- Toxic potential of materials at the nanolevel
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
Science 311:622-7. 2006
..The establishment of principles and test procedures to ensure safe manufacture and use of nanomaterials in the marketplace is urgently required and achievable...
- Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology
Marie Christine Daniel
Molecular Nanosciences and Catalysis Group, LCOO, UMR CNRS No 5802, Universite Bordeaux I, 33405 Talence Cedex, France
Chem Rev 104:293-346. 2004
- Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications
Ajay Kumar Gupta
Crusade Laboratories Limited, Southern General Hospital, 1345 Govan Road, Glasgow G51 4TF, Scotland, UK
Biomaterials 26:3995-4021. 2005
..that these nanoparticles have high magnetization values and size smaller than 100 nm with overall narrow particle size distribution, so that the particles have uniform physical and chemical properties...
- Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells
B Devika Chithrani
Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada
Nano Lett 6:662-8. 2006
..g., tuning intracellular delivery rates and amounts by nanoscale dimensions and engineering complex, multifunctional nanostructures for imaging and therapeutics)...
- Elucidating the mechanism of cellular uptake and removal of protein-coated gold nanoparticles of different sizes and shapes
B Devika Chithrani
Institute of Biomaterials and Biomedical Engineering, Terrence Donnelly Center for Cellular and Biomolecular Research, University of Toronto, 160 College Street, 4th Floor, Toronto, Ontario M5S 3G9, Canada
Nano Lett 7:1542-50. 2007
..These studies will provide guidelines for developing NPs for imaging and drug delivery applications, which will require "controlling" NP accumulation rate. These studies will also have implications in determining nanotoxicity...
- Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles
Department of Environmental Medicine, University of Rochester, Rochester, New York 14642, USA
Environ Health Perspect 113:823-39. 2005
..An interdisciplinary team approach (e.g., toxicology, materials science, medicine, molecular biology, and bioinformatics, to name a few) is mandatory for nanotoxicology research to arrive at an appropriate risk assessment...
- Understanding biophysicochemical interactions at the nano-bio interface
Andre E Nel
Division of NanoMedicine, David Geffen School of Medicine and California NanoSystems Institute at UCLA, Los Angeles, California 90095, USA
Nat Mater 8:543-57. 2009
..This knowledge is important from the perspective of safe use of nanomaterials...
- Effect of surface properties on nanoparticle-cell interactions
Department of Materials Science and Engineering, Massachusetts Institute of Technology MIT, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
Small 6:12-21. 2010
..Challenges for undertaking a systematic study to elucidate nanoparticle-cell interactions are also discussed...
- Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis
Department of Membrane Cell Biology, University of Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
Biochem J 377:159-69. 2004
..In the present study, we have investigated the effect of particle size on the pathway of entry and subsequent intracellular fate in non-phagocytic B16 cells, using a range of ..
- Understanding the nanoparticle-protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles
School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland
Proc Natl Acad Sci U S A 104:2050-5. 2007
..The kinetic and equilibrium binding properties depend on protein identity as well as particle surface characteristics and size...
- Strategies in the design of nanoparticles for therapeutic applications
Robby A Petros
Department of Chemistry, University of North Texas, Denton, Texas 76203, USA
Nat Rev Drug Discov 9:615-27. 2010
..This Review focuses on recent progress important for the rational design of such nanoparticles and discusses the challenges to realizing the potential of nanoparticles...
- Size-dependent cytotoxicity of gold nanoparticles
Biomedical Engineering, Biointerface Laboratory, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany
Small 3:1941-9. 2007
..The cellular response is size dependent, in that 1.4-nm particles cause predominantly rapid cell death by necrosis within 12 h while closely related particles 1.2 nm in diameter effect predominantly programmed cell death by apoptosis...
- PVP-coated silver nanoparticles and silver ions induce reactive oxygen species, apoptosis and necrosis in THP-1 monocytes
Department of Environmental and Occupational Medicine, Institute of Public Health, Aarhus University, Bartholins Alle 2, Bygn 1260, 8000 Aarhus, Denmark
Toxicol Lett 190:156-62. 2009
..A drastic increase in ROS levels could be detected after 6-24h suggesting that oxidative stress is an important mediator of cytotoxicity caused by Ag NPs and Ag+...
- Calculated absorption and scattering properties of gold nanoparticles of different size, shape, and composition: applications in biological imaging and biomedicine
Prashant K Jain
Laser Dynamics Laboratory, School of Chemistry and Biochemistry, Georgia, Institute of Technology, Atlanta, Georgia 30332 0400, USA
J Phys Chem B 110:7238-48. 2006
- Factors affecting the clearance and biodistribution of polymeric nanoparticles
Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Mol Pharm 5:505-15. 2008
- Renal clearance of quantum dots
Hak Soo Choi
Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Room SL B05, Boston, Massachusetts 02215, USA
Nat Biotechnol 25:1165-70. 2007
..5 nm resulted in rapid and efficient urinary excretion and elimination of quantum dots from the body. This study provides a foundation for the design and development of biologically targeted nanoparticles for biomedical applications...
- A toxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors
Nicholas School of the Environment and Earth Sciences, Duke University, Durham, North Carolina 27708, USA
Environ Health Perspect 114:165-72. 2006
..Key words: environment, human health, nanomaterials, nanosized particles, nanotechnology, nanotoxicology, quantum dots, toxicology...
- Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration
Laboratory for Bio Environmental Effects of Nanomaterials and Nanosafety and Key Laboratory of Nuclear Analytical Techniques, National Center for NanoScience and Technology and Institute of High Energy Physics, Beijing 100080, PR China
Toxicol Lett 168:176-85. 2007
..Biodistribution experiment showed that TiO(2) mainly retained in the liver, spleen, kidneys, and lung tissues, which indicated that TiO(2) particles could be transported to other tissues and organs after uptake by gastrointestinal tract...
- Curcumin and its nano-formulation: the kinetics of tissue distribution and blood-brain barrier penetration
Yin Meng Tsai
Institute of Traditional Medicine, National Yang Ming University, Taipei, Taiwan
Int J Pharm 416:331-8. 2011
..The mean particle size and entrapment efficiency were 163nm and 46.9%, respectively...
- Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles
State Key Laboratory of Genetic Engineering, Department of Pharmaceutical Sciences, School of Life Sciences, Fudan University, Shanghai 200433, China
Biomaterials 31:3657-66. 2010
To elucidate the effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles (NPs), rhodamine B (RhB) labeled carboxymethyl chitosan grafted NPs (RhB-CMCNP) and chitosan hydrochloride ..
- Particle size-dependent organ distribution of gold nanoparticles after intravenous administration
Wim H De Jong
Laboratory for Health Protection Research, National Institute for Public Health and the Environment RIVM, Antonie van Leeuwenhoeklaan 9, Bilthoven, The Netherlands
Biomaterials 29:1912-9. 2008
A kinetic study was performed to determine the influence of particle size on the in vivo tissue distribution of spherical-shaped gold nanoparticles in the rat...
- Asbestos, carbon nanotubes and the pleural mesothelium: a review of the hypothesis regarding the role of long fibre retention in the parietal pleura, inflammation and mesothelioma
University of Edinburgh, Centre for Inflammation Research, Queens Medical Research Institute, 47 Little France Crescent, Edinburgh EH164TJ, UK
Part Fibre Toxicol 7:5. 2010
- Silver nanoparticles as a new generation of antimicrobials
Department of Biotechnology, SGB Amravati University, Amravati 444 602, Maharashtra, India
Biotechnol Adv 27:76-83. 2009
..Hence, silver nanoparticles have emerged up with diverse medical applications ranging from silver based dressings, silver coated medicinal devices, such as nanogels, nanolotions, etc...
- Solid lipid nanoparticles: production, characterization and applications
Institute of Pharmacy, Department of Pharmaceutical Technology, Free University of Berlin, Kelchstr 31, D 12169, Berlin, Germany
Adv Drug Deliv Rev 47:165-96. 2001
..The use of several analytical techniques is a necessity. Alternative structures and dynamic phenomena on the molecular level have to be considered. Aspects of SLN administration and the in vivo fate of the carrier are discussed...
- Stability and aggregation of metal oxide nanoparticles in natural aqueous matrices
Arturo A Keller
University of California, Santa Barbara, USA
Environ Sci Technol 44:1962-7. 2010
..8 microm s(-1) V(-1) cm. These results are key for designing and interpreting nanoparticle ecotoxicity studies in various environmental conditions...
- Cytotoxicity of nanoparticles independent from oxidative stress
Center for Medical Research, Medical University of Graz, A 8010 Graz, Austria
J Toxicol Sci 34:363-75. 2009
..Protein containing solutions led to increases in particle size, decreased cytotoxicity and reduced cellular uptake...
- Nanomedicine: current status and future prospects
S Moein Moghimi
Molecular Targeting and Polymer Toxicology Group, School of Pharmacy, University of Brighton, Brighton, UK
FASEB J 19:311-30. 2005
..Potential pitfalls or side effects associated with nanoparticles are also discussed...
- Cellular responses induced by silver nanoparticles: In vitro studies
Centre for Nanobioscience, Agharkar Research Institute, G G Agarkar Road, Pune 411004, India
Toxicol Lett 179:93-100. 2008
..5 microg/mL in both cell types). These results can be used to define a safe range of SNP for the intended application as a topical antimicrobial agent after appropriate in vivo studies...
- Preparation and evaluation of self-microemulsifying drug delivery system of oridonin
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 210203, PR China
Int J Pharm 355:269-76. 2008
..The absorption of oridonin from SMEDDS showed a 2.2-fold increase in relative bioavailability compared with that of the suspension. Our studies demonstrated the promising use of SMEDDS for the delivery of oridonin by the oral route...
- Recent advances in iron oxide nanocrystal technology for medical imaging
Guerbet Research, BP 57400, 95943 Roissy CDG, France
Adv Drug Deliv Rev 58:1471-504. 2006
..Stem cell migration and immune cell trafficking, as well as targeted iron oxide nanoparticles for molecular imaging studies, are at the stage of proof of concept, mainly in animal models...
- Uptake and intracellular fate of surface-modified gold nanoparticles
Department of Chemistry, University of Liverpool, Liverpool, United Kingdom
ACS Nano 2:1639-44. 2008
..Successful nuclear targeting is demonstrated using surface modification with a cocktail of CPPs and a peptide acting as a nuclear localization signal (NLS)...
- Nanoparticle-mediated cellular response is size-dependent
Nat Nanotechnol 3:145-50. 2008
..The findings presented here may assist in the design of nanoscale delivery and therapeutic systems and provide insights into nanotoxicity...
- Surface-structure-regulated cell-membrane penetration by monolayer-protected nanoparticles
Department of Materials Science and Engineering, MIT, Massachusetts 02139, USA
Nat Mater 7:588-95. 2008
..Our results offer a paradigm for analysing the fundamental problem of cell-membrane-penetrating bio- and macro-molecules...
- Characterization of nanoparticle uptake by endothelial cells
Department of Pharmaceutical Sciences, College of Pharmacy, 986025 Nebraska Medical Center, Omaha, NE 68198 6025, USA
Int J Pharm 233:51-9. 2002
..Nanoparticles localized in the endothelium could provide prolonged drug effects because of their sustained release characterics, and also could protect the encapsulated agent from enzymatic degradation...
- Silver colloid nanoparticles: synthesis, characterization, and their antibacterial activity
Department of Physical Chemistry, Palacky University, Svobody 26, 771 46 Olomouc, Czech Republic
J Phys Chem B 110:16248-53. 2006
..Antibacterial activity of silver nanoparticles was found to be dependent on the size of silver particles. A very low concentration of silver (as low as 1.69 mug/mL Ag) gave antibacterial performance...
- Unique cellular interaction of silver nanoparticles: size-dependent generation of reactive oxygen species
Applied Biotechnology Branch, Human Effectiveness Directorate, Wright Patterson Air Force Base, Dayton, Ohio 45433, USA
J Phys Chem B 112:13608-19. 2008
..In summary, a size-dependent toxicity was produced by silver nanoparticles, and one predominant mechanism of toxicity was found to be largely mediated through oxidative stress...
- Evaluating the uptake and intracellular fate of polystyrene nanoparticles by primary and hepatocyte cell lines in vitro
Helinor J Johnston
Biomedicine and Sport and Exercise Science Research Group, School of Life Sciences, Edinburgh Napier University, Edinburgh EH10 5DT, UK
Toxicol Appl Pharmacol 242:66-78. 2010
..The findings were, in the main, comparable between primary rat hepatocytes and the different human hepatocyte cell lines...
- Endocytosis at the nanoscale
The Krebs Institute, The Centre for Membrane Interaction and Dynamics, The Sheffield Cancer Research Centre, and the Department of Biomedical Science, The University of Sheffield, Western Bank, Sheffield, S10 2TN, UK
Chem Soc Rev 41:2718-39. 2012
..Finally, we discuss different drug delivery strategies on how to evade lysosomal degradation to promote effective release of the cargo (376 references)...
- Surface-modified superparamagnetic nanoparticles for drug delivery: preparation, characterization, and cytotoxicity studies
Ajay Kumar Gupta
Centre for Cell Engineering, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
IEEE Trans Nanobioscience 3:66-73. 2004
- A high-performance nanobio photocatalyst for targeted brain cancer therapy
Elena A Rozhkova
The Center for Nanoscale Materials, Argonne National Laboratory, Argonne, Illinois 60439, USA
Nano Lett 9:3337-42. 2009
..Synchrotron X-ray fluorescence microscopy (XFM) was applied for direct visualization of the nanobioconjugate distribution through a single brain cancer cell at the submicrometer scale...
- The effect of particle design on cellular internalization pathways
Stephanie E A Gratton
Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599, USA
Proc Natl Acad Sci U S A 105:11613-8. 2008
The interaction of particles with cells is known to be strongly influenced by particle size, but little is known about the interdependent role that size, shape, and surface chemistry have on cellular internalization and intracellular ..
- Residual polyvinyl alcohol associated with poly (D,L-lactide-co-glycolide) nanoparticles affects their physical properties and cellular uptake
Sanjeeb K Sahoo
Department of Pharmaceutical Sciences, University of Nebraska Medical Center 986025, Omaha, NE 68198 6025, USA
J Control Release 82:105-14. 2002
..The residual PVA, in turn, influenced different pharmaceutical properties of nanoparticles such as particle size, zeta potential, polydispersity index, surface hydrophobicity, protein loading and also slightly influenced ..
- The effect of sedimentation and diffusion on cellular uptake of gold nanoparticles
Eun Chul Cho
Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
Nat Nanotechnol 6:385-91. 2011
..Our results suggest that sedimentation needs to be considered when performing in vitro studies for large and/or heavy nanoparticles...
- Cellular uptake, cytotoxicity, and innate immune response of silica-titania hollow nanoparticles based on size and surface functionality
Wan Kyu Oh
School of Chemical and Biological Engineering, Seoul National University, 599 Gwanangro, Gwanak Gu, Seoul 151 742, Korea
ACS Nano 4:5301-13. 2010
..These findings provide size- and surface functionality-dependent nanotoxicity and uptake of HNPs, and lead to HNPs for bioapplications such as drug delivery and imaging probe...
- Characterization of nanomaterial dispersion in solution prior to in vitro exposure using dynamic light scattering technique
Richard C Murdock
Applied Biotechnology Branch, Human Effectiveness Directorate Air Force Research Laboratory HEPB, Wright Patterson Air Force Board, Ohio 45433, USA
Toxicol Sci 101:239-53. 2008
The need to characterize nanoparticles in solution before assessing the in vitro toxicity is a high priority. Particle size, size distribution, particle morphology, particle composition, surface area, surface chemistry, and particle ..
- Time-series analysis of mortality effects of fine particulate matter components in Detroit and Seattle
New York University School of Medicine, Tuxedo, New York 10987, USA
Environ Health Perspect 119:461-6. 2011
..Recent toxicological and epidemiological studies have shown associations between particulate matter (PM) and adverse health effects, but which PM components are most influential is less well known...
- Silica and titanium dioxide nanoparticles cause pregnancy complications in mice
Department of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565 0871, Japan
Nat Nanotechnol 6:321-8. 2011
..These detrimental effects are linked to structural and functional abnormalities in the placenta on the maternal side, and are abolished when the surfaces of the silica nanoparticles are modified with carboxyl and amine groups...
- Optimization and characterization of anionic lipoplexes for gene delivery
Department of Pharmaceutical Sciences, University of Connecticut, 69 North Eagleville Road, Unit 3092, Storrs, CT 06269, USA
J Control Release 136:62-70. 2009
..8 microg plasmid DNA. Biophysical studies (particle size analysis, gel electrophoresis, transmission electron microscopy (TEM), and confocal microscopy) were conducted ..
- The kinetics of the tissue distribution of silver nanoparticles of different sizes
D P K Lankveld
Laboratory for Health Protection Research, National Institute for Public Health and the Environment RIVM, PO Box 1, 3720 BA Bilthoven, The Netherlands
Biomaterials 31:8350-61. 2010
..Model parameter values were estimated by fitting to data. No clear relation between parameter values and corresponding particle diameters became apparent...
- Translocation of inhaled ultrafine particles to the brain
Department of Environmental Medicine, University of Rochester, Rochester, New York 14642, USA
Inhal Toxicol 16:437-45. 2004
..Depending on their particle size, inhaled UFP are efficiently deposited in nasal, tracheobronchial, and alveolar regions due to diffusion...
- Biodistribution of colloidal gold nanoparticles after intravenous administration: effect of particle size
Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, Japan
Colloids Surf B Biointerfaces 66:274-80. 2008
..Another objective was to study effect of particle size on biological distribution of gold NP to enable their diverse applications in nanotechnology...
- Spatial and temporal variation in PM(2.5) chemical composition in the United States for health effects studies
Michelle L Bell
School of Forestry and Environmental Studies, Yale University, New Haven, Connecticut, USA
Environ Health Perspect 115:989-95. 2007
..Although numerous studies have demonstrated links between particulate matter (PM) and adverse health effects, the chemical components of the PM mixture that cause injury are unknown...
- Large porous particles for pulmonary drug delivery
D A Edwards
Department of Chemical Engineering, Pennsylvania State University, 204 Fenske Laboratory, University Park, PA 16802, USA
Science 276:1868-71. 1997
..High systemic bioavailability of testosterone was also achieved by inhalation delivery of porous particles with a mean diameter (20 micrometers) approximately 10 times that of conventional inhaled therapeutic particles...
- Oxide nanoparticle uptake in human lung fibroblasts: effects of particle size, agglomeration, and diffusion at low concentrations
Ludwig K Limbach
Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zurich, Switzerland
Environ Sci Technol 39:9370-6. 2005
..but physiologically relevant concentrations reveal a strong dependence of the amount of incorporated ceria on particle size, while nanoparticle number density or total particle surface area are of minor importance...
- Mechanics of receptor-mediated endocytosis
Max Planck Institute for Metals Research, Heisenbergstrasse 3, D 70569 Stuttgart, Germany
Proc Natl Acad Sci U S A 102:9469-74. 2005
..This model can also be extended to include the effect of clathrin coat. The results seem to show broad agreement with experimental observations...
- Effects of prenatal exposure to surface-coated nanosized titanium dioxide (UV-Titan). A study in mice
Karin S Hougaard
National Research Centre for the Working Environment, Copenhagen Ø, Denmark
Part Fibre Toxicol 7:16. 2010
..Consequently, also toxicological properties may change compared to the parent compound. We examined developmental and neurobehavioral effects following maternal exposure to a nanoparticulate UV-filter (UV-titan L181)...
- Mediating tumor targeting efficiency of nanoparticles through design
Steven D Perrault
Institute of Biomaterials and Biomedical Engineering, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, ON, M5S 3E1, Canada
Nano Lett 9:1909-15. 2009
..Our results provide design parameters for engineering nanoparticles for optimized tumor targeting of contrast agents and therapeutics...
- Fine particulate matter constituents associated with cardiovascular hospitalizations and mortality in New York City
New York University School of Medicine, Tuxedo, New York 10987, USA
Environ Health Perspect 119:467-73. 2011
..We investigated this issue in New York City (NYC), where PM originates from regional and local combustion sources...
- In vitro toxicity of silica nanoparticles in human lung cancer cells
Department of Chemistry and Environmental Research Center, University of Missouri Rolla, Rolla, MO 65409, USA
Toxicol Appl Pharmacol 217:252-9. 2006
..In summary, exposure to SiO(2) nanoparticles results in a dose-dependent cytotoxicity in cultural human bronchoalveolar carcinoma-derived cells that is closely correlated to increased oxidative stress...
- Particle size, surface coating, and PEGylation influence the biodistribution of quantum dots in living mice
Meike L Schipper
Molecular Imaging Program at Stanford MIPS, Department of Radiology, Bio X Program, Stanford University, 318 Campus Drive, Palo Alto, CA 94305 5427, USA
Small 5:126-34. 2009
This study evaluates the influence of particle size, PEGylation, and surface coating on the quantitative biodistribution of near-infrared-emitting quantum dots (QDs) in mice...
- Nanocarriers' entry into the cell: relevance to drug delivery
School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA
Cell Mol Life Sci 66:2873-96. 2009
..Nevertheless, various strategies are being actively investigated in order to tailor nanocarriers able to deliver anticancer agents, nucleic acids, proteins and peptides for therapeutic applications by these non-phagocytic routes...
- Paclitaxel-loaded PEGylated PLGA-based nanoparticles: in vitro and in vivo evaluation
Universite Catholique de Louvain, Unite de Pharmacie Galenique, Avenue Mounier, 73 20, 1200 Brussels, Belgium
J Control Release 133:11-7. 2009
..Therefore, PTX-loaded nanoparticles may be considered as an effective anticancer drug delivery system for cancer chemotherapy...
- The effect of fine and coarse particulate air pollution on mortality: a national analysis
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
Environ Health Perspect 117:898-903. 2009
..5) and PM coarse on the increased risk of death for all causes, cardiovascular disease (CVD), myocardial infarction (MI), stroke, and respiratory mortality for the years 1999-2005...
- Protein adsorption and cellular uptake of cerium oxide nanoparticles as a function of zeta potential
Advanced Materials Processing and Analysis Center, Department of Mechanical, Materials and Aerospace Engineering, University of Central Florida, Orlando, FL 32816, USA
Biomaterials 28:4600-7. 2007
..These results demonstrate that electrostatic interactions can play an important factor in protein adsorption and cellular uptake of nanoparticles...
- Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size
Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Hongo, Bunkyo ku, Japan
Nat Nanotechnol 6:815-23. 2011
..We also showed that the penetration and efficacy of the larger micelles could be enhanced by using a transforming growth factor-β inhibitor to increase the permeability of the tumours...
- Influence of apolipoprotein (Apo) A-I structure on nascent high density lipoprotein (HDL) particle size distribution
Lipid Research Group, Gastroenterology, Hepatology, and Nutrition Division, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4318, USA
J Biol Chem 285:31965-73. 2010
..The stability of the apoA-I N-terminal helix bundle domain and the hydrophobicity of the C-terminal domain are important determinants of both nascent HDL particle size and their rate of formation.
- Ceramic-based nanoparticles entrapping water-insoluble photosensitizing anticancer drugs: a novel drug-carrier system for photodynamic therapy
Institute of Lasers, Photonics and Biophotonics, Department of Chemistry, State University of New York, Buffalo, NY 14260 3000, USA
J Am Chem Soc 125:7860-5. 2003
..Significant damage to such impregnated tumor cells was observed upon irradiation with light of wavelength 650 nm. Thus, the potential of using ceramic-based nanoparticles as drug carriers for photodynamic therapy has been demonstrated...
- Size-dependency of nanoparticle-mediated gene transfection: studies with fractionated nanoparticles
Department of Pharmaceutical Sciences, 986025 University of Nebraska Medical Center, Omaha, NE 68198 6025, USA
Int J Pharm 244:105-15. 2002
..The results suggest that the particle size is an important factor, and that the smaller-sized fraction of the nanoparticle formulation predominantly ..
- The impact of polycyclic aromatic hydrocarbons and fine particles on pregnancy outcome
Laboratory of Genetic Ecotoxicology, Regional Institute of Hygiene of Central Bohemia and Institute of Experimental Medicine, Academy of Science of the Czech Republic, Prague, Czech Republic
Environ Health Perspect 108:1159-64. 2000
..The results prove that exposure to c-PAHs in early gestation may influence fetal growth. The particulate matter-IUGR association observed earlier may be at least partly explained by the presence of c-PAHs on particle surfaces...
- Human serum albumin nanoparticles as an efficient noscapine drug delivery system for potential use in breast cancer: preparation and in vitro analysis
Biomedical Technology and Cell Therapy Research Laboratory, Department of Biomedical Engineering, Faculty of Medicine, McGill University, Montreal, Quebec, Canada
Int J Nanomedicine 5:525-32. 2010
..The nanoparticles were designed and optimized to achieve a particle size in the range of 150-300 nm with a drug-loading efficiency of 85%-96%...
- Chronic fine and coarse particulate exposure, mortality, and coronary heart disease in the Nurses' Health Study
ROBIN C PUETT
South Carolina Cancer Prevention and Control Program and Department of Epidemiology, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina 29201, USA
Environ Health Perspect 117:1697-701. 2009
..5 and 10 microm (PM(10-2.5)), may also be important. With respect to mortality and cardiovascular events, questions remain regarding the relative strength of effect sizes for chronic exposure to fine and coarse particles...
- Ambient air pollution and low birth weight in Connecticut and Massachusetts
Michelle L Bell
School of Forestry and Environmental Studies, Yale University, New Haven, Connecticut 06511, USA
Environ Health Perspect 115:1118-24. 2007
..Several studies have examined whether air pollution affects birth weight; however results vary and many studies were focused on Southern California or were conducted outside of the United States...
- The use of hypromellose in oral drug delivery
Chi L Li
GlaxoSmithKline Pharmaceuticals, Pharmaceutical Development, New Frontiers Science Park South, Third Avenue, Harlow, Essex, CM19 5AW, UK
J Pharm Pharmacol 57:533-46. 2005
- Woodsmoke health effects: a review
Luke P Naeher
Department of Environmental Health Science, College of Public Health, University of Georgia, Athens, Georgia, USA
Inhal Toxicol 19:67-106. 2007
..In addition, we provide recommendations for additional woodsmoke research...
- Circulating microparticles: pathophysiology and clinical implications
Irish Blood Transfusion Service, James s Street, Dublin 8, Ireland
Blood Rev 21:157-71. 2007
..In addition the complex role of microparticles in vascular and cardiovascular diseases is an area of immense interest, that promises to yield important advances into diagnosis and therapy...
- Copper oxide nanoparticles are highly toxic: a comparison between metal oxide nanoparticles and carbon nanotubes
Hanna L Karlsson
Department of Biosciences and Nutrition at Novum, Karolinska Institutet, Stockholm, Sweden
Chem Res Toxicol 21:1726-32. 2008
..The effects were not explained by soluble metal impurities. In conclusion, this study highlights the in vitro toxicity of CuO nanoparticles...
- Health effects of fine particulate air pollution: lines that connect
C Arden Pope
Department of Economics, Brigham Young University, Provo, UT 84602 2363, USA
J Air Waste Manag Assoc 56:709-42. 2006
- Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution
C Arden Pope
Department of Economics, Brigham Young University, 142 FOB, Provo, UT 84602, USA
JAMA 287:1132-41. 2002
..However, studies of health effects of long-term particulate air pollution have been less conclusive...
- A review of the in vivo and in vitro toxicity of silver and gold particulates: particle attributes and biological mechanisms responsible for the observed toxicity
Helinor J Johnston
Centre for Nano Safety, School of Life Sciences, Edinburgh Napier University, Edinburgh, UK
Crit Rev Toxicol 40:328-46. 2010
..Alternatively, a combination of both may be responsible, as the release of ions would be expected to be greater for smaller particles...
- A review of carbon nanotube toxicity and assessment of potential occupational and environmental health risks
Chiu wing Lam
JSC Toxicology Group, Space Life Sciences, NASA Johnson Space Center, Wyle Laboratories and Department of Pathology and Laboratory Medicine, University of Texas Medical School, Houston, Texas 77058, USA
Crit Rev Toxicol 36:189-217. 2006
..Therefore, CNTs from manufactured and combustion sources in the environment could have adverse effects on human health...
- Gastrointestinal persorption and tissue distribution of differently sized colloidal gold nanoparticles
J F Hillyer
Department of Animal Health and Biomedical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 1656 Linden Drive, Madison, Wisconsin 53706, USA
J Pharm Sci 90:1927-36. 2001
..In our quantitative studies we found that colloidal gold uptake is dependent on particle size: smaller particles cross the gastrointestinal tract more readily...
- Gold nanoparticles administration induced prominent inflammatory, central vein intima disruption, fatty change and Kupffer cells hyperplasia
Mohamed Anwar K Abdelhalim
Department of Physics and Astronomy, College of Science, King Saud University, Saudi Arabia
Lipids Health Dis 10:133. 2011
- Size-dependent proinflammatory effects of ultrafine polystyrene particles: a role for surface area and oxidative stress in the enhanced activity of ultrafines
D M Brown
School of Life Sciences, Napier University, 10 Colinton Road, Edinburgh EH10 5DT, Scotland
Toxicol Appl Pharmacol 175:191-9. 2001
..the effects of ultrafine particles in the lung have shown adverse effects considered to be due in part to the particle size. Air pollution particles (PM(10)) are associated with exacerbations of respiratory disease and deaths from ..
- Low molecular weight chitosan nanoparticles as new carriers for nasal vaccine delivery in mice
Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, Santiago de Compostela, Spain
Eur J Pharm Biopharm 57:123-31. 2004
..Furthermore, the response was not influenced by the CS dose (70-200 microg), achieving a significant response for a very low CS dose. In conclusion, nanoparticles made of low Mw CS are promising carriers for nasal vaccine delivery...
- Impact of silver nanoparticles on human cells: effect of particle size
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing, China
Nanotoxicology 4:319-30. 2010
..The findings may assist in the design of SNP applications and provide insights into their toxicity...
- The impact of size on tissue distribution and elimination by single intravenous injection of silica nanoparticles
Division of Toxicologic Pathology, National Institute of Toxicological Research, Korea Food and Drug Administration, 231 Jinhongno Enpyung ku, Seoul 122 704, Republic of Korea
Toxicol Lett 189:177-83. 2009
..Silica nanoparticles were trapped by macrophages in the spleen and liver and remained there until 4 weeks after the single injection...
- Coarse particles and mortality: evidence from a multi-city study in California
B J Malig
California Office of Environmental Health Hazard Assessment, Oakland, California 94612, USA
Occup Environ Med 66:832-9. 2009
- Interaction of gold nanoparticles with common human blood proteins
Silvia H De Paoli Lacerda
Center for Biological Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
ACS Nano 4:365-79. 2010
..K, as well as the degree of cooperativity of particle--protein binding (Hill constant, n), depends on particle size and the native protein structure...
- Preparation, characterization, and in vitro targeted delivery of folate-decorated paclitaxel-loaded bovine serum albumin nanoparticles
Key Laboratory of Forest Plant Ecology, Northeast Forestry University, Ministry of Education, Harbin, Heilongjiang, China
Int J Nanomedicine 5:669-77. 2010
..3% and 27.2%, respectively. The amount of folate conjugation was 9.22 μg/mg of bovine serum albumin. The folate-decorated nanoparticles targeted a human prostate cancer cell line effectively...
- Association of oxidative stress and PON1 with LDL and HDL particle size in middle-aged subjects
Institute for Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
Eur J Clin Invest 37:715-23. 2007
..This study investigates the connection between LDL and HDL particle heterogeneity and oxidative stress, antioxidative defence (AOD) and paraoxonase (PON1) status in a healthy middle-aged Serbian population...
- Self-nanoemulsifying drug delivery systems of tamoxifen citrate: design and optimization
Yosra S R Elnaggar
Department of Pharmaceutics, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt yosra
Int J Pharm 380:133-41. 2009
..Realizing drug incorporation into an optimized nano-sized SNEDD system that encompasses a bioactive surfactant, our results proposed that the prepared system could be promising to improve oral efficacy of the tamoxifen citrate...
- Cytotoxicity and immunological response of gold and silver nanoparticles of different sizes
Hung Jen Yen
Department of Chemical Engineering, National Chung Hsing University, 250 Kuo Kuang Road, Taichung 402, Taiwan, R O C
Small 5:1553-61. 2009
- Particle size of liposomes influences dermal delivery of substances into skin
D D Verma
Institut für Pharmazeutische Technologie und Biopharmazie, Philipps Universitat Marburg, Ketzerbach 63, 35037, Marburg, Germany
Int J Pharm 258:141-51. 2003
..The results indicated that the CF penetration was inversely related to the size of the liposomes, which was confirmed by the data of the confocal laser scanning microscopy studies...
- Nanosuspensions: a promising drug delivery strategy
V B Patravale
Pharmaceutical Division, University Institute of Chemical Technology, Matunga, Mumbai 400 019, India
J Pharm Pharmacol 56:827-40. 2004
..Rapid strides have been made in the delivery of nanosuspensions by parenteral, peroral, ocular and pulmonary routes. Currently, efforts are being directed to extending their applications in site-specific drug delivery...
- Pulmonary responses of mice, rats, and hamsters to subchronic inhalation of ultrafine titanium dioxide particles
CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
Toxicol Sci 77:347-57. 2004
..These differences can be explained both by pulmonary respy response and by particle dosimetry differences among these rodent species...
- Degradable polyethylenimine-alt-poly(ethylene glycol) copolymers as novel gene carriers
Mi Ran Park
School of Agricultural Biotechnology, Seoul National University, Seoul 151 742, Korea
J Control Release 105:367-80. 2005
- Development of superparamagnetic nanoparticles for MRI: effect of particle size, charge and surface nature on biodistribution
Laboratoire de Biophysique, Faculte de Medecine, Angers, France
J Microencapsul 13:245-55. 1996
..It was up to 3 X lower for electrically neutral particles than for charged particles. Coated particles presented higher vascular persistence. The diagnostic potential for liver, lymph node or vascular imaging were discussed...
- The effects of components of fine particulate air pollution on mortality in california: results from CALFINE
Office of Environmental Health Hazard Assessment, 16th Floor, 1515 Clay St, Oakland, CA 94612, USA
Environ Health Perspect 115:13-9. 2007
..5 pm in diameter (PM2.5). Little is known, however, about the relative effects of PM2.5 constituents. We examined associations between 19 PM2.5 components and daily mortality in six California counties...
- Nano/micro technologies for delivering macromolecular therapeutics using poly(D,L-lactide-co-glycolide) and its derivatives
Raghavendra C Mundargi
Industrial Biotechnology Group, Reliance Life Sciences Pvt Ltd, Dhirubhai Ambani Life Sciences Centre, Thane Belapur Road, Rabale, Navi Mumbai 400 701, India
J Control Release 125:193-209. 2008
..Drug encapsulation, particle size, additives added during formulation, molecular weight, ratio of lactide to glycolide moieties in PLGA and ..
- Role of target geometry in phagocytosis
Julie A Champion
Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA
Proc Natl Acad Sci U S A 103:4930-4. 2006
..Failure to create the required actin structure results in simple spreading and not internalization. Particle size primarily impacts the completion of phagocytosis in cases where particle volume exceeds the cell volume.
- Associations between air pollution and mortality in Phoenix, 1995-1997
T F Mar
Department of Environmental Health, University of Washington, Seattle, WA 98195 7234, USA
Environ Health Perspect 108:347-53. 2000
..5), PM(10), PM(CF) (p < 0.05), and elemental carbon. Factor analysis revealed that both combustion-related pollutants and secondary aerosols (sulfates) were associated with cardiovascular mortality...