weight bearing

..Although further work is needed to confirm its validity for more complex geometries the mEFM is envisaged as a good option for application in 3D knee models to predict prosthetic knee performance...

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..To determine whether reducing walking speed is a strategy used by patients with knee osteoarthritis (OA) of varying disease severity to reduce the maximum knee adduction moment...

To compare the outcomes of Weber C ankle fractures treated with syndesmotic screw fixation where the screw was removed prior to weight bearing against those where the screw was left in situ indefinitely.

..of digital video of mice with nerve injuries (chronic constriction or spared nerve injury), and automated assessment of locomotor behavior using photocell detection and dynamic weight bearing (i.e., gait) using the CatWalk system.

..of this systematic review was to find evidence-based support in the literature to allow immediate unrestricted weight bearing after primary uncemented total hip arthroplasty (THA)...

..The importance of preventing generalized osteopenia in the control of AIS progression during the peripubertal period warrants further study...

To evaluate the effects of a food supplemented with fish oil omega-3 fatty acids on weight bearing in dogs with osteoarthritis.

Partial weight bearing is thought to unload and protect the healing bone. Until now, there has been no objective method of assessing the amount of weight placed on the healing zone by the patient...

..of using the resulting cell/scaffold constructs to repair full thickness articular cartilage defects in non-weight bearing area in porcine model within a follow-up of 6 months...

..We made microfinite element models of a healthy and osteoporotic human femur and found that tissue-level strains in the osteoporotic femoral head were 70% higher on average and less uniformly distributed than those in the healthy one...

..The peak force, hysteresis and shape of the force-stretch curve are affected by the stretch rate, rest period, stretch amplitude and the number and magnitude of preconditioning cycles...

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..This study tested the hypothesis that gait changes related to knee osteoarthritis (OA) of varied severity are associated with increased loads at the ankle, knee, and hip...

..The purpose of this study was to compare lower extremity joint kinematics, kinetics, and energetics between individuals having undergone ACL reconstruction and accelerated rehabilitation and healthy individuals...

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..Practical issues related to loading of the joint by weight bearing or other conditions, follow-up intervals, length of follow-up, radiation dose, and the exclusion of patients ..

..Our finding that non-invasive loading increases the bone volume and fraction at a corticocancellous site by as much as 15% motivates exploring the use of mechanical loading to attain greater peak bone mass and inhibit osteoporosis...

..of milnacipran on spinal nerve ligation (SNL)-induced thermal and mechanical hypersensitivity and shift in weight bearing were determined...

..Moreover, endosteal adaptation did not increase with strain rate. Understanding the nature of the stimuli to which bone cells respond to may underpin the development of non-pharmacological treatments devised to enhance bone mass...

To determine if subjects can offload the right lower extremity to a targeted amount of weight bearing using assistive devices.

Knee ligament injuries frequently happen when the joint transitions from non-weight bearing (NWB) to weight bearing (WB)...

..This alteration of the stress distribution has important clinical implications regarding the long-term integrity of the cartilage adjacent to osteochondral defects...

..In the present study, we sought to develop/characterize the pain profile of a rat model of surgically induced osteoarthritis (OA)...

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..Stability and ingrowth may be jeopardized by immediate loading of the implant while functional recovery may be promoted and periprosthetic demineralization reduced...

..The purpose of this study was to compare the effectiveness of a removable cast walker (RCW) rendered irremovable (iTCC) with the total contact cast (TCC) in the treatment of diabetic neuropathic plantar foot ulcers...

..Specifically, the cost of performing work to redirect and accelerate the center of mass is almost twice as great as the cost of generating force to support body weight...

..There was a tendency for over-correction in the CWO group but no significant difference was found. There was no difference in initial stability between CWO and OWO with a rigid locked-plate fixation...

..Both give excellent initial stability and provide significantly improved knee function and reduction in pain, although the opening-wedge technique was more likely to produce the intended correction...

..Adaptation rules appear to be the key to reduce dramatically the number of input parameters for simulating circulation dynamics. The model may be used to simulate circulation pathology and to predict effects of treatment...

..Findings highlight microphysical factors important to cartilage mechanical injury, and suggest ways that macroscopic structural damage may accelerate or, in certain cases, possibly slow the progression of cartilage degeneration...

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..Several studies have reported this association, and several studies have found the association when reporting other aspects of tendinopathy...

..The effectiveness of partial weightbearing after hip surgery has been questioned as well as the need of intensive physiotherapy...

..The purpose of this study was to evaluate the effectiveness of a removable cast walker (RCW) and an "instant" total contact cast (iTCC) in healing neuropathic diabetic foot ulcerations...

..The resistive sensor is required for use where higher pressures are expected despite its inferior accuracy...

We evaluated the possibility of using the video-based Catwalk gait analysis method to measure weight bearing changes and for testing pharmacological antinociception in freely moving mice with lipopolysaccharide (LPS)-induced monoarthritis.

..The results reveal that knee loading is an effective means to enhance bone formation in the tibial diaphysis in a loading-frequency dependent manner without inducing significant in situ strain at the site of bone formation...

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..Flush osteochondral plugs can reduce contact pressure compared with an empty defect in the articular cartilage. However, incongruities such as graft angulation have an unknown effect...

..However, 74% is probably an overestimate of the metabolic demand of body weight to support itself because in reduced gravity conditions decrements in horizontal impulse accompanied decrements in vertical impulse...

..Microgravity has been thought to induce osteoporosis because of reduced weight-bearing. However, up to now, few data have been available about its precise nature and timecourse...

..To study the effect of a single impact on the structure and mechanical properties of cartilage...

..The purpose of this study was to compare the time-zero biomechanical strength and the surface area of repair between a single-row modified Mason-Allen rotator cuff repair and a double-row arthroscopic repair...

..001). In conclusion, our study showed that evaluation of TMA in addition to HAL, FAL, Theta angle, MCT and LCT can be used to determine of the fracture risk independently of BMD...

..We speculate that gymnasts have already adapted their bones (geometry and vBMD) to the demands imposed upon them by the loading they are subjected to during gymnastics and do not benefit from additional calcium supplementation...

..While those studies do not support a major influence of the SNS on the bone mechano-adaptive response, there is nevertheless strong evidence that the SNS is part of a complex system which contributes to the metabolic regulation of bone...

..CONCLUSIONS: This study shows that SN, or the absence of loading function it entails, enhances loading-related new cortical bone formation in the tibia independently of the SNS...

..CLINICAL RELEVANCE: Because the degree of meniscectomy leading to clinically significant outcomes is unknown, a prudent strategy is to preserve the greatest amount of meniscus possible...

..Reduced effectiveness of bone cell responses to bone loading, associated with estrogen-related decline in ERalpha, may contribute to the failure to maintain structurally appropriate bone mass in osteoporosis in both men and women...

..This chapter outlines the techniques involved in these three phases of investigation in mouse bone...

..Hindlimb weight bearing was used as a measure of joint pain, while von Frey hair algesiometry applied to the plantar surface of the ..

..This suggests that the deviatoric component may be the most significant mechanical parameter to guide tissue differentiation during indirect fracture healing...

..002). We conclude that woven bone "repair" of a bone damaged by fatigue loading restores whole-bone strength and enhances resistance to further damage by repetitive loading...

..The effects of mechanical loading on the trabecular bone of the femoral head were not significant. This study suggests that the effect of mechanical loading in the rat-with-backpack model mainly occurs at cortical bone sites...

..The goal of this study was to quantify the biomechanical characteristics of foot-ground contact during a Tai Chi gait (TCG), one of the basic but common Tai Chi Chuan movements...

..LEVEL OF EVIDENCE: Level III, diagnostic study. See the Guidelines for Authors for a complete description of levels of evidence...

..In sum, the data of this study indicate that inserting a 10-s rest interval between each load cycle amplifies bone's response to mechanical loading, even within a peri-threshold range of strain magnitudes and cycle numbers...

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..This paper highlights recent research aimed at joint pressure redistribution, fixation stability and bone healing that has led to improved surgical techniques and a decrease of post-operative time to full weight-bearing...

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..67 MPa. Implanted scaffolds with such properties can then achieve the goal of restoring the disc height and distributing stress under different loading conditions...

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..This study has shown that CEP permeability will only markedly have an effect on fluid movement, and hence convective nutrition, if the permeability of the CEP is reduced to less than that of the disc tissue...

..It was concluded that the trabecular structure of the mandibular condyle is optimal in resisting the compressive and tensile strains to which it is subjected...

..Little is known about the stiffening effect of this fusion-bone mass on the mechanical behavior of the corresponding bone region, including the load distribution between the different parts...

..The flexion/extension curves are asymmetric with a greater magnitude in flexion than in extension. These experimental results will be used to validate FE models of young, normal cervical spines...

..CONCLUSION: SBO does not alter lumbar biomechanics with respect to stress and range of motion. The high coincidence of spondylolysis in spines with SBO may not be due to the mechanical factors...

..Salter innominate osteotomy of the pelvis is widely used to improve the coverage of the femoral head in developmental dysplasia of the hip, but the biomechanical and geometric changes after this osteotomy are not well understood...

..Our data suggest that the particular mobile-bearing prosthesis tested potentially reduces elevated strain levels in the proximal tibia...

..The results suggested that the bilateral EAS model could be used to determine the facet joint contact forces in axial rotation but may result in considerable error in flexion, extension, and lateral bending...

..In the present study, we propose a novel method to determine the nonlinear-elastic behaviors of the skin and the subcutaneous tissue simultaneously using specimens of skin/subcutaneous composites...

..This study also provides insight into how microstructural features effect local distributions and cause a strain magnification effect. Limitations in applying the unit cell methodology approach to bone are also discussed...

..Cadaveric motion segment experiment...

..COL network weakening during in vitro growth due to reduced COL and PYR was accompanied by reduced CC/UCC moduli and increased UCC Poisson's ratios...

..Therefore, a modeling process starting from tomographic data and ending in an applicable finite element model must be elaborated. A possible solution will be presented in this paper...

..These regions mostly contain minimum values in BV/TV, which were found to predict ultimate stress better than average BV/TV...

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..The model shows an excellent capability to describe the tensile behaviour of the cortical bone for the specific mechanical condition analysed...

..The "small" specimens of cortical and cancellous bone were created in the same way as the model of the proximal femur. The results obtained from FE analyses support our above described hypothesis...

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..These data are essential for understanding the aetiology of pressure sores, particularly those that were recently termed "deep tissue injury" at the US National Pressure Ulcer Advisory Panel (NPUAP) 2005 Consensus Conference...

..Comprehensive items of the mechanical properties of the bone can evaluate the mechanical performance of the bone better, and can provide more valuable data to relevant research...

..This paper is a preliminary report on the mechanical properties of the large intestine based on in vivo and in vitro experimental data...

..It is apparent from these observations that complex organization of material properties facilitated distinct strain gradients in dentine structure during mechanical functions...

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..In particular, the tangent modulus of the tissue is seen to increase sharply over a period of 72 h...

..These findings may offer an insight to better understanding the kinematics of the human thoracolumbar spine and provide clinically relevant information for the evaluation of spinal stability and functionality of implant devices...

..5 and 2.5 Nm. Based on these preliminary findings, validation of finite element modeling to ensure biofidelity should consider age as a factor that may affect biomechanics...

..g., vehicle-pedestrian tests)...

..8 +/- 5.7 GPa for the linear region of the loading phase. The data presented in this paper is useful to understand clavicle fractures as well as to develop advanced human computational models...

..The results indicate that the mechanical stability of the lumbar spine is critical component in relation to the tolerable compressive loads...

..We conclude that biochemical crosslinking directly affects measured mechanical properties. Further, this mechanical characterization may prove useful in mapping alterations in stiffness and permeability observed in glycated tissues...

..Some computation results of trabecular bone functional adaptation as well as mechanical design optimization, using the developed system are presented...

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..This could explain why results of earlier studies on the importance of structural parameters can be inconsistent and site-dependent...

..The neck of this implant is a potential zone for fracture when subjected to high bending forces. The reduced-diameter ITI dental implant might benefit from reinforcement of this region...

..This study suggests that fixation or fusion to restore strength and stability of the lumbar spine may be required for surgical intervention of greater than 75% facetectomy...

The arch of the foot is important in performing activities to provide a stable base for weight bearing, flexibility to accommodate different ground conditions, and also to dissipate loads from weight bearing...

..negative molecular mechanisms [G610C/+ (models human type I and IV OI)] to investigate the impact of non-weight bearing (swimming) and weight bearing (treadmill) exercise on muscle strength and bone quality and strength...

..This data is expected to yield new insights into the pathogenesis of OA as well as the mechanical role of collagen types XI and IX in cartilage. ..

..We will then measure males and females on weight bearing knee joint neuromechanics at these specified time points to examine the independent and combined effects of ..

..We will then measure males and females on weight bearing knee joint neuromechanics at these specified time points to examine the independent and combined effects of ..

..We will then measure males and females on weight bearing knee joint neuromechanics at these specified time points to examine the independent and combined effects of ..

..QUS will be assessed with a new dry system device in all those in the original cohort who attend Exam 24 as well as those who receive the standard Framingham home visit. ..

Fracture healing of a weight bearing bone is unique in that loading of the injured bone is required for effective healing of the bone...

Fracture healing of a weight bearing bone is unique in that loading of the injured bone is required for effective healing of the bone...

..Recently, there has been increasing evidence that alterations in lower extremity biomechanical factors during weight bearing activities, such as, alterations in movement and muscle activity patterns, ground reaction forces, and lower ..

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..This is shown by the finding the EA results in about 40% recovery of weight bearing by the hind limb with ankle sprain...

..This is shown by the finding that EA results in about 40% recovery of weight bearing by the hind limb with ankle sprain...

..These subjects will undergo an additional 6 months of weight bearing without vibration following the same schedule to serve as an internal control...

..2.) To determine if there are detectable thickness changes in the weight bearing regions of tibiofemoral cartilage over a 2 year period following ACL reconstruction that are greater than a ..

..distal femur above the knee do not provide an optimum solution for interfacing with a prosthetic socket for weight bearing and ambulation...

..Chronic shoulder pain after SCI has been associated with the repetitive weight bearing of wheelchair propulsion (WCP), but a causal relationship has not been established...

..2) To test the hypothesis that OCT detectable microstructural damage is prevalent in grossly normal appearing weight bearing cartilage of human subjects undergoing arthroscopy to treat degenerative meniscal tears...

..2) To test the hypothesis that OCT detectable microstructural damage is prevalent in grossly normal appearing weight bearing cartilage of human subjects undergoing arthroscopy to treat degenerative meniscal tears...

..Transgenic animals overexpressing G1 domain and LP will be intercrossed to create double transgenic mice, possibly simulating various degrees of aging and/or osteoarthritic processes. ..

..Chronic shoulder pain after SCI has been associated with the repetitive weight bearing of wheelchair propulsion (WCP), but a causal relationship has not been established...

..Chronic shoulder pain after SCI has been associated with the repetitive weight bearing of wheelchair propulsion (WCP), but a causal relationship has not been established...

..Chronic shoulder pain after SCI has been associated with the repetitive weight bearing of wheelchair propulsion (WCP), but a causal relationship has not been established...

..little is known about how the integrative biological response to decreased mechanical loading [hindlimb non-weight bearing (NWB)] leads to fiber-type shifts and altered transcriptional regulation of MyHC genes...

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