particle size

Summary

Top Publications

  1. ncbi Toxic potential of materials at the nanolevel
    Andre Nel
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Science 311:622-7. 2006
  2. ncbi Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology
    Marie Christine Daniel
    Molecular Nanosciences and Catalysis Group, LCOO, UMR CNRS No 5802, Universite Bordeaux I, 33405 Talence Cedex, France
    Chem Rev 104:293-346. 2004
  3. ncbi Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications
    Ajay Kumar Gupta
    Crusade Laboratories Limited, Southern General Hospital, 1345 Govan Road, Glasgow G51 4TF, Scotland, UK
    Biomaterials 26:3995-4021. 2005
  4. ncbi Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells
    B Devika Chithrani
    Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada
    Nano Lett 6:662-8. 2006
  5. ncbi Elucidating the mechanism of cellular uptake and removal of protein-coated gold nanoparticles of different sizes and shapes
    B Devika Chithrani
    Institute of Biomaterials and Biomedical Engineering, Terrence Donnelly Center for Cellular and Biomolecular Research, University of Toronto, 160 College Street, 4th Floor, Toronto, Ontario M5S 3G9, Canada
    Nano Lett 7:1542-50. 2007
  6. pmc Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles
    Gunter Oberdorster
    Department of Environmental Medicine, University of Rochester, Rochester, New York 14642, USA
    Environ Health Perspect 113:823-39. 2005
  7. doi Understanding biophysicochemical interactions at the nano-bio interface
    Andre E Nel
    Division of NanoMedicine, David Geffen School of Medicine and California NanoSystems Institute at UCLA, Los Angeles, California 90095, USA
    Nat Mater 8:543-57. 2009
  8. doi Effect of surface properties on nanoparticle-cell interactions
    Ayush Verma
    Department of Materials Science and Engineering, Massachusetts Institute of Technology MIT, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Small 6:12-21. 2010
  9. pmc Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis
    Joanna Rejman
    Department of Membrane Cell Biology, University of Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Biochem J 377:159-69. 2004
  10. pmc Understanding the nanoparticle-protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles
    Tommy Cedervall
    School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland
    Proc Natl Acad Sci U S A 104:2050-5. 2007

Detail Information

Publications282 found, 100 shown here

  1. ncbi Toxic potential of materials at the nanolevel
    Andre Nel
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Science 311:622-7. 2006
    ..The establishment of principles and test procedures to ensure safe manufacture and use of nanomaterials in the marketplace is urgently required and achievable...
  2. ncbi Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology
    Marie Christine Daniel
    Molecular Nanosciences and Catalysis Group, LCOO, UMR CNRS No 5802, Universite Bordeaux I, 33405 Talence Cedex, France
    Chem Rev 104:293-346. 2004
  3. ncbi Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications
    Ajay Kumar Gupta
    Crusade Laboratories Limited, Southern General Hospital, 1345 Govan Road, Glasgow G51 4TF, Scotland, UK
    Biomaterials 26:3995-4021. 2005
    ..that these nanoparticles have high magnetization values and size smaller than 100 nm with overall narrow particle size distribution, so that the particles have uniform physical and chemical properties...
  4. ncbi Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells
    B Devika Chithrani
    Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada
    Nano Lett 6:662-8. 2006
    ..g., tuning intracellular delivery rates and amounts by nanoscale dimensions and engineering complex, multifunctional nanostructures for imaging and therapeutics)...
  5. ncbi Elucidating the mechanism of cellular uptake and removal of protein-coated gold nanoparticles of different sizes and shapes
    B Devika Chithrani
    Institute of Biomaterials and Biomedical Engineering, Terrence Donnelly Center for Cellular and Biomolecular Research, University of Toronto, 160 College Street, 4th Floor, Toronto, Ontario M5S 3G9, Canada
    Nano Lett 7:1542-50. 2007
    ..These studies will provide guidelines for developing NPs for imaging and drug delivery applications, which will require "controlling" NP accumulation rate. These studies will also have implications in determining nanotoxicity...
  6. pmc Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles
    Gunter Oberdorster
    Department of Environmental Medicine, University of Rochester, Rochester, New York 14642, USA
    Environ Health Perspect 113:823-39. 2005
    ..An interdisciplinary team approach (e.g., toxicology, materials science, medicine, molecular biology, and bioinformatics, to name a few) is mandatory for nanotoxicology research to arrive at an appropriate risk assessment...
  7. doi Understanding biophysicochemical interactions at the nano-bio interface
    Andre E Nel
    Division of NanoMedicine, David Geffen School of Medicine and California NanoSystems Institute at UCLA, Los Angeles, California 90095, USA
    Nat Mater 8:543-57. 2009
    ..This knowledge is important from the perspective of safe use of nanomaterials...
  8. doi Effect of surface properties on nanoparticle-cell interactions
    Ayush Verma
    Department of Materials Science and Engineering, Massachusetts Institute of Technology MIT, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Small 6:12-21. 2010
    ..Challenges for undertaking a systematic study to elucidate nanoparticle-cell interactions are also discussed...
  9. pmc Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis
    Joanna Rejman
    Department of Membrane Cell Biology, University of Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Biochem J 377:159-69. 2004
    ..In the present study, we have investigated the effect of particle size on the pathway of entry and subsequent intracellular fate in non-phagocytic B16 cells, using a range of ..
  10. pmc Understanding the nanoparticle-protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles
    Tommy Cedervall
    School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland
    Proc Natl Acad Sci U S A 104:2050-5. 2007
    ..The kinetic and equilibrium binding properties depend on protein identity as well as particle surface characteristics and size...
  11. ncbi Strategies in the design of nanoparticles for therapeutic applications
    Robby A Petros
    Department of Chemistry, University of North Texas, Denton, Texas 76203, USA
    Nat Rev Drug Discov 9:615-27. 2010
    ..This Review focuses on recent progress important for the rational design of such nanoparticles and discusses the challenges to realizing the potential of nanoparticles...
  12. ncbi Size-dependent cytotoxicity of gold nanoparticles
    Yu Pan
    Biomedical Engineering, Biointerface Laboratory, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany
    Small 3:1941-9. 2007
    ..The cellular response is size dependent, in that 1.4-nm particles cause predominantly rapid cell death by necrosis within 12 h while closely related particles 1.2 nm in diameter effect predominantly programmed cell death by apoptosis...
  13. doi PVP-coated silver nanoparticles and silver ions induce reactive oxygen species, apoptosis and necrosis in THP-1 monocytes
    Rasmus Foldbjerg
    Department of Environmental and Occupational Medicine, Institute of Public Health, Aarhus University, Bartholins Alle 2, Bygn 1260, 8000 Aarhus, Denmark
    Toxicol Lett 190:156-62. 2009
    ..A drastic increase in ROS levels could be detected after 6-24h suggesting that oxidative stress is an important mediator of cytotoxicity caused by Ag NPs and Ag+...
  14. ncbi Calculated absorption and scattering properties of gold nanoparticles of different size, shape, and composition: applications in biological imaging and biomedicine
    Prashant K Jain
    Laser Dynamics Laboratory, School of Chemistry and Biochemistry, Georgia, Institute of Technology, Atlanta, Georgia 30332 0400, USA
    J Phys Chem B 110:7238-48. 2006
    ....
  15. pmc Factors affecting the clearance and biodistribution of polymeric nanoparticles
    Frank Alexis
    Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Pharm 5:505-15. 2008
    ....
  16. pmc Renal clearance of quantum dots
    Hak Soo Choi
    Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Room SL B05, Boston, Massachusetts 02215, USA
    Nat Biotechnol 25:1165-70. 2007
    ..5 nm resulted in rapid and efficient urinary excretion and elimination of quantum dots from the body. This study provides a foundation for the design and development of biologically targeted nanoparticles for biomedical applications...
  17. pmc A toxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors
    Ron Hardman
    Nicholas School of the Environment and Earth Sciences, Duke University, Durham, North Carolina 27708, USA
    Environ Health Perspect 114:165-72. 2006
    ..Key words: environment, human health, nanomaterials, nanosized particles, nanotechnology, nanotoxicology, quantum dots, toxicology...
  18. ncbi Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration
    Jiangxue Wang
    Laboratory for Bio Environmental Effects of Nanomaterials and Nanosafety and Key Laboratory of Nuclear Analytical Techniques, National Center for NanoScience and Technology and Institute of High Energy Physics, Beijing 100080, PR China
    Toxicol Lett 168:176-85. 2007
    ..Biodistribution experiment showed that TiO(2) mainly retained in the liver, spleen, kidneys, and lung tissues, which indicated that TiO(2) particles could be transported to other tissues and organs after uptake by gastrointestinal tract...
  19. ncbi Curcumin and its nano-formulation: the kinetics of tissue distribution and blood-brain barrier penetration
    Yin Meng Tsai
    Institute of Traditional Medicine, National Yang Ming University, Taipei, Taiwan
    Int J Pharm 416:331-8. 2011
    ..The mean particle size and entrapment efficiency were 163nm and 46.9%, respectively...
  20. doi Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles
    Chunbai He
    State Key Laboratory of Genetic Engineering, Department of Pharmaceutical Sciences, School of Life Sciences, Fudan University, Shanghai 200433, China
    Biomaterials 31:3657-66. 2010
    To elucidate the effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles (NPs), rhodamine B (RhB) labeled carboxymethyl chitosan grafted NPs (RhB-CMCNP) and chitosan hydrochloride ..
  21. ncbi Particle size-dependent organ distribution of gold nanoparticles after intravenous administration
    Wim H De Jong
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment RIVM, Antonie van Leeuwenhoeklaan 9, Bilthoven, The Netherlands
    Biomaterials 29:1912-9. 2008
    A kinetic study was performed to determine the influence of particle size on the in vivo tissue distribution of spherical-shaped gold nanoparticles in the rat...
  22. pmc Asbestos, carbon nanotubes and the pleural mesothelium: a review of the hypothesis regarding the role of long fibre retention in the parietal pleura, inflammation and mesothelioma
    Ken Donaldson
    University of Edinburgh, Centre for Inflammation Research, Queens Medical Research Institute, 47 Little France Crescent, Edinburgh EH164TJ, UK
    Part Fibre Toxicol 7:5. 2010
    ....
  23. doi Silver nanoparticles as a new generation of antimicrobials
    Mahendra Rai
    Department of Biotechnology, SGB Amravati University, Amravati 444 602, Maharashtra, India
    Biotechnol Adv 27:76-83. 2009
    ..Hence, silver nanoparticles have emerged up with diverse medical applications ranging from silver based dressings, silver coated medicinal devices, such as nanogels, nanolotions, etc...
  24. ncbi Solid lipid nanoparticles: production, characterization and applications
    W Mehnert
    Institute of Pharmacy, Department of Pharmaceutical Technology, Free University of Berlin, Kelchstr 31, D 12169, Berlin, Germany
    Adv Drug Deliv Rev 47:165-96. 2001
    ..The use of several analytical techniques is a necessity. Alternative structures and dynamic phenomena on the molecular level have to be considered. Aspects of SLN administration and the in vivo fate of the carrier are discussed...
  25. doi Stability and aggregation of metal oxide nanoparticles in natural aqueous matrices
    Arturo A Keller
    University of California, Santa Barbara, USA
    Environ Sci Technol 44:1962-7. 2010
    ..8 microm s(-1) V(-1) cm. These results are key for designing and interpreting nanoparticle ecotoxicity studies in various environmental conditions...
  26. ncbi Cytotoxicity of nanoparticles independent from oxidative stress
    Eleonore Fröhlich
    Center for Medical Research, Medical University of Graz, A 8010 Graz, Austria
    J Toxicol Sci 34:363-75. 2009
    ..Protein containing solutions led to increases in particle size, decreased cytotoxicity and reduced cellular uptake...
  27. ncbi Nanomedicine: current status and future prospects
    S Moein Moghimi
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy, University of Brighton, Brighton, UK
    FASEB J 19:311-30. 2005
    ..Potential pitfalls or side effects associated with nanoparticles are also discussed...
  28. doi Cellular responses induced by silver nanoparticles: In vitro studies
    S Arora
    Centre for Nanobioscience, Agharkar Research Institute, G G Agarkar Road, Pune 411004, India
    Toxicol Lett 179:93-100. 2008
    ..5 microg/mL in both cell types). These results can be used to define a safe range of SNP for the intended application as a topical antimicrobial agent after appropriate in vivo studies...
  29. doi Preparation and evaluation of self-microemulsifying drug delivery system of oridonin
    Ping Zhang
    School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 210203, PR China
    Int J Pharm 355:269-76. 2008
    ..The absorption of oridonin from SMEDDS showed a 2.2-fold increase in relative bioavailability compared with that of the suspension. Our studies demonstrated the promising use of SMEDDS for the delivery of oridonin by the oral route...
  30. ncbi Recent advances in iron oxide nanocrystal technology for medical imaging
    Claire Corot
    Guerbet Research, BP 57400, 95943 Roissy CDG, France
    Adv Drug Deliv Rev 58:1471-504. 2006
    ..Stem cell migration and immune cell trafficking, as well as targeted iron oxide nanoparticles for molecular imaging studies, are at the stage of proof of concept, mainly in animal models...
  31. doi Uptake and intracellular fate of surface-modified gold nanoparticles
    Paola Nativo
    Department of Chemistry, University of Liverpool, Liverpool, United Kingdom
    ACS Nano 2:1639-44. 2008
    ..Successful nuclear targeting is demonstrated using surface modification with a cocktail of CPPs and a peptide acting as a nuclear localization signal (NLS)...
  32. doi Nanoparticle-mediated cellular response is size-dependent
    Wen Jiang
    Nat Nanotechnol 3:145-50. 2008
    ..The findings presented here may assist in the design of nanoscale delivery and therapeutic systems and provide insights into nanotoxicity...
  33. pmc Surface-structure-regulated cell-membrane penetration by monolayer-protected nanoparticles
    Ayush Verma
    Department of Materials Science and Engineering, MIT, Massachusetts 02139, USA
    Nat Mater 7:588-95. 2008
    ..Our results offer a paradigm for analysing the fundamental problem of cell-membrane-penetrating bio- and macro-molecules...
  34. ncbi Characterization of nanoparticle uptake by endothelial cells
    Jasmine Davda
    Department of Pharmaceutical Sciences, College of Pharmacy, 986025 Nebraska Medical Center, Omaha, NE 68198 6025, USA
    Int J Pharm 233:51-9. 2002
    ..Nanoparticles localized in the endothelium could provide prolonged drug effects because of their sustained release characterics, and also could protect the encapsulated agent from enzymatic degradation...
  35. ncbi Silver colloid nanoparticles: synthesis, characterization, and their antibacterial activity
    Ales Panacek
    Department of Physical Chemistry, Palacky University, Svobody 26, 771 46 Olomouc, Czech Republic
    J Phys Chem B 110:16248-53. 2006
    ..Antibacterial activity of silver nanoparticles was found to be dependent on the size of silver particles. A very low concentration of silver (as low as 1.69 mug/mL Ag) gave antibacterial performance...
  36. ncbi Unique cellular interaction of silver nanoparticles: size-dependent generation of reactive oxygen species
    C Carlson
    Applied Biotechnology Branch, Human Effectiveness Directorate, Wright Patterson Air Force Base, Dayton, Ohio 45433, USA
    J Phys Chem B 112:13608-19. 2008
    ..In summary, a size-dependent toxicity was produced by silver nanoparticles, and one predominant mechanism of toxicity was found to be largely mediated through oxidative stress...
  37. doi Evaluating the uptake and intracellular fate of polystyrene nanoparticles by primary and hepatocyte cell lines in vitro
    Helinor J Johnston
    Biomedicine and Sport and Exercise Science Research Group, School of Life Sciences, Edinburgh Napier University, Edinburgh EH10 5DT, UK
    Toxicol Appl Pharmacol 242:66-78. 2010
    ..The findings were, in the main, comparable between primary rat hepatocytes and the different human hepatocyte cell lines...
  38. doi Endocytosis at the nanoscale
    Irene Canton
    The Krebs Institute, The Centre for Membrane Interaction and Dynamics, The Sheffield Cancer Research Centre, and the Department of Biomedical Science, The University of Sheffield, Western Bank, Sheffield, S10 2TN, UK
    Chem Soc Rev 41:2718-39. 2012
    ..Finally, we discuss different drug delivery strategies on how to evade lysosomal degradation to promote effective release of the cargo (376 references)...
  39. ncbi Surface-modified superparamagnetic nanoparticles for drug delivery: preparation, characterization, and cytotoxicity studies
    Ajay Kumar Gupta
    Centre for Cell Engineering, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
    IEEE Trans Nanobioscience 3:66-73. 2004
    ....
  40. pmc A high-performance nanobio photocatalyst for targeted brain cancer therapy
    Elena A Rozhkova
    The Center for Nanoscale Materials, Argonne National Laboratory, Argonne, Illinois 60439, USA
    Nano Lett 9:3337-42. 2009
    ..Synchrotron X-ray fluorescence microscopy (XFM) was applied for direct visualization of the nanobioconjugate distribution through a single brain cancer cell at the submicrometer scale...
  41. pmc The effect of particle design on cellular internalization pathways
    Stephanie E A Gratton
    Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 105:11613-8. 2008
    The interaction of particles with cells is known to be strongly influenced by particle size, but little is known about the interdependent role that size, shape, and surface chemistry have on cellular internalization and intracellular ..
  42. ncbi Residual polyvinyl alcohol associated with poly (D,L-lactide-co-glycolide) nanoparticles affects their physical properties and cellular uptake
    Sanjeeb K Sahoo
    Department of Pharmaceutical Sciences, University of Nebraska Medical Center 986025, Omaha, NE 68198 6025, USA
    J Control Release 82:105-14. 2002
    ..The residual PVA, in turn, influenced different pharmaceutical properties of nanoparticles such as particle size, zeta potential, polydispersity index, surface hydrophobicity, protein loading and also slightly influenced ..
  43. pmc The effect of sedimentation and diffusion on cellular uptake of gold nanoparticles
    Eun Chul Cho
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    Nat Nanotechnol 6:385-91. 2011
    ..Our results suggest that sedimentation needs to be considered when performing in vitro studies for large and/or heavy nanoparticles...
  44. doi Cellular uptake, cytotoxicity, and innate immune response of silica-titania hollow nanoparticles based on size and surface functionality
    Wan Kyu Oh
    School of Chemical and Biological Engineering, Seoul National University, 599 Gwanangro, Gwanak Gu, Seoul 151 742, Korea
    ACS Nano 4:5301-13. 2010
    ..These findings provide size- and surface functionality-dependent nanotoxicity and uptake of HNPs, and lead to HNPs for bioapplications such as drug delivery and imaging probe...
  45. ncbi Characterization of nanomaterial dispersion in solution prior to in vitro exposure using dynamic light scattering technique
    Richard C Murdock
    Applied Biotechnology Branch, Human Effectiveness Directorate Air Force Research Laboratory HEPB, Wright Patterson Air Force Board, Ohio 45433, USA
    Toxicol Sci 101:239-53. 2008
    The need to characterize nanoparticles in solution before assessing the in vitro toxicity is a high priority. Particle size, size distribution, particle morphology, particle composition, surface area, surface chemistry, and particle ..
  46. pmc Time-series analysis of mortality effects of fine particulate matter components in Detroit and Seattle
    Jiang Zhou
    New York University School of Medicine, Tuxedo, New York 10987, USA
    Environ Health Perspect 119:461-6. 2011
    ..Recent toxicological and epidemiological studies have shown associations between particulate matter (PM) and adverse health effects, but which PM components are most influential is less well known...
  47. doi Silica and titanium dioxide nanoparticles cause pregnancy complications in mice
    Kohei Yamashita
    Department of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565 0871, Japan
    Nat Nanotechnol 6:321-8. 2011
    ..These detrimental effects are linked to structural and functional abnormalities in the placenta on the maternal side, and are abolished when the surfaces of the silica nanoparticles are modified with carboxyl and amine groups...
  48. doi Optimization and characterization of anionic lipoplexes for gene delivery
    Charudharshini Srinivasan
    Department of Pharmaceutical Sciences, University of Connecticut, 69 North Eagleville Road, Unit 3092, Storrs, CT 06269, USA
    J Control Release 136:62-70. 2009
    ..8 microg plasmid DNA. Biophysical studies (particle size analysis, gel electrophoresis, transmission electron microscopy (TEM), and confocal microscopy) were conducted ..
  49. ncbi The kinetics of the tissue distribution of silver nanoparticles of different sizes
    D P K Lankveld
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment RIVM, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Biomaterials 31:8350-61. 2010
    ..Model parameter values were estimated by fitting to data. No clear relation between parameter values and corresponding particle diameters became apparent...
  50. ncbi Translocation of inhaled ultrafine particles to the brain
    G Oberdorster
    Department of Environmental Medicine, University of Rochester, Rochester, New York 14642, USA
    Inhal Toxicol 16:437-45. 2004
    ..Depending on their particle size, inhaled UFP are efficiently deposited in nasal, tracheobronchial, and alveolar regions due to diffusion...
  51. ncbi Biodistribution of colloidal gold nanoparticles after intravenous administration: effect of particle size
    Ganeshchandra Sonavane
    Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, Japan
    Colloids Surf B Biointerfaces 66:274-80. 2008
    ..Another objective was to study effect of particle size on biological distribution of gold NP to enable their diverse applications in nanotechnology...
  52. pmc Spatial and temporal variation in PM(2.5) chemical composition in the United States for health effects studies
    Michelle L Bell
    School of Forestry and Environmental Studies, Yale University, New Haven, Connecticut, USA
    Environ Health Perspect 115:989-95. 2007
    ..Although numerous studies have demonstrated links between particulate matter (PM) and adverse health effects, the chemical components of the PM mixture that cause injury are unknown...
  53. ncbi Large porous particles for pulmonary drug delivery
    D A Edwards
    Department of Chemical Engineering, Pennsylvania State University, 204 Fenske Laboratory, University Park, PA 16802, USA
    Science 276:1868-71. 1997
    ..High systemic bioavailability of testosterone was also achieved by inhalation delivery of porous particles with a mean diameter (20 micrometers) approximately 10 times that of conventional inhaled therapeutic particles...
  54. ncbi Oxide nanoparticle uptake in human lung fibroblasts: effects of particle size, agglomeration, and diffusion at low concentrations
    Ludwig K Limbach
    Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zurich, Switzerland
    Environ Sci Technol 39:9370-6. 2005
    ..but physiologically relevant concentrations reveal a strong dependence of the amount of incorporated ceria on particle size, while nanoparticle number density or total particle surface area are of minor importance...
  55. pmc Mechanics of receptor-mediated endocytosis
    Huajian Gao
    Max Planck Institute for Metals Research, Heisenbergstrasse 3, D 70569 Stuttgart, Germany
    Proc Natl Acad Sci U S A 102:9469-74. 2005
    ..This model can also be extended to include the effect of clathrin coat. The results seem to show broad agreement with experimental observations...
  56. pmc Effects of prenatal exposure to surface-coated nanosized titanium dioxide (UV-Titan). A study in mice
    Karin S Hougaard
    National Research Centre for the Working Environment, Copenhagen Ø, Denmark
    Part Fibre Toxicol 7:16. 2010
    ..Consequently, also toxicological properties may change compared to the parent compound. We examined developmental and neurobehavioral effects following maternal exposure to a nanoparticulate UV-filter (UV-titan L181)...
  57. doi Mediating tumor targeting efficiency of nanoparticles through design
    Steven D Perrault
    Institute of Biomaterials and Biomedical Engineering, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, ON, M5S 3E1, Canada
    Nano Lett 9:1909-15. 2009
    ..Our results provide design parameters for engineering nanoparticles for optimized tumor targeting of contrast agents and therapeutics...
  58. pmc Fine particulate matter constituents associated with cardiovascular hospitalizations and mortality in New York City
    Kazuhiko Ito
    New York University School of Medicine, Tuxedo, New York 10987, USA
    Environ Health Perspect 119:467-73. 2011
    ..We investigated this issue in New York City (NYC), where PM originates from regional and local combustion sources...
  59. ncbi In vitro toxicity of silica nanoparticles in human lung cancer cells
    Weisheng Lin
    Department of Chemistry and Environmental Research Center, University of Missouri Rolla, Rolla, MO 65409, USA
    Toxicol Appl Pharmacol 217:252-9. 2006
    ..In summary, exposure to SiO(2) nanoparticles results in a dose-dependent cytotoxicity in cultural human bronchoalveolar carcinoma-derived cells that is closely correlated to increased oxidative stress...
  60. pmc Particle size, surface coating, and PEGylation influence the biodistribution of quantum dots in living mice
    Meike L Schipper
    Molecular Imaging Program at Stanford MIPS, Department of Radiology, Bio X Program, Stanford University, 318 Campus Drive, Palo Alto, CA 94305 5427, USA
    Small 5:126-34. 2009
    This study evaluates the influence of particle size, PEGylation, and surface coating on the quantitative biodistribution of near-infrared-emitting quantum dots (QDs) in mice...
  61. doi Nanocarriers' entry into the cell: relevance to drug delivery
    Hervé Hillaireau
    School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA
    Cell Mol Life Sci 66:2873-96. 2009
    ..Nevertheless, various strategies are being actively investigated in order to tailor nanocarriers able to deliver anticancer agents, nucleic acids, proteins and peptides for therapeutic applications by these non-phagocytic routes...
  62. doi Paclitaxel-loaded PEGylated PLGA-based nanoparticles: in vitro and in vivo evaluation
    Fabienne Danhier
    Universite Catholique de Louvain, Unite de Pharmacie Galenique, Avenue Mounier, 73 20, 1200 Brussels, Belgium
    J Control Release 133:11-7. 2009
    ..Therefore, PTX-loaded nanoparticles may be considered as an effective anticancer drug delivery system for cancer chemotherapy...
  63. pmc The effect of fine and coarse particulate air pollution on mortality: a national analysis
    Antonella Zanobetti
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Environ Health Perspect 117:898-903. 2009
    ..5) and PM coarse on the increased risk of death for all causes, cardiovascular disease (CVD), myocardial infarction (MI), stroke, and respiratory mortality for the years 1999-2005...
  64. pmc Protein adsorption and cellular uptake of cerium oxide nanoparticles as a function of zeta potential
    Swanand Patil
    Advanced Materials Processing and Analysis Center, Department of Mechanical, Materials and Aerospace Engineering, University of Central Florida, Orlando, FL 32816, USA
    Biomaterials 28:4600-7. 2007
    ..These results demonstrate that electrostatic interactions can play an important factor in protein adsorption and cellular uptake of nanoparticles...
  65. doi Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size
    H Cabral
    Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Hongo, Bunkyo ku, Japan
    Nat Nanotechnol 6:815-23. 2011
    ..We also showed that the penetration and efficacy of the larger micelles could be enhanced by using a transforming growth factor-β inhibitor to increase the permeability of the tumours...
  66. pmc Influence of apolipoprotein (Apo) A-I structure on nascent high density lipoprotein (HDL) particle size distribution
    Charulatha Vedhachalam
    Lipid Research Group, Gastroenterology, Hepatology, and Nutrition Division, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4318, USA
    J Biol Chem 285:31965-73. 2010
    ..The stability of the apoA-I N-terminal helix bundle domain and the hydrophobicity of the C-terminal domain are important determinants of both nascent HDL particle size and their rate of formation.
  67. ncbi Ceramic-based nanoparticles entrapping water-insoluble photosensitizing anticancer drugs: a novel drug-carrier system for photodynamic therapy
    Indrajit Roy
    Institute of Lasers, Photonics and Biophotonics, Department of Chemistry, State University of New York, Buffalo, NY 14260 3000, USA
    J Am Chem Soc 125:7860-5. 2003
    ..Significant damage to such impregnated tumor cells was observed upon irradiation with light of wavelength 650 nm. Thus, the potential of using ceramic-based nanoparticles as drug carriers for photodynamic therapy has been demonstrated...
  68. ncbi Size-dependency of nanoparticle-mediated gene transfection: studies with fractionated nanoparticles
    Swayam Prabha
    Department of Pharmaceutical Sciences, 986025 University of Nebraska Medical Center, Omaha, NE 68198 6025, USA
    Int J Pharm 244:105-15. 2002
    ..The results suggest that the particle size is an important factor, and that the smaller-sized fraction of the nanoparticle formulation predominantly ..
  69. pmc The impact of polycyclic aromatic hydrocarbons and fine particles on pregnancy outcome
    J Dejmek
    Laboratory of Genetic Ecotoxicology, Regional Institute of Hygiene of Central Bohemia and Institute of Experimental Medicine, Academy of Science of the Czech Republic, Prague, Czech Republic
    Environ Health Perspect 108:1159-64. 2000
    ..The results prove that exposure to c-PAHs in early gestation may influence fetal growth. The particulate matter-IUGR association observed earlier may be at least partly explained by the presence of c-PAHs on particle surfaces...
  70. pmc Human serum albumin nanoparticles as an efficient noscapine drug delivery system for potential use in breast cancer: preparation and in vitro analysis
    Safaa Sebak
    Biomedical Technology and Cell Therapy Research Laboratory, Department of Biomedical Engineering, Faculty of Medicine, McGill University, Montreal, Quebec, Canada
    Int J Nanomedicine 5:525-32. 2010
    ..The nanoparticles were designed and optimized to achieve a particle size in the range of 150-300 nm with a drug-loading efficiency of 85%-96%...
  71. pmc Chronic fine and coarse particulate exposure, mortality, and coronary heart disease in the Nurses' Health Study
    ROBIN C PUETT
    South Carolina Cancer Prevention and Control Program and Department of Epidemiology, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina 29201, USA
    Environ Health Perspect 117:1697-701. 2009
    ..5 and 10 microm (PM(10-2.5)), may also be important. With respect to mortality and cardiovascular events, questions remain regarding the relative strength of effect sizes for chronic exposure to fine and coarse particles...
  72. pmc Ambient air pollution and low birth weight in Connecticut and Massachusetts
    Michelle L Bell
    School of Forestry and Environmental Studies, Yale University, New Haven, Connecticut 06511, USA
    Environ Health Perspect 115:1118-24. 2007
    ..Several studies have examined whether air pollution affects birth weight; however results vary and many studies were focused on Southern California or were conducted outside of the United States...
  73. ncbi The use of hypromellose in oral drug delivery
    Chi L Li
    GlaxoSmithKline Pharmaceuticals, Pharmaceutical Development, New Frontiers Science Park South, Third Avenue, Harlow, Essex, CM19 5AW, UK
    J Pharm Pharmacol 57:533-46. 2005
    ....
  74. ncbi Woodsmoke health effects: a review
    Luke P Naeher
    Department of Environmental Health Science, College of Public Health, University of Georgia, Athens, Georgia, USA
    Inhal Toxicol 19:67-106. 2007
    ..In addition, we provide recommendations for additional woodsmoke research...
  75. ncbi Circulating microparticles: pathophysiology and clinical implications
    Andrea Piccin
    Irish Blood Transfusion Service, James s Street, Dublin 8, Ireland
    Blood Rev 21:157-71. 2007
    ..In addition the complex role of microparticles in vascular and cardiovascular diseases is an area of immense interest, that promises to yield important advances into diagnosis and therapy...
  76. doi Copper oxide nanoparticles are highly toxic: a comparison between metal oxide nanoparticles and carbon nanotubes
    Hanna L Karlsson
    Department of Biosciences and Nutrition at Novum, Karolinska Institutet, Stockholm, Sweden
    Chem Res Toxicol 21:1726-32. 2008
    ..The effects were not explained by soluble metal impurities. In conclusion, this study highlights the in vitro toxicity of CuO nanoparticles...
  77. ncbi Health effects of fine particulate air pollution: lines that connect
    C Arden Pope
    Department of Economics, Brigham Young University, Provo, UT 84602 2363, USA
    J Air Waste Manag Assoc 56:709-42. 2006
    ....
  78. pmc Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution
    C Arden Pope
    Department of Economics, Brigham Young University, 142 FOB, Provo, UT 84602, USA
    JAMA 287:1132-41. 2002
    ..However, studies of health effects of long-term particulate air pollution have been less conclusive...
  79. doi A review of the in vivo and in vitro toxicity of silver and gold particulates: particle attributes and biological mechanisms responsible for the observed toxicity
    Helinor J Johnston
    Centre for Nano Safety, School of Life Sciences, Edinburgh Napier University, Edinburgh, UK
    Crit Rev Toxicol 40:328-46. 2010
    ..Alternatively, a combination of both may be responsible, as the release of ions would be expected to be greater for smaller particles...
  80. ncbi A review of carbon nanotube toxicity and assessment of potential occupational and environmental health risks
    Chiu wing Lam
    JSC Toxicology Group, Space Life Sciences, NASA Johnson Space Center, Wyle Laboratories and Department of Pathology and Laboratory Medicine, University of Texas Medical School, Houston, Texas 77058, USA
    Crit Rev Toxicol 36:189-217. 2006
    ..Therefore, CNTs from manufactured and combustion sources in the environment could have adverse effects on human health...
  81. ncbi Gastrointestinal persorption and tissue distribution of differently sized colloidal gold nanoparticles
    J F Hillyer
    Department of Animal Health and Biomedical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 1656 Linden Drive, Madison, Wisconsin 53706, USA
    J Pharm Sci 90:1927-36. 2001
    ..In our quantitative studies we found that colloidal gold uptake is dependent on particle size: smaller particles cross the gastrointestinal tract more readily...
  82. pmc Gold nanoparticles administration induced prominent inflammatory, central vein intima disruption, fatty change and Kupffer cells hyperplasia
    Mohamed Anwar K Abdelhalim
    Department of Physics and Astronomy, College of Science, King Saud University, Saudi Arabia
    Lipids Health Dis 10:133. 2011
    ....
  83. ncbi Size-dependent proinflammatory effects of ultrafine polystyrene particles: a role for surface area and oxidative stress in the enhanced activity of ultrafines
    D M Brown
    School of Life Sciences, Napier University, 10 Colinton Road, Edinburgh EH10 5DT, Scotland
    Toxicol Appl Pharmacol 175:191-9. 2001
    ..the effects of ultrafine particles in the lung have shown adverse effects considered to be due in part to the particle size. Air pollution particles (PM(10)) are associated with exacerbations of respiratory disease and deaths from ..
  84. ncbi Low molecular weight chitosan nanoparticles as new carriers for nasal vaccine delivery in mice
    Ana Vila
    Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, Santiago de Compostela, Spain
    Eur J Pharm Biopharm 57:123-31. 2004
    ..Furthermore, the response was not influenced by the CS dose (70-200 microg), achieving a significant response for a very low CS dose. In conclusion, nanoparticles made of low Mw CS are promising carriers for nasal vaccine delivery...
  85. doi Impact of silver nanoparticles on human cells: effect of particle size
    Wei Liu
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing, China
    Nanotoxicology 4:319-30. 2010
    ..The findings may assist in the design of SNP applications and provide insights into their toxicity...
  86. doi The impact of size on tissue distribution and elimination by single intravenous injection of silica nanoparticles
    Minjung Cho
    Division of Toxicologic Pathology, National Institute of Toxicological Research, Korea Food and Drug Administration, 231 Jinhongno Enpyung ku, Seoul 122 704, Republic of Korea
    Toxicol Lett 189:177-83. 2009
    ..Silica nanoparticles were trapped by macrophages in the spleen and liver and remained there until 4 weeks after the single injection...
  87. ncbi Coarse particles and mortality: evidence from a multi-city study in California
    B J Malig
    California Office of Environmental Health Hazard Assessment, Oakland, California 94612, USA
    Occup Environ Med 66:832-9. 2009
    ....
  88. ncbi Interaction of gold nanoparticles with common human blood proteins
    Silvia H De Paoli Lacerda
    Center for Biological Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    ACS Nano 4:365-79. 2010
    ..K, as well as the degree of cooperativity of particle--protein binding (Hill constant, n), depends on particle size and the native protein structure...
  89. pmc Preparation, characterization, and in vitro targeted delivery of folate-decorated paclitaxel-loaded bovine serum albumin nanoparticles
    Dongmei Zhao
    Key Laboratory of Forest Plant Ecology, Northeast Forestry University, Ministry of Education, Harbin, Heilongjiang, China
    Int J Nanomedicine 5:669-77. 2010
    ..3% and 27.2%, respectively. The amount of folate conjugation was 9.22 μg/mg of bovine serum albumin. The folate-decorated nanoparticles targeted a human prostate cancer cell line effectively...
  90. ncbi Association of oxidative stress and PON1 with LDL and HDL particle size in middle-aged subjects
    J Vekic
    Institute for Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
    Eur J Clin Invest 37:715-23. 2007
    ..This study investigates the connection between LDL and HDL particle heterogeneity and oxidative stress, antioxidative defence (AOD) and paraoxonase (PON1) status in a healthy middle-aged Serbian population...
  91. doi Self-nanoemulsifying drug delivery systems of tamoxifen citrate: design and optimization
    Yosra S R Elnaggar
    Department of Pharmaceutics, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt yosra
    Int J Pharm 380:133-41. 2009
    ..Realizing drug incorporation into an optimized nano-sized SNEDD system that encompasses a bioactive surfactant, our results proposed that the prepared system could be promising to improve oral efficacy of the tamoxifen citrate...
  92. ncbi Cytotoxicity and immunological response of gold and silver nanoparticles of different sizes
    Hung Jen Yen
    Department of Chemical Engineering, National Chung Hsing University, 250 Kuo Kuang Road, Taichung 402, Taiwan, R O C
    Small 5:1553-61. 2009
    ....
  93. ncbi Particle size of liposomes influences dermal delivery of substances into skin
    D D Verma
    Institut für Pharmazeutische Technologie und Biopharmazie, Philipps Universitat Marburg, Ketzerbach 63, 35037, Marburg, Germany
    Int J Pharm 258:141-51. 2003
    ..The results indicated that the CF penetration was inversely related to the size of the liposomes, which was confirmed by the data of the confocal laser scanning microscopy studies...
  94. ncbi Nanosuspensions: a promising drug delivery strategy
    V B Patravale
    Pharmaceutical Division, University Institute of Chemical Technology, Matunga, Mumbai 400 019, India
    J Pharm Pharmacol 56:827-40. 2004
    ..Rapid strides have been made in the delivery of nanosuspensions by parenteral, peroral, ocular and pulmonary routes. Currently, efforts are being directed to extending their applications in site-specific drug delivery...
  95. ncbi Pulmonary responses of mice, rats, and hamsters to subchronic inhalation of ultrafine titanium dioxide particles
    Edilberto Bermudez
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 77:347-57. 2004
    ..These differences can be explained both by pulmonary respy response and by particle dosimetry differences among these rodent species...
  96. ncbi Degradable polyethylenimine-alt-poly(ethylene glycol) copolymers as novel gene carriers
    Mi Ran Park
    School of Agricultural Biotechnology, Seoul National University, Seoul 151 742, Korea
    J Control Release 105:367-80. 2005
    ....
  97. ncbi Development of superparamagnetic nanoparticles for MRI: effect of particle size, charge and surface nature on biodistribution
    C Chouly
    Laboratoire de Biophysique, Faculte de Medecine, Angers, France
    J Microencapsul 13:245-55. 1996
    ..It was up to 3 X lower for electrically neutral particles than for charged particles. Coated particles presented higher vascular persistence. The diagnostic potential for liver, lymph node or vascular imaging were discussed...
  98. pmc The effects of components of fine particulate air pollution on mortality in california: results from CALFINE
    Bart Ostro
    Office of Environmental Health Hazard Assessment, 16th Floor, 1515 Clay St, Oakland, CA 94612, USA
    Environ Health Perspect 115:13-9. 2007
    ..5 pm in diameter (PM2.5). Little is known, however, about the relative effects of PM2.5 constituents. We examined associations between 19 PM2.5 components and daily mortality in six California counties...
  99. ncbi Nano/micro technologies for delivering macromolecular therapeutics using poly(D,L-lactide-co-glycolide) and its derivatives
    Raghavendra C Mundargi
    Industrial Biotechnology Group, Reliance Life Sciences Pvt Ltd, Dhirubhai Ambani Life Sciences Centre, Thane Belapur Road, Rabale, Navi Mumbai 400 701, India
    J Control Release 125:193-209. 2008
    ..Drug encapsulation, particle size, additives added during formulation, molecular weight, ratio of lactide to glycolide moieties in PLGA and ..
  100. pmc Role of target geometry in phagocytosis
    Julie A Champion
    Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA
    Proc Natl Acad Sci U S A 103:4930-4. 2006
    ..Failure to create the required actin structure results in simple spreading and not internalization. Particle size primarily impacts the completion of phagocytosis in cases where particle volume exceeds the cell volume.
  101. pmc Associations between air pollution and mortality in Phoenix, 1995-1997
    T F Mar
    Department of Environmental Health, University of Washington, Seattle, WA 98195 7234, USA
    Environ Health Perspect 108:347-53. 2000
    ..5), PM(10), PM(CF) (p < 0.05), and elemental carbon. Factor analysis revealed that both combustion-related pollutants and secondary aerosols (sulfates) were associated with cardiovascular mortality...

Research Grants78

  1. Pharmacogenetics of obesity and endocannabinergic modulation (POEM)
    Russell A Wilke; Fiscal Year: 2009
    ..to be associated with lipid levels in the original cohort will also be tested for association with lipoprotein particle size distribution in these 504 subjects...
  2. Genetic contributors to diabetes and dyslipidemia in African Americans
    Michele M Sale; Fiscal Year: 2010
    ..genetic contributors to lipoprotein subclasses in African Americans using the lipoprotein subclass profile (particle size and concentration for multiple subclasses of VLDL, LDL, and HDL) assessed by NMR at LipoScience, Inc...
  3. Pharmacogenetics of obesity and endocannabinergic modulation (POEM)
    Russell A Wilke; Fiscal Year: 2010
    ..to be associated with lipid levels in the original cohort will also be tested for association with lipoprotein particle size distribution in these 504 subjects...
  4. Genetic contributors to diabetes and dyslipidemia in African Americans
    Michele M Sale; Fiscal Year: 2010
    ..genetic contributors to lipoprotein subclasses in African Americans using the lipoprotein subclass profile (particle size and concentration for multiple subclasses of VLDL, LDL, and HDL) assessed by NMR at LipoScience, Inc...
  5. Genetic contributors to diabetes and dyslipidemia in African Americans
    Michele Sale; Fiscal Year: 2009
    ..genetic contributors to lipoprotein subclasses in African Americans using the lipoprotein subclass profile (particle size and concentration for multiple subclasses of VLDL, LDL, and HDL) assessed by NMR at LipoScience, Inc...
  6. Project 1: In vitro Studies: Correlate the physical and chemical characteristics
    David L Eaton; Fiscal Year: 2011
    ..multiple colors within a biological sample and their emission wavelengths can be continuously tuned by varying particle size and/or chemical composition...
  7. PHYSIOLOGY OF FLUOROCARBON OXYGEN TRANSPORT
    LELAND CLARK; Fiscal Year: 1992
    ..which it is dispersed in the blood, cardiac output, arterial oxygen and carbon dioxide tensions, fluorocarbon particle size, type of emulsifier used, acid-base balance, and other factors...
  8. PHYSIOLOGY OF FLUOROCARBON OXYGEN TRANSPORT
    LELAND CLARK; Fiscal Year: 1990
    ..which it is dispersed in the blood, cardiac output, arterial oxygen and carbon dioxide tensions, fluorocarbon particle size, type of emulsifier used, acid-base balance, and other factors...
  9. Development of Age-Appropriate Fast Disintegrating Pediatric Granules and Tablets
    MOJI ADEYEYE; Fiscal Year: 2009
    ..of the drug include powder X- Ray diffraction, differential scanning calorimetry, thermogravimetry and particle size analysis. These properties could affect the solubility, disintegration and dissolution of the final product...
  10. Pharmacogenetics of obesity and endocannabinergic modulation (POEM)
    RUSSELL WILKE; Fiscal Year: 2009
    ..to be associated with lipid levels in the original cohort will also be tested for association with lipoprotein particle size distribution in these 504 subjects...
  11. Nanopolymersomes for Transcutaneous Co-Delivery of Vaccine Antigens and Adjuvants
    PAUL CAMILLE TUMEH; Fiscal Year: 2011
    ..I will test NPSs varying in copolymer composition, particle size, deformability, and mechanical toughness to optimize this delivery system...
  12. Mosquito Vector Control Using Bt Coupled to Seed Oil Bodies
    Mohd Amir Abdullah; Fiscal Year: 2009
    ..Seeds will be milled into Bt-flour, with a particle size approximating that of food consumed by filter-feeding larvae...
  13. High Density Lipoprotein (HDL) in Follicular Fluid and Fertility Outcomes
    VICTOR YUTAKA FUJIMOTO; Fiscal Year: 2010
    ..cholesterol transport, anti-oxidant and anti-inflammatory activities of HDL are a function of the dynamic HDL particle size distributions and the complex HDL composition which includes lipids, apolipoproteins, micronutrients and ..
  14. Near-Infrared VCD of Chiral Pharmaceuticals
    Laurence Nafie; Fiscal Year: 2002
    ..The sensitivity of FT-near-IR VCD to particle size, moisture Content and aggregation in protein pharmaceuticals will be determined...
  15. Near-Infrared VCD of Chiral Pharmaceuticals
    Laurence Nafie; Fiscal Year: 2004
    ..The sensitivity of FT-near-IR VCD to particle size, moisture Content and aggregation in protein pharmaceuticals will be determined...
  16. Near-Infrared VCD of Chiral Pharmaceuticals
    Laurence Nafie; Fiscal Year: 2001
    ..The sensitivity of FT-near-IR VCD to particle size, moisture Content and aggregation in protein pharmaceuticals will be determined...
  17. Near-Infrared VCD of Chiral Pharmaceuticals
    Laurence Nafie; Fiscal Year: 2003
    ..The sensitivity of FT-near-IR VCD to particle size, moisture Content and aggregation in protein pharmaceuticals will be determined...
  18. Fully Biodegradable Polymersome-encapsulated Hemoglobin as a Novel Nanoparticle-b
    PAIMAN PETER GHOROGHCHIAN; Fiscal Year: 2010
    ..These dispersions will be rigorously characterized for particle size and morphology, hemoglobin encapsulation efficiency and methamoglobin (metHb) level, We will also characterize ..
  19. Role of Genes in Exceptional Longevity in Humans
    Nir Barzilai; Fiscal Year: 2009
    ..These lipoprotein particle size are lower in offspring that have age-related diseases...
  20. Role of Genes in Exceptional Longevity in Humans
    Nir Barzilai; Fiscal Year: 2007
    ..These lipoprotein particle size are lower in offspring that have age-related diseases...
  21. Inhaled Aminoglycoside Formulafor Plague and Tularemia
    James Talton; Fiscal Year: 2005
    ..objectives of this Project is to (1) compare steptomycin and gentamicin particle formulations measuring the particle size, aerosol properties, and cytotoxicity in pulmonary cell cultures in vitro and (2) compare inhaled ..
  22. Gold Nanoparticle Assisted Delivery of Cancer Vaccines and Immune Stimulants
    Adam Lin; Fiscal Year: 2012
    ..From preliminary characterizations of AuNVs, conjugation yield is very high (~90%) and the overall particle size remained sub-100nm. This will allow potential lymphatic drainage post subcutaneous injection...
  23. Mucus Penetrating Nanoparticles for Vaginal Drug Delivery
    Justin Hanes; Fiscal Year: 2009
    ..In Aim 1, we will fully characterize particle size and surface properties, and use particle tracking to observe diffusional transport rates of mucus-penetrating ..
  24. PHYSIOCHEMICAL EFFECTS OF DIETARY FIBER IN HUMANS
    JUDITH MARLETT; Fiscal Year: 1990
    ..each fiber will be determined by measuring bile acid binding, cation exchange and water holding capacities and particle size in vitro...
  25. RADIOPAQUE FLUOROCARBON IN DIAGNOSTIC RADIOLOGY
    David Long; Fiscal Year: 1980
    ..Preliminary studies show that small particle size emulsions radiopacify the entire cardiovascular system for several hours after injection...
  26. METABOLISM OF APO-E-RICH HDL BY HEPATIC LIPASE
    B Waite; Fiscal Year: 1993
    ..These particles provide carefully controlled composition to determine the effect of lipid composition, particle size, and apoprotein content on lipid hydrolysis by HL...
  27. INHALED PARTICLE CHARACTERISTICS AND EARLY LUNG EFFECTS
    William Beckett; Fiscal Year: 2001
    ..cadmium) causing COPD in the workplace have been characterized based on chemical composition and respirable particle size. These findings suggest that the much broader range of workplace dusts may in certain conditions contribute to ..
  28. INHALED PARTICLE CHARACTERISTICS AND EARLY LUNG EFFECTS
    William Beckett; Fiscal Year: 2000
    ..cadmium) causing COPD in the workplace have been characterized based on chemical composition and respirable particle size. These findings suggest that the much broader range of workplace dusts may in certain conditions contribute to ..
  29. INHALED PARTICLE CHARACTERISTICS AND EARLY LUNG EFFECTS
    William Beckett; Fiscal Year: 2002
    ..cadmium) causing COPD in the workplace have been characterized based on chemical composition and respirable particle size. These findings suggest that the much broader range of workplace dusts may in certain conditions contribute to ..
  30. CATIONIC LIPOSOME MEDIATED GENE THERAPY-CYSTIC FIBROSIS
    ROBERT DEBS; Fiscal Year: 1992
    ..element, B) cationic liposome formulation, C) DNA to liposome ratio, D) gene dosage and E) mean aerosol particle size and F) frequency/duration of administration...
  31. DEPOSITION OF VOLATILE AEROSOLS IN THE RESPIRATORY TRACT
    Sidney Soderholm; Fiscal Year: 1990
    ..physical properties of the airborne system, including exposure concentration, saturation vapor concentration, particle size, and blood/gas partition coefficient...
  32. Predictive Toxicological Paradigms to Establish Inhalation Toxicology Models
    Andre Nel; Fiscal Year: 2009
    ..We will also assess ROS production. The NM properties that will be assessed include particle size, size distribution, dispersibility, zeta-potential, TEM, XRD and BET analysis...
  33. Predictive Toxicological Paradigms to Establish Inhalation Toxicology Models
    ANDRE ELIAS NEL; Fiscal Year: 2010
    ..We will also assess ROS production. The NM properties that will be assessed include particle size, size distribution, dispersibility, zeta-potential, TEM, XRD and BET analysis...
  34. Predictive Toxicological Paradigms to Establish Inhalation Toxicology Models
    ANDRE ELIAS NEL; Fiscal Year: 2010
    ..We will also assess ROS production. The NM properties that will be assessed include particle size, size distribution, dispersibility, zeta-potential, TEM, XRD and BET analysis...
  35. TLR Ligand and Pesticide Exposure in Farms: Role in Atopic Immune Responses
    Atin Adhikari; Fiscal Year: 2010
    ..an inhalable sampler and a NIOSH-developed size- selective sampling system with two-stage cyclone (three particle size fractions: <1.0 5m, 1 - 1.8 5m, and >1...
  36. Asthma Treatment with a Novel Drug Aerosol Generator
    William Shen; Fiscal Year: 2004
    ..treatment because of (1) the difficulty in coordinating actuation and inspiration, (2) excessively large particle size of generated aerosols inadequate for delivery to therapeutically important small bronchioles, and (3) ..
  37. NUTRITION AND LIPOPROTEIN METABOLISM IN ATHEROSCLEROSIS
    Lawrence Rudel; Fiscal Year: 1999
    ..We will document the compositional changes and particle size differences in HDL, and we will measure the rates of HDL particle formation and clearance to learn if the ..
  38. Development of methods and models for nanoparticle toxicity screening: Applicatio
    Andre Nel; Fiscal Year: 2007
    ..b>Particle size, shape, surface area, charge, and chemical composition are important physical variables that could determine ..
  39. Development of methods and models for nanoparticle toxicity screening: Applicatio
    Andre Nel; Fiscal Year: 2006
    ..b>Particle size, shape, surface area, charge, and chemical composition are important physical variables that could determine ..
  40. NEW METHODS FOR EVAL OF ORGANIC DUST AEROSOLS
    Stephen Reynolds; Fiscal Year: 2006
    ..and HAM, will be compared to the gravimetric methods, and their performance characterized in response to particle size distributions determined using a Grimm...
  41. NEW METHODS FOR EVAL OF ORGANIC DUST AEROSOLS
    Stephen Reynolds; Fiscal Year: 2003
    ..and HAM, will be compared to the gravimetric methods, and their performance characterized in response to particle size distributions determined using a Grimm...
  42. NEW METHODS FOR EVAL OF ORGANIC DUST AEROSOLS
    Stephen Reynolds; Fiscal Year: 2005
    ..and HAM, will be compared to the gravimetric methods, and their performance characterized in response to particle size distributions determined using a Grimm...
  43. COCKROACH ALLERGENS--IMMUNOCHEMISTRY & ALLERGIC DISEASE
    Martin Chapman; Fiscal Year: 1993
    ..The proposed studies will investigate the sites of allergen accumulation in the home and the particle size and concentration of airborne allergen...
  44. NEW METHODS FOR EVAL OF ORGANIC DUST AEROSOLS
    Stephen Reynolds; Fiscal Year: 2002
    ..and HAM, will be compared to the gravimetric methods, and their performance characterized in response to particle size distributions determined using a Grimm...
  45. NEW METHODS FOR EVAL OF ORGANIC DUST AEROSOLS
    Stephen Reynolds; Fiscal Year: 2004
    ..and HAM, will be compared to the gravimetric methods, and their performance characterized in response to particle size distributions determined using a Grimm...
  46. BEHAVIORAL PHARMACOLOGY OF ABUSED AEROSOLS - 'CRACK'
    Ronald Wood; Fiscal Year: 1992
    ..6) demonstration of the feasibility of applying these techniques to methamphetamine HCI smoking...
  47. Precision Particle Fabrication-enabled Betamethasone-loaded Microspheres for Tran
    Milind Singh; Fiscal Year: 2012
    ..The central advantage of our approach is that PPF technology allows for precise control of particle size, shape, material, and release rates...
  48. Mechanisms of Influenza a Virus Transmission in Ferretts
    Daniel Perez; Fiscal Year: 2006
    ..We will determine the effect of particle size for efficient aerosol spread and the effect that virus morphology has to establish a natural chain of ..
  49. Mechanisms of Influenza a Virus Transmission in Ferretts
    Daniel Perez; Fiscal Year: 2007
    ..We will determine the effect of particle size for efficient aerosol spread and the effect that virus morphology has to establish a natural chain of ..
  50. Pulmonary Formulation of tPA for Plastic Bronchitis
    Kathleen A Stringer; Fiscal Year: 2010
    ..of pf-tPA to reduce fibrin cast mass;2) To demonstrate pediatric pulmonary delivery by acquiring aerodynamic particle size data to estimate lung distribution and respirable dose of nebulized pf-tPA...
  51. MECHANISM OF ATHEROGENIC LIPID RESPONSE TO W-3 FISH OILS
    Sidika Kasim Karakas; Fiscal Year: 1990
    ..This causes a reduction in the TG in very low density lipoproteins (VLDL) and an associated decrease in their particle size; which , together with a concurrent increase in lipoprotein lipase (LPL) activity, expedites the conversion of ..
  52. FAILURE MECHANISMS OF REVISION JOINT REPLACEMENT
    Joan Bechtold; Fiscal Year: 1999
    ..The study will proceed as follows: in Year 1, the study of the particle size on membrane and bone characteristics will be completed...
  53. FAILURE MECHANISMS OF REVISION JOINT REPLACEMENT
    Joan Bechtold; Fiscal Year: 2000
    ..The study will proceed as follows: in Year 1, the study of the particle size on membrane and bone characteristics will be completed...
  54. RESPIRATOR EFFICACY VERSUS TUBERCULOSIS AEROSOLS
    John Koerner; Fiscal Year: 2000
    ..that result from the aerosolization of solutions containing Mycobacterium tuberculosis; 2) to determine the particle size distribution and particle shapes characteristic of the aerosol generated by the cough of humans infectious ..
  55. RESPIRATOR EFFICACY VERSUS TUBERCULOSIS AEROSOLS
    John Koerner; Fiscal Year: 1999
    ..that result from the aerosolization of solutions containing Mycobacterium tuberculosis; 2) to determine the particle size distribution and particle shapes characteristic of the aerosol generated by the cough of humans infectious ..
  56. Mentored Patient-Oriented Research Career Development Award
    Michelle Zeidler; Fiscal Year: 2005
    ..the mainstay of asthma treatment, cannot effectively reach the distal lung due to their relatively large particle size. The recent transition to non-CFC inhalers has created a new class of extra-fine ICS aerosols which, ..
  57. Mentored Patient-Oriented Research Career Development Award
    Michelle Zeidler; Fiscal Year: 2006
    ..the mainstay of asthma treatment, cannot effectively reach the distal lung due to their relatively large particle size. The recent transition to non-CFC inhalers has created a new class of extra-fine ICS aerosols which, ..
  58. Extra-Fine Inhaled Corticosteroid Effect on Distal Lung Disease in Asthma
    Michelle Zeidler; Fiscal Year: 2007
    ..the mainstay of asthma treatment, cannot effectively reach the distal lung due to their relatively large particle size. The recent transition to non-CFC inhalers has created a new class of extra-fine ICS aerosols which, ..
  59. Mentored Patient-Oriented Research Career Development Award
    Michelle Zeidler; Fiscal Year: 2004
    ..the mainstay of asthma treatment, cannot effectively reach the distal lung due to their relatively large particle size. The recent transition to non-CFC inhalers has created a new class of extra-fine ICS aerosols which, ..
  60. Mentored Patient-Oriented Research Career Development Award
    Michelle Zeidler; Fiscal Year: 2003
    ..the mainstay of asthma treatment, cannot effectively reach the distal lung due to their relatively large particle size. The recent transition to non-CFC inhalers has created a new class of extra-fine ICS aerosols which, ..
  61. Cardiovascular Consequences of Thyroid Dysfunction
    Elizabeth Pearce; Fiscal Year: 2003
    ..overall hypothesis of this proposal is that abnormal thyroid function is associated with alterations in lipid particle size, in endothelial reactivity, and in cardiac contractility, which result in increased risk for adverse clinical ..
  62. Cardiovascular Consequences of Thyroid Dysfunction
    Elizabeth Pearce; Fiscal Year: 2006
    ..overall hypothesis of this proposal is that abnormal thyroid function is associated with alterations in lipid particle size, in endothelial reactivity, and in cardiac contractility, which result in increased risk for adverse clinical ..
  63. COAL DUST PARTICLE SIZE AND RESPIRATORY DISEASE
    Thomas Robins; Fiscal Year: 1990
    The proposed research will explore the importance of particle size fractions and temporal aspects of exposure to coal mine dust to the development of chronic bronchitis and airways obstruction in underground coal miners...
  64. ACTION OF ALCOHOL/QUERCETIN ON ANTI-ATHEROGENIC FACTOR
    Raj Lakshman; Fiscal Year: 2006
    ..of quercetin and/or ethanol on AAA factors (PON status, HDL's capacity to inhibit LDL oxidation, LDL particle size, and OxLDL level in aorta) with the extent of atherosclerosis in the aorta (morphometric analysis of aorta) in ..
  65. Cardiovascular Consequences of Thyroid Dysfunction
    Elizabeth Pearce; Fiscal Year: 2004
    ..overall hypothesis of this proposal is that abnormal thyroid function is associated with alterations in lipid particle size, in endothelial reactivity, and in cardiac contractility, which result in increased risk for adverse clinical ..
  66. Cardiovascular Consequences of Thyroid Dysfunction
    Elizabeth Pearce; Fiscal Year: 2007
    ..overall hypothesis of this proposal is that abnormal thyroid function is associated with alterations in lipid particle size, in endothelial reactivity, and in cardiac contractility, which result in increased risk for adverse clinical ..
  67. Nanocrystalline Phosphors for Medical Imaging Applications
    CHRISTOPHER SUMMERS; Fiscal Year: 2009
    ..Although phosphor screens made from micron-sized phosphors are efficient, bright X-ray converters, their large particle size produces a great deal of scatter, which limits their spatial resolution...
  68. INHALED AEROSOLS: CHARACTERISTICS AND RETENTION
    F Hiller; Fiscal Year: 1980
    ..aerodynamic size distribution of commonly used therapeutic aerosols and to determine the effect of humidity on particle size. We have also done preliminary studies of retention of therapeutic aerosols and of the size distribution of ..
  69. ACTION OF ALCOHOL & QUERCETIN ON ANTI-ATHEROGENIC FACTORS & ATHEROGENESIS
    Raj Lakshman; Fiscal Year: 2007
    ..of quercetin and/or ethanol on AAA factors (PON status, HDL's capacity to inhibit LDL oxidation, LDL particle size, and OxLDL level in aorta) with the extent of atherosclerosis in the aorta (morphometric analysis of aorta) in ..
  70. Cardiovascular Consequences of Thyroid Dysfunction
    Elizabeth Pearce; Fiscal Year: 2005
    ..overall hypothesis of this proposal is that abnormal thyroid function is associated with alterations in lipid particle size, in endothelial reactivity, and in cardiac contractility, which result in increased risk for adverse clinical ..
  71. Nanoengineered HIV-1 Vaccines Based on Tat
    RUSSELL MUMPER; Fiscal Year: 2003
    ..be coated on both types of nanoparticles, and iii) characterize the nanoparticle-based vaccines in terms of particle size, surface charge, stability, and cell uptake and/or transfection in human dendritic cells...
  72. Nanoengineered HIV-1 Vaccines Based on Tat
    RUSSELL MUMPER; Fiscal Year: 2004
    ..be coated on both types of nanoparticles, and iii) characterize the nanoparticle-based vaccines in terms of particle size, surface charge, stability, and cell uptake and/or transfection in human dendritic cells...