electric conductivity


Summary: The ability of a substrate to allow the passage of ELECTRONS.

Top Publications

  1. ncbi Structural basis for modulation and agonist specificity of HCN pacemaker channels
    William N Zagotta
    Department of Physiology and Biophysics, Howard Hughes Medical Institute, Box 357290, University of Washington School of Medicine, Seattle, Washington 98195 7290, USA
    Nature 425:200-5. 2003
  2. ncbi Reconstruction of conductivity and current density images using only one component of magnetic field measurements
    Jin Keun Seo
    Department of Mathematics, Yonsei University, Seoul 120 749, Korea
    IEEE Trans Biomed Eng 50:1121-4. 2003
  3. pmc Principles of conduction and hydrophobic gating in K+ channels
    Morten Ø Jensen
    DE Shaw Research, New York, NY 10036, USA
    Proc Natl Acad Sci U S A 107:5833-8. 2010
  4. ncbi TRP-PLIK, a bifunctional protein with kinase and ion channel activities
    L W Runnels
    Howard Hughes Medical Institute, Department of Cardiology, Department of Neurobiology, Harvard Medical School, 1309 Enders Building, 320 Longwood Avenue, Children s Hospital, Boston, MA 02115, USA
    Science 291:1043-7. 2001
  5. ncbi mSlo, a complex mouse gene encoding "maxi" calcium-activated potassium channels
    A Butler
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110
    Science 261:221-4. 1993
  6. ncbi Balanced inhibition underlies tuning and sharpens spike timing in auditory cortex
    Michael Wehr
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nature 426:442-6. 2003
  7. ncbi Prestin is the motor protein of cochlear outer hair cells
    J Zheng
    The Hugh Knowles Center, Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    Nature 405:149-55. 2000
  8. ncbi Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain
    B Santoro
    Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
    Cell 93:717-29. 1998
  9. pmc Nanowired three-dimensional cardiac patches
    Tal Dvir
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nat Nanotechnol 6:720-5. 2011
  10. ncbi Quantitative conductivity and permittivity imaging of the human brain using electric properties tomography
    Tobias Voigt
    Department of Electrical Engineering and Information Technology, Institute of Biomedical Engineering, Karlsruhe Institute of Technology, Karlsruhe, Germany
    Magn Reson Med 66:456-66. 2011

Detail Information

Publications393 found, 100 shown here

  1. ncbi Structural basis for modulation and agonist specificity of HCN pacemaker channels
    William N Zagotta
    Department of Physiology and Biophysics, Howard Hughes Medical Institute, Box 357290, University of Washington School of Medicine, Seattle, Washington 98195 7290, USA
    Nature 425:200-5. 2003
    ..On the basis of amino acid sequence similarity to HCN channels, the cyclic nucleotide-gated, and eag- and KAT1-related families of channels are probably related to HCN channels in structure and mechanism...
  2. ncbi Reconstruction of conductivity and current density images using only one component of magnetic field measurements
    Jin Keun Seo
    Department of Mathematics, Yonsei University, Seoul 120 749, Korea
    IEEE Trans Biomed Eng 50:1121-4. 2003
    ..In our new MRCDI technique, we need to measure only one component of the induced magnetic flux density and reconstruct both cross-sectional conductivity and current density images without any subject rotation...
  3. pmc Principles of conduction and hydrophobic gating in K+ channels
    Morten Ø Jensen
    DE Shaw Research, New York, NY 10036, USA
    Proc Natl Acad Sci U S A 107:5833-8. 2010
  4. ncbi TRP-PLIK, a bifunctional protein with kinase and ion channel activities
    L W Runnels
    Howard Hughes Medical Institute, Department of Cardiology, Department of Neurobiology, Harvard Medical School, 1309 Enders Building, 320 Longwood Avenue, Children s Hospital, Boston, MA 02115, USA
    Science 291:1043-7. 2001
    ..Inactivation of the kinase activity by site-directed mutagenesis and the channel's dependence on intracellular adenosine triphosphate (ATP) demonstrated that the channel's kinase activity is essential for channel function...
  5. ncbi mSlo, a complex mouse gene encoding "maxi" calcium-activated potassium channels
    A Butler
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110
    Science 261:221-4. 1993
    ..A large number of variant mSlo cDNAs were isolated, indicating that several diverse mammalian BK channel types are produced by a single gene...
  6. ncbi Balanced inhibition underlies tuning and sharpens spike timing in auditory cortex
    Michael Wehr
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nature 426:442-6. 2003
    ..Balanced inhibition might thus serve to increase the temporal precision and thereby reduce the randomness of cortical operation, rather than to increase noise as has been proposed previously...
  7. ncbi Prestin is the motor protein of cochlear outer hair cells
    J Zheng
    The Hugh Knowles Center, Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    Nature 405:149-55. 2000
    ..We also demonstrate this nonlinear capacitance in transfected kidney cells. We conclude that prestin is the motor protein of the cochlear outer hair cell...
  8. ncbi Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain
    B Santoro
    Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
    Cell 93:717-29. 1998
  9. pmc Nanowired three-dimensional cardiac patches
    Tal Dvir
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nat Nanotechnol 6:720-5. 2011
    ..It is expected that the integration of conducting nanowires within three-dimensional scaffolds may improve the therapeutic value of current cardiac patches...
  10. ncbi Quantitative conductivity and permittivity imaging of the human brain using electric properties tomography
    Tobias Voigt
    Department of Electrical Engineering and Information Technology, Institute of Biomedical Engineering, Karlsruhe Institute of Technology, Karlsruhe, Germany
    Magn Reson Med 66:456-66. 2011
    ..g., in tumor diagnosis. In the framework of radiofrequency safety, the electric conductivity of tissue is needed to correctly estimate the local specific absorption rate distribution during MR ..
  11. ncbi Synthesis of oxidation-resistant cupronickel nanowires for transparent conducting nanowire networks
    Aaron R Rathmell
    Department of Chemistry, Duke University, 124 Science Drive, Box 90354 Durham, North Carolina 27708, United States
    Nano Lett 12:3193-9. 2012
    ..These properties, and the fact that copper and nickel are 1000 times more abundant than indium or silver, make cupronickel nanowires a promising alternative for the sustainable, efficient production of transparent conductors...
  12. ncbi Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering
    Laleh Ghasemi-Mobarakeh
    Islamic Azad University, Najafabad Branch, Isfahan, Iran
    J Tissue Eng Regen Med 5:e17-35. 2011
    ..Different procedures of electrical stimulation which have been used in tissue engineering, with examples on their specific applications in tissue engineering, are also discussed...
  13. ncbi The effect of brain hematoma location on volumetric inductive phase shift spectroscopy of the brain with circular and magnetron sensor coils: a numerical simulation study
    R Rojas
    Universidad del Ejército y FAM EMGS Laboratorio Multidisciplinario de Investigación, DF, Mexico
    Physiol Meas 29:S255-66. 2008
    ..Furthermore it was found that the relative sensitivity of circular and magnetron sensor coils with respect to the occurrence of hematoma varies with the location of the hematoma...
  14. pmc Can high-field MREIT be used to directly detect neural activity? Theoretical considerations
    R J Sadleir
    J Crayton Pruitt Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611 6131, USA
    Neuroimage 52:205-16. 2010
    ..We also propose the idea of using MREIT as an alternative means of studying neuromodulation...
  15. ncbi Biophysical and molecular mechanisms of Shaker potassium channel inactivation
    T Hoshi
    Department of Molecular and Cellular Physiology, Stanford University, School of Medicine, CA 94305
    Science 250:533-8. 1990
    ..A region near the amino terminus with an important role in inactivation has now been identified. The results suggest a model where this region forms a cytoplasmic domain that interacts with the open channel to cause inactivation...
  16. pmc Cardiac anisotropy in boundary-element models for the electrocardiogram
    Mark Potse
    Research Center, Sacre Coeur Hospital, 5400 Boulevard Gouin Ouest, Montreal, QC, H4J 1C5, Canada
    Med Biol Eng Comput 47:719-29. 2009
    ..Its major disadvantage is its perceived inability to deal with the anisotropic electric conductivity of the myocardial interstitium, which led researchers to represent only intracellular anisotropy or ..
  17. ncbi Acute and chronic effects of smoking on inflammation markers in exhaled breath condensate in current smokers
    A Rembert Koczulla
    Department of Internal Medicine, Division of Pulmonary Diseases, University Hospital Giessen and Marburg, Marburg, Germany koczulla med uni marburg de
    Respiration 79:61-7. 2010
    ..Analysis of the exhaled breath condensate (EBC) can provide noninvasive markers that might be indicative of inflammation...
  18. ncbi Crystal structure of Escherichia coli MscS, a voltage-modulated and mechanosensitive channel
    Randal B Bass
    Division of Chemistry and Chemical Engineering, Biochemistry Option, Howard Hughes Medical Institute, Mail Code 114 96, California Institute of Technology, Pasadena, CA 91125, USA
    Science 298:1582-7. 2002
    ..Although MscS is likely to be structurally distinct from other ion channels, similarities in gating mechanisms suggest common structural elements...
  19. ncbi Current constrained voltage scaled reconstruction (CCVSR) algorithm for MR-EIT and its performance with different probing current patterns
    Ozlem Birgul
    Department of Electrical and Electronics Engineering, Middle East Technical University, 06531 Ankara, Turkey
    Phys Med Biol 48:653-71. 2003
    ..The spatial resolution is limited by the larger element size of the finite element mesh and twice the magnetic resonance image pixel size...
  20. ncbi The conductivity of the human skull: results of in vivo and in vitro measurements
    T F Oostendorp
    Department of Medical Physics and Biophysics, University of Nijmegen, The Netherlands
    IEEE Trans Biomed Eng 47:1487-92. 2000
    ..An explanation is provided for this discrepancy, indicating that the correct ratio is 1:1/15:1...
  21. ncbi Conductivity and current density image reconstruction using harmonic Bz algorithm in magnetic resonance electrical impedance tomography
    Suk Hoon Oh
    Graduate School of East West Medical Sciences, Kyung Hee University, Korea
    Phys Med Biol 48:3101-16. 2003
    ..The results suggest that in vitro and in vivo experimental studies with animal subjects are feasible. Further studies are requested to reduce the amount of injection current down to less than 1 mA for human subjects...
  22. ncbi Measurement of ion diffusion using magnetic resonance electrical impedance tomography
    Mark J Hamamura
    Tu and Yuen Center for Functional Onco Imaging, University of California, 164 Irvine Hall, Irvine, CA 92697 5020, USA
    Phys Med Biol 51:2753-62. 2006
    ..The results indicate that MREIT was able to monitor the changing conductivity and concentration distributions resulting from the diffusion of ions within the agarose gel phantom...
  23. ncbi Contactless conductivity detection for microfluidics: designs and applications
    Martin Pumera
    ICYS, National Institute for Materials Science, 1 1 Namiki, Tsukuba 305 0044, Japan
    Talanta 74:358-64. 2007
    ..Various applications for security, pharmacological, bioassays and food analysis purposes are described...
  24. ncbi Dipole location errors in electroencephalogram source analysis due to volume conductor model errors
    B Vanrumste
    Department of Electronics and Information Systems, Ghent University, Belgium
    Med Biol Eng Comput 38:528-34. 2000
    ..It was found that the location errors due to underestimating skull conductivity are typically higher than those found due to neglecting the VS or neglecting a hole in the skull...
  25. pmc Dielectrophoretic manipulation of cells with spiral electrodes
    X B Wang
    Department of Experimental Pathology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Biophys J 72:1887-99. 1997
    ..Applications of spiral electrode arrays, including the isolation of cells of clinical relevance, are discussed...
  26. ncbi Electrolyte-gated graphene field-effect transistors for detecting pH and protein adsorption
    Yasuhide Ohno
    The Institute of the Scientific and Industrial Research, Osaka University, Ibaraki, Osaka 567 0047, Japan
    Nano Lett 9:3318-22. 2009
    ..The GFETs thus acted as highly sensitive electrical sensors for detecting pH and biomolecule concentrations...
  27. ncbi Salt dependence of ion transport and DNA translocation through solid-state nanopores
    Ralph M M Smeets
    Kavli Institute of Nanoscience, Delft University of Technology, The Netherlands
    Nano Lett 6:89-95. 2006
    ..We demonstrate that the two competing effects cancel at a KCl concentration of 370 +/- 40 mM...
  28. ncbi The need for correct realistic geometry in the inverse EEG problem
    G Huiskamp
    Department of Clinical Neurophysiology, University Hospital Utrecht, The Netherlands
    IEEE Trans Biomed Eng 46:1281-7. 1999
    ..These errors are comparable to those found when overestimating or underestimating skull conductivity by a factor of two...
  29. ncbi Novel dry polymer foam electrodes for long-term EEG measurement
    Chin Teng Lin
    Department of Electrical Engineering, Institute of Imaging and Biomedical Photonics and Brain Research Center, National Chiao Tung University, Hsinchu 300, Taiwan
    IEEE Trans Biomed Eng 58:1200-7. 2011
    ..The experimental results presented that the dry foam electrode performs better for long-term EEG measurement, and is practicable for daily life applications...
  30. ncbi Electrical conductivity imaging using gradient B, decomposition algorithm in magnetic resonance electrical impedance tomography (MREIT)
    Chunjae Park
    College of Electronics and Information, Kyung Hee University, Kyungki 449 701, Korea
    IEEE Trans Med Imaging 23:388-94. 2004
    ..Numerical simulations with added random noise of realistic amounts show the feasibility of the algorithm in practical applications and also its robustness against measurement noise...
  31. pmc Two modes of polyamine block regulating the cardiac inward rectifier K+ current IK1 as revealed by a study of the Kir2.1 channel expressed in a human cell line
    Keiko Ishihara
    Department of Physiology, Saga Medical School, 5 1 1 Nabeshima, Saga 849 8501, Japan
    J Physiol 556:61-78. 2004
    ..Polyamines may regulate the amplitude of the outward I(K1), not only by blocking the channels but also by modifying the proportion of channels that show different sensitivities to the polyamine block...
  32. ncbi How spike generation mechanisms determine the neuronal response to fluctuating inputs
    Nicolas Fourcaud-Trocmé
    Centre National de la Recherche Scientifique Unité Mixte de Recherche 8119, Neurophysique et Physiologie du Système Moteur, Unité de Formation et de Recherche Biomédicale, Universite Paris 5 Rene Descartes, 75270 Paris Cedex 06, France
    J Neurosci 23:11628-40. 2003
    ..Our study shows how an intrinsic neuronal property (the characteristics of fast sodium channels) determines the speed with which neurons can track changes in input...
  33. ncbi A functional connection between the pores of distantly related ion channels as revealed by mutant K+ channels
    L Heginbotham
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115
    Science 258:1152-5. 1992
  34. ncbi Solution-processed metal nanowire mesh transparent electrodes
    Jung Yong Lee
    Department of Electrical Engineering, Stanford University, Stanford, California 94305, USA
    Nano Lett 8:689-92. 2008
    ..Organic solar cells deposited on these electrodes show a performance equivalent to that of devices based on a conventional metal-oxide transparent electrode...
  35. ncbi The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways
    A N Akopian
    Molecular Nociception Group, Department of Biology, Medawar Building, University College, London WC1E 6BT, UK
    Nat Neurosci 2:541-8. 1999
    ..These data show that SNS is involved in pain pathways and suggest that blockade of SNS expression or function may produce analgesia without side effects...
  36. pmc TRPC channel activation by extracellular thioredoxin
    Shang Zhong Xu
    Institute of Membrane and Systems Biology, Garstang Building, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK
    Nature 451:69-72. 2008
    ..The data indicate the presence of a previously unrecognized ion-channel activation mechanism that couples extracellular thioredoxin to cell function...
  37. ncbi A large-conductance mechanosensitive channel in E. coli encoded by mscL alone
    S I Sukharev
    Laboratory of Molecular Biology, University of Wisconsin Madison 53706
    Nature 368:265-8. 1994
    ..The mscL nucleotide sequence predicts a unique protein of only 136 amino acids, with a highly hydrophobic core and very different from porins or other known proteins...
  38. pmc Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant
    H Wulff
    Department of Physiology and Biophysics, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 97:8151-6. 2000
    ..Combinations of TRAM-34 and cyclosporin A are more effective in suppressing lymphocyte mitogenesis than either compound alone. Our studies suggest that TRAM-34 and related compounds may hold therapeutic promise as immunosuppressants...
  39. ncbi In vivo electrical conductivity of hepatic tumours
    Dieter Haemmerich
    Department of Surgery, University of Wisconsin Madison, 600 Highland Avenue, WI 53792, USA
    Physiol Meas 24:251-60. 2003
    ..05). We conclude that necrosis within the tumour and the associated membrane breakdown is likely responsible for the observed change in conductivity...
  40. ncbi Restoration of inactivation in mutants of Shaker potassium channels by a peptide derived from ShB
    W N Zagotta
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, CA 94305
    Science 250:568-71. 1990
    ..These results support the proposal that inactivation occurs by a cytoplasmic domain that occludes the ion-conducting pore of the channel...
  41. pmc From antiferromagnetic insulator to correlated metal in pressurized and doped LaMnPO
    J W Simonson
    Department of Physics and Astronomy, Stony Brook University, Stony Brook, NY 11794, USA
    Proc Natl Acad Sci U S A 109:E1815-9. 2012
    ..Proximity to these charge and moment delocalization transitions in LaMnPO results in a highly correlated metallic state, the familiar breeding ground of superconductivity...
  42. ncbi Capacitively coupled contactless conductivity detection for microseparation techniques - recent developments
    Pavel Kuban
    Institute of Analytical Chemistry of the Academy of Sciences of the Czech Republic, Brno, Czech Republic
    Electrophoresis 32:30-42. 2011
  43. pmc Determination of soil pore water salinity using an FDR sensor working at various frequencies up to 500 MHz
    Andrzej Wilczek
    Institute of Agrophysics, Polish Academy of Sciences, ul Doświadczalna 4, 20 290 Lublin, Poland
    Sensors (Basel) 12:10890-905. 2012
    ..As a result, the salinity index method applied for FDR measurements may be adapted to field use after examination of loam and clayey soils...
  44. ncbi Current saturation and voltage gain in bilayer graphene field effect transistors
    B N Szafranek
    Advanced Microelectronic Center Aachen AMICA, AMO GmbH, Otto Blumenthal Strasse 25, 52074 Aachen, Germany
    Nano Lett 12:1324-8. 2012
    ..Using numerical simulations based on an atomistic p(z) tight-binding Hamiltonian we demonstrate that this approach can be extended to sub-100 nm gate lengths...
  45. ncbi Magnetic induction tomography: hardware for multi-frequency measurements in biological tissues
    H Scharfetter
    Institute for Biomedical Engineering, Technical University of Graz, Austria
    Physiol Meas 22:131-46. 2001
    ..On-line spectroscopy of tissue conductivity with low spatial resolution appears feasible, thus enabling applications such as non-invasive monitoring of brain oedema...
  46. ncbi Flexible solid-state supercapacitors based on three-dimensional graphene hydrogel films
    Yuxi Xu
    Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, United States
    ACS Nano 7:4042-9. 2013
    ..6 μA), excellent cycling stability, and extraordinary mechanical flexibility. This study demonstrates the exciting potential of 3D graphene macrostructures for high-performance flexible energy storage devices...
  47. ncbi Conducting polymers in electronic chemical sensors
    Jiri Janata
    School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332 0400, USA
    Nat Mater 2:19-24. 2003
    ..Our aim here is to discuss the usability of conducting polymers in both types of electronic applications in light of these two parameters...
  48. ncbi Metal-intercalated aromatic hydrocarbons: a new class of carbon-based superconductors
    Yoshihiro Kubozono
    Research Laboratory for Surface Science, Okayama University, Okayama, Japan
    Phys Chem Chem Phys 13:16476-93. 2011
    ..The features of other carbon-based superconductors are compared to clarify the nature of hydrocarbon superconductors...
  49. ncbi Scanning tunneling microscopy characterization of the electrical properties of wrinkles in exfoliated graphene monolayers
    Ke Xu
    Division of Chemistry and Chemical Engineering, Kavli Nanoscience Institute, California Institute of Technology, MC 127 72, Pasadena, California 91125, USA
    Nano Lett 9:4446-51. 2009
    ..The observed wrinkles are likely important for understanding the electrical properties of graphene...
  50. ncbi Solution-processed metallic conducting polymer films as transparent electrode of optoelectronic devices
    Yijie Xia
    Department of Materials and Engineering, National University of Singapore, Singapore
    Adv Mater 24:2436-40. 2012
    ..These PEDOT:PSS films with conductivity and transparency comparable to ITO can replace ITO as the transparent electrode of optoelectronic devices...
  51. ncbi A comparison of conductive textile-based and silver/silver chloride gel electrodes in exercise electrocardiogram recordings
    Vaidotas Marozas
    Kaunas University of Technology, Biomedical Engineering Institute, Kaunas, Lithuania
    J Electrocardiol 44:189-94. 2011
    ..The goal of this study was to compare disposable silver/silver chloride and reusable conductive textile-based electrodes in electrocardiogram (ECG) signal monitoring during physical activity...
  52. ncbi Use of conductive gels for electric field homogenization increases the antitumor efficacy of electroporation therapies
    Antoni Ivorra
    Department of Bioengineering, Department of Mechanical Engineering and Graduate Programin Biophysics, University of California at Berkeley, Berkeley, CA 94720, USA
    Phys Med Biol 53:6605-18. 2008
    ..We found that conductivity mismatching errors are surprisingly well tolerated by the technique. Gels with conductivities ranging from 5 mS cm(-1) to 10 mS cm(-1) will be a proper solution for most cases...
  53. ncbi Determination of electric conductivity and local SAR via B1 mapping
    Ulrich Katscher
    Medical Imaging Systems Division, Philips Research Europe, Hamburg, Germany
    IEEE Trans Med Imaging 28:1365-74. 2009
    The electric conductivity can potentially be used as an additional diagnostic parameter, e.g., in tumor diagnosis...
  54. ncbi In vivo muscle electroporation threshold determination: realistic numerical models and in vivo experiments
    Selma Corovic
    University of Ljubljana, Trzaska 25, 1000 Ljubljana, Slovenia
    J Membr Biol 245:509-20. 2012
    ..Our model of muscle with skin also confirms the in vivo findings of previous studies that electroporation "breaks" the skin barrier when the applied voltage is above 50 V...
  55. ncbi Identifying single nucleotides by tunnelling current
    Makusu Tsutsui
    The Institute of Scientific and Industrial Research, Osaka University, 8 1 Mihogaoka, Ibaraki, Osaka 567 0047, Japan
    Nat Nanotechnol 5:286-90. 2010
    ..We also demonstrate statistical identification of the nucleotides based on their electrical conductivity, thereby providing an experimental basis for a DNA sequencing technology based on measurements of electron transport...
  56. pmc Novel anisotropic engineered cardiac tissues: studies of electrical propagation
    Nenad Bursac
    Biomedical Engineering Department, Duke University, 3000 Science Drive, Durham, NC 27708, USA
    Biochem Biophys Res Commun 361:847-53. 2007
    ..In summary, this study is the first successful attempt to engineer a cm(2)-size, functional anisotropic cardiac tissue patch...
  57. ncbi The stimulation of myoblast differentiation by electrically conductive sub-micron fibers
    Indong Jun
    Department of Bioengineering, Hanyang University, Seongdong Gu, Seoul, Republic of Korea
    Biomaterials 30:2038-47. 2009
  58. pmc NMDA receptor contributions to visual contrast coding
    Michael B Manookin
    Neuroscience Program, University of Michigan, Ann Arbor, MI 48105, USA
    Neuron 67:280-93. 2010
    ..NMDA receptors contribute to visual contrast coding in a cell-type-specific manner. Certain cell types generate excitatory responses using primarily AMPA receptors or disinhibition...
  59. pmc Tuning transport properties of nanofluidic devices with local charge inversion
    Yan He
    Department of Physics and Astronomy, University of California, Irvine, Irvine, California, USA
    J Am Chem Soc 131:5194-202. 2009
    ..These effects are reversible so that the transport and selectivity characteristics of ionic devices can be tuned, much as the gate voltage tunes the properties of a semiconductor...
  60. ncbi Measuring the dielectric properties of herpes simplex virus type 1 virions with dielectrophoresis
    Michael P Hughes
    Department of Electronics and Electrical Engineering, Bioelectronic Research Centre, University of Glasgow, Scotland, Glasgow, UK
    Biochim Biophys Acta 1571:1-8. 2002
    ..It is shown that the observed changes in the dielectrophoretic spectrum, and the variations in the dielectric properties of the virus concur with the expected physiological effects of these agents...
  61. pmc Role for calcium-activated potassium channels (BK) in growth control of human malignant glioma cells
    Amy K Weaver
    Department of Neurobiology, Civitan International Research Center, University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Neurosci Res 78:224-34. 2004
  62. pmc Heterotypic docking of Cx43 and Cx45 connexons blocks fast voltage gating of Cx43
    S Elenes
    Krannert Institute of Cardiology, Indiana University, Indianapolis, Indiana 46202, USA
    Biophys J 81:1406-18. 2001
    ..Our results also suggest that heterotypic docking may lead to conformational changes that inhibit this action of the Cx43 carboxyl-terminal domain...
  63. pmc Ceramide, a putative second messenger for nerve growth factor, modulates the TTX-resistant Na(+) current and delayed rectifier K(+) current in rat sensory neurons
    Y H Zhang
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    J Physiol 544:385-402. 2002
    ..This NGF-induced sensitization is probably mediated by activation of the sphingomyelin signalling pathway to liberate ceramide(s), wherein ceramide appears to be the second messenger involved in modulating neuronal excitability...
  64. ncbi Gap junctions remain open during cytochrome c-induced cell death: relationship of conductance to 'bystander' cell killing
    K Cusato
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Cell Death Differ 13:1707-14. 2006
  65. ncbi Influence of anisotropic conductivity on EEG source reconstruction: investigations in a rabbit model
    Daniel Güllmar
    Biomagnetic Center, Department of Neurology, Jena, Germany
    IEEE Trans Biomed Eng 53:1841-50. 2006
    ..In contrast, dipole orientation and dipole strength are influenced significantly by the anisotropy. We conclude that the inclusion of tissue anisotropy information improves source estimation procedures...
  66. pmc Large diameter of palytoxin-induced Na/K pump channels and modulation of palytoxin interaction by Na/K pump ligands
    Pablo Artigas
    Laboratory of Cardiac Membrane Physiology, Rockefeller University, New York, NY 10021 6399, USA
    J Gen Physiol 123:357-76. 2004
    ..5 A wide. Enhanced understanding of palytoxin action now allows its use for examining the structures and mechanisms of the gates that occlude/deocclude transported ions during the normal Na/K pump cycle...
  67. ncbi PIP(2) activates KCNQ channels, and its hydrolysis underlies receptor-mediated inhibition of M currents
    Hailin Zhang
    Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York University, New York, NY 10029, USA
    Neuron 37:963-75. 2003
    ..Finally, native or recombinant channels inhibited by muscarinic agonists can be activated by PIP(2). Our data strongly suggest that PIP(2) acts as a membrane-diffusible second messenger to regulate directly the activity of KCNQ currents...
  68. pmc Estimation of the pore size of the large-conductance mechanosensitive ion channel of Escherichia coli
    C C Cruickshank
    Department of Pharmacology, University of Western Australia, Nedlands
    Biophys J 73:1925-31. 1997
    ..This channel diameter is consistent with the proposed homohexameric model of the MscL...
  69. ncbi A chemical route to graphene for device applications
    Scott Gilje
    Department of Chemistry and Biochemistry and California NanoSystems Institute, University of California, Los Angeles, Los Angeles, California 90095, USA
    Nano Lett 7:3394-8. 2007
    ..Temperature-dependent conductivity indicates that the graphene-like sheets exhibit semiconducting behavior...
  70. ncbi Mechanism of C2-toxin inhibition by fluphenazine and related compounds: investigation of their binding kinetics to the C2II-channel using the current noise analysis
    Christoph Bachmeyer
    CNR ITC Istituto di Biofisica Sezione di Trento, Via Sommarive 18, I 38050, Povo, Italy
    J Mol Biol 333:527-40. 2003
    ..The off-rate varied between about 10 s(-1) and 3900 s(-1) and depended on the structure of the ligand. The role of structural requirements for the effective block of C2II by the different ligands is discussed...
  71. pmc A flexible strain sensor based on a Conductive Polymer Composite for in situ measurement of parachute canopy deformation
    Cédric Cochrane
    University Lille Nord de France, F 59000 Lille, France
    Sensors (Basel) 10:8291-303. 2010
    ..Finally, our sensor was tested on a parachute canopy during a real drop test: the canopy fabric deformation during the critical inflation phase was successfully measured, and was found to be less than 9%...
  72. ncbi Fundamental aspects of contactless conductivity detection for capillary electrophoresis. Part I: Frequency behavior and cell geometry
    Pavel Kuban
    Department of Chemistry, University of Basel, Basel, Switzerland
    Electrophoresis 25:3387-97. 2004
    ..The frequency setting has to be optimized for each cell design, operational amplifier, electrolyte solution and capillary...
  73. ncbi The aromatic binding site for tetraethylammonium ion on potassium channels
    L Heginbotham
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115
    Neuron 8:483-91. 1992
    ..These findings are consistent with a TEA-binding site formed by a bracelet of pore-lining aromatic residues. The center of the bracelet could bind a TEA molecule through a cation-pi orbital interaction...
  74. ncbi Electric currents couple spatially separated biogeochemical processes in marine sediment
    Lars Peter Nielsen
    Department of Biological Sciences, Aarhus University, Ny Munkegade 114, DK 8000 Aarhus C, Denmark
    Nature 463:1071-4. 2010
    ..Electrical communication between distant chemical and biological processes in nature adds a new dimension to our understanding of biogeochemistry and microbial ecology...
  75. ncbi Functionalized single graphene sheets derived from splitting graphite oxide
    Hannes C Schniepp
    J Phys Chem B 110:8535-9. 2006
    ..Although graphite oxide is an insulator, functionalized graphene produced by this method is electrically conducting...
  76. pmc Accordion-like honeycombs for tissue engineering of cardiac anisotropy
    George C Engelmayr
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, E25 330 Cambridge, Massachusetts 02139, USA
    Nat Mater 7:1003-10. 2008
  77. ncbi Pacemaker channels produce an instantaneous current
    Catherine Proenza
    Ion Channel Laboratory, School of Kinesiology, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada
    J Biol Chem 277:5101-9. 2002
  78. pmc Decreased agonist affinity and chloride conductance of mutant glycine receptors associated with human hereditary hyperekplexia
    D Langosch
    Max Planck Institut für Hirnforschung, Frankfurt, Germany
    EMBO J 13:4223-8. 1994
    ..In addition, our data reveal that structural modifications of the ion-channel region can affect agonist binding to the glycine receptor...
  79. ncbi Computer model of action potential of mouse ventricular myocytes
    Vladimir E Bondarenko
    Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York 14214 3078, USA
    Am J Physiol Heart Circ Physiol 287:H1378-403. 2004
    ..The attribution of putative molecular bases for several of the component currents enables our mouse model to be used to simulate the behavior of genetically modified transgenic mice...
  80. ncbi Artificial synaptic conductances reduce subthreshold oscillations and periodic firing in stellate cells of the entorhinal cortex
    Fernando R Fernandez
    Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02115, USA
    J Neurosci 28:3790-803. 2008
    ..Our results suggest that subthreshold oscillations may contribute less to in vivo response properties than has been hypothesized...
  81. ncbi IgG from patients with Lambert-Eaton syndrome blocks voltage-dependent calcium channels
    Y I Kim
    Department of Neurology, University of Virginia School of Medicine, Charlottesville 22908
    Science 239:405-8. 1988
    ..Therefore, Lambert-Eaton syndrome IgG reacts with voltage-dependent calcium channels and blocks their function, a phenomenon that can account for the presynaptic impairment characteristic of this disorder...
  82. pmc Magnetoacoustic tomography with magnetic induction (MAT-MI)
    Yuan Xu
    Department of Biomedical Engineering, University of Minnesota, 7 105 BSBE, 312 Church Street, Minneapolis, MN 55455, USA
    Phys Med Biol 50:5175-87. 2005
    ..The promising pilot experimental results suggest the feasibility of the proposed MAT-MI approach...
  83. ncbi Characterization of nucleic acids by nanopore analysis
    David W Deamer
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA
    Acc Chem Res 35:817-25. 2002
    ..As each molecule occupies the pore, a characteristic blockade of ionic current is produced. Information about length, composition, structure, and dynamic motion of the molecule can be deduced from modulations of the current blockade...
  84. pmc Characterization of basolateral K+ channels underlying anion secretion in the human airway cell line Calu-3
    Elizabeth A Cowley
    Department of Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4H7
    J Physiol 538:747-57. 2002
  85. pmc Gating of the large mechanosensitive channel in situ: estimation of the spatial scale of the transition from channel population responses
    Chien Sung Chiang
    Department of Biology, University of Maryland College Park, Maryland 20742, USA
    Biophys J 86:2846-61. 2004
    ..4 +/- 4.8 nm(2), the latter being consistent with structural models of MscL, which predict deltaA = 23 nm(2)...
  86. ncbi Crystal and molecular structure of human annexin V after refinement. Implications for structure, membrane binding and ion channel formation of the annexin family of proteins
    R Huber
    Max Planck Institut fur Biochemie, Martinsried, Germany
    J Mol Biol 223:683-704. 1992
    ..We suggest that annexins bind with their convex face to membranes, causing local disorder and permeability of the phospholipid bilayers. Annexins are Janus-faced proteins that face phospholipid and water and mediate calcium transport...
  87. ncbi Bcl-2-dependent modulation of Ca(2+) homeostasis and store-operated channels in prostate cancer cells
    Fabien Vanden Abeele
    Laboratoire de Physiologie Cellulaire, INSERM EPI 9938, Universite des Sciences et Technologies de Lille, Batiment SN3, 59655 Villeneuve d Ascq cedex, France
    Cancer Cell 1:169-79. 2002
    ..Our data therefore suggest the pivotal role of SOCs in apoptosis and cancer progression...
  88. ncbi The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7)
    A Surprenant
    Glaxo Institute for Molecular Biology, Geneva, Switzerland
    Science 272:735-8. 1996
    ..Thus, the P2X7 (or P2Z) receptor is a bifunctional molecule that could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells...
  89. ncbi A global sensitivity analysis of three- and four-layer EEG conductivity models
    Sylvain Vallaghé
    Odysśee Team Project, Institut National de Recherche en Informatique et en Automatique, Sophia Antipolis 06902, France
    IEEE Trans Biomed Eng 56:988-95. 2009
    ..This global sensitivity analysis gives new information about EEG forward models--it identifies the main input parameters that need model refinement--and directions on how to calibrate these models...
  90. ncbi Single molecule measurements of DNA transport through a nanopore
    Amit Meller
    The Rowland Institute for Science at Harvard, 100 Edwin H Land Boulkevard, Cambridge, MA 02142, USA
    Electrophoresis 23:2583-91. 2002
    ..The single molecule approach we used revealed molecular interactions that can influence both capture rates and translocation velocities in a manner that enriches naive barrier crossing models...
  91. ncbi Daily electrical silencing in the mammalian circadian clock
    Mino D C Belle
    Faculty of Life Sciences, A V Hill Building, University of Manchester, Manchester M13 9PT, UK
    Science 326:281-4. 2009
  92. ncbi Estimating brain conductivities and dipole source signals with EEG arrays
    David Gutierrez
    Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607 7053, USA
    IEEE Trans Biomed Eng 51:2113-22. 2004
    ..We also present numerical examples evaluating the sensitivity to imprecise assumptions on the source position and skull thickness. Finally, we propose extensions to the case of unknown source position and present examples for real data...
  93. ncbi The contribution of Shaker K+ channels to the information capacity of Drosophila photoreceptors
    Jeremy E Niven
    Physiological Laboratory, University of Cambridge, Cambridge CB2 3EG, UK
    Nature 421:630-4. 2003
  94. pmc The effect of polypyrrole on arteriogenesis in an acute rat infarct model
    Shirley S Mihardja
    Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143, USA
    Biomaterials 29:4205-10. 2008
    ..The results of this study highlight the potential clinical benefit of using this alginate-polypyrrole polymer blend as an injectable scaffold to repair ischemic myocardium after myocardial infarction...
  95. pmc Taurine suppresses the spread of cell death in electrically coupled RPE cells
    Chandani Udawatte
    Department of Ophthalmology and Visual Sciences, University of Illinois College of Medicine, Chicago, IL 60612, USA
    Mol Vis 14:1940-50. 2008
  96. ncbi Cell-cycle-dependent expression of the large Ca2+-activated K+ channels in breast cancer cells
    Halima Ouadid-Ahidouch
    Laboratoire de Physiologie Cellulaire, INSERM EMI 0228, SN3, Universite des Sciences et Technologies de Lille, 59655 Villeneuve d Ascq cedex, France
    Biochem Biophys Res Commun 316:244-51. 2004
    ..However, these K+ channels did not regulate the cell proliferation because of their minor role in the membrane potential...
  97. ncbi Cellular mechanisms of direct-current electric field effects: galvanotaxis and metastatic disease
    Maria E Mycielska
    Department of Biological Sciences, Neuroscience Solutions to Cancer Research Group, Imperial College London, Sir Alexander Fleming Building, South Kensington Campus, London, SW7 2AZ, UK
    J Cell Sci 117:1631-9. 2004
    ..This could have important implications for the metastatic process and has clinical implications. Galvanotaxis could thus play a significant role in both cellular physiology and pathophysiology...
  98. pmc Slow gating charge immobilization in the human potassium channel Kv1.5 and its prevention by 4-aminopyridine
    D Fedida
    Department of Physiology, Queen s University, Kingston, Ontario, Canada
    J Physiol 494:377-87. 1996
    ..Some actions of 4-AP appear independent of its properties as a blocker of open K+ channels, and are not mimicked by internal TEA...
  99. ncbi The size of gating charge in wild-type and mutant Shaker potassium channels
    N E Schoppa
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510
    Science 255:1712-5. 1992
    ..These results can be explained by a model for channel activation in which the equilibria of voltage-dependent steps are altered in the mutant channels...
  100. pmc Effects of membrane potential on the voltage dependence of motility-related charge in outer hair cells of the guinea-pig
    J Santos-Sacchi
    Sections of Otolaryngology and Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    J Physiol 510:225-35. 1998
    ..Through modelling, we indicate how the effect may be explained by an intrinsic voltage-induced tension generated by the molecular motors residing in the lateral membrane...
  101. ncbi Highly efficient restoration of graphitic structure in graphene oxide using alcohol vapors
    Ching Yuan Su
    Research Center for Applied Sciences, Academia Sinica, Taipei 11529, Taiwan
    ACS Nano 4:5285-92. 2010
    ..In the high mobility regime, the growth of the graphitic domain size becomes dominant for enhancing its electrical conductivity. The excellent electrical conductivity of the reduced GO sheets promises potential electronic applications...

Research Grants62

  1. Mechanism of G protein Activation by Ric-8A
    Stephen R Sprang; Fiscal Year: 2013
  2. Biosensing in electrochemically controlled nano-junctions
    Krzysztof Slowinski; Fiscal Year: 2013
    ..g. TATA binding protein) at the single molecule level. Demonstrating the feasibility of such detection is critically important in the development of DNA based nano-sensors. ..
  3. Multi-excitation magnetoacoustic imaging of tissue conductivities
    Bin He; Fiscal Year: 2013
    ..The successful development of a high-resolution, non-ionizing, cost-effective electrical impedance imaging system will have a significant impact to screening and early detection of breast cancer. ..
  4. Biophysical Modeling of Fluid and Solute Transport in the TMJ Disc
    Hai Yao; Fiscal Year: 2010
    ..In future studies we will use the pig to test these models further, compare different regenerative regimens, as well as design and evaluate human replacement TMJ tissues. ..
  5. LLISA: ???Liposome-Linked Immunosorbant Assay??? for Detection of HIV Viral Load
    Abraham P Lee; Fiscal Year: 2013
    ..With the integration of these two sets of expertise, we expect to address the grand challenge of developing point-of-care viral load assays. ..
    THOMAS APPLE; Fiscal Year: 1993
    ..We will, thus, determine the optimal preparation and processing conditions which will lead to advanced materials for prothesis, neural and biochemical use...
  7. Modeling the neuronal activations induced by transcranial magnetic stimulation
    FELIPE SANTIAGO SALINAS; Fiscal Year: 2011
    ..By the modeling the electric fields produced by TMS we can better understand the mechanisms of neuronal activation, including how a particular disease/disorder may be affecting the nervous system. ..
  8. Biophysics of Acupuncture: Electrical Properties of Loose Connective Tissue
    Andrew Ahn; Fiscal Year: 2009
    ..Each of these skills will be critical to the candidate's long-term goal of becoming an independent clinical investigator with a focus on the biophysics of acupuncture. ..
  9. Conductivity-weighted ultrasound for cancer detection
    K Kirk Shung; Fiscal Year: 2010
    ..EMAI produces conductivity-weighted ultrasound which will potentially improve diagnostic performance in cancer screening, and may be especially useful for screening and diagnosing breast cancer. ..
    John Webster; Fiscal Year: 2002
    ..In vitro tests on myocardium will yield physical parameters of electric conductivity, and thermal conduction, capacity, and heat convection variation throughout the endocardium...
  11. Breast Cancer Diagnosis by Electrical Impedance Imaging
    JONATHAN NEWELL; Fiscal Year: 2009
    ..Success of such a trial would reduce the need for biopsy and increase the detection of tumors at an earlier stage, which would reduce the morbidity and mortality of breast cancer. ..
    JONATHAN NEWELL; Fiscal Year: 1990
    ..Full advantage of this flexibility is achieved by the use of the adaptive current algorithm which selects the optimal current pattern to apply based upon the observed unknown conductivities...
  13. MRI-Guided, Robotically Controlled Cardiac Ablation
    John Pauly; Fiscal Year: 2009
    ..This research also initially targets atrial fibrillation as it is very common (1 in 4 Americans develop it in their lifetime), leads to 1/3 of strokes, and there is a need for a successful method to cure it less invasively. ..
    Pavel Smejtek; Fiscal Year: 1990
  15. 3-D Microwave Imaging System for Breast Cancer Detection
    Qing Liu; Fiscal Year: 2006
  16. Nanowire DNA hybridization sensor
    R Daniels; Fiscal Year: 2004
    ..abstract_text> ..
    William Stillwell; Fiscal Year: 1991
    ..Mitochondrial properties to be followed as a function of age will include lipid analysis, respiratory control index and P/O ratios, membrane fluidity, lipid peroxidation, permeability to protons and electrical conductivity...
  18. Combined Ultrasound and Electrical Impedance Tomography
    JONATHAN NEWELL; Fiscal Year: 2006
    ..This would reduce morbidity and mortality. [unreadable] [unreadable] [unreadable]..
  19. Conductive Bioceramic Coatings for Neural Prostheses
    FRANCIS KEOHAN; Fiscal Year: 2004
    ..Phase II objectives would include optimization of coatings for processability, electrical properties, and physiological compatibility, and chronic implantation testing. ..
  20. Thermoacoustic and Inverse Scattering Breast Cancer Scanner
    Steven Johnson; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  21. The Osteoblastic Monolayer as a 'Gatekeeper' in Bone
    MELISSA KNOTHE TATE; Fiscal Year: 2003
    ..This study is expected to provide insight into new strategies for treatment of bone diseases such as osteoporosis and osteoarthritis. ..
    K JEFFREY ERIKSEN; Fiscal Year: 1999
    ..abstract_text> ..
  23. Biomechanical Characterization of Human Cartilaginous End-Plate
    Hai Yao; Fiscal Year: 2010
    James Wefel; Fiscal Year: 2005
    ..The collaborative efforts of the three research-intensive Universities, the long- standing expertise and diverse populations offer a unique combination of resources for this P01. ..
    Weiyong Gu; Fiscal Year: 2002
    ..The results will be useful for the future development of theoretical modeling as well as minimally invasive diagnostic tools for disc degeneration. ..
  26. Elastomeric Multi-Poled Neuroprosthetic Devices for Chronic Implantation
    FRANCIS KEOHAN; Fiscal Year: 2006
    ..The broader impact to society of this new technology would be more effective treatments for neurological disorders including Parkinson's disease, epilepsy, deafness, stroke, and paralysis. [unreadable] [unreadable] [unreadable]..
  27. Simulation of Therapeutic ERCP
    Kevin Kunkler; Fiscal Year: 2003
    ..Clinical experts will provide formative evaluations, and a construct validity study will test whether the simulator can discriminate among experts, intermediates, and novices. ..
    Gordon Tollin; Fiscal Year: 2004
    ..These studies have broad implications for membrane-based processes important in many disease states. ..
  29. Detection of neonatal ventricular hemorrhage using EIT
    Rosalind Sadleir; Fiscal Year: 2006
    ..These data will be analyzed to determine the best way of separating artifacts produced by shape changes and other body impedance changes from the bleeding process. ..
  30. Biophysical Modeling of Solute Transport in Human IVD
    Weiyong Gu; Fiscal Year: 2008
    ..A plan for sharing and disseminating the theory, techniques, and data developed in this research is also included. [unreadable] [unreadable]..
  31. Novel Quantitative Technology for Tissue Engineering
    Chun Yuh Charles Huang; Fiscal Year: 2010
    ..In this project, a new bioreactor system will be designed and fabricated. New methods and techniques for characterizing of mechano-electrochemical properties of the engineered tissue will be developed. ..
  32. Microwave Thermal Monitoring for Breast Hyperthermia
    PAUL MEANEY; Fiscal Year: 2003
    ..It will set the stage for future treatment/monitoring systems targeting other anatomical sites. ..
  33. Molecular Mechanisms of Na Channel Slow Inactivation
    ARIE STRUYK; Fiscal Year: 2005
    ..abstract_text> ..
  34. Microwave Thermal Monitoring for Breast Hyperthermia
    PAUL MEANEY; Fiscal Year: 2002
    ..It will set the stage for future treatment/monitoring systems targeting other anatomical sites. ..
  35. Putting Molecular Dynamics to the Test: Ion Permeation
    Olaf Andersen; Fiscal Year: 2008
    ..abstract_text> ..
  36. A Microfluidic Platform for Early Detection and Prognostication of Cancer
    Aaron Wheeler; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  37. RBC Ion Transporters as Hemoglobinopathy Risk Modifiers
    Seth Alper; Fiscal Year: 2009
    ..The proposed experiments will increase understanding of sickle cell disease and thalassemia by providing mouse models for genetic tests of new drug therapies under development for near-term clinical testing. ..
    Brad S Rothberg; Fiscal Year: 2010
    ..These experiments will enable the resolution of conformational steps in the Ca2+-dependent gating pathway that cannot be resolved using electrophysiological or X-ray experiments. ..
  39. Wearable Organic Electric Film RFID Sensors for Monitoring of Airborne Toxicants
    Radislav A Potyrailo; Fiscal Year: 2010
    ..This new sensing approach will provide a wearable, cost-effective, selective sensor for de- tection of toxic volatile species. ..
    James F Rusling; Fiscal Year: 2010
    ..In addition to achieving our specific aims, this project should provide fundamental guidance for fabrication of sensitive microarray devices for a wide variety of biomedical applications. ..
    Andrew Harris; Fiscal Year: 2009
    ..In the present proposal, this analysis will be applied to Cx32 and Cx26, defects in which cause X-linked Charcot-Marie-Tooth disease neuropathy and sensorineural deafness, respectively. ..
  42. Novel Mechanism of Uranium Reduction Via Microbial Nanowires
    Gemma Reguera; Fiscal Year: 2011
    THOMAS DECOURSEY; Fiscal Year: 2008
    ..5) We will identify the proton channel molecule and gene. ..
  44. Electrowetting Sample Prep for MALDI Mass Spectrometry
    Aaron Wheeler; Fiscal Year: 2005
    ..If successful, this will be a major advance over existing technologies, which do not have the capacity to combine high-throughput arrays with sample processing. ..
  45. Multi-slice Perfusion MR Imaging of the Human Kidney
    H Gach; Fiscal Year: 2004
    ..abstract_text> ..
  46. Soy Isoflavones on NO Production in Postmenopausal Women
    William Wong; Fiscal Year: 2003
    ..3 % pool/h in NO production, 0.2 mmol/d in urinary nitrate excretion, 1 mmHg/mL/min in arterial compliance, 3 mL.min-1.100 mL forearm-1 in forearm bloodflow, and8 mmHg in diastolic blood pressure. ..
    THOMAS DECOURSEY; Fiscal Year: 2003
    ..Demonstration that H+ current fluctuations result from stochastic gating of H+ channels will provide strong evidence that the molecule is an ion channel rather than a carrier. ..
    BHANU JENA; Fiscal Year: 2003
    ..These studies will further our understanding of the exocytotic fusion machinery in pancreatic acinar cells, contributing to our understanding of this vital cellular process. ..
    Christopher Sotak; Fiscal Year: 2004
    ..Junior investigators will be included in the oral presentations. A special effort will be made to use financial student support to facilitate the attendance of women, minorities, and the disabled. ..
    PAUL BOTTOMLEY; Fiscal Year: 2002
    ..The availability of thousands of clinical MRI scanners offers a great opportunity for advancing 23Na MRI as a tool for assessing sodium pump function in human heart disease. ..
    Andrew Harris; Fiscal Year: 2002
    ..Such defects will result in abnormal (i.e., greater or lesser) intercellular signaling molecules. The proposed studies address how this may occur. ..
  52. Colon Barrier Breakdown in the Elderly
    James Mullin; Fiscal Year: 2005
    ..Changes in membrane composition/fluidity are known to affect paracellular permeability in general, and tight junction proteins specifically. ..
    Bradley Roth; Fiscal Year: 2005
    ..Each hypothesis is motivated by experimental data, and the goal of the theoretical simulations is to interpret these data. ..
    Erno Lindner; Fiscal Year: 2008
    ..Milestone: Test MAIAs in standard serum samples. (4) Test the multi-analyte immunoassay in patient samples. Milestone: Validate the novel MAIAs. [unreadable] [unreadable] [unreadable]..
  55. Soy Isoflavone Supplementation and Mammographic Density in Postmenopausal Women
    William Wong; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  56. MR Studies of Myocardial Creatine Kinase Metabolism
    PAUL BOTTOMLEY; Fiscal Year: 2007
  57. Ca2+ Sparks as Regulators of Airway Contractility
    Ronghua Zhuge; Fiscal Year: 2007
    ..We expect that these studies will provide new knowledge which could lead to development of novel therapeutic approaches for asthma and other bronchospasitc disorders. ..
    Seth Alper; Fiscal Year: 2007
    ..5. Define aspects of transcriptional and translational regulation of AE gene products in kidney of mutant and parental mouse strains and in cultured kidney cells. ..
  59. Biosensor for Contaminant-Free Platelets
    Edward Elson; Fiscal Year: 2002
    ..abstract_text> ..
    Andrew Harris; Fiscal Year: 2006
    ..The information obtained will be informative regarding connexin channel function in other contexts, and will lead to insights about mechanisms of selectivity among cytoplasmic permeants. ..
  61. Neuronal variability and invariants
    Adam Taylor; Fiscal Year: 2006
    ..This work will provide important insights about how nervous systems regulate themselves to maintain proper function. ..
    BHANU JENA; Fiscal Year: 2001
    ..The biochemical composition of the "new structure" will be determined by microsequencing electrophoretically resolved proteins immunoisolated from brain tissue, using antibodies to the SNARE proteins. ..