carbohydrate conformation

Summary

Summary: The characteristic 3-dimensional shape of a carbohydrate.

Top Publications

  1. ncbi Intramolecular carbohydrate-aromatic interactions and intermolecular van der Waals interactions enhance the molecular recognition ability of GM1 glycomimetics for cholera toxin
    Anna Bernardi
    Università di Milano Dipartimento di Chimica Organica e Industriale e Centro di Eccellenza CISI via Venezian 21, 20133 Milano, Italy
    Chemistry 10:4395. 2004
  2. ncbi Intracellular functions of N-linked glycans
    A Helenius
    Institute of Biochemistry, , , , Switzerland
    Science 291:2364-9. 2001
  3. ncbi CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides
    T Kawano
    CREST Core Research for Evolutional Science and Technology Project, Japan Science and Technology Corporation JST, 1 8 1 Inohana, Chuo, Chiba 260, Japan
    Science 278:1626-9. 1997
  4. pmc High-mannose glycans are elevated during breast cancer progression
    Maria Lorna A de Leoz
    Department of Chemistry, University of California Davis, Davis, CA 95616, USA
    Mol Cell Proteomics 10:M110.002717. 2011
  5. doi Isomeric analysis of oligomannosidic N-glycans and their dolichol-linked precursors
    Martin Pabst
    Department of Chemistry, University of Natural Resources and Life Sciences, Muthgasse 18, 1190 Vienna, Austria
    Glycobiology 22:389-99. 2012
  6. ncbi Structural characterization of N-linked oligosaccharides on monoclonal antibody cetuximab by the combination of orthogonal matrix-assisted laser desorption/ionization hybrid quadrupole-quadrupole time-of-flight tandem mass spectrometry and sequential enzy
    Jun Qian
    Department of Bioanalytical Science, ImClone Systems Incorporated, Branchburg, NJ 08876, USA
    Anal Biochem 364:8-18. 2007
  7. pmc Anticoagulant heparan sulfate: structural specificity and biosynthesis
    Jian Liu
    Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina, Rm 309, Beard Hall, Chapel Hill, NC 27599, USA
    Appl Microbiol Biotechnol 74:263-72. 2007
  8. doi The repertoire of glycan determinants in the human glycome
    Richard D Cummings
    Department of Biochemistry, Emory University School of Medicine, 1510 Clifton Rd 4001, Atlanta, GA 30322, USA
    Mol Biosyst 5:1087-104. 2009
  9. pmc Carbohydrate Structure Suite (CSS): analysis of carbohydrate 3D structures derived from the PDB
    Thomas Lütteke
    Central Spectroscopic Department, German Cancer Research Centre, INF 280, D 69120 Heidelberg, Germany
    Nucleic Acids Res 33:D242-6. 2005
  10. ncbi Electrospray ionization mass spectrometry of oligosaccharides derived from fucoidan of Ascophyllum nodosum
    Regis Daniel
    CNRS, UMR 8587, Laboratoire Analyse et Modelisation pour la Biologie et l Environnement, Universite d Evry Val d Essonne, F 91025 Evry, France
    Carbohydr Res 342:826-34. 2007

Research Grants

  1. A Thermo Electron LTQ Mass Spectrometer
    Joseph Zaia; Fiscal Year: 2006
  2. Glycosaminoglycan-Protein Binding
    Joseph Zaia; Fiscal Year: 2006
  3. Host Response in S. aureus Infections: Role of T cells
    Arthur Tzianabos; Fiscal Year: 2006
  4. TOTAL SYNTHESIS OF AZASPIRACIDS
    K Nicolaou; Fiscal Year: 2006
  5. TOTAL SYNTHESIS OF NATURAL PRODUCTS
    K Nicolaou; Fiscal Year: 2002
  6. Enabling Technologies for Combinatorial Chemistry
    K Nicolaou; Fiscal Year: 2005
  7. Chemical Synthesis of Beta Manno-and Rhamnopyranosides
    David Crich; Fiscal Year: 2005
  8. FASEB Summer Conference on Microbial Polysaccharides
    Arthur Tzianabos; Fiscal Year: 2004
  9. TOTAL SYNTHESIS OF APOPTOLIDIN
    K Nicolaou; Fiscal Year: 2004
  10. Methods and Mechanisms in Carbohydrate Chemistry
    David Crich; Fiscal Year: 2003

Detail Information

Publications251 found, 100 shown here

  1. ncbi Intramolecular carbohydrate-aromatic interactions and intermolecular van der Waals interactions enhance the molecular recognition ability of GM1 glycomimetics for cholera toxin
    Anna Bernardi
    Università di Milano Dipartimento di Chimica Organica e Industriale e Centro di Eccellenza CISI via Venezian 21, 20133 Milano, Italy
    Chemistry 10:4395. 2004
    ..The exploitation of this kind of sugar-aromatic interaction, which is very well described in the context of carbohydrate/protein complexes, may open new avenues for the rational design of sugar mimics...
  2. ncbi Intracellular functions of N-linked glycans
    A Helenius
    Institute of Biochemistry, , , , Switzerland
    Science 291:2364-9. 2001
    ..The division of synthesis and processing between the ER and the Golgi complex represents an evolutionary adaptation that allows efficient exploitation of the potential of oligosaccharides...
  3. ncbi CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides
    T Kawano
    CREST Core Research for Evolutional Science and Technology Project, Japan Science and Technology Corporation JST, 1 8 1 Inohana, Chuo, Chiba 260, Japan
    Science 278:1626-9. 1997
    ..Thus, this lymphocyte shares distinct recognition systems with either T or NK cells...
  4. pmc High-mannose glycans are elevated during breast cancer progression
    Maria Lorna A de Leoz
    Department of Chemistry, University of California Davis, Davis, CA 95616, USA
    Mol Cell Proteomics 10:M110.002717. 2011
    ..630 in both mouse and human sera in the presence of breast cancer, suggesting an incompletion of the glycosylation process that normally trims back Man(9) to produce complex and hybrid type oligosaccharides...
  5. doi Isomeric analysis of oligomannosidic N-glycans and their dolichol-linked precursors
    Martin Pabst
    Department of Chemistry, University of Natural Resources and Life Sciences, Muthgasse 18, 1190 Vienna, Austria
    Glycobiology 22:389-99. 2012
    ..A tightly woven net of evidence supports these assignments. Noteworthy, this isomer assignment happens in the course of a comprehensive analysis of all types of a sample's N-glycans...
  6. ncbi Structural characterization of N-linked oligosaccharides on monoclonal antibody cetuximab by the combination of orthogonal matrix-assisted laser desorption/ionization hybrid quadrupole-quadrupole time-of-flight tandem mass spectrometry and sequential enzy
    Jun Qian
    Department of Bioanalytical Science, ImClone Systems Incorporated, Branchburg, NJ 08876, USA
    Anal Biochem 364:8-18. 2007
    ..This study represents a unique approach in that MS/MS data were used to identify and confirm the oligosaccharide structures of a protein...
  7. pmc Anticoagulant heparan sulfate: structural specificity and biosynthesis
    Jian Liu
    Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina, Rm 309, Beard Hall, Chapel Hill, NC 27599, USA
    Appl Microbiol Biotechnol 74:263-72. 2007
    ..These advancements provide the foundation for the development of polysaccharide-based therapeutic agents...
  8. doi The repertoire of glycan determinants in the human glycome
    Richard D Cummings
    Department of Biochemistry, Emory University School of Medicine, 1510 Clifton Rd 4001, Atlanta, GA 30322, USA
    Mol Biosyst 5:1087-104. 2009
    ..These numbers provide an achievable target for new chemical and/or enzymatic syntheses, and raise new challenges for defining the total glycome and the determinants recognized by GBPs...
  9. pmc Carbohydrate Structure Suite (CSS): analysis of carbohydrate 3D structures derived from the PDB
    Thomas Lütteke
    Central Spectroscopic Department, German Cancer Research Centre, INF 280, D 69120 Heidelberg, Germany
    Nucleic Acids Res 33:D242-6. 2005
    ..Furthermore, tools to crosslink the PDB and carbohydrate databases and to check the integrity of carbohydrate 3D structures are included. The service is available at (www.dkfz.de/spec/css/)...
  10. ncbi Electrospray ionization mass spectrometry of oligosaccharides derived from fucoidan of Ascophyllum nodosum
    Regis Daniel
    CNRS, UMR 8587, Laboratoire Analyse et Modelisation pour la Biologie et l Environnement, Universite d Evry Val d Essonne, F 91025 Evry, France
    Carbohydr Res 342:826-34. 2007
    ..This study demonstrates that highly sulfated oligosaccharides from fucoidan can be analyzed by ESIMS which gives additional information about the structure of this highly complex polysaccharide...
  11. doi Regulated glycosylation patterns of IgG during alloimmune responses against human platelet antigens
    Manfred Wuhrer
    Department of Parasitology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands m wuhrer
    J Proteome Res 8:450-6. 2009
    ..Moreover, experiments in animal models as well as in vitro immunological tests will be needed to unravel the mechanisms regulating IgG Fc glycosylation...
  12. pmc Analysis and validation of carbohydrate three-dimensional structures
    Thomas Lütteke
    Bijvoet Centre for Biomolecular Research, BOC2, Utrecht University, Utrecht, The Netherlands
    Acta Crystallogr D Biol Crystallogr 65:156-68. 2009
    ....
  13. doi Novel glycan biomarkers for the detection of lung cancer
    James N Arnold
    Department of Biochemistry, Oxford Glycobiology Institute, University of Oxford, South Parks Road, Oxford OX1 3QU, England
    J Proteome Res 10:1755-64. 2011
    ..The combination of all glyco-biomarkers had the highest sensitivity and specificity. This study identifies candidates for further study as potential biomarkers for the disease...
  14. pmc A 3D-structural model of unsulfated chondroitin from high-field NMR: 4-sulfation has little effect on backbone conformation
    Benedict M Sattelle
    Manchester Interdisciplinary Biocentre, 131 Princess Street, Manchester, M1 7DN, UK
    Carbohydr Res 345:291-302. 2010
    ..Our conclusions exemplify the value of the 3D-model presented here and progress our understanding of glycosaminoglycan molecular properties...
  15. ncbi The glycosylation of human serum IgD and IgE and the accessibility of identified oligomannose structures for interaction with mannan-binding lectin
    James N Arnold
    Medical Research Council MRC Immunochemistry Unit and Oxford Glycobiology Institute, University of Oxford, United Kingdom
    J Immunol 173:6831-40. 2004
    ..This is the first study of the glycosylation of human serum IgD and IgE from nonmyeloma proteins...
  16. doi Enthalpic nature of the CH/pi interaction involved in the recognition of carbohydrates by aromatic compounds, confirmed by a novel interplay of NMR, calorimetry, and theoretical calculations
    Karla Ramírez-Gualito
    Instituto de Quimica, Universidad Nacional Autonoma de Mexico, Apdo Postal 70213, 04510 Coyoacan, Circuito Exterior, Mexico D F, Mexico
    J Am Chem Soc 131:18129-38. 2009
    ..Therefore, methoxy and acetyl substituents have different effects on the protons of the pyranose ring...
  17. ncbi Involvement of water in carbohydrate-protein binding
    C Clarke
    Complex Carbohydrate Research Center, 220 Riverbend Road, Athens, GA 30602, USA
    J Am Chem Soc 123:12238-47. 2001
    ..It is proposed that an indirect interaction through a water molecule will provide a larger number of hydrogen bonds in the complex that have higher occupancies than in bulk solution, thereby stabilizing the complex...
  18. pmc Elucidation of O-glycosylation structures of the beta-amyloid precursor protein by liquid chromatography-mass spectrometry using electron transfer dissociation and collision induced dissociation
    Irina Perdivara
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    J Proteome Res 8:631-42. 2009
    ..Thus, the combination of the CID and ETD techniques in LC-MS is shown here, as a powerful tool for de novo identification of O-glycosylations at unknown modification sites in proteins...
  19. pmc Annotation and structural analysis of sialylated human milk oligosaccharides
    Shuai Wu
    Department of Chemistry, University of California, Davis, California 95616, USA
    J Proteome Res 10:856-68. 2011
    ..When combined with previously determined neutral components, a library with over 70 structures is obtained allowing high-throughput oligosaccharide structure identification...
  20. doi The plasma von Willebrand factor O-glycome comprises a surprising variety of structures including ABH antigens and disialosyl motifs
    K Canis
    Division of Molecular Biosciences, Faculty of Natural Sciences, Imperial College, London, UK
    J Thromb Haemost 8:137-45. 2010
    ..So far only a single glycan structure, a disialyl core 1 glycan, has been identified...
  21. doi Less is more when simulating unsulfated glycosaminoglycan 3D-structure: comparison of GLYCAM06/TIP3P, PM3-CARB1/TIP3P, and SCC-DFTB-D/TIP3P predictions with experiment
    Benedict M Sattelle
    Faculty of Life Sciences, University of Manchester, 131 Princess Street, Manchester M1 7DN, United Kingdom
    J Comput Chem 31:2932-47. 2010
    ..Our data contribute to the debate and emerging consensus on the relative performance of these levels of theory for biological molecules...
  22. pmc Neuroactive chondroitin sulfate glycomimetics
    Manish Rawat
    Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA
    J Am Chem Soc 130:2959-61. 2008
  23. pmc Involvement of water in carbohydrate-protein binding: concanavalin A revisited
    Renuka Kadirvelraj
    Complex Carbohydrate Research Center, University of Georgia, 315 Riverbend Road, Athens, Georgia 30602, USA
    J Am Chem Soc 130:16933-42. 2008
    ....
  24. ncbi Molecular basis of C(2+)-induced gelation in alginates and pectins: the egg-box model revisited
    I Braccini
    , , CNRS, BP 53 X, 38041 Grenoble Cedex, France
    Biomacromolecules 2:1089-96. 2001
    ....
  25. ncbi Optimization of virulence functions through glucosylation of Shigella LPS
    Nicholas P West
    Centre for Molecular Microbiology and Infection, Department of Infectious Diseases, Faculty of Medicine, Flowers Building, Imperial College London, London SW7 2AZ, UK
    Science 307:1313-7. 2005
    ..Thus, LPS glucosylation promotes bacterial invasion and evasion of innate immunity, which may have contributed to the emergence of serotype diversity in Shigella...
  26. pmc Biosynthesis of truncated N-linked oligosaccharides results from non-orthologous hexosaminidase-mediated mechanisms in nematodes, plants, and insects
    Martin Gutternigg
    Department für Chemie, Universität für Bodenkultur, Muthgasse 18, Wien A 1190, Austria
    J Biol Chem 282:27825-40. 2007
    ..Based on these data, it is hypothesized that the genetic origin of paucimannosidic glycans in nematodes, plants, and insects involves highly divergent members of the same hexosaminidase gene family...
  27. pmc GlycoMapsDB: a database of the accessible conformational space of glycosidic linkages
    M Frank
    German Cancer Research Center, Spectroscopic Department B090 Molecular Modeling Group, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Nucleic Acids Res 35:287-90. 2007
    ..The service is available at www.glycosciences.de/modeling/glycomapsdb/...
  28. ncbi Binding properties of a mannose-specific lectin from the snowdrop (Galanthus nivalis) bulb
    N Shibuya
    Department of Biological Chemistry, University of Michigan, Ann Arbor 48109
    J Biol Chem 263:728-34. 1988
    ..Glycopeptides which carry Man(alpha 1-3)Man units were retarded on the immobilized GNA column whereas those lacking this unit or with hybrid type glycan chains were not retarded on the column...
  29. pmc Carbohydrate-pi interactions: what are they worth?
    Zachary R Laughrey
    Department of Chemistry, CB 3290, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Am Chem Soc 130:14625-33. 2008
    ..These findings demonstrate the significance of carbohydrate-pi interactions within biological systems and also their utility as a molecular recognition element in designed systems...
  30. ncbi Bacterial lipopolysaccharides and innate immunity
    C Alexander
    Department of Immunochemistry and Biochemical Microbiology, Centre of Medicine and Bio-Sciences, Borstel, Germany
    J Endotoxin Res 7:167-202. 2001
    ....
  31. ncbi Predicting the molecular shape of polysaccharides from dynamic interactions with water
    Andrew Almond
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU United Kingdom
    Glycobiology 13:255-64. 2003
    ..Therefore an intriguing correlation between chemical composition, water organization, polymer properties, and biological function is proposed...
  32. doi Analysis of the human seminal plasma glycome reveals the presence of immunomodulatory carbohydrate functional groups
    Poh Choo Pang
    Division of Molecular Biosciences, Faculty of Natural Sciences, Imperial College London, SW7 2AZ, United Kingdom
    J Proteome Res 8:4906-15. 2009
    ..In summary, the glycosylation profile of seminal plasma glycoproteins is consistent with the modulation of the adaptive but not the innate arm of the human immune response...
  33. doi Why structurally different cyclic peptides can be glycomimetics of the HNK-1 carbohydrate antigen
    Anirban Bhunia
    Institut für Biochemie und Endokrinologie, Veterinrmedizinische Fakultät, Justus Liebig Universitat Giessen, Frankfurter Str 100, 35392 Giessen, Germany
    J Am Chem Soc 132:96-105. 2010
    ....
  34. ncbi Hydroxymethyl group conformation in saccharides: structural dependencies of (2)J(HH), (3)J(HH), and (1)J(CH) spin-spin coupling constants
    Roland Stenutz
    Department of Chemistry, Swedish University of Agricultural Sciences, P O Box 7015, SE 750 07 Uppsala, Sweden
    J Org Chem 67:949-58. 2002
    ..New equations pertaining to (2)J(HH) and (3)J(HH) have been applied to the analysis of hydroxymethyl group J-couplings in several mono- and oligosaccharides, yielding information on C5-C6 and/or C6-O6 rotamer populations...
  35. ncbi Immune response to Thomsen-Friedenreich disaccharide and glycan engineering
    Fernando J Irazoqui
    CIQUIBIC CONICET Department of Biological Chemistry, Faculty of Chemical Sciences, National University of Cordoba, Ciudad Universitaria, Cordoba, Argentina
    Immunol Cell Biol 83:405-12. 2005
    ..We propose the term 'glycan engineering' for this approach. Such engineering of TFD should reduce the flexibility of its glycan moiety and thereby enhance its stability, rigidity and immunogenicity...
  36. ncbi Structure and conformation of complex carbohydrates of glycoproteins, glycolipids, and bacterial polysaccharides
    C A Bush
    Department of Chemistry and Biochemistry, University of Maryland, Baltimore 21250, USA
    Annu Rev Biophys Biomol Struct 28:269-93. 1999
    ....
  37. ncbi The fucose-binding lectin from Ralstonia solanacearum. A new type of beta-propeller architecture formed by oligomerization and interacting with fucoside, fucosyllactose, and plant xyloglucan
    Nikola Kostlánová
    National Centre for Biomolecular Research and Department of Biochemistry, Masaryk University, Brno 611 37, Czech Republic
    J Biol Chem 280:27839-49. 2005
    ..Crystals were also obtained for a mutated lectin complexed with a fragment of xyloglucan, a fucosylated polysaccharide from the primary cell wall of plants, which may be the biological target of the lectin...
  38. pmc Stage-specific embryonic antigens (SSEA-3 and -4) are epitopes of a unique globo-series ganglioside isolated from human teratocarcinoma cells
    R Kannagi
    EMBO J 2:2355-61. 1983
    ..This antigenic conversion suggests that a shift of glycolipid synthesis from globo-series to lacto-series glycolipids occurs during differentiation of human teratocarcinoma and perhaps of pre-implantation mouse embryos...
  39. doi Highly polar carbohydrates stack onto DNA duplexes via CH/π interactions
    Ricardo Lucas
    Department of Bioorganic Chemistry, Instituto de Investigaciones Químicas, CSIC Universidad de Sevilla, Americo Vespucio, 49, 41092 Sevilla, Spain
    J Am Chem Soc 133:1909-16. 2011
    ..These results reveal carbohydrate-DNA base stacking as a potential recognition motif to be used in drug design, supramolecular chemistry, or biobased nanomaterials...
  40. pmc Development of an annotated library of neutral human milk oligosaccharides
    Shuai Wu
    Department of Chemistry, University of California, Davis, California 95616, USA
    J Proteome Res 9:4138-51. 2010
    ..A library with 45 neutral OS structures has been constructed. The structures include information regarding the epitopes such as Lewis type, as well as information regarding the secretor status...
  41. pmc Annotation of a serum N-glycan library for rapid identification of structures
    Danielle Aldredge
    Department of Chemistry, University of California, Davis, California 95616, United States
    J Proteome Res 11:1958-68. 2012
    ..This database is steadily growing and will be used to rapidly identify glycans in unknown biological samples...
  42. doi Quantification of binding affinities of essential sugars with a tryptophan analogue and the ubiquitous role of C-H···π interactions
    Manju Kumari
    Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India
    Phys Chem Chem Phys 13:6517-30. 2011
    ....
  43. ncbi B3LYP/6-311++G** study of alpha- and beta-D-glucopyranose and 1,5-anhydro-D-glucitol: 4C1 and 1C4 chairs, (3,O)B and B(3,O) boats, and skew-boat conformations
    M Appell
    Plant Polymer Research, USDA, ARS, National Center for Agricultural Utilization Research, 1815 N University St, Peoria, IL 61604, USA
    Carbohydr Res 339:537-51. 2004
    ..Other boat and skew-boat forms are described. The beta-anomer boats retained their starting conformations, with the exception of the beta-tg-(3,O)B boat that moved to a skew form upon optimization...
  44. doi Interfering with the sugar code: design and synthesis of oligosaccharide mimics
    Anna Bernardi
    Dipartimento di Chimica Organica e Industriale, Universita degli Studi di Milano, via Venezian 21, Milan, Italy
    Chemistry 14:7434-41. 2008
    ..Attempts to design and prepare glycomimetic inhibitors of well-known target lectins (cholera toxin, DC-SIGN) are reviewed in this concept paper...
  45. pmc Multiple modes of binding enhance the affinity of DC-SIGN for high mannose N-linked glycans found on viral glycoproteins
    Hadar Feinberg
    Departments of Structural Biology and Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 282:4202-9. 2007
    ....
  46. doi Pyranose ring transition state is derived from cellobiohydrolase I induced conformational stability and glycosidic bond polarization
    Christopher B Barnett
    Scientific Computing Research Unit and Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa
    J Am Chem Soc 132:12800-3. 2010
    ..Furthermore, for the (4)H(3) conformation in the catalytic binding domain, there is significant electronic rearrangement that drives the structure toward the transition state of the glycosylation reaction...
  47. pmc Residual dipolar coupling investigation of a heparin tetrasaccharide confirms the limited effect of flexibility of the iduronic acid on the molecular shape of heparin
    Lan Jin
    School of Chemistry, University of Edinburgh, Edinburgh, Scotland
    Glycobiology 19:1185-96. 2009
    ..This is in line with conclusions of previous studies based on MD simulations and the analysis of (1)H-(1)H NOEs. Our work therefore demonstrates the effectiveness of RDCs in the conformational analysis of glycosaminoglycans...
  48. doi NMR and molecular modeling reveal key structural features of synthetic nodulation factors
    Maria A Morando
    Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Glycobiology 21:824-33. 2011
    ..Collected structural data could be used in the future to rationalize and understand their biological activity and affinity toward a putative receptor...
  49. ncbi Calorimetric analysis of the binding of lectins with overlapping carbohydrate-binding ligand specificities
    M C Chervenak
    Department of Chemistry, Duke University, Durham, North Carolina 27708 0346, USA
    Biochemistry 34:5685-95. 1995
    ..Our studies clearly demonstrate that, despite their common affinity for the mannose trisaccharide, the three lectins bind oligosaccharides very differently...
  50. doi Glycan flexibility: insights into nanosecond dynamics from a microsecond molecular dynamics simulation explaining an unusual nuclear Overhauser effect
    Jens Landström
    Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, S 106 91 Stockholm, Sweden
    Carbohydr Res 345:330-3. 2010
    ..The results obtained from the MD simulation underscore the predictive power of molecular simulations in studies of biomolecular systems and also explain an unusual nuclear Overhauser effect originating from conformational exchange...
  51. pmc Proteoglycomics: recent progress and future challenges
    Mellisa Ly
    Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, New York, USA
    OMICS 14:389-99. 2010
    ..Unique challenges in the characterization of glycosaminoglycan component of proteoglycans are discussed, with emphasis on the many analytical tools used and the types of information they provide...
  52. ncbi Neutral N-glycan patterns of the gastropods Limax maximus, Cepaea hortensis, Planorbarius corneus, Arianta arbustorum and Achatina fulica
    Martin Gutternigg
    Department of Chemistry, University of Natural Resources and Applied Life Sciences Vienna, Muthgasse 18, 1190 Vienna, Austria
    Glycoconj J 24:475-89. 2007
    ..The detailed knowledge of this very complex glycosylation system of the gastropods will be a valuable tool to understand the principle rules of glycosylation in all organisms...
  53. ncbi Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR
    H Feinberg
    Department of Structural Biology, University School of Medicine, Stanford, CA 94305, USA
    Science 294:2163-6. 2001
    ....
  54. ncbi Interactions of hepatocyte growth factor/scatter factor with various glycosaminoglycans reveal an important interplay between the presence of iduronate and sulfate density
    Krista R Catlow
    Cancer Research UK Glyco Oncology Group, School of Cancer and Imaging Sciences, Paterson Institute for Cancer Research, University of Manchester, Manchester M20 4BX, United Kingdom
    J Biol Chem 283:5235-48. 2008
    ....
  55. ncbi IgG-Fc-mediated effector functions: molecular definition of interaction sites for effector ligands and the role of glycosylation
    R Jefferis
    Department of Immunology, Medical School, University of Birmingham, Edgbaston, UK
    Immunol Rev 163:59-76. 1998
    ....
  56. ncbi Sweet spots in functional glycomics
    James C Paulson
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nat Chem Biol 2:238-48. 2006
    ....
  57. ncbi Ovarian cancer is associated with changes in glycosylation in both acute-phase proteins and IgG
    Radka Saldova
    Department of Biochemistry, Oxford Glycobiology Institute, University of Oxford, Oxford, UK
    Glycobiology 17:1344-56. 2007
    ....
  58. ncbi Specific band observed in VCD predicts the anomeric configuration of carbohydrates
    Kenji Monde
    Division of Biological Sciences, Graduate School of Science, Frontier Research Center for Post Genomic Science and Technology, Hokkaido University, Kita ku, Sapporo 001 0021, Japan
    J Am Chem Soc 126:9496-7. 2004
    ..As applications of this band, the VCD studies of the maltose-cellobiose mixture and the monitoring of the amyloglucosidase reaction were examined...
  59. ncbi Relationship between structure and three-bond proton-proton coupling constants in glycosaminoglycans
    M Hricovini
    Institute of Chemistry, Slovak Academy of Sciences, 845 38 Bratislava, Slovakia
    Carbohydr Res 342:779-83. 2007
    ..The population of conformers in heparin and other biologically active GAGs has also been estimated using the computed coupling constants...
  60. doi Modelling of beta-D-glucopyranose ring distortion in different force fields: a metadynamics study
    Vojtech Spiwok
    Department of Biochemistry and Microbiology, Institute of Chemical Technology Prague, Technicka 3, Prague, Czech Republic
    Carbohydr Res 345:530-7. 2010
    ..Comparison of free and potential surfaces is also provided for vacuum calculations...
  61. pmc Conformation of heparin pentasaccharide bound to antithrombin III
    M Hricovini
    Institute of Chemistry, Slovak Academy of Sciences, Dubravska cesta 9, 842 38 Bratislava, Slovakia
    Biochem J 359:265-72. 2001
    ..Evidence is also provided that the protein drives the conformation of the 2-O-sulphated iduronic acid residue towards the skewed (2)S(0) form...
  62. doi Conformational properties of glucose-based disaccharides investigated using molecular dynamics simulations with local elevation umbrella sampling
    Lovorka Perić-Hassler
    Laboratory of Physical Chemistry, ETH Zurich, ETH Honggerberg, HCI, CH 8093 Zurich, Switzerland
    Carbohydr Res 345:1781-801. 2010
    ..The calculated average values of the glycosidic torsional angles agree well with the available experimental data, providing validation for the force-field and simulation methodology employed...
  63. ncbi Hyaluronan chain conformation and dynamics
    Sara Furlan
    Department of Biochemistry, Biophysics and Macromolecular Chemistry, UdR INSTM, University of Trieste, I 34127 Trieste, Italy
    Carbohydr Res 340:959-70. 2005
    ..Topological features and dimensional properties are related to the structural determinants by using classical computational methods of molecular mechanics and Monte Carlo simulation...
  64. ncbi Isomer and glycomer complexities of core GlcNAcs in Caenorhabditis elegans
    Andrew J Hanneman
    Department of Chemistry, Center for Structural Biology, University of New Hampshire, Durham, NH 03824, USA
    Glycobiology 16:874-90. 2006
    ..All CCM structures, including multiple isomers, were determined without chromatography by gas-phase disassembly (MS(n)) in Paul and linear ion trap (IT) instruments...
  65. ncbi High-yielding and controlled dissociation of glycosides producing B- and C-ion species under collision-induced dissociation MS/MS conditions and use in structural determination
    Katsuhiko Suzuki
    Mitsubishi Kagaku Institute of Life Sciences MITILS, 11 Minamiooya, Machida shi, Tokyo 194 8511, Japan
    Anal Chem 79:9022-9. 2007
    ....
  66. doi Energy-resolved structural details obtained from gangliosides
    Yuki Shioiri
    Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4529 Nagatsuta cho, Midori ku, Yokohama 226 0018, Japan
    Anal Chem 81:139-45. 2009
    ..It was suggested that this information will be useful in determining the structures of their precursor gangliosides...
  67. ncbi CD1d-lipid-antigen recognition by the semi-invariant NKT T-cell receptor
    Natalie A Borg
    The Protein Crystallography Unit, ARC Centre of Excellence in Structural and Functional Microbial Genomics, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia
    Nature 448:44-9. 2007
    ..These findings provide direct insight into how a T-cell receptor recognizes a lipid-antigen-presenting molecule of the immune system...
  68. pmc SWEET-DB: an attempt to create annotated data collections for carbohydrates
    Alexander Loss
    University Hildesheim, Institute of Physics and Technical Informatics, Marienburger Platz 22, 31141 Hildesheim, Germany
    Nucleic Acids Res 30:405-8. 2002
    ..A detailed online tutorial is available at http://www.dkfz.de/spec2/sweetdb/nar/...
  69. doi Glycomic analysis of N-linked carbohydrate epitopes from CD24 of mouse brain
    Christina Bleckmann
    Institute of Biochemistry, University of Giessen, Friedrichstrasse 24, D 35392 Giessen, Germany
    J Proteome Res 8:567-82. 2009
    ....
  70. pmc Glycoconjugate Data Bank: Structures--an annotated glycan structure database and N-glycan primary structure verification service
    Taku Nakahara
    Laboratory of Advanced Chemical Biology, Graduate School of Advanced Life Science, Frontier Research Center for the Post Genomic Science and Technology, Hokkaido University, Sapporo, Japan
    Nucleic Acids Res 36:D368-71. 2008
    ..The results of getCARBO are stored and presented in GDB:Structures...
  71. ncbi Molecular organization of the alkali-insoluble fraction of Aspergillus fumigatus cell wall
    T Fontaine
    Laboratoire des Aspergillus, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
    J Biol Chem 275:27594-607. 2000
    ..The data obtained suggested that the branching of beta-1,3-glucan is an early event in the construction of the cell wall, resulting in an increase of potential acceptor sites for chitin, galactomannan, and the linear beta-1,3/1,4-glucan...
  72. ncbi Conformational analysis of a dermatan sulfate-derived tetrasaccharide by NMR, molecular modeling, and residual dipolar couplings
    Alba Silipo
    Centro de Investigaciones Biologicas, CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain
    Chembiochem 9:240-52. 2008
    ..Differences in the shapes of species with the IdoA in skew and in chair conformations and in the distribution of the sulfate groups have also been highlighted...
  73. ncbi Hyaluronan: the local solution conformation determined by NMR and computer modeling is close to a contracted left-handed 4-fold helix
    Andrew Almond
    Faculty of Life Sciences, University of Manchester, Manchester Interdisciplinary Biocentre, Princess Street, Manchester, M1 7ND, UK
    J Mol Biol 358:1256-69. 2006
    ..This representation can be used as a basis for modeling the association between HA and proteins, which will elucidate important aspects of extracellular matrix assembly...
  74. ncbi Conformation of glycosaminoglycans by ion mobility mass spectrometry and molecular modelling
    Lan Jin
    University of Edinburgh, School of Chemistry, Joseph Black Building, West Mains Rd, Edinburgh, UK EH9 3JJ
    Phys Chem Chem Phys 7:3464-71. 2005
    ..Interestingly, the gas phase conformations of the three tetrasaccharide ions with different primary structures were significantly different...
  75. ncbi "Glyco-peakfinder"--de novo composition analysis of glycoconjugates
    Kai Maass
    Institute of Biochemistry, Faculty of Medicine, University of Giessen, Germany
    Proteomics 7:4435-44. 2007
    ..To provide access to known carbohydrate structures a "composition search" in the open access database GLYCOSCIENCES.de can be performed. The service is available at the URL: www.eurocarbdb.org/applications/ms-tools...
  76. doi Depiction of the forces participating in the 2-O-sulfo-alpha-L-iduronic acid conformational preference in heparin sequences in aqueous solutions
    Laercio Pol-Fachin
    Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Av Bento Goncalves 9500, CP 15005, Porto Alegre 91500 970, RS, Brazil
    Carbohydr Res 343:1435-45. 2008
    ..001) with the expected conformational equilibrium for this residue in solution. This behavior explains the known effect of different heparin compositions, at the monosaccharide level, on IdoA2S conformation in biological solutions...
  77. ncbi Conformational flexibility of a synthetic glycosylaminoglycan bound to a fibroblast growth factor. FGF-1 recognizes both the (1)C(4) and (2)S(O) conformations of a bioactive heparin-like hexasaccharide
    Angeles Canales
    Centro de Investigaciones Biologicas, CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain, Instituto de Investigaciones Quimicas, CSIC, Americo Vespucio s n, Sevilla, Spain
    J Am Chem Soc 127:5778-9. 2005
    ..Therefore, this case is different than that described for the controversial recognition of heparin-like saccharides by AT-III, which seems to recognize just one conformation of the iduronic acid residues...
  78. pmc Lack of L-iduronic acid in heparan sulfate affects interaction with growth factors and cell signaling
    Juan Jia
    Department of Medical Biochemistry and Microbiology, University of Uppsala, The Biomedical Center, Box 582, SE 751 23 Uppsala, Sweden
    J Biol Chem 284:15942-50. 2009
    ..These findings correlate defective function of growth factors with their mode of HS interaction and may help explain the partly modest organ phenotypes observed after genetic ablation of selected enzymes in HS biosynthesis...
  79. pmc Conformational transitions induced in heparin octasaccharides by binding with antithrombin III
    Marco Guerrini
    G Ronzoni Institute for Chemical and Biochemical Research, Via G Colombo 81, 20133 Milan, Italy
    Biochem J 399:191-8. 2006
    ..Thus, for each AT binding sequence longer than AGA*IA, the interactions with the protein could differ and give to each heparin fragment a specific biological response...
  80. ncbi B3LYP/6-311++G** study of structure and spin-spin coupling constant in methyl 2-O-sulfo-alpha-L-iduronate
    Milos Hricovini
    Institute of Chemistry, Slovak Academy of Sciences, 845 38 Bratislava, Slovakia
    Carbohydr Res 341:2575-80. 2006
    ..The influence of the charged groups upon the magnitudes of spin-spin coupling constants is also discussed...
  81. ncbi Glycan classification with tree kernels
    Yoshihiro Yamanishi
    Bioinformatics Center, Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto 611 0011, Japan
    Bioinformatics 23:1211-6. 2007
    ..Recently, comprehensive data about the structure and function of glycans have been accumulated, therefore the need for methods and algorithms to analyze these data is growing fast...
  82. pmc Biophysical studies of DNA modified with conformationally constrained nucleotides: comparison of 2'-exo (north) and 3'-exo (south) 'locked' templates
    Melissa Maderia
    Laboratory of Medicinal Chemistry, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Nucleic Acids Res 35:1978-91. 2007
    ..Our data and those of others suggest that although DNA can tolerate modifications with RNA-like (North) nucleotides, a more complicated spectrum of changes emerges with modifications restricted to South (DNA-like) puckers...
  83. ncbi Interaction of heparins with fibroblast growth factors: conformational aspects
    Marco Guerrini
    G Ronzoni, Institute for Chemical and Biochemical Research, Milan, Italy
    Curr Pharm Des 13:2045-56. 2007
    ..Current NMR and molecular modelling studies are being extended to longer heparin oligosaccharides as well as to heparins with "glycol-split" residues along their chains...
  84. ncbi Conformational preferences of chondroitin sulfate oligomers using partially oriented NMR spectroscopy of 13C-labeled acetyl groups
    Fei Yu
    Complex Carbohydrate Research Center and Department of Chemistry, University of Georgia, Athens, Georgia 30602 4712, USA
    J Am Chem Soc 129:13288-97. 2007
    ..The geometry derived is compared to that for similar molecules that have been reported in the literature, and prospects for use of the new types of data in the study of protein-bound oligosaccharides are discussed...
  85. ncbi Conformational studies on five octasaccharides isolated from chondroitin sulfate using NMR spectroscopy and molecular modeling
    Veronique Blanchard
    Bijvoet Center, Department of Bio Organic Chemistry, Utrecht University, Padualaan 8, NL 3584 CH Utrecht, The Netherlands
    Biochemistry 46:1167-75. 2007
    ....
  86. ncbi Comparison of the methods for profiling glycoprotein glycans--HUPO Human Disease Glycomics/Proteome Initiative multi-institutional study
    Yoshinao Wada
    Osaka Medical Center and Research Institute for Maternal and Child Health, 840 Murodo cho, Izumi, Osaka 594 1101, Japan
    Glycobiology 17:411-22. 2007
    ....
  87. ncbi Structures of Streptococcus pneumoniae hyaluronate lyase in complex with chondroitin and chondroitin sulfate disaccharides. Insights into specificity and mechanism of action
    Daniel J Rigden
    Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
    J Biol Chem 278:50596-606. 2003
    ..The more efficient processive degradation mechanism has come to be preferred for the unsulfated substrate hyaluronan...
  88. ncbi B3LYP/6-311++G* * study of structure and spin-spin coupling constant in heparin disaccharide
    M Hricovini
    Institute of Chemistry, Slovak Academy of Sciences, 845 38 Bratislava, Slovakia
    Carbohydr Res 342:1350-6. 2007
    ..Influences of the charged groups upon the magnitudes of spin-spin coupling constants are also discussed...
  89. ncbi Complete assignment of hyaluronan oligosaccharides up to hexasaccharides
    Charles D Blundell
    Faculty of Life Sciences, Manchester Interdisciplinary Biocentre, University of Manchester, Princess Street, Manchester M1 7DN, UK
    Carbohydr Res 341:2803-15. 2006
    ..These assignments now allow resolved, unambiguous structural restraints to be acquired on this oligosaccharide and extrapolated to models for the solution conformation of the polymer...
  90. doi Glycomics of bone marrow-derived mesenchymal stem cells can be used to evaluate their cellular differentiation stage
    Annamari Heiskanen
    Glykos Finland Ltd, Helsinki, Finland
    Glycoconj J 26:367-84. 2009
    ..Characteristic glycosylation features that appeared in differentiated osteoblasts included abundant sulfate ester modifications. The results show that glycosylation analysis can be used to evaluate MSC differentiation state...
  91. pmc Solution structures of chemoenzymatically synthesized heparin and its precursors
    Zhenqing Zhang
    Department of Chemistry, Rensselaer Polytechnic Institute, Troy, New York 12180, USA
    J Am Chem Soc 130:12998-3007. 2008
    ..Stable isotope-labeled heparin was indistinguishable from heparin derived from animal tissues and is a novel reagent for studying the interaction of heparin with proteins...
  92. ncbi Control of glycoprotein synthesis. Kinetic mechanism, substrate specificity, and inhibition characteristics of UDP-N-acetylglucosamine:alpha-D-mannoside beta 1-2 N-acetylglucosaminyltransferase II from rat liver
    B Bendiak
    J Biol Chem 262:5784-90. 1987
    ....
  93. ncbi Conformational studies of oligosaccharides and glycopeptides: complementarity of NMR, X-ray crystallography, and molecular modelling
    Mark R Wormald
    Oxford Glycobiology Institute, Department of Biochemistry, Oxford University, South Parks Road, Oxford OX1 3QU, United Kingdom
    Chem Rev 102:371-86. 2002
  94. ncbi Structural determination of five novel tetrasaccharides containing 3-O-sulfated D-glucuronic acid and two rare oligosaccharides containing a beta-D-glucose branch isolated from squid cartilage chondroitin sulfate E
    Akiko Kinoshita-Toyoda
    Department of Biochemistry, Kobe Pharmaceutical University, Higashinada ku, Kobe 658 8558, Japan
    Biochemistry 43:11063-74. 2004
    ..Approximately 5 mol % of all disaccharide units were substituted by Glc in the CS-E preparation used...
  95. pmc Discovery and characterization of sialic acid O-acetylation in group B Streptococcus
    Amanda L Lewis
    Division of Biological Sciences, Glycobiology Research and Training Center, University of California at San Diego, La Jolla, CA 92093 0687, USA
    Proc Natl Acad Sci U S A 101:11123-8. 2004
    ..Thus, our discovery has important implications for GBS pathogenicity, immunogenicity, and vaccine design...
  96. ncbi Bioinformatics for glycomics: status, methods, requirements and perspectives
    Claus Wilhelm Von der Lieth
    German Cancer Research Center, Central Spectroscopic Department B090, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Brief Bioinform 5:164-78. 2004
    ..The upcoming glycomics should accept that unrestricted dissemination of scientific data accelerates scientific findings and initiates a number of new initiatives to explore the data...
  97. ncbi Tracking alignment from the moment of inertia tensor (TRAMITE) of biomolecules in neutral dilute liquid crystal solutions
    Hugo F Azurmendi
    Department of Chemistry and Biochemistry, University of Maryland Baltimore County, Baltimore, MD 21250, USA
    J Am Chem Soc 124:2426-7. 2002
    ..Examples on proteins and oligosaccharides are presented which cover a wide range of sizes and shapes, along with a scheme for the application of the method to the analysis of flexible molecules...
  98. ncbi Conformation of the hexasaccharide repeating subunit from the Vibrio cholerae O139 capsular polysaccharide
    Jacob Adeyeye
    Department of Chemistry and Biochemistry, University of Maryland Baltimore County, Baltimore, Maryland 21250, USA
    Biochemistry 42:3979-88. 2003
    ..cholerae strain, is not a "conformational epitope" requiring a certain critical size for antigenicity as has been reported for several other bacterial capsular antigens...
  99. ncbi Trehalose-based oligosaccharides isolated from the cytoplasm of Mycobacterium smegmatis. Relation to trehalose-based oligosaccharides attached to lipid
    Masaya Ohta
    Department of Biochemistry, Fukuyuma University, Japan
    Eur J Biochem 269:3142-9. 2002
    ....
  100. ncbi Rapid generation of a representative ensemble of N-glycan conformations
    Martin Frank
    DKFZ German Cancer Research Centre, Molecular Modelling, INF 280, 69120 Heidelberg, Germany
    In Silico Biol 2:427-39. 2002
    ..A web interface has been established (http://www.dkfz.de/spec/glydict/), which enables to input any N-glycan of interest and to receive an ensemble of generated conformations within a few minutes...
  101. ncbi Purification and cDNA cloning of porcine brain GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1-->6fucosyltransferase
    N Uozumi
    Department of Biochemistry, Osaka University Medical School, 2 2 Yamadaoka, Suita, Osaka 565, Japan
    J Biol Chem 271:27810-7. 1996
    ..No sequence homology was found with other previously cloned fucosyltransferases, but the enzyme appears to be a type II transmembrane protein like the other glycosyltransferases...

Research Grants142 found, 100 shown here

  1. A Thermo Electron LTQ Mass Spectrometer
    Joseph Zaia; Fiscal Year: 2006
    ..The costs of instrument operation, supplies, and service contract will be shared by the users, as stated in their support letters. The salary for the instrument operator will be provided by the Dean of BU School of Medicine. ..
  2. Glycosaminoglycan-Protein Binding
    Joseph Zaia; Fiscal Year: 2006
    ..abstract_text> ..
  3. Host Response in S. aureus Infections: Role of T cells
    Arthur Tzianabos; Fiscal Year: 2006
    ..aureus infections. This information may reveal new strategies for the prevention or treatment of S. aureus infections through immunomodulation of the host response to this organism. ..
  4. TOTAL SYNTHESIS OF AZASPIRACIDS
    K Nicolaou; Fiscal Year: 2006
    ..g. lung, liver, spleen and lymphocyte damage as well as cancer) health hazards. The project is also expected to advance our knowledge in chemical synthesis and impact favorably the drug discovery and development process. ..
  5. TOTAL SYNTHESIS OF NATURAL PRODUCTS
    K Nicolaou; Fiscal Year: 2002
    ..3] sigmatropic rearrangement and a radical based ring closure to form the bicyclic skeleton. ..
  6. Enabling Technologies for Combinatorial Chemistry
    K Nicolaou; Fiscal Year: 2005
    ..abstract_text> ..
  7. Chemical Synthesis of Beta Manno-and Rhamnopyranosides
    David Crich; Fiscal Year: 2005
    ..Accordingly, it is necessary that any truly valuable method be demonstrated to be readily transferable between the two phases. ..
  8. FASEB Summer Conference on Microbial Polysaccharides
    Arthur Tzianabos; Fiscal Year: 2004
    ..This meeting will provide a unique environment for scientific exchange between a diverse group of investigators in the area of microbial polysaccharides. ..
  9. TOTAL SYNTHESIS OF APOPTOLIDIN
    K Nicolaou; Fiscal Year: 2004
    ..The proposed work is expected to have significant impact in the area of cancer chemotherapy and should provide enabling technologies and tools for biology and medicine. ..
  10. Methods and Mechanisms in Carbohydrate Chemistry
    David Crich; Fiscal Year: 2003
    ..It is hoped that an enhanced understanding of the poor reactivity of these species will enable the development of protecting groups and conditions to circumvent it. ..
  11. TOTAL SYNTHESIS OF THIOSTREPTON
    K Nicolaou; Fiscal Year: 2005
    ..The disease areas likely to benefit most from the proposed investigations are bacterial-caused diseases and malaria. ..
  12. SYNTHESIS OF ANTIBIOTICS
    K C Nicolaou; Fiscal Year: 2010
    ..abstract_text> ..
  13. Chemical Synthesis of Beta-Manno and Rehamnopyranosides
    David Crich; Fiscal Year: 2007
    ....
  14. SYNTHESIS OF ANTICANCER AGENTS
    K C Nicolaou; Fiscal Year: 2010
    ..abstract_text> ..
  15. SYNTHESIS OF ANTIBIOTICS
    K Nicolaou; Fiscal Year: 2007
    ....
  16. Synthesis of Marine Neurotoxins
    K Nicolaou; Fiscal Year: 2007
    ..The project is also expected to significantly advance our knowledge in chemical synthesis, chemical biology, and medicine ..
  17. Methods and Mechanisms in Carbohydrate Chemistry
    David Crich; Fiscal Year: 2007
    ....
  18. TOTAL SYNTHESIS OF AZADIRACHTIN
    K Nicolaou; Fiscal Year: 2007
    ..The proposed work is expected to impact the general areas of pharmaceutical and agricultural research, and infectious diseases in particular, through discoveries in synthetic organic chemistry and chemical biology. ..
  19. RHIZOBIAL LIPOPOLYSACCHARIDES ESSENTIAL FOR INFECTION
    Russell Carlson; Fiscal Year: 2009
    ..create specific LPS mutants and characterize their structural and symbiotic phenotypes, and (3.) determine how a 27OHC28:0-lacking mutant, acpXL::kan, is able to activate an alternative mechanism within the host cell. ..
  20. Novel High-throghput Assay:Angiogenesis Inhibitors (RMI)
    Sunil David; Fiscal Year: 2004
    ..Promising compounds will be examined in greater detail with respect to details of the physical interactions with heparin. Further biological activity will be ascertained in chicken chorioallantoic membrane assays. ..
  21. Identifying and Studying RNA Loop-Small Molecule Interactions
    MATTHEW DISNEY; Fiscal Year: 2009
    ....
  22. Gram-Negative Sepsis: Pharmacophore-Based Therapeutics
    Sunil David; Fiscal Year: 2007
    ..abstract_text> ..
  23. Role of Sialidase in Pulmonary Host Defenses and Acute Lung Injury
    Alan Cross; Fiscal Year: 2010
    ..Since inhibitors of sialidase are commercially available, these studies will provide the experimental rationale for testing a new therapeutic approach to the treatment of lung injury. ..
  24. Immunity of Schistosome Glycoconjugates
    Richard Cummings; Fiscal Year: 2007
    ..These studies will provide important new insights into the immune responses to glycan antigens in parasitic infections and test the potential of glycan-protein conjugates as vaccine candidates for parasitic helminths. ..
  25. RHIZOBIAL LIPOPOLYSACCHARIDES ESSENTIAL FOR INFECTION
    Russell Carlson; Fiscal Year: 2007
    ..create specific LPS mutants and characterize their structural and symbiotic phenotypes, and (3.) determine how a 27OHC28:0-lacking mutant, acpXL::kan, is able to activate an alternative mechanism within the host cell. ..
  26. RHIZOBIAL LIPOPOLYSACCHARIDES ESSENTIAL FOR INFECTION
    Russell W Carlson; Fiscal Year: 2010
    ..create specific LPS mutants and characterize their structural and symbiotic phenotypes, and (3.) determine how a 27OHC28:0-lacking mutant, acpXL::kan, is able to activate an alternative mechanism within the host cell. ..
  27. INTERFERON Y MEDIATES ANTI E COLI DEFENSES AND SEPSIS
    Alan Cross; Fiscal Year: 2001
    ..The demonstration of a spectrum of responses to LPS in these studies may identify the earliest changes in cytokine responses that predict the development of sepsis. ..
  28. STRUCTURAL DETERMINATION OF THE LPS FROM RHIZOBIUM
    Russell Carlson; Fiscal Year: 1993
    ..Based on the results of this proposed work, it should (in the future) be able to identify the genes required for these LPS alterations and to determined how their expression is regulated by the host plant...