nucleic acid conformation

Summary

Summary: The spatial arrangement of the atoms of a nucleic acid or polynucleotide that results in its characteristic 3-dimensional shape.

Top Publications

  1. ncbi WebLogo: a sequence logo generator
    Gavin E Crooks
    Department of Plant and Microbial Biology, University of California, Berkeley, California 94720, USA
    Genome Res 14:1188-90. 2004
  2. ncbi Mfold web server for nucleic acid folding and hybridization prediction
    Michael Zuker
    Department of Mathematical Sciences, Rensselaer Polytechnic Institute, Troy, NY 12180, USA
    Nucleic Acids Res 31:3406-15. 2003
  3. ncbi Real-time quantification of microRNAs by stem-loop RT-PCR
    Caifu Chen
    Applied Biosystems, 850 Lincoln Centre Drive, Foster City, CA 94404, USA
    Nucleic Acids Res 33:e179. 2005
  4. ncbi Crystal structure of the nucleosome core particle at 2.8 A resolution
    K Luger
    Institut fur Molekularbiologie und Biophysik, Zurich, Switzerland
    Nature 389:251-60. 1997
  5. ncbi Infernal 1.0: inference of RNA alignments
    Eric P Nawrocki
    HHMI Janelia Farm Research Campus, Ashburn, VA 20147, USA
    Bioinformatics 25:1335-7. 2009
  6. ncbi Architecture and secondary structure of an entire HIV-1 RNA genome
    Joseph M Watts
    Department of Chemistry, University of North Carolina, Chapel Hill, North Carolina 27599 3290, USA
    Nature 460:711-6. 2009
  7. ncbi A bivalent chromatin structure marks key developmental genes in embryonic stem cells
    Bradley E Bernstein
    Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Cell 125:315-26. 2006
  8. ncbi The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
    R C Lee
    Harvard University, Department of Cellular and Developmental Biology, Cambridge, Massachusetts 02138
    Cell 75:843-54. 1993
  9. ncbi The role of site accessibility in microRNA target recognition
    Michael Kertesz
    Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot 76100, Israel
    Nat Genet 39:1278-84. 2007
  10. ncbi Computational identification of plant microRNAs and their targets, including a stress-induced miRNA
    Matthew W Jones-Rhoades
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA
    Mol Cell 14:787-99. 2004

Research Grants

  1. STRUCTURE OF VIRAL RNA AND ITS ROLE IN ASSEMBLY
    Alexander McPherson; Fiscal Year: 2006
  2. X RAY STUDIES OF NUCLEIC ACID CONSTITUENTS
    Muttaiya Sundaralingam; Fiscal Year: 2001
  3. BIOCHEMICAL MECHANISM OF EXOCYCLIC ADDUCTS IN CANCER
    Bo Hang; Fiscal Year: 2004
  4. DNA/RNA Quadruplexes: Structure, Stability, Interactions
    RICHARD SHAFER; Fiscal Year: 2006
  5. NUCLEIC ACID CONFORMATION, PROPERTIES, AND INTERACTIONS
    WILMA OLSON; Fiscal Year: 1980
  6. Acquisition of a Circular Dichroism Spectrometer
    Barbara Brodsky; Fiscal Year: 2002
  7. NUCLEIC ACID CONFORMATION, PROPERTIES, AND INTERACTIONS
    WILMA OLSON; Fiscal Year: 2006
  8. NUCLEIC ACID CONFORMATION, PROPERTIES, AND INTERACTIONS
    WILMA OLSON; Fiscal Year: 2001
  9. Nanomedicine Center for Protein Deposition Diseases(RMI)
    Yuri Lyubchenko; Fiscal Year: 2004
  10. CONFORMATIONAL PROPERTIES OF DNA CATENANES
    Alexander Vologodskii; Fiscal Year: 2006

Detail Information

Publications238 found, 100 shown here

  1. ncbi WebLogo: a sequence logo generator
    Gavin E Crooks
    Department of Plant and Microbial Biology, University of California, Berkeley, California 94720, USA
    Genome Res 14:1188-90. 2004
    ..A command line interface and the complete, open WebLogo source code are available for local installation and customization...
  2. ncbi Mfold web server for nucleic acid folding and hybridization prediction
    Michael Zuker
    Department of Mathematical Sciences, Rensselaer Polytechnic Institute, Troy, NY 12180, USA
    Nucleic Acids Res 31:3406-15. 2003
    ..The portal for the mfold web server is http://www.bioinfo.rpi.edu/applications/mfold. This URL will be referred to as 'MFOLDROOT'...
  3. ncbi Real-time quantification of microRNAs by stem-loop RT-PCR
    Caifu Chen
    Applied Biosystems, 850 Lincoln Centre Drive, Foster City, CA 94404, USA
    Nucleic Acids Res 33:e179. 2005
    ..Furthermore, the concept of stem-loop RT primer design could be applied in small RNA cloning and multiplex assays for better specificity and efficiency...
  4. ncbi Crystal structure of the nucleosome core particle at 2.8 A resolution
    K Luger
    Institut fur Molekularbiologie und Biophysik, Zurich, Switzerland
    Nature 389:251-60. 1997
    ..The lack of uniformity between multiple histone/DNA-binding sites causes the DNA to deviate from ideal superhelix geometry...
  5. ncbi Infernal 1.0: inference of RNA alignments
    Eric P Nawrocki
    HHMI Janelia Farm Research Campus, Ashburn, VA 20147, USA
    Bioinformatics 25:1335-7. 2009
    ..janelia.org. INFERNAL is freely licensed under the GNU GPLv3 and should be portable to any POSIX-compliant operating system, including Linux and Mac OS/X...
  6. ncbi Architecture and secondary structure of an entire HIV-1 RNA genome
    Joseph M Watts
    Department of Chemistry, University of North Carolina, Chapel Hill, North Carolina 27599 3290, USA
    Nature 460:711-6. 2009
    ..These results emphasize that the HIV-1 genome and, potentially, many coding RNAs are punctuated by previously unrecognized regulatory motifs and that extensive RNA structure constitutes an important component of the genetic code...
  7. ncbi A bivalent chromatin structure marks key developmental genes in embryonic stem cells
    Bradley E Bernstein
    Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Cell 125:315-26. 2006
    ..These results highlight the importance of DNA sequence in defining the initial epigenetic landscape and suggest a novel chromatin-based mechanism for maintaining pluripotency...
  8. ncbi The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
    R C Lee
    Harvard University, Department of Cellular and Developmental Biology, Cambridge, Massachusetts 02138
    Cell 75:843-54. 1993
    ..elegans and found to contain sequences complementary to a repeated sequence element in the 3' untranslated region (UTR) of lin-14 mRNA, suggesting that lin-4 regulates lin-14 translation via an antisense RNA-RNA interaction...
  9. ncbi The role of site accessibility in microRNA target recognition
    Michael Kertesz
    Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot 76100, Israel
    Nat Genet 39:1278-84. 2007
    ..Our study thus demonstrates that target accessibility is a critical factor in microRNA function...
  10. ncbi Computational identification of plant microRNAs and their targets, including a stress-induced miRNA
    Matthew W Jones-Rhoades
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA
    Mol Cell 14:787-99. 2004
    ..The expression of miR395, the sulfurylase-targeting miRNA, increases upon sulfate starvation, showing that miRNAs can be induced by environmental stress...
  11. ncbi RNAstructure: software for RNA secondary structure prediction and analysis
    Jessica S Reuter
    Department of Biochemistry and Biophysics and Center for RNA Biology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 712, Rochester, NY 14642, USA
    BMC Bioinformatics 11:129. 2010
    ..RNA secondary structure prediction, using thermodynamics, can be used to develop hypotheses about the structure of an RNA sequence...
  12. ncbi Genome-wide measurement of RNA secondary structure in yeast
    Michael Kertesz
    Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot 76100, Israel
    Nature 467:103-7. 2010
    ..PARS is readily applicable to other organisms and to profiling RNA structure in diverse conditions, thus enabling studies of the dynamics of secondary structure at a genomic scale...
  13. ncbi VARNA: Interactive drawing and editing of the RNA secondary structure
    Kévin Darty
    LRI, UMR CNRS 8623, UMR CNRS 8621, Universite Paris Sud 11, F91405 Orsay Cedex, France
    Bioinformatics 25:1974-5. 2009
    ..AVAILABILITY: VARNA is a free software, released under the terms of the GPLv3.0 license and available at http://varna.lri.fr. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online...
  14. ncbi Translation efficiency is determined by both codon bias and folding energy
    Tamir Tuller
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 107:3645-50. 2010
    ....
  15. ncbi X-ray solution scattering (SAXS) combined with crystallography and computation: defining accurate macromolecular structures, conformations and assemblies in solution
    Christopher D Putnam
    Ludwig Institute for Cancer Research, La Jolla, CA, USA
    Q Rev Biophys 40:191-285. 2007
    ....
  16. ncbi The transcriptionally active regions in the genome of Bacillus subtilis
    Simon Rasmussen
    Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark
    Mol Microbiol 73:1043-57. 2009
    ..One of the genes having this tail is efeN, which encodes a target of the twin-arginine translocase (Tat) protein translocation system...
  17. ncbi The structural and functional diversity of metabolite-binding riboswitches
    Adam Roth
    Howard Hughes Medical Institute, Yale University, New Haven, CT 06520 8103, USA
    Annu Rev Biochem 78:305-34. 2009
    ..This diverse set of metabolite-sensing RNAs is found to exploit a variety of distinct mechanisms to regulate genes that are fundamental to metabolism...
  18. ncbi A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA
    G Hutvagner
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Science 293:834-8. 2001
    ..Thus, the RNA interference and stRNA pathways intersect. Both pathways require the RNA-processing enzyme Dicer to produce the active small-RNA component that represses gene expression...
  19. ncbi RNAalifold: improved consensus structure prediction for RNA alignments
    Stephan H Bernhart
    Department of Computer Science, University of Leipzig, Leipzig, Germany
    BMC Bioinformatics 9:474. 2008
    ..In recent years, several alternative approaches have been advocated, pointing to several shortcomings of the original RNAalifold approach...
  20. ncbi Identification of novel genes coding for small expressed RNAs
    M Lagos-Quintana
    Department of Cellular Biochemistry, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, , Germany
    Science 294:853-8. 2001
    ..This suggests that sequence-specific, posttranscriptional regulatory mechanisms mediated by small RNAs are more general than previously appreciated...
  21. ncbi Prediction of RNA secondary structure using generalized centroid estimators
    Michiaki Hamada
    Mizuho Information and Research Institute, Inc, 2 3 Kanda Nishikicho, Chiyoda ku, Tokyo 101 8443, Japan
    Bioinformatics 25:465-73. 2009
    ..However, there is room for improvement in the objective functions presented in previous studies, which are maximized in the posterior decoding with respect to the accuracy measures for secondary structures...
  22. ncbi Structural basis of gate-DNA breakage and resealing by type II topoisomerases
    Ivan Laponogov
    Randall Division of Cell and Molecular Biophysics, King s College London, London, United Kingdom
    PLoS ONE 5:e11338. 2010
    ....
  23. ncbi Dissecting the influence of Mg2+ on 3D architecture and ligand-binding of the guanine-sensing riboswitch aptamer domain
    Janina Buck
    Institute for Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe University, Max von Laue Strasse 7 and 9, 60438 Frankfurt am Main, Germany
    Nucleic Acids Res 38:4143-53. 2010
    ..We propose that reduction of conformational dynamics in remote regions of the riboswitch aptamer domain is the minimal pre-requisite to pre-organize the core region for specific ligand binding...
  24. ncbi High-throughput SHAPE analysis reveals structures in HIV-1 genomic RNA strongly conserved across distinct biological states
    Kevin A Wilkinson
    Department of Chemistry, University of North Carolina, Chapel Hill, North Carolina, United States of America
    PLoS Biol 6:e96. 2008
    ..High-throughput SHAPE reveals a comprehensive view of HIV-1 RNA genome structure, and further application of this technology will make possible newly informative analysis of any RNA in a cellular transcriptome...
  25. ncbi RNA chaperones, RNA annealers and RNA helicases
    Lukas Rajkowitsch
    Max F Perutz Laboratories, University of Vienna, Vienna, Austria
    RNA Biol 4:118-30. 2007
    ..Finally, we present a new website for proteins with RNA chaperone activity which compiles all the information on these proteins with the perspective to promote the understanding of their activity...
  26. ncbi Genome-wide high-resolution mapping of exosome substrates reveals hidden features in the Arabidopsis transcriptome
    Julia A Chekanova
    School of Biological Sciences, University of Missouri Kansas City, Kansas City, MO 64110, USA
    Cell 131:1340-53. 2007
    ..These first genome-wide maps of exosome substrates will aid in illuminating new fundamental components and regulatory mechanisms of eukaryotic transcriptomes...
  27. ncbi Improved RNA secondary structure prediction by maximizing expected pair accuracy
    Zhi John Lu
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, New York 14642, USA
    RNA 15:1805-13. 2009
    ..Using MaxExpect, the average PPV of optimal structure is improved from 66% to 68% at the same sensitivity level (73%) compared with free energy minimization...
  28. ncbi microRNA target predictions in animals
    Nikolaus Rajewsky
    Center for Comparative Functional Genomics Department of Biology, 100 Washington Square East, New York, New York 10003, USA
    Nat Genet 38:S8-13. 2006
    ....
  29. ncbi A diverse and evolutionarily fluid set of microRNAs in Arabidopsis thaliana
    Ramya Rajagopalan
    Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Genes Dev 20:3407-25. 2006
    ....
  30. ncbi The structure of alpha-thrombin inhibited by a 15-mer single-stranded DNA aptamer
    K Padmanabhan
    Department of Chemistry, Michigan State University, East Lansing 48824 1322
    J Biol Chem 268:17651-4. 1993
    ..Although G-quadruplexes are favored in the presence of monovalent cations, there is no evidence of the latter in the thrombin complex...
  31. ncbi The mitochondrial genome of the honeybee Apis mellifera: complete sequence and genome organization
    R H Crozier
    Department of Genetics and Human Variation, La Trobe University, Bundoora, Victoria, Australia
    Genetics 133:97-117. 1993
    ....
  32. ncbi The long and the short of riboswitches
    Alexander Serganov
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Curr Opin Struct Biol 19:251-9. 2009
    ....
  33. ncbi Folding DNA to create nanoscale shapes and patterns
    Paul W K Rothemund
    Departments of Computer Science and Computation and Neural Systems, California Institute of Technology, Pasadena, California 91125, USA
    Nature 440:297-302. 2006
    ..Finally, individual DNA structures can be programmed to form larger assemblies, including extended periodic lattices and a hexamer of triangles (which constitutes a 30-megadalton molecular complex)...
  34. ncbi Design of simple synthetic RNA thermometers for temperature-controlled gene expression in Escherichia coli
    Juliane Neupert
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, D 14476 Potsdam Golm, Germany
    Nucleic Acids Res 36:e124. 2008
    ..Our data suggest that the thermometers function by a simple melting mechanism and thus provide minimum size on/off switches to experimentally induce or repress gene expression by temperature...
  35. ncbi Origins of specificity in protein-DNA recognition
    Remo Rohs
    Howard Hughes Medical Institute, Center for Computational Biology and Bioinformatics, Columbia University, New York, NY 10032, USA
    Annu Rev Biochem 79:233-69. 2010
    ....
  36. ncbi Computational approaches to 3D modeling of RNA
    Christian Laing
    Department of Chemistry and Courant Institute of Mathematical Sciences, New York University, 251 Mercer Street, New York, NY 10012, USA
    J Phys Condens Matter 22:283101. 2010
    ..We conclude by outlining some suggestions for future RNA folding research...
  37. ncbi Cracking pre-40S ribosomal subunit structure by systematic analyses of RNA-protein cross-linking
    Sander Granneman
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, Scotland, UK
    EMBO J 29:2026-36. 2010
    ..Nob1 binds before pre-rRNA cleavage, and we conclude that structural reorganization is needed to bring together the catalytic PIN domain and its target...
  38. ncbi Folding of a transcriptionally acting preQ1 riboswitch
    Ulrike Rieder
    Institute of Organic Chemistry and Center for Molecular Biosciences, University of Innsbruck, Innrain 52a, 6020 Innsbruck, Austria
    Proc Natl Acad Sci U S A 107:10804-9. 2010
    ..A model is presented how a riboswitch that provides no obvious overlap between aptamer and terminator stem-loop solves this communication problem by involving bistable sequence determinants...
  39. ncbi CENTROIDFOLD: a web server for RNA secondary structure prediction
    Kengo Sato
    Japan Biological Informatics Consortium, 2 45 Aomi, Koto ku, Tokyo 135 8073, Japan
    Nucleic Acids Res 37:W277-80. 2009
    ..The major advantage of this server is that it employs our original CentroidFold software as its prediction engine which scores the best accuracy in our benchmark results. Our web server is freely available with no login requirement...
  40. ncbi Sliced microRNA targets and precise loop-first processing of MIR319 hairpins revealed by analysis of the Physcomitrella patens degradome
    Charles Addo-Quaye
    Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    RNA 15:2112-21. 2009
    ..MIR319 is thus a conserved exception to the general rule of loop-last processing of MIRNA hairpins. Loop-first MIR319 processing may contribute to the high efficacy of a widely used MIR319-based strategy for aMIRNA production in plants...
  41. ncbi Bridging IRES elements in mRNAs to the eukaryotic translation apparatus
    Kerry D Fitzgerald
    Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, CA 92697, USA
    Biochim Biophys Acta 1789:518-28. 2009
    ....
  42. ncbi NNDB: the nearest neighbor parameter database for predicting stability of nucleic acid secondary structure
    Douglas H Turner
    Department of Chemistry and Center for RNA Biology, Box 0216, University of Rochester, Rochester, NY 14627 0216, USA
    Nucleic Acids Res 38:D280-2. 2010
    ..The initial release covers parameters for predicting RNA folding free energy and enthalpy changes...
  43. ncbi A new type of IRES within gag coding region recruits three initiation complexes on HIV-2 genomic RNA
    Laure Weill
    CNRS UMR 8015, Laboratoire de cristallographie et RMN Biologique, Universite Paris Descartes, 4 avenue de l Observatoire, 75270 Paris Cedex 06, France
    Nucleic Acids Res 38:1367-81. 2010
    ..The structural and functional properties of gag coding sequence define a new type of IRES. Although its precise role is unknown, the conservation of the IRES among fast evolving lentiviruses suggests an important physiological role...
  44. ncbi 2-D structure of the A region of Xist RNA and its implication for PRC2 association
    Sylvain Maenner
    Faculte des Sciences et Techniques, AREMS, Nancy Universite, UMR 7214 CNRS UHP 1, Vandoeuvre les Nancy, France
    PLoS Biol 8:e1000276. 2010
    ..Our data with their emphasis on the importance of inter-repeat pairing change fundamentally our conception of the 2-D structure of the A region of Xist RNA and support its possible implication in recruitment of the PRC2 complex...
  45. ncbi Idiosyncratically tuned switching behavior of riboswitch aptamer domains revealed by comparative small-angle X-ray scattering analysis
    Nathan J Baird
    Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    RNA 16:598-609. 2010
    ..It is possible that the range of behaviors observed by SAXS, rather than being a biophysical idiosyncrasy, reflects adaptation of riboswitches to the regulatory requirements of their individual genomic context...
  46. ncbi Atomic accuracy in predicting and designing noncanonical RNA structure
    Rhiju Das
    Departments of Biochemistry and Physics, Stanford University, Stanford, California, USA
    Nat Methods 7:291-4. 2010
    ..Sequence redesign calculations recovered native bases at 65% of residues engaged in noncanonical interactions, and we experimentally validated mutations predicted to stabilize a signal recognition particle domain...
  47. ncbi Analysis of four-way junctions in RNA structures
    Christian Laing
    Department of Chemistry and Courant Institute of Mathematical Sciences, New York University, New York, 10012, USA
    J Mol Biol 390:547-59. 2009
    ..Such analyses of RNA building blocks can ultimately help in the difficult task of RNA 3D structure prediction...
  48. ncbi First snapshots of the HIV-1 RNA structure in infected cells and in virions
    Jean Christophe Paillart
    Unité Propre de Recherche 9002 du CNRS conventionnée à l Université Louis Pasteur, Institut de Biologie Moleculaire et Cellulaire, 15 rue Rene Descartes, 67084 Strasbourg Cedex, France
    J Biol Chem 279:48397-403. 2004
    ..Taken together, our results provided the first analysis of the dynamic of RNA structure of the human immunodeficiency virus type 1 RNA genome during virus assembly ex vivo...
  49. ncbi The Strepsiptera problem: phylogeny of the holometabolous insect orders inferred from 18S and 28S ribosomal DNA sequences and morphology
    M F Whiting
    Department of Zoology and M L Bean Life Science Museum, Brigham Young University, Provo, Utah 84602, USA
    Syst Biol 46:1-68. 1997
    ....
  50. ncbi Coding-sequence determinants of gene expression in Escherichia coli
    Grzegorz Kudla
    Department of Biology and Program in Applied Mathematics and Computational Science, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 324:255-8. 2009
    ..In our analysis, mRNA folding and associated rates of translation initiation play a predominant role in shaping expression levels of individual genes, whereas codon bias influences global translation efficiency and cellular fitness...
  51. ncbi RNA structure of trinucleotide repeats associated with human neurological diseases
    Krzysztof Sobczak
    Laboratory of Cancer Genetics, Institute of Bioorganic Chemistry, Polish Academy of Science, Noskowskiego 12/14, 61-704 Poznan, Poland
    Nucleic Acids Res 31:5469-82. 2003
    ..We have provided experimental evidence that CCUG repeats implicated in myotonic dystrophy type 2 also form hairpin structures with properties similar to that composed of the CUG repeats...
  52. ncbi Selective stabilization of mammalian microRNAs by 3' adenylation mediated by the cytoplasmic poly(A) polymerase GLD-2
    Takayuki Katoh
    Department of Chemistry and Biotechnology, Graduate School of Engineering, University of Tokyo, Bunkyo ku, Tokyo 113 8656, Japan
    Genes Dev 23:433-8. 2009
    ....
  53. ncbi Conformational analysis of nucleic acids revisited: Curves+
    R Lavery
    Institut de Biologie et Chimie des Proteines, CNRS UMR 5086 Universite de Lyon, 7 passage du Vercors, 69367 Lyon, France
    Nucleic Acids Res 37:5917-29. 2009
    ..With the help of the accompanying program Canal, it is possible to produce a variety of graphical output including parameter variations along a given structure and time series or histograms of parameter variations during dynamics...
  54. ncbi mRNA secondary structures fold sequentially but exchange rapidly in vivo
    Elisabeth M Mahen
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, USA
    PLoS Biol 8:e1000307. 2010
    ....
  55. ncbi Using DNA mechanics to predict in vitro nucleosome positions and formation energies
    Alexandre V Morozov
    Department of Physics and Astronomy and BioMaPS Institute for Quantitative Biology, Rutgers University, 136 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Nucleic Acids Res 37:4707-22. 2009
    ..We find that DNABEND can successfully predict in vitro nucleosome positions and free energies, providing a physical explanation for the intrinsic sequence dependence of histone-DNA interactions...
  56. ncbi Comparative genomics reveals 104 candidate structured RNAs from bacteria, archaea, and their metagenomes
    Zasha Weinberg
    Howard Hughes Medical Institute, Yale University, New Haven, CT 06520 8103, USA
    Genome Biol 11:R31. 2010
    ..Structured RNAs can be detected by comparative genomics, in which homologous sequences are identified and inspected for mutations that conserve RNA secondary structure...
  57. ncbi Identification of protein binding sites on U3 snoRNA and pre-rRNA by UV cross-linking and high-throughput analysis of cDNAs
    Sander Granneman
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Michael Swann Building, Kings Buildings, Mayfield Road, Edinburgh EH9 3JR, Scotland
    Proc Natl Acad Sci U S A 106:9613-8. 2009
    ..This finding demonstrates that the snoRNP proteins directly contact the pre-rRNA substrate, suggesting roles in snoRNA recruitment. The techniques reported here should be widely applicable to analyses of RNA-protein interactions...
  58. ncbi Programmed ribosomal frameshifting in HIV-1 and the SARS-CoV
    Ian Brierley
    Division of Virology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Virus Res 119:29-42. 2006
    ..The role of frameshifting in the replication cycle of the two pathogens and potential antiviral therapies targeting frameshifting will also be discussed...
  59. ncbi Fast and effective prediction of microRNA/target duplexes
    Marc Rehmsmeier
    Universitat Bielefeld, International NRW Graduate School in Bioinformatics and Genome Research, Postfach 10 01 31, 33501 Bielefeld, Germany
    RNA 10:1507-17. 2004
    ..RNAhybrid, with its accompanying programs RNAcalibrate and RNAeffective, is available for download and as a Web tool on the Bielefeld Bioinformatics Server (http://bibiserv.techfak.uni-bielefeld.de/rnahybrid/)...
  60. ncbi Structural basis for the suppression of skin cancers by DNA polymerase eta
    Timothy D Silverstein
    Department of Structural and Chemical Biology, Mount Sinai School of Medicine, Box 1677, 1425 Madison Avenue, New York, New York 10029, USA
    Nature 465:1039-43. 2010
    ....
  61. ncbi Computational approaches for RNA energy parameter estimation
    Mirela Andronescu
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
    RNA 16:2304-18. 2010
    ..Our data, software, results, and parameter sets in various formats are freely available at http://www.cs.ubc.ca/labs/beta/Projects/RNA-Params...
  62. ncbi CAG repeats containing CAA interruptions form branched hairpin structures in spinocerebellar ataxia type 2 transcripts
    Krzysztof Sobczak
    Laboratory of Cancer Genetics, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12 14, 61 704 Poznan, Poland
    J Biol Chem 280:3898-910. 2005
    ..The structural organization of the repeat interruption systems present in other human transcripts, such as SCA1, TBP, FOXP2, and MAML2, are also discussed...
  63. ncbi Dynamics of DNA breathing: weak noise analysis, finite time singularity, and mapping onto the quantum Coulomb problem
    Hans C Fogedby
    Department of Physics and Astronomy, University of Aarhus, Ny Munkegade, Aarhus C, Denmark
    Phys Rev E Stat Nonlin Soft Matter Phys 76:061915. 2007
    ..Correlations and finite size effects are discussed...
  64. ncbi Indirect recognition in sequence-specific DNA binding by Escherichia coli integration host factor: the role of DNA deformation energy
    Kimberly A Aeling
    Institute for Genomics and Bioinformatics, Department of Microbiology and Molecular Genetics, School of Medicine, University of California 92697, USA
    J Biol Chem 281:39236-48. 2006
    ....
  65. ncbi Programmable oligomers targeting 5'-GGGG-3' in the minor groove of DNA and NF-kappaB binding inhibition
    David M Chenoweth
    The Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA
    Bioorg Med Chem 15:759-70. 2007
    ..Five Bi and Ip containing oligomers bound to the 5'-WGGGGW-3' site with high affinity. One of the oligomers (Im-Im-Im-Im-gamma-Py-Bi-Py-Bi-beta-Dp) was able to inhibit DNA binding by the transcription factor NF-kappaB...
  66. ncbi Demonstration that the shear force required to separate short double-stranded DNA does not increase significantly with sequence length for sequences longer than 25 base pairs
    K Hatch
    Physics Department, Harvard University, Cambridge, MA 02138, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 78:011920. 2008
    ..The single base pair rupture force and the ratio of the backbone spring constant to the base pair spring constant determined from fits of the data to deGennes' theory are consistent with ab initio predictions...
  67. ncbi Distinguishing L from M photopigment coding sequences by hybridization to novel locked nucleic acid (LNA) oligonucleotide probes
    Christina Pettan-Brewer
    Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    Vis Neurosci 25:283-7. 2008
    ..This result strongly suggests that these probes would be instrumental in rapidly distinguishing L from M cone in the entire retina, and in defining the cone mosaic during development and in adults...
  68. ncbi DNA bending induced by carbocyclic sugar analogs constrained to the north conformation
    Alba T Macias
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
    Biopolymers 85:438-49. 2007
    ....
  69. ncbi Control of macromolecular structure and function using covalently attached double-stranded DNA constraints
    Scott K Silverman
    Department of Chemistry, University of Illinois at Urbana Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, USA
    Mol Biosyst 3:24-9. 2007
    ..If practical challenges such as delivery and stability can be addressed, these new efforts may also enable development of selective sensors for in vivo applications...
  70. ncbi A simple molecular model for thermophilic adaptation of functional nucleic acids
    Joshua M Blose
    Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Biochemistry 46:4232-40. 2007
    ..The ability to increase the melting temperature of tertiary structure by strengthening base-pairing interactions separate from tertiary interactions provides a simple means for evolving thermostability in functional RNAs...
  71. ncbi Allosteric control of ribozyme catalysis by using DNA constraints
    Elena Zelin
    Department of Chemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, IL 61801, USA
    Chembiochem 8:1907-11. 2007
  72. ncbi "Parallel" and "antiparallel tail-clamps" increase the efficiency of triplex formation with structured DNA and RNA targets
    Anna Nadal
    , Institut de Biologia Molecular de Barcelona, , Jordi Girona 18-26, 08034 Barcelona, Spain
    Chembiochem 6:1034-42. 2005
    ..In addition, the reported triplex-stabilizing property of 8-aminopurine residues was confirmed for tail-clamps. Finally, we discuss the possible use of this improved triplex technology as a new tool for applications in molecular biology...
  73. ncbi Structural and thermodynamic basis for enhanced DNA binding by a promiscuous mutant EcoRI endonuclease
    Paul J Sapienza
    Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Structure 15:1368-82. 2007
    ..The interactions of Thr138 with flanking bases may permit A138T, unlike wild-type enzyme, to form complexes with EcoRI(*) sites that structurally resemble the specific wild-type complex with GAATTC...
  74. ncbi The MC-Fold and MC-Sym pipeline infers RNA structure from sequence data
    Marc Parisien
    Institute for Research in Immunology and Cancer, Department of Computer Science and Operations Research, Universite de Montreal, PO Box 6128, Downtown Station, Montreal, Quebec H3C 3J7, Canada
    Nature 452:51-5. 2008
    ....
  75. ncbi Effect of DNA modifications on DNA processing by HIV-1 integrase and inhibitor binding: role of DNA backbone flexibility and an open catalytic site
    Allison A Johnson
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health/DHHS, Bethesda, MD 20892, USA
    J Biol Chem 281:32428-38. 2006
    ..Together, these results demonstrate the importance of DNA structure and specific contacts with the viral DNA processing site for inhibition by integrase inhibitors...
  76. ncbi Roles of RNA:DNA hybrid stability, RNA structure, and active site conformation in pausing by human RNA polymerase II
    M Palangat
    Department of Bacteriology, University of Wisconsin-Madison, 1550 Linden Dr, Madison, WI 53706, USA
    J Mol Biol 311:265-82. 2001
    ....
  77. ncbi The intercalating beta-hairpin of T7 RNA polymerase plays a role in promoter DNA melting and in stabilizing the melted DNA for efficient RNA synthesis
    Natalie M Stano
    Department of Biochemistry, Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
    J Mol Biol 315:1009-25. 2002
    ..The interactions of E242 and D240 with the upstream junction of the melted dsDNA promoter also align the template strand within the active site for efficient RNA synthesis...
  78. ncbi Structural and functional properties of the HIV-1 RNA-tRNA(Lys)3 primer complex annealed by the nucleocapsid protein: comparison with the heat-annealed complex
    Fabienne Brule
    Unite Propre de Recherche 9002, Centre Nationale de la Recherche Scientifique, Institut de Biologie Moleculaire et Cellulaire, Strasbourg, France
    RNA 8:8-15. 2002
    ..We did not find any significant differences between these complexes, suggesting that information derived from the heat-annealed complex can be transposed to the NCp-mediated complex and most likely to complexes formed in vivo...
  79. ncbi A viral RNA that binds ATP and contains a motif similar to an ATP-binding aptamer from SELEX
    Dan Shu
    Department of Pathobiology and Purdue Cancer Center, Purdue University, West Lafayette, Indiana 47907, USA
    J Biol Chem 278:7119-25. 2003
    ..This is the first demonstration of a natural RNA molecule that binds ATP and the first case to report the presence of a SELEX-derived RNA aptamer in living organisms...
  80. ncbi Guanine of the third strand of C.G*G triplex serves as an effective hole trap
    Chikara Dohno
    Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University, CREST, Japan Science and Technology Corporation (JST, Kyoto 606-8501, Japan
    J Am Chem Soc 124:14580-5. 2002
    ..These results indicate that the oxidative damage preferentially occurred at Gs of the third strand owing to thermodynamic and kinetic features of the one-electron oxidation of the C.GG triplex...
  81. ncbi Protein-facilitated base flipping in DNA by cytosine-5-methyltransferase
    Niu Huang
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 100:68-73. 2003
    ..This study represents an atomic detail description of the mechanism by which a protein facilitates specific structural distortion in DNA...
  82. ncbi Molecular design of a pyrrole-imidazole hairpin polyamides for effective DNA alkylation
    Toshikazu Bando
    Division of Biofunctional Molecules, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Surugadai, Kanda, Chiyoda, Tokyo 101-0062, Japan
    Chemistry 8:4781-90. 2002
    ..These results demonstrate that incorporation of the vinyl-linker pairing with Im dramatically improves the reactivity of hairpin polyamide--CPI conjugates...
  83. ncbi Sequence-selective targeting of long stretches of the DNA minor groove by a novel dimeric bis-benzimidazole
    Alexandra Joubert
    INSERM U-524 et Laboratoire de Pharmacologie Antitumorale du Centre Oscar Lambret, IRCL, Place de Verdun, 59045 Lille, France
    Biochemistry 42:5984-92. 2003
    ..Compound 5 does not show acute cellular cytotoxicity, in contrast with its monomeric bis-benzimidazole precursors, yet is rapidly taken up into cells...
  84. ncbi A novel, modification-dependent ATP-binding aptamer selected from an RNA library incorporating a cationic functionality
    Narendra K Vaish
    Department of Chemistry, Boston College, 140 Commonwealth Avenue, Chestnut Hill, Massachusetts 02467, USA
    Biochemistry 42:8842-51. 2003
    ..In addition, new materials generated from such functionalized nucleic acids could be useful tools in research and diagnostics...
  85. ncbi Targeting degradation of RNA by RNase H using DNA hairpins
    Jing Li
    School of Biology, Georgia Institute of Technology, Atlanta, Georgia 30332-0230, USA
    Biochemistry 42:10945-54. 2003
    ..The in vitro results indicate that DNA hairpins can enhance the stringency of RNase H targeted degradation of the RNA sites...
  86. ncbi Dynamic NMR structures of [Rp]- and [Sp]-phosphorothioated DNA-RNA hybrids: is flexibility required for RNase H recognition?
    Marco Tonelli
    Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California 94143 2280 USA
    Biophys J 85:2525-38. 2003
    ..These observations, together with the analysis of the crystal structure of a hybrid duplex in complex with ribonuclease H (RNase H), suggested that this flexibility may be required for recognition by RNase H...
  87. ncbi NMR spectroscopy of RNA
    Boris Fürtig
    Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance, Johann Wolfgang Goethe University, Marie Curie Strasse 11, 60439 Frankfurt am Main, Germany
    Chembiochem 4:936-62. 2003
    ....
  88. ncbi Automated selection of anti-protein aptamers
    J C Cox
    Institute for Cellular and Molecular Biology, University of Texas at Austin, 78712, USA
    Bioorg Med Chem 9:2525-31. 2001
    ..The increases in throughput brought about by automation should potentiate the application of aptamer technology to the rapidly growing field of proteomics...
  89. ncbi Productive folding to the native state by a group II intron ribozyme
    Jennifer F Swisher
    Integrated Program in Cellular, Molecular, and Biophysical Studies, Columbia University, New York, NY 10032, USA
    J Mol Biol 315:297-310. 2002
    ..We propose that this behavior resembles protein folding that is limited in rate by high contact order, or the need to form key tertiary interactions from partners that are located far apart in the primary or secondary structure...
  90. ncbi Indirect readout of DNA sequence at the primary-kink site in the CAP-DNA complex: DNA binding specificity based on energetics of DNA kinking
    S Chen
    Department of Chemistry and The Waksman Institute, Rutgers, The State University of New Jersey, 610 Taylor Road, Piscataway, NJ 08854 8087, USA
    J Mol Biol 314:63-74. 2001
    ..We further infer that the main determinant of DNA conformation in this system is protein-DNA interaction, and not DNA sequence...
  91. ncbi A pH controlled conformational switch in the cleavage site of the VS ribozyme substrate RNA
    J Flinders
    Department of Chemistry, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA
    J Mol Biol 308:665-79. 2001
    ..C pair with a protonated adenine. This adenine (A622) is a pH controlled conformational switch that opens up the internal loop at higher pH. The possible significance of this switch for substrate recognition and cleavage is discussed...
  92. ncbi The RNA i-motif
    K Snoussi
    Groupe de Biophysique de l' Ecole Polytechnique et de l'UMR 7643 du CNRS, Palasieau, France
    J Mol Biol 309:139-53. 2001
    ..The free energy of the RNA i-motif, on average -4 kJ mol(-1) per C.C+ pair, is half of the value found in DNA i-motif structures...
  93. ncbi Electrostatic control of half-site spacing preferences by the cyclic AMP response element-binding protein CREB
    J K Montclare
    Department of Chemistry, Yale University, PO Box 208107, New Haven, CT 06520-8107, USA
    Nucleic Acids Res 29:3311-9. 2001
    ..The finding that the CRE/AP-1 specificity of CREB is dictated by the presence or absence of charged residues has interesting implications for how transcription factors seek and selectively bind sequences within genomic DNA...
  94. ncbi N(omega)-arginine dimethylation modulates the interaction between a Gly/Arg-rich peptide from human nucleolin and nucleic acids
    B Raman
    International Centre for Genetic Engineering and Biotechnology, Padriciano 99, 34012 Trieste, Italy
    Nucleic Acids Res 29:3377-84. 2001
    ..However, circular dichroism studies show that unmethylated peptide can perturb the helical structure, especially in RNA, to a much larger extent than the DMA peptide...
  95. ncbi The structural basis of ribosome activity in peptide bond synthesis
    P Nissen
    Department of Molecular Biophysics and Biochemistry and Department of Chemistry, Yale University, and Howard Hughes Medical Institute, New Haven, CT 06520-8114, USA
    Science 289:920-30. 2000
    ..The polypeptide exit tunnel is largely formed by RNA but has significant contributions from proteins L4, L22, and L39e, and its exit is encircled by proteins L19, L22, L23, L24, L29, and L31e...
  96. ncbi Methyl groups of thymine bases are important for nucleic acid recognition by DtxR
    C S Chen
    Department of Biochemistry, Program in Bioorganic Chemistry, The Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, Massachusetts 02454 9110, USA
    Biochemistry 39:10397-407. 2000
    ....
  97. ncbi Thermodynamics of HMGB1 interaction with duplex DNA
    S Muller
    DIBIT, San Raffaele Scientific Institute, Via Olgettina 58, 2032 Milano, Italy
    Biochemistry 40:10254-61. 2001
    ..dTdA) was cooperative, had a larger apparent binding site size, and proceeded with a much larger unfavorable binding enthalpy than binding to poly(dGdC).(dCdG)...
  98. ncbi Attenuation of gene expression by a trinucleotide repeat-rich tract from the terminal exon of the rat hepatic polymeric immunoglobulin receptor gene
    T Aoki
    Department of Biochemistry, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari Tobetsu, Japan
    J Mol Biol 267:229-36. 1997
    ....
  99. ncbi The molecular basis of the undulated/Pax-1 mutation
    G Chalepakis
    Max Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Gottingen, Federal Republic of Germany
    Cell 66:873-84. 1991
    ..These results decipher the molecular basis of the un mutation...
  100. ncbi Alterations in mRNA translation as a mechanism for the modification of enzyme synthesis during evolution. The ornithine decarboxylase model
    G Johannes
    Department of Biological Sciences, University of South Carolina, Columbia 29208
    J Biol Chem 267:10108-15. 1992
    ..We conclude that during evolution, modifications that alter the biosynthesis of specific proteins can occur at the translational level; these modifications exert their effects on translation in a transcript- and tissue-specific manner...
  101. ncbi Molecular dynamics simulations of B '-DNA: sequence effects on A-tract-induced bending and flexibility
    K J McConnell
    Chemistry Department and Molecular Biophysics Program, Wesleyan University, Middletown, CT 06459, USA
    J Mol Biol 314:23-40. 2001
    ..The MD results are found to be consistent with the directionality of bending inferred for DNA sequences from gel retardation and cyclization experiments...

Research Grants102 found, 100 shown here

  1. STRUCTURE OF VIRAL RNA AND ITS ROLE IN ASSEMBLY
    Alexander McPherson; Fiscal Year: 2006
    ..To extend our investigations of nucleic acid conformation and packaging to larger, more complex viruses we will extend our AFM investigations of the internal ..
  2. X RAY STUDIES OF NUCLEIC ACID CONSTITUENTS
    Muttaiya Sundaralingam; Fiscal Year: 2001
    ..The work will provide the limits of nucleic acid conformation, details of the tertiary structures of the duplexes, novel base-pairing schemes, base triples and ..
  3. BIOCHEMICAL MECHANISM OF EXOCYCLIC ADDUCTS IN CANCER
    Bo Hang; Fiscal Year: 2004
    ..These adducts, when incorporated into DNA, will be studied in terms of resulting changes in nucleic acid conformation using thermodynamics, molecular modeling and NMR...
  4. DNA/RNA Quadruplexes: Structure, Stability, Interactions
    RICHARD SHAFER; Fiscal Year: 2006
    This project focuses on the unusual nucleic acid conformation of quadruplexes, built upon the guanine quartet...
  5. NUCLEIC ACID CONFORMATION, PROPERTIES, AND INTERACTIONS
    WILMA OLSON; Fiscal Year: 1980
    ..energy calculations and statistical mechanical analyses it is possible both to elucidate details of nucleic acid conformation and also to provide a rational understanding of observed experimental phenomena...
  6. Acquisition of a Circular Dichroism Spectrometer
    Barbara Brodsky; Fiscal Year: 2002
    ..The present CD instrument (an Aviv 62 DS provided a cutting edge research tool for studying protein and nucleic acid conformation, stability, and ligand binding to the laboratories of 5 NIH-funded major users, and more than 20 funded ..
  7. NUCLEIC ACID CONFORMATION, PROPERTIES, AND INTERACTIONS
    WILMA OLSON; Fiscal Year: 2006
    ..New approaches to build atomic models of DNA that take explicit account of the closely associated cloud of bound waters are also under development. ..
  8. NUCLEIC ACID CONFORMATION, PROPERTIES, AND INTERACTIONS
    WILMA OLSON; Fiscal Year: 2001
    ....
  9. Nanomedicine Center for Protein Deposition Diseases(RMI)
    Yuri Lyubchenko; Fiscal Year: 2004
    ..We assembled a multidisciplinary team of 12 investigators with broad expertise in nanobiology, imaging, spectroscopy, single molecule biophysics, proteomics, drug delivery and medicine. ..
  10. CONFORMATIONAL PROPERTIES OF DNA CATENANES
    Alexander Vologodskii; Fiscal Year: 2006
    ..New computational methods will be developed in the project which will allow us to estimate probabilities of very rare events, related to juxtaposition of specific DNA sites. ..
  11. Bioscope II - AFM system for Nanoimaging Core Facility
    Yuri Lyubchenko; Fiscal Year: 2007
    ..There are two NIH funded investigators outside the campus who also want to use the unique features of the integrated Bioscope/IX71 system. ..
  12. LOCAL AND GLOBAL CONFORMATIONS OF SUPERCOILED DNA
    Yuri Lyubchenko; Fiscal Year: 2007
    ..abstract_text> ..
  13. CONFORMATIONAL PROPERTIES OF DNA CATENANES
    Alexander Vologodskii; Fiscal Year: 2002
    ....
  14. LOCAL AND GLOBAL STRUCTURES OF SUPERCOILED DNA
    Yuri Lyubchenko; Fiscal Year: 2003
    ..The studies outlined above will utilize atomic force microscopy (AFM), 2-dimensional agarose gel electrophoresis, and chemical probe analysis for structural studies of DNA and nucleoprotein complexes. ..
  15. A hybrid 12T Q-FTMS for the investigation of nucleic acids non-cov./cov.adducts
    Daniele Fabris; Fiscal Year: 2006
    ....
  16. Protein-Facilitates RNA Catalysts
    KEVIN WEEKS; Fiscal Year: 2007
    ..5) To begin to explore the molecular mechanism by which Mrs1 facilitates catalysis of the bl3 group I intron. (6) To develop a high resolution model for the maturase-bl3 RNA complex. ..
  17. Biosynthetic Protein Models of Heme-copper Oxidases and Nitric Oxide Reductases
    Yi Lu; Fiscal Year: 2007
    ..The work will make important contributions to healthcare, as it will provide a molecular basis for understanding two enzymes important to human health. ..
  18. Development of siRNAs to Prevent and Treat Influenza Infection
    Qing Ge; Fiscal Year: 2006
    ....
  19. Regulation of Transcription at the Human IL-2 Promoter
    James Goodrich; Fiscal Year: 2006
    ..abstract_text> ..
  20. The Mammalian Signal Recognition Particle
    KEVIN WEEKS; Fiscal Year: 2006
    ..Moreover, the work is designed to identify principles generalizable to other biologically and medically prominent ribonucleoprotein complexes. ..
  21. CHARACTERIZATION & ORGANIZATION OF TRANSPOSABLE ELEMENTS
    Zhijian Tu; Fiscal Year: 2006
    ..Finally, this work will enhance our understanding of the basic genetics of An. gambiae by systematically investigating TEs, which are substantial and potentially potent components of the genome...