. 2001..5 or 10 cGy of alpha-particle radiation (0, 3% or 44%, respectively, of nuclei traversed by one or more alpha particles) were examined...
- Induction and quantification of gamma-H2AX foci following low and high LET-irradiationEmma L Leatherbarrow
DNA Damage Group, Radiation and Genome Stability Unit, Medical Research Council, Harwell, Oxfordshire, UK
Int J Radiat Biol 82:111-8. 2006....
- First clinical experience with alpha-emitting radium-223 in the treatment of skeletal metastasesSten Nilsson
Radiumhemmet, The Karolinska Hospital and Institute, Stockholm, Sweden
Clin Cancer Res 11:4451-9. 2005..The main goals were to study the safety and tolerability of the alpha-emitter radium-223 (223Ra) in breast and prostate cancer patients with skeletal metastases. In addition, pain palliation was evaluated...
- MIRD Pamphlet No. 22 (abridged): radiobiology and dosimetry of alpha-particle emitters for targeted radionuclide therapyGeorge Sgouros
Department of Radiology and Radiological Science, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21231, USA
J Nucl Med 51:311-28. 2010..The objective of this work is to review those aspects of the field that are pertinent to targeted alpha-particle emitter therapy and to provide guidance and recommendations for human alpha-particle emitter dosimetry...
- Comparison of RBE values of high-LET α-particles for the induction of DNA-DSBs, chromosome aberrations and cell reproductive deathNicolaas A P Franken
Department of Radiation Oncology, Laboratory for Experimental Oncology and Radiobiology, Centre for Experimental Molecular Medicine, University of Amsterdam, Amsterdam, The Netherlands
Radiat Oncol 6:64. 2011..Relevant information on RBE values might be derived from studies on cells in culture...
- Tumor therapy with targeted atomic nanogeneratorsM R McDevitt
Molecular Pharmacology and Therapeutics Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Science 294:1537-40. 2001..Nanogenerators targeting a wide variety of cancers may be possible...
- Targeted alpha particle immunotherapy for myeloid leukemiaJoseph G Jurcic
Department of Medicine, Memorial Sloan Kettering Cancer Center and Weill Medical College of Cornell University, New York, NY 10021, USA
Blood 100:1233-9. 2002..This study demonstrates the safety, feasibility, and antileukemic effects of (213)Bi-HuM195, and it is the first proof-of-concept for systemic targeted alpha particle immunotherapy in humans...
- Expression of CONNEXIN43 is highly sensitive to ionizing radiation and other environmental stressesEdouard I Azzam
Laboratory of Radiobiology, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
Cancer Res 63:7128-35. 2003..In contrast, the response after UV radiation varied and was cell type-dependent. Overall, these data suggest a critical role for genes involved in intercellular communication in mediating the cellular responses to a variety of stresses...
- In vitro and preclinical targeted alpha therapy of human prostate cancer with Bi-213 labeled J591 antibody against the prostate specific membrane antigenY Li
Centre for Experimental Radiation Oncology, Cancer Care Centre, St George Hospital, Kogarah, NSW, Australia
Prostate Cancer Prostatic Dis 5:36-46. 2002..Because of its in vitro cytotoxicity and these anti-proliferative properties in vivo, the (213)Bi-J591 conjugate has considerable potential as a new therapeutic agent for the treatment of prostate cancer...
- Importance of receptor density in alpha radioimmunotherapy in B cell malignancies: an in-vitro studyKatia Vandenbulcke
Department of Radiopharmacy, Ghent University, Belgium
Nucl Med Commun 25:1131-6. 2004..The development of RIT with alpha emitters is attractive because of the high linear energy transfer (LET) and short path length, allowing higher tumour cell kill and lower toxicity to healthy tissues...
- Evidence of extranuclear cell sensitivity to alpha-particle radiation using a microdosimetric model. I. Presentation and validation of a microdosimetric modelN Chouin
INSERM, U892, Nantes, F 44093 France
Radiat Res 171:657-63. 2009..Good agreements were also observed with previously published results...
- A multi-port low-fluence alpha-particle irradiator: fabrication, testing and benchmark radiobiological studiesPrasad V S V Neti
Department of Radiology, Division of Radiation Research, New Jersey Medical School, Newark, New Jersey 07103, USA
Radiat Res 161:732-8. 2004A new multi-port irradiator, designed to facilitate the study of the effects of low fluences of alpha particles on monolayer cultures, has been developed...
- A comparitive assessement of cytokine expression in human-derived cell lines exposed to alpha particles and X-raysVinita Chauhan
Consumer and Clinical Radiation Protection Bureau, Health Canada, Ottawa, ON, Canada
ScientificWorldJournal 2012:609295. 2012..These results suggest that certain proinflammatory cytokines may be involved in the biological effects related to α- particle exposure and the responses are cell type and radiation type specific...
- Novel approaches with track segment alpha particles and cell co-cultures in studies of bystander effectsC R Geard
Radiological Research Accelerator Facility, Center for Radiological Research, College of Physicians and Surgeons of Columbia University, 136 South Broadway, PO Box 21, Irvington, NY 10533, USA
Radiat Prot Dosimetry 99:233-6. 2002..This procedure allows for a defining of the factors responsible for initiating bystander effects and for determining their quantitative relevance...
- Bismuth-213 and actinium-225 -- generator performance and evolving therapeutic applications of two generator-derived alpha-emitting radioisotopesAlfred Morgenstern
European Commission, Joint Research Centre, Institute for Transuranium Elements, 76125 Karlsruhe, Germany
Curr Radiopharm 5:221-7. 2012..Selected preclinical studies are highlighted and the current clinical experience with (225)Ac and (213)Bi is summarized...
- No increase in radiation-induced chromosome aberration complexity detected by m-FISH after culture in the presence of 5'-bromodeoxyuridineNatalia D Sumption
MRC Radiation and Genome Stability Unit, Harwell, Didcot, Oxfordshire, OX11 0RD, UK
Mutat Res 594:30-8. 2006....
- Alpha particles as radiopharmaceuticals in the treatment of bone metastases: mechanism of action of radium-223 chloride (Alpharadin) and radiation protectionPhilippa J Cheetham
Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center, New York, New York 10032, USA
Oncology (Williston Park) 26:330-7, 341. 2012..The mechanism of action of Alpharadin and specifics of administration, radiation protection, and patient management will be discussed...
- Chromosome damage in human cells by γ rays, α particles and heavy ions: track interactions in basic dose-response relationshipsBradford D Loucas
Department of Radiation Oncology, The University of Texas Medical Branch, Galveston, Texas 77555, USA
Radiat Res 179:9-20. 2013..While such track interaction had been previously theorized, to the best of our knowledge, it has never been demonstrated experimentally...
- Gene expression profile of human lymphocytes exposed to (211)At alpha particlesA Turtoi
Forschungszentrum Julich, Department of Safety and Radiation Protection, Germany
Radiat Res 174:125-36. 2010..78 MeV mean energy alpha particles from extracellular (211)At. Lymphocytes were exposed to fluences of 0.3-9...
- The relationship between the RBE of alpha particles and the radiosensitivity of different mutations of Chinese hamster cellsN A Zyuzikov
Department of Radiation Biology, St. Bartholomew's and the Royal London School of Medicine and Dentistry, UK
Radiat Environ Biophys 40:243-8. 2001..Since cells with different defects of repair or cell cycle control have different radiosensitivities, we conclude that the effects of x-ray irradiation and the RBE are mostly determined by the activity of repair processes...
- The sensitivity of the alkaline comet assay in detecting DNA lesions induced by X rays, gamma rays and alpha particlesU Rössler
Federal Office for Radiation Protection, Department Radiation Protection and Health, Ingolstadter Landstrasse 1, 85764 Oberschleissheim, Germany
Radiat Prot Dosimetry 122:154-9. 2006..02 Gy for Am-241 and depicte a higher biological effectiveness. These results indicate that differences in biological effects arise through downstream processing of complex DNA damage...
- Characterisation of a setup for mixed beam exposures of cells to 241Am alpha particles and X-raysElina Staaf
Centre for Radiation Protection Research, GMT Department, Stockholm University, Svante Arrhenius väg 20C, 106 91 Stockholm, Sweden
Radiat Prot Dosimetry 151:570-9. 2012..The authors have constructed a facility where cells can be simultaneously exposed to (241)Am alpha particles and 190-kV X-rays at 37°C...
- Comparative cellular catabolism and retention of astatine-, bismuth-, and lead-radiolabeled internalizing monoclonal antibodyZ Yao
Department of Nuclear Medicine, Warren G. Magnuson Clinical Center, National Institutes of Health, 10 Center Dr, Bethesda, MD 20892-1180, USA
J Nucl Med 42:1538-44. 2001..These catabolism differences may be important in the selection of alpha-radionuclides for radioimmunotherapy...
- Alpha particles induce apoptosis through the sphingomyelin pathwayJonathan H Seideman
a Memorial Sloan Kettering Cancer Center, Department of Chemistry and Molecular Pharmacology, New York, New York 10065
Radiat Res 176:434-46. 2011..These data indicate that α particles can activate the sphingomyelin pathway to induce apoptosis...
- Radioimmunotherapy with alpha-particle emitting radionuclidesM R Zalutsky
Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA
Q J Nucl Med Mol Imaging 48:289-96. 2004..The current status of preclinical and clinical research with antibodies labeled with 3 promising alpha-particle emitting radionuclides - (213)Bi, (225)Ac, and (211)At - also will be summarized...
- Clinical trials of targeted alpha therapy for cancerBarry J Allen
Centre for Experimental Radiation Oncology, St George Hospital, Gray St Kogarah NSW 2217, Australia
Rev Recent Clin Trials 3:185-91. 2008..Results of past and current trials are reviewed, and the bases of some proposed trials are presented...
- A new mechanism for DNA alterations induced by alpha particles such as those emitted by radon and radon progenyB E Lehnert
Life Sciences Division, Los Alamos National Laboratory, New Mexico 87545, USA
Environ Health Perspect 105:1095-101. 1997..How transmissible factors like those observed here in vitro may extend to the in vivo condition in the context of a-particle-induced carcinogenesis in the respiratory tract remains to be determined...
- Alpha-particles for targeted therapyGeorge Sgouros
Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, School of Medicine, Baltimore MD USA
Adv Drug Deliv Rev 60:1402-6. 2008..Results from the small number of clinical trials reported to date have shown efficacy without significant toxicity...
- Radiofungicidal effects of external gamma radiation and antibody-targeted beta and alpha radiation on Cryptococcus neoformansRuth A Bryan
Department of Nuclear Medicine, Joint Research Centre, Institute for Transuranium Elements, Karlsruhe, Germany
Antimicrob Agents Chemother 52:2232-5. 2008..binding) of Cryptococcus neoformans cells subjected to gamma rays from an external source, and beta and alpha particles delivered to fungal cells by capsule-specific antibody...
- A comparison of cellular irradiation techniques with alpha particles using the Geant4 Monte Carlo simulation toolkitS Incerti
Centre d Etudes Nucléaires de Bordeaux Gradignan, CNRS IN2P3, Universite Bordeaux 1, Le Haut Vigneau, Gradignan Cedex, France
Radiat Prot Dosimetry 122:327-9. 2006..The simulation allows the calculation of hit distributions among the cellular population as well as the absorbed dose for two typical cellular geometries...
- Induction of linear tracks of DNA double-strand breaks by alpha-particle irradiation of cellsJan Stap
Center for Microscopical Research, Department of Cell Biology and Histology, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Nat Methods 5:261-6. 2008..of easily recognizable linear arrays of DSBs in nuclei of adherent eukaryotic cells by exposing the cells to alpha particles from a small Americium source (Box 1)...
- Development and characterization of an in vitro alpha radiation exposure systemLindsay A Beaton
Department of Physics, Carleton University, Ottawa, ON, Canada
Phys Med Biol 56:3645-58. 2011..steel discs with activities averaging 66 kBq and Mylar-based culture dishes to allow the transmission of alpha particles. The dosimetry of the exposure system was calculated using the GEANT4 Monte Carlo simulation toolkit with the ..
- Domestic radon risks may be dominated by bystander effects--but the risks are unlikely to be greater than we thoughtD J Brenner
Center for Radiological Research, Columbia University, 630 West 168th Street, New York, NY 10032, USA
Health Phys 85:103-8. 2003Radon risks derive from exposure of bronchio-epithelial cells to alpha particles. Alpha-particle exposure can result in bystander effects when irradiated cells emit signals resulting in damage to nearby unirradiated bystander cells...
- Double strand break rejoining after irradiation of human fibroblasts with X rays or alpha particles: PFGE studies and numerical modelsM Pinto
Gray Cancer Institute, PO Box 100, Mount Vernon Hospital, Northwood, Middlesex HA6 2JR, UK
Radiat Prot Dosimetry 99:133-6. 2002..of DNA double strand breaks (DSBs) induced in primary human fibroblasts by 240 kVp X rays and 238Pu alpha particles (110 keV.micron-1) were resolved using pulsed-field gel electrophoresis (PFGE)...
- Low doses of alpha particles do not induce sister chromatid exchanges in bystander Chinese hamster cells defective in homologous recombinationHatsumi Nagasawa
Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA
DNA Repair (Amst) 7:515-22. 2008..Furthermore, when irradiated with very low doses of alpha particles, SCEs were not induced in irs3 cells, as compared to a prominent bystander effect observed in V79 cells [H...
- Dose responses for chromosome aberrations produced in noncycling primary human fibroblasts by alpha particles, and by gamma rays delivered at sublimiting low dose ratesMichael N Cornforth
Departments of Radiation Oncology and Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas 77555 0656, USA
Radiat Res 158:43-53. 2002..Exposure to (238)Pu alpha particles also produced a linear dose response for total aberrations, whose slope-with respect to (137)Cs gamma rays as ..
- The role of promotion in carcinogenesis from protracted high-LET exposureS B Curtis
Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Phys Med 17:157-60. 2001..is suggested that the effect might be caused by a 'Bystander Effect' by which normal cells in the vicinity of initiated cells are hit by alpha particles and send out signals that modify the cell kinetics of the already-initiated clones.
- Lack of detectable transmissible chromosomal instability after in vivo or in vitro exposure of mouse bone marrow cells to 224Ra alpha particlesS D Bouffler
Radiation Effects Department, National Radiological Protection Board, Chilton, Didcot, Oxfordshire, OX11 0RQ, United Kingdom
Radiat Res 155:345-52. 2001..These findings emphasize the sensitivity of murine hemopoietic tissue to experimental manipulation and reinforce the importance of appropriate concurrent control experiments in any investigation of transmissible genomic instability...
- Comparison of different classes of radionuclides for potential use in radioimmunotherapyTom C Karagiannis
Trescowthick Research Laboratories, Peter MacCallum Cancer Centre, Melbourne, Australia
Hell J Nucl Med 10:82-8. 2007..The aim of this article is to discuss the different classes of radionuclides with potential for clinical use in radioimmunotherapy...
- Gene expression profiles in mouse liver cells after exposure to different types of radiationMehryar Habibi Roudkenar
Department of Pathology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
J Radiat Res 49:29-40. 2008..Anti-inflammatory treatment could be helpful for the prevention and protection of radiation-induced hepatic injury...
- Detection of chromosomal instability in alpha-irradiated and bystander human fibroblastsBrian Ponnaiya
Radiological Research Facility, Center for Radiological Research, Columbia University, 136 S Broadway, P O Box 21, Irvington, NY 10533, USA
Mutat Res 568:41-8. 2004..The results presented here support the link between the radiation-induced phenomena of genomic instability and the bystander effect...
- Bystander effect for chromosomal aberrations induced in wild-type and repair deficient CHO cells by low fluences of alpha particlesHatsumi Nagasawa
Department of Cancer Cell Biology, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
Mutat Res 508:121-9. 2002We have previously shown that when confluent cultures of mammalian cells are exposed to very low fluences of alpha particles, fluences whereby as few as 1% of the cell nuclei are traversed by a single particle, genetic effects including ..
- Extracellular factor(s) following exposure to alpha particles can cause sister chromatid exchanges in normal human cellsB E Lehnert
Cell and Molecular Biology Group, Life Sciences Division, Los Alamos National Laboratory, New Mexico 87545, USA
Cancer Res 57:2164-71. 1997The mechanism(s) by which alpha particles like those emitted from inhaled radon and radon progeny cause their mutagenic and carcinogenic effects remains unclear...
- Mutagenic effects of a single and an exact number of alpha particles in mammalian cellsT K Hei
Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Proc Natl Acad Sci U S A 94:3765-70. 1997..spectrum of S1- mutants induced in human-hamster hybrid (A(L)) cells by either a single or an exact number of alpha particles. Exponentially growing cells were stained briefly with a nontoxic concentration of Hoechst dye for image ..
- Vascular-targeted radioimmunotherapy with the alpha-particle emitter 211AtS J Kennel
Life Sciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, USA
Radiat Res 157:633-41. 2002..Work in this model system demonstrates that vascular targeting of alpha-particle emitters is an efficient therapy for small perivascular tumors and may be applicable to human disease when specific targeting agents are identified...
- Biochemical alterations in human cells irradiated with alpha particles delivered by macro- or microbeamsNathalie Gault
Commissariat a l Energie Atomique, Direction des Sciences du Vivant, Département de Radiobiologie Radiopathologie, 92265 Fontenay aux Roses, France
Radiat Res 167:551-62. 2007..irradiation and compared biochemical changes and DNA damage after targeted and nontargeted irradiation with alpha particles delivered by macro- or microbeams, using gamma radiation as a reference...
- Membrane-dependent bystander effect contributes to amplification of the response to alpha-particle irradiation in targeted and nontargeted cellsMaité Hanot
CEA, IRAMIS, SIS2M, F 91191 Gif sur Yvette, France
Int J Radiat Oncol Biol Phys 75:1247-53. 2009..Free radicals are believed to play an active role in the bystander response. This study investigated their origin as well as their temporal and spatial impacts in the bystander effect...
- Monte Carlo calculation of the maximum therapeutic gain of tumor antivascular alpha therapyChen Yu Huang
University of New South Wales, Kogarah, New South Wales, Australia
Med Phys 39:1282-8. 2012..The purpose of this paper is to quantitatively analyze the therapeutic efficacy and safety of TAVAT by building up the testing Monte Carlo microdosimetric models...
- Radioimmunotherapy with alpha-particle emitters: microdosimetry of cells with a heterogeneous antigen expression and with various diameters of cells and nucleiY Kvinnsland
Department of Nuclear Medicine, The Norwegian Radium Hospital, 0310, Norway
Radiat Res 155:288-96. 2001..The magnitudes of the differences were found to be a function of the fractions of mean specific energy delivered by surrounding activity and by activity bound to the cells...
- Monte-Carlo dosimetry on a realistic cell monolayer geometry exposed to alpha particlesPh Barberet
Universite Bordeaux, CENBG, UMR 5797, F 33170 Gradignan, France
Phys Med Biol 57:2189-207. 2012..The methodology presented in this paper provides microdosimetric quantities calculated from realistic cellular volumes. It is based on open-source oriented software that is publicly available...
- Alpha-particle emitting atomic generator (Actinium-225)-labeled trastuzumab (herceptin) targeting of breast cancer spheroids: efficacy versus HER2/neu expressionAse M Ballangrud
Memorial Sloan Kettering Cancer Center, New York, New York, USA
Clin Cancer Res 10:4489-97. 2004..225)Ac has a 10-day half-life and a decay scheme yielding four alpha-particles...
- Efforts to control the errant products of a targeted in vivo generatorJaspreet Singh Jaggi
Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Cancer Res 65:4888-95. 2005..0001). Metal chelation, diuresis with furosemide or chlorothiazide, and competitive metal blockade may be used as adjuvant therapies to modify the renal accumulation of 225Ac daughters...
- Micronuclei in human peripheral blood lymphocytes exposed to mixed beams of X-rays and alpha particlesElina Staaf
Stockholms universitet, Svante Arrhenius väg 20C, 10691 Stockholm, Sweden
Radiat Environ Biophys 51:283-93. 2012..was to analyse the cytogenetic effect of exposing human peripheral blood lymphocytes (PBL) to a mixed beam of alpha particles and X-rays...
- Delivery of the alpha-emitting radioisotope bismuth-213 to solid tumors via single-chain Fv and diabody moleculesG P Adams
Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
Nucl Med Biol 27:339-46. 2000..46) indicating that antigen-specific targeting was not a factor. This suggests that the physical half-life of (213)Bi may be too brief to be effectively paired with systemically-administered diabody or scFv molecules...
- Vascular targeted endoradiotherapy of tumors using alpha-particle-emitting compounds: theoretical analysisGamal Akabani
Department of Radiology, Duke University Medical Center, Box 3808, Durham, NC 27710, USA
Int J Radiat Oncol Biol Phys 54:1259-75. 2002..To establish the theoretical framework and study the feasibility of (211)At-labeled anti-tenascin chimeric 81C6 monoclonal antibody (mAb) as anti-vascular endoradiotherapy for the treatment of glioblastoma multiforme (GBM) tumors...
- Renal tubulointerstitial changes after internal irradiation with alpha-particle-emitting actinium daughtersJaspreet Singh Jaggi
Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
J Am Soc Nephrol 16:2677-89. 2005..These findings are dissimilar to those seen after gamma or beta irradiation of kidneys...
- Targeted alpha therapy: evidence for potential efficacy of alpha-immunoconjugates in the management of micrometastatic cancerB J Allen
Centre for Experimental Radiation Oncology, St George Cancer Care Centre, Kogarah, New South Wales, Australia
Australas Radiol 43:480-6. 1999..and because their cytotoxicity is the result of their high rate of energy loss and short range of the alpha particles. These radionuclides have properties that are particularly suited for the elimination of single cells in ..
- The early and initiation processes of radiation-induced bystander effects involved in the induction of DNA double strand breaks in non-irradiated culturesW Han
Key Laboratory of Ion Beam Bioengineering, Institute of Plasma Physics, Chinese Academy of Sciences, Hefei, Anhui 230031, People s Republic of China
Br J Radiol 80:S7-12. 2007..might be involved in these processes...
- Studies of bystander effects in human fibroblasts using a charged particle microbeamK M Prise
Gray Laboratory Cancer Research Trust, Mount Vernon Hospital, Northwood, Middlesex, UK
Int J Radiat Biol 74:793-8. 1998..To determine the role of cell-to-cell mediated effects in the response of cells to different radiations by using a charged particle microbeam capable of targeting individual cells with counted particles...
- Ac-225 and her daughters: the many faces of ShivaM R McDevitt
Cell Death Differ 9:593-4. 2002
- 211At radioimmunotherapy of subcutaneous human ovarian cancer xenografts: evaluation of relative biologic effectiveness of an alpha-emitter in vivoTom Bäck
Department of Radiation Physics, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
J Nucl Med 46:2061-7. 2005..This study was performed to evaluate the relative biological effectiveness (RBE) of 211At compared with that of 60Co gamma-irradiation in an RIT model. Our endpoint was growth inhibition (GI) of subcutaneous xenografts...
- Gross alpha and beta activity analysis in water--a routine laboratory method using liquid scintillation analysisRoss I Kleinschmidt
Queensland Health Scientific Services, P O Box 594 Archerfield, QD 4108, Australia
Appl Radiat Isot 61:333-8. 2004..The results show that the LSA method exceeds performance of the ISO methods in measurement accuracy...
- Cell death triggered by alpha-emitting 213Bi-immunoconjugates in HSC45-M2 gastric cancer cells is different from apoptotic cell deathChristof Seidl
Department of Nuclear Medicine, Technische Universitat Munchen, Ismaninger Strasse 22, 81675, Munich, Germany
Eur J Nucl Med Mol Imaging 32:274-85. 2005..The aim of this study was to investigate cellular damage and the mode of cell death triggered by 213Bi-immunoconjugates...
- A comparison of high- versus low-linear energy transfer somatostatin receptor targeted radionuclide therapy in vitroTapan Nayak
Radiopharmaceutical Sciences Program, College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, NM 87131 0001, USA
Cancer Biother Radiopharm 20:52-7. 2005..The somatostatin analog [DOTA(0)-Tyr(3)]-octreotide (DOTATOC) has been widely used to target somatostatin receptor expressing tumors for therapy using radionuclides such as (90)Y or (177)Lu...
- Production and validation of CR-39-based dishes for alpha-particle radiobiological experimentsSylvain Gaillard
Laboratoire de Microanalyses Nucleaires, UFR Sciences et Techniques, Universite de Franche Comte, 25030 Besancon Cedex, France
Radiat Res 163:343-50. 2005The study of radiobiological effects induced in vitro by low fluences of alpha particles would be significantly enhanced if the precise localization of each particle track in the cell monolayer was known...
- Measuring method of undamaged samples for the radiation levels of decorative building materialsMao Yahong
Physics and Electronics Department, University of Electronic Science and Technology of China, Chendu 610054, China
Health Phys 87:75-8. 2004..The surface alpha ray flux of materials cannot be used to estimate the internal and external exposure indexes of color-glazed tiles...
- Microdosimetry of inhomogeneous radon progeny distributions in bronchial airwaysH Fakir
Institut de Radioprotection et de Surete Nucleaire, DRPH SDI, B P no 17, F 92262 Fontenay aux Roses Cedex, France
Radiat Prot Dosimetry 113:129-39. 2005A Monte Carlo code, initially developed for the calculation of microdosimetric spectra for alpha particles in cylindrical airways, has been extended to allow the computation (i) of additional microdosimetric parameters and (ii) for ..
- Effect of a grounded object on radon measurement using AlphaGUARDHirokazu Ichitsubo
Radon Research Group, Research Center for Radiation Safety, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage, Chiba 263 8555, Japan
Health Phys 87:79-81. 2004..When the connector is grounded, the radon concentration is again falsely measured as 0 Bq m. If the nozzle or connector is ungrounded, the AlphaGUARD measures radon concentration accurately. Health Phys...
- A microbeam study of DNA double-strand breaks in bystander primary human fibroblastsL B Smilenov
Center for Radiological Research, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
Radiat Prot Dosimetry 122:256-9. 2006..Utilising the Columbia University single-cell microbeam system to deliver 2 or 20 individual alpha particles to selected cell nuclei in a precisely known proportion of cells in a population, the induced DNA DSB ..
- Bound PCNA in nuclei of primary rat tracheal epithelial cells after exposure to very low doses of plutonium-238 alpha particlesM A Hill
Medical Research Council, Radiation and Genome Stability Unit, Harwell, Oxfordshire, OX11 0RD, United Kingdom
Radiat Res 163:36-44. 2005..Examination by immunofluorescence techniques of tracheal cell cultures after exposure to very low doses of alpha particles revealed a large proportion of cells with proliferating cell nuclear antigen (PCNA) bound in their nuclei...
- The influence of radiation quality on radiation-induced hemolysis and hemoglobin oxidation of human erythrocytesMieczysław Puchała
Department of Molecular Biophysics, University of Łódź, Poland
J Radiat Res 45:275-9. 2004..These results are interpreted by proposing that OH-radicals, whose yields are smaller with densely ionizing radiation, play a crucial role in the induction of the processes for radiation-induced erythrocyte damage...
- Pretargeted alpha emitting radioimmunotherapy using (213)Bi 1,4,7,10-tetraazacyclododecane-N,N',N",N"'-tetraacetic acid-biotinZhengsheng Yao
Department of Nuclear Medicine, Warren G Magnuson Clinical Center, NIH, Bethesda, Maryland 20892, USA
Clin Cancer Res 10:3137-46. 2004..This study investigated the biodistribution of bismuth-labeled biotin in A431 tumor-bearing mice pretargeted with antibody B3-streptavidin (B3-SA) and examined the therapeutic efficacy of the alpha emitter, (213)Bi-labeled biotin...
- Microdosimetry of radon progeny alpha particles in bronchial airway bifurcationsH Fakir
Division of Physics and Biophysics, Department of Molecular Biology, University of Salzburg, Hellbrunner Strasse 34, A 5020 Salzburg, Austria
Radiat Prot Dosimetry 117:382-94. 2005A Monte Carlo code, initially developed for the calculation of microdosimetric spectra for alpha particles in cylindrical airways, has been extended to allow the computation of microdosimetric parameters for multiple source-target ..
- Alpha-particle Monte Carlo simulation for microdosimetric calculations using a commercial spreadsheetJohn C Roeske
Department of Radiation and Cellular Oncology, University of Chicago, 5758 S Maryland Ave, MC 9006, Chicago, IL 60637, USA
Phys Med Biol 52:1909-22. 2007..Thus, the spreadsheet Monte Carlo method represents a simple and efficient method to calculate single-event spectra for alpha-particle emitters. Copies of the spreadsheet are available from the corresponding author upon request...
- Simple experimental method for alpha particle range determination in lead iodide filmsYuri Dmitriev
Radiation Monitoring Devices Inc, Watertown, MA 02472, USA
Rev Sci Instrum 78:053907. 2007An experimental method for determining the range of alpha particles in films based on I-V(s) analysis has been suggested. The range of 5...
- Incorporation of microdosimetric concepts into a biologically-based model of radiation carcinogenesisH Fakir
Division of Physics and Biophysics, Department of Molecular Biology, University of Salzburg, Hellbrunner Strasse 34, A 5020 Salzburg, Austria
Radiat Prot Dosimetry 122:330-4. 2006..Such an approach allows the consideration of hit frequencies and the variability of the specific energy and LET spectra of radon progeny alpha particles in bronchial target cells for different exposure conditions.
- [Alpha-radioimmunotherapy: a review of recent developments]S Supiot
Service de Radiotherapie, Centre Rene Gauducheau, Boulevard Jacques Monod, 44800 Nantes Saint Herblain, France
Cancer Radiother 11:252-9. 2007..This review aims at presenting recent advances of this therapeutic approach, and at detailing the biological specificities of this kind of radiation...
- Simulation of the measured ionisation-cluster distributions of alpha-particles in nanometric volumes of propaneL De Nardo
INFN Laboratori Nazionali di Legnaro, Viale dell Universita 2, I 35020 Legnaro, Padova, Italy
Radiat Prot Dosimetry 122:427-31. 2006In the last years, the probability of the formation of ionisation clusters by primary alpha particles at 5.4 MeV in nanometric volumes of propane (20.6 and 24.0 nm in a material of density 1...
- Effects of low and high LET radiations on bystander human lung fibroblast cell survivalRajamanickam Baskar
Center for Radiological Research, Department of Radiation Oncology, College of Physicians and Surgeons, Columbia University, New York, USA
Int J Radiat Biol 83:551-9. 2007....
- The distribution of the number of alpha hits per target cell: a new parameter to improve risk assessment for cancer induction using ICRP modelsP Fritsch
Laboratoire de Radiotoxicologie, SRCA DRR DSV CEA, BP 12, 91680 Bruyères le Châtel, France
Radiat Prot Dosimetry 127:46-9. 2007..This underlines the uncertainties in risk assessment associated with a dose rate effect...
- Design, spectrum measurements and simulations for a 238Pu alpha-particle irradiator for bystander effect and genomic instability experimentsArvi Hakanen
STUK Radiation and Nuclear Safety Authority P O Box 14, FIN 00881 Helsinki, Finland
Appl Radiat Isot 64:864-7. 2006..Mean energies and full-widths at half-maximum (FWHM) were calculated for the three different helium gas tracks...
- Optical excitation of LiF:Mg,Ti following alpha and beta irradiationY S Horowitz
Physics Department, Ben Gurion University, Beer Sheva 84105, Israel
Radiat Prot Dosimetry 119:386-9. 2006....
- Choosing an alpha radiation weighting factor for doses to non-human biotaDouglas B Chambers
SENES Consultants Limited, 121 Granton Drive, Unit 12, Richmond Hill, Ontario L4B 3N4, Canada
J Environ Radioact 87:1-14. 2006..The relevancy of each experimental result in selecting a radiation weighting factor for doses from alpha particles in biota was judged on the basis of criteria established a priori...
- A composite microdose Adaptive Response (AR) and Bystander Effect (BE) model-application to low LET and high LET AR and BE dataBobby E Leonard
International Academy, 693 Wellerburn Road, Severna Park, Maryland 21146, USA
Int J Radiat Biol 84:681-701. 2008....
- Innovative procedure for the determination of gross-alpha/gross-beta activities in drinking waterS Wisser
Rhine Main Water Research Ltd, Kurfürstenstr 6, D 65203 Wiesbaden, Germany
Appl Radiat Isot 64:368-72. 2006..The limits of detection for gross-alpha and gross-beta activity are in the range 25-210 mBq/l, respectively, for a measurement time of only 8-9 h...
- Targeting alpha particle-emitting radionuclides to the nuclei of cancer cellsThomas Quinn; Fiscal Year: 2007..unreadable] [unreadable] [unreadable] [unreadable]..
- Cancer Mortality among Military Participants at U.S. Nuclear Weapons TestsJOHN DUNNING BOICE; Fiscal Year: 2013..Ground between 1946 and 1958 could have been exposed to various types of radiation including gamma rays, alpha particles and intakes of radioactive substances such as plutonium, uranium and fallout products...
- Novel Receptor-Targeting Theranostic Peptides for Prostate CancerYubin Miao; Fiscal Year: 2013....
- Targeted therapy of pancreatic cancer with in vivo radionuclide generatorEkaterina Dadachova; Fiscal Year: 2012..If successful, this approach offers the possibility of cure for PCa. ..
- Peptide-targeted alpha-particle emitting phage for ovarian cancer therapy.Thomas P Quinn; Fiscal Year: 2013..b>Alpha particles are helium 4He ions that result in high linear energy transfer (LET) upon emission, significantly higher than ..
- Improving therapy of glioblastoma multiforme by enhancing therapeutic drug deliveMichael R McDevitt; Fiscal Year: 2013..in GBM;locally irradiate those vessels and the adjacent perivascular cancer stem cell niche with cytotoxic alpha particles;and favorably remodel the vascular endothelium and improve subsequent chemotherapy...
- Protection against radiation-induced damage to intestinal nutrient transportRoger Howell; Fiscal Year: 2009..Three sources of radiation will be used in each aim: acute 137Cs gamma rays, chronic 137Cs gamma rays, and alpha particles from 210Po. We have found that vitamins mitigate biological effects of low- and high-LET radiation in testes...
- INORGANIC ION EXCHANGERS FOR 213BI GENERATORSPaul Sylvester; Fiscal Year: 1999..By contrast, alpha particles are thousands of times more efficient at destroying cancer cells and have a range of only a few mu m, ..
- Cytoplasmic Damage and GenotoxicityTom K Hei; Fiscal Year: 2013..A state of the art charge particle microbeam that can deliver a precise number of alpha particles with a beam size of ~ 1 micrometer and a precision greater than 98% provides an unprecedented opportunity to ..
- BYSTANDER EFFECTS OF LOW DOSE ALPHA PARTICLESBruce Lehnert; Fiscal Year: 2001..of the process may involve the induction of mechanisms in cells that do not receive direct exposure to alpha particles. These so called "bystander effects" can be mediated via fluid-phase, extracellular factors and, perhaps, ..
- RADON, BRONCHIAL MORPHOMETRY, AND OCCUPATIONAL HEALTHDavid Brenner; Fiscal Year: 1993..in smokers and non smokers, to estimate the energy deposition characteristics of the radon-daughter alpha particles, in the cells at risk in the bronchial epithelia of miners and the general public; 3) combine the data from (..
- RECEPTOR MEDIATED RADIATION ONCOLOGYWILLIAM BLOOMER; Fiscal Year: 1991..on the possibility of using the radiotoxicity of Auger and alpha emitters for cancer treatment; in the field of cellular and molecular radiation biology, the emphasis is on the mechanism of action of alpha particles and the Auger effect.
- IMAGING OF BORON IN TISSUE AT CELLULAR LEVEL FOR BNCTTOM WHITAKER; Fiscal Year: 1991..Since the ranges of the alpha particles and lithium ions that result from the capture are very short (mum), the clinical efficacy is only guaranteed ..
- ROLES OF HUMAN RECOMBINATION GENES IN GENOME INSTABILITYDavid Chen; Fiscal Year: 2001..Limited studies with alpha particles have also suggested that high linear energy transfer (LET) radiation is more potent than low LET gamma rays ..
- MELANOMA RADIOTHERAPY- PEPTIDE TARGETED ALPHA-RADIATIONThomas Quinn; Fiscal Year: 2000..proposed commercial application: not available ..
- Chelator for a Therapeutic Ra-223 RadiopharmaceuticalTERESIA MOLLER; Fiscal Year: 2004..The high linear energy transfer (LET) and relatively short penetration range (a few cell diameters) makes alpha particles particularly attractive for the treatment of micro tumors...
- Melanoma Therapy via peptide targeted alpha-radiationThomas Quinn; Fiscal Year: 2004..DOTA]-ReCCMSH targeting of Alpha-particle emitting radiation to melanoma tumors in patients with metastatic disease. ..
- CANCER INCIDENCE IN URANIUM MINERS EXPOSED TO RADONRadim Sram; Fiscal Year: 1999....
- RADIATION, CHROMOSOMAL ABERRATIONS, AND RELATIVE BIOLOGIJoel Bedford; Fiscal Year: 2002..This would be studied by comparing the induction of exchange aberrations after exposing cells to 5 MeV alpha particles with that from damage after decay of 125IUdR incorporated into DNA...
- RADON PROGENY LUNG DOSE MONITORHARVEL WRIGHT; Fiscal Year: 1991..within the human respiratory tract and an alpha particle spectrometer to detect and measure the energy of alpha particles that would be produced by these radon progeny...
- ZINC SULFIDE AS A SPECT SCINTILLATORBrian Fitzpatrick; Fiscal Year: 1992..has long been known as an efficient scintillator: it was used in powder form by Rutherford for detection of alpha particles and continues to be used for that purpose...
- CYTOGENETIC EFFECTS PERTAINING TO LOW DOSES OF RADIATIONMichael Cornforth; Fiscal Year: 1991..This would allow the accurate measurement of radiation-induced chromosome breaks caused by doses well below 10 rad...
- Molecular Cages for Alpha Particle RadioimmunotherapyMICHAEL DIENER; Fiscal Year: 2002..The development of such a therapy has a potential market of approximately 300,000 Americans/yr. ..
- MECHANISMS OF MUTAGENESIS BY SINGLE ALPHA PARTICLESTOM HEI; Fiscal Year: 2000..Preliminary data also suggest that irradiation of cellular cytoplasm alone with 4 or more alpha particles induces mutation at the S1 locus at a frequency two fold above the spontaneous level...
- MODELING AND DOSIMETRY FOR RADIOLABELED ANTIBODY THERAPYGeorge Sgouros; Fiscal Year: 2002....
- Targeted Alpha-Particle Emitter Therapy of MetastasesGeorge Sgouros; Fiscal Year: 2009..The work described in this application is intended to develop and evaluate such an approach. ..
- Astatine 211 & Radioiodine Labeled Octreotide ConjugatesMichael Zalutsky; Fiscal Year: 2004..The proposed in vitro studies include characterization of binding, internalization and catabolism; the proposed in vivo studies include evaluation of tissue distribution, dosimetry, catabolism as well as therapeutic efficacy. ..
- ASTATINE AND IODINE RADIOLABELED MONOCLONAL ANTIBODIESMichael Zalutsky; Fiscal Year: 2008..abstract_text> ..
- High Stability Accelerator for Sub-Cellular MicrobeamDavid Brenner; Fiscal Year: 2003..We have considerably more demand for microbeam time than we can cope with, primarily because of limited physicist manpower. ..
- RADIOLOGICAL RESEARCH ACCELERATOR FACILITY (RARAF)David Brenner; Fiscal Year: 2002..abstract_text> ..
- Cancer Risks Attributable To Radiation from Pediatric CTDavid Brenner; Fiscal Year: 2006..The target audiences will be radiologists, pediatricians, family physicians, and the CT industry. We will use telephone interviews supplemented with survey questions, to aid in web content decisions. ..
- MECHANISMS OF ARSENIC CARCINOGENESISTOM HEI; Fiscal Year: 2005..abstract_text> ..
- HIGH ENERGY IONS AND GENOMIC INSTABILITYEric Hall; Fiscal Year: 2001..human bronchial epithelial cells with a single low dose of high energy (1 GeV/nucleon) iron ions or with alpha particles so that, after in vitro culture for many generations, they become tumorigenic in nude mice...
- THE MUTAGENICITY OF MINERAL FIBERSTOM HEI; Fiscal Year: 2006..By using specific DNA probes of other genes that have been regionally mapped to various sites on chromosome 11, the molecular spectrum of mutations induced by either asbestos or glass fiber control will be compared. ..
- MECHANISMS OF FIBER CARCINOGENESISTOM HEI; Fiscal Year: 2001..Cytogenetic and molecular alterations at the gene level will be analyzed from tumors and intermediate transformation stages to provide a mechanistic basis for tumor induction by mineral fibers. ..
- Production of High Specific Activity Lutetium-177Cathy Cutler; Fiscal Year: 2005..If impurities are present, develop methods to prevent their introduction or to remove them from the final product. Perform radiolabelling of the Lu-177 produced to molecules of interest in therapeutic applications. ..
- Molecular Targeting of EGFR for the Treatment of GliomasROLF BARTH; Fiscal Year: 2006..second generation drugs BPA and BSH, produce a significant improvement in survival following BNCT compared to that which we have obtained with BSH and BPA in combination, using the F98EGFR and F98EGFRVIII glioma models?" ..
- TUMOR SUPPRESSOR GENE METHYLATION IN LUNG ADENOCARCINOMASteven A Belinsky; Fiscal Year: 2010..Transient transfection of minimized promoters into cell lines with an endogenously active or silenced gene will be used to elucidate the sequence of changes involved in repression of promoter activity. REVISED: July 7, 2005 ..
- RADIODIAGNOSIS & RADIOTHERAPY OF LUNG CANCER METASTASESAMIN KASSIS; Fiscal Year: 2004....
- Imaging of O6-Alkylguanine-DNA AlkyltransferaseGanesan Vaidyanathan; Fiscal Year: 2005..In summary, this proposal seeks to determine whether the development of a suitable agent for the imaging of tumor AGT will facilitate chemotherapy planning, thereby improving the outcome of alkylator chemotherapy. ..
- Gene Methylation and Therapeutic Response in Lung CancerSteven Belinsky; Fiscal Year: 2005..The validation of these genes as biomarkers of lung cancer risk and their detection in sputum and/or serum could ultimately support chemoprevention trials for preventing lung cancer. ..
- MARKERS FOR LUNG CARCINOGENESIS IN BRONCHIAL EPITHELIUMSteven Belinsky; Fiscal Year: 2001..f., simply markers of exposure) and help identify genetic alterations that are candidate markers of respiratory carcinogenesis. ..
- Damage signaling from irradiated to non-irradiated cellsEDOUARD AZZAM; Fiscal Year: 2004..They are also relevant to diagnostic and therapeutic nuclear medicine where radionuclides are being investigated to detect various diseases and treat cancer. ..
- MIBG ANALOGUE RADIOPHARMACEUTICALSGanesan Vaidyanathan; Fiscal Year: 2001..Strategies to augment tumor-to-normal tissue ratios will be investigated. The outcome of this study should help improve the endoradiotherapy of neuroendocrine tumors and possibly of medulloblastoma. ..
- TARGETED METAL CHELATORS FOR DIAGNOSTIC IMAGINGMichael Welch; Fiscal Year: 2001..The synthesis characterization and physicochemical studies will be carried out at Texas A&M University while the in vitro and in vivo evaluation of the pharmaceutical preparations will be undertaken at Washington University. ..
- GENETIC/ CYTOGENETIC INSTABILITY OF IONIZING RADIATIONMichael Cornforth; Fiscal Year: 2002....
- RADIOIMMUNOTHERAPY OF B CELL LYMPHOMA WITH ANTI CD74M Mattes; Fiscal Year: 2002..This study may lead to the development of more effective radio-conjugates for the therapy of cancer and other diseases. Also, it will provide basic information about the toxic effects of intracellular (really lysosomal) radionuclides. ..
- Regulation of BCL-2 and TumorigenicityMarc Mendonca; Fiscal Year: 2006..abstract_text> ..
- PET RADIOPHARMACEUTICALS FOR CARDIAC AND OTHER STUDIESMichael Welch; Fiscal Year: 2002..The overall goal of this application is to develop and evaluate new PET radiopharmaceuticals that have potential for evaluating diseases of th heart, lung, and vasculature. ..