mechanics

Summary

Summary: The branch of physics which deals with the motions of material bodies, including kinematics, dynamics, and statics. When the laws of mechanics are applied to living structures, as to the locomotor system, it is referred to as BIOMECHANICS. (From Dorland, 28th ed)

Top Publications

  1. pmc The differential role of motor cortex in stretch reflex modulation induced by changes in environmental mechanics and verbal instruction
    Jonathan Shemmell
    Sensory Motor Performance Program, The Rehabilitation Institute of Chicago, Chicago, Illinois 60611, USA
    J Neurosci 29:13255-63. 2009
  2. doi Thermodynamics and mechanics of membrane curvature generation and sensing by proteins and lipids
    Tobias Baumgart
    Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Annu Rev Phys Chem 62:483-506. 2011
  3. ncbi Equilibrium regained: from nonequilibrium chaos to statistical mechanics
    D A Egolf
    Center for Nonlinear Studies MS B258, Theoretical Division and Condensed Matter and Thermal Physics, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    Science 287:101-4. 2000
  4. pmc A discrete model to study reaction-diffusion-mechanics systems
    Louis D Weise
    Department of Theoretical Biology, Utrecht University, Utrecht, The Netherlands
    PLoS ONE 6:e21934. 2011
  5. pmc Structural hierarchy governs fibrin gel mechanics
    Izabela K Piechocka
    Biological Soft Matter Group, Foundation for Fundamental Research on Matter, Institute for Atomic and Molecular Physics, Amsterdam, The Netherlands
    Biophys J 98:2281-9. 2010
  6. ncbi Theoretical mechanics: crowd synchrony on the Millennium Bridge
    Steven H Strogatz
    Department of Theoretical and Applied Mechanics, Cornell University, Ithaca, New York 14853 1503, USA
    Nature 438:43-4. 2005
  7. ncbi Mechanics of airflow in the human nasal airways
    D J Doorly
    Department of Aeronautics, Imperial College London, Exhibition Road, London SW7 2AZ, UK
    Respir Physiol Neurobiol 163:100-10. 2008
  8. ncbi Mechanics of the taper integrated screwed-in (TIS) abutments used in dental implants
    Dincer Bozkaya
    Department of Mechanical Engineering, Northeastern University, 334 Snell engineering, Boston, MA 02115, USA
    J Biomech 38:87-97. 2005
  9. pmc Molecular mechanics of filamin's rod domain
    Kevin S Kolahi
    Molecular Cell Biomechanics Laboratory, Department of Bioengineering and Biophysics Graduate Group, University of California, Berkeley, California 94720, USA
    Biophys J 94:1075-83. 2008
  10. pmc More than a monolayer: relating lung surfactant structure and mechanics to composition
    Coralie Alonso
    Department of Chemical Engineering and Materials, University of California, Santa Barbara, California 93106 5080, USA
    Biophys J 87:4188-202. 2004

Research Grants

  1. Biomedical Simulations Resource (BMSR)
    DAVID Z D apos ARGENIO; Fiscal Year: 2010
  2. Biomedical Simulations Resource (BMSR)
    DAVID D ARGENIO; Fiscal Year: 2009
  3. Observing Auditory Mechanics with Pressure and Motion
    Elizabeth Olson; Fiscal Year: 2003
  4. Ty3 viruslike particle morphogenesis and host interactions
    Suzanne Sandmeyer; Fiscal Year: 2010
  5. Mechanisms of Therapeutic Action in SCI
    Mehdi M Mirbagheri; Fiscal Year: 2010
  6. Mechanisms of Therapeutic Action in SCI
    MEHDI MIRBAGHERI; Fiscal Year: 2009
  7. OBSERVING AUDITORY MECHANICS WITH PRESSURE MEASUREMENTS
    Elizabeth Olson; Fiscal Year: 2001
  8. OBSERVING AUDITORY MECHANICS WITH PRESSURE MEASUREMENTS
    Elizabeth Olson; Fiscal Year: 2001
  9. OBSERVING AUDITORY MECHANICS WITH PRESSURE MEASUREMENTS
    Elizabeth Olson; Fiscal Year: 2005
  10. OBSERVING AUDITORY MECHANICS WITH PRESSURE MEASUREMENTS
    Elizabeth Olson; Fiscal Year: 2002

Detail Information

Publications216 found, 100 shown here

  1. pmc The differential role of motor cortex in stretch reflex modulation induced by changes in environmental mechanics and verbal instruction
    Jonathan Shemmell
    Sensory Motor Performance Program, The Rehabilitation Institute of Chicago, Chicago, Illinois 60611, USA
    J Neurosci 29:13255-63. 2009
    ..These results demonstrate that task-dependent changes in reflex function can be mediated through multiple neural pathways and that these pathways have task-specific roles...
  2. doi Thermodynamics and mechanics of membrane curvature generation and sensing by proteins and lipids
    Tobias Baumgart
    Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Annu Rev Phys Chem 62:483-506. 2011
    ..Finally, we discuss relatively simple thermodynamic/mechanical models that allow quantitative interpretation of experimental observations...
  3. ncbi Equilibrium regained: from nonequilibrium chaos to statistical mechanics
    D A Egolf
    Center for Nonlinear Studies MS B258, Theoretical Division and Condensed Matter and Thermal Physics, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    Science 287:101-4. 2000
    ..such as Gibbs distributions and detailed balance are recovered at these scales, which suggests that the macroscopic behavior of some far-from-equilibrium systems might be understood in terms of equilibrium statistical mechanics.
  4. pmc A discrete model to study reaction-diffusion-mechanics systems
    Louis D Weise
    Department of Theoretical Biology, Utrecht University, Utrecht, The Netherlands
    PLoS ONE 6:e21934. 2011
    This article introduces a discrete reaction-diffusion-mechanics (dRDM) model to study the effects of deformation on reaction-diffusion (RD) processes...
  5. pmc Structural hierarchy governs fibrin gel mechanics
    Izabela K Piechocka
    Biological Soft Matter Group, Foundation for Fundamental Research on Matter, Institute for Atomic and Molecular Physics, Amsterdam, The Netherlands
    Biophys J 98:2281-9. 2010
    ..Moreover, in contrast with other biopolymers, fibrin fibers intrinsically stiffen when stretched. The resulting hierarchy of elastic regimes explains the incredible resilience of fibrin clots against large deformations...
  6. ncbi Theoretical mechanics: crowd synchrony on the Millennium Bridge
    Steven H Strogatz
    Department of Theoretical and Applied Mechanics, Cornell University, Ithaca, New York 14853 1503, USA
    Nature 438:43-4. 2005
    ..Our approach should help engineers to estimate the damping needed to stabilize other exceptionally crowded footbridges against synchronous lateral excitation by pedestrians...
  7. ncbi Mechanics of airflow in the human nasal airways
    D J Doorly
    Department of Aeronautics, Imperial College London, Exhibition Road, London SW7 2AZ, UK
    Respir Physiol Neurobiol 163:100-10. 2008
    The mechanics of airflow in the human nasal airways is reviewed, drawing on the findings of experimental and computational model studies...
  8. ncbi Mechanics of the taper integrated screwed-in (TIS) abutments used in dental implants
    Dincer Bozkaya
    Department of Mechanical Engineering, Northeastern University, 334 Snell engineering, Boston, MA 02115, USA
    J Biomech 38:87-97. 2005
    ..tightening and loosening torque values by combining the equations related to the tapered interface with screw mechanics equations...
  9. pmc Molecular mechanics of filamin's rod domain
    Kevin S Kolahi
    Molecular Cell Biomechanics Laboratory, Department of Bioengineering and Biophysics Graduate Group, University of California, Berkeley, California 94720, USA
    Biophys J 94:1075-83. 2008
    ..Actin-binding proteins, e.g., filamin, can naturally contribute to the mechanics and function of the actin cytoskeleton...
  10. pmc More than a monolayer: relating lung surfactant structure and mechanics to composition
    Coralie Alonso
    Department of Chemical Engineering and Materials, University of California, Santa Barbara, California 93106 5080, USA
    Biophys J 87:4188-202. 2004
    ..The high viscosity may lead to high monolayer collapse pressures, help prevent atelectasis, and minimize the flow of lung surfactant out of the alveoli due to surface tension gradients...
  11. doi Understanding molecular structure from molecular mechanics
    Norman L Allinger
    Department of Chemistry, Chemistry Annex, University of Georgia, Athens, GA 30602
    J Comput Aided Mol Des 25:295-316. 2011
    Molecular mechanics gives us a well known model of molecular structure. It is less widely recognized that valence bond theory gives us structures which offer a direct interpretation of molecular mechanics formulations and parameters...
  12. pmc DNA mechanics as a tool to probe helicase and translocase activity
    Timothee Lionnet
    Laboratoire de Physique Statistique de l Ecole Normale Superieure, UMR 8550 CNRS, 24 rue Lhomond, 75231 Paris Cedex 05, France
    Nucleic Acids Res 34:4232-44. 2006
    ..We then discuss experiments on two dsDNA translocases: the RuvAB motor studied on its natural substrate, the Holliday junction, and the chromosome-segregation motor FtsK, showing its unusual coupling to DNA supercoiling...
  13. ncbi In-vivo implant mechanics of flexible, silicon-based ACREO microelectrode arrays in rat cerebral cortex
    Winnie Jensen
    Center for Sensory Motor Interaction, Department of Health Science, Aalborg University, 9220 Aalborg, Denmark
    IEEE Trans Biomed Eng 53:934-40. 2006
    ..The objective of the present work was to investigate the in vivo implant mechanics of flexible, silicon-based ACREO microelectrode arrays recently developed by the VSAMUEL consortium (European ..
  14. pmc Cadherin mechanics and complexation: the importance of calcium binding
    Fabien Cailliez
    Laboratoire de Biochimie Theorique, CNRS, UPR 9080, Institut de Biologie Physico Chimique, Paris 75005, France
    Biophys J 89:3895-903. 2005
    ..Here again, it is shown that the presence of calcium is an important factor in both rigidifying and stabilizing the complex...
  15. pmc A multiscale red blood cell model with accurate mechanics, rheology, and dynamics
    Dmitry A Fedosov
    Division of Applied Mathematics, Brown University, Providence, Rhode Island, USA
    Biophys J 98:2215-25. 2010
    ..We present a multiscale RBC model that is able to predict RBC mechanics, rheology, and dynamics in agreement with experiments...
  16. ncbi Fluid mechanics of electroosmotic flow and its effect on band broadening in capillary electrophoresis
    Sandip Ghosal
    Department of Mechanical Engineering, Northwestern University, Evanston, IL 60208, USA
    Electrophoresis 25:214-28. 2004
    ..In this paper, the basic facts about EOF are reviewed from the perspective of fluid mechanics and its effect on separations in free solution capillary zone electrophoresis is discussed in the light of ..
  17. ncbi A novel quantitative approach for evaluating contact mechanics of meniscal replacements
    E Linder-Ganz
    Research and Development Center, Active Implants Corporation, Netanya, 42505 Israel
    J Biomech Eng 132:024501. 2010
    ....
  18. ncbi A micro-mechanics model of dentin mechanical properties
    Qing Hua Qin
    Department of Mechanics, Tianjin University, Tianjin 300072, China
    Biomaterials 25:5081-90. 2004
    Application of a micro-mechanics cell model to dentin composites for determination of their effective mechanical properties is discussed in this paper...
  19. pmc Neutrophil-bead collision assay: pharmacologically induced changes in membrane mechanics regulate the PSGL-1/P-selectin adhesion lifetime
    K E Edmondson
    Institute for Medicine and Engineering, Department of Bioengineering, University of Pennsylvania, 3320 Smith Walk, Philadelphia, PA 19104, USA
    Biophys J 89:3603-14. 2005
    ..Membrane tether growth can be enhanced or reduced pharmacologically with consequent effects on PSGL-1/P-selectin lifetimes...
  20. pmc Prediction of the translocation kinetics of a protein from its mechanical properties
    Daniel K West
    School of Physics and Astronomy, University of Leeds, Leeds LS2 9JT, United Kingdom
    Biophys J 91:L51-3. 2006
    ....
  21. pmc Single-molecule force spectroscopy reveals a mechanically stable protein fold and the rational tuning of its mechanical stability
    Deepak Sharma
    Department of Chemistry, University of British Columbia, Vancouver, BC, Canada
    Proc Natl Acad Sci U S A 104:9278-83. 2007
    ....
  22. ncbi Mechanics of coracoacromial ligament transfer augmentation for acromioclavicular joint injuries
    David R Wilson
    Orthopaedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, USA
    J Biomech 38:615-9. 2005
    ..107). We anticipate that, when surgery is indicated for treating acromioclavicular joint injury, an augmented Weaver-Dunn reconstruction will yield a joint that is less painful, more functional and less likely to require revision...
  23. ncbi Mechanical unfolding of proteins: insights into biology, structure and folding
    Julia R Forman
    Cambridge University Department of Chemistry, MRC Centre for Protein Engineering, Lensfield Road, Cambridge CB2 1EW, UK
    Curr Opin Struct Biol 17:58-66. 2007
    ..Finally, recent technological developments offer exciting new avenues for experimental studies...
  24. pmc Nonlinear mechanics of soft fibrous networks
    A Kabla
    Division of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA
    J R Soc Interface 4:99-106. 2007
    ..A simple microscopic model allows us to explain these features of our observations, and provides us with a baseline framework to understand active biomechanical networks...
  25. ncbi Wind-induced dust generation and transport mechanics on a bare agricultural field
    Ted M Zobeck
    Wind Erosion and Water Conservation Research Unit, USDA, Agricultural Research Service, 3810 4th Street Lubbock, TX 79415, USA
    J Hazard Mater 132:26-38. 2006
    ..established by the United States Environmental Protection Agency, information on dust generation and transport mechanics is needed to determine the particulate hazard of dust sources...
  26. ncbi Tibiofemoral contact mechanics after serial medial meniscectomies in the human cadaveric knee
    Stephen J Lee
    The Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Am J Sports Med 34:1334-44. 2006
    There is no consensus regarding the extent of meniscectomy leading to deleterious effects on tibiofemoral contact mechanics.
  27. ncbi Scale relativity theory and integrative systems biology: 2. Macroscopic quantum-type mechanics
    Laurent Nottale
    LUTH, CNRS, Observatoire de Paris and Paris Diderot University Paris VII, 5 place Jules Janssen, 92190 Meudon, France
    Prog Biophys Mol Biol 97:115-57. 2008
    ....
  28. pmc Molecular mechanics calculations on Rous sarcoma virus protease with peptide substrates
    I T Weber
    Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Protein Sci 6:2365-74. 1997
    ..56 for all substrates. These results are compared to those from similar calculations on HIV-1 protease and discussed in relation to the rate-limiting steps in the catalytic mechanism and the entropic contributions...
  29. ncbi Molecular mechanics methods for predicting protein-ligand binding
    Niu Huang
    Department of Pharmaceutical Chemistry, University of California San Francisco, UCSF MC 2240, Genentech Hall, Room N472C, 600 16th St, San Francisco, CA 94158 2517, USA
    Phys Chem Chem Phys 8:5166-77. 2006
    ..We provide an overview of recent work using molecular mechanics energy functions to address this challenge...
  30. ncbi Intelligence by mechanics
    Reinhard Blickhan
    Motion Science, Seidelstrasse 20, Institute of Sport Science, Friedrich Schiller University Jena, 07749 Jena, Germany
    Philos Trans A Math Phys Eng Sci 365:199-220. 2007
    ..To ensure secure foothold visco-elastic suspended muscles serve as shock absorbers. Experiments with technically implemented leg models, which explore some of these principles, are promising...
  31. ncbi Statistical mechanics of base stacking and pairing in DNA melting
    Vassili Ivanov
    Department of Physics and Astronomy, University of California Los Angeles, Los Angeles, CA 90095 1547, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 70:051907. 2004
    We propose a statistical mechanics model for DNA melting in which base stacking and pairing are explicitly introduced as distinct degrees of freedom...
  32. ncbi Experimental and computational approach for evaluating the mechanical characteristics of dental composite resins with various filler sizes
    Yasuhiro Tanimoto
    Department of Dental Biomaterials, Nihon University School of Dentistry at Matsudo, 2 870 1 Sakaecho nishi, Matsudo, Chiba 271 8587, Japan
    Acta Biomater 2:633-9. 2006
    ..In addition, FE analysis was effective for evaluating stress distributions of dental composite resins with various filler sizes...
  33. ncbi Influence of a pre-blended antibiotic (gentamicin sulfate powder) on various mechanical, thermal, and physical properties of three acrylic bone cements
    Gladius Lewis
    Department of Mechanical Engineering, The University of Memphis, Memphis, Tennessee 38152, USA
    J Biomater Appl 20:377-408. 2006
    ....
  34. pmc Design of biomimetic fibrillar interfaces: 2. Mechanics of enhanced adhesion
    C Y Hui
    Department of Theoretical and Applied Mechanics, Cornell University, 212 Kimball Hall, Ithaca, NY 14853, USA
    J R Soc Interface 1:35-48. 2004
    ..We obtain the practical work of adhesion for an idealized fibrillated interface under equal load sharing. We then analyse the peeling of a fibrillar surface from a rigid substrate and establish a criterion for ELS...
  35. ncbi Mechanical properties and cellular proliferation of electrospun collagen type II
    Kelly J Shields
    Orthopedic Research Laboratory, Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, Virginia 23298 0694, USA
    Tissue Eng 10:1510-7. 2004
    ..Electrospun collagen type II scaffolds produce a suitable environment for chondrocyte growth, which potentially establishes the foundation for the development of articular cartilage repair...
  36. ncbi Mechanical properties of cast Ti-Hf alloys
    Hideki Sato
    Division of Operative Dentistry, Graduate School of Dentistry, Tohoku University, 4 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    J Biomed Mater Res B Appl Biomater 72:362-7. 2005
    ..05) lower than that of the pure Ti. The cast Ti-Hf alloys tested can be considered viable alternatives to CP Ti because they were stronger than CP Ti and had similar elongation...
  37. ncbi High maneuverability guidewire with functionally graded properties using new superelastic alloys
    Y Sutou
    Tohoku University Biomedical Engineering Research Organization, TUBERO Aobayama Material Science Branch, Sendai, Japan
    Minim Invasive Ther Allied Technol 15:204-8. 2006
    ..Moreover, a metallic catheter using a Ni-free Ti-based SMA with high biocompatibility is introduced...
  38. ncbi Structural and mechanical study of a self-assembling protein nanotube
    J F Graveland-Bikker
    NIZO Food Research, P O Box 20, 6710 BA Ede, The Netherlands
    Nano Lett 6:616-21. 2006
    ....
  39. ncbi Thermomechanical investigation of the cortical bone analogue in third-generation Sawbones femurs
    C G R Bell
    School of Engineering Systems, Queensland University of Technology, GPO Box 2434, Brisbane, Queensland 4001, Australia
    Proc Inst Mech Eng H 221:213-7. 2007
    ..SGFR epoxy Sawbones do not accurately represent the material properties of bone at body temperature...
  40. ncbi Numerical method to determine mechanical parameters of engineering design in rock masses
    Ting He Xue
    Traffic Engineering Institute, Zhejiang University, Hangzhou 310027, China
    J Zhejiang Univ Sci 5:884-9. 2004
    ..This method can be used to evaluate the mechanics of every kind of medium; and is a new way to determine the mechanical parameters used in engineering design in ..
  41. ncbi In-vitro investigation on suitability of light-cured resins for interocclusal splints : part II: surface hardness
    Gholamreza Danesh
    Department of Orthodontics and Dentofacial Orthopedics, University of Munster, Munster, Germany
    J Orofac Orthop 67:138-47. 2006
    ..The aim of the present study was to determine the surface hardness of light- and auto-cured resins for the fabrication of occlusal splints employing Vickers hardness measurements...
  42. ncbi Measurement of the bending strength of vapor-liquid-solid grown silicon nanowires
    Samuel Hoffmann
    EMPA Materials Science and Technology, Feuerwerkerstrasse 39, 3602 Thun, Switzerland
    Nano Lett 6:622-5. 2006
    ..This value is close to the theoretical fracture strength, which indicates that surface or volume defects, if present, play only a minor role in fracture initiation...
  43. ncbi Mechanically tunable three-dimensional elastomeric network/air structures via interference lithography
    Ji Hyun Jang
    Institute for Soldier Nanotechnologies, Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nano Lett 6:740-3. 2006
    ..Brillouin light scattering (BLS) was employed to measure phononic modes of the structure as a function of mechanical strain. The results demonstrate that the phononic band diagram of such structures can be tuned mechanically...
  44. ncbi Remote sensing of mechanical properties of materials using a novel ultrasound transducer and signal processing
    Yoshinobu Murayama
    College of Engineering, Nihon University, Koriyama, Fukushima 963 8642, Japan
    IEEE Trans Ultrason Ferroelectr Freq Control 52:439-44. 2005
    ..Such measurements obviate the need to apply the force-deformation approach and may be used to enable stiffness imaging...
  45. ncbi [In vitro elution and mechanical properties of antibiotic-loaded SmartSet HV and Palacos R acrylic bone cements]
    P M S Simpson
    Department of Orthopaedics, University of Edinburgh, New Royal Infirmary, Edinburgh, UK
    Orthopade 34:1255-62. 2005
    ..An in vitro antibiotic elution and mechanical study was therefore carried out to compare a newer bone cement, SmartSet, with the established Palacos R cement...
  46. ncbi The mechanical integrity of in vivo engineered heterotopic bone
    Patrick H Warnke
    Department of Oral and Maxillofacial Surgery, University of Kiel, Arnold Heller Str 16, 24 105 Kiel, Germany
    Biomaterials 27:1081-7. 2006
    ..This differed significantly from the much lower compression resistance seen in the unadulterated BioOss [0.92 MPa (SD+/-0.04)]. Following this, the in vivo engineered bone has a similar mechanical compression stability as natural bone...
  47. ncbi The role of interfacial mechanics in the prediction of global mechanical behavior of a bioactive composite: an in vitro study
    Emily Ho
    Materials Science and Engineering Department at Drexel University, Philadelphia, PA, USA
    J Oral Implantol 32:63-71. 2006
    ..Thus, nano-indentation is a sensitive technique for examining interfacial mechanics and mechanical consequences of biologic reactivity of composite materials.
  48. ncbi Mechanical properties of carbon nanotubes and their polymer nanocomposites
    Hiroaki Miyagawa
    School of Packaging, Michigan State University, East Lansing, MI 48824 1223, USA
    J Nanosci Nanotechnol 5:1593-615. 2005
    ..Thirdly, fracture and fatigue properties of CNT/polymer nanocomposites are reviewed, since these properties are important, especially when these new nanocomposite materials are applied for structural applications...
  49. ncbi Mechanical properties of continuously spun fibers of carbon nanotubes
    Marcelo Motta
    Department of Materials Science and Metallurgy, University of Cambridge, Pembroke Street, Cambridge CB2 3QZ, UK
    Nano Lett 5:1529-33. 2005
    ..46 GPa (equivalent to 0.70 N/tex assuming a density of 2.1 g/cm(3)). The experiments indicate that significant improvements in the mechanical properties can be accomplished by optimizing the process conditions...
  50. ncbi 3D fiber-deposited scaffolds for tissue engineering: influence of pores geometry and architecture on dynamic mechanical properties
    L Moroni
    Institute for Biomedical Technology, University of Twente, P O Box 217, 7500 AE Enschede, The Netherlands
    Biomaterials 27:974-85. 2006
    ..This investigation showed that viscoelastic properties of 3DF scaffolds could be modulated to accomplish mechanical requirements for tailored tissue engineered applications...
  51. ncbi Mechanical properties of two orthodontic adhesive materials polymerized with halogen and plasma curing
    S Mifsud
    LEIBO, Faculté d Odontologie de Lyon, France
    Biomed Mater Eng 15:269-77. 2005
    ....
  52. ncbi Mechanics of curved plasma membrane vesicles: resting shapes, membrane curvature, and in-plane shear elasticity
    Tadashi Kosawada
    Department of Mechanical Systems Engineering, Yamagata University, Jonan 4 3 16, Yonezawa 992 8510, Japan
    J Biomech Eng 127:229-36. 2005
    ..To enhance our understanding of plasmalemmal vesicles we need to improve the understanding of the mechanics in regions of high membrane curvatures...
  53. ncbi Nanomechanics of silicon surfaces with atomic force microscopy: an insight to the first stages of plastic deformation
    Sergi Garcia-Manyes
    Center for Bioengineering of Catalonia CREBEC and Department of Physical Chemistry, University of Barcelona, Spain
    J Chem Phys 123:114711. 2005
    ..Hardness measurements with penetration depths as small as 1 nm yield H= approximately 25 GPa, thus showing a drastic increase with penetration depths below 5 nm...
  54. ncbi Are scaling laws on strength of solids related to mechanics or to geometry?
    Alberto Carpinteri
    Politecnico di Torino, Department of Structural Engineering and Geotechnics, Corso Duca degli Abruzzi 24, 10129 Torino, Italy
    Nat Mater 4:421-3. 2005
    ..In spite of the prevailing view, which considers mechanics as the real cause of such effects, here, we propose a different argument, purely based on geometry...
  55. ncbi Mechanical testing of isolated amorphous silicon slanted nanorods
    C Gaire
    Department of Physics, Applied Physics and Astronomy, Rensselaer Polytechnic Institute, Troy, New York 12180 3590, USA
    J Nanosci Nanotechnol 5:1893-7. 2005
    ..14 +/- 10.21) GPa. No size effect of this parameter was observed within the accuracy of the present measurement...
  56. ncbi Photomechanical actuation in polymer-nanotube composites
    Samit V Ahir
    Cavendish Laboratory, University of Cambridge, Cambridge CB3 0HE, UK
    Nat Mater 4:491-5. 2005
    ..It is thought that no other materials can display this continuously reversible response of so large a magnitude, making rubber nanocomposites important for actuator applications...
  57. pmc Nano measurements with micro-devices: mechanical properties of hydrated collagen fibrils
    S J Eppell
    Case Western Reserve University, Department of Biomedical Engineering, Cleveland, OH 44106, USA
    J R Soc Interface 3:117-21. 2006
    ..We used the device to obtain the first stress-strain curve of an isolated collagen fibril producing the modulus and some fatigue properties of this soft nanofibril...
  58. ncbi Mechanically mediated electron transfer in model metallo-enzyme interfaces
    L Yu Gorelik
    Department of Applied Physics, Chalmers University of Technology, 412 96 Goteborg, Sweden
    Biosens Bioelectron 22:405-8. 2006
    ..In this paper we will focus on a special type of nanoelectro-mechanical processes in this system and investigate single electronic effects in there...
  59. ncbi Effect of polymorphism of SiO2 addition on mechanical properties of Feldspathic porcelains
    Ryo Tokunaga
    General Dentistry Department of Comprehensive Oral Health Care, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8549, Japan
    Dent Mater J 27:347-55. 2008
    ..Circumferential cracks were observed in the porcelains with cristobalite. These results suggested that cristobalite could strengthen fracture toughness of feldspathic porcelains, but not flexural strength...
  60. ncbi Macroscopic tuning of nanomechanics: substrate bending for reversible control of frequency and quality factor of nanostring resonators
    Scott S Verbridge
    Department of Physics and the Cornell Center for Materials Research, Cornell University, Ithaca, New York 14853, USA
    Nano Lett 7:1728-35. 2007
    ....
  61. ncbi In vivo biocompatibility and mechanical properties of porous zein scaffolds
    Hua Jie Wang
    College of Life Science and Biotechnology, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China
    Biomaterials 28:3952-64. 2007
    ....
  62. ncbi Porous polymer/bioactive glass composites for soft-to-hard tissue interfaces
    Kai Zhang
    Department of Chemical Engineering and Materials Science, University of Minnesota, 421 Washington Avenue SE, Minneapolis, Minnesota 55455, USA
    J Biomed Mater Res 61:551-63. 2002
    ..Composite modulus and break strength increased with increasing glass content due to the change in composition and pore content...
  63. ncbi Glassy photomechanical liquid-crystal network actuators for microscale devices
    C L van Oosten
    Department of Chemistry and Chemical Engineering, Technische Universiteit Eindhoven, Postbus 513, 5600 MB Eindhoven, The Netherlands
    Eur Phys J E Soft Matter 23:329-36. 2007
    ..The bending radii of these systems are predicted using a simple model including effects of light intensity, material composition and actuator thickness...
  64. ncbi Nanomechanical investigation of Mo6S9-x Ix nanowire bundles
    Andras Kis
    Institut de la Physique de la Matière Complexe, EPFL, Lausanne, Switzerland
    Small 3:1544-8. 2007
  65. ncbi Nanomechanical characterization of one-step combustion-synthesized Al(4)B(2)O(9) and Al(18)B(4)O(33) nanowires
    Xinyong Tao
    Department of Mechanical Engineering, University of South Carolina, 300 Main Street, Columbia, South Carolina 29208, USA
    Nano Lett 7:3172-6. 2007
    ..A 70% reduction in elastic modulus was found in Al(18)B(4)O(33) nanowires compared with their bulk counterpart. Al(18)B(4)O(33) nanowires exhibited higher hardness and elastic modulus than Al(4)B(2)O(9) nanowires...
  66. ncbi Novel method for mechanical characterization of polymeric nanofibers
    Mohammad Naraghi
    Aerospace Engineering, University of Illinois at Urbana Champaign, 325 Talbot Lab, Urbana, IL 61801, USA
    Rev Sci Instrum 78:085108. 2007
    ..6+/-1.5 GPa and large irreversible strains that exceeded 220%. The large fiber stretch ratios were the result of a cascade of periodic necks that formed during cold drawing of the nanofibers...
  67. ncbi Spider silk fibers spun from soluble recombinant silk produced in mammalian cells
    Anthoula Lazaris
    Nexia Biotechnologies, Vaudreuil Dorion, Quebec J7V 8P5, Canada
    Science 295:472-6. 2002
    ..Fiber properties correlated with finer fiber diameter and increased birefringence...
  68. ncbi Effect of novel filler particles on the mechanical and wear properties of dental composites
    D E Ruddell
    Curriculum in Applied and Materials Sciences, University of North Carolina, Chapel Hill, NC, USA
    Dent Mater 18:72-80. 2002
    ..The purpose of this study was to investigate the method of producing pre-polymerized fused-fiber filler modified composite (PP-FFMC) particles and the effectiveness of incorporating these novel filler particles into dental composites...
  69. ncbi Thermomechanical analysis of ultra-high molecular weight polyethylene-metal hip prostheses
    M Rocchi
    Laboratorio di Tecnologia Medica, Istituti Ortopedici Rizzoli, Bologna, Italy
    Proc Inst Mech Eng H 221:561-8. 2007
    ..The full coupling between the thermal and the mechanical conditions used in this study appears to be necessary if accurate predictions of the polyethylene deformation are required...
  70. ncbi An instrument for environmental control of vapor pressure and temperature for tensile creep and other mechanical property measurements
    P W Majsztrik
    Chemistry Department, Princeton University, Princeton, New Jersey 08544, USA
    Rev Sci Instrum 78:103904. 2007
    ..The main features of the instrument are presented along with experimental methodology and analysis of results. The adaptation of the instrument to other mechanical tests is briefly described...
  71. ncbi Unique mechanical properties of nanostructured metals
    Nobuhiro Tsuji
    Department of Adaptive Machine Systems, Osaka University, Suita 565 0871, Japan
    J Nanosci Nanotechnol 7:3765-70. 2007
    ..The unique properties seem to be attributed to the characteristic structures of the nano-metals full of grain boundaries...
  72. doi Peeling force spectroscopy: exposing the adhesive nanomechanics of one-dimensional nanostructures
    M C Strus
    School of Mechanical Engineering and Birck Nanotechnology Center, Purdue University, West Lafayette, Indiana, USA
    Nano Lett 8:544-50. 2008
    ..This opens up the possibility of quantitative comparison and control of adhesion between nanotubes or nanowires on different substrates...
  73. ncbi Thermal and thermomechanical properties of poly(butylene succinate) nanocomposites
    Mamookho E Makhatha
    National Centre for Nanostructured Materials, Council for Scientific and Industrial Research, Pretoria 0001, PO Box 395, Republic of South Africa
    J Nanosci Nanotechnol 8:1679-89. 2008
    ..In the nitrogen environment, however, the thermal stability systematically decreases with increasing clay loading...
  74. ncbi Suspended mechanical structures based on elastic silicon nanowire arrays
    Alvaro San Paulo
    Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, California 94720, USA
    Nano Lett 7:1100-4. 2007
    ..Our results point out important differences in the morphology and mechanical behavior of the fabricated nanowire-based structures with respect to equivalent bulk material structures...
  75. ncbi Effects of fibronectin and laminin on structural, mechanical and transport properties of 3D collageneous network
    D Guarnieri
    Interdisciplinary Centre of Biomedical Materials CRIB, University of Naples Federico II, P le Tecchio 80, Naples, Italy
    J Mater Sci Mater Med 18:245-53. 2007
    ..In addition, high FN and LM concentrations affected collagen fibre assembly and structure and induced drastic effects on rheological and transport properties...
  76. ncbi Electronic, thermal and mechanical properties of carbon nanotubes
    M S Dresselhaus
    Department of Physics and Department of Electrical Engineering and Computer Science, Massachussetts Institute of Technology, Cambridge, MA 02139 4307, USA
    Philos Transact A Math Phys Eng Sci 362:2065-98. 2004
    ..Both experimental and theoretical aspects of these topics are reviewed...
  77. ncbi Progress on mechanics of carbon nanotubes and derived materials
    Jean Paul Salvetat
    CNRS, Centre de Recherche sur la Matiere Divisee, UMR6619, Orleans, France
    J Nanosci Nanotechnol 6:1857-82. 2006
    ..Nanotube surface engineering combined with methods producing oriented nanocomposites should bring exceptional materials in the near future...
  78. ncbi Complex buckling instability patterns of nanomembranes with encapsulated gold nanoparticle arrays
    Chaoyang Jiang
    Department of Materials Science and Engineering, Iowa State University, Ames, Iowa 50011, USA
    Nano Lett 6:2254-9. 2006
    ..The binary buckling pattern observed here allowed the "one-shot" evaluation of the elastic moduli of two compositionally different regions (with and without gold nanoparticles)...
  79. ncbi Size effects on the mechanical behavior of nanoporous Au
    Juergen Biener
    Nanoscale Synthesis and Characterization Laboratory, Lawrence Livermore National Laboratory, P O Box 808, L 367, Livermore, California 94550, USA
    Nano Lett 6:2379-82. 2006
    ..We find that nanoporous gold can be as strong as bulk Au, despite being a highly porous material, and that the ligaments in nanoporous gold approach the theoretical yield strength of Au...
  80. ncbi Mechanics of patterned helical Si springs on Si substrate
    D L Liu
    Department of Physics, Applied Physics, and Astronomy, Rensselaer Polytechnic Institute, Troy, New York, USA
    J Nanosci Nanotechnol 3:492-5. 2003
    ....
  81. ncbi Dramatic effect of dispersed carbon nanotubes on the mechanical and electroconductive properties of polymers derived from ionic liquids
    Takanori Fukushima
    Aida Nanospace Project, ERATO SORST Japan Science and Technology Agency, National Museum of Emerging Science and Innovation, 2 41 Aomi, Koto ku, Tokyo 135 0064, Japan
    Small 2:554-60. 2006
    ..Although a bucky plastic derived from a vinylimidazolium ion-based ionic liquid monomer shows a comparable conductivity to that of the methacrylate version, the film is brittle irrespective of the presence or absence of SWNTs...
  82. ncbi Design of braided composite cardiovascular catheters based on required axial, flexural, and torsional rigidities
    Jason Carey
    Department of Mechanical Engineering, University of Alberta, Edmonton, Alberta, Canada T6G 2G8
    J Biomed Mater Res B Appl Biomater 70:73-81. 2004
    ....
  83. ncbi Mechanical properties of organic nanofibers
    Jakob Kjelstrup-Hansen
    MIC Department of Micro and Nanotechnology, Technical University of Denmark, Building 345 east, 2800 Kgs Lyngby, Denmark
    Small 2:660-6. 2006
    ....
  84. ncbi Mechanical properties and grindability of dental cast Ti-Nb alloys
    Masafumi Kikuchi
    Division of Dental Biomaterials, Graduate School of Dentistry, Tohoku University 4 1, Seiryo machi, Aoba ku, Sendai, Miyagi, 980 8575 Japan
    Dent Mater J 22:328-42. 2003
    ..The Ti-30% Nb alloy exhibited significantly better grindability at low grinding speed with higher hardness, strength, and Young's modulus than titanium, presumably due to precipitation of the omega phase in the beta matrix...
  85. ncbi The contact mechanics of fractal surfaces
    Renato Buzio
    INFM Dipartimento di Fisica, Universita di Genova, Via Dodecaneso 33, 16146 Genova, Italy
    Nat Mater 2:233-6. 2003
    The role of surface roughness in contact mechanics is relevant to processes ranging from adhesion to friction, wear and lubrication...
  86. ncbi Mechanical properties and crystallization behaviors of nanostructured-Zno/PET in-situ composites
    Jie Tao
    College of Material Science and Technology, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, PR China
    J Nanosci Nanotechnol 6:3939-42. 2006
    ..2 wt% ZnO/PET composite could be a promising upgrade of PET due to the considerable improvement in mechanical properties...
  87. ncbi Piezoelectric thin films: evaluation of electrical and electromechanical characteristics for MEMS devices
    Klaus Prume
    aixACCT Systems GmbH, Aachen, Germany
    IEEE Trans Ultrason Ferroelectr Freq Control 54:8-14. 2007
    ..These data are essential for piezoelectric thin film process specification and the design and qualification of microelectromechanical systems devices...
  88. ncbi Morphology and mechanical stability of amyloid-like peptide fibrils
    Patrick Mesquida
    London Centre for Nanotechnology, Department of Medicine, University College London, 5 University Street, London, WC1E 6JJ, UK
    J Mater Sci Mater Med 18:1325-31. 2007
    ..Additional investigations by circular-dichroism spectroscopy showed that dispersed fibrils were structurally stable in aqueous solution between pH 3 and pH 8, and in sodium phosphate buffer of concentration between 50 mM and 1 M...
  89. ncbi Mechanical properties of glass-ceramic A-W-polyethylene composites: effect of filler content and particle size
    J A Juhasz
    Department of Materials Science and Metallurgy, University of Cambridge, Cambridge CB2 3QZ, UK
    Biomaterials 25:949-55. 2004
    ..A transition in fracture behaviour from ductile to brittle behaviour was observed in samples containing between 30 and 40 vol% filler...
  90. ncbi The mechanics of the middle-ear at static air pressures: the role of the ossicular joints, the function of the middle-ear muscles and the behaviour of stapedial prostheses
    K B Huttenbrink
    HNO Universitätsklinik Münster, West Germany
    Acta Otolaryngol Suppl 451:1-35. 1988
    ..This mode of motion has been the generally accepted concept of the ossicle-chain mechanics up to now...
  91. ncbi Aerosolized diuretics for preterm infants with (or developing) chronic lung disease
    L P Brion
    Albert Einstein College of Medicine, Children s Hospital at Montefiore, Pediatrics, Section of Neonatology, Weiler Hospital Room 725, 1825 Eastchester Road, Bronx, NY 10461 2373, USA
    Cochrane Database Syst Rev 3:CD001694. 2006
    ..Lung disease in preterm infants is often complicated with lung edema...
  92. ncbi Helium-hyperoxia, exercise, and respiratory mechanics in chronic obstructive pulmonary disease
    Neil D Eves
    Rehabilitation Medicine, University of Calgary, Calgary, AB, Canada T2N 1N4
    Am J Respir Crit Care Med 174:763-71. 2006
    ..Combining these gases could have an additive effect on dynamic hyperinflation and a greater impact on respiratory mechanics and exercise tolerance.
  93. ncbi The impact of morbid obesity, pneumoperitoneum, and posture on respiratory system mechanics and oxygenation during laparoscopy
    Juraj Sprung
    Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Anesth Analg 94:1345-50. 2002
    ..20 mm Hg pneumoperitoneum, and body posture (30 degrees head down and 30 degrees head up) on respiratory system mechanics, oxygenation, and ventilation during laparoscopy...
  94. doi Alteration of skin mechanics by thin polymer films
    Janusz Jachowicz
    Better Cosmetics LLC, Bethel, CT 06801 2912, USA
    Skin Res Technol 14:312-9. 2008
    ..The aim of the study was to assess whether high molecular weight synthetic polymers, in the form of simple skin treatment formulations, could modify mechanical properties of natural skin as well as artificial skin models...
  95. ncbi Partial liquid ventilation with and without inhaled nitric oxide in a newborn piglet model of meconium aspiration
    K J Barrington
    Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    Am J Respir Crit Care Med 160:1922-7. 1999
    ..effects of partial liquid ventilation (PLV) with and without inhaled nitric oxide (NO) over a 4-h period on lung mechanics, gas exchange, and hemodynamics in an animal model of meconium aspiration syndrome (MAS)...
  96. pmc Investigation of the mechanics of Type III stapes columella tympanoplasty using laser-Doppler vibrometry
    Wade Chien
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Otol Neurotol 28:782-7. 2007
    To investigate the middle ear mechanics of Type III stapes columella tympanoplasty using laser-Doppler vibrometry (LDV) and to determine whether LDV was useful in the identification of structural factors responsible for poor hearing ..
  97. doi Investigation of the mechanism of the cell wall DD-carboxypeptidase reaction of penicillin-binding protein 5 of Escherichia coli by quantum mechanics/molecular mechanics calculations
    Qicun Shi
    Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, USA
    J Am Chem Soc 130:9293-303. 2008
    ..This absence is addressed here by the use of explicit-solvent molecular dynamics simulations and ONIOM quantum mechanics/molecular mechanics (QM/MM) calculations...
  98. pmc The effect of postoperative passive motion on rotator cuff healing in a rat model
    Cathryn D Peltz
    McKay Orthopaedic Research Laboratory, University of Pennsylvania, 424 Stemmler Hall, 36th and Hamilton Walk, Philadelphia, PA 19104, USA
    J Bone Joint Surg Am 91:2421-9. 2009
    ..properties in an animal model of rotator cuff repair, and passive motion has been shown to improve joint mechanics in animal models of flexor tendon repair...
  99. ncbi A randomized trial of moderately early low-dose dexamethasone therapy in very low birth weight infants: dynamic pulmonary mechanics, oxygenation, and ventilation
    Manuel Durand
    Division of Neonatal Perinatal Medicine, Department of Pediatrics, Los Angeles County University of Southern California Medical Center, Los Angeles, California 90033, USA
    Pediatrics 109:262-8. 2002
    ..Quantification of dynamic pulmonary mechanics in VLBW infants who receive low-dose dexamethasone has not been reported...
  100. ncbi Lung mechanics and high-resolution computed tomography of the chest in very low birth weight premature infants
    Rosane Reis de Mello
    Departamento de Neonatologia, Instituto Fernandes Figueira, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil
    Sao Paulo Med J 121:167-72. 2003
    Premature infant lung development may be affected by lung injuries during the first few weeks of life. Lung injuries have been associated with changes in lung mechanics.
  101. ncbi [The changes of respiratory mechanics in patients with obstructive sleep apnea-hypopnea syndrome during sleep]
    Huan Ye
    Institute of Respiratory Medicine, Beijing Chaoyang Hospital Affiliated to the Capital University of Medical Sciences, Beijing 100020, China
    Zhonghua Jie He He Hu Xi Za Zhi 31:26-31. 2008
    To study the changes of respiratory mechanics in patients with obstructive sleep apnea hypopnea syndrome (OSAHS) during sleep.

Research Grants82

  1. Biomedical Simulations Resource (BMSR)
    DAVID Z D apos ARGENIO; Fiscal Year: 2010
    ..A major aspect of our work is to base all designs on physically rigorous molecular mechanics potentials with a continuum treatment of solvation...
  2. Biomedical Simulations Resource (BMSR)
    DAVID D ARGENIO; Fiscal Year: 2009
    ..A major aspect of our work is to base all designs on physically rigorous molecular mechanics potentials with a continuum treatment of solvation...
  3. Observing Auditory Mechanics with Pressure and Motion
    Elizabeth Olson; Fiscal Year: 2003
    The proposed project explores the mechanics of the cochlea and middle ear via measurements of sound pressure in the cochlea, the ear canal and the middle ear cavity...
  4. Ty3 viruslike particle morphogenesis and host interactions
    Suzanne Sandmeyer; Fiscal Year: 2010
    ..biochemical, and even cytological approaches, it provides a useful model for understanding retrotransposon mechanics. In the current funding period, the assembling Ty3 VLP was characterized by density sedimentation, RNA ..
  5. Mechanisms of Therapeutic Action in SCI
    Mehdi M Mirbagheri; Fiscal Year: 2010
    ..We hypothesize that tizanidine and the LOKOMAT will each modify reflex function and muscle mechanics;however, combining these techniques will improve outcomes over each intervention separately...
  6. Mechanisms of Therapeutic Action in SCI
    MEHDI MIRBAGHERI; Fiscal Year: 2009
    ..We hypothesize that tizanidine and the LOKOMAT will each modify reflex function and muscle mechanics;however, combining these techniques will improve outcomes over each intervention separately...
  7. OBSERVING AUDITORY MECHANICS WITH PRESSURE MEASUREMENTS
    Elizabeth Olson; Fiscal Year: 2001
    The proposed project explores the mechanics of the cochlea and middle ear via measurements of sound pressure in the cochlea, the ear canal and the middle ear cavity...
  8. OBSERVING AUDITORY MECHANICS WITH PRESSURE MEASUREMENTS
    Elizabeth Olson; Fiscal Year: 2001
    The proposed project explores the mechanics of the cochlea and middle ear via measurements of sound pressure in the cochlea, the ear canal and the middle ear cavity...
  9. OBSERVING AUDITORY MECHANICS WITH PRESSURE MEASUREMENTS
    Elizabeth Olson; Fiscal Year: 2005
    The proposed project explores the mechanics of the cochlea and middle ear via measurements of sound pressure in the cochlea, the ear canal and the middle ear cavity...
  10. OBSERVING AUDITORY MECHANICS WITH PRESSURE MEASUREMENTS
    Elizabeth Olson; Fiscal Year: 2002
    The proposed project explores the mechanics of the cochlea and middle ear via measurements of sound pressure in the cochlea, the ear canal and the middle ear cavity...
  11. OBSERVING AUDITORY MECHANICS WITH PRESSURE MEASUREMENTS
    Elizabeth Olson; Fiscal Year: 2004
    The proposed project explores the mechanics of the cochlea and middle ear via measurements of sound pressure in the cochlea, the ear canal and the middle ear cavity...
  12. OBSERVING AUDITORY MECHANICS WITH PRESSURE MEASUREMENTS
    Elizabeth Olson; Fiscal Year: 2003
    The proposed project explores the mechanics of the cochlea and middle ear via measurements of sound pressure in the cochlea, the ear canal and the middle ear cavity...
  13. Effect of Prosthetic Foot-Ankle Stiffness on Amputee Function
    GLENN KLUTE; Fiscal Year: 2011
    ..Clinicians are well aware that foot stiffness strongly influences the mechanics of amputee gait and prescribe ESAR feet with manufacturer-identified stiffness levels based on body weight and ..
  14. MUSCULOSKELETAL STIFFNESS AND LOCOMOTION
    CLAIRE FARLEY; Fiscal Year: 2000
    ..Experimental findings on the mechanics of running gaits have revealed that the overall musculoskeletal system behaves like a single linear spring in ..
  15. Image-based modeling of nonlinear and anisotropic intervertebral disc mechanics
    Edward J Vresilovic; Fiscal Year: 2010
    ..For over three decades finite element models have proved valuable to study disc mechanics. However, the currently available disc models have three significant limitations that will be addressed in this ..
  16. Image-based modeling of nonlinear and anisotropic intervertebral disc mechanics
    Dawn Elliott; Fiscal Year: 2009
    ..For over three decades finite element models have proved valuable to study disc mechanics. However, the currently available disc models have three significant limitations that will be addressed in this ..
  17. MUSCULOSKELETAL STIFFNESS AND LOCOMOTION
    CLAIRE FARLEY; Fiscal Year: 1999
    ..Experimental findings on the mechanics of running gaits have revealed that the overall musculoskeletal system behaves like a single linear spring in ..
  18. MUSCULOSKELETAL STIFFNESS AND LOCOMOTION
    CLAIRE FARLEY; Fiscal Year: 2000
    ..Experimental findings on the mechanics of running gaits have revealed that the overall musculoskeletal system behaves like a single linear spring in ..
  19. Bioengineering Studies of Abdominal Aortic Aneurysm Fluid and Wall Dynamics
    ENDER FINOL; Fiscal Year: 2009
    ..potential is the non-uniform arterial wall thickness, within the context of a dynamic assessment of aneurysm mechanics. Our overall goal is to address this hypothesis by predicting AAA risk of rupture on a patient-specific basis ..
  20. INTRACELLULAR CALCIUM IN HAIR CELLS
    Robert Fettiplace; Fiscal Year: 2010
    ..Experiments will focus on transducer channel adaptation and hair bundle mechanics to define their regulation by Ca2+ and roles in frequency selectivity...
  21. INTRACELLULAR CALCIUM IN HAIR CELLS
    Robert Fettiplace; Fiscal Year: 2009
    ..Experiments will focus on transducer channel adaptation and hair bundle mechanics to define their regulation by Ca2+ and roles in frequency selectivity...
  22. INTRACELLULAR CALCIUM IN HAIR CELLS
    Robert Fettiplace; Fiscal Year: 2009
    ..Experiments will focus on transducer channel adaptation and hair bundle mechanics to define their regulation by Ca2+ and roles in frequency selectivity...
  23. Biophysics of development buffering: Temperature as a tool to study how the cytos
    Lance A Davidson; Fiscal Year: 2010
    ..2003). The mechanics of embryo is likely to be a readout of the expression, localization and activity of a very large network of ..
  24. Engineering Developmental Microenvironments: Cartilage Formation and Maturation
    ROBERT LEON MAUCK; Fiscal Year: 2010
    ..Yet, the mechanics and ECM organization of engineered constructs for implantation have yet to match those of the native tissue and ..
  25. Engineering Developmental Microenvironments: Cartilage Formation and Maturation
    ROBERT LEON MAUCK; Fiscal Year: 2010
    ..Yet, the mechanics and ECM organization of engineered constructs for implantation have yet to match those of the native tissue and ..
  26. Engineering Developmental Microenvironments: Cartilage Formation and Maturation
    JASON BURDICK; Fiscal Year: 2009
    ..Yet, the mechanics and ECM organization of engineered constructs for implantation have yet to match those of the native tissue and ..
  27. REGIONAL MECHANICS OF LEFT VENTRICULAR ANEURYSM
    Julius Guccione; Fiscal Year: 1999
    ..these passive material properties will be used in an existing state-of-the-art finite element model for the mechanics of the beating ventricles to compute three-dimensional myocardial stress and deformation throughout the ..
  28. IN VITRO INVESTIGATION OF SLIDING MECHANICS
    Robert Kusy; Fiscal Year: 2001
    ..During treatment these patients will likely require some space closure or regaining via sliding mechanics. Unfortunately the uncertainty of frictional forces complicates the practitioner's best efforts to move teeth...
  29. IN VITRO INVESTIGATION OF SLIDING MECHANICS
    Robert Kusy; Fiscal Year: 2002
    ..During treatment these patients will likely require some space closure or regaining via sliding mechanics. Unfortunately the uncertainty of frictional forces complicates the practitioner's best efforts to move teeth...
  30. IN VITRO INVESTIGATION OF SLIDING MECHANICS
    Robert Kusy; Fiscal Year: 2000
    ..During treatment these patients will likely require some space closure or regaining via sliding mechanics. Unfortunately the uncertainty of frictional forces complicates the practitioner's best efforts to move teeth...
  31. FALL BIOMECHANICS AND HIP FRACTURE RISK
    Wilson Hayes; Fiscal Year: 1991
    ..These findings suggest that in addition to the increased incidence of falling, the mechanics of the fall itself may well dominate the occurrence of hip fracture in the elderly...
  32. Integrating and Evaluating the Modeling Applied to Problem Solving Pedagogy
    David Pritchard; Fiscal Year: 2009
    ..The MAPS pedagogy was initially deployed and further developed in a very successful three-week mechanics review course taught in January 2009...
  33. CARTILAGE MECHANICS IN SMALL ANIMAL MODELS OF OA
    Lori Setton; Fiscal Year: 1999
    ..Presently, there is no information on cartilage mechanics in small animal models (e.g...
  34. CARTILAGE MECHANICS IN SMALL ANIMAL MODELS OF OA
    Lori Setton; Fiscal Year: 2000
    ..Presently, there is no information on cartilage mechanics in small animal models (e.g...
  35. CARTILAGE MECHANICS IN SMALL ANIMAL MODELS OF OA
    Lori Setton; Fiscal Year: 2001
    ..Presently, there is no information on cartilage mechanics in small animal models (e.g...
  36. THORACOABDOMINAL ASYNCHRONY IN INFANT AIRWAY OBSTRUCTION
    Julian Allen; Fiscal Year: 1990
    ..It results in multiple abnormalities of lung mechanics, e.g., decreased lung compliance and increased airway resistance and work of breathing...
  37. THORACOABDOMINAL ASYNCHRONY IN INFANT AIRWAY OBSTRUCTION
    Julian Allen; Fiscal Year: 1991
    ..It results in multiple abnormalities of lung mechanics, e.g., decreased lung compliance and increased airway resistance and work of breathing...
  38. Mechanisms of Joint Damage Following Tendon Injury
    Louis J Soslowsky; Fiscal Year: 2010
    ..Tendon injuries through overuse, overload and/or tears are common conditions which can dramatically alter joint mechanics in a complex and multifactorial manner leading to significant joint damage...
  39. Respiratory Mechanics in Lung Disease and Surgery
    Stephen Loring; Fiscal Year: 2001
    ..We will continue an observational study of respiratory mechanics in a large cohort of patients with COPD before and after lung transplantation and LVRS...
  40. Respiratory Mechanics in Lung Disease and Surgery
    Stephen Loring; Fiscal Year: 2004
    ..We will continue an observational study of respiratory mechanics in a large cohort of patients with COPD before and after lung transplantation and LVRS...
  41. Respiratory Mechanics in Lung Disease and Surgery
    Stephen Loring; Fiscal Year: 2002
    ..We will continue an observational study of respiratory mechanics in a large cohort of patients with COPD before and after lung transplantation and LVRS...
  42. Respiratory Mechanics in Lung Disease and Surgery
    Stephen Loring; Fiscal Year: 2003
    ..We will continue an observational study of respiratory mechanics in a large cohort of patients with COPD before and after lung transplantation and LVRS...
  43. Carpal Kinematics During Functional Tasks
    Joseph Crisco; Fiscal Year: 2007
    ..This proposal focuses on the skeletal mechanics of the wrist and distal forearm during functional tasks...
  44. Carpal Kinematics During Functional Tasks
    Joseph Crisco; Fiscal Year: 2006
    ..This proposal focuses on the skeletal mechanics of the wrist and distal forearm during functional tasks...
  45. ANISOTROPHY AND NONLINEARITY OF CARTILAGE MECHANICS
    Gerard Ateshian; Fiscal Year: 2000
    ..several decades of sophisticated biomechanical studies of cartilage, an accurate understanding of cartilage mechanics remains elusive due to its remarkable versatility and complexity...
  46. ANISOTROPHY AND NONLINEARITY OF CARTILAGE MECHANICS
    Gerard Ateshian; Fiscal Year: 2001
    ..several decades of sophisticated biomechanical studies of cartilage, an accurate understanding of cartilage mechanics remains elusive due to its remarkable versatility and complexity...
  47. ANISOTROPHY AND NONLINEARITY OF CARTILAGE MECHANICS
    Gerard Ateshian; Fiscal Year: 2002
    ..several decades of sophisticated biomechanical studies of cartilage, an accurate understanding of cartilage mechanics remains elusive due to its remarkable versatility and complexity...
  48. ANISOTROPHY AND NONLINEARITY OF CARTILAGE MECHANICS
    Gerard Ateshian; Fiscal Year: 2003
    ..several decades of sophisticated biomechanical studies of cartilage, an accurate understanding of cartilage mechanics remains elusive due to its remarkable versatility and complexity...
  49. Predicting cell deformation from body level mechanical loads
    Ahmet Erdemir; Fiscal Year: 2010
    ..mechanisms can be studied in an isolated fashion but connecting mechanical cellular response to organ level mechanics and human movement requires a multiscale approach...
  50. Predicting cell deformation from body level mechanical loads
    Ahmet Erdemir; Fiscal Year: 2009
    ..mechanisms can be studied in an isolated fashion but connecting mechanical cellular response to organ level mechanics and human movement requires a multiscale approach...
  51. The biomechanics of morphogenesis in the frog
    Lance A Davidson; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The goal of this proposal is to apply a multi-scale analysis of the mechanics of convergent extension, identifying biomechanical mechanisms that regulate cell shape and drive mediolateral cell ..
  52. Histo-Mechanics & Biology of Remodeling in Hypertension
    JAY HUMPHREY; Fiscal Year: 2002
    ..Recent advances in vascular biology and mechanics suggest a paradigm shift in hypertension research...
  53. Histo-Mechanics & Biology of Remodeling in Hypertension
    JAY HUMPHREY; Fiscal Year: 2003
    ..Recent advances in vascular biology and mechanics suggest a paradigm shift in hypertension research...
  54. Histo-Mechanics & Biology of Remodeling in Hypertension
    JAY HUMPHREY; Fiscal Year: 2004
    ..Recent advances in vascular biology and mechanics suggest a paradigm shift in hypertension research...
  55. Histo-Mechanics & Biology of Remodeling in Hypertension
    JAY HUMPHREY; Fiscal Year: 2005
    ..Recent advances in vascular biology and mechanics suggest a paradigm shift in hypertension research...
  56. Histo-Mechanics & Biology of Remodeling in Hypertension
    JAY HUMPHREY; Fiscal Year: 2001
    ..Recent advances in vascular biology and mechanics suggest a paradigm shift in hypertension research...
  57. Biomechanical Characterization of Vocal Fold Tissues
    Roger Chan; Fiscal Year: 2009
    ..quantify the key biomechanical characteristics of human laryngeal tissues, so as to better understand the tissue mechanics of voice production, the potential mechanical factors responsible for voice disorders related to vocal overuse ..
  58. Biomechanical Characterization of Vocal Fold Tissues
    Roger Chan; Fiscal Year: 2009
    ..quantify the key biomechanical characteristics of human laryngeal tissues, so as to better understand the tissue mechanics of voice production, the potential mechanical factors responsible for voice disorders related to vocal overuse ..
  59. Exploring otoacoustic emissions with intracochlear pressure measurements
    Wei Dong; Fiscal Year: 2007
    ..the important issue of how sound energy travels out of the cochlea and to provide a bridge between cochlear mechanics and otoacoustic emissions...
  60. Anterior Cruciate Ligament Reconstruction and the Initiation of Osteoarthritis
    Thomas P Andriacchi; Fiscal Year: 2011
    ..by conducting a prospective study to fill critical gaps in the available knowledge on the nature of walking mechanics changes, graft function and cartilage thinning following ACL reconstruction...
  61. STRUCTURE AND MECHANISMS OF FAMILY 18 CHITINASES
    JEFFRY MADURA; Fiscal Year: 2002
    ..For example molecular mechanics/dynamics will be used to investigate the binding of polysaccharides to Chitinase A while coupled quantum ..
  62. STRUCTURE AND MECHANISMS OF FAMILY 18 CHITINASES
    JEFFRY MADURA; Fiscal Year: 1999
    ..For example molecular mechanics/dynamics will be used to investigate the binding of polysaccharides to Chitinase A while coupled quantum ..
  63. Ventilation Improves Lung Physiology and Biology
    Bela Suki; Fiscal Year: 2005
    ..tidal volume (Vt) and frequency on a cycle by cycle basis, called variable ventilation(VV), improves both lung mechanics and oxygenation in a rodent model of acute lung injury...
  64. Ventilation Improves Lung Physiology and Biology
    Bela Suki; Fiscal Year: 2006
    ..tidal volume (Vt) and frequency on a cycle by cycle basis, called variable ventilation(VV), improves both lung mechanics and oxygenation in a rodent model of acute lung injury...
  65. STRUCTURE AND MECHANISMS OF FAMILY 18 CHITINASES
    JEFFRY MADURA; Fiscal Year: 2001
    ..For example molecular mechanics/dynamics will be used to investigate the binding of polysaccharides to Chitinase A while coupled quantum ..
  66. STRUCTURE AND MECHANISMS OF FAMILY 18 CHITINASES
    JEFFRY MADURA; Fiscal Year: 2000
    ..For example molecular mechanics/dynamics will be used to investigate the binding of polysaccharides to Chitinase A while coupled quantum ..
  67. Ventilation Improves Lung Physiology and Biology
    Bela Suki; Fiscal Year: 2004
    ..tidal volume (Vt) and frequency on a cycle by cycle basis, called variable ventilation(VV), improves both lung mechanics and oxygenation in a rodent model of acute lung injury...
  68. Anterior Cruciate Ligament Reconstruction and the Initiation of Osteoarthritis
    Thomas Andriacchi; Fiscal Year: 2009
    ..by conducting a prospective study to fill critical gaps in the available knowledge on the nature of walking mechanics changes, graft function and cartilage thinning following ACL reconstruction...
  69. Anterior Cruciate Ligament Reconstruction and the Initiation of Osteoarthritis
    Thomas P Andriacchi; Fiscal Year: 2010
    ..by conducting a prospective study to fill critical gaps in the available knowledge on the nature of walking mechanics changes, graft function and cartilage thinning following ACL reconstruction...
  70. DIASTOLIC MECHANICS OF THE LEFT VENTRICLE AND LEFT ATRIU
    SERJAN NIKOLIC; Fiscal Year: 1992
    ..and Doppler velocity measurements, are capable of providing new and important information regarding the mechanics of diastole and the dynamics of filling...
  71. Evaluation of Canine Retraction Strategies
    Jie Chen; Fiscal Year: 2010
    ..in a similar way, thus playing an insignificant role in comparison to the differences in the two treatment mechanics. The specific aims (SA) are: SA-1 Characterize and quantify the mechanics of the treatment strategies using our ..
  72. Evaluation of Canine Retraction Strategies
    Jie Chen; Fiscal Year: 2009
    ..in a similar way, thus playing an insignificant role in comparison to the differences in the two treatment mechanics. The specific aims (SA) are: SA-1 Characterize and quantify the mechanics of the treatment strategies using our ..
  73. Observing auditory mechanics with pressure and motion measurements
    Elizabeth Olson; Fiscal Year: 2007
    ..provided by applicant): The primary objective of this research is to further our understanding of the mechanics of the healthy cochlea...
  74. Observing auditory mechanics with pressure and motion measurements
    Elizabeth Olson; Fiscal Year: 2006
    ..provided by applicant): The primary objective of this research is to further our understanding of the mechanics of the healthy cochlea...
  75. Mechanical Regulation of Binding and Cleavage of VWF by ADAMTS-13
    Cheng Zhu; Fiscal Year: 2009
    ..The objective is to elucidate how mechanics regulate these molecular processes in order to understand how their functions are regulated by the blood flow in ..
  76. Mechanical Regulation of Binding and Cleavage of VWF by ADAMTS-13
    Cheng Zhu; Fiscal Year: 2010
    ..The objective is to elucidate how mechanics regulate these molecular processes in order to understand how their functions are regulated by the blood flow in ..
  77. 3-D FLOW FIELDS IN CARDIOVASCULAR FLUID MECHANICS
    Ajit Yoganathan; Fiscal Year: 1992
    The faculty of the Cardiovascular Fluid Mechanics Laboratory at the Georgia Institute of Technology propose the acquisition of new research equipment to allow for state-of-the-art velocity measurement visualization in cardiovascular flow ..