weight bearing

Summary

Summary: The physical state of supporting an applied load. This often refers to the weight-bearing bones or joints that support the body's weight, especially those in the spine, hip, knee, and foot.

Top Publications

  1. ncbi Guidelines for standardization of radiostereometry (RSA) of implants
    Edward R Valstar
    Department of Orthopaedics, Leiden University Medical Center, The Netherlands
    Acta Orthop 76:563-72. 2005
  2. doi Mechanical loading enhances the anabolic effects of intermittent parathyroid hormone (1-34) on trabecular and cortical bone in mice
    Toshihiro Sugiyama
    Department of Veterinary Basic Sciences, The Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK
    Bone 43:238-48. 2008
  3. ncbi Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin
    Alexander G Robling
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 283:5866-75. 2008
  4. ncbi Non-invasive axial loading of mouse tibiae increases cortical bone formation and modifies trabecular organization: a new model to study cortical and cancellous compartments in a single loaded element
    Roberto L de Souza
    Department of Veterinary Basic Sciences, Royal Veterinary College, Royal College Street, London NW1 0TU, UK
    Bone 37:810-8. 2005
  5. ncbi Weight bearing as a measure of disease progression and efficacy of anti-inflammatory compounds in a model of monosodium iodoacetate-induced osteoarthritis
    S E Bove
    Department of Inflammation Pharmacology, Pfizer Global Research and Development, Ann Arbor Laboratories, Ann Arbor, MI 48105, USA
    Osteoarthritis Cartilage 11:821-30. 2003
  6. doi Immediate weight bearing after uncemented total hip arthroplasty with an anteverted stem: a prospective randomized comparison using radiostereometry
    Truike M Thien
    Department of Orthopaedics, Sahlgrenska University Hospital, Molndal, Sweden
    Acta Orthop 78:730-8. 2007
  7. ncbi Off-loading the diabetic foot wound: a randomized clinical trial
    D G Armstrong
    Audie L Murphy Veterans Affairs Medical Center, Tucson, AZ 85723, USA
    Diabetes Care 24:1019-22. 2001
  8. ncbi Increased knee joint loads during walking are present in subjects with knee osteoarthritis
    A J Baliunas
    Department of Orthopedic Surgery, Rush Medical College of Rush University, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
    Osteoarthritis Cartilage 10:573-9. 2002
  9. doi Evaluation of the effects of dietary supplementation with fish oil omega-3 fatty acids on weight bearing in dogs with osteoarthritis
    James K Roush
    Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA
    J Am Vet Med Assoc 236:67-73. 2010
  10. ncbi Mapping the structural properties of the lumbosacral vertebral endplates
    J P Grant
    Department of Orthopaedics and Mechanical Engineering, University of British Columbia and Vancouver Hospital and Health Sciences Centre, Vancouver, British Columbia, Canada
    Spine (Phila Pa 1976) 26:889-96. 2001

Research Grants

Detail Information

Publications300 found, 100 shown here

  1. ncbi Guidelines for standardization of radiostereometry (RSA) of implants
    Edward R Valstar
    Department of Orthopaedics, Leiden University Medical Center, The Netherlands
    Acta Orthop 76:563-72. 2005
    ..Practical issues related to loading of the joint by weight bearing or other conditions, follow-up intervals, length of follow-up, radiation dose, and the exclusion of patients ..
  2. doi Mechanical loading enhances the anabolic effects of intermittent parathyroid hormone (1-34) on trabecular and cortical bone in mice
    Toshihiro Sugiyama
    Department of Veterinary Basic Sciences, The Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK
    Bone 43:238-48. 2008
    ..Together, these data suggest that in female C57BL/6 mice, under some but not all circumstances, mechanical loading exerts an osteogenic response with iPTH (1-34) in trabecular and cortical bone...
  3. ncbi Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin
    Alexander G Robling
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 283:5866-75. 2008
    ....
  4. ncbi Non-invasive axial loading of mouse tibiae increases cortical bone formation and modifies trabecular organization: a new model to study cortical and cancellous compartments in a single loaded element
    Roberto L de Souza
    Department of Veterinary Basic Sciences, Royal Veterinary College, Royal College Street, London NW1 0TU, UK
    Bone 37:810-8. 2005
    ....
  5. ncbi Weight bearing as a measure of disease progression and efficacy of anti-inflammatory compounds in a model of monosodium iodoacetate-induced osteoarthritis
    S E Bove
    Department of Inflammation Pharmacology, Pfizer Global Research and Development, Ann Arbor Laboratories, Ann Arbor, MI 48105, USA
    Osteoarthritis Cartilage 11:821-30. 2003
    ....
  6. doi Immediate weight bearing after uncemented total hip arthroplasty with an anteverted stem: a prospective randomized comparison using radiostereometry
    Truike M Thien
    Department of Orthopaedics, Sahlgrenska University Hospital, Molndal, Sweden
    Acta Orthop 78:730-8. 2007
    In uncemented total hip arthroplasty with hydroxyapatite coating, early weight bearing is frequently practiced but there is still not much evidence to support this recommendation.
  7. ncbi Off-loading the diabetic foot wound: a randomized clinical trial
    D G Armstrong
    Audie L Murphy Veterans Affairs Medical Center, Tucson, AZ 85723, USA
    Diabetes Care 24:1019-22. 2001
    ..To compare the effectiveness of total-contact casts (TCCs), removable cast walkers (RCWs), and half-shoes to heal neuropathic foot ulcerations in individuals with diabetes...
  8. ncbi Increased knee joint loads during walking are present in subjects with knee osteoarthritis
    A J Baliunas
    Department of Orthopedic Surgery, Rush Medical College of Rush University, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
    Osteoarthritis Cartilage 10:573-9. 2002
    ..Additionally, this study tests if changes in the knee angles, such as a reduced midstance knee flexion angle, or reduced sagittal plane moments previously identified by others as load reducing mechanisms are present in this OA group...
  9. doi Evaluation of the effects of dietary supplementation with fish oil omega-3 fatty acids on weight bearing in dogs with osteoarthritis
    James K Roush
    Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA
    J Am Vet Med Assoc 236:67-73. 2010
    To evaluate the effects of a food supplemented with fish oil omega-3 fatty acids on weight bearing in dogs with osteoarthritis.
  10. ncbi Mapping the structural properties of the lumbosacral vertebral endplates
    J P Grant
    Department of Orthopaedics and Mechanical Engineering, University of British Columbia and Vancouver Hospital and Health Sciences Centre, Vancouver, British Columbia, Canada
    Spine (Phila Pa 1976) 26:889-96. 2001
    ..The center of the bone, where implants are currently placed, is the weakest part of the lumbar endplates and is not the strongest region of the sacral endplate...
  11. ncbi Potential strategies to reduce medial compartment loading in patients with knee osteoarthritis of varying severity: reduced walking speed
    Anne Mündermann
    Stanford University, Stanford, California 94305 3030, USA
    Arthritis Rheum 50:1172-8. 2004
    ..To determine whether reducing walking speed is a strategy used by patients with knee osteoarthritis (OA) of varying disease severity to reduce the maximum knee adduction moment...
  12. ncbi Reproducibilty of partial weight bearing
    A Malviya
    Fairfield Hospital, Bury, 75 Stockdale Place, Edgbaston, Birmingham B15 3XH, UK
    Injury 36:556-9. 2005
    To find out whether partial weight bearing can be reproduced and retained.
  13. ncbi Partial weight bearing after surgery for fractures of the lower extremity--is it achievable?
    Attila Vasarhelyi
    Abteilung für Unfall und Wiederherstellungschirurgie Klinik und Poliklinik für Chirurgie, Universitat Rostock, Schillingallee 35, 18055 Rostock, Germany
    Gait Posture 23:99-105. 2006
    Partial weight bearing is a generally accepted principle of rehabilitation following trauma or reconstructive surgery of the lower extremity...
  14. ncbi A framework for the in vivo pathomechanics of osteoarthritis at the knee
    Thomas P Andriacchi
    Department of Mechanical Engineering, Stanford University, Division of Biomechanical Engineering, Stanford, CA 94305 4038, USA
    Ann Biomed Eng 32:447-57. 2004
    ..The integrated in vivo framework presented here will be helpful for the interpretation of laboratory experiments as well as for the development of new methods for the evaluation of OA at the knee...
  15. pmc Periprosthetic bone mineral density and fixation of the uncemented CLS stem related to different weight bearing regimes: A randomized study using DXA and RSA in 38 patients followed for 5 years
    Olof Wolf
    Department of Orthopedics, Uppsala University Hospital, Uppsala, Sweden
    Acta Orthop 81:286-91. 2010
    ..Theoretically, bone ingrowth into the implant should benefit from initial partial weight bearing. We investigated whether the degree of postoperative weight bearing influences the periprosthetic bone mineral ..
  16. pmc Hypolocomotion, asymmetrically directed behaviors (licking, lifting, flinching, and shaking) and dynamic weight bearing (gait) changes are not measures of neuropathic pain in mice
    Jeffrey S Mogil
    Department of Psychology and Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC H3A 1B1 Canada
    Mol Pain 6:34. 2010
    ..of digital video of mice with nerve injuries (chronic constriction or spared nerve injury), and automated assessment of locomotor behavior using photocell detection and dynamic weight bearing (i.e., gait) using the CatWalk system.
  17. doi Assessment of weight bearing changes and pharmacological antinociception in mice with LPS-induced monoarthritis using the Catwalk gait analysis system
    Willias Masocha
    Department of Applied Therapeutics, Faculty of Pharmacy, Kuwait University, Kuwait
    Life Sci 85:462-9. 2009
    We evaluated the possibility of using the video-based Catwalk gait analysis method to measure weight bearing changes and for testing pharmacological antinociception in freely moving mice with lipopolysaccharide (LPS)-induced monoarthritis.
  18. ncbi Cartilage viability after repetitive loading: a preliminary report
    E Lucchinetti
    Laboratory for Soft Tissue Research, Hospital for Special Surgery, New York, New York 10021, USA
    Osteoarthritis Cartilage 10:71-81. 2002
    ..To assess matrix changes and chondrocyte viability during static and continuous repetitive mechanical loading in mature bovine articular cartilage explants...
  19. ncbi Low effectiveness of prescribed partial weight bearing. Continuous recording of vertical loads using a new pressure-sensitive insole
    M Tveit
    Department of Orthopaedics, Sahlgrenska University Hospital, Gothenburg, Sweden
    J Rehabil Med 33:42-6. 2001
    To enable objective measurements of weight bearing in hip replacement patients a portable instrument set-up with an on-line registering pressure-sensitive insole was developed...
  20. ncbi Primary stability of four different implants for opening wedge high tibial osteotomy
    J D Agneskirchner
    Department of Trauma and Reconstructive Surgery, Henriettenstiftung Hannover, Germany
    Knee Surg Sports Traumatol Arthrosc 14:291-300. 2006
    ..The results suggest that the implant design strongly influences the primary stability of medial opening wedge tibial osteotomy. A rigid long plate fixator with angle-stable locking bolts yields the best results...
  21. ncbi Substrate deformation levels associated with routine physical activity are less stimulatory to bone cells relative to loading-induced oscillatory fluid flow
    J You
    Department of Orthopaedics and Rehabilitation, Pennsylvania State University College of Medicine, Hershey 17033, USA
    J Biomech Eng 122:387-93. 2000
    ..These data suggest that, relative to fluid flow, substrate deformation may play less of a role in bone cell mechanotransduction associated with bone adaptation to routine loads...
  22. ncbi Measurement of the deformation of isolated chondrocytes in agarose subjected to cyclic compression
    M M Knight
    IRC in Biomedical Materials, Queen Mary and Westfield College, London, UK
    Med Eng Phys 20:684-8. 1998
    ..72), although during static compression the cell deformation remained constant. This system may be used to examine cellular events under a range of dynamic mechanical stimuli...
  23. ncbi A finite element model of the human knee joint for the study of tibio-femoral contact
    Tammy L Haut Donahue
    Department of Mechanical Engineering, Michigan Technological University, Houghton 49931, USA
    J Biomech Eng 124:273-80. 2002
    ..However, unrealistic constraints on rotations other than flexion/extension can result in relatively large errors in contact variables...
  24. doi Biofeedback training for partial weight bearing in patients after total hip arthroplasty
    Zoltan Pataky
    Service of Therapeutic Education for Chronic Diseases, World Health Organization Collaborating Centre, Department of Community Medicine, University Hospitals of Geneva, Geneva, Switzerland
    Arch Phys Med Rehabil 90:1435-8. 2009
    ..To evaluate a new biofeedback training method based on visual delivery of information in patients after total hip arthroplasty (THA)...
  25. pmc Early full weight bearing is safe in open-wedge high tibial osteotomy
    Justus Martijn Brinkman
    Limb Deformity Reconstruction Unit, Department of Orthopaedics, The Netherlands
    Acta Orthop 81:193-8. 2010
    ..Angle-stable implants offer superior initial stability. Early full weight bearing appears to be possible using these implants...
  26. ncbi Loss in mechanical contact of cementless acetabular prostheses due to post-operative weight bearing: a biomechanical model
    Chiara Maria Bellini
    Laboratory of Biological Structure Mechanics, Politecnico di Milano, Milan, Italy
    Med Eng Phys 29:175-81. 2007
    ..the first step was calculated and assumed as an index of variation in mechanical contact due to post-operative weight bearing. The results show that, due to hip loading, contact pressures given by press-fit increase in the postero-..
  27. ncbi Pedobarographic findings in patients with knee osteoarthritis
    Evren Kul-Panza
    Physical Medicine and Rehabilitation Department, Marmara University School of Medicine, Istanbul, Turkey
    Am J Phys Med Rehabil 85:228-33. 2006
    ..The aim of this study was to evaluate pedobarographic findings and balance in knee osteoarthritis...
  28. ncbi Rest-inserted loading rapidly amplifies the response of bone to small increases in strain and load cycles
    Sundar Srinivasan
    Dept of Orthopaedics, University of Washington, Seattle, WA 98104 2499, USA
    J Appl Physiol (1985) 102:1945-52. 2007
    ..In sum, the data of this study indicate that inserting a 10-s rest interval between each load cycle amplifies bone's response to mechanical loading, even within a peri-threshold range of strain magnitudes and cycle numbers...
  29. ncbi The difference between actual and prescribed weight bearing of total hip patients with a trochanteric osteotomy: long-term vertical force measurements inside and outside the hospital
    Henri L Hurkmans
    Department of Physical Therapy, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Arch Phys Med Rehabil 88:200-6. 2007
    ..To determine whether patients load the operated leg at a prescribed weight-bearing target load during postoperative recovery...
  30. ncbi Knee joint loading differs in individuals with mild compared with moderate medial knee osteoarthritis
    Laura E Thorp
    Rush University Medical Center, Chicago, Illinois 60612, USA
    Arthritis Rheum 54:3842-9. 2006
    ....
  31. ncbi Tibio-femoral movement in the living knee. A study of weight bearing and non-weight bearing knee kinematics using 'interventional' MRI
    P Johal
    Department of Orthopaedics, St Mary s Hospital, W2 1NY London, UK
    J Biomech 38:269-76. 2005
    ..flexion under loaded and unloaded conditions, but the magnitude of rotation is greater and occurs earlier on weight bearing. With flexion plus tibial internal rotation, the pattern of movement follows that in neutral...
  32. ncbi Generalized low bone mass of girls with adolescent idiopathic scoliosis is related to inadequate calcium intake and weight bearing physical activity in peripubertal period
    Warren T K Lee
    Department of Orthopaedics and Traumatology, 5 F, Clinical Sciences Building, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Osteoporos Int 16:1024-35. 2005
    ..The importance of preventing generalized osteopenia in the control of AIS progression during the peripubertal period warrants further study...
  33. ncbi Does partial weight bearing unload a healing bone in external ring fixation?
    Georg N Duda
    Research Laboratory, Department of Trauma and Reconstructive Surgery, Charite, Campus Virchow Klinikum, Humboldt University of Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Langenbecks Arch Surg 388:298-304. 2003
    Partial weight bearing is thought to unload and protect the healing bone. Until now, there has been no objective method of assessing the amount of weight placed on the healing zone by the patient...
  34. ncbi Hip abduction moment and protection against medial tibiofemoral osteoarthritis progression
    Alison Chang
    Division of Rheumatology, Feinberg School of Medicine, Northwestern University, 240 East Huron, Chicago, IL 60611, USA
    Arthritis Rheum 52:3515-9. 2005
    ..To test the hypothesis that a greater peak internal hip abduction moment is associated with a reduced likelihood of ipsilateral medial tibiofemoral osteoarthritis (OA) progression...
  35. ncbi Contact stresses and fatigue life in a knee prosthesis: comparison between in vitro measurements and computational simulations
    Tomaso Villa
    Dipartimento di Ingegneria Strutturale and Dipartimento di Bioingegneria, Laboratory of Biological Structure Mechanics, Politecnico di Milano, Piazza Leonardo da Vinci 32, Milano 20133, Italy
    J Biomech 37:45-53. 2004
    ..The failure risk was estimated with a standard fatigue criterion on the basis of the results obtained from the FEM calculations. Experimental and computational results showed a positive matching...
  36. ncbi Consensus statements and recommended clinical procedures regarding loading protocols for endosseous dental implants
    David L Cochran
    Department of Periodontics, The University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, Texas 78229 3900, USA
    Int J Oral Maxillofac Implants 19:109-13. 2004
  37. ncbi The monosodium iodoacetate model of osteoarthritis: a model of chronic nociceptive pain in rats?
    Rachel Combe
    Pain Therapeutics, Pfizer Global Research and Development, Ramsgate Road, Sandwich, Kent CT139NJ, UK
    Neurosci Lett 370:236-40. 2004
    ..Changes in hind paw weight distribution were also determined. Both punctate allodynia and a weight bearing deficit were observed in MIA-treated rats for up to 10 weeks...
  38. ncbi Characterization of cartilage metabolic response to static and dynamic stress using a mechanical explant test system
    P A Torzilli
    Laboratory for Soft Tissue Research, Hospital for Special Surgery, NY 10021, USA
    J Biomech 30:1-9. 1997
    ..Furthermore, the observed decreased metabolism may be more representative of the in situ tissue response than that of unloaded explants, in which we found an increasing rate of metabolism for up to 6 days after explant removal...
  39. ncbi Effect of load on articular cartilage matrix and the development of guinea-pig osteoarthritis
    L Wei
    Department of Orthopaedic Surgery, Huddinge University Hospital, Karolinska Institutet, Stockholm, S-141 86, Sweden
    Osteoarthritis Cartilage 9:447-53. 2001
    ..These changes eventually result in a cartilage devoid in aggrecan, as also has been demonstrated in advanced human OA. All of this makes primary guinea-pig OA a suitable model for studying early OA changes...
  40. ncbi NACOB presentation to ASB Young Scientist Award: Postdoctoral. The impact of boundary conditions and mesh size on the accuracy of cancellous bone tissue modulus determination using large-scale finite-element modeling. North American Congress on Biomechani
    C R Jacobs
    Department of Orthopaedics and Rehabilitation, Pennsylvania State University, Hershey 17033, USA
    J Biomech 32:1159-64. 1999
    ..In conclusion, we found that this approach is an effective method for determining the average trabecular hard tissue properties of human cancellous bone with an expected practical accuracy level better than 5%...
  41. ncbi Dynamic cervical plates: biomechanical evaluation of load sharing and stiffness
    D S Brodke
    Orthopedic Bioengineering Research Laboratory, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    Spine (Phila Pa 1976) 26:1324-9. 2001
    ..An in vitro biomechanical study using a simulated cervical corpectomy model to compare the load-sharing properties and stiffnesses of two static and two dynamic cervical plates...
  42. ncbi One-dimensional viscoelastic behavior of fibroblast populated collagen matrices
    Jessica E Wagenseil
    Department of Cell Biology and Physiology, Washington University School of Medicine, 660 S Euclid, CB 8228, St Louis, MO 63110, USA
    J Biomech Eng 125:719-25. 2003
    ..The peak force, hysteresis and shape of the force-stretch curve are affected by the stretch rate, rest period, stretch amplitude and the number and magnitude of preconditioning cycles...
  43. doi Knee kinematics, cartilage morphology, and osteoarthritis after ACL injury
    Ajit M W Chaudhari
    Department of Orthopaedics, OSU Sports Medicine Center, Ohio State University, 2050 Kenny Road, Columbus, OH 43221, USA
    Med Sci Sports Exerc 40:215-22. 2008
    ....
  44. ncbi Loading history determines the velocity of actin-network growth
    Sapun H Parekh
    UCSF UC Berkeley Joint Graduate Group in Bioengineering, University of California at Berkeley, CA 94720, USA
    Nat Cell Biol 7:1219-23. 2005
    ....
  45. ncbi Secondary gait changes in patients with medial compartment knee osteoarthritis: increased load at the ankle, knee, and hip during walking
    Annegret Mundermann
    Stanford University Medical Center, Stanford, California 94305 4038, USA
    Arthritis Rheum 52:2835-44. 2005
    ..This study tested the hypothesis that gait changes related to knee osteoarthritis (OA) of varied severity are associated with increased loads at the ankle, knee, and hip...
  46. ncbi Gait biomechanics are not normal after anterior cruciate ligament reconstruction and accelerated rehabilitation
    P Devita
    Department of Exercise and Sport Science, East Carolina University, Greenville, NC 27858, USA
    Med Sci Sports Exerc 30:1481-8. 1998
    ..The purpose of this study was to compare lower extremity joint kinematics, kinetics, and energetics between individuals having undergone ACL reconstruction and accelerated rehabilitation and healthy individuals...
  47. ncbi Trabecular bone tissue strains in the healthy and osteoporotic human femur
    B van Rietbergen
    Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
    J Bone Miner Res 18:1781-8. 2003
    ..We made microfinite element models of a healthy and osteoporotic human femur and found that tissue-level strains in the osteoporotic femoral head were 70% higher on average and less uniformly distributed than those in the healthy one...
  48. ncbi Viability and volume of in situ bovine articular chondrocytes-changes following a single impact and effects of medium osmolarity
    Peter G Bush
    School of Biomedical and Clinical Laboratory Sciences, University Medical School, Hugh Robson Building, George Square, University of Edinburgh, Edinburgh EH8 9XD, Scotland, UK
    Osteoarthritis Cartilage 13:54-65. 2005
    ....
  49. doi Repair of articular cartilage defect in non-weight bearing areas using adipose derived stem cells loaded polyglycolic acid mesh
    Lei Cui
    Department of Plastic and Reconstructive Surgery, Shanghai 9th People s Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhi Zao Ju Road, Shanghai 200011, PR China
    Biomaterials 30:2683-93. 2009
    ..of using the resulting cell/scaffold constructs to repair full thickness articular cartilage defects in non-weight bearing area in porcine model within a follow-up of 6 months...
  50. doi Partial versus unrestricted weight bearing after an uncemented femoral stem in total hip arthroplasty: recommendation of a concise rehabilitation protocol from a systematic review of the literature
    A M Hol
    Department of Physiotherapy, Rijnstate Hospital, Arnhem, The Netherlands
    Arch Orthop Trauma Surg 130:547-55. 2010
    ..of this systematic review was to find evidence-based support in the literature to allow immediate unrestricted weight bearing after primary uncemented total hip arthroplasty (THA)...
  51. ncbi Syndesmotic screw fixation in Weber C ankle injuries--should the screw be removed before weight bearing?
    David Paul Bell
    Department of Orthopaedic Surgery, Changi General Hospital, 2 Simei Street 3, Singapore 529889, Republic of Singapore
    Injury 37:891-8. 2006
    To compare the outcomes of Weber C ankle fractures treated with syndesmotic screw fixation where the screw was removed prior to weight bearing against those where the screw was left in situ indefinitely.
  52. ncbi Risk factors for lumbar disc degeneration: a 5-year prospective MRI study in asymptomatic individuals
    Achim Elfering
    Department of Psychology, University of Berne, Switzerland
    Spine (Phila Pa 1976) 27:125-34. 2002
    ..A longitudinal magnetic resonance imaging investigation of lumbar disc degeneration in asymptomatic individuals was conducted...
  53. ncbi Osteochondral defects in the human knee: influence of defect size on cartilage rim stress and load redistribution to surrounding cartilage
    Joseph H Guettler
    Department of Orthopaedic Surgery, William Beaumont Hospital, Royal Oak, Michigan, USA
    Am J Sports Med 32:1451-8. 2004
    ....
  54. ncbi Comparison of biophysical stimuli for mechano-regulation of tissue differentiation during fracture healing
    Hanna Isaksson
    Department of Biomedical Engineering, Eindhoven University of Technology, The Netherlands
    J Biomech 39:1507-16. 2006
    ..This suggests that the deviatoric component may be the most significant mechanical parameter to guide tissue differentiation during indirect fracture healing...
  55. ncbi Loading induces site-specific increases in mineral content assessed by microcomputed tomography of the mouse tibia
    J C Fritton
    Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA
    Bone 36:1030-8. 2005
    ..Our finding that non-invasive loading increases the bone volume and fraction at a corticocancellous site by as much as 15% motivates exploring the use of mechanical loading to attain greater peak bone mass and inhibit osteoporosis...
  56. ncbi The effect of angled osteochondral grafting on contact pressure: a biomechanical study
    Jason Lee Koh
    Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Am J Sports Med 34:116-9. 2006
    ..Flush osteochondral plugs can reduce contact pressure compared with an empty defect in the articular cartilage. However, incongruities such as graft angulation have an unknown effect...
  57. pmc Sex differences in coupled knee motions during the transition from non-weight bearing to weight bearing
    Sandra J Shultz
    Department of Exercise and Sport Science, University of North Carolina at Greensboro, 1408 Walker Avenue, Greensboro, North Carolina 27402, USA
    J Orthop Res 27:717-23. 2009
    Knee ligament injuries frequently happen when the joint transitions from non-weight bearing (NWB) to weight bearing (WB)...
  58. ncbi Evaluation of removable and irremovable cast walkers in the healing of diabetic foot wounds: a randomized controlled trial
    David G Armstrong
    Center for Lower Extremity Ambulatory Research, Dr William M Scholl College of Podiatric Medicine at Rosalind Franklin University of Medicine and Science, 3333 Green Bay Rd, North Chicago, IL 60064, USA
    Diabetes Care 28:551-4. 2005
    ..The purpose of this study was to evaluate the effectiveness of a removable cast walker (RCW) and an "instant" total contact cast (iTCC) in healing neuropathic diabetic foot ulcerations...
  59. ncbi Effects of abnormal posture on capsular ligament elongations in a computational model subjected to whiplash loading
    Brian D Stemper
    Department of Neurosurgery, Medical College of Wisconsin, 9200 West Wisconsin Avenue, VA Medical Center, Milwaukee, WI 53226, USA
    J Biomech 38:1313-23. 2005
    ....
  60. ncbi Unrestricted weight bearing and intensive physiotherapy after uncemented total hip arthroplasty
    H Strom
    Department of Orthopaedics, University of Uppsala, Sweden
    Scand J Surg 95:55-60. 2006
    ..The effectiveness of partial weightbearing after hip surgery has been questioned as well as the need of intensive physiotherapy...
  61. ncbi Adaptation to mechanical load determines shape and properties of heart and circulation: the CircAdapt model
    Theo Arts
    Dept of Biophysics, Faculty of Medicine, University of Maastricht, PO Box 616, 6200 MD Maastricht, The Netherlands
    Am J Physiol Heart Circ Physiol 288:H1943-54. 2005
    ..Adaptation rules appear to be the key to reduce dramatically the number of input parameters for simulating circulation dynamics. The model may be used to simulate circulation pathology and to predict effects of treatment...
  62. ncbi Tibiofemoral contact mechanics after serial medial meniscectomies in the human cadaveric knee
    Stephen J Lee
    The Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Am J Sports Med 34:1334-44. 2006
    ..There is no consensus regarding the extent of meniscectomy leading to deleterious effects on tibiofemoral contact mechanics...
  63. ncbi Partial weight-bearing gait using conventional assistive devices
    James W Youdas
    Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA
    Arch Phys Med Rehabil 86:394-8. 2005
    To determine if subjects can offload the right lower extremity to a targeted amount of weight bearing using assistive devices.
  64. ncbi Independent metabolic costs of supporting body weight and accelerating body mass during walking
    Alena Grabowski
    Dept of Integrative Physiology, Univ of Colorado, 354 UCB, Boulder, CO 80309 0354, USA
    J Appl Physiol (1985) 98:579-83. 2005
    ..Specifically, the cost of performing work to redirect and accelerate the center of mass is almost twice as great as the cost of generating force to support body weight...
  65. ncbi A randomized trial of two irremovable off-loading devices in the management of plantar neuropathic diabetic foot ulcers
    Ira A Katz
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Miami, DRI Building, 1450 N W 10th Ave, Room 3054, P O Box 016960 D110, Miami, FL 33101, USA
    Diabetes Care 28:555-9. 2005
    ..The purpose of this study was to compare the effectiveness of a removable cast walker (RCW) rendered irremovable (iTCC) with the total contact cast (TCC) in the treatment of diabetic neuropathic plantar foot ulcers...
  66. ncbi Strain rate influences periosteal adaptation in mature bone
    Jeremy M Lamothe
    Faculty of Kinesiology, McCaig Centre for Joint Injury and Arthritis Research, University of Calgary, Alta, Canada
    Med Eng Phys 27:277-84. 2005
    ..Moreover, endosteal adaptation did not increase with strain rate. Understanding the nature of the stimuli to which bone cells respond to may underpin the development of non-pharmacological treatments devised to enhance bone mass...
  67. pmc Osteocyte apoptosis controls activation of intracortical resorption in response to bone fatigue
    Luis Cardoso
    Department of Biomedical Engineering, The City College of New York, New York, New York 10031, USA
    J Bone Miner Res 24:597-605. 2009
    ....
  68. ncbi Vasoactive intestinal peptide (VIP) is a modulator of joint pain in a rat model of osteoarthritis
    Jason J McDougall
    Department of Physiology and Biophysics, University of Calgary, 3330, Hospital Drive NW, Calgary, Alta, Canada T2N 4N1
    Pain 123:98-105. 2006
    ..Hindlimb weight bearing was used as a measure of joint pain, while von Frey hair algesiometry applied to the plantar surface of the ..
  69. ncbi Diaphyseal bone formation in murine tibiae in response to knee loading
    Ping Zhang
    Department of Anatomy and Cell Biology, Indiana University Purdue University Indianapolis, Indiana 46202, USA
    J Appl Physiol 100:1452-9. 2006
    ..The results reveal that knee loading is an effective means to enhance bone formation in the tibial diaphysis in a loading-frequency dependent manner without inducing significant in situ strain at the site of bone formation...
  70. ncbi Ground contact characteristics of Tai Chi gait
    Ge Wu
    Department of Physical Therapy, University of Vermont, 305 Rowell Building, Burlington, VT 05401, USA
    Gait Posture 22:32-9. 2005
    ..The goal of this study was to quantify the biomechanical characteristics of foot-ground contact during a Tai Chi gait (TCG), one of the basic but common Tai Chi Chuan movements...
  71. ncbi No negative effects of bone impaction grafting with bone and ceramic mixtures
    J J Chris Arts
    From the Orthopaedic Research Laboratory, Department of Orthopedics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Orthop Relat Res 438:239-47. 2005
    ....
  72. ncbi Accuracy and initial stability of open- and closed-wedge high tibial osteotomy: a cadaveric RSA study
    Robert D A Gaasbeek
    Department of Orthopaedic Surgery, University Medical Center Nijmegen St Radboud, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Knee Surg Sports Traumatol Arthrosc 13:689-94. 2005
    ..There was a tendency for over-correction in the CWO group but no significant difference was found. There was no difference in initial stability between CWO and OWO with a rigid locked-plate fixation...
  73. ncbi Opening wedge high tibial osteotomy: an operative technique and rehabilitation program to decrease complications and promote early union and function
    Frank R Noyes
    Cincinnati Sportsmedicine Research and Education Foundation, 10663 Montgomery Road, Cincinnati, OH 45242, USA
    Am J Sports Med 34:1262-73. 2006
    ..High tibial osteotomy has been associated with significant complications, including delayed union or nonunion, loss of correction, arthrofibrosis, and patella infera...
  74. ncbi Sympathetic nervous system does not mediate the load-induced cortical new bone formation
    Roberto L de Souza
    Department of Veterinary Basic Sciences, Royal Veterinary College, London, United Kingdom
    J Bone Miner Res 20:2159-68. 2005
    ....
  75. ncbi Effects of damage in the articular surface on the cartilage response to injurious compression in vitro
    V Morel
    Cartilage Biomechanics Group, Ecole Polytechnique Federale de Lausanne EPFL, AA B019, CH 1015 Lausanne, Switzerland
    J Biomech 39:924-30. 2006
    ..Findings highlight microphysical factors important to cartilage mechanical injury, and suggest ways that macroscopic structural damage may accelerate or, in certain cases, possibly slow the progression of cartilage degeneration...
  76. doi Single-row modified mason-allen versus double-row arthroscopic rotator cuff repair: a biomechanical and surface area comparison
    Cory O Nelson
    Department of Orthopaedic Surgery, SUNY at Stony Brook University Hospital, Stony Brook, New York, USA
    Arthroscopy 24:941-8. 2008
    ..The purpose of this study was to compare the time-zero biomechanical strength and the surface area of repair between a single-row modified Mason-Allen rotator cuff repair and a double-row arthroscopic repair...
  77. ncbi Calcium supplementation and weight bearing physical activity--do they have a combined effect on the bone density of pre-pubertal children?
    K A Ward
    Imaging Science and Biomedical Engineering, University of Manchester, Manchester, M13 9PT, UK
    Bone 41:496-504. 2007
    ..We speculate that gymnasts have already adapted their bones (geometry and vBMD) to the demands imposed upon them by the loading they are subjected to during gymnastics and do not benefit from additional calcium supplementation...
  78. ncbi Sympathetic nervous system and bone adaptive response to its mechanical environment
    M Marenzana
    Royal Veterinary College, London, UK
    J Musculoskelet Neuronal Interact 8:111-20. 2008
    ..While those studies do not support a major influence of the SNS on the bone mechano-adaptive response, there is nevertheless strong evidence that the SNS is part of a complex system which contributes to the metabolic regulation of bone...
  79. ncbi Bone formation after damaging in vivo fatigue loading results in recovery of whole-bone monotonic strength and increased fatigue life
    Matthew J Silva
    Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Washington University, St Louis, Missouri 63110, USA
    J Orthop Res 25:252-61. 2007
    ..002). We conclude that woven bone "repair" of a bone damaged by fatigue loading restores whole-bone strength and enhances resistance to further damage by repetitive loading...
  80. doi Adiposity and tendinopathy
    J E Gaida
    Deakin University, Melbourne, Victoria, Australia
    Disabil Rehabil 30:1555-62. 2008
    ..Several studies have reported this association, and several studies have found the association when reporting other aspects of tendinopathy...
  81. ncbi Additional weight bearing during exercise and estrogen in the rat: the effect on bone mass, turnover, and structure
    A M Tromp
    Department of Endocrinology, Vrije Universiteit Medical Center, De Boelelaan 1117, 1007 MB, Amsterdam, The Netherlands
    Calcif Tissue Int 79:404-15. 2006
    ..The effects of mechanical loading on the trabecular bone of the femoral head were not significant. This study suggests that the effect of mechanical loading in the rat-with-backpack model mainly occurs at cortical bone sites...
  82. pmc Weightbearing anteroposterior pelvic radiographs are recommended in DDH assessment
    Anders Troelsen
    Orthopaedic Research Unit, University Hospital of Aarhus, Tage Hansens Gade 2, Building 7B, DK 8000, Aarhus C, Denmark
    Clin Orthop Relat Res 466:813-9. 2008
    ..We recommend weightbearing anteroposterior pelvic radiographs be obtained to assess DDH given the differences in pelvic flexion-extension and interpretations of acetabular version...
  83. ncbi Wnt/beta-catenin signaling is a component of osteoblastic bone cell early responses to load-bearing and requires estrogen receptor alpha
    Victoria J Armstrong
    Department of Veterinary Basic Sciences, The Royal Veterinary College, Royal College Street, London, United Kingdom
    J Biol Chem 282:20715-27. 2007
    ..Reduced effectiveness of bone cell responses to bone loading, associated with estrogen-related decline in ERalpha, may contribute to the failure to maintain structurally appropriate bone mass in osteoporosis in both men and women...
  84. ncbi Nonwindowed nonremovable fiberglass off-loading cast versus removable pneumatic cast (AircastXP Diabetic Walker) in the treatment of neuropathic noninfected plantar ulcers: a randomized prospective trial
    Carlo Caravaggi
    Ospedale di Abbiategrasso, Department of Diabetic Foot Pathology, Pz Mussi 1, Abbiategrasso Milano 20080, Italy
    Diabetes Care 30:2577-8. 2007
  85. ncbi Effects of independently altering body weight and body mass on the metabolic cost of running
    Lennart P J Teunissen
    Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA
    J Exp Biol 210:4418-27. 2007
    ..However, 74% is probably an overestimate of the metabolic demand of body weight to support itself because in reduced gravity conditions decrements in horizontal impulse accompanied decrements in vertical impulse...
  86. ncbi Effect of a single impact loading on the structure and mechanical properties of articular cartilage
    A Verteramo
    Division of Bioengineering, Academic Unit of Musculoskeletal Disease, Faculty of Medicine and Health, University of Leeds, Leeds, UK
    J Biomech 40:3580-9. 2007
    ..To study the effect of a single impact on the structure and mechanical properties of cartilage...
  87. doi Osteotomies around the knee: patient selection, stability of fixation and bone healing in high tibial osteotomies
    J M Brinkman
    Department of Orthopaedics, Limb Deformity Reconstruction Unit, Sint Maartenskliniek, Hengstdal 3, 6522 JV, Nijmegen, The Netherlands
    J Bone Joint Surg Br 90:1548-57. 2008
    ..This paper highlights recent research aimed at joint pressure redistribution, fixation stability and bone healing that has led to improved surgical techniques and a decrease of post-operative time to full weight-bearing...
  88. ncbi Effects of long-term microgravity exposure on cancellous and cortical weight-bearing bones of cosmonauts
    L Vico
    Laboratoire de Biologie et Biochimie du Tissu Osseaux, INSERM E9901, GIP Exercice, Faculté de Médecine de St Etienne, France
    Lancet 355:1607-11. 2000
    ..Microgravity has been thought to induce osteoporosis because of reduced weight-bearing. However, up to now, few data have been available about its precise nature and timecourse...
  89. ncbi A new value of proximal femur geometry to evaluate hip fracture risk: true moment arm
    H Ulusoy
    Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Gaziosmanpasa University, Tokat, Turkey
    Hip Int 18:101-7. 2008
    ..001). In conclusion, our study showed that evaluation of TMA in addition to HAL, FAL, Theta angle, MCT and LCT can be used to determine of the fracture risk independently of BMD...
  90. ncbi No adverse effects of early weight bearing after uncemented total hip arthroplasty: a randomized study of 20 patients
    Henrik Bodén
    Division of Orthopaedics, Karolinska Institutet at Danderyd Hospital, SE 182 88 Stockholm, Sweden
    Acta Orthop Scand 75:21-9. 2004
    ..Stability and ingrowth may be jeopardized by immediate loading of the implant while functional recovery may be promoted and periprosthetic demineralization reduced...
  91. ncbi Surgically induced osteoarthritis in the rat results in the development of both osteoarthritis-like joint pain and secondary hyperalgesia
    S E Bove
    Department of Inflammation Biology, Pfizer Global Research and Development, Michigan Laboratories, Ann Arbor, MI 48105, USA
    Osteoarthritis Cartilage 14:1041-8. 2006
    ..In the present study, we sought to develop/characterize the pain profile of a rat model of surgically induced osteoarthritis (OA)...
  92. doi Fixation stability of opening- versus closing-wedge high tibial osteotomy: a randomised clinical trial using radiostereometry
    J W H Luites
    Department of Research, Development and Education, Radboud University Nijmegen Medical Centre, P O Box 910, 6500HB Nijmegen, The Netherlands
    J Bone Joint Surg Br 91:1459-65. 2009
    ..Both give excellent initial stability and provide significantly improved knee function and reduction in pain, although the opening-wedge technique was more likely to produce the intended correction...
  93. ncbi Effect of the size and location of osteochondral defects in degenerative arthritis. A finite element simulation
    Estefania Peña
    Group of Structural Mechanics and Materials Modelling, Aragon Institute of Engineering Research I3A, University of Zaragoza, Maria de Luna, 3 E 50018 Zaragoza, Spain
    Comput Biol Med 37:376-87. 2007
    ..This alteration of the stress distribution has important clinical implications regarding the long-term integrity of the cartilage adjacent to osteochondral defects...
  94. ncbi Comparison of capacitive versus resistive joint contact stress sensors
    L Martinelli
    Motion Analysis Laboratory, University Hospital Muenster, Muenster, Germany
    Clin Orthop Relat Res 447:214-20. 2006
    ..The resistive sensor is required for use where higher pressures are expected despite its inferior accuracy...
  95. doi Assessment of the in vivo adaptive response to mechanical loading
    Leanne Kaye Saxon
    Royal Veterinary College, London, UK
    Methods Mol Biol 455:307-22. 2008
    ..This chapter outlines the techniques involved in these three phases of investigation in mouse bone...
  96. ncbi Differential blockade of nerve injury-induced shift in weight bearing and thermal and tactile hypersensitivity by milnacipran
    Tamara King
    Department of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona 85724, USA
    J Pain 7:513-20. 2006
    ..of milnacipran on spinal nerve ligation (SNL)-induced thermal and mechanical hypersensitivity and shift in weight bearing were determined...
  97. ncbi Biomechanical comparison of lumbar spine with or without spina bifida occulta. A finite element analysis
    K Sairyo
    Department of Bioengineering, Spine Research Center, University of Toledo, Toledo, OH 43606, USA
    Spinal Cord 44:440-4. 2006
    ..Biomechanical study using finite element model (FEM) of lumbar spine...
  98. ncbi Effects of fusion-bone stiffness on the mechanical behavior of the lumbar spine after vertebral body replacement
    Antonius Rohlmann
    Biomechanics Laboratory, Charite Campus Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, Germany
    Clin Biomech (Bristol, Avon) 21:221-7. 2006
    ..Little is known about the stiffening effect of this fusion-bone mass on the mechanical behavior of the corresponding bone region, including the load distribution between the different parts...
  99. ncbi The biomechanical response of spinal cord tissue to uniaxial loading
    R J Oakland
    School of Mechanical Engineering, University of Leeds, Leeds, UK
    Proc Inst Mech Eng H 220:489-92. 2006
    ..In particular, the tangent modulus of the tissue is seen to increase sharply over a period of 72 h...
  100. ncbi Strength of the cervical spine in compression and bending
    Andrzej S Przybyla
    Department of Anatomy, University of Bristol, Bristol, United Kingdom
    Spine (Phila Pa 1976) 32:1612-20. 2007
    ..Cadaveric motion segment experiment...
  101. pmc Articular cartilage mechanical and biochemical property relations before and after in vitro growth
    Timothy Ficklin
    Department of Mechanical Engineering, California Polytechnic State University, San Luis Obispo, CA 93407, USA
    J Biomech 40:3607-14. 2007
    ..COL network weakening during in vitro growth due to reduced COL and PYR was accompanied by reduced CC/UCC moduli and increased UCC Poisson's ratios...

Research Grants86

  1. KINEMATICS AND STABILITY OF THE ARCH OF THE FOOT
    Harold Kitaoka; Fiscal Year: 2001
    The arch of the foot is important in performing activities to provide a stable base for weight bearing, flexibility to accommodate different ground conditions, and also to dissipate loads from weight bearing...
  2. Mechanotransduction Approach to Improve Bone Quality in Osteogenesis Imperfecta
    Charlotte L Phillips; Fiscal Year: 2010
    ..negative molecular mechanisms [G610C/+ (models human type I and IV OI)] to investigate the impact of non-weight bearing (swimming) and weight bearing (treadmill) exercise on muscle strength and bone quality and strength...
  3. CARTILAGE MECHANICS IN SMALL ANIMAL MODELS OF OA
    Lori Setton; Fiscal Year: 2001
    ..This data is expected to yield new insights into the pathogenesis of OA as well as the mechanical role of collagen types XI and IX in cartilage. ..
  4. Hormone Mediated Knee Joint Laxity and Neuromechanics
    SANDRA SHULTZ; Fiscal Year: 2007
    ..We will then measure males and females on weight bearing knee joint neuromechanics at these specified time points to examine the independent and combined effects of ..
  5. Hormone Mediated Knee Joint Laxity and Neuromechanics
    SANDRA SHULTZ; Fiscal Year: 2007
    ..We will then measure males and females on weight bearing knee joint neuromechanics at these specified time points to examine the independent and combined effects of ..
  6. Hormone Mediated Knee Joint Laxity and Neuromechanics
    SANDRA SHULTZ; Fiscal Year: 2009
    ..We will then measure males and females on weight bearing knee joint neuromechanics at these specified time points to examine the independent and combined effects of ..
  7. RISK FACTORS FOR AGED RELATED BONE LOSS
    Douglas Kiel; Fiscal Year: 2000
    ..QUS will be assessed with a new dry system device in all those in the original cohort who attend Exam 24 as well as those who receive the standard Framingham home visit. ..
  8. PERIPHERAL NOCICEPTORS IN PERSISTENT PAIN
    PATRICK WILLIAM MANTYH; Fiscal Year: 2010
    Fracture healing of a weight bearing bone is unique in that loading of the injured bone is required for effective healing of the bone...
  9. PERIPHERAL NOCICEPTORS IN PERSISTENT PAIN
    Patrick Mantyh; Fiscal Year: 2009
    Fracture healing of a weight bearing bone is unique in that loading of the injured bone is required for effective healing of the bone...
  10. KNEE STABILITY TRAINING IN INDIVDUALS WITH KNEE OSTEOARTHRITIS
    G Fitzgerald; Fiscal Year: 2007
    ..Recently, there has been increasing evidence that alterations in lower extremity biomechanical factors during weight bearing activities, such as, alterations in movement and muscle activity patterns, ground reaction forces, and lower ..
  11. In vivo ACL Reconstruction Biomechanics
    Guoan Li; Fiscal Year: 2010
    ....
  12. Neural Mechanisms Underlying Acupuncture Analgesia
    Jin Chung; Fiscal Year: 2007
    ..This is shown by the finding the EA results in about 40% recovery of weight bearing by the hind limb with ankle sprain...
  13. Neural Mechanisms Underlying Acupuncture Analgesia
    Jin Chung; Fiscal Year: 2004
    ..This is shown by the finding that EA results in about 40% recovery of weight bearing by the hind limb with ankle sprain...
  14. Mechanical Intervention in Children with Cerebral Palsy
    Tishya Wren; Fiscal Year: 2005
    ..These subjects will undergo an additional 6 months of weight bearing without vibration following the same schedule to serve as an internal control...
  15. Anterior Cruciate Ligament Reconstruction and the Initiation of Osteoarthritis
    Thomas P Andriacchi; Fiscal Year: 2010
    ..2.) To determine if there are detectable thickness changes in the weight bearing regions of tibiofemoral cartilage over a 2 year period following ACL reconstruction that are greater than a ..
  16. ActiveImplant Prosthesis for Lower Limb Amputees
    JOHN FAGO; Fiscal Year: 2007
    ..distal femur above the knee do not provide an optimum solution for interfacing with a prosthetic socket for weight bearing and ambulation...
  17. Enhanced Clinical Diagnosis of Early Osteoarthritis
    Constance R Chu; Fiscal Year: 2010
    ..2) To test the hypothesis that OCT detectable microstructural damage is prevalent in grossly normal appearing weight bearing cartilage of human subjects undergoing arthroscopy to treat degenerative meniscal tears...
  18. Shoulder Pain in Spinal Cord Injury (SCI): A Longitudinal Study
    Sara J Mulroy; Fiscal Year: 2010
    ..Chronic shoulder pain after SCI has been associated with the repetitive weight bearing of wheelchair propulsion (WCP), but a causal relationship has not been established...
  19. Shoulder Pain in Spinal Cord Injury (SCI): A Longitudinal Study
    Sara Mulroy; Fiscal Year: 2009
    ..Chronic shoulder pain after SCI has been associated with the repetitive weight bearing of wheelchair propulsion (WCP), but a causal relationship has not been established...
  20. Shoulder Pain in Spinal Cord Injury (SCI): A Longitudinal Study
    Sara Mulroy; Fiscal Year: 2009
    ..Chronic shoulder pain after SCI has been associated with the repetitive weight bearing of wheelchair propulsion (WCP), but a causal relationship has not been established...
  21. Enhanced Clinical Diagnosis of Early Osteoarthritis
    Constance Chu; Fiscal Year: 2007
    ..2) To test the hypothesis that OCT detectable microstructural damage is prevalent in grossly normal appearing weight bearing cartilage of human subjects undergoing arthroscopy to treat degenerative meniscal tears...
  22. AGGRECAN-hG1 AND LP TRANSGENIC MICE AS MODELS OF OSTEOARTHRITIS (OA)
    Tibor Glant; Fiscal Year: 2007
    ..Transgenic animals overexpressing G1 domain and LP will be intercrossed to create double transgenic mice, possibly simulating various degrees of aging and/or osteoarthritic processes. ..
  23. Shoulder Pain in Spinal Cord Injury (SCI): A Longitudinal Study
    Sara Mulroy; Fiscal Year: 2007
    ..Chronic shoulder pain after SCI has been associated with the repetitive weight bearing of wheelchair propulsion (WCP), but a causal relationship has not been established...
  24. ALTERED MECHANICAL LOADS AND SKELETAL MUSCLE PHENOTYPE
    Richard Tsika; Fiscal Year: 2009
    ..little is known about how the integrative biological response to decreased mechanical loading [hindlimb non-weight bearing (NWB)] leads to fiber-type shifts and altered transcriptional regulation of MyHC genes...
  25. Acetaminophen and Impaired Musculoskeletal Adaptations to Exercise Training
    CATHERINE JANKOWSKI; Fiscal Year: 2007
    ....