Toxic potential of materials at the nanolevelAndre Nel
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
Science 311:622-7. 2006
..The establishment of principles and test procedures to ensure safe manufacture and use of nanomaterials in the marketplace is urgently required and achievable...
Understanding biophysicochemical interactions at the nano-bio interfaceAndre E Nel
Division of NanoMedicine, David Geffen School of Medicine and California NanoSystems Institute at UCLA, Los Angeles, California 90095, USA
Nat Mater 8:543-57. 2009
..This knowledge is important from the perspective of safe use of nanomaterials...
- Size-dependent cytotoxicity of gold nanoparticles
Yu Pan
Biomedical Engineering, Biointerface Laboratory, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany
Small 3:1941-9. 2007
..The cellular response is size dependent, in that 1.4-nm particles cause predominantly rapid cell death by necrosis within 12 h while closely related particles 1.2 nm in diameter effect predominantly programmed cell death by apoptosis...
- Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications
Ajay Kumar Gupta
Crusade Laboratories Limited, Southern General Hospital, 1345 Govan Road, Glasgow G51 4TF, Scotland, UK
Biomaterials 26:3995-4021. 2005
..that these nanoparticles have high magnetization values and size smaller than 100 nm with overall narrow particle size distribution, so that the particles have uniform physical and chemical properties...
- Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells
B Devika Chithrani
Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada
Nano Lett 6:662-8. 2006
..g., tuning intracellular delivery rates and amounts by nanoscale dimensions and engineering complex, multifunctional nanostructures for imaging and therapeutics)...
- Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology
Marie-Christine Daniel
Molecular Nanosciences and Catalysis Group, LCOO, UMR CNRS No. 5802, , 33405 Talence Cedex, France
Chem Rev 104:293-346. 2004
Factors affecting the clearance and biodistribution of polymeric nanoparticlesFrank Alexis
Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Mol Pharm 5:505-15. 2008
....
- Elucidating the mechanism of cellular uptake and removal of protein-coated gold nanoparticles of different sizes and shapes
B Devika Chithrani
Institute of Biomaterials and Biomedical Engineering, Terrence Donnelly Center for Cellular and Biomolecular Research, University of Toronto, 160 College Street, 4th Floor, Toronto, Ontario M5S 3G9, Canada
Nano Lett 7:1542-50. 2007
..These studies will provide guidelines for developing NPs for imaging and drug delivery applications, which will require "controlling" NP accumulation rate. These studies will also have implications in determining nanotoxicity...
- Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles
Chunbai He
State Key Laboratory of Genetic Engineering, Department of Pharmaceutical Sciences, School of Life Sciences, Fudan University, Shanghai 200433, China
Biomaterials 31:3657-66. 2010
To elucidate the effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles (NPs), rhodamine B (RhB) labeled carboxymethyl chitosan grafted NPs (RhB-CMCNP) and chitosan hydrochloride ..
- Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles
Gunter Oberdorster
Department of Environmental Medicine, University of Rochester, Rochester, New York 14642, USA
Environ Health Perspect 113:823-39. 2005
..An interdisciplinary team approach (e.g., toxicology, materials science, medicine, molecular biology, and bioinformatics, to name a few) is mandatory for nanotoxicology research to arrive at an appropriate risk assessment...
- Silver nanoparticles as a new generation of antimicrobials
Mahendra Rai
Department of Biotechnology, SGB Amravati University, Amravati 444 602, Maharashtra, India
Biotechnol Adv 27:76-83. 2009
..Hence, silver nanoparticles have emerged up with diverse medical applications ranging from silver based dressings, silver coated medicinal devices, such as nanogels, nanolotions, etc...
- Preparation and evaluation of self-microemulsifying drug delivery system of oridonin
Ping Zhang
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 210203, PR China
Int J Pharm 355:269-76. 2008
..The absorption of oridonin from SMEDDS showed a 2.2-fold increase in relative bioavailability compared with that of the suspension. Our studies demonstrated the promising use of SMEDDS for the delivery of oridonin by the oral route...
- Optimization and characterization of anionic lipoplexes for gene delivery
Charudharshini Srinivasan
Department of Pharmaceutical Sciences, University of Connecticut, 69 North Eagleville Road, Unit 3092, Storrs, CT 06269, USA
J Control Release 136:62-70. 2009
..8 microg plasmid DNA. Biophysical studies (particle size analysis, gel electrophoresis, transmission electron microscopy (TEM), and confocal microscopy) were conducted ..
- The kinetics of the tissue distribution of silver nanoparticles of different sizes
D P K Lankveld
Laboratory for Health Protection Research, National Institute for Public Health and the Environment RIVM, PO Box 1, 3720 BA Bilthoven, The Netherlands
Biomaterials 31:8350-61. 2010
..Model parameter values were estimated by fitting to data. No clear relation between parameter values and corresponding particle diameters became apparent...
- Biodistribution of colloidal gold nanoparticles after intravenous administration: effect of particle size
Ganeshchandra Sonavane
Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, Japan
Colloids Surf B Biointerfaces 66:274-80. 2008
..Another objective was to study effect of particle size on biological distribution of gold NP to enable their diverse applications in nanotechnology...
- Nanoparticle-mediated cellular response is size-dependent
Wen Jiang
Nat Nanotechnol 3:145-50. 2008
..The findings presented here may assist in the design of nanoscale delivery and therapeutic systems and provide insights into nanotoxicity...
- The effect of fine and coarse particulate air pollution on mortality: a national analysis
Antonella Zanobetti
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
Environ Health Perspect 117:898-903. 2009
..5) and PM coarse on the increased risk of death for all causes, cardiovascular disease (CVD), myocardial infarction (MI), stroke, and respiratory mortality for the years 1999-2005...
- Paclitaxel-loaded PEGylated PLGA-based nanoparticles: in vitro and in vivo evaluation
Fabienne Danhier
Universite Catholique de Louvain, Unite de Pharmacie Galenique, Avenue Mounier, 73 20, 1200 Brussels, Belgium
J Control Release 133:11-7. 2009
..Therefore, PTX-loaded nanoparticles may be considered as an effective anticancer drug delivery system for cancer chemotherapy...
- Circulating microparticles: pathophysiology and clinical implications
Andrea Piccin
Irish Blood Transfusion Service, James s Street, Dublin 8, Ireland
Blood Rev 21:157-71. 2007
..In addition the complex role of microparticles in vascular and cardiovascular diseases is an area of immense interest, that promises to yield important advances into diagnosis and therapy...
- Chronic fine and coarse particulate exposure, mortality, and coronary heart disease in the Nurses' Health Study
ROBIN C PUETT
South Carolina Cancer Prevention and Control Program and Department of Epidemiology, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina 29201, USA
Environ Health Perspect 117:1697-701. 2009
..5 and 10 microm (PM(10-2.5)), may also be important. With respect to mortality and cardiovascular events, questions remain regarding the relative strength of effect sizes for chronic exposure to fine and coarse particles...
- The use of hypromellose in oral drug delivery
Chi L Li
GlaxoSmithKline Pharmaceuticals, Pharmaceutical Development, New Frontiers Science Park South, Third Avenue, Harlow, Essex, CM19 5AW, UK
J Pharm Pharmacol 57:533-46. 2005
....
- PVP-coated silver nanoparticles and silver ions induce reactive oxygen species, apoptosis and necrosis in THP-1 monocytes
Rasmus Foldbjerg
Department of Environmental and Occupational Medicine, Institute of Public Health, Aarhus University, Bartholins Alle 2, Bygn 1260, 8000 Aarhus, Denmark
Toxicol Lett 190:156-62. 2009
..A drastic increase in ROS levels could be detected after 6-24h suggesting that oxidative stress is an important mediator of cytotoxicity caused by Ag NPs and Ag+...
- Ambient air pollution and low birth weight in Connecticut and Massachusetts
Michelle L Bell
School of Forestry and Environmental Studies, Yale University, New Haven, Connecticut 06511, USA
Environ Health Perspect 115:1118-24. 2007
..Several studies have examined whether air pollution affects birth weight; however results vary and many studies were focused on Southern California or were conducted outside of the United States...
- The impact of polycyclic aromatic hydrocarbons and fine particles on pregnancy outcome
J Dejmek
Laboratory of Genetic Ecotoxicology, Regional Institute of Hygiene of Central Bohemia and Institute of Experimental Medicine, Academy of Science of the Czech Republic, Prague, Czech Republic
Environ Health Perspect 108:1159-64. 2000
..The results prove that exposure to c-PAHs in early gestation may influence fetal growth. The particulate matter-IUGR association observed earlier may be at least partly explained by the presence of c-PAHs on particle surfaces...
- Human serum albumin nanoparticles as an efficient noscapine drug delivery system for potential use in breast cancer: preparation and in vitro analysis
Safaa Sebak
Biomedical Technology and Cell Therapy Research Laboratory, Department of Biomedical Engineering, Faculty of Medicine, McGill University, Montreal, Quebec, Canada
Int J Nanomedicine 5:525-32. 2010
..The nanoparticles were designed and optimized to achieve a particle size in the range of 150-300 nm with a drug-loading efficiency of 85%-96%...
- Woodsmoke health effects: a review
Luke P Naeher
Department of Environmental Health Science, College of Public Health, University of Georgia, Athens, Georgia, USA
Inhal Toxicol 19:67-106. 2007
..In addition, we provide recommendations for additional woodsmoke research...
- Fine particulate matter constituents associated with cardiovascular hospitalizations and mortality in New York City
Kazuhiko Ito
New York University School of Medicine, Tuxedo, New York 10987, USA
Environ Health Perspect 119:467-73. 2011
..We investigated this issue in New York City (NYC), where PM originates from regional and local combustion sources...
- Health effects of fine particulate air pollution: lines that connect
C Arden Pope
Department of Economics, Brigham Young University, Provo, UT 84602 2363, USA
J Air Waste Manag Assoc 56:709-42. 2006
....
- Translocation of inhaled ultrafine particles to the brain
G Oberdorster
Department of Environmental Medicine, University of Rochester, Rochester, New York 14642, USA
Inhal Toxicol 16:437-45. 2004
..Depending on their particle size, inhaled UFP are efficiently deposited in nasal, tracheobronchial, and alveolar regions due to diffusion...
- Copper oxide nanoparticles are highly toxic: a comparison between metal oxide nanoparticles and carbon nanotubes
Hanna L Karlsson
Department of Biosciences and Nutrition at Novum, Karolinska Institutet, Stockholm, Sweden
Chem Res Toxicol 21:1726-32. 2008
..The effects were not explained by soluble metal impurities. In conclusion, this study highlights the in vitro toxicity of CuO nanoparticles...
- Residual polyvinyl alcohol associated with poly (D,L-lactide-co-glycolide) nanoparticles affects their physical properties and cellular uptake
Sanjeeb K Sahoo
Department of Pharmaceutical Sciences, University of Nebraska Medical Center 986025, Omaha, NE 68198-6025, USA
J Control Release 82:105-14. 2002
..The residual PVA, in turn, influenced different pharmaceutical properties of nanoparticles such as particle size, zeta potential, polydispersity index, surface hydrophobicity, protein loading and also slightly influenced ..
- A review of the in vivo and in vitro toxicity of silver and gold particulates: particle attributes and biological mechanisms responsible for the observed toxicity
Helinor J Johnston
Centre for Nano Safety, School of Life Sciences, Edinburgh Napier University, Edinburgh, UK
Crit Rev Toxicol 40:328-46. 2010
..Alternatively, a combination of both may be responsible, as the release of ions would be expected to be greater for smaller particles...
- Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution
C Arden Pope
Department of Economics, Brigham Young University, 142 FOB, Provo, UT 84602, USA
JAMA 287:1132-41. 2002
..However, studies of health effects of long-term particulate air pollution have been less conclusive...
- Gold nanoparticles administration induced prominent inflammatory, central vein intima disruption, fatty change and Kupffer cells hyperplasia
Mohamed Anwar K Abdelhalim
Department of Physics and Astronomy, College of Science, King Saud University, Saudi Arabia
Lipids Health Dis 10:133. 2011
....
- A review of carbon nanotube toxicity and assessment of potential occupational and environmental health risks
Chiu wing Lam
JSC Toxicology Group, Space Life Sciences, NASA Johnson Space Center, Wyle Laboratories and Department of Pathology and Laboratory Medicine, University of Texas Medical School, Houston, Texas 77058, USA
Crit Rev Toxicol 36:189-217. 2006
..Therefore, CNTs from manufactured and combustion sources in the environment could have adverse effects on human health...
- Size-dependent proinflammatory effects of ultrafine polystyrene particles: a role for surface area and oxidative stress in the enhanced activity of ultrafines
D M Brown
School of Life Sciences, Napier University, 10 Colinton Road, Edinburgh EH10 5DT, Scotland
Toxicol Appl Pharmacol 175:191-9. 2001
..the effects of ultrafine particles in the lung have shown adverse effects considered to be due in part to the particle size. Air pollution particles (PM(10)) are associated with exacerbations of respiratory disease and deaths from ..
- Gastrointestinal persorption and tissue distribution of differently sized colloidal gold nanoparticles
J F Hillyer
Department of Animal Health and Biomedical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 1656 Linden Drive, Madison, Wisconsin 53706, USA
J Pharm Sci 90:1927-36. 2001
..In our quantitative studies we found that colloidal gold uptake is dependent on particle size: smaller particles cross the gastrointestinal tract more readily...
- Particle size-dependent organ distribution of gold nanoparticles after intravenous administration
Wim H De Jong
Laboratory for Health Protection Research, National Institute for Public Health and the Environment RIVM, Antonie van Leeuwenhoeklaan 9, Bilthoven, The Netherlands
Biomaterials 29:1912-9. 2008
A kinetic study was performed to determine the influence of particle size on the in vivo tissue distribution of spherical-shaped gold nanoparticles in the rat...
- Cytotoxicity and immunological response of gold and silver nanoparticles of different sizes
Hung Jen Yen
Department of Chemical Engineering, National Chung Hsing University, 250 Kuo Kuang Road, Taichung 402, Taiwan, R O C
Small 5:1553-61. 2009
....
- The impact of size on tissue distribution and elimination by single intravenous injection of silica nanoparticles
Minjung Cho
Division of Toxicologic Pathology, National Institute of Toxicological Research, Korea Food and Drug Administration, 231 Jinhongno Enpyung ku, Seoul 122 704, Republic of Korea
Toxicol Lett 189:177-83. 2009
..Silica nanoparticles were trapped by macrophages in the spleen and liver and remained there until 4 weeks after the single injection...
- Development of superparamagnetic nanoparticles for MRI: effect of particle size, charge and surface nature on biodistribution
C Chouly
Laboratoire de Biophysique, Faculte de Medecine, Angers, France
J Microencapsul 13:245-55. 1996
..It was up to 3 X lower for electrically neutral particles than for charged particles. Coated particles presented higher vascular persistence. The diagnostic potential for liver, lymph node or vascular imaging were discussed...
- Nanocarriers' entry into the cell: relevance to drug delivery
Hervé Hillaireau
School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA
Cell Mol Life Sci 66:2873-96. 2009
..Nevertheless, various strategies are being actively investigated in order to tailor nanocarriers able to deliver anticancer agents, nucleic acids, proteins and peptides for therapeutic applications by these non-phagocytic routes...
- Degradable polyethylenimine-alt-poly(ethylene glycol) copolymers as novel gene carriers
Mi Ran Park
School of Agricultural Biotechnology, Seoul National University, Seoul 151-742, Korea
J Control Release 105:367-80. 2005
....
- Preparation, characterization, and in vitro targeted delivery of folate-decorated paclitaxel-loaded bovine serum albumin nanoparticles
Dongmei Zhao
Key Laboratory of Forest Plant Ecology, Northeast Forestry University, Ministry of Education, Harbin, Heilongjiang, China
Int J Nanomedicine 5:669-77. 2010
..3% and 27.2%, respectively. The amount of folate conjugation was 9.22 μg/mg of bovine serum albumin. The folate-decorated nanoparticles targeted a human prostate cancer cell line effectively...
- Association of oxidative stress and PON1 with LDL and HDL particle size in middle-aged subjects
J Vekic
Institute for Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
Eur J Clin Invest 37:715-23. 2007
..This study investigates the connection between LDL and HDL particle heterogeneity and oxidative stress, antioxidative defence (AOD) and paraoxonase (PON1) status in a healthy middle-aged Serbian population...
- Pulmonary responses of mice, rats, and hamsters to subchronic inhalation of ultrafine titanium dioxide particles
Edilberto Bermudez
CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
Toxicol Sci 77:347-57. 2004
..These differences can be explained both by pulmonary respy response and by particle dosimetry differences among these rodent species...
- Low molecular weight chitosan nanoparticles as new carriers for nasal vaccine delivery in mice
Ana Vila
Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, Santiago de Compostela, Spain
Eur J Pharm Biopharm 57:123-31. 2004
..Furthermore, the response was not influenced by the CS dose (70-200 microg), achieving a significant response for a very low CS dose. In conclusion, nanoparticles made of low Mw CS are promising carriers for nasal vaccine delivery...
- Interaction of gold nanoparticles with common human blood proteins
Silvia H De Paoli Lacerda
Center for Biological Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
ACS Nano 4:365-79. 2010
..K, as well as the degree of cooperativity of particle--protein binding (Hill constant, n), depends on particle size and the native protein structure...
- Nanosuspensions: a promising drug delivery strategy
V B Patravale
Pharmaceutical Division, University Institute of Chemical Technology, Matunga, Mumbai 400 019, India
J Pharm Pharmacol 56:827-40. 2004
..Rapid strides have been made in the delivery of nanosuspensions by parenteral, peroral, ocular and pulmonary routes. Currently, efforts are being directed to extending their applications in site-specific drug delivery...
- Particle size of liposomes influences dermal delivery of substances into skin
D D Verma
Institut für Pharmazeutische Technologie und Biopharmazie, Philipps Universitat Marburg, Ketzerbach 63, 35037, Marburg, Germany
Int J Pharm 258:141-51. 2003
..The results indicated that the CF penetration was inversely related to the size of the liposomes, which was confirmed by the data of the confocal laser scanning microscopy studies...
- Impact of silver nanoparticles on human cells: effect of particle size
Wei Liu
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing, China
Nanotoxicology 4:319-30. 2010
..The findings may assist in the design of SNP applications and provide insights into their toxicity...
- Coarse particles and mortality: evidence from a multi-city study in California
B J Malig
California Office of Environmental Health Hazard Assessment, Oakland, California 94612, USA
Occup Environ Med 66:832-9. 2009
....
- Self-nanoemulsifying drug delivery systems of tamoxifen citrate: design and optimization
Yosra S R Elnaggar
Department of Pharmaceutics, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt yosra
Int J Pharm 380:133-41. 2009
..Realizing drug incorporation into an optimized nano-sized SNEDD system that encompasses a bioactive surfactant, our results proposed that the prepared system could be promising to improve oral efficacy of the tamoxifen citrate...
- Characterization of nanomaterial dispersion in solution prior to in vitro exposure using dynamic light scattering technique
Richard C Murdock
Applied Biotechnology Branch, Human Effectiveness Directorate Air Force Research Laboratory HEPB, Wright Patterson Air Force Board, Ohio 45433, USA
Toxicol Sci 101:239-53. 2008
The need to characterize nanoparticles in solution before assessing the in vitro toxicity is a high priority. Particle size, size distribution, particle morphology, particle composition, surface area, surface chemistry, and particle ..
- The effects of components of fine particulate air pollution on mortality in california: results from CALFINE
Bart Ostro
Office of Environmental Health Hazard Assessment, 16th Floor, 1515 Clay St, Oakland, CA 94612, USA
Environ Health Perspect 115:13-9. 2007
..5 pm in diameter (PM2.5). Little is known, however, about the relative effects of PM2.5 constituents. We examined associations between 19 PM2.5 components and daily mortality in six California counties...
- In vitro toxicity of silica nanoparticles in human lung cancer cells
Weisheng Lin
Department of Chemistry and Environmental Research Center, University of Missouri-Rolla, Rolla, MO 65409, USA
Toxicol Appl Pharmacol 217:252-9. 2006
..In summary, exposure to SiO(2) nanoparticles results in a dose-dependent cytotoxicity in cultural human bronchoalveolar carcinoma-derived cells that is closely correlated to increased oxidative stress...
- Role of target geometry in phagocytosis
Julie A Champion
Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA
Proc Natl Acad Sci U S A 103:4930-4. 2006
..Failure to create the required actin structure results in simple spreading and not internalization. Particle size primarily impacts the completion of phagocytosis in cases where particle volume exceeds the cell volume.
- Associations between air pollution and mortality in Phoenix, 1995-1997
T F Mar
Department of Environmental Health, University of Washington, Seattle, WA 98195 7234, USA
Environ Health Perspect 108:347-53. 2000
..5), PM(10), PM(CF) (p < 0.05), and elemental carbon. Factor analysis revealed that both combustion-related pollutants and secondary aerosols (sulfates) were associated with cardiovascular mortality...
- Quinones and aromatic chemical compounds in particulate matter induce mitochondrial dysfunction: implications for ultrafine particle toxicity
Tian Xia
Division of Clinical Immunology and Allergy, Department of Medicine, UCLA School of Medicine, University of California-Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095-1680, USA
Environ Health Perspect 112:1347-58. 2004
..In contrast, commercial polystyrene nanoparticles failed to exert mitochondrial effects. These results suggest that DEP and UFP effects on the PTP and Delta-Psi m are mediated by adsorbed chemicals rather than the particles themselves...
- Nano/micro technologies for delivering macromolecular therapeutics using poly(D,L-lactide-co-glycolide) and its derivatives
Raghavendra C Mundargi
Industrial Biotechnology Group, Reliance Life Sciences Pvt Ltd, Dhirubhai Ambani Life Sciences Centre, Thane Belapur Road, Rabale, Navi Mumbai 400 701, India
J Control Release 125:193-209. 2008
..Drug encapsulation, particle size, additives added during formulation, molecular weight, ratio of lactide to glycolide moieties in PLGA and ..
- Assessing toxicity of fine and nanoparticles: comparing in vitro measurements to in vivo pulmonary toxicity profiles
Christie M Sayes
DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714, USA
Toxicol Sci 97:163-80. 2007
..It seems clear that in vitro cellular systems will need to be further developed, standardized, and validated (relative to in vivo effects) in order to provide useful screening data on the relative toxicity of inhaled particle types...
- The effect of poloxamer 188 on nanoparticle morphology, size, cancer cell uptake, and cytotoxicity
Fei Yan
The Shenzhen Key Laboratory of Gene and Antibody Therapy, Center for Biotech and Bio Medicine and Division of Life Sciences, Graduate School at Shenzhen, Tsinghua University, Shenzhen, People s Republic of China
Nanomedicine 6:170-8. 2010
..An increased level of uptake of PLGA/poloxamer 188 nanoparticles in resistant human breast cancer cell line was demonstrated, resulting in a significantly higher level of cytotoxicity...
- Macrophage responses to silica nanoparticles are highly conserved across particle sizes
Katrina M Waters
Environmental Biomarkers Program, Pacific Northwest National Laboratory, Richland, Washington 99352, USA
Toxicol Sci 107:553-69. 2009
..However, studies that have assessed the effect of particle size across a comprehensive set of biological responses have not been reported...
- Nano-microparticles as immune adjuvants: correlating particle sizes and the resultant immune responses
Moses O Oyewumi
Department of Pharmaceutical Sciences, Northeastern Ohio Universities Colleges of Medicine and Pharmacy, Rootstown, OH 44272, USA
Expert Rev Vaccines 9:1095-107. 2010
..The information gathered could lead to strategies to optimize the performance of nano-microparticles as immune adjuvants...
- Toxic effects of iron oxide nanoparticles on human umbilical vein endothelial cells
Xinying Wu
Department of Radiology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
Int J Nanomedicine 5:385-99. 2010
....
- Biocompatible nanoscale dispersion of single-walled carbon nanotubes minimizes in vivo pulmonary toxicity
Gokhan M Mutlu
Department of Medicine, Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Evanston, IL 60208, USA
Nano Lett 10:1664-70. 2010
..Biocompatible nanoscale dispersion provides a scalable method to generate purified preparations of SWCNTs with minimal toxicity, thus allowing them to be used safely in commercial and biomedical applications...
- Size-dependent cellular uptake and expulsion of single-walled carbon nanotubes: single particle tracking and a generic uptake model for nanoparticles
Hong Jin
Department of Chemical Engineering, Massachusetts Institute of Technology, Building 66 566, 77 Massachusettes Avenue, Cambridge, Massachusetts 02139 4307, USA
ACS Nano 3:149-58. 2009
..The ability to understand and predict the cellular uptake of nanoparticles quantitatively should find utility in designing nanosystems with controlled toxicity, efficacy, and functionality...
- Cause-specific mortality and the extended effects of particulate pollution and temperature exposure
Patrick G Goodman
School of Physics, Dublin Institute of Technology, and St James Hospital, Dublin, Ireland
Environ Health Perspect 112:179-85. 2004
..This analysis suggests that studies on the acute effects of air pollution have underestimated the total effects of temperature and particulate air pollution on mortality...
- Nanostructured calcium phosphates (NanoCaPs) for non-viral gene delivery: influence of the synthesis parameters on transfection efficiency
Dana Olton
Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA
Biomaterials 28:1267-79. 2007
..In addition, X-ray diffraction and Fourier transform infrared spectroscopy analyses confirmed that all of the synthesized CaP structures exhibited the hydroxyapatite phase...
- Effects of aqueous exposure to silver nanoparticles of different sizes in rainbow trout
Tessa M Scown
Ecotoxicology and Aquatic Biology Research Group, Hatherly Laboratories, School of Biosciences, University of Exeter, Exeter EX4 4PS, UK
Toxicol Sci 115:521-34. 2010
..However, exposure to N(10) particles was found to induce expression of cyp1a2 in the gills, suggesting a possible increase in oxidative metabolism in this tissue...
- Ultrafine particles from diesel vehicle emissions at different driving cycles induce differential vascular pro-inflammatory responses: implication of chemical components and NF-kappaB signaling
Rongsong Li
Biomedical Engineering and Cardiovascular Medicine, USC, Los Angeles, CA 90089, USA
Part Fibre Toxicol 7:6. 2010
..We hypothesize that UFP1 and UFP2 with distinct chemical compositions induce differential pro-inflammatory responses in endothelial cells...
- Extracellular biosynthesis of magnetite using fungi
Atul Bharde
Nanoscience Group, Materials Chemistry Division, National Chemical Laboratory, Pune, India
Small 2:135-41. 2006
....
- Rapid biological synthesis of silver nanoparticles using plant leaf extracts
Jae Yong Song
Department of Chemical Engineering, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea
Bioprocess Biosyst Eng 32:79-84. 2009
..The average particle size ranged from 15 to 500 nm...
- Close encounters of the small kind: adverse effects of man-made materials interfacing with the nano-cosmos of biological systems
Anna A Shvedova
Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, West Virginia University, Morgantown, USA
Annu Rev Pharmacol Toxicol 50:63-88. 2010
..Finally, we highlight in vivo studies of the toxicological outcomes of engineered nanomaterials, including carbon nanotubes, with an emphasis on inflammation and genotoxic responses...
- Enhanced bioavailability of the poorly water-soluble drug fenofibrate by using liposomes containing a bile salt
Yaping Chen
School of Pharmacy, Fudan University, Shanghai, China
Int J Pharm 376:153-60. 2009
..Several properties of the liposomes, including particle size, entrapment efficiency and membrane fluidity, were extensively characterized...
- Ultradeformable cationic liposomes for delivery of small interfering RNA (siRNA) into human primary melanocytes
B Geusens
Department of Dermatology, Ghent University Hospital, Belgium
J Control Release 133:214-20. 2009
..Subsequently, UCL/siRNA complexes were prepared and their particle size, surface charge, deformability, cytotoxicity, transfection efficiency and long-term stability were tested...
- Circulating endothelial microparticles in acute ischemic stroke: a link to severity, lesion volume and outcome
J Simak
Laboratory of Cellular Hematology, CBER, FDA, HFM 335, Rockville, MD 20852 1448, USA
J Thromb Haemost 4:1296-302. 2006
..Endothelial membrane microparticles (EMP) in plasma are elevated in several vascular diseases...
- Elevated plasma endothelial microparticles: preeclampsia versus gestational hypertension
Victor H Gonzalez-Quintero
Division of Maternal Fetal Medicine, Department of Gynecology and Obstetrics, University of Miami School of Medicine, PO Box 016960 R 136, Miami, FL 33101, USA
Am J Obstet Gynecol 191:1418-24. 2004
....
- Physicochemical parameters associated with nanoparticle formation in the salting-out, emulsification-diffusion, and nanoprecipitation methods
Sergio Galindo-Rodriguez
Pharmapeptides, Geneva-Lyon Interuniversity Centre, 74166 Archamps, France
Pharm Res 21:1428-39. 2004
..For nanoprecipitation, chi(solvent-water) and delta(delta solvent-water) of the organic phase solvents were well related to the NP characteristics...
- Cellular cytotoxicity and in-vivo biodistribution of docetaxel poly(lactide-co-glycolide) nanoparticles
Farnaz Esmaeili
Tehran University of Medical Sciences, Iran
Anticancer Drugs 21:43-52. 2010
....
- Formulation optimization for the nanoparticles-in-microsphere hybrid oral delivery system using factorial design
Mayank D Bhavsar
Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston, MA 02115, United States
J Control Release 110:422-30. 2006
..in organic phase, amount of nanoparticles added as internal phase, and the speed of homogenization on particle size of NiMOS using a 3(3) randomized full factorial design...
- Production and characterization of Hesperetin nanosuspensions for dermal delivery
Prabhat R Mishra
Pharmaceutics Division, Central Drug Research Institute, Lucknow 226 001, India
Int J Pharm 371:182-9. 2009
..Slight increases in size were found for the Poloxamer and the Tween stabilized nanosuspensions, which is not considered to impair their use in dermal formulations...
- Does area level socioeconomic status modify the effects of PM(10) on preterm delivery?
Okhee Yi
Department of Epidemiology and Biostatistics, School of Public health and the Institute of Environment and Health, Seoul National University, 28 Yeongeun Dong, Jongro Gu, Seoul, Republic of Korea
Environ Res 110:55-61. 2010
..Recent literature has shown that the neighborhood environment of the mother and child has an independent influence on birth outcomes that was not explained by individual-level risk factors...
- Development and evaluation of penciclovir-loaded solid lipid nanoparticles for topical delivery
Qingzhi Lv
Department of Pharmaceutics, College of Pharmacy, Shandong University, 44 Wenhua Xilu, Jinan, China
Int J Pharm 372:191-8. 2009
..It can be concluded from our study that SLNs provide a good skin targeting effect and may be a promising carrier for topical delivery of penciclovir...
- Covalent attachment of apolipoprotein A-I and apolipoprotein B-100 to albumin nanoparticles enables drug transport into the brain
Jorg Kreuter
Institut fur Pharmazeutische Technologie, Biozentrum, Johann Wolfgang Goethe Universitat Frankfurt, Germany
J Control Release 118:54-8. 2007
..This result demonstrates that more than one mechanism is involved in the interaction of nanoparticles with the brain endothelial cells and the resulting delivery of drugs to the central nervous system...
- Characterization of biophysical and metabolic properties of cells labeled with superparamagnetic iron oxide nanoparticles and transfection agent for cellular MR imaging
Ali S Arbab
Experimental Neuroimaging Section, Laboratory of Diagnostic Radiology Research, National Institutes of Health, 10 Center Dr, Rm B1N256, Bethesda, MD 20892, USA
Radiology 229:838-46. 2003
..To evaluate the effect of using the ferumoxides-poly-l-lysine (PLL) complex for magnetic cell labeling on the long-term viability, function, metabolism, and iron utilization of mammalian cells...
- Deposition and biokinetics of inhaled nanoparticles
Marianne Geiser
Institute of Anatomy, University of Bern, Baltzerstrasse 2, CH 3000 Bern 9, Switzerland
Part Fibre Toxicol 7:2. 2010
..We emphasize the importance for quantitative analyses and the use of particle doses derived from real world exposures...
- Docetaxel microemulsion for enhanced oral bioavailability: preparation and in vitro and in vivo evaluation
Yong Mei Yin
College of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China
J Control Release 140:86-94. 2009
..These results encourage further development of docetaxel microemulsions as an oral drug delivery system...
- Evaluating efficiency-equality tradeoffs for mobile source control strategies in an urban area
Jonathan I Levy
Harvard School of Public Health, Department of Environmental Health, Boston, MA 02215, USA
Risk Anal 29:34-47. 2009
..Our analysis demonstrates the viability of formal analytical approaches to jointly address both efficiency and equality in risk assessment, providing a tool for decisionmakers who wish to consider both issues...
- FeCo/graphitic-shell nanocrystals as advanced magnetic-resonance-imaging and near-infrared agents
Won Seok Seo
Department of Chemistry and Laboratory for Advanced Materials, Stanford University, Stanford, California 94305, USA
Nat Mater 5:971-6. 2006
..These results point to the potential of using these nanocrystals for integrated diagnosis and therapeutic (photothermal-ablation) applications...
- Safety assessment for nanotechnology and nanomedicine: concepts of nanotoxicology
G Oberdorster
Department of Environmental Medicine, University of Rochester, 601 Elmwood Avenue, Medical Center, Rochester, NY 14642, USA
J Intern Med 267:89-105. 2010
....
- Protein adsorption and cellular uptake of cerium oxide nanoparticles as a function of zeta potential
Swanand Patil
Advanced Materials Processing and Analysis Center, Department of Mechanical, Materials and Aerospace Engineering, University of Central Florida, Orlando, FL 32816, USA
Biomaterials 28:4600-7. 2007
..These results demonstrate that electrostatic interactions can play an important factor in protein adsorption and cellular uptake of nanoparticles...
- Increased small low-density lipoprotein particle number: a prominent feature of the metabolic syndrome in the Framingham Heart Study
Sekar Kathiresan
The National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA, USA
Circulation 113:20-9. 2006
..Whereas increased small LDL particle number identified the MetSyn with high sensitivity, a higher small LDL particle number was not associated with greater CVD event rates in people with the MetSyn...
- Endocytosis, oxidative stress and IL-8 expression in human lung epithelial cells upon treatment with fine and ultrafine TiO2: role of the specific surface area and of surface methylation of the particles
Seema Singh
Institut fur umweltmedizinische Forschung IUF an der Heinrich Heine Universitat Dusseldorf gGmbH, Germany
Toxicol Appl Pharmacol 222:141-51. 2007
..However, the responsible mechanisms are not yet fully understood. We investigated the role of particle size and surface chemistry in initiating pro-inflammatory effects in vitro in A549 human lung epithelial cells on ..
- Penetration and distribution of PLGA nanoparticles in the human skin treated with microneedles
Wei Zhang
Department of Pharmaceutics, Changhai Hospital, Second Military Medical University, Shanghai 200433, PR China
Int J Pharm 402:205-12. 2010
..much more nanoparticles deposited in the epidermis than those in the dermis; (iii) the permeation was in a particle size-dependent manner; and (iv) the permeation increased with the nanoparticle concentration increasing until a ..
- Synthesis and characterization of silver/talc nanocomposites using the wet chemical reduction method
Kamyar Shameli
Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, Selangor, Malaysia
Int J Nanomedicine 5:743-51. 2010
..These Ag/talc-NCs may have potential applications in the chemical and biological industries...
- Particulate matter and daily mortality and hospital admissions in the west midlands conurbation of the United Kingdom: associations with fine and coarse particles, black smoke and sulphate
H R Anderson
Department of Public Health Sciences, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
Occup Environ Med 58:504-10. 2001
....
- The effect of air pollution on lung development from 10 to 18 years of age
W James Gauderman
Department of Preventive Medicine, University of Southern California, Los Angeles 90089, USA
N Engl J Med 351:1057-67. 2004
..Whether exposure to air pollution adversely affects the growth of lung function during the period of rapid lung development that occurs between the ages of 10 and 18 years is unknown...
- Molecular interactions alter clay and polymer structure in polymer clay nanocomposites
Debashis Sikdar
Department of Civil Engineering, North Dakota State University, Fargo, ND 58105, USA
J Nanosci Nanotechnol 8:1638-57. 2008
..Thus, the mechanisms governing composite action in nanocomposites are quite different from that of conventional macro composites...
- Conducting polymer/clay nanocomposites and their applications
Fei Fei Fang
Department of Polymer Science and Engineering, Inha University, Incheon 402 751, Korea
J Nanosci Nanotechnol 8:1559-81. 2008
..Attentions are also being paid on conductive/magnetic performances as well as two potential applications in anti-corrosion coating and electrorheological (ER) fluids...
- Characterizing poly(epsilon-caprolactone)-b-chitooligosaccharide-b-poly(ethylene glycol) (PCP) copolymer micelles for doxorubicin (DOX) delivery: effects of crosslinked of amine groups
Tze-Wen Chung
Department of Chemical Engineering, National Yunlin University of Science and Technology, Tou-Liu, Yunlin, 640 Taiwan, ROC
J Nanosci Nanotechnol 6:2902-11. 2006
..Further applications of PCP copolymers and micelles for drug delivery can be explored in future...
