- Toxic potential of materials at the nanolevel
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
Science 311:622-7. 2006
..The establishment of principles and test procedures to ensure safe manufacture and use of nanomaterials in the marketplace is urgently required and achievable...
- Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells
B Devika Chithrani
Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada
Nano Lett 6:662-8. 2006
..g., tuning intracellular delivery rates and amounts by nanoscale dimensions and engineering complex, multifunctional nanostructures for imaging and therapeutics)...
- Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology
Marie Christine Daniel
Molecular Nanosciences and Catalysis Group, LCOO, UMR CNRS No 5802, Universite Bordeaux I, 33405 Talence Cedex, France
Chem Rev 104:293-346. 2004
- Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications
Ajay Kumar Gupta
Crusade Laboratories Limited, Southern General Hospital, 1345 Govan Road, Glasgow G51 4TF, Scotland, UK
Biomaterials 26:3995-4021. 2005
..that these nanoparticles have high magnetization values and size smaller than 100 nm with overall narrow particle size distribution, so that the particles have uniform physical and chemical properties...
- Elucidating the mechanism of cellular uptake and removal of protein-coated gold nanoparticles of different sizes and shapes
B Devika Chithrani
Institute of Biomaterials and Biomedical Engineering, Terrence Donnelly Center for Cellular and Biomolecular Research, University of Toronto, 160 College Street, 4th Floor, Toronto, Ontario M5S 3G9, Canada
Nano Lett 7:1542-50. 2007
..These studies will provide guidelines for developing NPs for imaging and drug delivery applications, which will require "controlling" NP accumulation rate. These studies will also have implications in determining nanotoxicity...
- Understanding biophysicochemical interactions at the nano-bio interface
Andre E Nel
Division of NanoMedicine, David Geffen School of Medicine and California NanoSystems Institute at UCLA, Los Angeles, California 90095, USA
Nat Mater 8:543-57. 2009
..This knowledge is important from the perspective of safe use of nanomaterials...
- Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles
Department of Environmental Medicine, University of Rochester, Rochester, New York 14642, USA
Environ Health Perspect 113:823-39. 2005
..An interdisciplinary team approach (e.g., toxicology, materials science, medicine, molecular biology, and bioinformatics, to name a few) is mandatory for nanotoxicology research to arrive at an appropriate risk assessment...
- Cardiovascular mortality and long-term exposure to particulate air pollution: epidemiological evidence of general pathophysiological pathways of disease
C Arden Pope
Brigham Young University, 130 FOB, Provo, UT 84602 2363, USA
Circulation 109:71-7. 2004
..Associations with specific cardiopulmonary diseases might be useful in exploring potential mechanistic pathways linking exposure and mortality...
- Fine particulate air pollution and hospital admission for cardiovascular and respiratory diseases
Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
JAMA 295:1127-34. 2006
..5 microm in aerodynamic diameter [PM2.5]) is limited. Results from the new national monitoring network for PM2.5 make possible systematic research on health risks at national and regional scales...
- Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis
Department of Membrane Cell Biology, University of Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
Biochem J 377:159-69. 2004
..In the present study, we have investigated the effect of particle size on the pathway of entry and subsequent intracellular fate in non-phagocytic B16 cells, using a range of ..
- Silver nanoparticles as a new generation of antimicrobials
Department of Biotechnology, SGB Amravati University, Amravati 444 602, Maharashtra, India
Biotechnol Adv 27:76-83. 2009
..Hence, silver nanoparticles have emerged up with diverse medical applications ranging from silver based dressings, silver coated medicinal devices, such as nanogels, nanolotions, etc...
- Renal clearance of quantum dots
Hak Soo Choi
Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Room SL B05, Boston, Massachusetts 02215, USA
Nat Biotechnol 25:1165-70. 2007
..5 nm resulted in rapid and efficient urinary excretion and elimination of quantum dots from the body. This study provides a foundation for the design and development of biologically targeted nanoparticles for biomedical applications...
- Size-dependent cytotoxicity of gold nanoparticles
Biomedical Engineering, Biointerface Laboratory, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany
Small 3:1941-9. 2007
..The cellular response is size dependent, in that 1.4-nm particles cause predominantly rapid cell death by necrosis within 12 h while closely related particles 1.2 nm in diameter effect predominantly programmed cell death by apoptosis...
- Nanoparticle-mediated cellular response is size-dependent
Nat Nanotechnol 3:145-50. 2008
..The findings presented here may assist in the design of nanoscale delivery and therapeutic systems and provide insights into nanotoxicity...
- Effect of surface properties on nanoparticle-cell interactions
Department of Materials Science and Engineering, Massachusetts Institute of Technology MIT, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
Small 6:12-21. 2010
..Challenges for undertaking a systematic study to elucidate nanoparticle-cell interactions are also discussed...
- Particle size-dependent organ distribution of gold nanoparticles after intravenous administration
Wim H De Jong
Laboratory for Health Protection Research, National Institute for Public Health and the Environment RIVM, Antonie van Leeuwenhoeklaan 9, Bilthoven, The Netherlands
Biomaterials 29:1912-9. 2008
A kinetic study was performed to determine the influence of particle size on the in vivo tissue distribution of spherical-shaped gold nanoparticles in the rat...
- Translocation of inhaled ultrafine particles to the brain
Department of Environmental Medicine, University of Rochester, Rochester, New York 14642, USA
Inhal Toxicol 16:437-45. 2004
..Depending on their particle size, inhaled UFP are efficiently deposited in nasal, tracheobronchial, and alveolar regions due to diffusion...
- Understanding the nanoparticle-protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles
School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland
Proc Natl Acad Sci U S A 104:2050-5. 2007
..The kinetic and equilibrium binding properties depend on protein identity as well as particle surface characteristics and size...
- Strategies in the design of nanoparticles for therapeutic applications
Robby A Petros
Department of Chemistry, University of North Texas, Denton, Texas 76203, USA
Nat Rev Drug Discov 9:615-27. 2010
..This Review focuses on recent progress important for the rational design of such nanoparticles and discusses the challenges to realizing the potential of nanoparticles...
- Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration
Laboratory for Bio Environmental Effects of Nanomaterials and Nanosafety and Key Laboratory of Nuclear Analytical Techniques, National Center for NanoScience and Technology and Institute of High Energy Physics, Beijing 100080, PR China
Toxicol Lett 168:176-85. 2007
..Biodistribution experiment showed that TiO(2) mainly retained in the liver, spleen, kidneys, and lung tissues, which indicated that TiO(2) particles could be transported to other tissues and organs after uptake by gastrointestinal tract...
- PVP-coated silver nanoparticles and silver ions induce reactive oxygen species, apoptosis and necrosis in THP-1 monocytes
Department of Environmental and Occupational Medicine, Institute of Public Health, Aarhus University, Bartholins Alle 2, Bygn 1260, 8000 Aarhus, Denmark
Toxicol Lett 190:156-62. 2009
..A drastic increase in ROS levels could be detected after 6-24h suggesting that oxidative stress is an important mediator of cytotoxicity caused by Ag NPs and Ag+...
- Factors affecting the clearance and biodistribution of polymeric nanoparticles
Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Mol Pharm 5:505-15. 2008
- A toxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors
Nicholas School of the Environment and Earth Sciences, Duke University, Durham, North Carolina 27708, USA
Environ Health Perspect 114:165-72. 2006
..Key words: environment, human health, nanomaterials, nanosized particles, nanotechnology, nanotoxicology, quantum dots, toxicology...
- Quantitative assessment of the comparative nanoparticle-uptake efficiency of a range of cell lines
Tiago Dos Santos
Centre for BioNano Interactions, School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland
Small 7:3341-9. 2011
..Here, the effect of particle size on the in-vitro intracellular uptake of model fluorescent carboxyl-modified polystyrene nanoparticles is ..
- Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles
State Key Laboratory of Genetic Engineering, Department of Pharmaceutical Sciences, School of Life Sciences, Fudan University, Shanghai 200433, China
Biomaterials 31:3657-66. 2010
To elucidate the effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles (NPs), rhodamine B (RhB) labeled carboxymethyl chitosan grafted NPs (RhB-CMCNP) and chitosan hydrochloride ..
- Curcumin and its nano-formulation: the kinetics of tissue distribution and blood-brain barrier penetration
Yin Meng Tsai
Institute of Traditional Medicine, National Yang Ming University, Taipei, Taiwan
Int J Pharm 416:331-8. 2011
..The mean particle size and entrapment efficiency were 163nm and 46.9%, respectively...
- Solid lipid nanoparticles: production, characterization and applications
Institute of Pharmacy, Department of Pharmaceutical Technology, Free University of Berlin, Kelchstr 31, D 12169, Berlin, Germany
Adv Drug Deliv Rev 47:165-96. 2001
..The use of several analytical techniques is a necessity. Alternative structures and dynamic phenomena on the molecular level have to be considered. Aspects of SLN administration and the in vivo fate of the carrier are discussed...
- Unique cellular interaction of silver nanoparticles: size-dependent generation of reactive oxygen species
Applied Biotechnology Branch, Human Effectiveness Directorate, Wright Patterson Air Force Base, Dayton, Ohio 45433, USA
J Phys Chem B 112:13608-19. 2008
..In summary, a size-dependent toxicity was produced by silver nanoparticles, and one predominant mechanism of toxicity was found to be largely mediated through oxidative stress...
- Influenza virus aerosols in human exhaled breath: particle size, culturability, and effect of surgical masks
Donald K Milton
Maryland Institute for Applied Environmental Health, University of Maryland School of Public Health, College Park, Maryland, United States of America
PLoS Pathog 9:e1003205. 2013
..Monitoring exhaled virus aerosols will be important for validation of experimental transmission studies in humans...
- Asbestos, carbon nanotubes and the pleural mesothelium: a review of the hypothesis regarding the role of long fibre retention in the parietal pleura, inflammation and mesothelioma
University of Edinburgh, Centre for Inflammation Research, Queens Medical Research Institute, 47 Little France Crescent, Edinburgh EH164TJ, UK
Part Fibre Toxicol 7:5. 2010
- A review of the in vivo and in vitro toxicity of silver and gold particulates: particle attributes and biological mechanisms responsible for the observed toxicity
Helinor J Johnston
Centre for Nano Safety, School of Life Sciences, Edinburgh Napier University, Edinburgh, UK
Crit Rev Toxicol 40:328-46. 2010
..Alternatively, a combination of both may be responsible, as the release of ions would be expected to be greater for smaller particles...
- Recent advances in iron oxide nanocrystal technology for medical imaging
Guerbet Research, BP 57400, 95943 Roissy CDG, France
Adv Drug Deliv Rev 58:1471-504. 2006
..Stem cell migration and immune cell trafficking, as well as targeted iron oxide nanoparticles for molecular imaging studies, are at the stage of proof of concept, mainly in animal models...
- Copper oxide nanoparticles are highly toxic: a comparison between metal oxide nanoparticles and carbon nanotubes
Hanna L Karlsson
Department of Biosciences and Nutrition at Novum, Karolinska Institutet, Stockholm, Sweden
Chem Res Toxicol 21:1726-32. 2008
..The effects were not explained by soluble metal impurities. In conclusion, this study highlights the in vitro toxicity of CuO nanoparticles...
- The effect of particle design on cellular internalization pathways
Stephanie E A Gratton
Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599, USA
Proc Natl Acad Sci U S A 105:11613-8. 2008
The interaction of particles with cells is known to be strongly influenced by particle size, but little is known about the interdependent role that size, shape, and surface chemistry have on cellular internalization and intracellular ..
- Calculated absorption and scattering properties of gold nanoparticles of different size, shape, and composition: applications in biological imaging and biomedicine
Prashant K Jain
Laser Dynamics Laboratory, School of Chemistry and Biochemistry, Georgia, Institute of Technology, Atlanta, Georgia 30332 0400, USA
J Phys Chem B 110:7238-48. 2006
- Stability and aggregation of metal oxide nanoparticles in natural aqueous matrices
Arturo A Keller
University of California, Santa Barbara, USA
Environ Sci Technol 44:1962-7. 2010
..8 microm s(-1) V(-1) cm. These results are key for designing and interpreting nanoparticle ecotoxicity studies in various environmental conditions...
- In vitro models of the human epithelial airway barrier to study the toxic potential of particulate matter
University of Bern, Institute of Anatomy, Division of Histology, Baltzerstrasse 2, CH 3000 Bern 9, Switzerland
Expert Opin Drug Metab Toxicol 4:1075-89. 2008
..Of particular interest are the ultrafine particles that are particularly toxic. In addition more and more nanoparticles are released into the environment; however, the potential health effects of these nanoparticles are yet unknown...
- The effect of particle size on the cytotoxicity, inflammation, developmental toxicity and genotoxicity of silver nanoparticles
Margriet V D Z Park
Department of Toxicogenomics, Maastricht University, 6200 MD Maastricht, The Netherlands
Biomaterials 32:9810-7. 2011
..The most pronounced effect of silver nanoparticles and the role of particle size in determining these effects, also in comparison to silver ions, are largely unknown...
- Role of target geometry in phagocytosis
Julie A Champion
Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA
Proc Natl Acad Sci U S A 103:4930-4. 2006
..Failure to create the required actin structure results in simple spreading and not internalization. Particle size primarily impacts the completion of phagocytosis in cases where particle volume exceeds the cell volume.
- Development of glycyrrhetinic acid-modified stealth cationic liposomes for gene delivery
Zhi Yao He
West China School of Pharmacy, Sichuan University, Chengdu, Sichuan 610041, PR China
Int J Pharm 397:147-54. 2010
..In conclusion, GA-PEG-CLs containing 5% GA-PEG-Chol might be one of the most potential gene vectors as hepatoma targeting therapy...
- Cause-specific mortality and the extended effects of particulate pollution and temperature exposure
Patrick G Goodman
School of Physics, Dublin Institute of Technology, and St James Hospital, Dublin, Ireland
Environ Health Perspect 112:179-85. 2004
..This analysis suggests that studies on the acute effects of air pollution have underestimated the total effects of temperature and particulate air pollution on mortality...
- Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution
C Arden Pope
Department of Economics, Brigham Young University, 142 FOB, Provo, UT 84602, USA
JAMA 287:1132-41. 2002
..However, studies of health effects of long-term particulate air pollution have been less conclusive...
- Nanomedicine: current status and future prospects
S Moein Moghimi
Molecular Targeting and Polymer Toxicology Group, School of Pharmacy, University of Brighton, Brighton, UK
FASEB J 19:311-30. 2005
..Potential pitfalls or side effects associated with nanoparticles are also discussed...
- Cytotoxicity of nanoparticles independent from oxidative stress
Center for Medical Research, Medical University of Graz, A 8010 Graz, Austria
J Toxicol Sci 34:363-75. 2009
..Protein containing solutions led to increases in particle size, decreased cytotoxicity and reduced cellular uptake...
- Preparation and evaluation of self-microemulsifying drug delivery system of oridonin
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 210203, PR China
Int J Pharm 355:269-76. 2008
..The absorption of oridonin from SMEDDS showed a 2.2-fold increase in relative bioavailability compared with that of the suspension. Our studies demonstrated the promising use of SMEDDS for the delivery of oridonin by the oral route...
- Cellular responses induced by silver nanoparticles: In vitro studies
Centre for Nanobioscience, Agharkar Research Institute, G G Agarkar Road, Pune 411004, India
Toxicol Lett 179:93-100. 2008
..5 microg/mL in both cell types). These results can be used to define a safe range of SNP for the intended application as a topical antimicrobial agent after appropriate in vivo studies...
- Chemistry and properties of nanocrystals of different shapes
Center for Chemical Dynamics and Nanomaterials Research, Department of Chemistry, Case Western Reserve University Millis 2258, Cleveland, Ohio 44106, USA
Chem Rev 105:1025-102. 2005
- Acute toxicity and pharmacokinetics of 13 nm-sized PEG-coated gold nanoparticles
Wan Seob Cho
Division of Toxicologic Pathology, Department of Toxicological Research, National Institute of Toxicological Research, Korea Food and Drug Administration, 231 Jinhoungno Eunpyung ku, Seoul 122 704, Republic of Korea
Toxicol Appl Pharmacol 236:16-24. 2009
..These findings of toxicity and kinetics of PEG-coated gold nanoparticles may have important clinical implications regarding the safety issue as PEG-coated gold nanoparticles are widely used in biomedical applications...
- Time evolution of the nanoparticle protein corona
Institut Catala de Nanotecnologia, Bellaterra, Barcelona, Spain
ACS Nano 4:3623-32. 2010
..Mass spectrometry of the digested protein corona revealed albumin as the most abundant component which suggests an improved biocompatibility...
- Effects of cell culture media on the dynamic formation of protein-nanoparticle complexes and influence on the cellular response
Italian Institute of Technology, Center for Bio Molecular Nanotechnology, Via Barsanti 73010 Arnesano, Lecce, Italy
ACS Nano 4:7481-91. 2010
..These results show that, beyond an in-depth NPs characterization before cellular experiments, a detailed understanding of the effects elicited by cell culture media on NPs is crucial for standardized nanotoxicology tests...
- Uptake and intracellular fate of surface-modified gold nanoparticles
Department of Chemistry, University of Liverpool, Liverpool, United Kingdom
ACS Nano 2:1639-44. 2008
..Successful nuclear targeting is demonstrated using surface modification with a cocktail of CPPs and a peptide acting as a nuclear localization signal (NLS)...
- Clearance properties of nano-sized particles and molecules as imaging agents: considerations and caveats
Molecular Imaging Program, NCI NIH Building 10, Bethesda, MD 20892 1088, USA
Nanomedicine (Lond) 3:703-17. 2008
- Size-dependent cytotoxicity of amorphous silica nanoparticles in human hepatoma HepG2 cells
Department of Toxicology, School of Public Health, Jilin University, Changchun, Jilin 130021, PR China
Toxicol In Vitro 25:1343-52. 2011
..results indicated that in HepG2 cells, the cytotoxicity generated by silica particles strongly depended on the particle size, and smaller silica particle possessed higher toxic effect...
- The nanosilica hazard: another variable entity
Unit of Lung Toxicology, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium
Part Fibre Toxicol 7:39. 2010
- Medical application of functionalized magnetic nanoparticles
Department of Biotechnology, School of Engineering, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8603, Japan
J Biosci Bioeng 100:1-11. 2005
..Thus, the applications of these functionalized magnetic nanoparticles with their unique features will further improve medical techniques...
- Mediating tumor targeting efficiency of nanoparticles through design
Steven D Perrault
Institute of Biomaterials and Biomedical Engineering, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, ON, M5S 3E1, Canada
Nano Lett 9:1909-15. 2009
..Our results provide design parameters for engineering nanoparticles for optimized tumor targeting of contrast agents and therapeutics...
- Shape effects of filaments versus spherical particles in flow and drug delivery
NanoBioPolymers and Molecular and Cell Biophysics Lab, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Nat Nanotechnol 2:249-55. 2007
..Although these findings show that long-circulating vehicles need not be nanospheres, they also lend insight into possible shape effects of natural filamentous viruses...
- Impact of silver nanoparticles on human cells: effect of particle size
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing, China
Nanotoxicology 4:319-30. 2010
..The findings may assist in the design of SNP applications and provide insights into their toxicity...
- Silver nanoparticles induce cytotoxicity by a Trojan-horse type mechanism
Eun Jung Park
College of Pharmacy, Dongduk Women s University, 23 1 Wolgok Dong, Seongbuk gu, Seoul 136 714, Republic of Korea
Toxicol In Vitro 24:872-8. 2010
..It seemed that AgNPs were ionized in the cells to cause cytotoxicity by a Trojan-horse type mechanism suggested by previously reported studies...
- Galactosylated poly(ethylene glycol)-chitosan-graft-polyethylenimine as a gene carrier for hepatocyte-targeting
Hu Lin Jiang
Department of Agricultural Biotechnology, Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 151 921, South Korea
J Control Release 131:150-7. 2008
..composition of Gal-PEG-CHI-g-PEI was characterized using (1)H nuclear magnetic resonance ((1)H NMR), and the particle size and zeta potential of Gal-PEG-CHI-g-PEI/DNA complexes were measured using dynamic light scattering (DLS)...
- Respiratory health effects of airborne particulate matter: the role of particle size, composition, and oxidative potential-the RAPTES project
National Institute for Public Health and the Environment RIVM, Bilthoven, Netherlands
Environ Health Perspect 120:1183-9. 2012
..High correlations among, and differential measurement errors of, individual components contribute to this uncertainty...
- Woodsmoke health effects: a review
Luke P Naeher
Department of Environmental Health Science, College of Public Health, University of Georgia, Athens, Georgia, USA
Inhal Toxicol 19:67-106. 2007
..In addition, we provide recommendations for additional woodsmoke research...
- Health effects of fine particulate air pollution: lines that connect
C Arden Pope
Department of Economics, Brigham Young University, Provo, UT 84602 2363, USA
J Air Waste Manag Assoc 56:709-42. 2006
- Silver colloid nanoparticles: synthesis, characterization, and their antibacterial activity
Department of Physical Chemistry, Palacky University, Svobody 26, 771 46 Olomouc, Czech Republic
J Phys Chem B 110:16248-53. 2006
..Antibacterial activity of silver nanoparticles was found to be dependent on the size of silver particles. A very low concentration of silver (as low as 1.69 mug/mL Ag) gave antibacterial performance...
- Characterization of nanoparticle uptake by endothelial cells
Department of Pharmaceutical Sciences, College of Pharmacy, 986025 Nebraska Medical Center, Omaha, NE 68198 6025, USA
Int J Pharm 233:51-9. 2002
..Nanoparticles localized in the endothelium could provide prolonged drug effects because of their sustained release characterics, and also could protect the encapsulated agent from enzymatic degradation...
- Surface-structure-regulated cell-membrane penetration by monolayer-protected nanoparticles
Department of Materials Science and Engineering, MIT, Massachusetts 02139, USA
Nat Mater 7:588-95. 2008
..Our results offer a paradigm for analysing the fundamental problem of cell-membrane-penetrating bio- and macro-molecules...
- Polymer-based nanocapsules for drug delivery
C E Mora-Huertas
Universite de Lyon, F 69622, Lyon, France
Int J Pharm 385:113-42. 2010
..Consequently, the information obtained allows establishing criteria for selecting a method for preparation of nanocapsules according to its advantages, limitations and behaviours as a drug carrier...
- A novel exposure system for the efficient and controlled deposition of aerosol particles onto cell cultures
Institute of Anatomy, University of Bern, Bern, Switzerland
Environ Sci Technol 42:5667-74. 2008
..In situ analyses of the lung cells, e.g., the ciliary beat frequency, indicative of the defense capability of the cells, are complemented by off-line biochemical, physiological, and morphological cell analyses...
- A high-performance nanobio photocatalyst for targeted brain cancer therapy
Elena A Rozhkova
The Center for Nanoscale Materials, Argonne National Laboratory, Argonne, Illinois 60439, USA
Nano Lett 9:3337-42. 2009
..Synchrotron X-ray fluorescence microscopy (XFM) was applied for direct visualization of the nanobioconjugate distribution through a single brain cancer cell at the submicrometer scale...
- Endocytosis at the nanoscale
The Krebs Institute, The Centre for Membrane Interaction and Dynamics, The Sheffield Cancer Research Centre, and the Department of Biomedical Science, The University of Sheffield, Western Bank, Sheffield, S10 2TN, UK
Chem Soc Rev 41:2718-39. 2012
..Finally, we discuss different drug delivery strategies on how to evade lysosomal degradation to promote effective release of the cargo (376 references)...
- Residual polyvinyl alcohol associated with poly (D,L-lactide-co-glycolide) nanoparticles affects their physical properties and cellular uptake
Sanjeeb K Sahoo
Department of Pharmaceutical Sciences, University of Nebraska Medical Center 986025, Omaha, NE 68198 6025, USA
J Control Release 82:105-14. 2002
..The residual PVA, in turn, influenced different pharmaceutical properties of nanoparticles such as particle size, zeta potential, polydispersity index, surface hydrophobicity, protein loading and also slightly influenced ..
- The effect of sedimentation and diffusion on cellular uptake of gold nanoparticles
Eun Chul Cho
Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
Nat Nanotechnol 6:385-91. 2011
..Our results suggest that sedimentation needs to be considered when performing in vitro studies for large and/or heavy nanoparticles...
- Cellular uptake, cytotoxicity, and innate immune response of silica-titania hollow nanoparticles based on size and surface functionality
Wan Kyu Oh
School of Chemical and Biological Engineering, Seoul National University, 599 Gwanangro, Gwanak Gu, Seoul 151 742, Korea
ACS Nano 4:5301-13. 2010
..These findings provide size- and surface functionality-dependent nanotoxicity and uptake of HNPs, and lead to HNPs for bioapplications such as drug delivery and imaging probe...
- Evaluating the uptake and intracellular fate of polystyrene nanoparticles by primary and hepatocyte cell lines in vitro
Helinor J Johnston
Biomedicine and Sport and Exercise Science Research Group, School of Life Sciences, Edinburgh Napier University, Edinburgh EH10 5DT, UK
Toxicol Appl Pharmacol 242:66-78. 2010
..The findings were, in the main, comparable between primary rat hepatocytes and the different human hepatocyte cell lines...
- Characterization of nanomaterial dispersion in solution prior to in vitro exposure using dynamic light scattering technique
Richard C Murdock
Applied Biotechnology Branch, Human Effectiveness Directorate Air Force Research Laboratory HEPB, Wright Patterson Air Force Board, Ohio 45433, USA
Toxicol Sci 101:239-53. 2008
The need to characterize nanoparticles in solution before assessing the in vitro toxicity is a high priority. Particle size, size distribution, particle morphology, particle composition, surface area, surface chemistry, and particle ..
- Surface-modified superparamagnetic nanoparticles for drug delivery: preparation, characterization, and cytotoxicity studies
Ajay Kumar Gupta
Centre for Cell Engineering, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
IEEE Trans Nanobioscience 3:66-73. 2004
- Silica and titanium dioxide nanoparticles cause pregnancy complications in mice
Department of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565 0871, Japan
Nat Nanotechnol 6:321-8. 2011
..These detrimental effects are linked to structural and functional abnormalities in the placenta on the maternal side, and are abolished when the surfaces of the silica nanoparticles are modified with carboxyl and amine groups...
- Time-series analysis of mortality effects of fine particulate matter components in Detroit and Seattle
New York University School of Medicine, Tuxedo, New York 10987, USA
Environ Health Perspect 119:461-6. 2011
..Recent toxicological and epidemiological studies have shown associations between particulate matter (PM) and adverse health effects, but which PM components are most influential is less well known...
- The kinetics of the tissue distribution of silver nanoparticles of different sizes
D P K Lankveld
Laboratory for Health Protection Research, National Institute for Public Health and the Environment RIVM, PO Box 1, 3720 BA Bilthoven, The Netherlands
Biomaterials 31:8350-61. 2010
..Model parameter values were estimated by fitting to data. No clear relation between parameter values and corresponding particle diameters became apparent...
- Optimization and characterization of anionic lipoplexes for gene delivery
Department of Pharmaceutical Sciences, University of Connecticut, 69 North Eagleville Road, Unit 3092, Storrs, CT 06269, USA
J Control Release 136:62-70. 2009
..8 microg plasmid DNA. Biophysical studies (particle size analysis, gel electrophoresis, transmission electron microscopy (TEM), and confocal microscopy) were conducted ..
- Biodistribution of colloidal gold nanoparticles after intravenous administration: effect of particle size
Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, Japan
Colloids Surf B Biointerfaces 66:274-80. 2008
..Another objective was to study effect of particle size on biological distribution of gold NP to enable their diverse applications in nanotechnology...
- Nanocarriers' entry into the cell: relevance to drug delivery
School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA
Cell Mol Life Sci 66:2873-96. 2009
..Nevertheless, various strategies are being actively investigated in order to tailor nanocarriers able to deliver anticancer agents, nucleic acids, proteins and peptides for therapeutic applications by these non-phagocytic routes...
- Particle size, surface coating, and PEGylation influence the biodistribution of quantum dots in living mice
Meike L Schipper
Molecular Imaging Program at Stanford MIPS, Department of Radiology, Bio X Program, Stanford University, 318 Campus Drive, Palo Alto, CA 94305 5427, USA
Small 5:126-34. 2009
This study evaluates the influence of particle size, PEGylation, and surface coating on the quantitative biodistribution of near-infrared-emitting quantum dots (QDs) in mice...
- Effects of prenatal exposure to surface-coated nanosized titanium dioxide (UV-Titan). A study in mice
Karin S Hougaard
National Research Centre for the Working Environment, Copenhagen Ø, Denmark
Part Fibre Toxicol 7:16. 2010
..Consequently, also toxicological properties may change compared to the parent compound. We examined developmental and neurobehavioral effects following maternal exposure to a nanoparticulate UV-filter (UV-titan L181)...
- Fine particulate matter constituents associated with cardiovascular hospitalizations and mortality in New York City
New York University School of Medicine, Tuxedo, New York 10987, USA
Environ Health Perspect 119:467-73. 2011
..We investigated this issue in New York City (NYC), where PM originates from regional and local combustion sources...
- Spatial and temporal variation in PM(2.5) chemical composition in the United States for health effects studies
Michelle L Bell
School of Forestry and Environmental Studies, Yale University, New Haven, Connecticut, USA
Environ Health Perspect 115:989-95. 2007
..Although numerous studies have demonstrated links between particulate matter (PM) and adverse health effects, the chemical components of the PM mixture that cause injury are unknown...
- In vitro toxicity of silica nanoparticles in human lung cancer cells
Department of Chemistry and Environmental Research Center, University of Missouri Rolla, Rolla, MO 65409, USA
Toxicol Appl Pharmacol 217:252-9. 2006
..In summary, exposure to SiO(2) nanoparticles results in a dose-dependent cytotoxicity in cultural human bronchoalveolar carcinoma-derived cells that is closely correlated to increased oxidative stress...
- Large porous particles for pulmonary drug delivery
D A Edwards
Department of Chemical Engineering, Pennsylvania State University, 204 Fenske Laboratory, University Park, PA 16802, USA
Science 276:1868-71. 1997
..High systemic bioavailability of testosterone was also achieved by inhalation delivery of porous particles with a mean diameter (20 micrometers) approximately 10 times that of conventional inhaled therapeutic particles...
- Oxide nanoparticle uptake in human lung fibroblasts: effects of particle size, agglomeration, and diffusion at low concentrations
Ludwig K Limbach
Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zurich, Switzerland
Environ Sci Technol 39:9370-6. 2005
..but physiologically relevant concentrations reveal a strong dependence of the amount of incorporated ceria on particle size, while nanoparticle number density or total particle surface area are of minor importance...
- Mechanics of receptor-mediated endocytosis
Max Planck Institute for Metals Research, Heisenbergstrasse 3, D 70569 Stuttgart, Germany
Proc Natl Acad Sci U S A 102:9469-74. 2005
..This model can also be extended to include the effect of clathrin coat. The results seem to show broad agreement with experimental observations...
- Paclitaxel-loaded PEGylated PLGA-based nanoparticles: in vitro and in vivo evaluation
Universite Catholique de Louvain, Unite de Pharmacie Galenique, Avenue Mounier, 73 20, 1200 Brussels, Belgium
J Control Release 133:11-7. 2009
..Therefore, PTX-loaded nanoparticles may be considered as an effective anticancer drug delivery system for cancer chemotherapy...
- The effect of fine and coarse particulate air pollution on mortality: a national analysis
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
Environ Health Perspect 117:898-903. 2009
..5) and PM coarse on the increased risk of death for all causes, cardiovascular disease (CVD), myocardial infarction (MI), stroke, and respiratory mortality for the years 1999-2005...
- Protein adsorption and cellular uptake of cerium oxide nanoparticles as a function of zeta potential
Advanced Materials Processing and Analysis Center, Department of Mechanical, Materials and Aerospace Engineering, University of Central Florida, Orlando, FL 32816, USA
Biomaterials 28:4600-7. 2007
..These results demonstrate that electrostatic interactions can play an important factor in protein adsorption and cellular uptake of nanoparticles...
- Influence of apolipoprotein (Apo) A-I structure on nascent high density lipoprotein (HDL) particle size distribution
Lipid Research Group, Gastroenterology, Hepatology, and Nutrition Division, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4318, USA
J Biol Chem 285:31965-73. 2010
..The stability of the apoA-I N-terminal helix bundle domain and the hydrophobicity of the C-terminal domain are important determinants of both nascent HDL particle size and their rate of formation.
- Ceramic-based nanoparticles entrapping water-insoluble photosensitizing anticancer drugs: a novel drug-carrier system for photodynamic therapy
Institute of Lasers, Photonics and Biophotonics, Department of Chemistry, State University of New York, Buffalo, NY 14260 3000, USA
J Am Chem Soc 125:7860-5. 2003
..Significant damage to such impregnated tumor cells was observed upon irradiation with light of wavelength 650 nm. Thus, the potential of using ceramic-based nanoparticles as drug carriers for photodynamic therapy has been demonstrated...
- Size-dependency of nanoparticle-mediated gene transfection: studies with fractionated nanoparticles
Department of Pharmaceutical Sciences, 986025 University of Nebraska Medical Center, Omaha, NE 68198 6025, USA
Int J Pharm 244:105-15. 2002
..The results suggest that the particle size is an important factor, and that the smaller-sized fraction of the nanoparticle formulation predominantly ..
- Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size
Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Hongo, Bunkyo ku, Japan
Nat Nanotechnol 6:815-23. 2011
..We also showed that the penetration and efficacy of the larger micelles could be enhanced by using a transforming growth factor-β inhibitor to increase the permeability of the tumours...
- Ambient air pollution and low birth weight in Connecticut and Massachusetts
Michelle L Bell
School of Forestry and Environmental Studies, Yale University, New Haven, Connecticut 06511, USA
Environ Health Perspect 115:1118-24. 2007
..Several studies have examined whether air pollution affects birth weight; however results vary and many studies were focused on Southern California or were conducted outside of the United States...
- Circulating microparticles: pathophysiology and clinical implications
Irish Blood Transfusion Service, James s Street, Dublin 8, Ireland
Blood Rev 21:157-71. 2007
..In addition the complex role of microparticles in vascular and cardiovascular diseases is an area of immense interest, that promises to yield important advances into diagnosis and therapy...
- Chronic fine and coarse particulate exposure, mortality, and coronary heart disease in the Nurses' Health Study
ROBIN C PUETT
South Carolina Cancer Prevention and Control Program and Department of Epidemiology, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina 29201, USA
Environ Health Perspect 117:1697-701. 2009
..5 and 10 microm (PM(10-2.5)), may also be important. With respect to mortality and cardiovascular events, questions remain regarding the relative strength of effect sizes for chronic exposure to fine and coarse particles...
- The impact of polycyclic aromatic hydrocarbons and fine particles on pregnancy outcome
Laboratory of Genetic Ecotoxicology, Regional Institute of Hygiene of Central Bohemia and Institute of Experimental Medicine, Academy of Science of the Czech Republic, Prague, Czech Republic
Environ Health Perspect 108:1159-64. 2000
..The results prove that exposure to c-PAHs in early gestation may influence fetal growth. The particulate matter-IUGR association observed earlier may be at least partly explained by the presence of c-PAHs on particle surfaces...