alpha particles

Summary

Summary: Positively charged particles composed of two protons and two neutrons, i.e., helium nuclei, emitted during disintegration of very heavy isotopes; a beam of alpha particles or an alpha ray has very strong ionizing power, but weak penetrability.

Top Publications

  1. ncbi Mechanistic modelling of genetic and epigenetic events in radiation carcinogenesis
    S G Andreev
    Institute of Biochemical Physics, Moscow, Russia
    Radiat Prot Dosimetry 122:335-9. 2006
  2. ncbi An overview of targeted alpha therapy
    Young Seung Kim
    Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, NCI, NIH, 10 Center Drive, Building 10, Rm B3B69, Bethesda, MD 20892 1002, USA
    Tumour Biol 33:573-90. 2012
  3. pmc Mechanism of radiation-induced bystander effect: role of the cyclooxygenase-2 signaling pathway
    Hongning Zhou
    Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 102:14641-6. 2005
  4. ncbi Track structure, radiation quality and initial radiobiological events: considerations based on the PARTRAC code experience
    Daniele Alloni
    Laboratorio Energia Nucleare Applicata, Universita degli Studi di Pavia, Pavia, Italy
    Int J Radiat Biol 88:77-86. 2012
  5. ncbi High-linear energy transfer irradiation targeted to skeletal metastases by the alpha-emitter 223Ra: adjuvant or alternative to conventional modalities?
    Øyvind S Bruland
    Faculty of Medicine, University of Oslo and Department of Oncology, The Norwegian Radium Hospital, Norway
    Clin Cancer Res 12:6250s-6257s. 2006
  6. pmc Clinical experience with alpha-particle emitting 211At: treatment of recurrent brain tumor patients with 211At-labeled chimeric antitenascin monoclonal antibody 81C6
    Michael R Zalutsky
    Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Nucl Med 49:30-8. 2008
  7. ncbi Intravesical alpha-radioimmunotherapy with 213Bi-anti-EGFR-mAb defeats human bladder carcinoma in xenografted nude mice
    Birgit Pfost
    Department of Nuclear Medicine, Technische Universitat Munchen, Munich, Germany
    J Nucl Med 50:1700-8. 2009
  8. ncbi Intraperitoneal alpha-particle radioimmunotherapy of ovarian cancer patients: pharmacokinetics and dosimetry of (211)At-MX35 F(ab')2--a phase I study
    Hakan Andersson
    Department of Oncology, University of Gothenburg, Gothenburg, Sweden
    J Nucl Med 50:1153-60. 2009
  9. ncbi Induction and rejoining of DNA double-strand breaks in V79-4 mammalian cells following gamma- and alpha-irradiation
    T J Jenner
    Division of Radiobiological Mechanisms, MRC Radiobiology Unit, Chilton, Didcot, UK
    Int J Radiat Biol 64:265-73. 1993
  10. ncbi Intralesional targeted alpha therapy for metastatic melanoma
    Barry J Allen
    Centre for Experimental Radiation Oncology, St George Hospital, Kogarah, NSW 2217, Australia
    Cancer Biol Ther 4:1318-24. 2005

Detail Information

Publications256 found, 100 shown here

  1. ncbi Mechanistic modelling of genetic and epigenetic events in radiation carcinogenesis
    S G Andreev
    Institute of Biochemical Physics, Moscow, Russia
    Radiat Prot Dosimetry 122:335-9. 2006
    ..As an alternative interpretation, it is possible that DNA damage can induce RINT indirectly via epigenetic process. A hypothetical epigenetic pathway for RINT is discussed...
  2. ncbi An overview of targeted alpha therapy
    Young Seung Kim
    Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, NCI, NIH, 10 Center Drive, Building 10, Rm B3B69, Bethesda, MD 20892 1002, USA
    Tumour Biol 33:573-90. 2012
    The effectiveness of targeted α-therapy (TAT) can be explained by the properties of α-particles. Alpha particles are helium nuclei and are ~8,000 times larger than β(-)-particles (electrons)...
  3. pmc Mechanism of radiation-induced bystander effect: role of the cyclooxygenase-2 signaling pathway
    Hongning Zhou
    Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 102:14641-6. 2005
    ..These results provide evidence that the COX-2-related pathway, which is essential in mediating cellular inflammatory response, is the critical signaling link for the bystander phenomenon...
  4. ncbi Track structure, radiation quality and initial radiobiological events: considerations based on the PARTRAC code experience
    Daniele Alloni
    Laboratorio Energia Nucleare Applicata, Universita degli Studi di Pavia, Pavia, Italy
    Int J Radiat Biol 88:77-86. 2012
    ..In this paper a review of the track structure theory (and of its possible extension concerning non-DNA targets) is presented...
  5. ncbi High-linear energy transfer irradiation targeted to skeletal metastases by the alpha-emitter 223Ra: adjuvant or alternative to conventional modalities?
    Øyvind S Bruland
    Faculty of Medicine, University of Oslo and Department of Oncology, The Norwegian Radium Hospital, Norway
    Clin Cancer Res 12:6250s-6257s. 2006
    ..Lastly, we present preliminary dose estimates for 223Ra in humans. Results indicate that repeated dosing is feasible and toxicity is low, and that opportunities are available for combined treatment strategies...
  6. pmc Clinical experience with alpha-particle emitting 211At: treatment of recurrent brain tumor patients with 211At-labeled chimeric antitenascin monoclonal antibody 81C6
    Michael R Zalutsky
    Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Nucl Med 49:30-8. 2008
    ..The main goal of this study was to investigate the feasibility and safety of this approach in patients with recurrent malignant brain tumors...
  7. ncbi Intravesical alpha-radioimmunotherapy with 213Bi-anti-EGFR-mAb defeats human bladder carcinoma in xenografted nude mice
    Birgit Pfost
    Department of Nuclear Medicine, Technische Universitat Munchen, Munich, Germany
    J Nucl Med 50:1700-8. 2009
    ....
  8. ncbi Intraperitoneal alpha-particle radioimmunotherapy of ovarian cancer patients: pharmacokinetics and dosimetry of (211)At-MX35 F(ab')2--a phase I study
    Hakan Andersson
    Department of Oncology, University of Gothenburg, Gothenburg, Sweden
    J Nucl Med 50:1153-60. 2009
    ..The aim was to determine the pharmacokinetics for assessing absorbed dose to normal tissues and investigating toxicity...
  9. ncbi Induction and rejoining of DNA double-strand breaks in V79-4 mammalian cells following gamma- and alpha-irradiation
    T J Jenner
    Division of Radiobiological Mechanisms, MRC Radiobiology Unit, Chilton, Didcot, UK
    Int J Radiat Biol 64:265-73. 1993
    ..It is inferred that the difference in repair of the various lesions is a reflection of the differences in the complexity of the clustered damage produced by these radiations...
  10. ncbi Intralesional targeted alpha therapy for metastatic melanoma
    Barry J Allen
    Centre for Experimental Radiation Oncology, St George Hospital, Kogarah, NSW 2217, Australia
    Cancer Biol Ther 4:1318-24. 2005
    ..This paper reports the development and application of intralesional targeted alpha therapy (TAT) for melanoma, being the first part of a program to establish a new systemic therapy...
  11. ncbi Targeted alpha-radionuclide therapy of functionally critically located gliomas with 213Bi-DOTA-[Thi8,Met(O2)11]-substance P: a pilot trial
    D Cordier
    Division of Neurosurgery, University Hospitals, Basel, Switzerland
    Eur J Nucl Med Mol Imaging 37:1335-44. 2010
    ..Therefore, we evaluated locally injected (213)Bi-DOTA-substance P in patients with critically located gliomas as the primary therapeutic modality...
  12. pmc Sequential cytarabine and alpha-particle immunotherapy with bismuth-213-lintuzumab (HuM195) for acute myeloid leukemia
    Todd L Rosenblat
    Department of Medicine and the Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Clin Cancer Res 16:5303-11. 2010
    ..This phase I/II trial was conducted to determine the maximum tolerated dose (MTD) and antileukemic effects of (213)Bi-lintuzumab, the first targeted α-emitter, after partially cytoreductive chemotherapy...
  13. ncbi Effect of linear energy transfer (LET) on the complexity of alpha-particle-induced chromosome aberrations in human CD34+ cells
    Rhona M Anderson
    MRC Radiation and Genome Stability Unit, Harwell, Didcot, Oxon, OX11 0RD, United Kingdom
    Radiat Res 167:541-50. 2007
    The aim of this study was to assess the relative influence of the linear energy transfer (LET) of alpha particles on the complexity of chromosome aberrations in the absence of significant other differences in track structure...
  14. pmc Radiation risk to low fluences of alpha particles may be greater than we thought
    H Zhou
    Center for Radiological Research, College of Physicians and Surgeons, and Environmental Health Sciences, School of Public Health, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 98:14410-5. 2001
    ....
  15. ncbi Tumour anti-vascular alpha therapy: a mechanism for the regression of solid tumours in metastatic cancer
    Barry J Allen
    Phys Med Biol 52:L15-9. 2007
    ..This effect depends on the expression of targeted receptors by capillary pericytes and contiguous cancer cells, and on the short-range and high-energy transfer of alpha radiation...
  16. pmc Mitochondrial function and nuclear factor-kappaB-mediated signaling in radiation-induced bystander effects
    Hongning Zhou
    Center for Radiological Research, College of Physicians and Surgeons, Mailman School of Public Health, Columbia University, New York, NY, USA
    Cancer Res 68:2233-40. 2008
    ....
  17. ncbi HPRT mutants induced in bystander cells by very low fluences of alpha particles result primarily from point mutations
    L Huo
    Department of Cancer Cell Biology, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Radiat Res 156:521-5. 2001
    ..5 or 10 cGy of alpha-particle radiation (0, 3% or 44%, respectively, of nuclei traversed by one or more alpha particles) were examined...
  18. ncbi Induction and quantification of gamma-H2AX foci following low and high LET-irradiation
    Emma L Leatherbarrow
    DNA Damage Group, Radiation and Genome Stability Unit, Medical Research Council, Harwell, Oxfordshire, UK
    Int J Radiat Biol 82:111-8. 2006
    ....
  19. ncbi First clinical experience with alpha-emitting radium-223 in the treatment of skeletal metastases
    Sten Nilsson
    Radiumhemmet, The Karolinska Hospital and Institute, Stockholm, Sweden
    Clin Cancer Res 11:4451-9. 2005
    ..The main goals were to study the safety and tolerability of the alpha-emitter radium-223 (223Ra) in breast and prostate cancer patients with skeletal metastases. In addition, pain palliation was evaluated...
  20. ncbi MIRD Pamphlet No. 22 (abridged): radiobiology and dosimetry of alpha-particle emitters for targeted radionuclide therapy
    George Sgouros
    Department of Radiology and Radiological Science, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21231, USA
    J Nucl Med 51:311-28. 2010
    ..The objective of this work is to review those aspects of the field that are pertinent to targeted alpha-particle emitter therapy and to provide guidance and recommendations for human alpha-particle emitter dosimetry...
  21. pmc Comparison of RBE values of high-LET α-particles for the induction of DNA-DSBs, chromosome aberrations and cell reproductive death
    Nicolaas A P Franken
    Department of Radiation Oncology, Laboratory for Experimental Oncology and Radiobiology, Centre for Experimental Molecular Medicine, University of Amsterdam, Amsterdam, The Netherlands
    Radiat Oncol 6:64. 2011
    ..Relevant information on RBE values might be derived from studies on cells in culture...
  22. ncbi Tumor therapy with targeted atomic nanogenerators
    M R McDevitt
    Molecular Pharmacology and Therapeutics Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Science 294:1537-40. 2001
    ..Nanogenerators targeting a wide variety of cancers may be possible...
  23. ncbi Targeted alpha particle immunotherapy for myeloid leukemia
    Joseph G Jurcic
    Department of Medicine, Memorial Sloan Kettering Cancer Center and Weill Medical College of Cornell University, New York, NY 10021, USA
    Blood 100:1233-9. 2002
    ..This study demonstrates the safety, feasibility, and antileukemic effects of (213)Bi-HuM195, and it is the first proof-of-concept for systemic targeted alpha particle immunotherapy in humans...
  24. ncbi Expression of CONNEXIN43 is highly sensitive to ionizing radiation and other environmental stresses
    Edouard I Azzam
    Laboratory of Radiobiology, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Cancer Res 63:7128-35. 2003
    ..In contrast, the response after UV radiation varied and was cell type-dependent. Overall, these data suggest a critical role for genes involved in intercellular communication in mediating the cellular responses to a variety of stresses...
  25. ncbi In vitro and preclinical targeted alpha therapy of human prostate cancer with Bi-213 labeled J591 antibody against the prostate specific membrane antigen
    Y Li
    Centre for Experimental Radiation Oncology, Cancer Care Centre, St George Hospital, Kogarah, NSW, Australia
    Prostate Cancer Prostatic Dis 5:36-46. 2002
    ..Because of its in vitro cytotoxicity and these anti-proliferative properties in vivo, the (213)Bi-J591 conjugate has considerable potential as a new therapeutic agent for the treatment of prostate cancer...
  26. ncbi Importance of receptor density in alpha radioimmunotherapy in B cell malignancies: an in-vitro study
    Katia Vandenbulcke
    Department of Radiopharmacy, Ghent University, Belgium
    Nucl Med Commun 25:1131-6. 2004
    ..The development of RIT with alpha emitters is attractive because of the high linear energy transfer (LET) and short path length, allowing higher tumour cell kill and lower toxicity to healthy tissues...
  27. ncbi Evidence of extranuclear cell sensitivity to alpha-particle radiation using a microdosimetric model. I. Presentation and validation of a microdosimetric model
    N Chouin
    INSERM, U892, Nantes, F 44093 France
    Radiat Res 171:657-63. 2009
    ..Good agreements were also observed with previously published results...
  28. pmc A multi-port low-fluence alpha-particle irradiator: fabrication, testing and benchmark radiobiological studies
    Prasad V S V Neti
    Department of Radiology, Division of Radiation Research, New Jersey Medical School, Newark, New Jersey 07103, USA
    Radiat Res 161:732-8. 2004
    A new multi-port irradiator, designed to facilitate the study of the effects of low fluences of alpha particles on monolayer cultures, has been developed...
  29. pmc A comparitive assessement of cytokine expression in human-derived cell lines exposed to alpha particles and X-rays
    Vinita Chauhan
    Consumer and Clinical Radiation Protection Bureau, Health Canada, Ottawa, ON, Canada
    ScientificWorldJournal 2012:609295. 2012
    ..These results suggest that certain proinflammatory cytokines may be involved in the biological effects related to α- particle exposure and the responses are cell type and radiation type specific...
  30. ncbi Novel approaches with track segment alpha particles and cell co-cultures in studies of bystander effects
    C R Geard
    Radiological Research Accelerator Facility, Center for Radiological Research, College of Physicians and Surgeons of Columbia University, 136 South Broadway, PO Box 21, Irvington, NY 10533, USA
    Radiat Prot Dosimetry 99:233-6. 2002
    ..This procedure allows for a defining of the factors responsible for initiating bystander effects and for determining their quantitative relevance...
  31. ncbi Bismuth-213 and actinium-225 -- generator performance and evolving therapeutic applications of two generator-derived alpha-emitting radioisotopes
    Alfred Morgenstern
    European Commission, Joint Research Centre, Institute for Transuranium Elements, 76125 Karlsruhe, Germany
    Curr Radiopharm 5:221-7. 2012
    ..Selected preclinical studies are highlighted and the current clinical experience with (225)Ac and (213)Bi is summarized...
  32. ncbi No increase in radiation-induced chromosome aberration complexity detected by m-FISH after culture in the presence of 5'-bromodeoxyuridine
    Natalia D Sumption
    MRC Radiation and Genome Stability Unit, Harwell, Didcot, Oxfordshire, OX11 0RD, UK
    Mutat Res 594:30-8. 2006
    ....
  33. ncbi Alpha particles as radiopharmaceuticals in the treatment of bone metastases: mechanism of action of radium-223 chloride (Alpharadin) and radiation protection
    Philippa J Cheetham
    Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center, New York, New York 10032, USA
    Oncology (Williston Park) 26:330-7, 341. 2012
    ..The mechanism of action of Alpharadin and specifics of administration, radiation protection, and patient management will be discussed...
  34. pmc Chromosome damage in human cells by γ rays, α particles and heavy ions: track interactions in basic dose-response relationships
    Bradford D Loucas
    Department of Radiation Oncology, The University of Texas Medical Branch, Galveston, Texas 77555, USA
    Radiat Res 179:9-20. 2013
    ..While such track interaction had been previously theorized, to the best of our knowledge, it has never been demonstrated experimentally...
  35. ncbi Gene expression profile of human lymphocytes exposed to (211)At alpha particles
    A Turtoi
    Forschungszentrum Julich, Department of Safety and Radiation Protection, Germany
    Radiat Res 174:125-36. 2010
    ..78 MeV mean energy alpha particles from extracellular (211)At. Lymphocytes were exposed to fluences of 0.3-9...
  36. ncbi The relationship between the RBE of alpha particles and the radiosensitivity of different mutations of Chinese hamster cells
    N A Zyuzikov
    Department of Radiation Biology, St. Bartholomew's and the Royal London School of Medicine and Dentistry, UK
    Radiat Environ Biophys 40:243-8. 2001
    ..Since cells with different defects of repair or cell cycle control have different radiosensitivities, we conclude that the effects of x-ray irradiation and the RBE are mostly determined by the activity of repair processes...
  37. ncbi The sensitivity of the alkaline comet assay in detecting DNA lesions induced by X rays, gamma rays and alpha particles
    U Rössler
    Federal Office for Radiation Protection, Department Radiation Protection and Health, Ingolstadter Landstrasse 1, 85764 Oberschleissheim, Germany
    Radiat Prot Dosimetry 122:154-9. 2006
    ..02 Gy for Am-241 and depicte a higher biological effectiveness. These results indicate that differences in biological effects arise through downstream processing of complex DNA damage...
  38. ncbi Characterisation of a setup for mixed beam exposures of cells to 241Am alpha particles and X-rays
    Elina Staaf
    Centre for Radiation Protection Research, GMT Department, Stockholm University, Svante Arrhenius väg 20C, 106 91 Stockholm, Sweden
    Radiat Prot Dosimetry 151:570-9. 2012
    ..The authors have constructed a facility where cells can be simultaneously exposed to (241)Am alpha particles and 190-kV X-rays at 37°C...
  39. ncbi Comparative cellular catabolism and retention of astatine-, bismuth-, and lead-radiolabeled internalizing monoclonal antibody
    Z Yao
    Department of Nuclear Medicine, Warren G. Magnuson Clinical Center, National Institutes of Health, 10 Center Dr, Bethesda, MD 20892-1180, USA
    J Nucl Med 42:1538-44. 2001
    ..These catabolism differences may be important in the selection of alpha-radionuclides for radioimmunotherapy...
  40. pmc Alpha particles induce apoptosis through the sphingomyelin pathway
    Jonathan H Seideman
    a Memorial Sloan Kettering Cancer Center, Department of Chemistry and Molecular Pharmacology, New York, New York 10065
    Radiat Res 176:434-46. 2011
    ..These data indicate that α particles can activate the sphingomyelin pathway to induce apoptosis...
  41. ncbi Radioimmunotherapy with alpha-particle emitting radionuclides
    M R Zalutsky
    Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA
    Q J Nucl Med Mol Imaging 48:289-96. 2004
    ..The current status of preclinical and clinical research with antibodies labeled with 3 promising alpha-particle emitting radionuclides - (213)Bi, (225)Ac, and (211)At - also will be summarized...
  42. ncbi Clinical trials of targeted alpha therapy for cancer
    Barry J Allen
    Centre for Experimental Radiation Oncology, St George Hospital, Gray St Kogarah NSW 2217, Australia
    Rev Recent Clin Trials 3:185-91. 2008
    ..Results of past and current trials are reviewed, and the bases of some proposed trials are presented...
  43. pmc A new mechanism for DNA alterations induced by alpha particles such as those emitted by radon and radon progeny
    B E Lehnert
    Life Sciences Division, Los Alamos National Laboratory, New Mexico 87545, USA
    Environ Health Perspect 105:1095-101. 1997
    ..How transmissible factors like those observed here in vitro may extend to the in vivo condition in the context of a-particle-induced carcinogenesis in the respiratory tract remains to be determined...
  44. ncbi Alpha-particles for targeted therapy
    George Sgouros
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, School of Medicine, Baltimore MD USA
    Adv Drug Deliv Rev 60:1402-6. 2008
    ..Results from the small number of clinical trials reported to date have shown efficacy without significant toxicity...
  45. pmc Radiofungicidal effects of external gamma radiation and antibody-targeted beta and alpha radiation on Cryptococcus neoformans
    Ruth A Bryan
    Department of Nuclear Medicine, Joint Research Centre, Institute for Transuranium Elements, Karlsruhe, Germany
    Antimicrob Agents Chemother 52:2232-5. 2008
    ..binding) of Cryptococcus neoformans cells subjected to gamma rays from an external source, and beta and alpha particles delivered to fungal cells by capsule-specific antibody...
  46. ncbi A comparison of cellular irradiation techniques with alpha particles using the Geant4 Monte Carlo simulation toolkit
    S Incerti
    Centre d Etudes Nucléaires de Bordeaux Gradignan, CNRS IN2P3, Universite Bordeaux 1, Le Haut Vigneau, Gradignan Cedex, France
    Radiat Prot Dosimetry 122:327-9. 2006
    ..The simulation allows the calculation of hit distributions among the cellular population as well as the absorbed dose for two typical cellular geometries...
  47. ncbi Induction of linear tracks of DNA double-strand breaks by alpha-particle irradiation of cells
    Jan Stap
    Center for Microscopical Research, Department of Cell Biology and Histology, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Nat Methods 5:261-6. 2008
    ..of easily recognizable linear arrays of DSBs in nuclei of adherent eukaryotic cells by exposing the cells to alpha particles from a small Americium source (Box 1)...
  48. ncbi Development and characterization of an in vitro alpha radiation exposure system
    Lindsay A Beaton
    Department of Physics, Carleton University, Ottawa, ON, Canada
    Phys Med Biol 56:3645-58. 2011
    ..steel discs with activities averaging 66 kBq and Mylar-based culture dishes to allow the transmission of alpha particles. The dosimetry of the exposure system was calculated using the GEANT4 Monte Carlo simulation toolkit with the ..
  49. ncbi Domestic radon risks may be dominated by bystander effects--but the risks are unlikely to be greater than we thought
    D J Brenner
    Center for Radiological Research, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Health Phys 85:103-8. 2003
    Radon risks derive from exposure of bronchio-epithelial cells to alpha particles. Alpha-particle exposure can result in bystander effects when irradiated cells emit signals resulting in damage to nearby unirradiated bystander cells...
  50. ncbi Double strand break rejoining after irradiation of human fibroblasts with X rays or alpha particles: PFGE studies and numerical models
    M Pinto
    Gray Cancer Institute, PO Box 100, Mount Vernon Hospital, Northwood, Middlesex HA6 2JR, UK
    Radiat Prot Dosimetry 99:133-6. 2002
    ..of DNA double strand breaks (DSBs) induced in primary human fibroblasts by 240 kVp X rays and 238Pu alpha particles (110 keV.micron-1) were resolved using pulsed-field gel electrophoresis (PFGE)...
  51. ncbi Low doses of alpha particles do not induce sister chromatid exchanges in bystander Chinese hamster cells defective in homologous recombination
    Hatsumi Nagasawa
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA
    DNA Repair (Amst) 7:515-22. 2008
    ..Furthermore, when irradiated with very low doses of alpha particles, SCEs were not induced in irs3 cells, as compared to a prominent bystander effect observed in V79 cells [H...
  52. ncbi Dose responses for chromosome aberrations produced in noncycling primary human fibroblasts by alpha particles, and by gamma rays delivered at sublimiting low dose rates
    Michael N Cornforth
    Departments of Radiation Oncology and Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas 77555 0656, USA
    Radiat Res 158:43-53. 2002
    ..Exposure to (238)Pu alpha particles also produced a linear dose response for total aberrations, whose slope-with respect to (137)Cs gamma rays as ..
  53. ncbi The role of promotion in carcinogenesis from protracted high-LET exposure
    S B Curtis
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Phys Med 17:157-60. 2001
    ..is suggested that the effect might be caused by a 'Bystander Effect' by which normal cells in the vicinity of initiated cells are hit by alpha particles and send out signals that modify the cell kinetics of the already-initiated clones.
  54. ncbi Lack of detectable transmissible chromosomal instability after in vivo or in vitro exposure of mouse bone marrow cells to 224Ra alpha particles
    S D Bouffler
    Radiation Effects Department, National Radiological Protection Board, Chilton, Didcot, Oxfordshire, OX11 0RQ, United Kingdom
    Radiat Res 155:345-52. 2001
    ..These findings emphasize the sensitivity of murine hemopoietic tissue to experimental manipulation and reinforce the importance of appropriate concurrent control experiments in any investigation of transmissible genomic instability...
  55. ncbi Comparison of different classes of radionuclides for potential use in radioimmunotherapy
    Tom C Karagiannis
    Trescowthick Research Laboratories, Peter MacCallum Cancer Centre, Melbourne, Australia
    Hell J Nucl Med 10:82-8. 2007
    ..The aim of this article is to discuss the different classes of radionuclides with potential for clinical use in radioimmunotherapy...
  56. ncbi Gene expression profiles in mouse liver cells after exposure to different types of radiation
    Mehryar Habibi Roudkenar
    Department of Pathology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    J Radiat Res 49:29-40. 2008
    ..Anti-inflammatory treatment could be helpful for the prevention and protection of radiation-induced hepatic injury...
  57. ncbi Detection of chromosomal instability in alpha-irradiated and bystander human fibroblasts
    Brian Ponnaiya
    Radiological Research Facility, Center for Radiological Research, Columbia University, 136 S Broadway, P O Box 21, Irvington, NY 10533, USA
    Mutat Res 568:41-8. 2004
    ..The results presented here support the link between the radiation-induced phenomena of genomic instability and the bystander effect...
  58. ncbi Bystander effect for chromosomal aberrations induced in wild-type and repair deficient CHO cells by low fluences of alpha particles
    Hatsumi Nagasawa
    Department of Cancer Cell Biology, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Mutat Res 508:121-9. 2002
    We have previously shown that when confluent cultures of mammalian cells are exposed to very low fluences of alpha particles, fluences whereby as few as 1% of the cell nuclei are traversed by a single particle, genetic effects including ..
  59. ncbi Extracellular factor(s) following exposure to alpha particles can cause sister chromatid exchanges in normal human cells
    B E Lehnert
    Cell and Molecular Biology Group, Life Sciences Division, Los Alamos National Laboratory, New Mexico 87545, USA
    Cancer Res 57:2164-71. 1997
    The mechanism(s) by which alpha particles like those emitted from inhaled radon and radon progeny cause their mutagenic and carcinogenic effects remains unclear...
  60. pmc Mutagenic effects of a single and an exact number of alpha particles in mammalian cells
    T K Hei
    Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 94:3765-70. 1997
    ..spectrum of S1- mutants induced in human-hamster hybrid (A(L)) cells by either a single or an exact number of alpha particles. Exponentially growing cells were stained briefly with a nontoxic concentration of Hoechst dye for image ..
  61. ncbi Vascular-targeted radioimmunotherapy with the alpha-particle emitter 211At
    S J Kennel
    Life Sciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, USA
    Radiat Res 157:633-41. 2002
    ..Work in this model system demonstrates that vascular targeting of alpha-particle emitters is an efficient therapy for small perivascular tumors and may be applicable to human disease when specific targeting agents are identified...
  62. ncbi Biochemical alterations in human cells irradiated with alpha particles delivered by macro- or microbeams
    Nathalie Gault
    Commissariat a l Energie Atomique, Direction des Sciences du Vivant, Département de Radiobiologie Radiopathologie, 92265 Fontenay aux Roses, France
    Radiat Res 167:551-62. 2007
    ..irradiation and compared biochemical changes and DNA damage after targeted and nontargeted irradiation with alpha particles delivered by macro- or microbeams, using gamma radiation as a reference...
  63. ncbi Membrane-dependent bystander effect contributes to amplification of the response to alpha-particle irradiation in targeted and nontargeted cells
    Maité Hanot
    CEA, IRAMIS, SIS2M, F 91191 Gif sur Yvette, France
    Int J Radiat Oncol Biol Phys 75:1247-53. 2009
    ..Free radicals are believed to play an active role in the bystander response. This study investigated their origin as well as their temporal and spatial impacts in the bystander effect...
  64. ncbi Monte Carlo calculation of the maximum therapeutic gain of tumor antivascular alpha therapy
    Chen Yu Huang
    University of New South Wales, Kogarah, New South Wales, Australia
    Med Phys 39:1282-8. 2012
    ..The purpose of this paper is to quantitatively analyze the therapeutic efficacy and safety of TAVAT by building up the testing Monte Carlo microdosimetric models...
  65. ncbi Radioimmunotherapy with alpha-particle emitters: microdosimetry of cells with a heterogeneous antigen expression and with various diameters of cells and nuclei
    Y Kvinnsland
    Department of Nuclear Medicine, The Norwegian Radium Hospital, 0310, Norway
    Radiat Res 155:288-96. 2001
    ..The magnitudes of the differences were found to be a function of the fractions of mean specific energy delivered by surrounding activity and by activity bound to the cells...
  66. ncbi Monte-Carlo dosimetry on a realistic cell monolayer geometry exposed to alpha particles
    Ph Barberet
    Universite Bordeaux, CENBG, UMR 5797, F 33170 Gradignan, France
    Phys Med Biol 57:2189-207. 2012
    ..The methodology presented in this paper provides microdosimetric quantities calculated from realistic cellular volumes. It is based on open-source oriented software that is publicly available...
  67. ncbi Alpha-particle emitting atomic generator (Actinium-225)-labeled trastuzumab (herceptin) targeting of breast cancer spheroids: efficacy versus HER2/neu expression
    Ase M Ballangrud
    Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Clin Cancer Res 10:4489-97. 2004
    ..225)Ac has a 10-day half-life and a decay scheme yielding four alpha-particles...
  68. ncbi Efforts to control the errant products of a targeted in vivo generator
    Jaspreet Singh Jaggi
    Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer Res 65:4888-95. 2005
    ..0001). Metal chelation, diuresis with furosemide or chlorothiazide, and competitive metal blockade may be used as adjuvant therapies to modify the renal accumulation of 225Ac daughters...
  69. ncbi Micronuclei in human peripheral blood lymphocytes exposed to mixed beams of X-rays and alpha particles
    Elina Staaf
    Stockholms universitet, Svante Arrhenius väg 20C, 10691 Stockholm, Sweden
    Radiat Environ Biophys 51:283-93. 2012
    ..was to analyse the cytogenetic effect of exposing human peripheral blood lymphocytes (PBL) to a mixed beam of alpha particles and X-rays...
  70. ncbi Delivery of the alpha-emitting radioisotope bismuth-213 to solid tumors via single-chain Fv and diabody molecules
    G P Adams
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Nucl Med Biol 27:339-46. 2000
    ..46) indicating that antigen-specific targeting was not a factor. This suggests that the physical half-life of (213)Bi may be too brief to be effectively paired with systemically-administered diabody or scFv molecules...
  71. ncbi Vascular targeted endoradiotherapy of tumors using alpha-particle-emitting compounds: theoretical analysis
    Gamal Akabani
    Department of Radiology, Duke University Medical Center, Box 3808, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 54:1259-75. 2002
    ..To establish the theoretical framework and study the feasibility of (211)At-labeled anti-tenascin chimeric 81C6 monoclonal antibody (mAb) as anti-vascular endoradiotherapy for the treatment of glioblastoma multiforme (GBM) tumors...
  72. ncbi Renal tubulointerstitial changes after internal irradiation with alpha-particle-emitting actinium daughters
    Jaspreet Singh Jaggi
    Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Am Soc Nephrol 16:2677-89. 2005
    ..These findings are dissimilar to those seen after gamma or beta irradiation of kidneys...
  73. ncbi Targeted alpha therapy: evidence for potential efficacy of alpha-immunoconjugates in the management of micrometastatic cancer
    B J Allen
    Centre for Experimental Radiation Oncology, St George Cancer Care Centre, Kogarah, New South Wales, Australia
    Australas Radiol 43:480-6. 1999
    ..and because their cytotoxicity is the result of their high rate of energy loss and short range of the alpha particles. These radionuclides have properties that are particularly suited for the elimination of single cells in ..
  74. ncbi The early and initiation processes of radiation-induced bystander effects involved in the induction of DNA double strand breaks in non-irradiated cultures
    W Han
    Key Laboratory of Ion Beam Bioengineering, Institute of Plasma Physics, Chinese Academy of Sciences, Hefei, Anhui 230031, People s Republic of China
    Br J Radiol 80:S7-12. 2007
    ..might be involved in these processes...
  75. ncbi Studies of bystander effects in human fibroblasts using a charged particle microbeam
    K M Prise
    Gray Laboratory Cancer Research Trust, Mount Vernon Hospital, Northwood, Middlesex, UK
    Int J Radiat Biol 74:793-8. 1998
    ..To determine the role of cell-to-cell mediated effects in the response of cells to different radiations by using a charged particle microbeam capable of targeting individual cells with counted particles...
  76. ncbi Ac-225 and her daughters: the many faces of Shiva
    M R McDevitt
    Cell Death Differ 9:593-4. 2002
  77. ncbi 211At radioimmunotherapy of subcutaneous human ovarian cancer xenografts: evaluation of relative biologic effectiveness of an alpha-emitter in vivo
    Tom Bäck
    Department of Radiation Physics, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    J Nucl Med 46:2061-7. 2005
    ..This study was performed to evaluate the relative biological effectiveness (RBE) of 211At compared with that of 60Co gamma-irradiation in an RIT model. Our endpoint was growth inhibition (GI) of subcutaneous xenografts...
  78. ncbi Gross alpha and beta activity analysis in water--a routine laboratory method using liquid scintillation analysis
    Ross I Kleinschmidt
    Queensland Health Scientific Services, P O Box 594 Archerfield, QD 4108, Australia
    Appl Radiat Isot 61:333-8. 2004
    ..The results show that the LSA method exceeds performance of the ISO methods in measurement accuracy...
  79. ncbi Cell death triggered by alpha-emitting 213Bi-immunoconjugates in HSC45-M2 gastric cancer cells is different from apoptotic cell death
    Christof Seidl
    Department of Nuclear Medicine, Technische Universitat Munchen, Ismaninger Strasse 22, 81675, Munich, Germany
    Eur J Nucl Med Mol Imaging 32:274-85. 2005
    ..The aim of this study was to investigate cellular damage and the mode of cell death triggered by 213Bi-immunoconjugates...
  80. ncbi A comparison of high- versus low-linear energy transfer somatostatin receptor targeted radionuclide therapy in vitro
    Tapan Nayak
    Radiopharmaceutical Sciences Program, College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, NM 87131 0001, USA
    Cancer Biother Radiopharm 20:52-7. 2005
    ..The somatostatin analog [DOTA(0)-Tyr(3)]-octreotide (DOTATOC) has been widely used to target somatostatin receptor expressing tumors for therapy using radionuclides such as (90)Y or (177)Lu...
  81. ncbi Production and validation of CR-39-based dishes for alpha-particle radiobiological experiments
    Sylvain Gaillard
    Laboratoire de Microanalyses Nucleaires, UFR Sciences et Techniques, Universite de Franche Comte, 25030 Besancon Cedex, France
    Radiat Res 163:343-50. 2005
    The study of radiobiological effects induced in vitro by low fluences of alpha particles would be significantly enhanced if the precise localization of each particle track in the cell monolayer was known...
  82. ncbi Measuring method of undamaged samples for the radiation levels of decorative building materials
    Mao Yahong
    Physics and Electronics Department, University of Electronic Science and Technology of China, Chendu 610054, China
    Health Phys 87:75-8. 2004
    ..The surface alpha ray flux of materials cannot be used to estimate the internal and external exposure indexes of color-glazed tiles...
  83. ncbi Microdosimetry of inhomogeneous radon progeny distributions in bronchial airways
    H Fakir
    Institut de Radioprotection et de Surete Nucleaire, DRPH SDI, B P no 17, F 92262 Fontenay aux Roses Cedex, France
    Radiat Prot Dosimetry 113:129-39. 2005
    A Monte Carlo code, initially developed for the calculation of microdosimetric spectra for alpha particles in cylindrical airways, has been extended to allow the computation (i) of additional microdosimetric parameters and (ii) for ..
  84. ncbi Effect of a grounded object on radon measurement using AlphaGUARD
    Hirokazu Ichitsubo
    Radon Research Group, Research Center for Radiation Safety, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage, Chiba 263 8555, Japan
    Health Phys 87:79-81. 2004
    ..When the connector is grounded, the radon concentration is again falsely measured as 0 Bq m. If the nozzle or connector is ungrounded, the AlphaGUARD measures radon concentration accurately. Health Phys...
  85. ncbi A microbeam study of DNA double-strand breaks in bystander primary human fibroblasts
    L B Smilenov
    Center for Radiological Research, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Radiat Prot Dosimetry 122:256-9. 2006
    ..Utilising the Columbia University single-cell microbeam system to deliver 2 or 20 individual alpha particles to selected cell nuclei in a precisely known proportion of cells in a population, the induced DNA DSB ..
  86. ncbi Bound PCNA in nuclei of primary rat tracheal epithelial cells after exposure to very low doses of plutonium-238 alpha particles
    M A Hill
    Medical Research Council, Radiation and Genome Stability Unit, Harwell, Oxfordshire, OX11 0RD, United Kingdom
    Radiat Res 163:36-44. 2005
    ..Examination by immunofluorescence techniques of tracheal cell cultures after exposure to very low doses of alpha particles revealed a large proportion of cells with proliferating cell nuclear antigen (PCNA) bound in their nuclei...
  87. ncbi The influence of radiation quality on radiation-induced hemolysis and hemoglobin oxidation of human erythrocytes
    Mieczysław Puchała
    Department of Molecular Biophysics, University of Łódź, Poland
    J Radiat Res 45:275-9. 2004
    ..These results are interpreted by proposing that OH-radicals, whose yields are smaller with densely ionizing radiation, play a crucial role in the induction of the processes for radiation-induced erythrocyte damage...
  88. ncbi Pretargeted alpha emitting radioimmunotherapy using (213)Bi 1,4,7,10-tetraazacyclododecane-N,N',N",N"'-tetraacetic acid-biotin
    Zhengsheng Yao
    Department of Nuclear Medicine, Warren G Magnuson Clinical Center, NIH, Bethesda, Maryland 20892, USA
    Clin Cancer Res 10:3137-46. 2004
    ..This study investigated the biodistribution of bismuth-labeled biotin in A431 tumor-bearing mice pretargeted with antibody B3-streptavidin (B3-SA) and examined the therapeutic efficacy of the alpha emitter, (213)Bi-labeled biotin...
  89. ncbi Microdosimetry of radon progeny alpha particles in bronchial airway bifurcations
    H Fakir
    Division of Physics and Biophysics, Department of Molecular Biology, University of Salzburg, Hellbrunner Strasse 34, A 5020 Salzburg, Austria
    Radiat Prot Dosimetry 117:382-94. 2005
    A Monte Carlo code, initially developed for the calculation of microdosimetric spectra for alpha particles in cylindrical airways, has been extended to allow the computation of microdosimetric parameters for multiple source-target ..
  90. ncbi Alpha-particle Monte Carlo simulation for microdosimetric calculations using a commercial spreadsheet
    John C Roeske
    Department of Radiation and Cellular Oncology, University of Chicago, 5758 S Maryland Ave, MC 9006, Chicago, IL 60637, USA
    Phys Med Biol 52:1909-22. 2007
    ..Thus, the spreadsheet Monte Carlo method represents a simple and efficient method to calculate single-event spectra for alpha-particle emitters. Copies of the spreadsheet are available from the corresponding author upon request...
  91. ncbi Simple experimental method for alpha particle range determination in lead iodide films
    Yuri Dmitriev
    Radiation Monitoring Devices Inc, Watertown, MA 02472, USA
    Rev Sci Instrum 78:053907. 2007
    An experimental method for determining the range of alpha particles in films based on I-V(s) analysis has been suggested. The range of 5...
  92. ncbi Incorporation of microdosimetric concepts into a biologically-based model of radiation carcinogenesis
    H Fakir
    Division of Physics and Biophysics, Department of Molecular Biology, University of Salzburg, Hellbrunner Strasse 34, A 5020 Salzburg, Austria
    Radiat Prot Dosimetry 122:330-4. 2006
    ..Such an approach allows the consideration of hit frequencies and the variability of the specific energy and LET spectra of radon progeny alpha particles in bronchial target cells for different exposure conditions.
  93. ncbi [Alpha-radioimmunotherapy: a review of recent developments]
    S Supiot
    Service de Radiotherapie, Centre Rene Gauducheau, Boulevard Jacques Monod, 44800 Nantes Saint Herblain, France
    Cancer Radiother 11:252-9. 2007
    ..This review aims at presenting recent advances of this therapeutic approach, and at detailing the biological specificities of this kind of radiation...
  94. ncbi Simulation of the measured ionisation-cluster distributions of alpha-particles in nanometric volumes of propane
    L De Nardo
    INFN Laboratori Nazionali di Legnaro, Viale dell Universita 2, I 35020 Legnaro, Padova, Italy
    Radiat Prot Dosimetry 122:427-31. 2006
    In the last years, the probability of the formation of ionisation clusters by primary alpha particles at 5.4 MeV in nanometric volumes of propane (20.6 and 24.0 nm in a material of density 1...
  95. ncbi Effects of low and high LET radiations on bystander human lung fibroblast cell survival
    Rajamanickam Baskar
    Center for Radiological Research, Department of Radiation Oncology, College of Physicians and Surgeons, Columbia University, New York, USA
    Int J Radiat Biol 83:551-9. 2007
    ....
  96. ncbi The distribution of the number of alpha hits per target cell: a new parameter to improve risk assessment for cancer induction using ICRP models
    P Fritsch
    Laboratoire de Radiotoxicologie, SRCA DRR DSV CEA, BP 12, 91680 Bruyères le Châtel, France
    Radiat Prot Dosimetry 127:46-9. 2007
    ..This underlines the uncertainties in risk assessment associated with a dose rate effect...
  97. ncbi Design, spectrum measurements and simulations for a 238Pu alpha-particle irradiator for bystander effect and genomic instability experiments
    Arvi Hakanen
    STUK Radiation and Nuclear Safety Authority P O Box 14, FIN 00881 Helsinki, Finland
    Appl Radiat Isot 64:864-7. 2006
    ..Mean energies and full-widths at half-maximum (FWHM) were calculated for the three different helium gas tracks...
  98. ncbi Optical excitation of LiF:Mg,Ti following alpha and beta irradiation
    Y S Horowitz
    Physics Department, Ben Gurion University, Beer Sheva 84105, Israel
    Radiat Prot Dosimetry 119:386-9. 2006
    ....
  99. ncbi Choosing an alpha radiation weighting factor for doses to non-human biota
    Douglas B Chambers
    SENES Consultants Limited, 121 Granton Drive, Unit 12, Richmond Hill, Ontario L4B 3N4, Canada
    J Environ Radioact 87:1-14. 2006
    ..The relevancy of each experimental result in selecting a radiation weighting factor for doses from alpha particles in biota was judged on the basis of criteria established a priori...
  100. ncbi A composite microdose Adaptive Response (AR) and Bystander Effect (BE) model-application to low LET and high LET AR and BE data
    Bobby E Leonard
    International Academy, 693 Wellerburn Road, Severna Park, Maryland 21146, USA
    Int J Radiat Biol 84:681-701. 2008
    ....
  101. ncbi Innovative procedure for the determination of gross-alpha/gross-beta activities in drinking water
    S Wisser
    Rhine Main Water Research Ltd, Kurfürstenstr 6, D 65203 Wiesbaden, Germany
    Appl Radiat Isot 64:368-72. 2006
    ..The limits of detection for gross-alpha and gross-beta activity are in the range 25-210 mBq/l, respectively, for a measurement time of only 8-9 h...

Research Grants49

  1. Targeting alpha particle-emitting radionuclides to the nuclei of cancer cells
    Thomas Quinn; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  2. Cancer Mortality among Military Participants at U.S. Nuclear Weapons Tests
    JOHN DUNNING BOICE; Fiscal Year: 2013
    ..Ground between 1946 and 1958 could have been exposed to various types of radiation including gamma rays, alpha particles and intakes of radioactive substances such as plutonium, uranium and fallout products...
  3. Novel Receptor-Targeting Theranostic Peptides for Prostate Cancer
    Yubin Miao; Fiscal Year: 2013
    ....
  4. Targeted therapy of pancreatic cancer with in vivo radionuclide generator
    Ekaterina Dadachova; Fiscal Year: 2012
    ..If successful, this approach offers the possibility of cure for PCa. ..
  5. Peptide-targeted alpha-particle emitting phage for ovarian cancer therapy.
    Thomas P Quinn; Fiscal Year: 2013
    ..b>Alpha particles are helium 4He ions that result in high linear energy transfer (LET) upon emission, significantly higher than ..
  6. Improving therapy of glioblastoma multiforme by enhancing therapeutic drug delive
    Michael R McDevitt; Fiscal Year: 2013
    ..in GBM;locally irradiate those vessels and the adjacent perivascular cancer stem cell niche with cytotoxic alpha particles;and favorably remodel the vascular endothelium and improve subsequent chemotherapy...
  7. Protection against radiation-induced damage to intestinal nutrient transport
    Roger Howell; Fiscal Year: 2009
    ..Three sources of radiation will be used in each aim: acute 137Cs gamma rays, chronic 137Cs gamma rays, and alpha particles from 210Po. We have found that vitamins mitigate biological effects of low- and high-LET radiation in testes...
  8. INORGANIC ION EXCHANGERS FOR 213BI GENERATORS
    Paul Sylvester; Fiscal Year: 1999
    ..By contrast, alpha particles are thousands of times more efficient at destroying cancer cells and have a range of only a few mu m, ..
  9. Cytoplasmic Damage and Genotoxicity
    Tom K Hei; Fiscal Year: 2013
    ..A state of the art charge particle microbeam that can deliver a precise number of alpha particles with a beam size of ~ 1 micrometer and a precision greater than 98% provides an unprecedented opportunity to ..
  10. BYSTANDER EFFECTS OF LOW DOSE ALPHA PARTICLES
    Bruce Lehnert; Fiscal Year: 2001
    ..of the process may involve the induction of mechanisms in cells that do not receive direct exposure to alpha particles. These so called "bystander effects" can be mediated via fluid-phase, extracellular factors and, perhaps, ..
  11. RADON, BRONCHIAL MORPHOMETRY, AND OCCUPATIONAL HEALTH
    David Brenner; Fiscal Year: 1993
    ..in smokers and non smokers, to estimate the energy deposition characteristics of the radon-daughter alpha particles, in the cells at risk in the bronchial epithelia of miners and the general public; 3) combine the data from (..
  12. RECEPTOR MEDIATED RADIATION ONCOLOGY
    WILLIAM BLOOMER; Fiscal Year: 1991
    ..on the possibility of using the radiotoxicity of Auger and alpha emitters for cancer treatment; in the field of cellular and molecular radiation biology, the emphasis is on the mechanism of action of alpha particles and the Auger effect.
  13. IMAGING OF BORON IN TISSUE AT CELLULAR LEVEL FOR BNCT
    TOM WHITAKER; Fiscal Year: 1991
    ..Since the ranges of the alpha particles and lithium ions that result from the capture are very short (mum), the clinical efficacy is only guaranteed ..
  14. ROLES OF HUMAN RECOMBINATION GENES IN GENOME INSTABILITY
    David Chen; Fiscal Year: 2001
    ..Limited studies with alpha particles have also suggested that high linear energy transfer (LET) radiation is more potent than low LET gamma rays ..
  15. MELANOMA RADIOTHERAPY- PEPTIDE TARGETED ALPHA-RADIATION
    Thomas Quinn; Fiscal Year: 2000
    ..proposed commercial application: not available ..
  16. Chelator for a Therapeutic Ra-223 Radiopharmaceutical
    TERESIA MOLLER; Fiscal Year: 2004
    ..The high linear energy transfer (LET) and relatively short penetration range (a few cell diameters) makes alpha particles particularly attractive for the treatment of micro tumors...
  17. Melanoma Therapy via peptide targeted alpha-radiation
    Thomas Quinn; Fiscal Year: 2004
    ..DOTA]-ReCCMSH targeting of Alpha-particle emitting radiation to melanoma tumors in patients with metastatic disease. ..
  18. CANCER INCIDENCE IN URANIUM MINERS EXPOSED TO RADON
    Radim Sram; Fiscal Year: 1999
    ....
  19. RADIATION, CHROMOSOMAL ABERRATIONS, AND RELATIVE BIOLOGI
    Joel Bedford; Fiscal Year: 2002
    ..This would be studied by comparing the induction of exchange aberrations after exposing cells to 5 MeV alpha particles with that from damage after decay of 125IUdR incorporated into DNA...
  20. RADON PROGENY LUNG DOSE MONITOR
    HARVEL WRIGHT; Fiscal Year: 1991
    ..within the human respiratory tract and an alpha particle spectrometer to detect and measure the energy of alpha particles that would be produced by these radon progeny...
  21. ZINC SULFIDE AS A SPECT SCINTILLATOR
    Brian Fitzpatrick; Fiscal Year: 1992
    ..has long been known as an efficient scintillator: it was used in powder form by Rutherford for detection of alpha particles and continues to be used for that purpose...
  22. CYTOGENETIC EFFECTS PERTAINING TO LOW DOSES OF RADIATION
    Michael Cornforth; Fiscal Year: 1991
    ..This would allow the accurate measurement of radiation-induced chromosome breaks caused by doses well below 10 rad...
  23. Molecular Cages for Alpha Particle Radioimmunotherapy
    MICHAEL DIENER; Fiscal Year: 2002
    ..The development of such a therapy has a potential market of approximately 300,000 Americans/yr. ..
  24. MECHANISMS OF MUTAGENESIS BY SINGLE ALPHA PARTICLES
    TOM HEI; Fiscal Year: 2000
    ..Preliminary data also suggest that irradiation of cellular cytoplasm alone with 4 or more alpha particles induces mutation at the S1 locus at a frequency two fold above the spontaneous level...
  25. MODELING AND DOSIMETRY FOR RADIOLABELED ANTIBODY THERAPY
    George Sgouros; Fiscal Year: 2002
    ....
  26. Targeted Alpha-Particle Emitter Therapy of Metastases
    George Sgouros; Fiscal Year: 2009
    ..The work described in this application is intended to develop and evaluate such an approach. ..
  27. Astatine 211 & Radioiodine Labeled Octreotide Conjugates
    Michael Zalutsky; Fiscal Year: 2004
    ..The proposed in vitro studies include characterization of binding, internalization and catabolism; the proposed in vivo studies include evaluation of tissue distribution, dosimetry, catabolism as well as therapeutic efficacy. ..
  28. ASTATINE AND IODINE RADIOLABELED MONOCLONAL ANTIBODIES
    Michael Zalutsky; Fiscal Year: 2008
    ..abstract_text> ..
  29. High Stability Accelerator for Sub-Cellular Microbeam
    David Brenner; Fiscal Year: 2003
    ..We have considerably more demand for microbeam time than we can cope with, primarily because of limited physicist manpower. ..
  30. RADIOLOGICAL RESEARCH ACCELERATOR FACILITY (RARAF)
    David Brenner; Fiscal Year: 2002
    ..abstract_text> ..
  31. Cancer Risks Attributable To Radiation from Pediatric CT
    David Brenner; Fiscal Year: 2006
    ..The target audiences will be radiologists, pediatricians, family physicians, and the CT industry. We will use telephone interviews supplemented with survey questions, to aid in web content decisions. ..
  32. MECHANISMS OF ARSENIC CARCINOGENESIS
    TOM HEI; Fiscal Year: 2005
    ..abstract_text> ..
  33. HIGH ENERGY IONS AND GENOMIC INSTABILITY
    Eric Hall; Fiscal Year: 2001
    ..human bronchial epithelial cells with a single low dose of high energy (1 GeV/nucleon) iron ions or with alpha particles so that, after in vitro culture for many generations, they become tumorigenic in nude mice...
  34. THE MUTAGENICITY OF MINERAL FIBERS
    TOM HEI; Fiscal Year: 2006
    ..By using specific DNA probes of other genes that have been regionally mapped to various sites on chromosome 11, the molecular spectrum of mutations induced by either asbestos or glass fiber control will be compared. ..
  35. MECHANISMS OF FIBER CARCINOGENESIS
    TOM HEI; Fiscal Year: 2001
    ..Cytogenetic and molecular alterations at the gene level will be analyzed from tumors and intermediate transformation stages to provide a mechanistic basis for tumor induction by mineral fibers. ..
  36. Production of High Specific Activity Lutetium-177
    Cathy Cutler; Fiscal Year: 2005
    ..If impurities are present, develop methods to prevent their introduction or to remove them from the final product. Perform radiolabelling of the Lu-177 produced to molecules of interest in therapeutic applications. ..
  37. Molecular Targeting of EGFR for the Treatment of Gliomas
    ROLF BARTH; Fiscal Year: 2006
    ..second generation drugs BPA and BSH, produce a significant improvement in survival following BNCT compared to that which we have obtained with BSH and BPA in combination, using the F98EGFR and F98EGFRVIII glioma models?" ..
  38. TUMOR SUPPRESSOR GENE METHYLATION IN LUNG ADENOCARCINOMA
    Steven A Belinsky; Fiscal Year: 2010
    ..Transient transfection of minimized promoters into cell lines with an endogenously active or silenced gene will be used to elucidate the sequence of changes involved in repression of promoter activity. REVISED: July 7, 2005 ..
  39. RADIODIAGNOSIS & RADIOTHERAPY OF LUNG CANCER METASTASES
    AMIN KASSIS; Fiscal Year: 2004
    ....
  40. Imaging of O6-Alkylguanine-DNA Alkyltransferase
    Ganesan Vaidyanathan; Fiscal Year: 2005
    ..In summary, this proposal seeks to determine whether the development of a suitable agent for the imaging of tumor AGT will facilitate chemotherapy planning, thereby improving the outcome of alkylator chemotherapy. ..
  41. Gene Methylation and Therapeutic Response in Lung Cancer
    Steven Belinsky; Fiscal Year: 2005
    ..The validation of these genes as biomarkers of lung cancer risk and their detection in sputum and/or serum could ultimately support chemoprevention trials for preventing lung cancer. ..
  42. MARKERS FOR LUNG CARCINOGENESIS IN BRONCHIAL EPITHELIUM
    Steven Belinsky; Fiscal Year: 2001
    ..f., simply markers of exposure) and help identify genetic alterations that are candidate markers of respiratory carcinogenesis. ..
  43. Damage signaling from irradiated to non-irradiated cells
    EDOUARD AZZAM; Fiscal Year: 2004
    ..They are also relevant to diagnostic and therapeutic nuclear medicine where radionuclides are being investigated to detect various diseases and treat cancer. ..
  44. MIBG ANALOGUE RADIOPHARMACEUTICALS
    Ganesan Vaidyanathan; Fiscal Year: 2001
    ..Strategies to augment tumor-to-normal tissue ratios will be investigated. The outcome of this study should help improve the endoradiotherapy of neuroendocrine tumors and possibly of medulloblastoma. ..
  45. TARGETED METAL CHELATORS FOR DIAGNOSTIC IMAGING
    Michael Welch; Fiscal Year: 2001
    ..The synthesis characterization and physicochemical studies will be carried out at Texas A&M University while the in vitro and in vivo evaluation of the pharmaceutical preparations will be undertaken at Washington University. ..
  46. GENETIC/ CYTOGENETIC INSTABILITY OF IONIZING RADIATION
    Michael Cornforth; Fiscal Year: 2002
    ....
  47. RADIOIMMUNOTHERAPY OF B CELL LYMPHOMA WITH ANTI CD74
    M Mattes; Fiscal Year: 2002
    ..This study may lead to the development of more effective radio-conjugates for the therapy of cancer and other diseases. Also, it will provide basic information about the toxic effects of intracellular (really lysosomal) radionuclides. ..
  48. Regulation of BCL-2 and Tumorigenicity
    Marc Mendonca; Fiscal Year: 2006
    ..abstract_text> ..
  49. PET RADIOPHARMACEUTICALS FOR CARDIAC AND OTHER STUDIES
    Michael Welch; Fiscal Year: 2002
    ..The overall goal of this application is to develop and evaluate new PET radiopharmaceuticals that have potential for evaluating diseases of th heart, lung, and vasculature. ..