photochemistry

Summary

Top Publications

  1. ncbi Photobleaching and photoactivation: following protein dynamics in living cells
    Jennifer Lippincott-Schwartz
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Cell Biol . 2003
  2. ncbi Adhesion and migration of ovarian cancer cells on crosslinked laminin fibers nanofabricated by multiphoton excited photochemistry
    Xiyi Chen
    Center for Cell Analysis and Modeling, Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Integr Biol (Camb) 1:469-76. 2009
  3. ncbi Reactive oxygen species in photochemistry of the red fluorescent protein "Killer Red"
    Russell B Vegh
    School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332 0400, USA
    Chem Commun (Camb) 47:4887-9. 2011
  4. ncbi Photochemistry of organic iron(III) complexing ligands in oceanic systems
    Katherine Barbeau
    Geosciences Research Division, Scripps Institution of Oceanography, University of California, San Diego, San Diego, CA, USA
    Photochem Photobiol 82:1505-16. 2006
  5. pmc Breaking the diffraction barrier in fluorescence microscopy at low light intensities by using reversibly photoswitchable proteins
    Michael Hofmann
    Department of NanoBiophotonics, Max Planck Institute for Biophysical Chemistry, D 37077 Gottingen, Germany
    Proc Natl Acad Sci U S A 102:17565-9. 2005
  6. ncbi Oxygen-dependent photochemistry and photophysics of "miniSOG," a protein-encased flavin
    Frederico M Pimenta
    Department of Chemistry, Center for Oxygen Microscopy and Imaging, Aarhus University, Aarhus, Denmark
    Photochem Photobiol 89:1116-26. 2013
  7. pmc In situ elasticity modulation with dynamic substrates to direct cell phenotype
    April M Kloxin
    Department of Chemical and Biological Engineering, University of Colorado, 424 UCB, ECCH 111, Boulder, CO 80309 USA
    Biomaterials 31:1-8. 2010
  8. ncbi Recent developments in photocatalytic water treatment technology: a review
    Meng Nan Chong
    School of Chemical Engineering, The University of Adelaide, 5005 Adelaide, Australia
    Water Res 44:2997-3027. 2010
  9. pmc Spatiotemporal control of cell signalling using a light-switchable protein interaction
    Anselm Levskaya
    The Cell Propulsion Lab, UCSF UCB NIH Nanomedicine Development Center, University of California, San Francisco, California 94158 2517, USA
    Nature 461:997-1001. 2009
  10. ncbi The bactericidal effect of TiO2 photocatalysis involves adsorption onto catalyst and the loss of membrane integrity
    Gaëtan Gogniat
    ENAC Laboratory for Environmental Biotechnology, Swiss Federal Institute of Technology EPFL, Lausanne, Switzerland
    FEMS Microbiol Lett 258:18-24. 2006

Detail Information

Publications373 found, 100 shown here

  1. ncbi Photobleaching and photoactivation: following protein dynamics in living cells
    Jennifer Lippincott-Schwartz
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Cell Biol . 2003
    ..Widespread applications of these fluorescent-based methods are revealing new aspects of protein dynamics and the biological processes that they regulate...
  2. ncbi Adhesion and migration of ovarian cancer cells on crosslinked laminin fibers nanofabricated by multiphoton excited photochemistry
    Xiyi Chen
    Center for Cell Analysis and Modeling, Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Integr Biol (Camb) 1:469-76. 2009
    ..To explore this possibility, we have used multiphoton excited photochemistry (MPE) to synthesize models of the ovarian basal lamina consisting of crosslinked laminin nanofibers to ..
  3. ncbi Reactive oxygen species in photochemistry of the red fluorescent protein "Killer Red"
    Russell B Vegh
    School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332 0400, USA
    Chem Commun (Camb) 47:4887-9. 2011
    ..We have investigated the source of the bioactive species through a variety of photophysical and photochemical techniques. Our results indicate a Type I (electron transfer mediated) photosensitizing mechanism...
  4. ncbi Photochemistry of organic iron(III) complexing ligands in oceanic systems
    Katherine Barbeau
    Geosciences Research Division, Scripps Institution of Oceanography, University of California, San Diego, San Diego, CA, USA
    Photochem Photobiol 82:1505-16. 2006
    ..This review highlights recent findings, including both model ligand studies and experimentallobservational studies of the natural seawater ligand pool...
  5. pmc Breaking the diffraction barrier in fluorescence microscopy at low light intensities by using reversibly photoswitchable proteins
    Michael Hofmann
    Department of NanoBiophotonics, Max Planck Institute for Biophysical Chemistry, D 37077 Gottingen, Germany
    Proc Natl Acad Sci U S A 102:17565-9. 2005
    ..Our results underscore the potential to finally achieve molecular resolution in fluorescence microscopy by technical optimization...
  6. ncbi Oxygen-dependent photochemistry and photophysics of "miniSOG," a protein-encased flavin
    Frederico M Pimenta
    Department of Chemistry, Center for Oxygen Microscopy and Imaging, Aarhus University, Aarhus, Denmark
    Photochem Photobiol 89:1116-26. 2013
    ....
  7. pmc In situ elasticity modulation with dynamic substrates to direct cell phenotype
    April M Kloxin
    Department of Chemical and Biological Engineering, University of Colorado, 424 UCB, ECCH 111, Boulder, CO 80309 USA
    Biomaterials 31:1-8. 2010
    ..These photodegradable hydrogels demonstrate the capability to both probe and direct cell function through dynamic changes in substrate elasticity...
  8. ncbi Recent developments in photocatalytic water treatment technology: a review
    Meng Nan Chong
    School of Chemical Engineering, The University of Adelaide, 5005 Adelaide, Australia
    Water Res 44:2997-3027. 2010
    ..This paper will deliver a scientific and technical overview and useful information to scientists and engineers who work in this field...
  9. pmc Spatiotemporal control of cell signalling using a light-switchable protein interaction
    Anselm Levskaya
    The Cell Propulsion Lab, UCSF UCB NIH Nanomedicine Development Center, University of California, San Francisco, California 94158 2517, USA
    Nature 461:997-1001. 2009
    ....
  10. ncbi The bactericidal effect of TiO2 photocatalysis involves adsorption onto catalyst and the loss of membrane integrity
    Gaëtan Gogniat
    ENAC Laboratory for Environmental Biotechnology, Swiss Federal Institute of Technology EPFL, Lausanne, Switzerland
    FEMS Microbiol Lett 258:18-24. 2006
    ..Our work suggests that adsorption of cells onto aggregated TiO2, followed by loss of membrane integrity, is key to the bactericidal effect of photocatalysis...
  11. ncbi The retinal pigment epithelium in visual function
    Olaf Strauss
    Bereich Experimentelle Ophthalmologie, Klinik und Poliklinik fuer Augenheilkunde, Universitaetsklinikum Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Physiol Rev 85:845-81. 2005
    ..On the other hand, mutations in genes expressed in photoreceptors can lead to degenerations of the RPE. Thus both tissues can be regarded as a functional unit where both interacting partners depend on each other...
  12. pmc Illuminating the chemistry of life: design, synthesis, and applications of "caged" and related photoresponsive compounds
    Hsien Ming Lee
    Department of Chemistry, The University of North Carolina, Chapel Hill, North Carolina 27599 3290, USA
    ACS Chem Biol 4:409-27. 2009
    ....
  13. ncbi Rational design of photoconvertible and biphotochromic fluorescent proteins for advanced microscopy applications
    Virgile Adam
    Laboratory of Photochemistry and Spectroscopy, Department of Chemistry, Katholieke Universiteit Leuven, 3001 Heverlee, Belgium
    Chem Biol 18:1241-51. 2011
    ..We present in particular NijiFP, a promising new fluorescent protein with photoconvertible and biphotochromic properties that make it ideal for advanced fluorescence-based imaging applications...
  14. ncbi Comparative photostability studies of BODIPY and fluorescein dyes by using fluorescence correlation spectroscopy
    Babette Hinkeldey
    Biophysical Chemistry, Saarland University, Campus B2 2, 66123 Saarbruecken, Germany
    Chemphyschem 9:2019-27. 2008
    ..Photobleaching is found to occur mainly through the first excited singlet state S(1), in contrast to previous findings...
  15. ncbi Bioinorganic photochemistry: frontiers and mechanisms
    Konrad Szaciłowski
    Faculty of Chemistry, Jagiellonian University, Krakow, Poland
    Chem Rev 105:2647-94. 2005
  16. ncbi Photoproduction of catalase-insensitive peroxides on the donor side of manganese-depleted photosystem II: evidence with a specific fluorescent probe
    Sergey A Khorobrykh
    Institute of Basic Biological Problems, Russian Academy of Sciences, Pushchino, Moscow Region 142290, Russia
    Biochemistry 50:10658-65. 2011
    ..These ROOH forms, likely including several species derived from lipid peroxides, may mediate the donor side-induced photoinhibition of PSII via protein modification...
  17. ncbi Carbocyanine dyes as efficient reversible single-molecule optical switch
    Mike Heilemann
    Applied Laserphysics and Laserspectroscopy, Physics Faculty, University of Bielefeld, Universitatsstrasse 25, 33615 Bielefeld, Germany
    J Am Chem Soc 127:3801-6. 2005
    ....
  18. ncbi Animal type 1 cryptochromes. Analysis of the redox state of the flavin cofactor by site-directed mutagenesis
    Nuri Ozturk
    Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 283:3256-63. 2008
    ....
  19. ncbi Singlet molecular oxygen generated from lipid hydroperoxides by the russell mechanism: studies using 18(O)-labeled linoleic acid hydroperoxide and monomol light emission measurements
    Sayuri Miyamoto
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, CP26077, CEP 05513 970, Brazil
    J Am Chem Soc 125:6172-9. 2003
    ....
  20. ncbi Engineering of a monomeric green-to-red photoactivatable fluorescent protein induced by blue light
    Nadya G Gurskaya
    Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho Maklaya 16 10, Moscow 117997, Russia
    Nat Biotechnol 24:461-5. 2006
    ..We demonstrate the suitability of Dendra for protein labeling and tracking to quantitatively study dynamics of fibrillarin and vimentin in mammalian cells...
  21. ncbi Photophysical and photosensitizing properties of selected cyanines
    Kawser Kassab
    National Institute of Laser Science, Cairo University, Cairo, Egypt
    J Photochem Photobiol B 68:15-22. 2002
    ....
  22. ncbi Initial characterization of the primary photochemistry of AppA, a blue-light-using flavin adenine dinucleotide-domain containing transcriptional antirepressor protein from Rhodobacter sphaeroides: a key role for reversible intramolecular proton transfer f
    Wouter Laan
    Laboratory for Microbiology, Swammerdam Institute for Life Sciences, BioCentrum Amsterdam, University of Amsterdam, The Netherlands
    Photochem Photobiol 78:290-7. 2003
    ..In this study, we provide further characterization of the primary photochemistry of this photoreceptor protein using UV-Vis and Fourier-transform infrared spectroscopy, pH measurements and ..
  23. pmc Structural characterization of IrisFP, an optical highlighter undergoing multiple photo-induced transformations
    Virgile Adam
    European Synchrotron Radiation Facility, 6 rue Jules Horowitz, BP 220, 38043 Grenoble Cedex, France
    Proc Natl Acad Sci U S A 105:18343-8. 2008
    ..The possibility to engineer and precisely control multiple phototransformations in photoactivatable FPs offers exciting perspectives for the extension of the fluorescent protein toolkit...
  24. ncbi Too much light? How beta-carotene protects the photosystem II reaction centre
    Alison Telfer
    Division of Molecular Biosciences, Imperial College London, South Kensington Campus, London, UK SW7 2AZ
    Photochem Photobiol Sci 4:950-6. 2005
    ..The relevance of a cycle of electrons around photosystem II, via cytochrome b(559), in order to re-reduce the beta-carotenes when they are oxidised and hence restore their ability to quench singlet oxygen, is also discussed...
  25. ncbi Factors affecting virus photoinactivation by a series of phenothiazine dyes
    S J Wagner
    American Red Cross Biomedical Services, Jerome H Holland Laboratory for the Biomedical Sciences, Rockville, MD 20855, USA
    Photochem Photobiol 67:343-9. 1998
    ....
  26. ncbi Functional recovery and expression of GDNF seen in photochemically induced cerebral infarction
    Keisuke Horinouchi
    Department of Rehabilitation and Physical Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, Sakuragaoka, Kagoshima, Japan
    Int J Neurosci 117:315-26. 2007
    ..Therefore, the expression of GDNF protein might have some relationship with the functional recovery of paralysis. There are great hopes that GDNF could be used as a therapeutic agent for cerebral infarction...
  27. ncbi Remote energy storage in Ni(OH)2 with TiO2 photocatalyst
    Yukina Takahashi
    Institute of Industrial Science, University of Tokyo, Komaba, Tokyo, 153 8505, Japan
    Phys Chem Chem Phys 8:2716-9. 2006
    ..It was revealed that the stored energy could be taken out and used chemically or electrochemically. The oxidized Ni(OH)2 was reduced by gaseous formaldehyde, formate, ethanol and H2O2...
  28. ncbi Photoelectric properties of a detector based on dried bacteriorhodopsin film
    Wei Wei Wang
    Department of Mechanical and Materials Engineering, Faculty of Engineering, The University of Western Ontario, London, Ontario, Canada N6A 5B9
    Biosens Bioelectron 21:1309-19. 2006
    ..Experimental observations and a predictive model both support the notion that dried bR film can be used in simple highly sensitive photo-detector designs...
  29. ncbi Making light work of enzyme catalysis: protochlorophyllide oxidoreductase
    Derren J Heyes
    Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, UK
    Trends Biochem Sci 30:642-9. 2005
    ..Recent advances in our understanding of the catalytic mechanism of POR illustrate why it is an important generic model for studying enzyme catalysis and reaction dynamics...
  30. ncbi Binding, aggregation and photochemical properties of methylene blue in mitochondrial suspensions
    Dino Gabrielli
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, Brazil
    Photochem Photobiol 79:227-32. 2004
    ..These differences in photochemical properties should influence the cytotoxic effects of photodynamic treatment in the presence of MB...
  31. ncbi Photochemical products in urban mixtures enhance inflammatory responses in lung cells
    Kenneth G Sexton
    Department of Environmental Science and Engineering, University of North Carolina at Chapel Hill, 27599, USA
    Inhal Toxicol 16:107-14. 2004
    ..In the absence of such particles, these gaseous products remained mostly as gases. These experiments show that photochemically produced gaseous products do influence the toxic responses of the cells in the absence of particles...
  32. ncbi Phytochrome-interacting factor 1 is a critical bHLH regulator of chlorophyll biosynthesis
    Enamul Huq
    Section of Molecular Cell and Developmental Biology and Institute of Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA
    Science 305:1937-41. 2004
    ....
  33. ncbi Photoactivation of the photoactive yellow protein: why photon absorption triggers a trans-to-cis Isomerization of the chromophore in the protein
    Gerrit Groenhof
    Department of Biophysical Chemistry, University of Groningen, Nijenborg 4, 9747 AG Groningen, The Netherlands
    J Am Chem Soc 126:4228-33. 2004
    ..It is this proton transfer that initiates the conformational changes within the protein, which are believed to lead to signaling...
  34. ncbi Photoswitchable fluorescent proteins enable monochromatic multilabel imaging and dual color fluorescence nanoscopy
    Martin Andresen
    Department of NanoBiophotonics, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Gottingen, Germany
    Nat Biotechnol 26:1035-40. 2008
    ..Furthermore, we demonstrate dual-color fluorescence microscopy with sub-diffraction resolution using bsDronpa and Dronpa whose emission maxima are separated by <20 nm...
  35. ncbi Photochemistry, remotely sensed physiological reflectance index and de-epoxidation state of the xanthophyll cycle in Quercus coccifera under intense drought
    José Javier Peguero-Pina
    Unidad de Recursos Forestales, Centro de Investigación y Tecnología Agroalimentaria, Gobierno de Aragón, Apdo 727, 50080 Saragossa, Spain
    Oecologia 156:1-11. 2008
    ..It is concluded that, contrary to early reports, PRI is a sensible, indirect, non-destructive water stress indicator, even in plants experiencing intense drought...
  36. pmc Enzymology below 200 K: the kinetics and thermodynamics of the photochemistry catalyzed by protochlorophyllide oxidoreductase
    Derren J Heyes
    Robert Hill Institute for Photosynthesis and Krebs Institute for Biomolecular Research, Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, United Kingdom
    Proc Natl Acad Sci U S A 99:11145-50. 2002
    ....
  37. pmc Caged compounds: photorelease technology for control of cellular chemistry and physiology
    Graham C R Ellis-Davies
    Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, USA
    Nat Methods 4:619-28. 2007
    ..Here I describe important examples of widely used caged compounds, their design features and synthesis, as well as practical details of how to use them with living cells...
  38. ncbi A new route for the prebiotic synthesis of nucleobases and hydantoins in water/ice solutions involving the photochemistry of acetylene
    César Menor-Salván
    Centro de Astrobiologia CSIC INTA, Ctra Torrejón Ajalvir km 4, 28850 Torrejon de Ardoz, Spain
    Chemistry 19:6488-97. 2013
    ..A mechanism for the origin of hydantoins and uracil from urea in plausible conditions for prebiotic chemistry is also proposed...
  39. pmc Whole-cell response of the pennate diatom Phaeodactylum tricornutum to iron starvation
    Andrew E Allen
    Centre National de la Recherche Scientifique Unite Mixte de Recherche 8186, Dept of Biology, Ecole Normale Superieure, 46 rue d Ulm, 75005 Paris, France
    Proc Natl Acad Sci U S A 105:10438-43. 2008
    ..Iron limitation leads to the elevated expression of at least three gene clusters absent from the Thalassiosira pseudonana genome that encode for components of iron capture and uptake mechanisms...
  40. ncbi Characterization of photosynthetic pigment composition, photosystem II photochemistry and thermal energy dissipation during leaf senescence of wheat plants grown in the field
    C Lu
    Photosynthesis Research Centre, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, PR China
    J Exp Bot 52:1805-10. 2001
    Photosynthetic pigment composition and photosystem II (PSII) photochemistry were characterized during the flag leaf senescence of wheat plants grown in the field...
  41. pmc Thermodynamics, kinetics, and photochemistry of β-strand association and dissociation in a split-GFP system
    Keunbong Do
    Department of Chemistry, Stanford University, Stanford, California 94305 5080, United States
    J Am Chem Soc 133:18078-81. 2011
    ..This peptide-protein photodissociation is a very unusual phenomenon and can potentially be useful for introducing spatially and temporally well-defined perturbations to biological systems as a genetically encoded caged protein...
  42. pmc Mineral dust photochemistry induces nucleation events in the presence of SO2
    Yoan Dupart
    Universite de Lyon 1, Lyon, Institut de Recherches sur la Catalyse et l Environnement de Lyon, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5256, Villeurbanne F 69626, France
    Proc Natl Acad Sci U S A 109:20842-7. 2012
    ..Under low dust conditions, this process may lead to nucleation events in the atmosphere. The laboratory findings are supported by recent field observations near Beijing, China, and Lyon, France...
  43. ncbi Characterization of PSII photochemistry and thermostability in salt-treated Rumex leaves
    Hua Xin Chen
    Department of Plant Science, Shandong Agricultural University, Taian, Shandong, 271018, PR China
    J Plant Physiol 161:257-64. 2004
    ..and polyphasic fluorescence transients, to determine the effect of salt treatment and heat stress on PSII photochemistry in Rumex leaves...
  44. ncbi Aryl azide photochemistry in defined protein environments
    Josephine L Morris
    School of Chemistry, Cardiff University, Cardiff CF10 3AT United Kingdom
    Org Lett 15:728-31. 2013
    ..Following photolysis of mutant T4 lysozyme or green fluorescent proteins, EPR spectra showed, respectively, the presence of a triplet nitrene and an anilino radical...
  45. ncbi The petite purple photosynthetic powerpack
    Michael R Jones
    Department of Biochemistry, School of Medical Sciences, University of Bristol, University Walk, Bristol, UK
    Biochem Soc Trans 37:400-7. 2009
    ..This review provides a short overview of the structure and mechanism of the purple bacterial RC, focusing in the main on the most heavily studied complex from Rhodobacter sphaeroides...
  46. ncbi Binding and photochemistry of enantiomeric 2-(3-benzoylphenyl)propionic acid (ketoprofen) in the human serum albumin environment
    Sandra Monti
    Istituto per la Sintesi Organica e la Fotoreattivita ISOF, CNR, Via P Gobetti 101, 40129, Bologna, Italy
    Photochem Photobiol Sci 6:462-70. 2007
    ..7-0.9). Secondary transients were consistent with the occurrence of photodecarboxylation and/or photoreduction within the protein matrix...
  47. pmc Photochemistry and photocytotoxicity of alkaloids from Goldenseal (Hydrastis canadensis L.) 3: effect on human lens and retinal pigment epithelial cells
    Colin F Chignell
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, NC, USA
    Photochem Photobiol 83:938-43. 2007
    ..Our findings show that eyewashes and lotions derived from Goldenseal or containing berberine must be used with caution when the eyes are exposed to bright sunlight but that oral preparations are not likely to cause ocular phototoxicity...
  48. ncbi Photosynthetic characterization of Rubisco transplantomic lines reveals alterations on photochemistry and mesophyll conductance
    Jeroni Galmés
    Research Group on Plant Biology under Mediterranean Conditions, Universitat de les Illes Balears, Ctra de Valldemossa Km 7 5, 07122 Palma, Spain
    Photosynth Res 115:153-66. 2013
    ..the introduced changes have little or no impact on other processes affecting photosynthesis such as leaf photochemistry or leaf CO2 diffusion conductances...
  49. ncbi A view on phosphate ester photochemistry by time-resolved solid state NMR. Intramolecular redox reaction of caged ATP
    Alexey V Cherepanov
    Biophysical Organic Chemistry Solid State NMR group, Leiden Institute of Chemistry, Faculty of Mathematics and Natural Sciences, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands
    Phys Chem Chem Phys 10:6820-8. 2008
    ..Photoreaction of caged ATP in situ gives an opportunity to study structural kinetics and catalysis of ATP-dependent enzymes by NMR spectroscopy in rotating solids...
  50. ncbi The photochemistry of flutamide and its inclusion complex with beta-cyclodextrin. Dramatic effect of the microenvironment on the nature and on the efficiency of the photodegradation pathways
    S Sortino
    Dipartimento di Scienze Chimiche, Universita di Catania, Viale Andrea Doria, 8 I 95125 Catania, Italy
    Photochem Photobiol 73:6-13. 2001
    The photochemistry of the anticancer drug flutamide (FM), 2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide, in homogeneous media and in the beta-cyclodextrin (beta-CD) cavity has been investigated...
  51. ncbi The first catalytic step of the light-driven enzyme protochlorophyllide oxidoreductase proceeds via a charge transfer complex
    Derren J Heyes
    Robert Hill Institute for Photosynthesis and Krebs Institute for Biomolecular Research, Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, United Kingdom
    J Biol Chem 281:26847-53. 2006
    ..to fit the Stark data, providing clear evidence that charge transfer complexes are formed during the initial photochemistry. The temperature dependences of both A696 formation and NADPH oxidation are identical, and we propose that ..
  52. pmc Environmental carcinogenic polycyclic aromatic hydrocarbons: photochemistry and phototoxicity
    Hongtao Yu
    Department of Chemistry, Jackson State University, Jackson, MS 39217, USA
    J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 20:149-83. 2002
    ..Although many books and reviews on these subjects have been published, PAH photochemistry and phototoxicity have received much less attention...
  53. pmc Structural evolution of the chromophore in the primary stages of trans/cis isomerization in photoactive yellow protein
    Karsten Heyne
    Max Born Institut fur Nichtlineare Optik und Kurzzeitspektroskopie, Max Born Strasse 2A, D 12489 Berlin, Germany
    J Am Chem Soc 127:18100-6. 2005
    ....
  54. ncbi Prebiotic adenine revisited: eutectics and photochemistry
    Leslie E Orgel
    The Salk Institute for Biological Studies, San Diego, CA, USA
    Orig Life Evol Biosph 34:361-9. 2004
    ..It is further suggested that the reaction of cyanoacetylene with cyanate in eutectic solution to give cytosine might have proceeded in parallel with adenine synthesis...
  55. ncbi Psoralen and coumarin photochemistry in HSA complexes and DMPC vesicles
    L Chen
    Steacie Institute for Molecular Sciences, National Research Council Canada, Ottawa, ON, Canada
    Photochem Photobiol 82:31-7. 2006
    The photochemistry and photophysics of several psoralens and coumarins have been examined in human serum albumin (HSA) complexes and dimyristoylphosphatidylcholine (DMPC) vesicles...
  56. ncbi Excited state reactions in fluorescent proteins
    Stephen R Meech
    School of Chemistry, University of East Anglia, Norwich, UK NR1 2QN
    Chem Soc Rev 38:2922-34. 2009
    ..Finally the photophysics underlying the new generation of photochemically active fluorescent proteins are discussed (155 references)...
  57. ncbi Photosynthetic alterations of pea leaves infected systemically by pea enation mosaic virus: A coordinated decrease in efficiencies of CO(2) assimilation and photosystem II photochemistry
    Helena Kyseláková
    Centre of the Region Haná for Biotechnological and Agricultural Research, Department of Biophysics, Faculty of Science, Palacky University, Slechtitelu 11, Olomouc CZ 78371, Czech Republic
    Plant Physiol Biochem 49:1279-89. 2011
    ..was not induced by stomata closure and corresponded with a decrease in the efficiency of photosystem II photochemistry (Φ(PSII))...
  58. ncbi Quantum-dot-sensitized TiO2 inverse opals for photoelectrochemical hydrogen generation
    Chuanwei Cheng
    Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, 637371 Singapore, Singapore
    Small 8:37-42. 2012
    ..The photoelectrochemical performance shows high photocurrent density (4.84 mA cm(-2) at 0 V vs. Ag/AgCl) under simulated solar-light illumination...
  59. ncbi Photochemistry in photonic crystal fiber nanoreactors
    Jocelyn S Y Chen
    Max Planck Institut für die Physik des Lichts, Günther Scharowsky Strasse 1 Bau 24, 91058 Erlangen, Germany
    Chemistry 16:5607-12. 2010
    ..Furthermore, the enhanced sensitivity and optical pump intensity implied that even systems with very small quantum yields can be measured very quickly--in our experiments one thousand times faster than in a conventional cuvette...
  60. ncbi Photophysics and photochemistry of z-chlorprothixene in acetonitrile
    Luis E Piñero
    Department of Chemistry, University of Puerto Rico at Humacao, Humacao, Puerto Rico
    Photochem Photobiol 85:895-900. 2009
    ..These results indicate that the phototoxicity of zCPTX is somehow affected by the formation of CTX...
  61. ncbi Photodynamic therapy: update 2006. Part 1: Photochemistry and photobiology
    P G Calzavara-Pinton
    Department of Dermatology, Azienda Ospedaliera Spedali Civili and University of Brescia, Piazzale Spedali Civili 1, 25123 Brescia, Italy
    J Eur Acad Dermatol Venereol 21:293-302. 2007
    ..This paper provides an overview of the chemistry of the photosensitizers, the photobiology and photoimmunology of the photodynamic reaction as well as the photophysical characteristics of the light sources available for PDT...
  62. ncbi Synthesis and DNA interactions of a bis-phenothiazinium photosensitizer
    Beth Wilson
    Department of Chemistry, Georgia State University, P O Box 4098, Atlanta, GA 30302 4098, USA
    Org Biomol Chem 6:4026-35. 2008
    ..Finally, viscometric data indicated that CT DNA interacts with compound 3 and MB by a combination of groove binding and monofunctional intercalation, and with compound 3 by a third, bisintercalative binding mode...
  63. pmc Different inactivation behaviors of MS-2 phage and Escherichia coli in TiO2 photocatalytic disinfection
    Min Cho
    School of Chemical Engineering, College of Engineering, Seoul National University, Sillim dong, Gwanak Gu, Seoul 151 742, South Korea
    Appl Environ Microbiol 71:270-5. 2005
    ..coli is inactivated by both the free and the surface-bound hydroxyl radicals. E. coli might also be inactivated by other ROS, such as O(2).(-) and H(2)O(2), according to the present results...
  64. ncbi Virus inactivation by silver doped titanium dioxide nanoparticles for drinking water treatment
    Michael V Liga
    Department of Civil and Environmental Engineering, Rice University, Houston, TX 77005, USA
    Water Res 45:535-44. 2011
    ..The increased production of hydroxyl free radicals was found to be responsible for the enhanced viral inactivation...
  65. ncbi Photochemistry of norharmane in aqueous solution
    M Micaela Gonzalez
    CIHIDECAR CONICET, Departamento de Quimica Organica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellon 2, 3p, Ciudad Universitaria, 1428, Buenos Aires, Argentina
    Photochem Photobiol Sci 8:1139-49. 2009
    The photochemistry of norharmane (9H-pyrido[3,4-b]indole) in acidic (pH 5.0+/-0.1) and alkaline (pH 10.0+/-0.1) aqueous solutions was studied...
  66. ncbi Determination of two phototransformation products of bentazone using quadrupole time-of-flight mass spectrometry
    Manuela Peschka
    Europa University of Applied Sciences, Limburger Strasse 2, Idstein, Germany
    Anal Bioanal Chem 388:1227-34. 2007
    ..The required irradiation time was matrix dependent. 2-(Isopropylcarbamoyl)phenylsulfamic acid was detected in a drainage channel in the Ebro river delta (Catalonia, Spain)...
  67. ncbi Formation of radicals from singlet oxygen produced during photoinhibition of isolated light-harvesting proteins of photosystem II
    Sara Rinalducci
    Department of Environmental Sciences, University of Tuscia, Largo dell Universita, 01100 Viterbo, Italy
    Biochim Biophys Acta 1608:63-73. 2004
    ..Thus, monomerization of antennae as well as their incorporation into the PSII complex seem to represent physiologically protected forms. A comparison is made of the photoinhibition mechanisms of different photosynthetic systems...
  68. ncbi The photochemistry of fluorescent proteins: implications for their biological applications
    Harriet E Seward
    Department of Biochemistry, University of Leicester, Henry Wellcome Building, Lancaster Road, Leicester, UK LE1 9HN
    Chem Soc Rev 38:2842-51. 2009
    ..In this tutorial review, we discuss the photochemistry of this fascinating class of proteins and illustrate some of their advantages and drawbacks in a range of ..
  69. ncbi One- and two-photon excitation of beta-carbolines in aqueous solution: pH-dependent spectroscopy, photochemistry, and photophysics
    M Micaela Gonzalez
    CIHIDECAR CONICET, Departamento de Quimica Organica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, 1428 Buenos Aires, Argentina
    J Phys Chem A 113:6648-56. 2009
    ..In this work, a study of the aqueous solution-phase photochemistry, photophysics, and spectroscopy of three important betaCs [norharmane (nHo), harmane (Ho), and harmine (Ha)] ..
  70. pmc Site-specific solvation of the photoexcited protochlorophyllide a in methanol: formation of the hydrogen-bonded intermediate state induced by hydrogen-bond strengthening
    Guang Jiu Zhao
    State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, Liaoning, China
    Biophys J 94:38-46. 2008
    ....
  71. ncbi Surface photochemistry of pesticides: an approach using diffuse reflectance and chromatography techniques
    José P Da Silva
    Centro de Quimica Fisica Molecular, Instituto Superior Tecnico, 1049 001 Lisboa, Portugal
    Environ Sci Technol 38:2849-56. 2004
    The photochemistry of pesticides triadimenol and triadimefon was studied on cellulose and beta-cyclodextrin (beta-CD) in controlled and natural conditions, using diffuse reflectance techniques and chromatographic analysis...
  72. ncbi UV photochemistry of DNA in vitro and in Bacillus subtilis spores at earth-ambient and low atmospheric pressure: implications for spore survival on other planets or moons in the solar system
    Wayne L Nicholson
    Department of Veterinary Science and Microbiology, University of Arizona, Tucson, Arizona 85721, USA
    Astrobiology 2:417-25. 2002
    ..To date, however, spore survival and DNA photochemistry have been explored only at the extremes of Earth-normal atmospheric pressure (101...
  73. ncbi Nuclear quantum tunneling in the light-activated enzyme protochlorophyllide oxidoreductase
    Derren J Heyes
    Manchester Interdisciplinary Biocentre, Faculty of Life Sciences, University of Manchester, 131 Princess Street, Manchester M1 7DN, United Kingdom
    J Biol Chem 284:3762-7. 2009
    ..Consequently, we have established the first important link between photochemical and nuclear quantum tunneling reactions, linked to protein dynamics, in a biologically significant system...
  74. ncbi Protochlorophyllide a: A Comprehensive Photophysical Picture
    Benjamin Dietzek
    Institute for Physical Chemistry, University Jena, Lessingstrasse 10, 07743 Jena, Germany
    Chemphyschem 10:144-50. 2009
    The photochemistry of protochlorophyllide a, a precursor in the biosynthesis of chlorophyll and substrate of the light regulated enzyme protochlorophyllide oxidoreductase, is investigated by pump-probe spectroscopy...
  75. ncbi The role of reactive oxygen species in Staphylococcus aureus photoinactivation by methylene blue
    Sonia Sabbahi
    National Institute of Research of Rural Engineering Water and Forestry Tunis, rue Hédi Karray, B P 10, 2080, Ariana, Tunis, Tunisia
    Water Sci Technol 58:1047-54. 2008
    ..aureus were studied spectrophotometrically. This demonstrated that a metachromatic reaction took place between MB and S. aureus bacteria. Furthermore, S. aureus bacteria induced additional dimerization of MB...
  76. ncbi Environmental photochemistry of nitro-PAHs: direct observation of ultrafast intersystem crossing in 1-nitropyrene
    Carlos E Crespo-Hernandez
    Department of Chemistry, Center for Chemical Dynamics, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA
    J Phys Chem A 112:6313-9. 2008
    ..The small energy gap suggests a large spin-orbit coupling between the S1(pipi*) and T3(npi*) states, which explains the ultrafast intersystem crossing of 1-nitropyrene in nonpolar solvents...
  77. pmc Characterization and photochemistry of 13-desmethyl bacteriorhodopsin
    Nathan B Gillespie
    Department of Chemistry, University of Connecticut, 55 North Eagleville Road, Storrs, Connecticut 06269 3060, USA
    J Phys Chem B 109:16142-52. 2005
    The photochemistry of the 13-desmethyl (DM) analogue of bacteriorhodopsin (BR) is examined by using spectroscopy, molecular orbital theory, and chromophore extraction followed by conformational analysis...
  78. ncbi Vibrioferrin, an unusual marine siderophore: iron binding, photochemistry, and biological implications
    Shady A Amin
    Department of Chemistry and Biochemistry, San Diego State University, San Diego, California 92182 1030, USA
    Inorg Chem 48:11451-8. 2009
    ..The consequences that these features have on bacterial-algal interactions with potential importance to understanding the origin and sustenance of harmful algal blooms are discussed...
  79. ncbi Electric field quenching of carbon nanotube photoluminescence
    Anton V Naumov
    Applied Physics Program, Rice University, Houston, Texas 77005, USA
    Nano Lett 8:1527-31. 2008
    ..Photoluminescence intensity was found to follow a reciprocal hyperbolic cosine dependence on electric field...
  80. doi Photocontrol of single-chain DNA conformation in cell-mimicking microcompartments
    Matthieu Sollogoub
    Institut de Chimie Moléculaire FR2769, Laboratoire de Chimie Organique UMR CNRS 7611, UPMC Universite Paris 06, 75005 Paris, France
    Chembiochem 9:1201-6. 2008
  81. ncbi Effect of light on self-assembly of aqueous mixtures of sodium dodecyl sulfate and a cationic, bolaform surfactant containing azobenzene
    F Pierce Hubbard
    Department of Chemical and Biological Engineering, University of Madison Wisconsin, 1415 Engineering Drive, Madison, Wisconsin 53706 1691, USA
    Langmuir 23:4819-29. 2007
    ..g., vesicles rich in trans-BTHA and SDS coexist with micelles rich in cis-BTHA and SDS). The results presented in this paper provide guidance for the design of light-tunable surfactants systems...
  82. ncbi Surface photochemistry: organic molecules within nanocavities of calixarenes
    Luis F Vieira Ferreira
    Centro de Química Física Molecular Complexo I, Inst Sup Téc, Universidade Tecnica de Lisboa, Av Rovisco Pais 1049 001 Lisboa, Portugal
    Curr Drug Discov Technol 4:229-45. 2007
    ..One of the main conclusions was that the solid support can deeply affect or even control the photochemistry of an adsorbed probe...
  83. ncbi Prebiotic significance of extraterrestrial ice photochemistry: detection of hydantoin in organic residues
    Pierre de Marcellus
    Universite Paris Sud, Astrochimie et Origines, Institut d Astrophysique Spatiale, Orsay, France
    Astrobiology 11:847-54. 2011
    ..result, together with other related experiments reported recently, points to the potential importance of the photochemistry of interstellar "dirty" ices in the formation of organics in Solar System materials...
  84. ncbi Morphological changes in vesicles and release of an encapsulated compound triggered by a photoresponsive Malachite Green leuconitrile derivative
    Ryoko M Uda
    Department of Chemical Engineering, Nara National College of Technology, Yata 22, Yamato koriyama, Nara 639 1080, Japan
    Langmuir 26:5444-50. 2010
    ..Furthermore, irradiation of the Malachite Green derivative induces the release of a vesicle-encapsulated compound...
  85. pmc Comparative photochemistry of animal type 1 and type 4 cryptochromes
    Nuri Ozturk
    Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    Biochemistry 48:8585-93. 2009
    ..Although the photochemistry of plant CRYs has been studied in some detail, the photochemical behavior of animal cryptochromes remains ..
  86. pmc EosFP, a fluorescent marker protein with UV-inducible green-to-red fluorescence conversion
    Jörg Wiedenmann
    Department of General Zoology and Endocrinology, University of Ulm, 89069 Ulm, Germany
    Proc Natl Acad Sci U S A 101:15905-10. 2004
    ..The possibility to locally change the emission wavelength by focused UV light makes EosFP a superb marker for experiments aimed at tracking the movements of biomolecules within the living cell...
  87. ncbi Effect of denaturation on the photochemistry of pyrimidine bases in isolated DNA
    Thierry Douki
    Laboratoire Lesions des Acides Nucleiques, Service de Chimie Inorganique et Biologique UMR E 3 CEA UJF, CEA DSM Département de Recherche Fondamentale sur la Matière Condensée, CEA Grenoble, 38054 Grenoble Cedex 9, France
    J Photochem Photobiol B 82:45-52. 2006
    The influence of denaturation on DNA photochemistry was studied by quantifying the yield of formation of all possible bipyrimidine photolesions within isolated genomic DNA samples exposed to UVC radiation...
  88. ncbi Structure, dynamics, and energetics of the primary photochemistry of photosystem II of oxygenic photosynthesis
    Bruce A Diner
    CR and D, Experimental Station, E I du Pont de Nemours and Co, Wilmington, Delaware 19880 0173, USA
    Annu Rev Plant Biol 53:551-80. 2002
    ....
  89. ncbi Photochemistry on metal nanoparticles
    Kazuo Watanabe
    Fritz Haber Institut der Max Planck Gesellschaft Faradayweg 4 6, 14195 Berlin, Germany
    Chem Rev 106:4301-20. 2006
  90. ncbi The photochemistry of 8-bromo-2'-deoxyadenosine. A direct entry to cyclopurine lesions
    Liliana B Jimenez
    Departamento de Quimica Instituto de Tecnologia Quimica UPV CSIC, Universidad Politecnica de Valencia, Camino de Vera s n, E 46022, Valencia, Spain
    Photochem Photobiol Sci 3:1042-6. 2004
    ....
  91. ncbi The 1.7 A crystal structure of Dronpa: a photoswitchable green fluorescent protein
    Pascal G Wilmann
    The Protein Crystallography Unit, Monash University, Clayton, Victoria 3800, Australia
    J Mol Biol 364:213-24. 2006
    ....
  92. ncbi Identification and characterization of the product release steps within the catalytic cycle of protochlorophyllide oxidoreductase
    Derren J Heyes
    Robert Hill Institute for Photosynthesis, Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, United Kingdom
    Biochemistry 43:8265-71. 2004
    ..Following release of Chlide, the subsequent binding of Pchlide allows the next catalytic cycle to proceed...
  93. ncbi Ultrafast time-resolved transient absorption and resonance raman spectroscopy study of the photodeprotection and rearrangement reactions of p-hydroxyphenacyl caged phosphates
    Chensheng Ma
    Contribution from the Department of Chemistry, The University of Hong Kong, SAR, P R China
    J Am Chem Soc 128:2558-70. 2006
    ..J. Am. Chem. Soc. 2005, 127, 1463-1472) provide a real time overall mechanistic description for the photodeprotection and rearrangement reactions of pHP caged phosphate phototrigger compounds...
  94. ncbi Production of reactive oxygen species in chloride- and calcium-depleted photosystem II and their involvement in photoinhibition
    Andras Arato
    Institut fur Biologie II, Biochemie der Pflanzen, Universitat Freiburg, Schänzlestr 1, 79104 Freiburg, Germany
    Biochim Biophys Acta 1608:171-80. 2004
    ....
  95. ncbi Transient absorption and photovoltage study of' self-assembled bacteriorhodopsin/polycation multilayer films
    Tapio Jussila
    Institute of Materials Chemistry, Tampere University of Technology, PO Box 541, 33101, Tampere, Finland
    Biosens Bioelectron 17:509-15. 2002
    ..A simultaneous two-exponential decay in millisecond time domain was observed at red wavelengths. The source of the red-shifted absorption is suggested to be the C(610) intermediate of the cis photocycle of bR...
  96. ncbi Structural events in the photocycle of green fluorescent protein
    Jasper J van Thor
    Laboratory of Molecular Biophysics, University of Oxford, Rex Richards Building, South Parks Road, Oxford OX1 3QU, United Kingdom
    J Phys Chem B 109:16099-108. 2005
    ..Vibrational spectral markers at 1695 cm(-1) assigned to Gln 69, at 1631 cm(-1) belonging to a C=C mode, and at 1354 cm(-1) belonging to a phenolate vibration further indicated the I2 and I* states to be unrelaxed...
  97. ncbi Photochemistry of 5-S-cysteinyldopa
    C Costantini
    Department of Organic and Biological Chemistry, University of Naples, Italy
    Photochem Photobiol 60:33-7. 1994
    ..These results are of interest in relation to the high susceptibility of fair-complexioned individuals to actinic damage and skin cancer...
  98. ncbi Visible light inactivation of bacteria and fungi by modified titanium dioxide
    Dariusz Mitoraj
    Faculty of Chemistry, Jagiellonian University, ul Ingardena 3, 30 060 Krakow, Poland
    Photochem Photobiol Sci 6:642-8. 2007
    ..faecalis>>C. albicans approximately A. niger. This sequence results most probably from differences in cell wall or cell membrane structures in these microorganisms and is not related to the ability of catalase production...
  99. ncbi Photocatalytic degradation of E. coliform in water
    Darren Delai Sun
    Environmental Engineering Research Center, School of Civil and Environmental Engineering, Nanyang Technological University, 639798 Singapore
    Water Res 37:3452-62. 2003
    ....
  100. ncbi Photoconsumption of oxygen in photosystem II preparations under impairment of the water-oxidizing complex
    S A Khorobrykh
    Institute of Basic Biological Problems, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia
    Biochemistry (Mosc) 67:683-8. 2002
    ....
  101. ncbi The excited-state chemistry of protochlorophyllide a: a time-resolved fluorescence study
    Benjamin Dietzek
    Institut fur Physikalische Chemie, Bayerische Julius Maximilians Universität Würzburg, Am Hubland, 97074 Wurzburg, Germany
    Chemphyschem 7:1727-33. 2006
    ....

Research Grants64

  1. PHOTOSENSTIZATION MECHANISMS IN HYPOXIC MEDIA
    ROBERT REDMOND; Fiscal Year: 2003
    ..An understanding of subtle microenvironment effects on PS photophysics and photochemistry and development of strategies to reduce PDT- induced hypoxia or provide oxygen-independent phytotoxicity will ..
  2. Electron Transfer in Iron and Copper Proteins
    Jay R Winkler; Fiscal Year: 2013
    ..e., Fe-oxo Compounds I and II) are often invoked. Protein labeling and laser flash-quench photochemistry will be used to develop new insights into the reactive intermediates in heme-thiolate mono-oxygenases...
  3. Structural and Computational Studies of LOV domain proteins and Cryptochromes
    Karen S Conrad; Fiscal Year: 2013
    ..photosensors that exhibit conformational changes upon light-excitation, but vary in terms of their photochemistry and structure...
  4. DNA PHOTOLESION STRUCTURE-ACTIVITY RELATIONSHIPS
    JOHN STEPHEN ADOLFINO TAYLOR; Fiscal Year: 2013
    ..Furthermore, the photochemistry of telomeres is largely unknown, in spite of their importance in maintaining genome stability...
  5. Advanced Naturally Designed Channelrhodopsins for Photocontrol of Neural Activity
    JOHN LEE SPUDICH; Fiscal Year: 2010
    ..and chimera construction guided by our years of experience in microbial rhodopsin structure-function, photochemistry, and spectral tuning will be applied to further optimize the desired properties to the new channelrhodopsins...
  6. Targeted Photoactivable Nanocells: Image-based Drug Delivery and Dosimetry in GBM
    Brian W Pogue; Fiscal Year: 2013
    ..We use targeted photodynamic therapy (PDT), a photochemistry-based technology to effectively treat GBM...
  7. Ultrafast Spectroscopic Methods to Probe Photodamage and Unfolding in Biopolymers
    David W McCamant; Fiscal Year: 2012
    ..This will allow the numerous tools of time-resolved spectroscopy, which currently have applications limited to photochemistry, to unravel the dynamics of thermally driven secondary structural changes on the picosecond to nanosecond time-..
  8. Structure and Function of Circadian Clock Light Sensors
    Brian R Crane; Fiscal Year: 2013
    ..At the center of these studies is the question of how protein conformational change links cofactor photochemistry to the modulation of protein assembly...
  9. Molecular characterization of mouse melanopsin and second messenger pathway.
    Phyllis R Robinson; Fiscal Year: 2012
    ..This approach is designed to determine melanopsin's photochemistry, to elucidate the nature of the second messenger pathway activated by melanopsin, and to determine if there ..
  10. Light Activation of Enzyme Inhibition
    JEREMY KODANKO; Fiscal Year: 2013
    ..Aims are 1) to develop new, potent versions of caged cathepsin and caspase inhibitors, 2) to understand the photochemistry of caged protease inhibitors and tune the wavelength of release;3) to characterize the behavior of caged ..
  11. Synthesis, Characterization, and Testing of Red-Shifted Glutamate Photoswitches
    Michael A Kienzler; Fiscal Year: 2013
    ..The PTL Maleimide-Azobenzene-Glutamate (MAG) takes advantage of the remarkable photochemistry of azobenzene, changes its shape (between the cis and trans isomers) depending on the irradiation wavelength ..
  12. Photodegradation Reactions Mono and Dinitro PAHs
    Rafael Arce; Fiscal Year: 2011
    ..It is important to study the photochemistry in these two environments because their photodegradation can proceed by entirely different mechanisms ..
  13. Structure/Function of Microbial Sensory Rhodopsins
    JOHN LEE SPUDICH; Fiscal Year: 2012
    ..Our working hypothesis based on ASR photochemistry is that the pair regulates biosynthesis of the antenna pigments of photosynthesis...
  14. Molecular Response and Imaging-based Combination Strategies for Optimal PDT
    Tayyaba Hasan; Fiscal Year: 2013
    ..PDT is a photochemistry-based modality that is approved for the treatment of a number of cancer and non-cancer pathologies...
  15. Glioblastoma PDT Design: Nanoagent Uptake and Tumor Oxygenation based dosimetry
    Srivalleesha Mallidi; Fiscal Year: 2013
    ..She will obtain extensive training in the fields of nanotechnology, photochemistry, tumor biology and GBM PDT strategies. The committee comprises of Dr. T...
  16. Photo-assisted targeting of immunotherapy to the bladder
    DIMITRI SIMBERG; Fiscal Year: 2013
    ..As an additional step, photochemistry will be used in order to stably "glue" the particles to the bladder wall;photocrosslinking could prolong the ..
  17. Ovarian Cancer PDT: Multi-intracellular targeting and Image-guided dosimetry
    Tayyaba Hasan; Fiscal Year: 2013
    ..of targeted inhibitors, and deliver combination regimens with photodynamic therapy (PDT), an FDA-approved photochemistry-based treatment that has shown clinical promise for OvCa...
  18. Heterocellular 3D ovarian tumor arrays for imaging and mechanistic combinations
    Tayyaba Hasan; Fiscal Year: 2013
    ..delivery of targeted inhibitors, and deliver rational combination regimens with PDT, an FDA approved photochemistry-based treatment that has shown clinical promise for OvCa...
  19. Enhanced radiation therapy with nanoscale frequency modulators
    Ming Su; Fiscal Year: 2012
    ..context, this particular submission is the cornerstone to establish an entirely new research area, In-vivo Photochemistry, in which functional nanoparticles that are delivered at certain site inside the body will be used as ..
  20. Dynamics and Mechanism of DNA-Repair Photolyase and Circadian Cryptochrome
    Dongping Zhong; Fiscal Year: 2013
    ..Thus, the second objective (Aim 2) is to systematically investigate the redox state(s) and related photochemistry, determine the active state in vivo in plant and animal cryptochromes, and characterize subsequent ..
  21. PHOTOCHEMICAL REGULATION OF CALCIUM IN CELL PHYSIOLOGY
    GRAHAM ELLIS-DAVIES; Fiscal Year: 2013
    ..innovations into reality we take a multidisciplinary approach, combining synthetic organic chemistry and photochemistry, laser photophysics, and cellular physiology...
  22. Bilirubin and Photobilirubin: Metabolism & Exretion
    Antony McDonagh; Fiscal Year: 2005
    ..These aims will be achieved by studying the chemistry, photochemistry, and metabolism of BR and specially designed synthetic model compounds both in vitro and in vivo in animals ..
  23. PHOTOTUNABLE BIOMATERIALS TO ENGINEER COMPLEX 3D CELL MICROENVIRONMENTS
    ANDREA MARIE KASKO; Fiscal Year: 2011
    ..In the last decade, there has been considerable interest in using photochemistry to produce biomaterials because of the ability to form scaffolds in situ under physiological conditions, in ..
  24. BIOTECHNOLOGY RESOURCE DIGITAL ELECTRO-OPTICAL IMAGING
    Warren R Zipfel; Fiscal Year: 2010
    ..3) Venturesome biotechnology developments based on new technologies, including optical nanostructures, nonlinear photochemistry and correlation spectroscopy to address several crucial but refractory challenges of biomedical research.
  25. Investigating Health Effects From Exposure to Organic Carbon and Nickel Aerosol
    Richard E Peltier; Fiscal Year: 2010
    ..emissions aerosol, which include enhancements with fine particle nickel, and processed by varying degrees of photochemistry, will be used to address health outcomes associated with exposure to fine particle aerosol...
  26. Genomic Approaches to Neuronal Diversity and Plasticity
    Jingyue Ju; Fiscal Year: 2007
    ..The combined approach based on genomics, photochemistry, nanoscience and engineering, biochemistry, and neuroscience will be used to understand how neurons and ..
  27. ISOMERIC RETINOIDS, CAROTENOIDS, THEIR PROTEIN COMPLEXES
    Robert Liu; Fiscal Year: 2001
    ..Such knowledge is clearly important for prediction of photochemistry of polyenes, for synthetic applications and for a better understanding of the specific mode of reaction in ..
  28. Visibly Caged Bio-active Molecules and PDT
    Paul Jones; Fiscal Year: 2004
    ..To photoactivate thrombin and TPA, enzymes of ophthalmological relevance, using visible light. IV. To develop photochemistry capable of photoreleasing biologically active aldehydes and an in vitro demonstration of biological activity ..
  29. NEW SYNTHETIC APPLICATION OF BENZENE PHOTOCHEMISTRY
    Richard Johnson; Fiscal Year: 1990
    ..A second broad objective is asymmetric organic photochemistry. Asymmetric induction in meta cycloadditions to benzene will be studied, with specific application to known ..
  30. PHOTOCHEMISTRY OF ARYL HALIDES AND ITS APPLICATIONS
    NIEN CHUN YANG; Fiscal Year: 1993
    ..a ring-contraction to form a ketene intermediate. We propose to carry out a systematic investigation on the photochemistry of halophenols, 4-haloindoles, halotyrosines and 4-halotrytophans in order to achieve a mechanistic ..
  31. ULTRAFAST MULTIPHOTON LASER ACTIVATION SYSTEM
    WATT WEBB; Fiscal Year: 2001
    ..a select set of innovative biomedical and biotechnology research programs that are implemented by multiphoton photochemistry and photophysics...
  32. Cell Cholesterol Efflux and HDL Formation
    Christopher Fielding; Fiscal Year: 2005
    PROPOSED PROGRAM (Applicant?s abstract) This Program Project combines techniques from lipid photochemistry, biochemistry and molecular and cell biology to characterize the structure and properties of the complexes formed between free ..
  33. A STUDY OF DNA INTERCALATING AROMATIC AMINO AZIDES
    Matthew Platz; Fiscal Year: 1991
    We will study the photochemistry of polycyclic aromatic amino azides which bind to DNA by intercalation...
  34. PATHOGEN-PROTECTIVE COATINGS FOR MEDICAL FABRICS
    Melvin Swanson; Fiscal Year: 1993
    ..The proposed methods will use photochemistry for covalently coating nonwoven fabrics with both hydrophilic photopolymers and hydrophobic photoreagents such ..
  35. PHOTOCHEMISTRY OF HUMAN RETINAL LIPOFUSCIN
    ELIZABETH GAILLARD; Fiscal Year: 2002
    DESCRIPTION (Adapted from applicant's abstract): This application is a proposal to study the photophysics and photochemistry of a number of chromophores that are present in the organic soluble portion of human retinal lipofuscin...
  36. MOLECULAR ORGANIZATION OF A MEMBRANE PROTEIN COMPLEX
    Richard Sayre; Fiscal Year: 1990
    ..mutagenesis of residues which bind the electron donors and acceptors and which regulate PS II reaction center photochemistry. These investigators will determine whether complex membrane protein structures can be effectively dissected ..
  37. Crown ethers based photo take-apartable molecular hosts
    Andrei Kutateladze; Fiscal Year: 2001
    ..The complexation selectivity and photochemistry/photophysics of the novel molecular systems will be examined to evaluate the prospects of their application in ..
  38. LOW TEMPERATURE CHEMISTRY/KINETICS/PHOTOAFFINITY LABELS
    Matthew Platz; Fiscal Year: 1993
    During the current grant period have discovered that the photochemistry of simple aromatic aides are remarkably sensitive to temperature...
  39. MASS SPECTROMETER FOR ORGANIC STRUCTURE DETERMINATION
    James Jackson; Fiscal Year: 1991
    ..Chang); (3) Study of novel structures In photochemistry (Dr...
  40. TETRACYCLINE CUTANEOUS PHOTOTOXICITY
    Harry Morrison; Fiscal Year: 1992
    ..The objectives of the program include the complete delineation of (a) tetracycline's unimolecular photochemistry and (b) the covalent binding of tetracycline photoproducts to nucleic acids...
  41. COVALENT SURFACE COATING WITH ANTITHROMBOTIC AGENTS
    DAVID CLAPPER; Fiscal Year: 1992
    ..Phase II will use proprietary BSI photochemistry to immobilize four classes of antithrombotic agents (hirudin, heparin, fibrinolytic enzymes, and ..
  42. Photochemistry of Azide Based Cross-Linkers in Water
    Matthew Platz; Fiscal Year: 2009
    ..Most practitioners utilize a few commercially available azide reagents. It is generally believed that the photochemistry of these reagents in water is similar to that of simple phenyl azides in organic solvents...
  43. Latent Reactive Groups for Biomaterials
    PATRICK GUIRE; Fiscal Year: 2005
    ..to the point of rapid growth in commercial availability (PhotoLink coatings based on triplet carbonyl photochemistry)...
  44. HIGH-RESOLUTION HIGH-MASS, TANDEM MASS SPECTROMETER
    Jeanette McNeill; Fiscal Year: 1991
    ..and between host and guest molecules, energetics of fragmentations of biomolecular ions, and the fundamental photochemistry that is associated with the acdon of some anti-AIDS compounds...
  45. PORPHYRIN SYNTHETIC METHODS FOR BIOORGANIC APPLICATIONS
    JONATHAN LINDSEY; Fiscal Year: 2007
    ..water-solubilizing groups, structural features to prevent dehydrogenation and suppress oxidation, and tunable photochemistry via alteration of the centrally coordinated metal...
  46. ULTRAVIOLET LIGHT INDUCED PHENOMENA IN BIOMEMBRANES
    IRENE KOCHEVAR; Fiscal Year: 2006
    ..The proposed research is designed to provide fundamental understanding of the the primary photochemistry, with emphasis on the events occurring at the plasma membrane, on UVR induced new gene expression, apoptosis ..
  47. Conference Grant Proposal: 12th Congress of the International Photodynamic Assn
    David Kessel; Fiscal Year: 2009
    Photodynamic Therapy (PDT) is a photochemistry based approach to the treatment of disease and relies on the use of light to activate certain non-toxic chemicals called photosensitizers...
  48. A PROGRAMMABLE DNA ARRAY SYNTHESIZER
    Xiaochuan Zhou; Fiscal Year: 2001
    ..Two innovations will be implemented: novel solution photochemistry and a programmable, maskless photolithographic system...
  49. Partial Protein Unfolding as a Novel Signaling Mechanism
    WOUTER HOFF; Fiscal Year: 2005
    ..PYP exhibits rhodopsin-like photochemistry based on its p-coumaric acid (pCA) chromophore, and has been investigated by X-ray crystallography...
  50. Topologically Unique Scaffolds in Photoassisted Diversity Oriented Synthesis (PDO
    Andrei G Kutateladze; Fiscal Year: 2010
    ..b>Photochemistry offers a range of spectacular skeletal transformations, yet their utilization in high throughput synthetic ..
  51. Vinylogous Amide Photochemistry in Organic Synthesis
    Jeffrey Winkler; Fiscal Year: 2005
    ..abstract_text> ..
  52. MODIFIED NAD+ FOR PHOTOAFFINITY LABELLING EXPERIMENTS
    Yuzhuo Li; Fiscal Year: 1993
    ..interest of the principal investigator is in the area of physical organic chemistry, with emphasis on the photochemistry of biologically active molecules...
  53. SURFACE-MODIFICATION OF BIOMATERIALS
    Peter Duquette; Fiscal Year: 1990
    ..b>Photochemistry is chosen, since this chemistry allows generic coupling to a wide range of medial device polymers...
  54. PHOTOCHEMISTRY OF GILVOCARCIN DERIVATIVES
    ANTONIO ALEGRIA; Fiscal Year: 1992
    ..One undergraduate student will participate in this research project to encourage him/her to proceed in graduate studies in a biomedical related area. ..
  55. BIOORGANIC PHOTOCHEMISTRY
    Michael Pirrung; Fiscal Year: 2000
    ..Novel patterned protein and cell immobilization methods will be investigated involving caged aldehydes (via our previously-developed dimethoxybenzoylformate (DMBF) group). A caged chemotactic peptide will be prepared. ..
  56. Integration at the Tripartite Synapse
    Philip Haydon; Fiscal Year: 2007
    ..and photolysis will be critical for many of the studies performed in this Conte Center we will include a photochemistry core (Ellis-Davies) within the center that will provide and develop new caged compounds for photo-release by ..
  57. PHOTODYNAMICS OF ULTRAVIOLET EPIDERMAL CHROMOPHORES
    John Simon; Fiscal Year: 2002
    ..spectra for its various photochemical processes, (c) to develop a comprehensive model for the spectroscopy and photochemistry of synthetic and natural melanins, and (d) to study how drug molecules bound to melanin affect the ..
  58. PHOTOCHEMISTRY OF DIAZENIUMDIOLATES--NO RELEASING DRUGS
    JOHN TOSCANO; Fiscal Year: 2002
    ..In addition, if diazeniumdiolates are to enjoy routine medical use, their basic photochemistry must be understood so that phototoxicity issues may be anticipated and avoided The specific aims of the ..
  59. Core Resources for Vision Research at MUSC
    Craig Crosson; Fiscal Year: 2007
    ..Projects benefiting from this infrastructure activity include research on retinoid photochemistry, biology of phototransduction, retinal degeneration, glaucoma, retinal neovascularization, structure-function ..
  60. PHOSPHATE-DERIVED PHOTOAFFINITY LABELS
    Paul Bartlett; Fiscal Year: 1980
    ..the investigation of photolabels for aspartate transcarbamylase and membrane-bound proteins, a study of the photochemistry of the alpha-diazophosphonic acid derivatives, and the synthesis of some diazo analogs of pyrophosphate esters.
  61. PROGRAMMABLE DNA/RNA ARRAY SYNTHESIZER
    Xiaochuan Zhou; Fiscal Year: 1999
    ..Two innovations will be implemented: A novel solution photochemistry allows well established conventional synthesis protocols to be used in DNA/RNA synthesis with light-directed ..
  62. 500MHz Console Upgrade
    Bruce Ganem; Fiscal Year: 2003
    ..R. Crane aims to understand how protein structure controls redox- and photochemistry in biological catalysis and signal transduction. Professor G.W...
  63. ULTRAVIOLET IRRADIATION OF NATURAL PRODUCTS
    WILLIAM DAUBEN; Fiscal Year: 1993
    ..Such studies will help to define the nature of the active site of the vitamin. A study of the photochemistry and photophysics in the whole vitamin D cascade will be studied in detail using narrow band light from tunable ..
  64. DEVELOPMENT OF AN IMPROVED INVITRO METASTATIC ASSAY
    DAVID CLAPPER; Fiscal Year: 1993
    ..During Phase I, patented BSI photochemistry will be used to covalently couple type IV collagen and heparin onto the polycarbonate membranes with the ..