electrochemistry

Summary

Summary: The study of chemical changes resulting from electrical action and electrical activity resulting from chemical changes.

Articles from Journal RESEARCH

Top Publications

  1. ncbi Protein electrochemistry using aligned carbon nanotube arrays
    J Justin Gooding
    School of Chemical Sciences, The University of New South Wales, Sydney, NSW 2052, Australia
    J Am Chem Soc 125:9006-7. 2003
  2. ncbi Crystal structure of a mammalian voltage-dependent Shaker family K+ channel
    Stephen B Long
    Howard Hughes Medical Institute, Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 309:897-903. 2005
  3. ncbi Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution
    Y Zhou
    Department of Molecular Biophysics and Biochemistry, Yale University, 260 Whitney Avenue, New Haven, Connecticut 06520, USA
    Nature 414:43-8. 2001
  4. ncbi Glucose oxidase-graphene-chitosan modified electrode for direct electrochemistry and glucose sensing
    Xinhuang Kang
    Pacific Northwest National Laboratory, Richland, WA 99352, USA
    Biosens Bioelectron 25:901-5. 2009
  5. ncbi Sequence-specific detection of femtomolar DNA via a chronocoulometric DNA sensor (CDS): effects of nanoparticle-mediated amplification and nanoscale control of DNA assembly at electrodes
    Jiong Zhang
    Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China
    J Am Chem Soc 128:8575-80. 2006
  6. ncbi Electrospinning of polymeric nanofibers for tissue engineering applications: a review
    Quynh P Pham
    Department of Bioengineering, Rice University, Houston, Texas 77251 1892, USA
    Tissue Eng 12:1197-211. 2006
  7. ncbi Microbial fuel cells: methodology and technology
    Bruce E Logan
    Hydrogen Energy Center, 212 Sackett Building, Penn State University, University Park, Pennsylvania 16802, USA
    Environ Sci Technol 40:5181-92. 2006
  8. ncbi DNA-templated assembly and electrode attachment of a conducting silver wire
    E Braun
    Department of Physics, Technion Israel Institute of Technology, Haifa
    Nature 391:775-8. 1998
  9. doi Nitrogen-doped graphene and its application in electrochemical biosensing
    Ying Wang
    Department of Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Tsinghua University, Beijing 100084, People s Republic of China
    ACS Nano 4:1790-8. 2010
  10. doi Luminescent cyclometalated iridium(III) polypyridine indole complexes--synthesis, photophysics, electrochemistry, protein-binding properties, cytotoxicity, and cellular uptake
    Jason Shing Yip Lau
    Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, People s Republic of China
    Inorg Chem 48:708-18. 2009

Research Grants

  1. ELECTROANALYSIS OF NEUROTRANSMITTERS AND MODULATORS
    Robert Wightman; Fiscal Year: 2005
  2. ELECTROCHEMICAL DNA-BASED SENSORS
    JACQUELINE BARTON; Fiscal Year: 2009
  3. ELECTROCHEMICAL DNA-BASED SENSORS
    Jacqueline K Barton; Fiscal Year: 2010
  4. Low-Coordinate Synthetic Models for Nitrogenase Activity
    Patrick L Holland; Fiscal Year: 2010
  5. The Electrochemistry of Diheme Cytochrome c Peroxidases
    SEAN ELLIOTT; Fiscal Year: 2009
  6. CATECHOLAMINES AND SEROTONIN IN BLOOD PRESSURE CONTROL
    Curt Freed; Fiscal Year: 1990
  7. NITRIC OXIDE INTERACTION WITH INSECT NITROPHORINS
    Frances Walker; Fiscal Year: 2005
  8. NITRIC OXIDE INTERACTION WITH INSECT NITROPHORINS
    Frances Walker; Fiscal Year: 2006
  9. NITRIC OXIDE INTERACTION WITH INSECT NITROPHORINS
    Frances Walker; Fiscal Year: 2004
  10. NITRIC OXIDE INTERACTION WITH INSECT NITROPHORINS
    Frances Walker; Fiscal Year: 2003

Detail Information

Articles from Journal RESEARCH1

Publications348 found, 100 shown here

  1. ncbi Protein electrochemistry using aligned carbon nanotube arrays
    J Justin Gooding
    School of Chemical Sciences, The University of New South Wales, Sydney, NSW 2052, Australia
    J Am Chem Soc 125:9006-7. 2003
    ..The efficiency of the electron transfer through the SWNTs is demonstrated by electrodes modified with tubes cut to different lengths having the same electron-transfer rate constant...
  2. ncbi Crystal structure of a mammalian voltage-dependent Shaker family K+ channel
    Stephen B Long
    Howard Hughes Medical Institute, Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 309:897-903. 2005
    ..Electrostatic properties of the side portals and positions of the T1 domain and beta subunit are consistent with electrophysiological studies of inactivation gating and with the possibility of K+ channel regulation by the beta subunit...
  3. ncbi Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution
    Y Zhou
    Department of Molecular Biophysics and Biochemistry, Yale University, 260 Whitney Avenue, New Haven, Connecticut 06520, USA
    Nature 414:43-8. 2001
    ..This structural change is crucial to the operation of the selectivity filter in the cellular context, where the K+ ion concentration near the selectivity filter varies in response to channel gating...
  4. ncbi Glucose oxidase-graphene-chitosan modified electrode for direct electrochemistry and glucose sensing
    Xinhuang Kang
    Pacific Northwest National Laboratory, Richland, WA 99352, USA
    Biosens Bioelectron 25:901-5. 2009
    Direct electrochemistry of a glucose oxidase (GOD)-graphene-chitosan nanocomposite was studied...
  5. ncbi Sequence-specific detection of femtomolar DNA via a chronocoulometric DNA sensor (CDS): effects of nanoparticle-mediated amplification and nanoscale control of DNA assembly at electrodes
    Jiong Zhang
    Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China
    J Am Chem Soc 128:8575-80. 2006
    ..In addition, this novel DNA sensor showed fairly good reproducibility, stability, and reusability...
  6. ncbi Electrospinning of polymeric nanofibers for tissue engineering applications: a review
    Quynh P Pham
    Department of Bioengineering, Rice University, Houston, Texas 77251 1892, USA
    Tissue Eng 12:1197-211. 2006
    ....
  7. ncbi Microbial fuel cells: methodology and technology
    Bruce E Logan
    Hydrogen Energy Center, 212 Sackett Building, Penn State University, University Park, Pennsylvania 16802, USA
    Environ Sci Technol 40:5181-92. 2006
    ..of MFCs requires knowledge of different scientific and engineering fields, ranging from microbiology and electrochemistry to materials and environmental engineering...
  8. ncbi DNA-templated assembly and electrode attachment of a conducting silver wire
    E Braun
    Department of Physics, Technion Israel Institute of Technology, Haifa
    Nature 391:775-8. 1998
    ..The experiment confirms that the recognition capabilities of DNA can be exploited for the targeted attachment of functional wires...
  9. doi Nitrogen-doped graphene and its application in electrochemical biosensing
    Ying Wang
    Department of Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Tsinghua University, Beijing 100084, People s Republic of China
    ACS Nano 4:1790-8. 2010
    ..The N-doped graphene has further been used for glucose biosensing with concentrations as low as 0.01 mM in the presence of interferences...
  10. doi Luminescent cyclometalated iridium(III) polypyridine indole complexes--synthesis, photophysics, electrochemistry, protein-binding properties, cytotoxicity, and cellular uptake
    Jason Shing Yip Lau
    Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, People s Republic of China
    Inorg Chem 48:708-18. 2009
    ....
  11. doi Electrochemical detection for paper-based microfluidics
    Wijitar Dungchai
    Sensor Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Patumwan, Bangkok, 10330, Thailand
    Anal Chem 81:5821-6. 2009
    ..This study shows the successful integration of paper-based microfluidics and electrochemical detection as an easy-to-use, inexpensive, and portable alternative for point of care monitoring...
  12. ncbi Grafting of gelatin on electrospun poly(caprolactone) nanofibers to improve endothelial cell spreading and proliferation and to control cell Orientation
    Zuwei Ma
    Nanoscience and Nanotechnology Initiative, National University of Singapore
    Tissue Eng 11:1149-58. 2005
    ..The surface-modified PCL nanofibrous material is a potential candidate material in blood vessel tissue engineering...
  13. ncbi Mesoscopic spatial designs of nano- and microfiber meshes for tissue-engineering matrix and scaffold based on newly devised multilayering and mixing electrospinning techniques
    Satoru Kidoaki
    Division of Biomedical Engineering, Graduate School of Medicine, Kyushu University, 3 1 1 Maidashi, Higashiku, Fukuoka City, Fukuoka 812 8582, Japan
    Biomaterials 26:37-46. 2005
    ....
  14. doi The mechanism of electroforming of metal oxide memristive switches
    J Joshua Yang
    Information and Quantum Systems Lab, Hewlett Packard Laboratories, Palo Alto, CA 94304, USA
    Nanotechnology 20:215201. 2009
    ..Better yet, electroforming problems can be largely eliminated by engineering the device structure to remove 'bulk' oxide effects in favor of interface-controlled electronic switching...
  15. ncbi Electrospinning of nano/micro scale poly(L-lactic acid) aligned fibers and their potential in neural tissue engineering
    F Yang
    Department of Mechanical Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117576
    Biomaterials 26:2603-10. 2005
    ..Based on the experimental results, the aligned nanofibrous PLLA scaffold could be used as a potential cell carrier in neural tissue engineering...
  16. ncbi Graphene-based materials in electrochemistry
    Da Chen
    Department of Chemistry, Key Lab of Bioorganic Phosphorus Chemistry and Chemical Biology, Tsinghua University, Beijing 100084, China
    Chem Soc Rev 39:3157-80. 2010
    ..we will describe recent advances in the development of graphene-based materials from the standpoint of electrochemistry. To begin with, electron transfer properties of graphene will be discussed, involving its unusual electronic ..
  17. doi Building better batteries
    M Armand
    LRCS, CNRS UMR 6007, Universite de Picardie Jules Verne, Amiens, France
    Nature 451:652-7. 2008
  18. ncbi Mechanical properties of single electrospun collagen type I fibers
    Lanti Yang
    Polymer Chemistry and Biomaterials, Faculty of Science and Technology and Institute for Biomedical Technology BMTI, University of Twente, P O Box 217, 7500 AE, Enschede, The Netherlands
    Biomaterials 29:955-62. 2008
    ..Cross-linking of the electrospun fibers with glutaraldehyde vapor increased the shear modulus of the fiber from approximately 30 to approximately 50 MPa at ambient conditions...
  19. ncbi Double-codified gold nanolabels for enhanced immunoanalysis
    Adriano Ambrosi
    Nanobioelectronics and Biosensors Group, Institut Catala de Nanotecnologia, Barcelona, Catalonia, Spain
    Anal Chem 79:5232-40. 2007
    ..The developed label and method is versatile, offers enhanced performances, and can be easily extended to other protein detection schemes as well as in DNA analysis...
  20. pmc Electrochemical interrogation of conformational changes as a reagentless method for the sequence-specific detection of DNA
    Chunhai Fan
    Institute for Polymers and Organic Solids, University of California, Santa Barbara, CA 93106, USA
    Proc Natl Acad Sci U S A 100:9134-7. 2003
    ..The E-DNA sensor thus offers the promise of convenient, reusable detection of picomolar DNA...
  21. ncbi Enzymatic biofuel cells for implantable and microscale devices
    Scott Calabrese Barton
    Department of Chemical Engineering, Columbia University, New York, New York 10027, USA
    Chem Rev 104:4867-86. 2004
  22. doi The application of nanofibrous scaffolds in neural tissue engineering
    Haoqing Cao
    Nanyang Technological University, Singapore
    Adv Drug Deliv Rev 61:1055-64. 2009
    ..Both fibrous scaffolds would enhance neurite extension and axon regrowth. These functional nanofibrous scaffolds can serve as powerful tools for neural tissue engineering...
  23. ncbi Morphology-dependent electrochemistry and electrocatalytical activity of cytochrome c
    Haiqing Liu
    Department of Chemistry, Tongji University, Shanghai, PR China
    Langmuir 23:9487-94. 2007
    The morphology-dependent electrochemistry and electrocatalytical activity of cytochrome c (cyt. c) were investigated at pyramidal, rodlike, and spherical gold nanostructures directly electrodeposited onto sputtered gold surfaces...
  24. doi Review: Carbon nanotube based electrochemical sensors for biomolecules
    Christopher B Jacobs
    Dept of Chemistry, University of Virginia, PO Box 400319, Charlottesville, VA 22904, United States
    Anal Chim Acta 662:105-27. 2010
    ..Future challenges for the field include miniaturizing sensors, developing methods to use only a specific nanotube allotrope, and simplifying manufacturing...
  25. ncbi Controlling analyte electrochemistry in an electrospray ion source with a three-electrode emitter cell
    Gary J Van Berkel
    Organic and Biological Mass Spectrometry Group, Chemical Sciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831 6131, USA
    Anal Chem 76:1493-9. 2004
    The inherent electrochemistry occurring at the emitter electrode of an electrospray ion source was effectively controlled by incorporating a three-electrode controlled-potential electrochemical cell into the controlled-current ..
  26. doi Raising the cycling stability of aqueous lithium-ion batteries by eliminating oxygen in the electrolyte
    Jia Yan Luo
    Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Institute of New Energy, Fudan University, Shanghai 200433, China
    Nat Chem 2:760-5. 2010
    ....
  27. doi Luminescent cyclometalated iridium(III) polypyridine di-2-picolylamine complexes: synthesis, photophysics, electrochemistry, cation binding, cellular internalization, and cytotoxic activity
    Pui Kei Lee
    Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, People s Republic of China
    Inorg Chem 50:8570-9. 2011
    ....
  28. doi Membrane-based electrochemical nanobiosensor for Escherichia coli detection and analysis of cells viability
    Ming Soon Cheng
    Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore, Singapore
    Environ Sci Technol 45:6453-9. 2011
    ....
  29. pmc Cocaine cues drive opposing context-dependent shifts in reward processing and emotional state
    Robert A Wheeler
    Department of Psychology, University of North Carolina, Chapel Hill, USA
    Biol Psychiatry 69:1067-74. 2011
    ..To test this, we examined dopamine release when cues signaled delayed cocaine delivery versus imminent cocaine self-administration...
  30. doi Electrochemistry and biosensing of glucose oxidase based on mesoporous carbons with different spatially ordered dimensions
    Chunping You
    Department of Chemistry and Institutes of Biomedical Sciences and Novel Materials, Fudan University, Shanghai 200433, PR China
    Talanta 78:705-10. 2009
    A strategy of protein entrapment within mesoporous carbon matrices is demonstrated to probe the electrochemistry of glucose oxidase...
  31. ncbi Membrane-based electrochemical nanobiosensor for the detection of virus
    Binh T T Nguyen
    Department of Chemistry, Faculty of Science, Yong Loo Lin School of Medicine, 3 Science Drive 3, National University of Singapore, Singapore 117543
    Anal Chem 81:7226-34. 2009
    ....
  32. ncbi Comparison between electrochemistry/mass spectrometry and cytochrome P450 catalyzed oxidation reactions
    Ulrik Jurva
    Centre for Pharmacy, University of Groningen, The Netherlands
    Rapid Commun Mass Spectrom 17:800-10. 2003
    The extent to which electrochemistry on-line with electrospray mass spectrometry can be used to mimic cytochrome P450 catalyzed oxidations has been investigated...
  33. doi Layer-by-Layer self-assembled acetylcholinesterase/PAMAM-Au on CNTs modified electrode for sensing pesticides
    Yunhe Qu
    Department of Chemistry, East China Normal University, Shanghai, PR China
    Bioelectrochemistry 77:139-44. 2010
    ..8x10(-9)M to 0.9x10(-7)M was exhibited with a detection limit of 4.0x10(-9)M. The biosensor showed high sensitivity, good stability and reproducibility with promising application...
  34. pmc Fast DNA sequencing via transverse electronic transport
    Johan Lagerqvist
    Department of Physics, University of California, San Diego, La Jolla, California 92093 0319, USA
    Nano Lett 6:779-82. 2006
    ..The practical implementation of our approach would represent a substantial advancement in our ability to study, predict, and cure diseases from the perspective of the genetic makeup of each individual...
  35. ncbi Action of antimicrobial peptides: two-state model
    H W Huang
    Department of Physics, Rice University, Houston, Texas 77251, USA
    Biochemistry 39:8347-52. 2000
    ....
  36. doi Direct electrochemistry of horseradish peroxidase immobilized on a monolayer modified nanowire array electrode
    Ju Xu
    Tyndall National Institute, University College Cork, Cork, Ireland
    Biosens Bioelectron 25:1313-8. 2010
    ..The ordered 3D gold nanowire array with high conductivity, excellent electron transfer capability and good biocompatibility proved promising for fabricating sensitive, selective, stable and mediator-free enzymatic biosensors...
  37. doi Glutaraldehyde activated eggshell membrane for immobilization of tyrosinase from Amorphophallus companulatus: application in construction of electrochemical biosensor for dopamine
    Sanket Tembe
    Department of Chemistry, University of Pune, Ganeshkhind, Pune 411007, India
    Anal Chim Acta 612:212-7. 2008
    ..19 V versus Ag/AgCl (3M KCl). Linearity was observed within the range of 50-250 microM with a detection limit of 25 microM...
  38. ncbi Label- and marker-free gene detection based on hybridization-induced conformational flexibility changes in a ferrocene-PNA conjugate probe
    Hiroshi Aoki
    National Institute of Advanced Industrial Science and Technology AIST, 16 1 Onogawa, Tsukuba, Ibaraki 305 8569, Japan
    Analyst 132:784-91. 2007
    ..Moreover, the sensor electrode was able repeatedly to detect the target DNA by the process of regeneration and could discriminate a mismatched DNA...
  39. ncbi Surface engineering of electrospun polyethylene terephthalate (PET) nanofibers towards development of a new material for blood vessel engineering
    Zuwei Ma
    Nanoscience and Nanotechnology Initiative, National University of Singapore, 9 Engineering Drive 1, Singapore 117576, Singapore
    Biomaterials 26:2527-36. 2005
    ..The gelatin grafting method can obviously improve the spreading and proliferation of the ECs on the PET NFM, and moreover, can preserve the EC's phenotype...
  40. ncbi Photoelectric properties of a detector based on dried bacteriorhodopsin film
    Wei Wei Wang
    Department of Mechanical and Materials Engineering, Faculty of Engineering, The University of Western Ontario, London, Ontario, Canada N6A 5B9
    Biosens Bioelectron 21:1309-19. 2006
    ..Experimental observations and a predictive model both support the notion that dried bR film can be used in simple highly sensitive photo-detector designs...
  41. ncbi Protein capture in silica nanotube membrane 3-D microwell arrays
    Myungchan Kang
    Department of Chemistry and Center for Research at the Bio Nano Interface, University of Florida, Gainesville, Florida 32611 7200, USA
    Anal Chem 77:6243-9. 2005
    ..The Ag surrounding the microwells shows very low background fluorescence, thus improving the signal-background ratio obtained from these arrays...
  42. doi New directions in medical biosensors employing poly(3,4-ethylenedioxy thiophene) derivative-based electrodes
    Noemi Rozlosnik
    Department of Micro and Nanotechnology, Technical University of Denmark, Ørsteds Plads, Bygning 345e, DK 2800, Kgs Lyngby, Denmark
    Anal Bioanal Chem 395:637-45. 2009
    ..This review paper summarizes newly developed methods associated with the application of PEDOT to diagnostic sensing...
  43. ncbi In vitro degradation and release profiles for electrospun polymeric fibers containing paracetanol
    Hongsen Peng
    Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, PR China
    Colloids Surf B Biointerfaces 66:206-12. 2008
    ..The result showed that the drug burst release behaviour was mainly related with the drug-polymer compatibility and the followed sustained release phase depended on polymer degradation...
  44. doi Applications of ionic liquids in electrochemical sensors
    Di Wei
    Process Chemistry Centre, c o Laboratory of Analytical Chemistry, Abo Akademi University, Biskopsgatan 8, FI 20500 Turku Abo, Finland
    Anal Chim Acta 607:126-35. 2008
    ..Besides a brief discussion of the properties of ILs and their general applications based on these properties, this review focuses on the application of ILs in electroanalytical sensors...
  45. doi Electrochemical interrogations of the Mtr cytochromes from Shewanella: opening a potential window
    Mackenzie Firer-Sherwood
    Department of Chemistry, Boston University, 590 Commonwealth Ave, Boston, MA 02215, USA
    J Biol Inorg Chem 13:849-54. 2008
    ..These data are taken together to suggest a model of electron transport where a wide window of potential allows for charge transfer from the cellular interior to the exterior to support bioenergetics...
  46. ncbi Trace analysis of an oligonucleotide with a specific sequence using PNA-based ion-channel sensors
    Hiroshi Aoki
    Department of Chemistry, School of Science, The University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Analyst 128:681-5. 2003
    ..Using a 13-mer PNA probe for this sensing mode, we achieved the detection of the oligonucleotide at a femtomolar (approximately 10-15 M) level, improved by five orders of magnitude than the previously used 10-mer PNA probe...
  47. ncbi Hydrothermally shrunk alumina nanopores and their application to DNA sensing
    Pavel Takmakov
    Department of Chemistry and Biochemistry, New Mexico State University, Las Cruces, New Mexico 88003, USA
    Analyst 131:1248-53. 2006
    ..Hybridization of target DNA with a complementary ssDNA covalently immobilized inside the nanopores causes an increase in impedance by more than 50% while a noncomplementary ssDNA has no measurable effect...
  48. ncbi An efficient bicomponent TiO2/SnO2 nanofiber photocatalyst fabricated by electrospinning with a side-by-side dual spinneret method
    Zhaoyang Liu
    School of Civil and Environmental Engineering, Nanyang Technological University, Singapore
    Nano Lett 7:1081-5. 2007
    ..We believe that this versatile approach can be extended to fabricate other novel high-efficiency bicomponent photocatalysts...
  49. doi Enhanced electrochemiluminescence of CdSe quantum dots composited with CNTs and PDDA for sensitive immunoassay
    Guifen Jie
    Key Laboratory of Analytical Chemistry for Life Science Ministry of Education of China, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, PR China
    Biosens Bioelectron 24:3352-8. 2009
    ..This work opened the new avenues for applying QDs ECL in highly sensitive bioassays...
  50. ncbi Direct electrochemistry of immobilized human cytochrome P450 2E1
    Andrea Fantuzzi
    Department of Biological Sciences, Imperial College, London, UK
    J Am Chem Soc 126:5040-1. 2004
    ..The turnover of the active enzyme was measured with the P450 2E1 specific substrate p-nitrophenol, resulting in a KM of 130 +/- 3 muM and the formation of 2.2 muM of the p-nitrocatechol product upon application of a -300 mV bias...
  51. pmc Functional electrospun nanofibrous scaffolds for biomedical applications
    Dehai Liang
    Departments of Chemistry and of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11794 3400, USA
    Adv Drug Deliv Rev 59:1392-412. 2007
    ..In this article, we review the materials, techniques and post modification methods to functionalize electrospun nanofibrous scaffolds suitable for biomedical applications...
  52. doi Nanogap detector inside nanofluidic channel for fast real-time label-free DNA analysis
    Xiaogan Liang
    NanoStructure Laboratory, Department of Electrical Engineering, Princeton University, Princeton, New Jersey 08544, USA
    Nano Lett 8:1472-6. 2008
    ..We have observed electrical signals caused by 1.1 kilobase-pair (kbp) double-stranded (ds)-DNA passing through the gap in the nanogap detectors with a gap equal to or less than 13 nm...
  53. ncbi The flavoprotein subcomplex of complex I (NADH:ubiquinone oxidoreductase) from bovine heart mitochondria: insights into the mechanisms of NADH oxidation and NAD+ reduction from protein film voltammetry
    Chérise D Barker
    Medical Research Council Dunn Human Nutrition Unit, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 2XY, UK
    Biochemistry 46:3454-64. 2007
    ..Two possible models reproduce the observed catalytic waveshapes: one describing an effect from reducing the proximal [2Fe-2S] cluster and the other the enhanced catalytic ability of the semiflavin state...
  54. ncbi Improved selectivity and stability of glucose biosensor based on in situ electropolymerized polyaniline-polyacrylonitrile composite film
    Huaiguo Xue
    School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China
    Biosens Bioelectron 20:2330-4. 2005
    ..Blood glucose determinations agreed well with standard hospital laboratory analysis. The construction and operational parameters of the biosensor were also optimized...
  55. pmc Patterning of polymer nanofiber meshes by electrospinning for biomedical applications
    Nuno M Neves
    Department of Polymer Engineering, University of Minho, Campus de Azurem, 4800 058 Guimaraes, Portugal
    Int J Nanomedicine 2:433-48. 2007
    ..The present study will evaluate cell adhesion sensitivity to the patterns generated and the effect of those patterns on the tensile properties of the fiber meshes...
  56. ncbi Electrocatalytic oxidation of dopamine at an ionic liquid modified carbon paste electrode and its analytical application
    Wei Sun
    College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, China
    Anal Bioanal Chem 389:1283-91. 2007
    ..The IL-CPE fabricated was sensitive, selective and showed good ability to distinguish the coexisting ascorbic acid and uric acid...
  57. ncbi A portable potentiostat for the bilirubin-specific sensor prepared from molecular imprinting
    Chun Yueh Huang
    Institute of Communication Engineering, National University of Tainan, Taiwan, ROC
    Biosens Bioelectron 22:1694-9. 2007
    ..The self-assembled potentiostat thus demonstrated its ability in precise detection of bilirubin from an electrode layered with the imprinted polymer film...
  58. ncbi Microelectrodes for the measurement of catecholamines in biological systems
    P S Cahill
    Department of Chemistry, University of North Carolina, Chapel Hill 27599 3290, USA
    Anal Chem 68:3180-6. 1996
    ..Also, high-pass filtering discriminated against ascorbic acid, DOPAC, and acidic pH changes, three common interferences in vivo...
  59. doi Voltammetric studies on the HIV-1 inhibitory drug Efavirenz: the interaction between dsDNA and drug using electrochemical DNA biosensor and adsorptive stripping voltammetric determination on disposable pencil graphite electrode
    Burcu Dogan-Topal
    Ankara University, Faculty of Pharmacy, Department of Analytical Chemistry, 06100, Tandogan, Ankara, Turkey
    Biosens Bioelectron 24:2358-64. 2009
    ..Under these conditions, the current showed a linear dependence with concentration in the range between 0.018 and 2.56 ppm. Both determination methods were fully validated and applied for the analysis of EFV pharmaceutical dosage form...
  60. ncbi Intraperitoneal zinc administration increases extracellular zinc in the rat prefrontal cortex
    W Opoka
    Laboratory of Trace Elements Neurobiology, Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    J Physiol Pharmacol 59:477-87. 2008
    ..The results indicate zinc-induced fast brain penetration and may explain its rapid pharmacological effects...
  61. ncbi Cyclic voltammetry and voltabsorptometry studies of redox proteins immobilised on nanocrystalline tin dioxide electrodes
    Yeni Astuti
    Department of Chemistry, Imperial College London, Exhibition Road, South Kensington, London SW7 2AZ, UK
    Bioelectrochemistry 63:55-9. 2004
    ..We demonstrate that cyclic voltabsorptometry allows the unambiguous and background free observation of redox reactions for both systems studied...
  62. doi Towards biosensors based on conducting polymer nanowires
    Sagar B Tolani
    Department of Chemistry, Missouri State University, Springfield, MO 65897, USA
    Anal Bioanal Chem 393:1225-31. 2009
    ..Therefore, the technology has the potential to positively impact broad analytical applications in the biomedical, environmental and other sectors...
  63. ncbi A tris(2,2'-bipyridyl)cobalt(III)-bovine serum albumin composite membrane for biosensors
    Ying Zhuo
    Key Laboratory of Analytical Chemistry Chongqing, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, PR China
    Biomaterials 27:5420-9. 2006
    ..50-80.00 ng/mL with a limit of detection of 0.14 ng/mL, as well as good stability and long-term life...
  64. ncbi An electrical probe of protein-DNA interactions on DNA-modified surfaces
    Elizabeth M Boon
    Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA
    Nat Biotechnol 20:282-6. 2002
    ..Importantly, the kinetics of restriction by R.PvuII of its nonmethylated target is also easily monitored electrochemically. This approach should be generally applicable to assaying protein--DNA interactions and reactions on surfaces...
  65. ncbi Electrochemical treatment of tumours
    E Nilsson
    Department of Chemical Engineering and Technology, Applied Electrochemistry, Royal Institute of Technology KTH, Stockholm, Sweden
    Bioelectrochemistry 51:1-11. 2000
    ..In addition, we discuss our view of different important parameters that have to be accounted for, if clinical trials are to be initiated outside of China...
  66. ncbi Mathematical modelling of physicochemical reactions and transport processes occurring around a platinum cathode during the electrochemical treatment of tumours
    E Nilsson
    Department of Chemical Engineering and Technology, Applied Electrochemistry, Royal Institute of Technology KTH, Stockholm, Sweden
    Bioelectrochemistry 53:213-24. 2001
    ..In addition, the simulations indicate that the model could be of use in predicting the size of a lesion produced by EChT...
  67. ncbi Ion transport in tumors under electrochemical treatment: in vivo, in vitro and in silico modeling
    L Colombo
    Depto de Inmunobiología, Inst de Oncología Angel H Roffo, Universidad de Buenos Aires, C1417DTB Buenos Aires, Argentina
    Bioelectrochemistry 71:223-32. 2007
    ..These results could have significant implications in EChT optimal operative conditions and dose planning, in particular, in the way in which the evolving EChT pH region covers the active cancer cells spherical casket...
  68. ncbi Electrospun chitosan-based nanofibers and their cellular compatibility
    Narayan Bhattarai
    Department of Materials Science and Engineering, University of Washington, Seattle, WA 98195 2120, USA
    Biomaterials 26:6176-84. 2005
    ..This nanofibrous matrix is of particular interest in tissue engineering for controlled drug release and tissue remodeling...
  69. pmc Preferential enhancement of dopamine transmission within the nucleus accumbens shell by cocaine is attributable to a direct increase in phasic dopamine release events
    Brandon J Aragona
    Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3290, USA
    J Neurosci 28:8821-31. 2008
    ..Together, these results demonstrate that cocaine administration results in a temporally and regionally specific increase in phasic dopamine release that is significantly regulated by dopamine autoreceptors...
  70. pmc Electrochemical sensing in paper-based microfluidic devices
    Zhihong Nie
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
    Lab Chip 10:477-83. 2010
    ..g., heavy-metal ions and glucose) in aqueous solutions. This low-cost analytical device should be useful for applications in public health, environmental monitoring, and the developing world...
  71. doi [Os(IV)Cl(5)(Hazole)](-) complexes: synthesis, structure, spectroscopic properties, and antiproliferative activity
    Gabriel E Büchel
    University of Vienna, Institute of Inorganic Chemistry, Austria
    Inorg Chem 48:10737-47. 2009
    ..Replacement of azolium cations by sodium had significant effects; cytotoxicity increased in the case of the pyrazole system from 3 (A549) to the 5.5-fold (CH1)...
  72. ncbi Electronic structures of metal sites in proteins and models: contributions to function in blue copper proteins
    Edward I Solomon
    Department of Chemistry, Stanford University, Stanford, California 94305, USA
    Chem Rev 104:419-58. 2004
  73. doi Electrochemical and piezoelectric DNA biosensors for hybridisation detection
    Fausto Lucarelli
    Department of Chemistry, University of Florence, 50019 Sesto Fiorentino, Florence, Italy
    Anal Chim Acta 609:139-59. 2008
    ..Special emphasis will be finally given to those protocols that, being implemented into an array format, are already penetrating the molecular diagnostics market...
  74. doi Electrode modified with a composite film of ZnO nanorods and Ag nanoparticles as a sensor for hydrogen peroxide
    Chia Yu Lin
    Department of Chemical Engineering, National Taiwan University, Taipei 10617, Taiwan
    Talanta 82:340-7. 2010
    ..Sensing properties of the modified electrode were studied both by CV and amperometric analysis...
  75. ncbi Biomolecule immobilization on electrode surfaces by entrapment or attachment to electrochemically polymerized films. A review
    S Cosnier
    Laboratoire d Electrochimie Organique et de Photochimie Redox, UMR CNRS 5630, Universite Joseph Fourier Grenoble 1, France
    Biosens Bioelectron 14:443-56. 1999
    ..Moreover, the attachment of biomolecules to biotinylated polymers through affinity interactions based on avidin-biotin bridge is presented...
  76. ncbi Analysis of exocytotic events recorded by amperometry
    Eugene V Mosharov
    Department of Neurology, Black Building 305, 650 W 168th Street, Columbia University, New York, New York 10032, USA
    Nat Methods 2:651-8. 2005
    ..The purpose of this review is to provide practical guidelines for performing amperometric recordings of exocytotic activity and interpreting the results based on shape characteristics of individual release events...
  77. ncbi Dopamine release is heterogeneous within microenvironments of the rat nucleus accumbens
    R Mark Wightman
    Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3290, USA
    Eur J Neurosci 26:2046-54. 2007
    ..These findings reveal an unanticipated spatial and temporal heterogeneity of dopamine transmission within the NAc that may depend upon the firing of specific subpopulations of dopamine neurons...
  78. ncbi Sensor arrays for liquid sensing--electronic tongue systems
    Patrycja Ciosek
    Department of Analytical Chemistry, Warsaw University of Technology, Noakowskiego 3, 00 664 Warsaw, Poland
    Analyst 132:963-78. 2007
    ..All of these topics are summarized in this review. Moreover, additional problems are considered: miniaturization of electronic tongues and hybrid systems for liquid sensing...
  79. pmc Biofuel cells select for microbial consortia that self-mediate electron transfer
    Korneel Rabaey
    Faculty of Agricultural and Applied Biological Sciences, Laboratory of Microbial Ecology and Technology, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    Appl Environ Microbiol 70:5373-82. 2004
    ....
  80. pmc The Na channel voltage sensor associated with inactivation is localized to the external charged residues of domain IV, S4
    M F Sheets
    The Nora Eccles Harrison Cardiovascular Research and Training Institute and Department of Internal Medicine, University of Utah, Salt Lake City, Utah 84112, USA
    Biophys J 77:747-57. 1999
    ....
  81. pmc Microfabricated microbial fuel cell arrays reveal electrochemically active microbes
    Huijie Hou
    Department of Electrical and Computer Engineering, Texas A and M University, College Station, TX, USA
    PLoS ONE 4:e6570. 2009
    ..MR-7, and displayed 2.3-fold higher power output than the S. oneidensis MR-1 reference strain. Therefore, the utility of the MFC array was demonstrated...
  82. doi Cell-based detection of electrochemical oxidative stress by a fluorescent tryptophan intermediate
    Nadav Ben-Dov
    Department of Physiology and Pharmacology, Faculty of Medicine, Tel Aviv University, 69978 Tel Aviv, Israel
    Bioelectrochemistry 84:11-7. 2012
    ..The analysis of the intracellularly stabilized tryptophan intermediate by flow cytometry can be used for measuring external oxidation stress without the disturbance of intracellular anti-oxidative capacity...
  83. ncbi Battery technologies for large-scale stationary energy storage
    Grigorii L Soloveichik
    General Electric Global Research, Niskayuna, NY 12309, USA
    Annu Rev Chem Biomol Eng 2:503-27. 2011
    ..Regenerative fuel cells and lithium metal batteries with high energy density require further research to become practical...
  84. doi Electrochemistry and bioactivity relationship of 6-substituted-4H-pyrido[4,3,2-kl]acridin-4-one antitumor drug candidates
    Laurent Bouffier
    Univ Bordeaux, ISM, CNRS UMR 5255, F 33400, Talence, France
    Bioelectrochemistry 88:103-9. 2012
    ..But aqueous solution electrochemistry is definitely the most bio-relevant because the redox mechanism of quinone or iminoquinone reduction directly ..
  85. ncbi Disposable electrochemical printed gold chips for the analysis of acetylcholinesterase inhibition
    Vladimir Dounin
    Department of Physical and Environmental Sciences, University of Toronto at Scarborough, 1265 Military Trail, Toronto, ON, M1C 1A4, Canada
    Anal Chim Acta 669:63-7. 2010
    ....
  86. doi Electrochemistry of conductive polymers. 45. Nanoscale conductivity of PEDOT and PEDOT:PSS composite films studied by current-sensing AFM
    Hyo Joong Lee
    Department of Chemistry, Pohang University of Science and Technology POSTECH, Pohang, 790 784, Korea, ROK
    J Phys Chem B 114:2660-6. 2010
    ..The conductivity of all these films was shown to be significantly enhanced by the electrochemical doping process...
  87. ncbi Electrospinning of chitin nanofibers: degradation behavior and cellular response to normal human keratinocytes and fibroblasts
    Hyung Kil Noh
    Department of Oral Biochemistry and Craniomaxillofacial Reconstructive Science, Dental Research Institute, BK21 HLS, and IBEC, Seoul National University College of Dentistry, Seoul 110 749, South Korea
    Biomaterials 27:3934-44. 2006
    ..This property of Chi-N might be particularly useful for wound healing and regeneration of oral mucosa and skin...
  88. doi CVD graphene electrochemistry: biologically relevant molecules
    Dale A C Brownson
    Faculty of Science and Engineering, School of Science and the Environment, Division of Chemistry and Environmental Science, Manchester Metropolitan University, Chester Street, Manchester M1 5GD, Lancs, UK
    Phys Chem Chem Phys 13:20284-8. 2011
    ..including the presence of 'graphitic islands' on the surface of the CVD-graphene which dominate its electrochemistry. In the systems studied within, it appears at best, CVD-graphene acts akin to that of an edge plane pyrolytic ..
  89. ncbi Hydrogen peroxide biosensor based on the direct electrochemistry of myoglobin immobilized on silver nanoparticles doped carbon nanotubes film
    Chuan Yin Liu
    College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, PR China
    Biosens Bioelectron 24:2149-54. 2009
    A novel H(2)O(2) biosensor has been fabricated based on the direct electrochemistry and electrocatalysis of myoglobin (Mb) immobilized on silver nanoparticles doped carbon nanotubes film with hybrid sol-gel techniques...
  90. doi Simultaneous determination of L-ascorbic acid, dopamine and uric acid with gold nanoparticles-β-cyclodextrin-graphene-modified electrode by square wave voltammetry
    Xianqing Tian
    College of Chemistry, Sichuan University, 29 Wangjiang Road, Chengdu 610064, PR China
    Talanta 93:79-85. 2012
    ..Our work provides a simple, convenient and green route to synthesize AuNPs on Gra which is potentially useful in electroanalysis...
  91. doi Production of a reactive metabolite of troglitazone by electrochemical oxidation performed in nonaqueous medium
    Kayoko Tahara
    Division of Clinical Physiology and Therapeutics, Faculty of Pharmacy, Keio University, 1 5 30 Shibakoen, Minato ku, Tokyo 105 8512, Japan
    J Pharm Biomed Anal 50:1030-6. 2009
    ..Thus, the method of electrochemical oxidation in nonaqueous medium is considered to be useful to prepare and predict reactive metabolites of drugs that are unstable in aqueous medium or in vivo...
  92. ncbi Quantification of electron transfer rates to a solid phase electron acceptor through the stages of biofilm formation from single cells to multicellular communities
    Jeffrey S McLean
    The J Craig Venter Institute, San Diego, CA, USA
    Environ Sci Technol 44:2721-7. 2010
    ..These data suggest a link between the ability of a surface to accept electrons and biofilm structure development...
  93. doi Improving polymer nanofiber quality using a modified co-axial electrospinning process
    Deng Guang Yu
    College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, China
    Macromol Rapid Commun 32:744-50. 2011
    ..High quality PVP nanofibers of average diameter 130 ±10 nm with homogeneous structures and smooth surfaces are created using a solvent mixture of acetone, ethanol and DMAc in the ratio of 3:1:1(v/v/v)...
  94. ncbi Specific oxygen-containing functional groups on the carbon surface underlie an enhanced sensitivity to dopamine at electrochemically pretreated carbon fiber microelectrodes
    James G Roberts
    Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695, USA
    Langmuir 26:9116-22. 2010
    ....
  95. doi Electrochemical charge of silica surfaces at high ionic strength in narrow channels
    Moran Wang
    Computational Earth Sciences Group EES 16, Earth and Environmental Sciences Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    J Colloid Interface Sci 343:381-6. 2010
    ..The charge regulation caused by the double-layer overlap in narrow channels will reduce the surface charge density but increase the zeta potential on silica surfaces...
  96. doi Direct electrochemistry and electrocatalysis of hemoglobin on gold nanoparticle decorated carbon ionic liquid electrode
    Wei Sun
    Key Laboratory of Eco Chemical Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, People s Republic of China
    Talanta 80:2177-81. 2010
    ..2 to 18.0 mmol/L with the detection limit as 0.16 mmol/L (S/N=3). The proposed electrode showed good stability and reproducibility, and it had the potential application as a new third-generation electrochemical biosensor...
  97. ncbi Electrochemistry in the mimicry of oxidative drug metabolism by cytochrome P450s
    Eslam Nouri-Nigjeh
    Analytical Biochemistry and Mass Spectrometry Core Facility, Department of Pharmacy, University of Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Curr Drug Metab 12:359-71. 2011
    ..reaction is based on O-O bond activation in hydrogen peroxide and oxidation by hydroxyl radicals, wherein electrochemistry is used for the reduction of molecular oxygen to hydrogen peroxide, as well as the reduction of Fe(3+) to Fe(..
  98. doi Development of biosensors containing laccase and imidazolium bis(trifluoromethylsulfonyl)imide ionic liquid for the determination of rutin
    Ana Cristina Franzoi
    Departamento de Quimica, Laboratório de Biossensores, Universidade Federal de Santa Catarina, 88040 970 Florianopolis, SC, Brazil
    Anal Chim Acta 639:90-5. 2009
    ..The studies on rutin recovery from these samples gave values of 96.9-104.6%...
  99. ncbi Membrane-bound hydrogenase I from the hyperthermophilic bacterium Aquifex aeolicus: enzyme activation, redox intermediates and oxygen tolerance
    Maria Eirini Pandelia
    Max Planck Institut fur Bioanorganische Chemie, Stiftstrasse 34 36, D45470, Mulheim a d Ruhr, Germany
    J Am Chem Soc 132:6991-7004. 2010
    ..Protein film electrochemistry is employed here to portray the interaction of Hase I with molecular oxygen and obtain an overall picture of ..
  100. doi Application of mass fabricated silicon-based gold transducers for amperometric biosensors
    Robert Ziółkowski
    Faculty of Chemistry, Department of Microbioanalytics, Warsaw University of Technology, Noakowskiego 3, 00 664 Warsaw, Poland
    Bioelectrochemistry 80:31-7. 2010
    ..Obtained results are in full agreement with literature data. The compact size of silicone-based transducers allows to significantly reduce the required volume of tested solutions...
  101. doi Hierarchically structured one-dimensional TiO2 for protein immobilization, direct electrochemistry, and mediator-free glucose sensing
    Peng Si
    School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, Singapore 637457
    ACS Nano 5:7617-26. 2011
    ..The fabricated biosensor displayed good selectivity and long-term stability, indicating that the novel structured TiO(2) is a promising material for the immobilization of biomolecules and the fabrication of third-generation biosensors...

Research Grants73

  1. ELECTROANALYSIS OF NEUROTRANSMITTERS AND MODULATORS
    Robert Wightman; Fiscal Year: 2005
    DESCRIPTION: (Adapted from applicant's abstract) The goals of this research proposal are to develop and use electrochemistry-based probes to monitor neurotransmitters in intact brain tissue...
  2. ELECTROCHEMICAL DNA-BASED SENSORS
    JACQUELINE BARTON; Fiscal Year: 2009
    The overall objective of this renewal application is the development of DNA-mediated electrochemistry as a new technology for sensing DNA-binding proteins and nucleic acids...
  3. ELECTROCHEMICAL DNA-BASED SENSORS
    Jacqueline K Barton; Fiscal Year: 2010
    The overall objective of this renewal application is the development of DNA-mediated electrochemistry as a new technology for sensing DNA-binding proteins and nucleic acids...
  4. Low-Coordinate Synthetic Models for Nitrogenase Activity
    Patrick L Holland; Fiscal Year: 2010
    ..Crystallography, kinetic studies, electrochemistry, and reactivity will be used to elucidate the atomic-level detail of the elementary steps of small-molecule ..
  5. The Electrochemistry of Diheme Cytochrome c Peroxidases
    SEAN ELLIOTT; Fiscal Year: 2009
    ..Further, our study of triheme CCPs will elucidate the CCP machinery which is unique to pathogens such as Salmonella enterica and Yersinia pestis, providing new insights into their biochemical pathways. ..
  6. CATECHOLAMINES AND SEROTONIN IN BLOOD PRESSURE CONTROL
    Curt Freed; Fiscal Year: 1990
    ..With the new technique of in vivo electrochemistry, we have been able to follow the time course of catechol and 5-HIAA concentrations continuously during drug- ..
  7. NITRIC OXIDE INTERACTION WITH INSECT NITROPHORINS
    Frances Walker; Fiscal Year: 2005
    ..prolixus by preparing and studying the electrochemistry of mutants of charged residues near the heme, and to determine which residues could be modified to alter the ..
  8. NITRIC OXIDE INTERACTION WITH INSECT NITROPHORINS
    Frances Walker; Fiscal Year: 2006
    ..prolixus by preparing and studying the electrochemistry of mutants of charged residues near the heme, and to determine which residues could be modified to alter the ..
  9. NITRIC OXIDE INTERACTION WITH INSECT NITROPHORINS
    Frances Walker; Fiscal Year: 2004
    ..prolixus by preparing and studying the electrochemistry of mutants of charged residues near the heme, and to determine which residues could be modified to alter the ..
  10. NITRIC OXIDE INTERACTION WITH INSECT NITROPHORINS
    Frances Walker; Fiscal Year: 2003
    ..prolixus by preparing and studying the electrochemistry of mutants of charged residues near the heme, and to determine which residues could be modified to alter the ..
  11. The Role of Adenosine in Ketogenic Diet Therapy
    SUSAN A contact MASINO; Fiscal Year: 2010
    ..on synaptic transmission and neuronal excitability will be quantified using detailed electrophysiology and electrochemistry (Aim 2)...
  12. PROTEINS OF NORMAL AND CATARACTOUS LENSES
    FRANK GIBLIN; Fiscal Year: 1991
    ..Sensitive methods involving HPLC, electrochemistry and electron spin resonance (ESR) will be employed to measure lens and aqueous humor levels of reduced and ..
  13. PROTEINS OF NORMAL AND CATARACTOUS LENSES
    FRANK GIBLIN; Fiscal Year: 1992
    ..Sensitive methods involving HPLC, electrochemistry and electron spin resonance (ESR) will be employed to measure lens and aqueous humor levels of reduced and ..
  14. PROTEINS OF NORMAL AND CATARACTOUS LENSES
    FRANK GIBLIN; Fiscal Year: 1993
    ..Sensitive methods involving HPLC, electrochemistry and electron spin resonance (ESR) will be employed to measure lens and aqueous humor levels of reduced and ..
  15. The Electrochemistry of Diheme Cytochrome c Peroxidases
    SEAN ELLIOTT; Fiscal Year: 2009
    ..Further, our study of triheme CCPs will elucidate the CCP machinery which is unique to pathogens such as Salmonella enterica and Yersinia pestis, providing new insights into their biochemical pathways. ..
  16. The Electrochemistry of Diheme Cytochrome c Peroxidases
    SEAN ELLIOTT; Fiscal Year: 2007
    ..Further, our study of triheme CCPs will elucidate the CCP machinery which is unique to pathogens such as Salmonella enterica and Yersinia pestis, providing new insights into their biochemical pathways. ..
  17. The Electrochemistry of Diheme Cytochrome c Peroxidases
    SEAN ELLIOTT; Fiscal Year: 2006
    ..Further, our study of triheme CCPs will elucidate the CCP machinery which is unique to pathogens such as Salmonella enterica and Yersinia pestis, providing new insights into their biochemical pathways. ..
  18. The Electrochemistry of Diheme Cytochrome c Peroxidases
    Sean J Elliott; Fiscal Year: 2010
    ..Further, our study of triheme CCPs will elucidate the CCP machinery which is unique to pathogens such as Salmonella enterica and Yersinia pestis, providing new insights into their biochemical pathways. ..
  19. Portable Pesticide Monitor
    TONY RAGUCCI; Fiscal Year: 2007
    ..with backgrounds in sensor design and fabrication, enzyme characterization, software/hardware programming and electrochemistry, making this research project truly multidisciplinary, thereby providing the necessary expertise to make this ..
  20. Nitrogen Oxides and Heme
    GEORGE RICHTER ADDO; Fiscal Year: 2007
    ..liganded heme model compounds with NO ligands and characterize them by spectroscopy (IR, EPR, rR, UV-vis), electrochemistry, and crystallography...
  21. COORDINATION CHEMISTRY OF VANADIUM IN BIOLOGY SYSTEM
    CARL CARRANO; Fiscal Year: 1992
    ..will include UV-vis spectro-photometry, NMR (1H, 13C and 51V as appropriate), EPR, magnetic measurements, electrochemistry and, when appropriate, single crystal X-ray diffraction...
  22. Oxidative Stress and Glutamate Excitotoxicity on Aged Dopaminergic Neruons
    Heather A Boger; Fiscal Year: 2010
    ..Year 1-2) of the award from a team of collaborating mentors that include training in molecular biology, electrochemistry, production of nanoparticles (microspheres), and statistics...
  23. Oxidative Stress and Glutamate Excitotoxicity on Aged Dopaminergic Neruons
    Heather Boger; Fiscal Year: 2009
    ..Year 1-2) of the award from a team of collaborating mentors that include training in molecular biology, electrochemistry, production of nanoparticles (microspheres), and statistics...
  24. Oxidative Stress and Glutamate Excitotoxicity on Aged Dopaminergic Neruons
    Heather A Boger; Fiscal Year: 2011
    ..Year 1-2) of the award from a team of collaborating mentors that include training in molecular biology, electrochemistry, production of nanoparticles (microspheres), and statistics...
  25. IDENTIFICATION OF ACOUSTICO-LATERALIS TRANSMITTERS
    DENNIS DRESCHER; Fiscal Year: 2000
    ..Methods include: 1) high- resolution, high-performance liquid chromatography (HPLC) with detection by electrochemistry, fluorescence, radioactivity, and radioimmunoassay, 2) analysis of tissue content, and depolarization-induced ..
  26. IDENTIFICATION OF ACOUSTICO-LATERALIS TRANSMITTERS
    DENNIS DRESCHER; Fiscal Year: 2001
    ..Methods include: 1) high- resolution, high-performance liquid chromatography (HPLC) with detection by electrochemistry, fluorescence, radioactivity, and radioimmunoassay, 2) analysis of tissue content, and depolarization-induced ..
  27. IDENTIFICATION OF ACOUSTICO-LATERALIS TRANSMITTERS
    DENNIS DRESCHER; Fiscal Year: 1999
    ..Methods include: 1) high- resolution, high-performance liquid chromatography (HPLC) with detection by electrochemistry, fluorescence, radioactivity, and radioimmunoassay, 2) analysis of tissue content, and depolarization-induced ..
  28. MARIJUANA & DOPAMINE/ENKEPHALIN BRAIN REWARD SYSTEMS
    ELIOT GARDNER; Fiscal Year: 1992
    ..on DA release, in forebrain DA loci supporting direct brain reward, as measured by both in vivo voltammetric electrochemistry and in vivo intracranial microdialysis; and (3) extend our studies of the interaction of delta9-THC and ..
  29. MARIJUANA & DOPAMINE/ENKEPHALIN BRAIN REWARD SYSTEMS
    ELIOT GARDNER; Fiscal Year: 1990
    ..on DA release, in forebrain DA loci supporting direct brain reward, as measured by both in vivo voltammetric electrochemistry and in vivo intracranial microdialysis; and (3) extend our studies of the interaction of delta9-THC and ..
  30. IDENTIFICATION OF ACOUSTICO-LATERALIS TRANSMITTERS
    DENNIS DRESCHER; Fiscal Year: 2002
    ..Methods include: 1) high- resolution, high-performance liquid chromatography (HPLC) with detection by electrochemistry, fluorescence, radioactivity, and radioimmunoassay, 2) analysis of tissue content, and depolarization-induced ..
  31. NITRIC OXIDE INTERACTION WITH INSECT NITROPHORINS
    Frances Walker; Fiscal Year: 2000
    ..Specific aims include the investigation of the electrochemistry of NP2 and NP3, for comparison to NP1 and NP4, in the absence and presence of NO, and of selected site-..
  32. NITRIC OXIDE INTERACTION WITH INSECT NITROPHORINS
    Frances Walker; Fiscal Year: 2002
    ..Specific aims include the investigation of the electrochemistry of NP2 and NP3, for comparison to NP1 and NP4, in the absence and presence of NO, and of selected site-..
  33. NITRIC OXIDE INTERACTION WITH INSECT NITROPHORINS
    Frances Walker; Fiscal Year: 1999
    ..Specific aims include the investigation of the electrochemistry of NP2 and NP3, for comparison to NP1 and NP4, in the absence and presence of NO, and of selected site-..
  34. NITRIC OXIDE INTERACTION WITH INSECT NITROPHORINS
    Frances Walker; Fiscal Year: 2001
    ..Specific aims include the investigation of the electrochemistry of NP2 and NP3, for comparison to NP1 and NP4, in the absence and presence of NO, and of selected site-..
  35. Improved Batteries for Implantable Cardiac Defibrillators
    Kenneth J Takeuchi; Fiscal Year: 2012
    ..The proposed activity involves the synthesis, characterization and electrochemistry of a new family of materials, MM'POs...
  36. Improved Batteries for Implantable Cardiac Defibrillators
    Kenneth J Takeuchi; Fiscal Year: 2010
    ..The proposed activity involves the synthesis, characterization and electrochemistry of a new family of materials, MM'POs...
  37. Improved Batteries for Implantable Cardiac Defibrillators
    ESTHER TAKEUCHI; Fiscal Year: 2009
    ..The proposed activity involves the synthesis, characterization and electrochemistry of a new family of materials, MM'POs...
  38. Synthetic Models and Spectroscopy of Nonheme Diiron Enzymes
    Lawrence Que; Fiscal Year: 2009
    ..by a variety of techniques such as NMR, EPR, UV-vis-NIR, Raman, Mossbauer, electrospray mass spectrometry, electrochemistry, and EXAFS...
  39. Synthetic Models and Spectroscopy of Nonheme Diiron Enzymes
    Lawrence Que; Fiscal Year: 2010
    ..by a variety of techniques such as NMR, EPR, UV-vis-NIR, Raman, Mossbauer, electrospray mass spectrometry, electrochemistry, and EXAFS...
  40. Synthetic Models and Spectroscopy of Nonheme Diiron Enzymes
    Lawrence Que; Fiscal Year: 2007
    ..by a variety of techniques such as NMR, EPR, UV-vis-NIR, Raman, Mossbauer, electrospray mass spectrometry, electrochemistry, and EXAFS...
  41. ELECTRON TRANSLOCATION IN BIOLOGICAL ENERGY CONVERSION
    P Dutton; Fiscal Year: 1990
    ..Quinonoid compounds will be studied from the standpoint of their structure, their substituents, electrochemistry, and hydrophobic properties...
  42. MODELS OF NITRATE REDUCTASES AND RELATED ENZYMES
    Partha Basu; Fiscal Year: 2000
    ..These compounds will be analyzed with a combination of techniques such as electrochemistry, optical spectroscopy, and magnetic resonance spectroscopy. The specific aims of the proposal are: 1...
  43. ELECTROANALYSIS OF NEUROTRANSMITTERS AND MODULATORS
    ROBERT MARK WIGHTMAN; Fiscal Year: 2010
    ..The research plan is based upon our prior development of an electrochemistry-based method to monitor dopamine in behaving animals...
  44. AGE RELATED DECLINES IN MOVEMENT FUNCTIONS IN RHESUS MONKEYS
    Greg Gerhardt; Fiscal Year: 2001
    ..In addition, studies of DA uptake will be performed using in vivo electrochemistry in the vehicle and GDNF-treated animals...
  45. AGE RELATED DECLINES IN MOVEMENT FUNCTIONS IN RHESUS MONKEYS
    Greg Gerhardt; Fiscal Year: 1999
    ..In addition, studies of DA uptake will be performed using in vivo electrochemistry in the vehicle and GDNF-treated animals...
  46. AGE RELATED DECLINES IN MOVEMENT FUNCTIONS IN RHESUS MONKEYS
    Greg Gerhardt; Fiscal Year: 2000
    ..In addition, studies of DA uptake will be performed using in vivo electrochemistry in the vehicle and GDNF-treated animals...
  47. COORDINATION CHEMISTRY OF MICROBIAL IRON TRANSPORT
    Kenneth Raymond; Fiscal Year: 1993
    ..Fundamental data on solution thermodynamics, kinetics, and electrochemistry are determined to examine iron release mechanisms...
  48. Synthetic Models and Spectroscopy of Nonheme Diiron Enzymes
    Lawrence Que; Fiscal Year: 2009
    ..by a variety of techniques such as NMR, EPR, UV-vis-NIR, Raman, M"ssbauer, electrospray mass spectrometry, electrochemistry, and EXAFS...
  49. COORDINATION CHEMISTRY OF MICROBIAL IRON TRANSPORT
    Kenneth Raymond; Fiscal Year: 1992
    ..Fundamental data on solution thermodynamics, kinetics, and electrochemistry are determined to examine iron release mechanisms...
  50. COORDINATION CHEMISTRY OF MICROBIAL IRON TRANSPORT
    Kenneth Raymond; Fiscal Year: 1991
    ..Fundamental data on solution thermodynamics, kinetics, and electrochemistry are determined to examine iron release mechanisms...
  51. Electrochemistry /Spectroscopy of Protein/Nanomaterial-B
    Hiroyasu Tachikawa; Fiscal Year: 2006
    ..grant period we have successfully measured the formal potentials of myoglobin and cytochromes by direct electrochemistry at electrodes modified with those substrates...
  52. ELECTROCHEMICAL DIALYSATE REGENERATION
    SIDNEY WOLFSON; Fiscal Year: 1992
    ..The specific aims will be accomplished through a laboratory investigation using electrochemistry, wet chemistry, and dialysis apparatus...
  53. Mechanism of Action of Deep Brain Stimulation
    KENDALL LEE; Fiscal Year: 2009
    ..This program will promote the command of electrophysiology, electrochemistry, brain imaging and stereotactic and functional neurosurgery. Dr...
  54. BIOLOGICAL VANADIUM--MODELS OF STRUCTURE AND REACTIVITY
    VINCENT PECORARO; Fiscal Year: 1990
    ..will be subjected to chemical analysis such as X-ray crystallography, epr, NMR, UV-vis spectroscopies and electrochemistry. The second phase of our work will evaluate the binding properties of vanadium to phytosiderophores and ..
  55. BIOLOGICAL VANADIUM--MODELS OF STRUCTURE AND REACTIVITY
    VINCENT PECORARO; Fiscal Year: 1991
    ..will be subjected to chemical analysis such as X-ray crystallography, epr, NMR, UV-vis spectroscopies and electrochemistry. The second phase of our work will evaluate the binding properties of vanadium to phytosiderophores and ..
  56. BIOLOGICAL VANADIUM--MODELS OF STRUCTURE AND REACTIVITY
    VINCENT PECORARO; Fiscal Year: 1992
    ..will be subjected to chemical analysis such as X-ray crystallography, epr, NMR, UV-vis spectroscopies and electrochemistry. The second phase of our work will evaluate the binding properties of vanadium to phytosiderophores and ..
  57. ELECTROANALYSIS OF NEUROTRANSMITTERS AND MODULATORS
    Robert Wightman; Fiscal Year: 2003
    DESCRIPTION: (Adapted from applicant's abstract) The goals of this research proposal are to develop and use electrochemistry-based probes to monitor neurotransmitters in intact brain tissue...
  58. ELECTROANALYSIS OF NEUROTRANSMITTERS AND MODULATORS
    Robert Wightman; Fiscal Year: 2004
    DESCRIPTION: (Adapted from applicant's abstract) The goals of this research proposal are to develop and use electrochemistry-based probes to monitor neurotransmitters in intact brain tissue...
  59. ELECTROANALYSIS OF NEUROTRANSMITTERS AND MODULATORS
    Robert Wightman; Fiscal Year: 2001
    DESCRIPTION: (Adapted from applicant's abstract) The goals of this research proposal are to develop and use electrochemistry-based probes to monitor neurotransmitters in intact brain tissue...
  60. ELECTROANALYSIS OF NEUROTRANSMITTERS AND MODULATORS
    Robert Wightman; Fiscal Year: 2002
    DESCRIPTION: (Adapted from applicant's abstract) The goals of this research proposal are to develop and use electrochemistry-based probes to monitor neurotransmitters in intact brain tissue...
  61. Redox incuced Metal Transfer Reaction of Metalloproteins
    Feimeng Zhou; Fiscal Year: 2001
    ..the metal-transfer processes induced (modulated) by the redox reactions of immobilized MT molecules using electrochemistry combined on-line with atomic spectroscopic techniques...
  62. IN VITRO OXIDATION OF PSYCHOACTIVE DRUGS
    RICHARD MC CREERY; Fiscal Year: 1980
    It is proposed to use electrochemistry, rapid-scanning spectrophotometry, and liquid chromatography to examine the oxidation of chlorpromazine and related phenothiazines in aqueous solution...
  63. Metals Removal Via Spouted Bed Electrolytic Reactors
    JOSEPH CALO; Fiscal Year: 2005
    ..This approach here will involve investigation of the electrochemistry and recovery of individual metals from a selected set of four (Cd, Cr, Cu and Ni) individual metals, ..
  64. ANALYSIS OF ENDORPHINS BY LC-ELECTROCHEMISTRY
    Norman Reynolds; Fiscal Year: 1990
    ..This LC-EC assays will be especially useful for those studies which require a detailed analysis of endorphin content...
  65. Mechanism of Action of Deep Brain Stimulation
    Kendall H Lee; Fiscal Year: 2010
    ..This program will promote the command of electrophysiology, electrochemistry, brain imaging and stereotactic and functional neurosurgery. Dr...
  66. STICS: Surface-Tethered Iterative Carbohydrate Synthesis
    Keith Stine; Fiscal Year: 2006
    ..The porous gold films will be created on titanium foil, and then characterized using electron microscopy and electrochemistry. The gold surfaces will then be modified with self-assembled monolayers of tri-thiolated derivatives designed ..
  67. STICS: Surface-Tethered Iterative Carbohydrate Synthesis
    Keith Stine; Fiscal Year: 2007
    ..The porous gold films will be created on titanium foil, and then characterized using electron microscopy and electrochemistry. The gold surfaces will then be modified with self-assembled monolayers of tri-thiolated derivatives designed ..
  68. Electrochemical arrays for the detection of small molecule drugs
    KEVIN PLAXCO; Fiscal Year: 2009
    ..The reagentless E-AB platform utilizes electrochemistry to monitor the target-induced folding of an electrode-bound aptamer...