particle size

Summary

Top Publications

  1. ncbi Toxic potential of materials at the nanolevel
    Andre Nel
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Science 311:622-7. 2006
  2. ncbi Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells
    B Devika Chithrani
    Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada
    Nano Lett 6:662-8. 2006
  3. ncbi Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology
    Marie Christine Daniel
    Molecular Nanosciences and Catalysis Group, LCOO, UMR CNRS No 5802, Universite Bordeaux I, 33405 Talence Cedex, France
    Chem Rev 104:293-346. 2004
  4. ncbi Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications
    Ajay Kumar Gupta
    Crusade Laboratories Limited, Southern General Hospital, 1345 Govan Road, Glasgow G51 4TF, Scotland, UK
    Biomaterials 26:3995-4021. 2005
  5. ncbi Elucidating the mechanism of cellular uptake and removal of protein-coated gold nanoparticles of different sizes and shapes
    B Devika Chithrani
    Institute of Biomaterials and Biomedical Engineering, Terrence Donnelly Center for Cellular and Biomolecular Research, University of Toronto, 160 College Street, 4th Floor, Toronto, Ontario M5S 3G9, Canada
    Nano Lett 7:1542-50. 2007
  6. ncbi Understanding biophysicochemical interactions at the nano-bio interface
    Andre E Nel
    Division of NanoMedicine, David Geffen School of Medicine and California NanoSystems Institute at UCLA, Los Angeles, California 90095, USA
    Nat Mater 8:543-57. 2009
  7. pmc Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles
    Gunter Oberdorster
    Department of Environmental Medicine, University of Rochester, Rochester, New York 14642, USA
    Environ Health Perspect 113:823-39. 2005
  8. ncbi Cardiovascular mortality and long-term exposure to particulate air pollution: epidemiological evidence of general pathophysiological pathways of disease
    C Arden Pope
    Brigham Young University, 130 FOB, Provo, UT 84602 2363, USA
    Circulation 109:71-7. 2004
  9. pmc Fine particulate air pollution and hospital admission for cardiovascular and respiratory diseases
    Francesca Dominici
    Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    JAMA 295:1127-34. 2006
  10. pmc Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis
    Joanna Rejman
    Department of Membrane Cell Biology, University of Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Biochem J 377:159-69. 2004

Detail Information

Publications303 found, 100 shown here

  1. ncbi Toxic potential of materials at the nanolevel
    Andre Nel
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Science 311:622-7. 2006
    ..The establishment of principles and test procedures to ensure safe manufacture and use of nanomaterials in the marketplace is urgently required and achievable...
  2. ncbi Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells
    B Devika Chithrani
    Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada
    Nano Lett 6:662-8. 2006
    ..g., tuning intracellular delivery rates and amounts by nanoscale dimensions and engineering complex, multifunctional nanostructures for imaging and therapeutics)...
  3. ncbi Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology
    Marie Christine Daniel
    Molecular Nanosciences and Catalysis Group, LCOO, UMR CNRS No 5802, Universite Bordeaux I, 33405 Talence Cedex, France
    Chem Rev 104:293-346. 2004
  4. ncbi Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications
    Ajay Kumar Gupta
    Crusade Laboratories Limited, Southern General Hospital, 1345 Govan Road, Glasgow G51 4TF, Scotland, UK
    Biomaterials 26:3995-4021. 2005
    ..that these nanoparticles have high magnetization values and size smaller than 100 nm with overall narrow particle size distribution, so that the particles have uniform physical and chemical properties...
  5. ncbi Elucidating the mechanism of cellular uptake and removal of protein-coated gold nanoparticles of different sizes and shapes
    B Devika Chithrani
    Institute of Biomaterials and Biomedical Engineering, Terrence Donnelly Center for Cellular and Biomolecular Research, University of Toronto, 160 College Street, 4th Floor, Toronto, Ontario M5S 3G9, Canada
    Nano Lett 7:1542-50. 2007
    ..These studies will provide guidelines for developing NPs for imaging and drug delivery applications, which will require "controlling" NP accumulation rate. These studies will also have implications in determining nanotoxicity...
  6. ncbi Understanding biophysicochemical interactions at the nano-bio interface
    Andre E Nel
    Division of NanoMedicine, David Geffen School of Medicine and California NanoSystems Institute at UCLA, Los Angeles, California 90095, USA
    Nat Mater 8:543-57. 2009
    ..This knowledge is important from the perspective of safe use of nanomaterials...
  7. pmc Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles
    Gunter Oberdorster
    Department of Environmental Medicine, University of Rochester, Rochester, New York 14642, USA
    Environ Health Perspect 113:823-39. 2005
    ..An interdisciplinary team approach (e.g., toxicology, materials science, medicine, molecular biology, and bioinformatics, to name a few) is mandatory for nanotoxicology research to arrive at an appropriate risk assessment...
  8. ncbi Cardiovascular mortality and long-term exposure to particulate air pollution: epidemiological evidence of general pathophysiological pathways of disease
    C Arden Pope
    Brigham Young University, 130 FOB, Provo, UT 84602 2363, USA
    Circulation 109:71-7. 2004
    ..Associations with specific cardiopulmonary diseases might be useful in exploring potential mechanistic pathways linking exposure and mortality...
  9. pmc Fine particulate air pollution and hospital admission for cardiovascular and respiratory diseases
    Francesca Dominici
    Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    JAMA 295:1127-34. 2006
    ..5 microm in aerodynamic diameter [PM2.5]) is limited. Results from the new national monitoring network for PM2.5 make possible systematic research on health risks at national and regional scales...
  10. pmc Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis
    Joanna Rejman
    Department of Membrane Cell Biology, University of Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Biochem J 377:159-69. 2004
    ..In the present study, we have investigated the effect of particle size on the pathway of entry and subsequent intracellular fate in non-phagocytic B16 cells, using a range of ..
  11. ncbi Silver nanoparticles as a new generation of antimicrobials
    Mahendra Rai
    Department of Biotechnology, SGB Amravati University, Amravati 444 602, Maharashtra, India
    Biotechnol Adv 27:76-83. 2009
    ..Hence, silver nanoparticles have emerged up with diverse medical applications ranging from silver based dressings, silver coated medicinal devices, such as nanogels, nanolotions, etc...
  12. pmc Renal clearance of quantum dots
    Hak Soo Choi
    Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Room SL B05, Boston, Massachusetts 02215, USA
    Nat Biotechnol 25:1165-70. 2007
    ..5 nm resulted in rapid and efficient urinary excretion and elimination of quantum dots from the body. This study provides a foundation for the design and development of biologically targeted nanoparticles for biomedical applications...
  13. ncbi Size-dependent cytotoxicity of gold nanoparticles
    Yu Pan
    Biomedical Engineering, Biointerface Laboratory, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany
    Small 3:1941-9. 2007
    ..The cellular response is size dependent, in that 1.4-nm particles cause predominantly rapid cell death by necrosis within 12 h while closely related particles 1.2 nm in diameter effect predominantly programmed cell death by apoptosis...
  14. doi Nanoparticle-mediated cellular response is size-dependent
    Wen Jiang
    Nat Nanotechnol 3:145-50. 2008
    ..The findings presented here may assist in the design of nanoscale delivery and therapeutic systems and provide insights into nanotoxicity...
  15. ncbi Effect of surface properties on nanoparticle-cell interactions
    Ayush Verma
    Department of Materials Science and Engineering, Massachusetts Institute of Technology MIT, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Small 6:12-21. 2010
    ..Challenges for undertaking a systematic study to elucidate nanoparticle-cell interactions are also discussed...
  16. ncbi Particle size-dependent organ distribution of gold nanoparticles after intravenous administration
    Wim H De Jong
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment RIVM, Antonie van Leeuwenhoeklaan 9, Bilthoven, The Netherlands
    Biomaterials 29:1912-9. 2008
    A kinetic study was performed to determine the influence of particle size on the in vivo tissue distribution of spherical-shaped gold nanoparticles in the rat...
  17. ncbi Translocation of inhaled ultrafine particles to the brain
    G Oberdorster
    Department of Environmental Medicine, University of Rochester, Rochester, New York 14642, USA
    Inhal Toxicol 16:437-45. 2004
    ..Depending on their particle size, inhaled UFP are efficiently deposited in nasal, tracheobronchial, and alveolar regions due to diffusion...
  18. pmc Understanding the nanoparticle-protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles
    Tommy Cedervall
    School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland
    Proc Natl Acad Sci U S A 104:2050-5. 2007
    ..The kinetic and equilibrium binding properties depend on protein identity as well as particle surface characteristics and size...
  19. ncbi Strategies in the design of nanoparticles for therapeutic applications
    Robby A Petros
    Department of Chemistry, University of North Texas, Denton, Texas 76203, USA
    Nat Rev Drug Discov 9:615-27. 2010
    ..This Review focuses on recent progress important for the rational design of such nanoparticles and discusses the challenges to realizing the potential of nanoparticles...
  20. ncbi Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration
    Jiangxue Wang
    Laboratory for Bio Environmental Effects of Nanomaterials and Nanosafety and Key Laboratory of Nuclear Analytical Techniques, National Center for NanoScience and Technology and Institute of High Energy Physics, Beijing 100080, PR China
    Toxicol Lett 168:176-85. 2007
    ..Biodistribution experiment showed that TiO(2) mainly retained in the liver, spleen, kidneys, and lung tissues, which indicated that TiO(2) particles could be transported to other tissues and organs after uptake by gastrointestinal tract...
  21. ncbi PVP-coated silver nanoparticles and silver ions induce reactive oxygen species, apoptosis and necrosis in THP-1 monocytes
    Rasmus Foldbjerg
    Department of Environmental and Occupational Medicine, Institute of Public Health, Aarhus University, Bartholins Alle 2, Bygn 1260, 8000 Aarhus, Denmark
    Toxicol Lett 190:156-62. 2009
    ..A drastic increase in ROS levels could be detected after 6-24h suggesting that oxidative stress is an important mediator of cytotoxicity caused by Ag NPs and Ag+...
  22. pmc Factors affecting the clearance and biodistribution of polymeric nanoparticles
    Frank Alexis
    Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Pharm 5:505-15. 2008
    ....
  23. pmc A toxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors
    Ron Hardman
    Nicholas School of the Environment and Earth Sciences, Duke University, Durham, North Carolina 27708, USA
    Environ Health Perspect 114:165-72. 2006
    ..Key words: environment, human health, nanomaterials, nanosized particles, nanotechnology, nanotoxicology, quantum dots, toxicology...
  24. ncbi Quantitative assessment of the comparative nanoparticle-uptake efficiency of a range of cell lines
    Tiago Dos Santos
    Centre for BioNano Interactions, School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland
    Small 7:3341-9. 2011
    ..Here, the effect of particle size on the in-vitro intracellular uptake of model fluorescent carboxyl-modified polystyrene nanoparticles is ..
  25. ncbi Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles
    Chunbai He
    State Key Laboratory of Genetic Engineering, Department of Pharmaceutical Sciences, School of Life Sciences, Fudan University, Shanghai 200433, China
    Biomaterials 31:3657-66. 2010
    To elucidate the effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles (NPs), rhodamine B (RhB) labeled carboxymethyl chitosan grafted NPs (RhB-CMCNP) and chitosan hydrochloride ..
  26. ncbi Curcumin and its nano-formulation: the kinetics of tissue distribution and blood-brain barrier penetration
    Yin Meng Tsai
    Institute of Traditional Medicine, National Yang Ming University, Taipei, Taiwan
    Int J Pharm 416:331-8. 2011
    ..The mean particle size and entrapment efficiency were 163nm and 46.9%, respectively...
  27. ncbi Solid lipid nanoparticles: production, characterization and applications
    W Mehnert
    Institute of Pharmacy, Department of Pharmaceutical Technology, Free University of Berlin, Kelchstr 31, D 12169, Berlin, Germany
    Adv Drug Deliv Rev 47:165-96. 2001
    ..The use of several analytical techniques is a necessity. Alternative structures and dynamic phenomena on the molecular level have to be considered. Aspects of SLN administration and the in vivo fate of the carrier are discussed...
  28. ncbi Unique cellular interaction of silver nanoparticles: size-dependent generation of reactive oxygen species
    C Carlson
    Applied Biotechnology Branch, Human Effectiveness Directorate, Wright Patterson Air Force Base, Dayton, Ohio 45433, USA
    J Phys Chem B 112:13608-19. 2008
    ..In summary, a size-dependent toxicity was produced by silver nanoparticles, and one predominant mechanism of toxicity was found to be largely mediated through oxidative stress...
  29. pmc Influenza virus aerosols in human exhaled breath: particle size, culturability, and effect of surgical masks
    Donald K Milton
    Maryland Institute for Applied Environmental Health, University of Maryland School of Public Health, College Park, Maryland, United States of America
    PLoS Pathog 9:e1003205. 2013
    ..Monitoring exhaled virus aerosols will be important for validation of experimental transmission studies in humans...
  30. pmc Asbestos, carbon nanotubes and the pleural mesothelium: a review of the hypothesis regarding the role of long fibre retention in the parietal pleura, inflammation and mesothelioma
    Ken Donaldson
    University of Edinburgh, Centre for Inflammation Research, Queens Medical Research Institute, 47 Little France Crescent, Edinburgh EH164TJ, UK
    Part Fibre Toxicol 7:5. 2010
    ....
  31. ncbi A review of the in vivo and in vitro toxicity of silver and gold particulates: particle attributes and biological mechanisms responsible for the observed toxicity
    Helinor J Johnston
    Centre for Nano Safety, School of Life Sciences, Edinburgh Napier University, Edinburgh, UK
    Crit Rev Toxicol 40:328-46. 2010
    ..Alternatively, a combination of both may be responsible, as the release of ions would be expected to be greater for smaller particles...
  32. ncbi Recent advances in iron oxide nanocrystal technology for medical imaging
    Claire Corot
    Guerbet Research, BP 57400, 95943 Roissy CDG, France
    Adv Drug Deliv Rev 58:1471-504. 2006
    ..Stem cell migration and immune cell trafficking, as well as targeted iron oxide nanoparticles for molecular imaging studies, are at the stage of proof of concept, mainly in animal models...
  33. ncbi Copper oxide nanoparticles are highly toxic: a comparison between metal oxide nanoparticles and carbon nanotubes
    Hanna L Karlsson
    Department of Biosciences and Nutrition at Novum, Karolinska Institutet, Stockholm, Sweden
    Chem Res Toxicol 21:1726-32. 2008
    ..The effects were not explained by soluble metal impurities. In conclusion, this study highlights the in vitro toxicity of CuO nanoparticles...
  34. pmc The effect of particle design on cellular internalization pathways
    Stephanie E A Gratton
    Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 105:11613-8. 2008
    The interaction of particles with cells is known to be strongly influenced by particle size, but little is known about the interdependent role that size, shape, and surface chemistry have on cellular internalization and intracellular ..
  35. ncbi Calculated absorption and scattering properties of gold nanoparticles of different size, shape, and composition: applications in biological imaging and biomedicine
    Prashant K Jain
    Laser Dynamics Laboratory, School of Chemistry and Biochemistry, Georgia, Institute of Technology, Atlanta, Georgia 30332 0400, USA
    J Phys Chem B 110:7238-48. 2006
    ....
  36. ncbi Stability and aggregation of metal oxide nanoparticles in natural aqueous matrices
    Arturo A Keller
    University of California, Santa Barbara, USA
    Environ Sci Technol 44:1962-7. 2010
    ..8 microm s(-1) V(-1) cm. These results are key for designing and interpreting nanoparticle ecotoxicity studies in various environmental conditions...
  37. ncbi In vitro models of the human epithelial airway barrier to study the toxic potential of particulate matter
    Barbara Rothen-Rutishauser
    University of Bern, Institute of Anatomy, Division of Histology, Baltzerstrasse 2, CH 3000 Bern 9, Switzerland
    Expert Opin Drug Metab Toxicol 4:1075-89. 2008
    ..Of particular interest are the ultrafine particles that are particularly toxic. In addition more and more nanoparticles are released into the environment; however, the potential health effects of these nanoparticles are yet unknown...
  38. ncbi The effect of particle size on the cytotoxicity, inflammation, developmental toxicity and genotoxicity of silver nanoparticles
    Margriet V D Z Park
    Department of Toxicogenomics, Maastricht University, 6200 MD Maastricht, The Netherlands
    Biomaterials 32:9810-7. 2011
    ..The most pronounced effect of silver nanoparticles and the role of particle size in determining these effects, also in comparison to silver ions, are largely unknown...
  39. pmc Role of target geometry in phagocytosis
    Julie A Champion
    Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA
    Proc Natl Acad Sci U S A 103:4930-4. 2006
    ..Failure to create the required actin structure results in simple spreading and not internalization. Particle size primarily impacts the completion of phagocytosis in cases where particle volume exceeds the cell volume.
  40. ncbi Development of glycyrrhetinic acid-modified stealth cationic liposomes for gene delivery
    Zhi Yao He
    West China School of Pharmacy, Sichuan University, Chengdu, Sichuan 610041, PR China
    Int J Pharm 397:147-54. 2010
    ..In conclusion, GA-PEG-CLs containing 5% GA-PEG-Chol might be one of the most potential gene vectors as hepatoma targeting therapy...
  41. pmc Cause-specific mortality and the extended effects of particulate pollution and temperature exposure
    Patrick G Goodman
    School of Physics, Dublin Institute of Technology, and St James Hospital, Dublin, Ireland
    Environ Health Perspect 112:179-85. 2004
    ..This analysis suggests that studies on the acute effects of air pollution have underestimated the total effects of temperature and particulate air pollution on mortality...
  42. pmc Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution
    C Arden Pope
    Department of Economics, Brigham Young University, 142 FOB, Provo, UT 84602, USA
    JAMA 287:1132-41. 2002
    ..However, studies of health effects of long-term particulate air pollution have been less conclusive...
  43. ncbi Nanomedicine: current status and future prospects
    S Moein Moghimi
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy, University of Brighton, Brighton, UK
    FASEB J 19:311-30. 2005
    ..Potential pitfalls or side effects associated with nanoparticles are also discussed...
  44. ncbi Cytotoxicity of nanoparticles independent from oxidative stress
    Eleonore Fröhlich
    Center for Medical Research, Medical University of Graz, A 8010 Graz, Austria
    J Toxicol Sci 34:363-75. 2009
    ..Protein containing solutions led to increases in particle size, decreased cytotoxicity and reduced cellular uptake...
  45. ncbi Preparation and evaluation of self-microemulsifying drug delivery system of oridonin
    Ping Zhang
    School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 210203, PR China
    Int J Pharm 355:269-76. 2008
    ..The absorption of oridonin from SMEDDS showed a 2.2-fold increase in relative bioavailability compared with that of the suspension. Our studies demonstrated the promising use of SMEDDS for the delivery of oridonin by the oral route...
  46. ncbi Cellular responses induced by silver nanoparticles: In vitro studies
    S Arora
    Centre for Nanobioscience, Agharkar Research Institute, G G Agarkar Road, Pune 411004, India
    Toxicol Lett 179:93-100. 2008
    ..5 microg/mL in both cell types). These results can be used to define a safe range of SNP for the intended application as a topical antimicrobial agent after appropriate in vivo studies...
  47. ncbi Chemistry and properties of nanocrystals of different shapes
    Clemens Burda
    Center for Chemical Dynamics and Nanomaterials Research, Department of Chemistry, Case Western Reserve University Millis 2258, Cleveland, Ohio 44106, USA
    Chem Rev 105:1025-102. 2005
  48. ncbi Acute toxicity and pharmacokinetics of 13 nm-sized PEG-coated gold nanoparticles
    Wan Seob Cho
    Division of Toxicologic Pathology, Department of Toxicological Research, National Institute of Toxicological Research, Korea Food and Drug Administration, 231 Jinhoungno Eunpyung ku, Seoul 122 704, Republic of Korea
    Toxicol Appl Pharmacol 236:16-24. 2009
    ..These findings of toxicity and kinetics of PEG-coated gold nanoparticles may have important clinical implications regarding the safety issue as PEG-coated gold nanoparticles are widely used in biomedical applications...
  49. ncbi Time evolution of the nanoparticle protein corona
    Eudald Casals
    Institut Catala de Nanotecnologia, Bellaterra, Barcelona, Spain
    ACS Nano 4:3623-32. 2010
    ..Mass spectrometry of the digested protein corona revealed albumin as the most abundant component which suggests an improved biocompatibility...
  50. ncbi Effects of cell culture media on the dynamic formation of protein-nanoparticle complexes and influence on the cellular response
    Gabriele Maiorano
    Italian Institute of Technology, Center for Bio Molecular Nanotechnology, Via Barsanti 73010 Arnesano, Lecce, Italy
    ACS Nano 4:7481-91. 2010
    ..These results show that, beyond an in-depth NPs characterization before cellular experiments, a detailed understanding of the effects elicited by cell culture media on NPs is crucial for standardized nanotoxicology tests...
  51. ncbi Uptake and intracellular fate of surface-modified gold nanoparticles
    Paola Nativo
    Department of Chemistry, University of Liverpool, Liverpool, United Kingdom
    ACS Nano 2:1639-44. 2008
    ..Successful nuclear targeting is demonstrated using surface modification with a cocktail of CPPs and a peptide acting as a nuclear localization signal (NLS)...
  52. pmc Clearance properties of nano-sized particles and molecules as imaging agents: considerations and caveats
    Michelle Longmire
    Molecular Imaging Program, NCI NIH Building 10, Bethesda, MD 20892 1088, USA
    Nanomedicine (Lond) 3:703-17. 2008
    ....
  53. ncbi Size-dependent cytotoxicity of amorphous silica nanoparticles in human hepatoma HepG2 cells
    Yang Li
    Department of Toxicology, School of Public Health, Jilin University, Changchun, Jilin 130021, PR China
    Toxicol In Vitro 25:1343-52. 2011
    ..results indicated that in HepG2 cells, the cytotoxicity generated by silica particles strongly depended on the particle size, and smaller silica particle possessed higher toxic effect...
  54. pmc The nanosilica hazard: another variable entity
    Dorota Napierska
    Unit of Lung Toxicology, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium
    Part Fibre Toxicol 7:39. 2010
    ....
  55. ncbi Medical application of functionalized magnetic nanoparticles
    Akira Ito
    Department of Biotechnology, School of Engineering, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8603, Japan
    J Biosci Bioeng 100:1-11. 2005
    ..Thus, the applications of these functionalized magnetic nanoparticles with their unique features will further improve medical techniques...
  56. ncbi Mediating tumor targeting efficiency of nanoparticles through design
    Steven D Perrault
    Institute of Biomaterials and Biomedical Engineering, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, ON, M5S 3E1, Canada
    Nano Lett 9:1909-15. 2009
    ..Our results provide design parameters for engineering nanoparticles for optimized tumor targeting of contrast agents and therapeutics...
  57. pmc Shape effects of filaments versus spherical particles in flow and drug delivery
    Yan Geng
    NanoBioPolymers and Molecular and Cell Biophysics Lab, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nat Nanotechnol 2:249-55. 2007
    ..Although these findings show that long-circulating vehicles need not be nanospheres, they also lend insight into possible shape effects of natural filamentous viruses...
  58. ncbi Impact of silver nanoparticles on human cells: effect of particle size
    Wei Liu
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing, China
    Nanotoxicology 4:319-30. 2010
    ..The findings may assist in the design of SNP applications and provide insights into their toxicity...
  59. ncbi Silver nanoparticles induce cytotoxicity by a Trojan-horse type mechanism
    Eun Jung Park
    College of Pharmacy, Dongduk Women s University, 23 1 Wolgok Dong, Seongbuk gu, Seoul 136 714, Republic of Korea
    Toxicol In Vitro 24:872-8. 2010
    ..It seemed that AgNPs were ionized in the cells to cause cytotoxicity by a Trojan-horse type mechanism suggested by previously reported studies...
  60. ncbi Galactosylated poly(ethylene glycol)-chitosan-graft-polyethylenimine as a gene carrier for hepatocyte-targeting
    Hu Lin Jiang
    Department of Agricultural Biotechnology, Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 151 921, South Korea
    J Control Release 131:150-7. 2008
    ..composition of Gal-PEG-CHI-g-PEI was characterized using (1)H nuclear magnetic resonance ((1)H NMR), and the particle size and zeta potential of Gal-PEG-CHI-g-PEI/DNA complexes were measured using dynamic light scattering (DLS)...
  61. pmc Respiratory health effects of airborne particulate matter: the role of particle size, composition, and oxidative potential-the RAPTES project
    Maciej Strak
    National Institute for Public Health and the Environment RIVM, Bilthoven, Netherlands
    Environ Health Perspect 120:1183-9. 2012
    ..High correlations among, and differential measurement errors of, individual components contribute to this uncertainty...
  62. ncbi Woodsmoke health effects: a review
    Luke P Naeher
    Department of Environmental Health Science, College of Public Health, University of Georgia, Athens, Georgia, USA
    Inhal Toxicol 19:67-106. 2007
    ..In addition, we provide recommendations for additional woodsmoke research...
  63. ncbi Health effects of fine particulate air pollution: lines that connect
    C Arden Pope
    Department of Economics, Brigham Young University, Provo, UT 84602 2363, USA
    J Air Waste Manag Assoc 56:709-42. 2006
    ....
  64. ncbi Silver colloid nanoparticles: synthesis, characterization, and their antibacterial activity
    Ales Panacek
    Department of Physical Chemistry, Palacky University, Svobody 26, 771 46 Olomouc, Czech Republic
    J Phys Chem B 110:16248-53. 2006
    ..Antibacterial activity of silver nanoparticles was found to be dependent on the size of silver particles. A very low concentration of silver (as low as 1.69 mug/mL Ag) gave antibacterial performance...
  65. ncbi Characterization of nanoparticle uptake by endothelial cells
    Jasmine Davda
    Department of Pharmaceutical Sciences, College of Pharmacy, 986025 Nebraska Medical Center, Omaha, NE 68198 6025, USA
    Int J Pharm 233:51-9. 2002
    ..Nanoparticles localized in the endothelium could provide prolonged drug effects because of their sustained release characterics, and also could protect the encapsulated agent from enzymatic degradation...
  66. pmc Surface-structure-regulated cell-membrane penetration by monolayer-protected nanoparticles
    Ayush Verma
    Department of Materials Science and Engineering, MIT, Massachusetts 02139, USA
    Nat Mater 7:588-95. 2008
    ..Our results offer a paradigm for analysing the fundamental problem of cell-membrane-penetrating bio- and macro-molecules...
  67. ncbi Polymer-based nanocapsules for drug delivery
    C E Mora-Huertas
    Universite de Lyon, F 69622, Lyon, France
    Int J Pharm 385:113-42. 2010
    ..Consequently, the information obtained allows establishing criteria for selecting a method for preparation of nanocapsules according to its advantages, limitations and behaviours as a drug carrier...
  68. ncbi A novel exposure system for the efficient and controlled deposition of aerosol particles onto cell cultures
    Melanie Savi
    Institute of Anatomy, University of Bern, Bern, Switzerland
    Environ Sci Technol 42:5667-74. 2008
    ..In situ analyses of the lung cells, e.g., the ciliary beat frequency, indicative of the defense capability of the cells, are complemented by off-line biochemical, physiological, and morphological cell analyses...
  69. pmc A high-performance nanobio photocatalyst for targeted brain cancer therapy
    Elena A Rozhkova
    The Center for Nanoscale Materials, Argonne National Laboratory, Argonne, Illinois 60439, USA
    Nano Lett 9:3337-42. 2009
    ..Synchrotron X-ray fluorescence microscopy (XFM) was applied for direct visualization of the nanobioconjugate distribution through a single brain cancer cell at the submicrometer scale...
  70. ncbi Endocytosis at the nanoscale
    Irene Canton
    The Krebs Institute, The Centre for Membrane Interaction and Dynamics, The Sheffield Cancer Research Centre, and the Department of Biomedical Science, The University of Sheffield, Western Bank, Sheffield, S10 2TN, UK
    Chem Soc Rev 41:2718-39. 2012
    ..Finally, we discuss different drug delivery strategies on how to evade lysosomal degradation to promote effective release of the cargo (376 references)...
  71. ncbi Residual polyvinyl alcohol associated with poly (D,L-lactide-co-glycolide) nanoparticles affects their physical properties and cellular uptake
    Sanjeeb K Sahoo
    Department of Pharmaceutical Sciences, University of Nebraska Medical Center 986025, Omaha, NE 68198 6025, USA
    J Control Release 82:105-14. 2002
    ..The residual PVA, in turn, influenced different pharmaceutical properties of nanoparticles such as particle size, zeta potential, polydispersity index, surface hydrophobicity, protein loading and also slightly influenced ..
  72. pmc The effect of sedimentation and diffusion on cellular uptake of gold nanoparticles
    Eun Chul Cho
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    Nat Nanotechnol 6:385-91. 2011
    ..Our results suggest that sedimentation needs to be considered when performing in vitro studies for large and/or heavy nanoparticles...
  73. ncbi Cellular uptake, cytotoxicity, and innate immune response of silica-titania hollow nanoparticles based on size and surface functionality
    Wan Kyu Oh
    School of Chemical and Biological Engineering, Seoul National University, 599 Gwanangro, Gwanak Gu, Seoul 151 742, Korea
    ACS Nano 4:5301-13. 2010
    ..These findings provide size- and surface functionality-dependent nanotoxicity and uptake of HNPs, and lead to HNPs for bioapplications such as drug delivery and imaging probe...
  74. ncbi Evaluating the uptake and intracellular fate of polystyrene nanoparticles by primary and hepatocyte cell lines in vitro
    Helinor J Johnston
    Biomedicine and Sport and Exercise Science Research Group, School of Life Sciences, Edinburgh Napier University, Edinburgh EH10 5DT, UK
    Toxicol Appl Pharmacol 242:66-78. 2010
    ..The findings were, in the main, comparable between primary rat hepatocytes and the different human hepatocyte cell lines...
  75. ncbi Characterization of nanomaterial dispersion in solution prior to in vitro exposure using dynamic light scattering technique
    Richard C Murdock
    Applied Biotechnology Branch, Human Effectiveness Directorate Air Force Research Laboratory HEPB, Wright Patterson Air Force Board, Ohio 45433, USA
    Toxicol Sci 101:239-53. 2008
    The need to characterize nanoparticles in solution before assessing the in vitro toxicity is a high priority. Particle size, size distribution, particle morphology, particle composition, surface area, surface chemistry, and particle ..
  76. ncbi Surface-modified superparamagnetic nanoparticles for drug delivery: preparation, characterization, and cytotoxicity studies
    Ajay Kumar Gupta
    Centre for Cell Engineering, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
    IEEE Trans Nanobioscience 3:66-73. 2004
    ....
  77. ncbi Silica and titanium dioxide nanoparticles cause pregnancy complications in mice
    Kohei Yamashita
    Department of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565 0871, Japan
    Nat Nanotechnol 6:321-8. 2011
    ..These detrimental effects are linked to structural and functional abnormalities in the placenta on the maternal side, and are abolished when the surfaces of the silica nanoparticles are modified with carboxyl and amine groups...
  78. pmc Time-series analysis of mortality effects of fine particulate matter components in Detroit and Seattle
    Jiang Zhou
    New York University School of Medicine, Tuxedo, New York 10987, USA
    Environ Health Perspect 119:461-6. 2011
    ..Recent toxicological and epidemiological studies have shown associations between particulate matter (PM) and adverse health effects, but which PM components are most influential is less well known...
  79. ncbi The kinetics of the tissue distribution of silver nanoparticles of different sizes
    D P K Lankveld
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment RIVM, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Biomaterials 31:8350-61. 2010
    ..Model parameter values were estimated by fitting to data. No clear relation between parameter values and corresponding particle diameters became apparent...
  80. ncbi Optimization and characterization of anionic lipoplexes for gene delivery
    Charudharshini Srinivasan
    Department of Pharmaceutical Sciences, University of Connecticut, 69 North Eagleville Road, Unit 3092, Storrs, CT 06269, USA
    J Control Release 136:62-70. 2009
    ..8 microg plasmid DNA. Biophysical studies (particle size analysis, gel electrophoresis, transmission electron microscopy (TEM), and confocal microscopy) were conducted ..
  81. ncbi Biodistribution of colloidal gold nanoparticles after intravenous administration: effect of particle size
    Ganeshchandra Sonavane
    Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, Japan
    Colloids Surf B Biointerfaces 66:274-80. 2008
    ..Another objective was to study effect of particle size on biological distribution of gold NP to enable their diverse applications in nanotechnology...
  82. ncbi Nanocarriers' entry into the cell: relevance to drug delivery
    Hervé Hillaireau
    School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA
    Cell Mol Life Sci 66:2873-96. 2009
    ..Nevertheless, various strategies are being actively investigated in order to tailor nanocarriers able to deliver anticancer agents, nucleic acids, proteins and peptides for therapeutic applications by these non-phagocytic routes...
  83. pmc Particle size, surface coating, and PEGylation influence the biodistribution of quantum dots in living mice
    Meike L Schipper
    Molecular Imaging Program at Stanford MIPS, Department of Radiology, Bio X Program, Stanford University, 318 Campus Drive, Palo Alto, CA 94305 5427, USA
    Small 5:126-34. 2009
    This study evaluates the influence of particle size, PEGylation, and surface coating on the quantitative biodistribution of near-infrared-emitting quantum dots (QDs) in mice...
  84. pmc Effects of prenatal exposure to surface-coated nanosized titanium dioxide (UV-Titan). A study in mice
    Karin S Hougaard
    National Research Centre for the Working Environment, Copenhagen Ø, Denmark
    Part Fibre Toxicol 7:16. 2010
    ..Consequently, also toxicological properties may change compared to the parent compound. We examined developmental and neurobehavioral effects following maternal exposure to a nanoparticulate UV-filter (UV-titan L181)...
  85. pmc Fine particulate matter constituents associated with cardiovascular hospitalizations and mortality in New York City
    Kazuhiko Ito
    New York University School of Medicine, Tuxedo, New York 10987, USA
    Environ Health Perspect 119:467-73. 2011
    ..We investigated this issue in New York City (NYC), where PM originates from regional and local combustion sources...
  86. pmc Spatial and temporal variation in PM(2.5) chemical composition in the United States for health effects studies
    Michelle L Bell
    School of Forestry and Environmental Studies, Yale University, New Haven, Connecticut, USA
    Environ Health Perspect 115:989-95. 2007
    ..Although numerous studies have demonstrated links between particulate matter (PM) and adverse health effects, the chemical components of the PM mixture that cause injury are unknown...
  87. ncbi In vitro toxicity of silica nanoparticles in human lung cancer cells
    Weisheng Lin
    Department of Chemistry and Environmental Research Center, University of Missouri Rolla, Rolla, MO 65409, USA
    Toxicol Appl Pharmacol 217:252-9. 2006
    ..In summary, exposure to SiO(2) nanoparticles results in a dose-dependent cytotoxicity in cultural human bronchoalveolar carcinoma-derived cells that is closely correlated to increased oxidative stress...
  88. ncbi Large porous particles for pulmonary drug delivery
    D A Edwards
    Department of Chemical Engineering, Pennsylvania State University, 204 Fenske Laboratory, University Park, PA 16802, USA
    Science 276:1868-71. 1997
    ..High systemic bioavailability of testosterone was also achieved by inhalation delivery of porous particles with a mean diameter (20 micrometers) approximately 10 times that of conventional inhaled therapeutic particles...
  89. ncbi Oxide nanoparticle uptake in human lung fibroblasts: effects of particle size, agglomeration, and diffusion at low concentrations
    Ludwig K Limbach
    Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zurich, Switzerland
    Environ Sci Technol 39:9370-6. 2005
    ..but physiologically relevant concentrations reveal a strong dependence of the amount of incorporated ceria on particle size, while nanoparticle number density or total particle surface area are of minor importance...
  90. pmc Mechanics of receptor-mediated endocytosis
    Huajian Gao
    Max Planck Institute for Metals Research, Heisenbergstrasse 3, D 70569 Stuttgart, Germany
    Proc Natl Acad Sci U S A 102:9469-74. 2005
    ..This model can also be extended to include the effect of clathrin coat. The results seem to show broad agreement with experimental observations...
  91. ncbi Paclitaxel-loaded PEGylated PLGA-based nanoparticles: in vitro and in vivo evaluation
    Fabienne Danhier
    Universite Catholique de Louvain, Unite de Pharmacie Galenique, Avenue Mounier, 73 20, 1200 Brussels, Belgium
    J Control Release 133:11-7. 2009
    ..Therefore, PTX-loaded nanoparticles may be considered as an effective anticancer drug delivery system for cancer chemotherapy...
  92. pmc The effect of fine and coarse particulate air pollution on mortality: a national analysis
    Antonella Zanobetti
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Environ Health Perspect 117:898-903. 2009
    ..5) and PM coarse on the increased risk of death for all causes, cardiovascular disease (CVD), myocardial infarction (MI), stroke, and respiratory mortality for the years 1999-2005...
  93. pmc Protein adsorption and cellular uptake of cerium oxide nanoparticles as a function of zeta potential
    Swanand Patil
    Advanced Materials Processing and Analysis Center, Department of Mechanical, Materials and Aerospace Engineering, University of Central Florida, Orlando, FL 32816, USA
    Biomaterials 28:4600-7. 2007
    ..These results demonstrate that electrostatic interactions can play an important factor in protein adsorption and cellular uptake of nanoparticles...
  94. pmc Influence of apolipoprotein (Apo) A-I structure on nascent high density lipoprotein (HDL) particle size distribution
    Charulatha Vedhachalam
    Lipid Research Group, Gastroenterology, Hepatology, and Nutrition Division, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4318, USA
    J Biol Chem 285:31965-73. 2010
    ..The stability of the apoA-I N-terminal helix bundle domain and the hydrophobicity of the C-terminal domain are important determinants of both nascent HDL particle size and their rate of formation.
  95. ncbi Ceramic-based nanoparticles entrapping water-insoluble photosensitizing anticancer drugs: a novel drug-carrier system for photodynamic therapy
    Indrajit Roy
    Institute of Lasers, Photonics and Biophotonics, Department of Chemistry, State University of New York, Buffalo, NY 14260 3000, USA
    J Am Chem Soc 125:7860-5. 2003
    ..Significant damage to such impregnated tumor cells was observed upon irradiation with light of wavelength 650 nm. Thus, the potential of using ceramic-based nanoparticles as drug carriers for photodynamic therapy has been demonstrated...
  96. ncbi Size-dependency of nanoparticle-mediated gene transfection: studies with fractionated nanoparticles
    Swayam Prabha
    Department of Pharmaceutical Sciences, 986025 University of Nebraska Medical Center, Omaha, NE 68198 6025, USA
    Int J Pharm 244:105-15. 2002
    ..The results suggest that the particle size is an important factor, and that the smaller-sized fraction of the nanoparticle formulation predominantly ..
  97. ncbi Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size
    H Cabral
    Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Hongo, Bunkyo ku, Japan
    Nat Nanotechnol 6:815-23. 2011
    ..We also showed that the penetration and efficacy of the larger micelles could be enhanced by using a transforming growth factor-β inhibitor to increase the permeability of the tumours...
  98. pmc Ambient air pollution and low birth weight in Connecticut and Massachusetts
    Michelle L Bell
    School of Forestry and Environmental Studies, Yale University, New Haven, Connecticut 06511, USA
    Environ Health Perspect 115:1118-24. 2007
    ..Several studies have examined whether air pollution affects birth weight; however results vary and many studies were focused on Southern California or were conducted outside of the United States...
  99. ncbi Circulating microparticles: pathophysiology and clinical implications
    Andrea Piccin
    Irish Blood Transfusion Service, James s Street, Dublin 8, Ireland
    Blood Rev 21:157-71. 2007
    ..In addition the complex role of microparticles in vascular and cardiovascular diseases is an area of immense interest, that promises to yield important advances into diagnosis and therapy...
  100. pmc Chronic fine and coarse particulate exposure, mortality, and coronary heart disease in the Nurses' Health Study
    ROBIN C PUETT
    South Carolina Cancer Prevention and Control Program and Department of Epidemiology, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina 29201, USA
    Environ Health Perspect 117:1697-701. 2009
    ..5 and 10 microm (PM(10-2.5)), may also be important. With respect to mortality and cardiovascular events, questions remain regarding the relative strength of effect sizes for chronic exposure to fine and coarse particles...
  101. pmc The impact of polycyclic aromatic hydrocarbons and fine particles on pregnancy outcome
    J Dejmek
    Laboratory of Genetic Ecotoxicology, Regional Institute of Hygiene of Central Bohemia and Institute of Experimental Medicine, Academy of Science of the Czech Republic, Prague, Czech Republic
    Environ Health Perspect 108:1159-64. 2000
    ..The results prove that exposure to c-PAHs in early gestation may influence fetal growth. The particulate matter-IUGR association observed earlier may be at least partly explained by the presence of c-PAHs on particle surfaces...

Research Grants77

  1. Genetic contributors to diabetes and dyslipidemia in African Americans
    Michele M Sale; Fiscal Year: 2010
    ..genetic contributors to lipoprotein subclasses in African Americans using the lipoprotein subclass profile (particle size and concentration for multiple subclasses of VLDL, LDL, and HDL) assessed by NMR at LipoScience, Inc...
  2. Inhaled Aminoglycoside Formulafor Plague and Tularemia
    James Talton; Fiscal Year: 2005
    ..objectives of this Project is to (1) compare steptomycin and gentamicin particle formulations measuring the particle size, aerosol properties, and cytotoxicity in pulmonary cell cultures in vitro and (2) compare inhaled ..
  3. Asthma Treatment with a Novel Drug Aerosol Generator
    William Shen; Fiscal Year: 2004
    ..treatment because of (1) the difficulty in coordinating actuation and inspiration, (2) excessively large particle size of generated aerosols inadequate for delivery to therapeutically important small bronchioles, and (3) ..
  4. Near-Infrared VCD of Chiral Pharmaceuticals
    Laurence Nafie; Fiscal Year: 2004
    ..The sensitivity of FT-near-IR VCD to particle size, moisture Content and aggregation in protein pharmaceuticals will be determined...
  5. INHALED PARTICLE CHARACTERISTICS AND EARLY LUNG EFFECTS
    William Beckett; Fiscal Year: 2002
    ..cadmium) causing COPD in the workplace have been characterized based on chemical composition and respirable particle size. These findings suggest that the much broader range of workplace dusts may in certain conditions contribute to ..
  6. Pharmacogenetics of obesity and endocannabinergic modulation (POEM)
    Russell A Wilke; Fiscal Year: 2012
    ..to be associated with lipid levels in the original cohort will also be tested for association with lipoprotein particle size distribution in these 504 subjects...
  7. Nanopolymersomes for Transcutaneous Co-Delivery of Vaccine Antigens and Adjuvants
    PAUL CAMILLE TUMEH; Fiscal Year: 2013
    ..I will test NPSs varying in copolymer composition, particle size, deformability, and mechanical toughness to optimize this delivery system...
  8. Gold Nanoparticle Assisted Delivery of Cancer Vaccines and Immune Stimulants
    Adam Lin; Fiscal Year: 2013
    ..From preliminary characterizations of AuNVs, conjugation yield is very high (~90%) and the overall particle size remained sub-100nm. This will allow potential lymphatic drainage post subcutaneous injection...
  9. Fully Biodegradable Polymersome-encapsulated Hemoglobin as a Novel Nanoparticle-b
    PAIMAN PETER GHOROGHCHIAN; Fiscal Year: 2010
    ..These dispersions will be rigorously characterized for particle size and morphology, hemoglobin encapsulation efficiency and methamoglobin (metHb) level, We will also characterize ..
  10. Predictive Toxicological Paradigms to Establish Inhalation Toxicology Models
    ANDRE ELIAS NEL; Fiscal Year: 2010
    ..We will also assess ROS production. The NM properties that will be assessed include particle size, size distribution, dispersibility, zeta-potential, TEM, XRD and BET analysis...
  11. New Personal Sampling Methods that Conform to an Aerosol Deposition Convention
    DARRAH KAYE SLEETH; Fiscal Year: 2013
    ..Most particle size-selective aerosol samplers that are currently used to measure personal exposures in the workplace (i.e...
  12. Monolithic Media and Technology for Bioprocessing
    ALEX G BONNER; Fiscal Year: 2011
    ..sorbents for these applications are in the form of beads which characteristically have large pores and a large particle size. The large pores are needed to accommodate the proteins;the particle size needs to be large to minimize the ..
  13. Healthy Worker Effect, Occupational Exposure to PM and Cardiopulmonary Mortality
    ELLEN AURA EISEN; Fiscal Year: 2013
    ..samples, we will compare the physicochemical composition of MWF with air pollution and cigarette smoke - by particle size fractions of PM3.5 and PM3.5-9.8 - using common analytic techniques...
  14. Role of Genes in Exceptional Longevity in Humans
    NIR J BARZILAI; Fiscal Year: 2012
    ..These lipoprotein particle size are lower in offspring that have age-related diseases...
  15. Impact of corn grind diameter and housing environment on performance and presence
    Kenneth Anderson; Fiscal Year: 2013
    ..corn in the finely ground mash diet will be ground in a hammermill equipped with a 3-mm screen with an average particle size of 560 yen[unreadable]...
  16. PHYSIOLOGY OF FLUOROCARBON OXYGEN TRANSPORT
    LELAND CLARK; Fiscal Year: 1992
    ..which it is dispersed in the blood, cardiac output, arterial oxygen and carbon dioxide tensions, fluorocarbon particle size, type of emulsifier used, acid-base balance, and other factors...
  17. Pulmonary Formulation of tPA for Plastic Bronchitis
    Kathleen A Stringer; Fiscal Year: 2010
    ..of pf-tPA to reduce fibrin cast mass;2) To demonstrate pediatric pulmonary delivery by acquiring aerodynamic particle size data to estimate lung distribution and respirable dose of nebulized pf-tPA...
  18. Development of Age-Appropriate Fast Disintegrating Pediatric Granules and Tablets
    MOJI ADEYEYE; Fiscal Year: 2009
    ..of the drug include powder X- Ray diffraction, differential scanning calorimetry, thermogravimetry and particle size analysis. These properties could affect the solubility, disintegration and dissolution of the final product...
  19. Intra-pulmonary aerosol delivery for intubated pediatric patients
    AMIR A NAQWI; Fiscal Year: 2013
    ..Aerosol generation and particle size distribution will be characterized with in-vitro models...
  20. AEROSOL FUROSEMIDE FOR DYSPNEA RELIEF: LABORATORY AND CLINICAL STUDIES
    Robert B Banzett; Fiscal Year: 2013
    ..aim is to show that this can be achieved by: a) controlling aerosol inhalation characteristics such as aerosol particle size, inspiratory volume and flow rate, and residence time (i.e...
  21. Alternate day fasting for weight loss, weight maintenance, and cardio-protection
    KRISTA AMY VARADY; Fiscal Year: 2013
    ..in traditional CHD risk parameters (blood pressure, plasma lipid levels, cholesterol synthesis rate, LDL particle size, and CRP) and emerging CHD risk parameters (fat cell- derived hormones, body fat distribution, and fat cell ..
  22. HTLV-1 Particle Analysis and Gag Interactions
    Louis M Mansky; Fiscal Year: 2013
    ..In this application, we propose to investigate questions related to HTLV-1 particle size, Gag stoichiometry in particles, and HTLV-1 Gag interactions in living cells using multiple experimental ..
  23. Continuous Countercurrent Tangential Chromatography
    Oleg Shinkazh; Fiscal Year: 2011
    ..The optimal membrane pore size, resin particle size, and operating conditions for CCTC (e.g...
  24. Fate and Effects of Nanoparticles: Relationship to Physicochemical Properties
    ALISON CORY PEARSON ELDER; Fiscal Year: 2010
    ..is that the surface area and, therefore the number of reactive molecules at the particle surface, increases as particle size decreases...
  25. TLR Ligand and Pesticide Exposure in Farms: Role in Atopic Immune Responses
    Atin Adhikari; Fiscal Year: 2011
    ..an inhalable sampler and a NIOSH-developed size- selective sampling system with two-stage cyclone (three particle size fractions: <1.0 5m, 1 - 1.8 5m, and >1...
  26. Coordination of signaling during phagocytosis
    Joel A Swanson; Fiscal Year: 2010
    ..Inhibitors of PI3K affect phagocytosis of large particles more than that of small particles, which indicates particle size-dependent contributions of 3'Pls to phagocytosis...
  27. Mosquito Vector Control Using Bt Coupled to Seed Oil Bodies
    Mohd Amir Abdullah; Fiscal Year: 2009
    ..Seeds will be milled into Bt-flour, with a particle size approximating that of food consumed by filter-feeding larvae...
  28. In vitro fluid capacity-limited dissolution testing and its kinetic relation to i
    Masahiro Sakagami; Fiscal Year: 2013
    ..Drug (OGD) initiated a study to evaluate the sensitivity of pharmacokinetics to differences in the aerodynamic particle size distribution (APSD) for three different, investigational dry powder inhaler (DPI) formulations of a poorly ..
  29. Characterization of Floor Level Aerosol (PM) Exposure and Childhood Asthma
    Stuart Shalat; Fiscal Year: 2009
    ..household: 1) mass concentration of PM10 particles measured by a real- time monitoring device;2) real-time particle size and number distribution (0...
  30. Osteogenic Calcium Phosphate Nanoparticles with Designable Drug Release Kinetics
    Vuk Uskoković; Fiscal Year: 2012
    ..The central hypothesis of the proposed study is that stoichiometry and the particle size of calcium phosphates can be used to tune the kinetics of the release of the encapsulated drug. Dr...
  31. Sources and Wetting Characteristics of Respirable Coal and Silica Dust from Selec
    YOGINDER P CHUGH; Fiscal Year: 2012
    ..The overall goals of this research are to: 1) Develop physical and chemical characteristics of different particle size coal and quartz/ silica dusts from different unit operations, 2) Utilize MSHA and company dust sampling data ..
  32. Proteostasis Network Factors Involved in Apolipoprotein B Folding and Secretion
    Joseph Genereux; Fiscal Year: 2012
    ..One will involve fusing fluorescent proteins to apoB, and using time-resolved FRET to determine particle size polydispersity...
  33. Novel Nanorods for High Efficiency Medical Imaging Applications
    Christopher J Summers; Fiscal Year: 2011
    ..Although phosphor screens made from micron-sized phosphors are efficient, bright X-ray converters, their large particle size produces a great deal of scatter, which limits their spatial resolution...
  34. Mechanistic analysis of transport through the mucus barrier
    Katharina Ribbeck; Fiscal Year: 2013
    ..While the relevance of particle size, net charge, and hydrophobicity for mucus transport has been studied in isolation, the effect of combining ..
  35. Ultrahigh Resolution Optical Barcode
    ROBERT C HAUSHALTER; Fiscal Year: 2011
    ..the use of variable emitter concentrations, high quantum efficiency, excellent photostability, variable particle size, and a low cost, automated parallel synthesis...
  36. Real-time detection and identification of single viruses
    Lukas Novotny; Fiscal Year: 2011
    ..removes noise due to phase variations, multicolor operation allows us to eliminate the dependence on particle size and to obtain a chemically-specific fingerprint for the viruses to be recognized...
  37. Precision Particle Fabrication-enabled Betamethasone-loaded Microspheres for Tran
    Milind Singh; Fiscal Year: 2012
    ..The central advantage of our approach is that PPF technology allows for precise control of particle size, shape, material, and release rates...
  38. Toxicity and Efficacy of Gold Nanoparticle Photothermal Therapy in Cancer
    Dong M Shin; Fiscal Year: 2013
    ..To this end the effects of particle size, surface coating and tumor targeting ligands on the biodistribution and toxicity of Au NR model systems will ..
  39. Nanoparticle Effects on Epithelial Cell Protein Expression and Function
    Frank A Witzmann; Fiscal Year: 2012
    ..An important aspect of this project is to accurately assess the elemental composition, particle number, particle size distribution, particle shape, and surface area of the primary particle and agglomerated material, as well as ..
  40. An in vitro-in vivo correlation model to predict serum non-transferrin bound iron
    Amy Barton Pai; Fiscal Year: 2013
    ..Formulation study -Each formulation to be studied will be fully characterized in terms of molecular weight, particle size distribution and physicochemical characteristics. Specific Aim 2...
  41. Pregravid biomarkers of GDM risk, fetal growth and progression to diabetes
    MONIQUE MARIE HEDDERSON; Fiscal Year: 2013
    ..to evaluate whether biomarkers of: 1) insulin resistance (adiponectin, HMW adiponectin, Fetuin-A and LDL-C particle size), 2) inflammation (CRP), and 3) oxidative stress (GGT) assessed before pregnancy, are associated with ..
  42. Characterization of Erbb Receptors in Nanoparticles
    PAUL THOMAS HENDERSON; Fiscal Year: 2013
    ..The NLPs present a distinct advantage over currently used model membranes in terms of particle size monodispersity and solubility...
  43. Characterization of manganese exposure biomarkers among welder apprentices
    Noah S Seixas; Fiscal Year: 2012
    ..In addition, the particle size distribution of Mn and total welding fume particulate will be evaluated to determine its influence on exposure ..
  44. Tunable affinity and heat stable antibody targeting of nanoparticles
    Todd Sulchek; Fiscal Year: 2012
    ..particle adhesion and agglutination as a function of a) VLR molecular valency, b) VLR linker spacing, c) particle size, and d) temperature...
  45. LSU Superfund Research Center - Environmentally Persistent Free Radicals
    Barry Dellinger; Fiscal Year: 2013
    ..stress, and a Computational Core to calculate the properties of EPFR-particle systems as a function of particle size. The program also includes, an Administrative Core, Research Translation Core, Community Outreach Core, and ..
  46. Engineering an in vitro lung model for air pollutant deposition and toxicology
    John Volckens; Fiscal Year: 2010
    ..The investigator's model will accomplish this task by approximating particle size-specific deposition patterns of particulate aerosols to pulmonary epithelial cells housed within a state-of-..
  47. Engineered Organic Particles of Controlled Size, Shape and Surface Chemistry for
    Joseph M DeSimone; Fiscal Year: 2012
    ..monitored by luciferase gene silencing will be evaluated as a function of particle matrix composition, particle size and shape and pathway of internalization...
  48. Nanoparticle Generator for Animal Inhalation Experiments
    Amir Naqwi; Fiscal Year: 2009
    ..Their respirable particle size range is less than 500 nm with deposition efficiency increasing consistently down to a few tens of nm...
  49. A Silicate Prodrug Strategy for Enhancing Nanoparticle Delivery of Taxanes
    CHRIS MACOSKO; Fiscal Year: 2011
    ..Prodrug-Loaded BCP Nanoparticles (Materials Science) drug load levels;nanoparticle biodistribution;particle size and stability optimization III...
  50. Role of Physical Properties in Pharmacokinetics, Biodistribution and Tumor Uptake
    ISAAC MORRIS ADJEI; Fiscal Year: 2012
    ..In this study, the role that particle size, charge and the presence of targeting ligands on NP play in their biodistribution, pharmacokinetic and tumor ..
  51. Apoptosis Inducing to Enhance Tumor Targeting
    Ze Lu; Fiscal Year: 2012
    ..In addition, the particle size and surface properties were selected to enhance the particle retention in the peritoneal cavity and the ..
  52. A Portable Spectrometer for Inhalable Aerosol Size Distributions
    John Volckens; Fiscal Year: 2013
    ..and low-velocity wind tunnel experiments;(3) Test sampler performance in the field by characterizing inhalable particle size distributions for organic dust hazards in dairy and grain handling facilities...
  53. Camptothecin-Containing Nanoparticles: Control Over Particle Size, Biodistributio
    Jianjun Cheng; Fiscal Year: 2012
    ..However, the correlation of particle size and surface property with its in vivo biodistribution and cancer targeting still remains elusive...
  54. Role of carrier plasma protein corona in their vascular wall localization
    LOLA ENIOLA-ADEFESO; Fiscal Year: 2013
    ..human blood flow;(2) the coupled effect of material type and material hydrophobicity, surface coating, and particle size and shape in prescribing carrier margination;and (3) the role of cell-carrier interaction and electrostatic ..
  55. Standardization of Methods to Measure Waterpipie Smoke Emissions and Exposure
    Pamela I Clark; Fiscal Year: 2012
    ..Variation in particle size distribution with changes in WP configuration will also be assessed...
  56. Mainstream Smoke Composition and Toxin Exposure from Prototypical Cigar Products
    WALLACE BRUCE PICKWORTH; Fiscal Year: 2013
    ..The mainstream smoke generated by machine smoking will be characterized by particle size (fine and ultrafine), distribution and gas-phase toxic/carcinogenic components...
  57. Enhancement of Antileukemic Activity by Gold Nanoparticles
    NICHOLAS ALEXANDER KOTOV; Fiscal Year: 2010
    ..The fundamental and novel aspects of the project include (1) the verification of particle size in nanoscale being one of the primary factors determining the particle retention by reticular endothelial ..
  58. High Strength Bioresorbable PLA/CaP Composites
    Tongxin Wang; Fiscal Year: 2013
    ..Moreover, by additional optimizing a number of critical variables (e.g. CaP phase, particle size, PLA molecular weight (MW) and CaP/PLA mass ratio), we seek to adjust the mechanical strength of PLA/CaP ..
  59. High volume high throughput affordable parallel acoustic flow cytometry
    Steven W Graves; Fiscal Year: 2013
    ..applications, we must dramatically increase the analytical rate, volumetric sample delivery, and the useable particle size of flow cytometers...
  60. Evaluation of Dissolution Methods for Complex Parenteral Liposomal Formulations
    Paul M Bummer; Fiscal Year: 2013
    ..g., ammonium sulfate concentration, pegylation, particle size, etc...
  61. Engineering Microparticles for Taste-Masking and Controlled Release of Pediatric
    Milind Singh; Fiscal Year: 2012
    ..The central advantage of PPF technology lies in its precise control of particle size, shape, material, and release rates...
  62. Comprehensive evaluation of formulation effects on metered dose inhaler performan
    JAY HOLT; Fiscal Year: 2013
    ..will highlight factors contributing to accuracy and reproducibility of the delivered dose and aerodynamic particle size distribution. These outcomes are relevant to efficacy, and important for development of predictive models...
  63. Bioavailibility and toxicity of engineered nanomaterials
    LYNELL SKEWIS; Fiscal Year: 2010
    ..The specific aims of this study are: 1) determine the influence of particle size, shape, and surface change on the transepithelial transport eficiency, 2) determine the intracellular fate of ..
  64. Mucus Penetrating Nanoparticles for Vaginal Drug Delivery
    Justin Hanes; Fiscal Year: 2009
    ..In Aim 1, we will fully characterize particle size and surface properties, and use particle tracking to observe diffusional transport rates of mucus-penetrating ..
  65. Minstrel HTUV Gallery 700 Automated Crystal Growth and Imaging System
    Jennifer A Doudna; Fiscal Year: 2013
    ..can afford some of the highest-resolution views of a particular system, and is not limited by the particle size, the use of this method is widespread, and has contributed the greatest numbers of structures to the field [1]...
  66. PHYSIOCHEMICAL EFFECTS OF DIETARY FIBER IN HUMANS
    JUDITH MARLETT; Fiscal Year: 1991
    ..each fiber will be determined by measuring bile acid binding, cation exchange and water holding capacities and particle size in vitro...
  67. RADIOPAQUE FLUOROCARBON IN DIAGNOSTIC RADIOLOGY
    David Long; Fiscal Year: 1980
    ..Preliminary studies show that small particle size emulsions radiopacify the entire cardiovascular system for several hours after injection...
  68. DEPOSITION OF VOLATILE AEROSOLS IN THE RESPIRATORY TRACT
    Sidney Soderholm; Fiscal Year: 1991
    ..physical properties of the airborne system, including exposure concentration, saturation vapor concentration, particle size, and blood/gas partition coefficient...
  69. NEW METHODS FOR EVAL OF ORGANIC DUST AEROSOLS
    Stephen Reynolds; Fiscal Year: 2006
    ..and HAM, will be compared to the gravimetric methods, and their performance characterized in response to particle size distributions determined using a Grimm...
  70. FAILURE MECHANISMS OF REVISION JOINT REPLACEMENT
    Joan Bechtold; Fiscal Year: 2000
    ..The study will proceed as follows: in Year 1, the study of the particle size on membrane and bone characteristics will be completed...
  71. RESPIRATOR EFFICACY VERSUS TUBERCULOSIS AEROSOLS
    John Koerner; Fiscal Year: 2000
    ..that result from the aerosolization of solutions containing Mycobacterium tuberculosis; 2) to determine the particle size distribution and particle shapes characteristic of the aerosol generated by the cough of humans infectious ..
  72. Extra-Fine Inhaled Corticosteroid Effect on Distal Lung Disease in Asthma
    Michelle Zeidler; Fiscal Year: 2007
    ..the mainstay of asthma treatment, cannot effectively reach the distal lung due to their relatively large particle size. The recent transition to non-CFC inhalers has created a new class of extra-fine ICS aerosols which, ..
  73. Nanocrystalline Phosphors for Medical Imaging Applications
    CHRISTOPHER SUMMERS; Fiscal Year: 2009
    ..Although phosphor screens made from micron-sized phosphors are efficient, bright X-ray converters, their large particle size produces a great deal of scatter, which limits their spatial resolution...
  74. Cardiovascular Consequences of Thyroid Dysfunction
    Elizabeth Pearce; Fiscal Year: 2007
    ..overall hypothesis of this proposal is that abnormal thyroid function is associated with alterations in lipid particle size, in endothelial reactivity, and in cardiac contractility, which result in increased risk for adverse clinical ..
  75. COAL DUST PARTICLE SIZE AND RESPIRATORY DISEASE
    Thomas Robins; Fiscal Year: 1991
    The proposed research will explore the importance of particle size fractions and temporal aspects of exposure to coal mine dust to the development of chronic bronchitis and airways obstruction in underground coal miners...
  76. ACTION OF ALCOHOL & QUERCETIN ON ANTI-ATHEROGENIC FACTORS & ATHEROGENESIS
    Raj Lakshman; Fiscal Year: 2007
    ..of quercetin and/or ethanol on AAA factors (PON status, HDL's capacity to inhibit LDL oxidation, LDL particle size, and OxLDL level in aorta) with the extent of atherosclerosis in the aorta (morphometric analysis of aorta) in ..
  77. Nanoengineered HIV-1 Vaccines Based on Tat
    RUSSELL MUMPER; Fiscal Year: 2004
    ..be coated on both types of nanoparticles, and iii) characterize the nanoparticle-based vaccines in terms of particle size, surface charge, stability, and cell uptake and/or transfection in human dendritic cells...