Top Publications

  1. pmc New low-viscosity overlay medium for viral plaque assays
    Mikhail Matrosovich
    Institute of Virology, Philipps University, Hans Meerwein Str, 3, 35043 Marburg, Germany
    Virol J 3:63. 2006
  2. ncbi Barrier properties of mucus
    Richard A Cone
    Biophysics Department, Johns Hopkins University, and ReProtect, Inc, Baltimore MD, USA
    Adv Drug Deliv Rev 61:75-85. 2009
  3. pmc Macromolecular size-and-shape distributions by sedimentation velocity analytical ultracentrifugation
    Patrick H Brown
    Protein Biophysics Resource, Division of Bioengineering and Physical Science, ORS, Office of the Director, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biophys J 90:4651-61. 2006
  4. ncbi Human telomere sequence DNA in water-free and high-viscosity solvents: G-quadruplex folding governed by Kramers rate theory
    Ford M Lannan
    School of Chemistry and Biochemistry, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    J Am Chem Soc 134:15324-30. 2012
  5. ncbi Up to 50-fold increase in urine viscosity with iso-osmolar contrast media in the rat
    Erdmann Seeliger
    Institute of Vegetative Physiology, Charite Universitatsmedizin Berlin, CCM, Tucholskystr 2, D 10117 Berlin, Germany
    Radiology 256:406-14. 2010
  6. ncbi Viscosity of iodinated contrast agents during renal excretion
    Gregor Jost
    TRG Diagnostic Imaging, Bayer Schering Pharma AG, Berlin, Germany
    Eur J Radiol 80:373-7. 2011
  7. ncbi The effects of food viscosity on bite size, bite effort and food intake
    R A de Wijk
    Top Institute for Food and Nutrition, 6700 AN Wageningen, The Netherlands
    Physiol Behav 95:527-32. 2008
  8. ncbi Mechanics of nectar feeding in the orchid bee Euglossa imperialis: pressure, viscosity and flow
    Brendan J Borrell
    Department of Integrative Biology, University of California, Berkeley, CA 94720 3140, USA
    J Exp Biol 209:4901-7. 2006
  9. ncbi Experimental validation of a time-domain-based wave propagation model of blood flow in viscoelastic vessels
    David Bessems
    Department of Biomedical Engineering, Eindhoven University of Technology, P O Box 513, 5600 MB Eindhoven, The Netherlands
    J Biomech 41:284-91. 2008
  10. ncbi Overexpression of myosin IB in living Entamoeba histolytica enhances cytoplasm viscosity and reduces phagocytosis
    Sabrina Marion
    Unité de Biologie Cellulaire du Parasitisme, INSERM U389, Institut Pasteur, 28 rue du Dr Roux 75724, Paris Cedex 15, France
    J Cell Sci 117:3271-9. 2004

Detail Information

Publications300 found, 100 shown here

  1. pmc New low-viscosity overlay medium for viral plaque assays
    Mikhail Matrosovich
    Institute of Virology, Philipps University, Hans Meerwein Str, 3, 35043 Marburg, Germany
    Virol J 3:63. 2006
    ..To overcome the pitfalls of known overlays, we tested suspensions of microcrystalline cellulose Avicel RC/CLtrade mark as overlay media in the plaque and plaque-inhibition assay of influenza viruses...
  2. ncbi Barrier properties of mucus
    Richard A Cone
    Biophysics Department, Johns Hopkins University, and ReProtect, Inc, Baltimore MD, USA
    Adv Drug Deliv Rev 61:75-85. 2009
    ..These viruses are smaller than the mucus mesh spacing, and have surfaces that do not stick to mucus. They form a useful model for developing NP for mucosal drug delivery...
  3. pmc Macromolecular size-and-shape distributions by sedimentation velocity analytical ultracentrifugation
    Patrick H Brown
    Protein Biophysics Resource, Division of Bioengineering and Physical Science, ORS, Office of the Director, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biophys J 90:4651-61. 2006
    ..We show that this can be used to determine average molar masses of macromolecules and characterize macromolecular distributions, without the approximation of any scaling relationship between hydrodynamic and thermodynamic parameters...
  4. ncbi Human telomere sequence DNA in water-free and high-viscosity solvents: G-quadruplex folding governed by Kramers rate theory
    Ford M Lannan
    School of Chemistry and Biochemistry, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    J Am Chem Soc 134:15324-30. 2012
    ..We present studies of HTS DNA folding in an anhydrous, high viscosity deep eutectic solvent (DES) comprised of choline choride and urea...
  5. ncbi Up to 50-fold increase in urine viscosity with iso-osmolar contrast media in the rat
    Erdmann Seeliger
    Institute of Vegetative Physiology, Charite Universitatsmedizin Berlin, CCM, Tucholskystr 2, D 10117 Berlin, Germany
    Radiology 256:406-14. 2010
    To compare changes in urinary viscosity in the renal tubules following administration of a high-viscosity iso-osmolar contrast agent (iodixanol) to that observed following administration of a less viscous, higher osmolar contrast agent (..
  6. ncbi Viscosity of iodinated contrast agents during renal excretion
    Gregor Jost
    TRG Diagnostic Imaging, Bayer Schering Pharma AG, Berlin, Germany
    Eur J Radiol 80:373-7. 2011
    ..molecular structure into monomeric and dimeric CAs and have at comparable iodine concentrations a different viscosity and osmolality...
  7. ncbi The effects of food viscosity on bite size, bite effort and food intake
    R A de Wijk
    Top Institute for Food and Nutrition, 6700 AN Wageningen, The Netherlands
    Physiol Behav 95:527-32. 2008
    Two studies investigated the effect of a food's viscosity on bite size, bite effort and food intake using a standardized protocol in which subjects sipped through a straw every 20 s for a period of 15 min from one of two products, a ..
  8. ncbi Mechanics of nectar feeding in the orchid bee Euglossa imperialis: pressure, viscosity and flow
    Brendan J Borrell
    Department of Integrative Biology, University of California, Berkeley, CA 94720 3140, USA
    J Exp Biol 209:4901-7. 2006
    ..Nectar intake rate was measured as a function of sucrose concentration (5-75% w/w), nectar viscosity (2-80 mPa s), and ambient pressure (101-40 kPa). Intake rate declines from about 1.2 mul s(-1) to 0...
  9. ncbi Experimental validation of a time-domain-based wave propagation model of blood flow in viscoelastic vessels
    David Bessems
    Department of Biomedical Engineering, Eindhoven University of Technology, P O Box 513, 5600 MB Eindhoven, The Netherlands
    J Biomech 41:284-91. 2008
  10. ncbi Overexpression of myosin IB in living Entamoeba histolytica enhances cytoplasm viscosity and reduces phagocytosis
    Sabrina Marion
    Unité de Biologie Cellulaire du Parasitisme, INSERM U389, Institut Pasteur, 28 rue du Dr Roux 75724, Paris Cedex 15, France
    J Cell Sci 117:3271-9. 2004
    ..Using this technique, we showed that overexpression of myosin IB led to an increase in cytoplasm viscosity, which correlated with a delay in initiating human cell phagocytosis...
  11. ncbi Searching for meaningful differences in viscosity
    Catriona M Steele
    Dysphagia 20:336-8. 2005
  12. ncbi High-viscosity hydroxypropylmethylcellulose blunts postprandial glucose and insulin responses
    Kevin C Maki
    Provident Clinical Research, 1000 W 1st St, Bloomington, IN 47403, USA
    Diabetes Care 30:1039-43. 2007
    High-viscosity hydroxypropylmethylcellulose (HV-HPMC) is a modified cellulose fiber that produces a viscous gel in the gastrointestinal tract...
  13. ncbi Beverage viscosity is inversely related to postprandial hunger in humans
    R D Mattes
    Department of Foods and Nutrition, Purdue University, Room 212, 1264 Stone Hall, West Lafayette, IN 47907 1264, USA
    Physiol Behav 74:551-7. 2001
    ..The present study attempted to isolate an influence of viscosity. At weekly intervals, 84 adults ingested 325-ml (220 kcal) shakes that were matched on weight, volume, ..
  14. pmc The optical stretcher: a novel laser tool to micromanipulate cells
    J Guck
    Center for Nonlinear Dynamics, Department of Physics, University of Texas at Austin, Texas 78712, USA
    Biophys J 81:767-84. 2001
    ..The magnitude of the deforming forces in the optical stretcher thus bridges the gap between optical tweezers and atomic force microscopy for the study of biologic materials...
  15. ncbi The impact of the viscosity and osmolality of iodine contrast agents on renal elimination
    Gregor Jost
    TRG Diagnostic Imaging, Bayer Schering Pharma AG, Berlin, Germany
    Invest Radiol 45:255-61. 2010 and a high safety profile; however, according to a large retrospective study (Swedish registry), the viscosity of CAs may have an underestimated impact on renal failure...
  16. ncbi Controlled release of metronidazole benzoate from poly epsilon-caprolactone electrospun nanofibers for periodontal diseases
    Maedeh Zamani
    Department of Textile Engineering, Isfahan University of Technology, Isfahan, Iran
    Eur J Pharm Biopharm 75:179-85. 2010 increase in the DCM:DMF ratio led to a decrease in the solution conductivity and an increase in the solution viscosity as well as in the nanofibers diameter...
  17. ncbi Viscosity and non-Newtonian features of thickened fluids used for dysphagia therapy
    Mark O'Leary
    Dept of Mechanical Engineering, University College London, Torrington Place, London, UK
    J Food Sci 75:E330-8. 2010
    ..on granulated maize starch are widely used in the care of patients with swallowing difficulties, increasing viscosity of consumed fluids...
  18. pmc Single molecule measurements of F1-ATPase reveal an interdependence between the power stroke and the dwell duration
    David Spetzler
    School of Life Sciences, Arizona State University, P O Box 874501, Tempe, Arizona 85287 4501, USA
    Biochemistry 48:7979-85. 2009
    ..varied using different sizes of gold nanorods attached to the rotating gamma subunit and/or by increasing the viscosity of the medium using PEG-400, a noncompetitive inhibitor of ATPase activity...
  19. ncbi Oral and oropharyngeal perceptions of fluid viscosity across the age span
    Christina H Smith
    Department of Human Communication Science, University College London, London, England
    Dysphagia 21:209-17. 2006
    ..However, it is not known what variations in viscosity can be perceived in the oral cavity or oropharynx or if age affects oral and oropharyngeal perceptions of fluid ..
  20. ncbi Non-invasive measurement of brain viscoelasticity using magnetic resonance elastography
    Ingolf Sack
    Institute of Radiology, Charite Universitatsmedizin Berlin, Berlin, Germany
    NMR Biomed 21:265-71. 2008
    ..time-resolved phase-difference wave images were recorded within 60 s and analyzed for shear stiffness and shear viscosity. Six healthy volunteers (six men; mean age 34...
  21. pmc The impact of food viscosity on eating rate, subjective appetite, glycemic response and gastric emptying rate
    Yong Zhu
    Department of Food Science and Human Nutrition, Iowa State University, Ames, Iowa, USA
    PLoS ONE 8:e67482. 2013
    ..However, whether a subtle change in viscosity of a semi-solid food would have a similar effect on appetite is unknown...
  22. ncbi The rheology of liquids: a comparison of clinicians' subjective impressions and objective measurement
    Catriona M Steele
    Oral Dynamics Laboratory, Graduate Department of Speech Language Pathology, University of Toronto, Toronto, Ontario, Canada
    Dysphagia 18:182-95. 2003
    ..Fifty speech-language pathologists ranked the liquids in order of perceived viscosity, based on their interpretation of the product packaging and label...
  23. ncbi Tensile force transmission in human patellar tendon fascicles is not mediated by glycosaminoglycans
    René B Svensson
    Institute of Sports Medicine Copenhagen, Bispebjerg Hospital and Center for Healthy Aging, University of Copenhagen, Denmark
    Connect Tissue Res 52:415-21. 2011
    ..The effect of deformation rate was not modulated by the treatment either, indicating no effect on viscosity. These results suggest that GAGs cannot be considered mediators of tensile force transmission in the human ..
  24. ncbi Viscoelastic properties of model segments of collagen molecules
    Alfonso Gautieri
    Laboratory for Atomistic and Molecular Mechanics, Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave, Room 1 235A and B, Cambridge, MA, USA
    Matrix Biol 31:141-9. 2012
    ..a nonlinear viscoelastic behavior, with a Young's modulus increasing from 6 to 16GPa (for strains up to 20%), a viscosity of 3.84.±0.38Pa·s, and a relaxation time in the range of 0.24-0.64ns...
  25. ncbi Application of a factorial design to the study of the flow behavior, spreadability and transparency of a Carbopol ETD 2020 gel. Part II
    M D Contreras
    Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Granada, Campus of Cartuja, E 18071 Granada, Spain
    Int J Pharm 234:149-57. 2002
    ..of Carbopol ETD 2020, ethanol and glycerine) on flow parameters (Casson's yield value (tau(c)), Casson's viscosity (eta(c)) and apparent viscosity at 125 s-1 (eta(ap.) 125 s-1), spreadability, and transparency...
  26. pmc Measurement of local viscoelasticity and forces in living cells by magnetic tweezers
    A R Bausch
    Physik Department E22 Biophysics group, Technische Universität M unchen, D 85748 Garching
    Biophys J 76:573-9. 1999
    ..The effective viscosity of the cytoplasm exhibits a relatively sharp distribution about an average of eta = 210 Pa s (+/- 143 Pa s)...
  27. ncbi Cross-linking molecules modify composite actin networks independently
    K M Schmoller
    Lehrstuhl für Biophysik E27, Technische Universitat Munchen, James Franck Strasse 1, 85748 Garching, Germany
    Phys Rev Lett 101:118102. 2008
    ..The outnumbering ABP dictates the local network structure and therefore also dominates the macromechanical network response...
  28. ncbi Application of simultaneous saccharification and fermentation (SSF) from viscosity reducing of raw sweet potato for bioethanol production at laboratory, pilot and industrial scales
    Liang Zhang
    Environmental Microbiology Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, Sichuan 610041, PR China
    Bioresour Technol 102:4573-9. 2011
    ..06 g/L, 4.89 g/L/h and 91.24%) and industrial scale (97.94 g/L, 4.19 g/L/h and 91.27%). When scaled up, the viscosity caused resistance to fermentation parameters, 1...
  29. pmc The viscoelasticity of membrane tethers and its importance for cell adhesion
    Julia Schmitz
    Applied Physics and Biophysics, Ludwig Maximilians University, 80799 Munich, Germany
    Biophys J 95:1448-59. 2008
    ..anchorage of the receptor, which is described by the tether stiffness, the membrane rigidity, and the membrane viscosity. The measurements relate to a tether stiffness of k(t) = 1...
  30. ncbi Clinical performance of a mid-viscosity artificial tear for dry eye treatment
    Peter A Simmons
    Eye Care Research and Development, Allergan LLC, Irvine, CA 92612, USA
    Cornea 26:294-302. 2007
    We report the results of 3 studies conducted to evaluate the performance of a 1.0% carboxymethylcellulose (CMC) mid-viscosity artificial tear compared to currently marketed low-viscosity tears.
  31. ncbi Ultrastructural architecture and mechanical properties of attachment pads in Tettigonia viridissima (Orthoptera Tettigoniidae)
    S Gorb
    Biochemistry Department, Max Planck Institute of Developmental Biology, Tubingen, Germany
    J Comp Physiol A 186:821-31. 2000
    ..88+/-0.616 s and tau2 =41.2 +/- 9.95 s. Low stiffness of material studied here aids in surface replication and increase of area of real contact between the pad and the underlying substrate...
  32. pmc A distinct DGAT with sn-3 acetyltransferase activity that synthesizes unusual, reduced-viscosity oils in Euonymus and transgenic seeds
    Timothy P Durrett
    Department of Plant Biology, Michigan State University, East Lansing, MI 48824, USA
    Proc Natl Acad Sci U S A 107:9464-9. 2010
    ..the sn-3 acetyl group imparts acTAGs with different physical and chemical properties, such as a 30% reduction in viscosity, compared to lcTAGs...
  33. ncbi Viscosity of oat bran-enriched beverages influences gastrointestinal hormonal responses in healthy humans
    Kristiina R Juvonen
    Department of Clinical Nutrition, Food and Health Research Centre, School of Public Health and Clinical Nutrition, University of Kuopio, 70211 Kuopio, Finland
    J Nutr 139:461-6. 2009
    ..However, effects of fiber viscosity on modulation of satiety-related gut hormone responses are largely unknown...
  34. pmc Experimental evidence for a frustrated energy landscape in a three-helix-bundle protein family
    Beth G Wensley
    Department of Chemistry, University of Cambridge, MRC Centre for Protein Engineering, Lensfield Rd, Cambridge CB2 1EW UK
    Nature 463:685-8. 2010
  35. ncbi In vivo brain viscoelastic properties measured by magnetic resonance elastography
    Michael A Green
    Prince of Wales Medical Research Institute, UNSW, Sydney, Australia
    NMR Biomed 21:755-64. 2008
    ..1 kPa) to be significantly stiffer than white matter (2.7 kPa). The first in vivo loss modulus (G'') measurements show no significant difference between grey matter (2.5 kPa) and white matter (2.5 kPa)...
  36. ncbi Simultaneous transgenic suppression of LePG and LeExp1 influences fruit texture and juice viscosity in a fresh market tomato variety
    Ann L T Powell
    Department of Vegetable Crops, University of California, Davis, California 95616
    J Agric Food Chem 51:7450-5. 2003
    ..disassembly is associated with loss of fresh fruit firmness as well as with loss of processed tomato product viscosity. Several enzymes contribute to cell wall polysaccharide disassembly...
  37. ncbi Oral cancer diagnosis by mechanical phenotyping
    Torsten W Remmerbach
    Department of Oral, Maxillofacial and Facial Plastic Surgery, University of Leipzig, Leipzig, Germany
    Cancer Res 69:1728-32. 2009
    ..It could in principle be applied to any cancer to aid conventional diagnostic procedures...
  38. ncbi Effect of resin viscosity and enamel beveling on the clinical performance of Class V composite restorations: three-year results
    Luiz Narciso Baratieri
    Department of Operative Dentistry, Universidade Federal de Santa Catarina, Florianopolis, SC Brazil
    Oper Dent 28:482-7. 2003
    ..Enamel beveling and composite viscosity appeared to not significantly affect the clinical performance of Class V non-retentive composite restorations ..
  39. ncbi The impact of aging and gender on brain viscoelasticity
    Ingolf Sack
    Department of Radiology, Charite University Medicine Berlin, Campus Charite Mitte, Berlin, Germany
    Neuroimage 46:652-7. 2009
    ..5 Hz revealed for the first time how physiological aging changes the global viscosity and elasticity of the brain...
  40. ncbi Validation of a one-dimensional model of the systemic arterial tree
    Philippe Reymond
    Laboratory of Hemodynamics and Cardiovascular Technology, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    Am J Physiol Heart Circ Physiol 297:H208-22. 2009
    ..The study constitutes a first validation of the complete 1-D model using human pressure and flow data and supports the applicability of the 1-D model in the human circulation...
  41. ncbi Reconfigurable microfluidic integration of a dual-beam laser trap with biomedical applications
    Bryan Lincoln
    Institut für Experimentalphysik I, Universitat Leipzig, Linnestr 5, 04103, Leipzig, Germany
    Biomed Microdevices 9:703-10. 2007
    ..Possible applications include the cytological diagnosis of cancer and the gentle and marker-free sorting of stem cells from heterogeneous populations for therapeutic cell-based approaches in regenerative medicine...
  42. ncbi Beta-glucan from two sources of oat concentrates affect postprandial glycemia in relation to the level of viscosity
    Shirin Panahi
    University of Toronto, Faculty of Medicine, Department of Nutritional Sciences, Toronto, ON, M5S 3E2, Canada
    J Am Coll Nutr 26:639-44. 2007
    ..This effect seems to be related to its rheological properties including viscosity. We examined the intra-fiber variability between two different processing methods of concentrating beta-glucan ..
  43. ncbi In vitro and in vivo evaluation of Pluronic F127-based ocular delivery system for timolol maleate
    A H El-Kamel
    Department of Pharmaceutics, Faculty of Pharmacy, King Saud University, Women Students Medical Studies and Science Sections, PO Box 22452, 11495, Riyadh, Saudi Arabia
    Int J Pharm 241:47-55. 2002 attempt to reduce the concentration of PF127 without compromising the in situ gelling capabilities, various viscosity enhancing agents were added to PF127 solution containing 0.5% TM...
  44. ncbi Microemulsion-based media as novel drug delivery systems
    M J Lawrence
    Department of Pharmacy, King s College London, Franklin Wilkins Building, 150 Stamford Street, SE1 9NN, London, UK
    Adv Drug Deliv Rev 45:89-121. 2000
    ..The use of microemulsions and closely related microemulsion-based systems as drug delivery vehicles is reviewed, with particular emphasis being placed on recent developments and future directions...
  45. ncbi Association between rmpA and magA genes and clinical syndromes caused by Klebsiella pneumoniae in Taiwan
    Wen Liang Yu
    Department of Intensive Care Medicine, Chi Mei Medical Center, Yungkang City, Tainan, Taiwan
    Clin Infect Dis 42:1351-8. 2006
    ..However, the association of rmpA with K. pneumoniae clinical syndromes is unreported. We aimed to investigate the clinical correlation between rmpA and primary Klebsiella abscess, focusing on sites other than the liver...
  46. ncbi Viscosity of contrast media perturbs renal hemodynamics
    Erdmann Seeliger
    Institut für Vegetative Physiologie, Berlin, Germany
    J Am Soc Nephrol 18:2912-20. 2007
    ..concentrations but differing physiocochemical properties: the high-osmolality iopromide was compared to the high-viscosity iodixanol...
  47. pmc Quantitative analysis of the viscoelastic properties of thin regions of fibroblasts using atomic force microscopy
    R E Mahaffy
    Department of Physics, Center for Nonlinear Dynamics, University of Texas, Austin, Texas, USA
    Biophys J 86:1777-93. 2004
    ..Applying this decomposition and Tu's and Chen's finite depth models allow us to obtain viscoelastic signatures in a frequency range from 50 to 300 Hz, showing a rubber plateau-like behavior...
  48. pmc Viscoelastic properties of human mesenchymally-derived stem cells and primary osteoblasts, chondrocytes, and adipocytes
    Eric M Darling
    Department of Surgery, Duke University Medical Center Durham, NC 27710, USA
    J Biomech 41:454-64. 2008
    ..Furthermore, the identification of mechanical properties distinct to stem cells could result in more successful sorting procedures to enrich multipotent progenitor cell populations...
  49. pmc Cell motility and local viscoelasticity of fibroblasts
    S Park
    Department of Physics, Texas Materials Institute, and Center for Nano and Molecular Science, University of Texas, Austin, Texas 78712, USA
    Biophys J 89:4330-42. 2005
    ..The correlation between the enhanced motility and the decrease in viscoelastic moduli supports the Elastic Brownian Ratchet model for driving lamellipodia extension...
  50. ncbi Nanoscale hydrodynamics: enhanced flow in carbon nanotubes
    Mainak Majumder
    Chemical and Materials Engineering Department, University of Kentucky, Lexington, Kentucky 40506, USA
    Nature 438:44. 2005
    ..This high fluid velocity results from an almost frictionless interface at the carbon-nanotube wall...
  51. ncbi High-viscosity liquid meal accelerates gastric emptying
    Y Shimoyama
    Department of Endoscopy and Endoscopic Surgery, Gunma University Hospital, Gunma, Japan
    Neurogastroenterol Motil 19:879-86. 2007
    Adding pectin to an elemental formula increases its viscosity through gelatinization, thus presumably preventing gastro-oesophageal reflux and aspiration pneumonia...
  52. ncbi The cell as a material
    Karen E Kasza
    Department of Physics and DEAS, Harvard University, Cambridge, MA 02138, USA
    Curr Opin Cell Biol 19:101-7. 2007
    ..These networks are highly nonlinear, with an elastic modulus that depends sensitively on applied stress. Theories can account for some of the measured properties, but a complete model remains elusive...
  53. ncbi Effect of meal viscosity and nutrients on satiety, intragastric dilution, and emptying assessed by MRI
    L Marciani
    Magnetic Resonance Centre, School of Physics and Astronomy, Nottingham NG7 2RD, United Kingdom
    Am J Physiol Gastrointest Liver Physiol 280:G1227-33. 2001
    ..magnetic resonance imaging techniques in 12 healthy subjects with four polysaccharide test meals of varying viscosity and nutrient content as follows: 1) low-viscosity nonnutrient, 2) low-viscosity nutrient, 3) high-viscosity ..
  54. ncbi Interaction between PEVK-titin and actin filaments: origin of a viscous force component in cardiac myofibrils
    M Kulke
    Institute of Physiology, University of Heidelberg, Heidelberg, Germany
    Circ Res 89:874-81. 2001
    ..We conclude that interaction between PEVK-titin and actin occurs in the sarcomere and may cause viscous drag during diastolic stretch of cardiac myofibrils. The interaction could also oppose shortening during contraction...
  55. ncbi Prebiotic oligosaccharides reduce stool viscosity and accelerate gastrointestinal transport in preterm infants
    Walter A Mihatsch
    Department of Paediatrics, Deaconry Hospital, Schwaebisch Hall, Germany
    Acta Paediatr 95:843-8. 2006
    ..We hypothesized that GosFos would: (1) reduce stool viscosity and (2) accelerate gastrointestinal transport.
  56. ncbi In vitro and in vivo characterization of a potential universal placebo designed for use in vaginal microbicide clinical trials
    Deborah Tien
    Biosyn, Inc, Huntingdon Valley, PA 19006, USA
    AIDS Res Hum Retroviruses 21:845-53. 2005
  57. pmc High viscosity and anisotropy characterize the cytoplasm of fungal dormant stress-resistant spores
    J Dijksterhuis
    Department of Applied and Industrial Mycology, Centraalbureau voor Schimmelcultures, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    Eukaryot Cell 6:157-70. 2007
    ..Here, physical parameters of the cytoplasm of these types of spores were compared. Cytoplasmic viscosity and level of anisotropy as judged by spin probe studies (electron spin resonance) were extremely high in dormant ..
  58. pmc Mucin biopolymers as broad-spectrum antiviral agents
    Oliver Lieleg
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States
    Biomacromolecules 13:1724-32. 2012
    ..Our findings suggest that purified mucins may be used as a broad-range antiviral supplement to personal hygiene products, baby formula or lubricants to support our immune system...
  59. ncbi Effects of intra-articular sodium pentosan polysulfate and glucosamine on the cytology, total protein concentration and viscosity of synovial fluid in horses
    C Kwan
    Research and Clinical Training Unit, University Veterinary Teaching Hospital, University of Sydney, Camden, NSW, Australia
    Aust Vet J 90:315-20. 2012
    Evaluate synovial fluid cytology, total protein concentration and viscosity after intra-articular administration of combined pentosan polysulfate and glucosamine in horses.
  60. pmc Intrarenal oxygenation by blood oxygenation level-dependent MRI in contrast nephropathy model: effect of the viscosity and dose
    Lu Ping Li
    Department of Radiology Center for Advanced Imaging, NorthShore University Healthsystem, Pritzker School of Medicine, University of Chicago, Chicago, Illinois, USA
    J Magn Reson Imaging 36:1162-7. 2012
    To compare the effects of osmolality versus viscosity of radio-contrast media on intra-renal oxygenation as determined by blood oxygenation level-dependent (BOLD) MRI in a model of contrast induced nephropathy (CIN).
  61. ncbi Genetic analysis of starch paste viscosity parameters in glutinous rice (Oryza sativa L.)
    Chang Jie Yan
    Jiangsu Key Laboratory of Crop Genetics and Physiology, Key Laboratory of Plant Functional Genomics, Ministry of Education of China, Agricultural College of Yangzhou University, 12 East Wenhui Road, Jiangsu, 225009, People s Republic of China
    Theor Appl Genet 122:63-76. 2011
    Starch paste viscosity plays an important role in estimating the cooking, eating, and processing quality of rice. The inheritance of starch paste viscosity in glutinous rice remains undefined...
  62. ncbi Thermoreversible mucoadhesive ophthalmic in situ hydrogel: Design and optimization using a combination of polymers
    Divyesh H Shastri
    Department of Pharmaceutics, K B Institute of Pharmaceutical Education and Research, Gandhinagar, Gujarat 382023, India
    Acta Pharm 60:349-60. 2010
    ..Gelation temperature, gel strength, bioadhesion force, viscosity and in vitro drug release after 1 and 10 h were selected as dependent variables...
  63. pmc Measuring the viscoelastic properties of human platelets with the atomic force microscope
    M Radmacher
    Department of Physics, University of California, Santa Barbara 93106, USA
    Biophys J 70:556-67. 1996
    ..The elastic moduli were in a range of 1-50 kPa measured in the frequency range of 1-50 Hz. Loading forces could be controlled with a resolution of 80 pN and indentations of the platelet could be determined with a resolution of 20 nm...
  64. ncbi Homeostasis of plasma membrane viscosity in fluctuating temperatures
    Alexandre Martinière
    School of Life Sciences, Oxford Brookes University, Headington, Oxford OX3 0BP, UK
    New Phytol 192:328-37. 2011
    ..Reducing temperature should, in the absence of other factors, increase the viscosity of a lipid membrane. We have investigated the effect of temperature variation on plasma membrane (PM) viscosity...
  65. ncbi Viscoelastic constitutive law in large deformations: application to human knee ligaments and tendons
    D P Pioletti
    Hopital Orthopedique de la Suisse Romande, Biomedical Engineering Laboratory, Federal Institute of Technology, Lausanne, Switzerland
    J Biomech 31:753-7. 1998
    ..Three parameters -- two for the elasticity and one for the viscosity -- were enough to precisely fit the non-linear stress strain curves obtained at different strain rates with ..
  66. ncbi Role of pleural viscosity in the differential diagnosis of exudative pleural effusion
    Ozkan Yetkin
    Department of Chest Disease, Inonu University School of Medicine, Malayta, Turkey
    Respirology 12:267-71. 2007
    ..However, a reliable test for determining the aetiology of a pleural effusion is lacking. Pleural viscosity has a high sensitivity and specificity and a high positive and negative predictive value for discriminating ..
  67. pmc Protein-flexibility mediated coupling between photoswitching kinetics and surrounding viscosity of a photochromic fluorescent protein
    Ya Ting Kao
    Department of Chemistry, Columbia University, New York, NY 10027, USA
    Proc Natl Acad Sci U S A 109:3220-5. 2012
    ..that the photoswitching kinetics of the chromophore inside Dronpa is actually slowed down by increasing medium viscosity outside Dronpa...
  68. pmc Viscosity of glass-forming liquids
    John C Mauro
    Science and Technology Division, Corning Incorporated, Corning, NY 14831, USA
    Proc Natl Acad Sci U S A 106:19780-4. 2009
    ..Unfortunately, existing viscosity models, such as the Vogel-Fulcher-Tammann (VFT) and Avramov-Milchev (AM) equations, exhibit systematic error ..
  69. ncbi Scaling form of viscosity at all length-scales in poly(ethylene glycol) solutions studied by fluorescence correlation spectroscopy and capillary electrophoresis
    Robert Holyst
    Institute of Physical Chemistry PAS, Kasprzaka 44 52, 01 224 Warsaw, Poland
    Phys Chem Chem Phys 11:9025-32. 2009
    We measured the viscosity of poly(ethylene glycol) (PEG 6000, 12,000, 20,000) in water using capillary electrophoresis and fluorescence correlation spectroscopy with nanoscopic probes of different diameters (from 1.7 to 114 nm)...
  70. ncbi Increasing viscosity of the intestinal contents alters small intestinal structure and intestinal growth, and stimulates proliferation of enterotoxigenic Escherichia coli in newly-weaned pigs
    D E McDonald
    Division of Veterinary and Biomedical Sciences, Murdoch University, Murdoch, Western Australia 6150, Australia
    Br J Nutr 86:487-98. 2001
    ..sodium carboxymethylcellulose (CMC), in a low-fibre weaning diet was tested to assess the influence of digesta viscosity on the gut in the absence of increased fermentation...
  71. ncbi Endothelial, cardiac muscle and skeletal muscle exhibit different viscous and elastic properties as determined by atomic force microscopy
    A B Mathur
    Center for Cellular and Biosurface Engineering, Department of Biomedical Engineering, Duke University, Box 90281, 136 Hudson Hall, Durham, NC 27708-0281, USA
    J Biomech 34:1545-53. 2001
    ..4 kPa) depending on the location of the cell surface tested. Cardiac and skeletal muscle exhibited nonlinear elastic behavior. These passive mechanical properties are generally consistent with the function of these different cell types...
  72. ncbi Sustained release from lipid-core nanocapsules by varying the core viscosity and the particle surface area
    Eliézer Jäger
    Programa de Pós Graduação em Ciências Farmacêuticas, Faculdade de Farmacia, Universidade Federal do Rio Grande do Sul UFRGS, Porto Alegre, 90610 000 RS, Brazil
    J Biomed Nanotechnol 5:130-40. 2009
    ..46 x 10(4) to 1.06 x 10(4) cm2 x ml(-1)). The presence of SM increased the viscosity of CCT and the IndOEt apparent permeability decreased from 4.26 x 10(-7) to 2...
  73. ncbi A highly sensitive fluorescent viscosity sensor
    Rahimi M Yusop
    School of Chemical Sciences and Food Technology, Faculty of Science and Technology, 43600 Universiti Kebangsaan Malaysia, Selangor, Malaysia
    Bioorg Med Chem Lett 22:5780-3. 2012
    ..the highest quantum yield and was observed to behave as a molecular rotor, displaying marked variations in fluorescent intensities with viscosity and offering possible application in cellular sensing and fluorescent polarisation assays.
  74. ncbi Dietary fibres in the regulation of appetite and food intake. Importance of viscosity
    Mette Kristensen
    Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Rolighedsvej 30, DK 1958 Frederiksberg C, Denmark
    Appetite 56:65-70. 2011
    ..Particularly the ability of some dietary fibres to increase viscosity of intestinal contents offers numerous opportunities to affect appetite regulation...
  75. ncbi Effect of viscosity on appetite and gastro-intestinal hormones
    Nicolien Zijlstra
    Top Institute Food and Nutrition, Wageningen, The Netherlands Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    Physiol Behav 97:68-75. 2009
    In previous studies we showed that higher viscosity resulted in lower ad libitum intake and that eating rate is an important factor...
  76. ncbi Structural deformation of bacterial biofilms caused by short-term fluctuations in fluid shear: an in situ investigation of biofilm rheology
    P Stoodley
    University of Exeter, Department of Biological Sciences, Hatherly Laboratories, Exeter, Devon EX4 4PS, UK
    Biotechnol Bioeng 65:83-92. 1999
    ..The implications of these results for fluid energy losses and the processes of mass transfer and detachment are discussed...
  77. ncbi The effect of bolus viscosity on laryngeal closure in swallowing: kinematic analysis using 320-row area detector CT
    Yoko Inamoto
    Faculty of Rehabilitation, School of Health Sciences, Fujita Health University, 1 98 Dengakugakubo, Kutsukake, Toyoake, Aichi, 470 1192, Japan
    Dysphagia 28:33-42. 2013
    The present study examined the effect of bolus viscosity on the onset of laryngeal closure (relative to hyoid elevation), the duration of laryngeal closure, and other key events of swallowing in ten healthy volunteers...
  78. ncbi Interfacial water at hydrophobic and hydrophilic surfaces: slip, viscosity, and diffusion
    Christian Sendner
    Physik Department, Technische Universitat Munchen, 85748 Garching, Germany
    Langmuir 25:10768-81. 2009
    ..On polar hydrophilic surfaces, in contrast, slip is absent, but the water viscosity is found to be increased within a thin surface layer...
  79. ncbi Imaging intracellular viscosity of a single cell during photoinduced cell death
    Marina K Kuimova
    Chemistry Department, Imperial College London, Exhibition Road, London SW7 2AZ, UK
    Nat Chem 1:69-73. 2009
    ..The efficacy of this treatment depends on the viscosity of the medium through which the cytotoxic agent must diffuse...
  80. ncbi The influence of charge distribution on self-association and viscosity behavior of monoclonal antibody solutions
    Sandeep Yadav
    Late Stage Pharmaceutical Development, Genentech, Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Mol Pharm 9:791-802. 2012
    ..electrostatic surface potential distribution of monoclonal antibodies (MAbs) on intermolecular interactions and viscosity. Electrostatic models suggest MAb-1 has a less uniform surface charge distribution than MAb-2...
  81. pmc Protein folding: adding a nucleus to guide helix docking reduces landscape roughness
    Beth G Wensley
    Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK
    J Mol Biol 423:273-83. 2012
    ..We suggest that, by providing access to an alternative, faster, folding route over their landscape, R16 and R17 can circumvent their slow, frustrated wild-type folding mechanism...
  82. ncbi Transient binding and dissipation in cross-linked actin networks
    O Lieleg
    Lehrstuhl für Biophysik E27, Technische Universitat Munchen, Germany
    Phys Rev Lett 101:108101. 2008 experimentally tuning the off rate of the transiently cross-linking molecules, their density, and the solvent viscosity. We reproduce the measured frequency response by a semiphenomenological model that is predicated on microscopic ..
  83. ncbi The role of the cytoskeleton in the viscoelastic properties of human articular chondrocytes
    Wendy R Trickey
    Departments of Surgery and Biomedical Engineering, Orthopaedic Research Laboratories, Duke University Medical Center, 375 Medical Sciences Research Bldg, P O Box 3093, Durham, NC 27710, USA
    J Orthop Res 22:131-9. 2004
    ..With increasing cytochalasin D treatment, chondrocyte stiffness decreased by up to 90% and apparent viscosity decreased by up to 80%...
  84. ncbi An anisotropic-viscoplastic model of plant cell morphogenesis by tip growth
    Jacques Dumais
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    Int J Dev Biol 50:209-22. 2006
    ..Finally, we show that the mechanical anisotropy built into the model is required to account for observed patterns of wall expansion in plant cells...
  85. ncbi Sperm motility: is viscosity fundamental to progress?
    Jackson C Kirkman-Brown
    The Centre for Human Reproductive Science, Birmingham Women s Hospital, Edgbaston, Birmingham, UK
    Mol Hum Reprod 17:539-44. 2011
    ..What most research has neglected to consider is the role that the viscosity of the mucous layers, which coat the entire tract and through which sperm must swim, plays in both sperm ..
  86. pmc Substrate viscosity enhances correlation in epithelial sheet movement
    Michael Murrell
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Biophys J 101:297-306. 2011
    ..To better mimic physiological substrates that have inherent viscosity, we probe this relationship using polydimethylsiloxane, a substrate whose mechanical properties can be tuned ..
  87. ncbi Assessment of in vivo and post-mortem mechanical behavior of brain tissue using magnetic resonance elastography
    Jonathan Vappou
    Institut de mécanique des fluides et des solides UMR 7507 CNRS ULP, Strasbourg, France
    J Biomech 41:2954-9. 2008
    ..02). These results illustrate the ability of MRE to investigate some of the critical soft tissue biomechanics-related issues, as it can be used as a non-invasive tool for measuring soft tissue viscoelastic properties...
  88. ncbi Viscoelasticity-based MR elastography of skeletal muscle
    Dieter Klatt
    Department of Radiology, Charite Universitatsmedizin, Berlin, Germany
    Phys Med Biol 55:6445-59. 2010
    ..253 ± 0.009) to contraction (α = 0.270 ± 0.009). These results provide a reference for a future assessment of muscular dysfunction using rheological parameters...
  89. ncbi Ester hydroxy derivatives of methyl oleate: tribological, oxidation and low temperature properties
    Brajendra K Sharma
    USDA NCAUR ARS, Food and Industrial Oil Research, 1815 North University Street, Peoria, IL 61604, USA
    Bioresour Technol 99:7333-40. 2008
    ..Overall, the data indicate that some of these derivatives have significant potential as a lubricating oil or fuel additives...
  90. ncbi Analysis of viscoelastic wall properties in ovine arteries
    Daniela Valdez-Jasso
    Department of Mathematics, North Carolina State University, Raleigh, NC 27695 USA
    IEEE Trans Biomed Eng 56:210-9. 2009
    ..We also show that for all locations, the inclusion of viscoelastic behavior is important to capture pressure-area dynamics...
  91. pmc Fluctuations of the red blood cell membrane: relation to mechanical properties and lack of ATP dependence
    James Evans
    King s College London, Randall Division of Cell and Molecular Biophysics, Guy s Campus, London, United Kingdom
    Biophys J 94:4134-44. 2008
    ..This was caused by a rise in internal viscosity, as shown by measurements on resealed ghosts containing a reduced hemoglobin concentration, which displayed no ..
  92. ncbi Laser assisted bioprinting of engineered tissue with high cell density and microscale organization
    Bertrand Guillotin
    Universite Victor Segalen Bordeaux 2, Bordeaux Cedex, France
    Biomaterials 31:7250-6. 2010
    ..We have studied the effect of the viscosity of the bioink, laser energy, and laser printing speed on the resolution of cell printing...
  93. pmc Critical evaluation of Nanoparticle Tracking Analysis (NTA) by NanoSight for the measurement of nanoparticles and protein aggregates
    Vasco Filipe
    Division of Drug Delivery Technology, Leiden Amsterdam Center for Drug Research, Leiden University, P O Box 9502, 2300, RA, Leiden, The Netherlands
    Pharm Res 27:796-810. 2010
    ..To evaluate the nanoparticle tracking analysis (NTA) technique, compare it with dynamic light scattering (DLS) and test its performance in characterizing drug delivery nanoparticles and protein aggregates...
  94. pmc A novel virulence gene in Klebsiella pneumoniae strains causing primary liver abscess and septic metastatic complications
    Chi Tai Fang
    Department of Internal Medicine, National Taiwan University Hospital, Taipei 100
    J Exp Med 199:697-705. 2004
    ..We conclude that magA fits molecular Koch's postulates as a virulence gene. Thus, this locus can be used as a marker for the rapid diagnosis and for tracing the source of this emerging infectious disease...
  95. ncbi Preliminary characterization of exopolysaccharides produced by a marine biofilm-forming bacterium Pseudoalteromonas ruthenica (SBT 033)
    P Saravanan
    Department of Biotechnology, School of Life Sciences, Pondicherry University, Puducherry 605 014, India
    Lett Appl Microbiol 46:1-6. 2008
    ..The major objective of the present study was the partial characterization of the exopolysaccharides (EPS) produced by a marine biofilm-forming bacterium Pseudoalteromonas ruthenica under shake culture conditions...
  96. pmc Stepping, strain gating, and an unexpected force-velocity curve for multiple-motor-based transport
    Ambarish Kunwar
    Department of Developmental and Cell Biology, University of California, Irvine, California 92697, USA
    Curr Biol 18:1173-83. 2008
    ..Although we understand single motors experimentally and theoretically, our understanding of multiple motors working together is less developed...
  97. ncbi Computational modeling of ligament mechanics
    J A Weiss
    Department of Bioengineering, University of Utah, Salt Lake City 84112, USA
    Crit Rev Biomed Eng 29:303-71. 2001
    ..Applications of one-dimensional and three-dimensional constitutive models in the representation of the mechanical behavior of joints are presented. Future research directions are identified...
  98. pmc Ras diffusion is sensitive to plasma membrane viscosity
    J Shawn Goodwin
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Biophys J 89:1398-410. 2005
    ..GPI)-anchored and transmembrane proteins below the theoretical limit imposed by membrane viscosity. How the diffusion of proteins residing exclusively on the inner leaflet of the plasma membrane is regulated has ..
  99. pmc Reversible stress softening of actin networks
    Ovijit Chaudhuri
    UC San Francisco UC Berkeley Joint Graduate Group in Bioengineering and Department of Bioengineering, University of California at Berkeley, Berkeley, California 94720, USA
    Nature 445:295-8. 2007
    ..The observation of both stress stiffening and softening suggests a complex interplay between entropic and enthalpic elasticity in determining the mechanical properties of actin networks...
  100. pmc The influence of cement viscosity on the early migration of a tapered polished femoral stem
    S Glyn-Jones
    Oxford Orthopaedic Engineering Centre, Nuffield Orthopaedic Centre, Windmill Road, Headington, Oxford, OX3 7LD, UK
    Int Orthop 27:362-5. 2003
    It is unclear whether it is best to use high-viscosity or low-viscosity cement for fixation of total hip replacement (THR) femoral components...
  101. ncbi Viscosity and solute dependence of F-actin translocation by rabbit skeletal heavy meromyosin
    P B Chase
    Department of Radiology, University of Washington, Seattle 98195, USA
    Am J Physiol Cell Physiol 278:C1088-98. 2000
    We tested the hypothesis that solvent viscosity affects translocation of rhodamine phalloidin-labeled F-actin by rabbit skeletal heavy meromyosin (HMM). When viscosity was increased using either glycerol, fructose, sucrose, or dextran (1...

Research Grants68

  1. Lipid Droplet Metabolism
    Fredric B Kraemer; Fiscal Year: 2013
    ..This hypothesis will be tested using specialized equipment to measure the viscoelastic properties (viscosity, surface tension, etc...
    Marcos Intaglietta; Fiscal Year: 2011
    ..of functional capillary density in spite of its counterintuitive properties, including increased O2 affinity, viscosity and oncotic pressure...
  3. Fully Biodegradable Polymersome-encapsulated Hemoglobin as a Novel Nanoparticle-b
    ..characteristics of ideal oxygen therapeutic, such as tunable oxygen binding capacity, uniform and small size, viscosity and oncotic pressure characteristics similar to human blood as well as ease of mass production and storage...
  4. Bioengineering of Novel Synthetic Lipid-Peptide Lung Surfactants
    Robert H Notter; Fiscal Year: 2013
    ..Aim 4 studies the shear viscosity, pulmonary distribution, and cytotoxicity of instilled synthetic surfactants, as well as their utility in ..
    John F Engelhardt; Fiscal Year: 2013
    ..protecting the human lung from infection by secreting antibacterial factors and controlling the composition and viscosity of fluid in the airways...
  6. Muscle viscosity as a protective mechanism for absorbing mechanical shock
    Armen Sarvazyan; Fiscal Year: 2013 of external impacts to absorb mechanical shock is a fundamental function of skeletal muscle and the viscosity of the skeletal muscle is a variable parameter which can be voluntarily controlled by changing the tension of ..
  7. Cardiopulmonary structure and function in Multi-Ethnic Study of Atherosclerosis
    R Graham Barr; Fiscal Year: 2013
    ..2) Endothelium-dependent hypercoagulation, measured by PAI-1, and plasma viscosity is associated with greater TPVV, lower LV end-diastolic volume, greater emphysema and airflow obstruction...
  8. Recombinant Polymers for Transarterial Chemoembolization of Liver Cancer
    AZADEH POURSAID; Fiscal Year: 2013
    ..This provides the potential for ideal injectability as a low viscosity fluid at room temperature followed by optimal embolization by a highly stable hydrogel at body temperature...
  9. Measurement of Renal Viscoelastic Properties with Ultrasound
    MATTHEW WILLIAM URBAN; Fiscal Year: 2013
    ..imaging methods are emerging as a way to discriminate healthy versus diseased tissue based on the elasticity or viscosity of the tissue...
  10. Cell Free O2 Carriers: Cerebrovascular Control and Stroke
    RAYMOND CHARLES KOEHLER; Fiscal Year: 2013
    ..glycol (PEG-Hb) may be superior to previously tested polymerized Hb because of its higher oncotic pressure and viscosity, which promotes endothelial shear stress-induced NO production...
  11. Alkylammonium Formate Mobile Phase Modifiers for Protein Liquid Chromatography
    NEIL DANIELSON; Fiscal Year: 2009 ethyl-, n- propyl-, and n-butyl-ammonium formates have been synthesized and characterized with respect to viscosity, polarity, UV absorbance, and solvent strength for LC...
    Pamela L Zeitlin; Fiscal Year: 2012
    ..This dehydrates the airways and increases the viscosity of airways secretions, thereby impairing bacterial clearance...
  13. Real-time microviscosity measurement tools for the cell
    Mark A Haidekker; Fiscal Year: 2010
    ..Presently, viscosity on the microscopic scale is determined by fluorescence anisotropy, fluorescence recovery after photobleaching (..
  14. Functional Anatomic Imaging of CF Patients with Early Lung Disease Using microOCT
    Guillermo J Tearney; Fiscal Year: 2013
    ..ASL) and periciliary layer (PCL) depths, ciliary beating, and mucociliary transport while also measuring mucus viscosity by native particle tracking techniques...
  15. Myosin Functions in the Enterocyte
    Mark S Mooseker; Fiscal Year: 2012
    ..g. Ca2+ transport, lipid raft organization, BBM micro-viscosity, CFTR Cl- channel activity) when both Myo1a and Myo6 are absent...
  16. Exacerbation of pertussis airway inflammation and pathology by pertussis toxin
    Nicholas H Carbonetti; Fiscal Year: 2012
    ..Pendrin regulates airway surface liquid volume and mucus viscosity, and is implicated in airway pathology in mouse models of asthma and COPD, and therefore represents a potential ..
  17. Quantitative optical imaging of cilia-driven fluid flow
    MICHAEL ANDREW CHOMA; Fiscal Year: 2013
    ..assay can quantify biologically relevant perturbations to ciliary physiology including increased fluid viscosity and altered planar cell polarity...
  18. Exacerbation of pertussis airway inflammation and pathology by pertussis toxin
    Nicholas H Carbonetti; Fiscal Year: 2013
    ..Pendrin regulates airway surface liquid volume and mucus viscosity, and is implicated in airway pathology in mouse models of asthma and COPD, and therefore represents a potential ..
  19. Fo Motor Mechanisms that Power FoF1 ATP Synthesis
    Wayne D Frasch; Fiscal Year: 2013
    ..a previously unknown interaction between Fo subunits a and c of FoF1 when ATPase-driven rotation is slowed by a viscosity-induced load. A striking feature of this interaction is that it forms a tether that limits rotation to 360...
  20. High-performance Biocompatible GIC System with Permanent Antibacterial Function
    Dong Xie; Fiscal Year: 2010
    ..Flexural strength, wear- resistance and viscosity will be used as primary screening tools for cement formulation and optimization...
    ..Small amounts of cholesterol, when added to DPPC or to clinical lung surfactants, reduce the surface shear viscosity by orders of magnitude, without altering the minimum surface tension...
  22. Impact of Blood Viscosity on Oxygen Delivery in humans with Sickle Cell Anemia
    THOMAS DUANE COATES; Fiscal Year: 2011
    ..The pathophysiology of SCD is due in part to the increase in blood viscosity caused by hemoglobin S (HbS)...
  23. Effects of Bolus Accommodation on Swallowing Effort in Healthy Elderly Individual
    Lisa A Lagorio; Fiscal Year: 2011
    ..and describe changes in pressure and movement parameters, as a function of bolus accommodation (volume and viscosity) during swallowing...
  24. Chloride secretagogues for acquired CFTR dysfunction in chronic rhinosinusitis
    Bradford Alan Woodworth; Fiscal Year: 2013
    ..CFTR) deficiency may contribute to respiratory epithelial dysfunction by abrogating MCC and increasing mucus viscosity. The central hypothesis of the current proposal is that persistent mucosal inflammation and infection in chronic ..
  25. Study of the interplay of motility mechanisms during swaming of Myxococcus xanthu
    Mark Alber; Fiscal Year: 2013
    ..Specifically, we will study the role of flexibility of cells, viscosity of extracellular polysaccharide, slime adhesivity and directional reversals in resolving collisions, increasing ..
  26. Stability of Pullmonary Airways
    JAMES BERNARD GROTBERG; Fiscal Year: 2010
    ..fluid properties in disease (asthma, emphysema, cystic fibrosis) include viscoelasticity, shear-thinning viscosity, and a yield stress, all of which can alter the fluid movement...
  27. Tongue-pressure timing for liquid flow detection and control in swallowing
    ..Healthy young adults modulate tongue-pressure-timing across liquids of differing viscosity. We are requesting funding for the next phase in this research, to examine tongue-pressure timing in healthy ..
  28. Diffusion tensor MR spectroscopic imaging in human brain
    Stefan Posse; Fiscal Year: 2012
    ..Diffusion tensor 1H MRSI (DTSI) can provide unique information on intracellular properties, such as viscosity, cell swelling, restriction in subcellular structures and cytoplasmic streaming, that may help to characterize ..
  29. Community-Based, Phase III Trial of acupuncture to treat chronic Xerostomia
    Lorenzo Cohen; Fiscal Year: 2013
    ..Determine the effects of acupuncture on saliva based factors including pH, buffering capacity, and viscosity as well as levels of total protein, calcitonin- gene-related peptide (CGRP), and vasoactive intestinal ..
  30. Apparatus for encapsulating integral membrane proteins for structural studies by
    RONALD WILLIAM PETERSON; Fiscal Year: 2010
    ..within the protective aqueous core of a reverse micelle particle and the entire assembly is dissolved in a low viscosity fluid such as liquid ethane...
  31. Mucolytic for enhanced mucus and biofilm clearance in cystic fibrosis patients
    SHENDA BAKER; Fiscal Year: 2013
    ..Novel mucolytic therapies that innately reduce the viscosity of CF sputum, reduce the viability, cohesion and viscosity of pathogenic biofilms and improve mucociliary ..
  32. Disease States of Red Blood Cells in Vascular Microvessels
    ..In particular we will study the effects of (i) paraproteinemia which increases the plasma viscosity, and (ii) changes in the properties of the erythrocyte's membrane which occur due to malaria...
  33. Polymer-Surfactant Therapy in Rat Models of ARDS
    HWILLIAM TAEUSCH; Fiscal Year: 2010
    ..b>Viscosity and surface activity, with and without addition of common surfactant inhibitors, will be examined...
  34. In-situ Gelling Protein Polymer Intravascular Embolic Agent for Hepatic Carcinoma
    Hamid Ghandehari; Fiscal Year: 2012
    ..formulations;(2) to determine the gelation rate and gel strength of SELP fluids at their maximum injectable viscosity;(3) to assess their occlusion of simulated arterial channels in-vitro using a microfluidic device;and (4) ..
  35. Sensitivity enhancement in solution NMR through dynamic nuclear polarization
    A Joshua Wand; Fiscal Year: 2013
    ..Here we will take advantage of the physical properties of solutions of encapsulated proteins dissolved in low viscosity solvents of suitable dielectric character...
  36. Novel emulsion-based formulation of the anti-glaucoma MSH-1001 for improved topic
    Ronald A Wassel; Fiscal Year: 2011
    ..2) Take the three most promising emulsions that meet all of our criteria (i.e. the desired osmolality, pH, viscosity and droplet size) and test them in-vivo for ocular tolerance and histology in Dutch Belted rabbits...
  37. Efficient scouting instrumentation for the determination of reverse micelle encap
    RONALD WILLIAM PETERSON; Fiscal Year: 2012 within the protective aqueous core of a reverse micelle particle and dissolve the entire assembly in a low viscosity fluid such as liquid ethane...
  38. Dental Nanocomposite Materials Using Functional Polymer and HAP Nanocrystals
    Seung Wuk Lee; Fiscal Year: 2009
    ..The resulting composite structures will have a low viscosity and will be able to form and retain a desired shape at room temperature...
  39. Automated High Throughput Cryopreservation Using Microfluidics
    STEVEN FRANCIS MULLEN; Fiscal Year: 2010 rapidly mix combinations of solutions and to determine the appropriate flow rates for solutions of varying viscosity. We also plan to design a new microfluidics chip specifically for cryopreservation applications as well as a ..
  40. A novel approach to integral &anchored membrane protein structure &function
    A Joshua Wand; Fiscal Year: 2011
    ..within the protective aqueous core of a reverse micelle particle and the entire assembly is dissolved in a low viscosity fluid such as liquid ethane...
    KEERTAN UNKHA DHEDA; Fiscal Year: 2013
    ..and point mutations) and host factors (duration and severity of TB disease, cough strength and volume, sputum viscosity, HIV status, chest imaging characteristics) in those patients that are cough aerosol culture-positive versus ..
  42. Novel tungsten and bismuth nanoparticle contrast agents for MicroCT.
    Vishwas N Joshi; Fiscal Year: 2012
    ..The CIRs are attributed to the high viscosity and osmolality of the iodine agents...
  43. Predictive Modeling of collective swimming in bacterial supensions
    Leonid Berlyand; Fiscal Year: 2013
    ..suspensions of swimming bacteria: a dramatic increase in the effective diffusivity, a lowering of the effective viscosity by an order of magnitude, and the extraction of useful work from the correlated motion of bacteria...
  44. Quantization of Ocular Oxygen using a Modified Fluorotron
    James P Dillon; Fiscal Year: 2010
    ..In the process of these studies we will determine the viscosity of the lens, which is essential to determining the diffusion of oxygen and nutrients in that tissue...
  45. Virtual Biopsy with Ultrasound for Liver Fibrosis Staging
    Shigao Chen; Fiscal Year: 2013
    ..Ultrasound Dispersion Vibrometry (SDUV), for noninvasive, biopsy-like quantification of elasticity as well as viscosity for liver fibrosis staging...
  46. Classification of breast masses based on visco-elastic properties
    Michael F Insana; Fiscal Year: 2013
    ..This parameter is representative of tissue viscosity and elasticity...
  47. New optical approaches to study secretory granule structure and function
    Ronald W Holz; Fiscal Year: 2012
    ..goals in the proposal: 1) to understand the physical state of the granule lumen and reveal the role of lumenal viscosity in determining the rates of protein and catecholamine release, 2) to determine the translational mobility of ..
  48. Using deep-cavity cavitands to study supramolecular chemistry in water
    Bruce C Gibb; Fiscal Year: 2013 build the first thermodynamic models of the Hofmeister Effect at the molecular level, and has the potential to unify current models of the Hofmeister Effect based on bulk properties such as solubility, viscosity, and surface tension.
  49. Cerebellar function and rehabilitative strategies
    NASIR HUSAIN BHANPURI; Fiscal Year: 2012
    ..g. inertia, viscosity), of body parts and objects...
  50. Pathogen trapping by genital mucus secretions
    JUSTIN S HANES; Fiscal Year: 2013
    ..gonorrhoeae and C. trachomatis), and secretions that are rapidly penetrated. We will also determine the exact viscosity and elasticity experienced by each pathogen in the various human secretions...
  51. Effect of Physicochemical Properties of Ophthalmic Formulations on Ocular Bioavai
    Uday B Kompella; Fiscal Year: 2012
    ..We hypothesize that key physicochemical properties such as particle/globule size, size distribution, viscosity, pH, and zeta potential can influence drug release, residence time, and stability of the suspensions or ..
  52. Struct. Invest. of Hsp70 and TGFb by Solution Studies and High-Perform. Comput.
    EMRE H BROOKES; Fiscal Year: 2013
    ..such as the sedimentation coefficient, translational and rotational diffusion coefficients, and intrinsic viscosity, will be computed for each EC...
  53. Cytotoxic Heat Transfer and Thrombotic Risk in Microwave Tumor Ablation
    CHIH SHENG J CHIANG; Fiscal Year: 2013
    ..of this project will lead to better understanding of coupling electromagnetic analysis with thermal flow, blood viscosity changes in a high-temperature environment and endothelial damage near microwave ablation zones...
    WILLIAM SPIVAK; Fiscal Year: 1990
    ..previous viscometric studies to determine the effect of changes in bile pigment and calcium concentration on the viscosity of bile...
  55. Endoscopic Evaluation of Swallowing in Healthy Participants Across the Lifespan
    SUSAN GOODWIN BUTLER; Fiscal Year: 2011
    ..Specific aim one is to assess the effect of age, gender, bolus type, bolus volume, bolus viscosity, and bolus delivery method on swallowing in healthy participants...
  56. Impact of Seasonal Variation in Hematocrit, NOx & ET-1 on Vascular Reactivity
    Deidre Wipke Tevis; Fiscal Year: 2009
    ..Preliminary data in healthy men suggest that hematocrit (Hct, a determinant of blood viscosity) peaks while plasma nitrite/nitrate (NOx, a stable metabolite of the vasodilator molecule, nitric oxide) troughs ..
  57. Injectable, biocompatible poly (vinyl alcohol) hydrogels for tissue bulking
    Gavin Braithwaite; Fiscal Year: 2009
    ..investigation of the effects of concentration, molecular weight, and sterilization on the gelation kinetics and viscosity of a set of hydrogels...
    Robert Winslow; Fiscal Year: 2002
    ..the critical properties of cell-free hemoglobin responsible for this diffusive phenomenon, (ligand affinity, viscosity and colloid osmotic pressure) markedly influence the ability of cell-free hemoglobin to deliver O2 to tissue...
  59. Ultrasound As a Physical Force for Enhanced Scaffold-Based Bone Repair
    Yusuf M Khan; Fiscal Year: 2013
    ..collagen hydrogels of varying viscoelasticities to determine the relationship between applied force and hydrogel viscosity on cell behavior, and 3) to use acoustic force applied to hydrogels that have been loaded with cells and ..
  60. Apparatus for NMR spectroscopy of encapsulated proteins
    Ronald Peterson; Fiscal Year: 2009 achieved by encapsulating the protein in a reverse micelle system and dissolving the entire assembly in a low viscosity fluid such as liquid ethane...
    Marcos Intaglietta; Fiscal Year: 2004
    ..It is proposed that blood viscosity is a determinant of p02 distribution in the microcirculation because: 1) Viscosity is a factor in determining ..
    Marcos Intaglietta; Fiscal Year: 2009
    ..Conventional plasma expanders (PEs) lower blood viscosity and their use beyond the transfusion trigger causes: 1) Arteriolar vasoconstriction and decreased blood flow;2) ..
  63. Biomechanics of the False Vocal Folds
    Fariborz Alipour; Fiscal Year: 2013
    ..modes), acoustic characteristics (dependence on adduction, lengthening, A-P compression), aerodynamics (pressure, flow, flow resistance, PTP), and tissue characteristics (elastic modulus, viscosity, muscle architecture).
    David Long; Fiscal Year: 1980
    ..The RFC's are chemically stable and biologically inert and safe. Because of their low surface tension and low viscosity, fluorocarbon liquids coat surfaces readily and rapidly...
  65. Internal Polymeric Vessel Occluder for Temporary Vascular Occlusion of the Kidney
    PETER MADRAS; Fiscal Year: 2007
    ..At low temperatures, the polymeric solution is a liquid. As the temperature increases to body temperature, the viscosity of the solution rapidly increases several orders of magnitude to the consistency of a hard gel...
  66. Restitution of Lubrication in ACL Deficient Joints Preventing Wear
    Gregory Jay; Fiscal Year: 2009
    ..SZP) are the boundary lubricants of articular cartilage- a lubrication mechanism which arises in the absence of viscosity. Diarthrodial joint inflammation results in protease expression which easily catabolizes lubricin/SZP...
    TIMOTHY FISHER; Fiscal Year: 2003
    ..such as RBC aggregation, are minimized; the latter effect results in greatly reduced low-shear blood viscosity even when the hematocrit of SS blood is increased with coated RBC...
    Gregory Jay; Fiscal Year: 2003
    ..Most reports actually deal with the rheology of synovial fluid and may incorrectly assume that its viscosity is the basis for joint lubrication (5-10)...