intestinal absorption

Summary

Summary: Uptake of substances through the lining of the INTESTINES.

Top Publications

  1. ncbi A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation
    A T McKie
    Department of Molecular Medicine, King s College London, Guy s, King s, St Thomas School of Medicine, United Kingdom
    Mol Cell 5:299-309. 2000
  2. ncbi Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption
    Scott W Altmann
    Department of Cardiovascular Endocrine Research, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ, 07033 0539, USA
    Science 303:1201-4. 2004
  3. ncbi Chylomicrons promote intestinal absorption of lipopolysaccharides
    Sarbani Ghoshal
    Department of Internal Medicine, Division of Digestive Diseases and Nutrition, University of Kentucky, Lexington, KY, USA
    J Lipid Res 50:90-7. 2009
  4. ncbi The food contaminant deoxynivalenol, decreases intestinal barrier permeability and reduces claudin expression
    Philippe Pinton
    INRA UR66, Toulouse, France
    Toxicol Appl Pharmacol 237:41-8. 2009
  5. pmc Na(+)-D-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion
    Valentin Gorboulev
    Institute of Anatomy and Cell Biology, University of Wurzburg, Wurzburg, Germany
    Diabetes 61:187-96. 2012
  6. ncbi Gastrointestinal persorption and tissue distribution of differently sized colloidal gold nanoparticles
    J F Hillyer
    Department of Animal Health and Biomedical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 1656 Linden Drive, Madison, Wisconsin 53706, USA
    J Pharm Sci 90:1927-36. 2001
  7. ncbi Evaluation of the intestinal absorption of deoxynivalenol and nivalenol by an in vitro gastrointestinal model, and the binding efficacy of activated carbon and other adsorbent materials
    Giuseppina Avantaggiato
    CNR Institute of Sciences of Food Production ISPA, Viale Einaudi 51, I 70125 Bari, Italy
    Food Chem Toxicol 42:817-24. 2004
  8. ncbi Identification of an intestinal heme transporter
    Majid Shayeghi
    Department of Life Sciences, Nutritional Sciences Research Division, Franklin Wilkins Building, Kings College London, 150 Stamford Street, London SE1 9NN, UK
    Cell 122:789-801. 2005
  9. pmc Hypoxia-inducible factor-2α mediates the adaptive increase of intestinal ferroportin during iron deficiency in mice
    Matthew Taylor
    Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor Michigan, USA
    Gastroenterology 140:2044-55. 2011
  10. pmc HIF-2alpha, but not HIF-1alpha, promotes iron absorption in mice
    Maria Mastrogiannaki
    Institut Cochin, Universite Paris Descartes, CNRS, UMR, France
    J Clin Invest 119:1159-66. 2009

Research Grants

  1. Regulation of Bile Acid Synthesis by Nuclear Receptors in Vivo
    Gregorio Gil; Fiscal Year: 2012
  2. Functions of the Human OST-alpha and OST-beta Proteins
    Patricia M Hinkle; Fiscal Year: 2013
  3. 2011 Mechanisms of Membrane Transport Gordon Research Conference
    Nancy Carrasco; Fiscal Year: 2011
  4. Molecular Components Affecting Ocular Retinoid Homeostasis
    JOHANNES FRIEDERICH VONLINTIG; Fiscal Year: 2012
  5. Transferrin Conjugates for Oral Protein Drug Delivery
    Wei Chiang Shen; Fiscal Year: 2013
  6. Structural Biology of the Apical Bile Acid Transporter.
    Peter W Swaan; Fiscal Year: 2012
  7. Divalent metal-ion transporter DMT1 and its role in intestinal metal-ion uptake
    Bryan Mackenzie; Fiscal Year: 2012
  8. EPITHELIAL OXALATE AND CITRATE TRANSPORT
    DAVID BRUCE MOUNT; Fiscal Year: 2011
  9. Mechanism/Regulation of Intestinal Thiamin Uptake
    Hamid M Said; Fiscal Year: 2013
  10. Ligand independent signaling by VDR in Keratinocytes
    Paul N MacDonald; Fiscal Year: 2010

Detail Information

Publications391 found, 100 shown here

  1. ncbi A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation
    A T McKie
    Department of Molecular Medicine, King s College London, Guy s, King s, St Thomas School of Medicine, United Kingdom
    Mol Cell 5:299-309. 2000
    ..IREG1 stimulates iron efflux following expression in Xenopus oocytes. We conclude that IREG1 represents the long-sought duodenal iron export protein and is upregulated in the iron overload disease, hereditary hemochromatosis...
  2. ncbi Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption
    Scott W Altmann
    Department of Cardiovascular Endocrine Research, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ, 07033 0539, USA
    Science 303:1201-4. 2004
    ..Ezetimibe, a drug that inhibits cholesterol absorption, had no effect in NPC1L1 knockout mice, suggesting that NPC1L1 resides in an ezetimibe-sensitive pathway responsible for intestinal cholesterol absorption...
  3. ncbi Chylomicrons promote intestinal absorption of lipopolysaccharides
    Sarbani Ghoshal
    Department of Internal Medicine, Division of Digestive Diseases and Nutrition, University of Kentucky, Lexington, KY, USA
    J Lipid Res 50:90-7. 2009
    Recent data suggest that dietary fat promotes intestinal absorption of lipopolysaccharides (LPS) from the gut microflora, which might contribute to various inflammatory disorders...
  4. ncbi The food contaminant deoxynivalenol, decreases intestinal barrier permeability and reduces claudin expression
    Philippe Pinton
    INRA UR66, Toulouse, France
    Toxicol Appl Pharmacol 237:41-8. 2009
    ..Considering that high levels of DON may be present in food or feed, consumption of DON-contaminated food/feed may induce intestinal damage and has consequences for human and animal health...
  5. pmc Na(+)-D-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion
    Valentin Gorboulev
    Institute of Anatomy and Cell Biology, University of Wurzburg, Wurzburg, Germany
    Diabetes 61:187-96. 2012
    ..The data indicate that SGLT1 is 1) pivotal for intestinal mass absorption of d-glucose, 2) triggers the glucose-induced secretion of GIP and GLP-1, and 3) triggers the upregulation of GLUT2...
  6. ncbi Gastrointestinal persorption and tissue distribution of differently sized colloidal gold nanoparticles
    J F Hillyer
    Department of Animal Health and Biomedical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 1656 Linden Drive, Madison, Wisconsin 53706, USA
    J Pharm Sci 90:1927-36. 2001
    ..To our knowledge this is the first report, at the ultrastructural level, of gastrointestinal uptake of particulates by persorption through holes created by extruding enterocytes...
  7. ncbi Evaluation of the intestinal absorption of deoxynivalenol and nivalenol by an in vitro gastrointestinal model, and the binding efficacy of activated carbon and other adsorbent materials
    Giuseppina Avantaggiato
    CNR Institute of Sciences of Food Production ISPA, Viale Einaudi 51, I 70125 Bari, Italy
    Food Chem Toxicol 42:817-24. 2004
    ..simulating the gastrointestinal (GI) tract of healthy pigs (TIM system) was used to evaluate the small-intestinal absorption of DON and NIV and the efficacy of activated carbon in reducing the relevant absorption...
  8. ncbi Identification of an intestinal heme transporter
    Majid Shayeghi
    Department of Life Sciences, Nutritional Sciences Research Division, Franklin Wilkins Building, Kings College London, 150 Stamford Street, London SE1 9NN, UK
    Cell 122:789-801. 2005
    ..HCP 1 protein was iron regulated and localized to the brush-border membrane of duodenal enterocytes in iron deficiency. Our data indicate that HCP 1 is the long-sought intestinal heme transporter...
  9. pmc Hypoxia-inducible factor-2α mediates the adaptive increase of intestinal ferroportin during iron deficiency in mice
    Matthew Taylor
    Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor Michigan, USA
    Gastroenterology 140:2044-55. 2011
    ..Ferroportin (FPN) is the only characterized, mammalian, basolateral iron exporter. Despite the importance of FPN in maintaining iron homeostasis, its in vivo mechanisms of regulation are unclear...
  10. pmc HIF-2alpha, but not HIF-1alpha, promotes iron absorption in mice
    Maria Mastrogiannaki
    Institut Cochin, Universite Paris Descartes, CNRS, UMR, France
    J Clin Invest 119:1159-66. 2009
    ..This finding may provide a basis for the development of new strategies, specifically in targeting HIF-2alpha, to improve iron homeostasis in patients with iron disorders...
  11. ncbi Bioadhesive polysaccharide in protein delivery system: chitosan nanoparticles improve the intestinal absorption of insulin in vivo
    Yan Pan
    School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, PR China
    Int J Pharm 249:139-47. 2002
    ..Bioadhesive polysaccharide chitosan nanoparticles (CS-NPs) would seem to further enhance intestinal absorption of them...
  12. ncbi Apical GLUT2: a major pathway of intestinal sugar absorption
    George L Kellett
    The University of York, Department of Biology, York YO10 5YW, UK
    Diabetes 54:3056-62. 2005
    ..These mechanisms suggest that apical GLUT2 is a potential therapeutic target for novel dietary or pharmacological approaches to control intestinal sugar delivery and thereby improve glycemic control...
  13. ncbi Cholic acid as key regulator of cholesterol synthesis, intestinal absorption and hepatic storage in mice
    Charlotte Murphy
    Department of Laboratory Medicine, Division of Clinical Chemistry, Karolinska University Hospital, 14186 Stockholm, Sweden
    Biochim Biophys Acta 1735:167-75. 2005
    ..The possibility is discussed that inhibition of CYP8B1 and thus CA synthesis may be beneficial for the treatment of hyperlipidemic disorders...
  14. pmc Microbiota regulate intestinal absorption and metabolism of fatty acids in the zebrafish
    Ivana Semova
    Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Cell Host Microbe 12:277-88. 2012
    ..While intestinal microbiota clearly impact the host's energy balance, their role in intestinal absorption and extraintestinal metabolism of dietary fat is less clear...
  15. ncbi Phosphate homeostasis and the renal-gastrointestinal axis
    Joanne Marks
    Dept of Neuroscience, Physiology, and Pharmacology, Univ College London Medical School, UK
    Am J Physiol Renal Physiol 299:F285-96. 2010
    ....
  16. ncbi Deoxynivalenol transport across human intestinal Caco-2 cells and its effects on cellular metabolism at realistic intestinal concentrations
    Thérèse Sergent
    Laboratoire de Biochimie Cellulaire, Croix du Sud, 5, Institut des Sciences de la Vie and Université Catholique de Louvain, B 1348 Louvain la Neuve, Belgium
    Toxicol Lett 164:167-76. 2006
    ..These data imply that a chronic exposure to DON contaminated foods may negatively affect human health by altering the intestinal mucosa integrity and by inducing the MAPKs implicated in inflammation...
  17. ncbi The mycotoxin deoxynivalenol affects nutrient absorption in human intestinal epithelial cells
    Marc Maresca
    Institut Méditerranéen de Recherche en Nutrition, Unité Mixte de Recherche Institut National de la Recherche Agronomique, Faculté des Sciences de Saint Jérôme, Marseille, France
    J Nutr 132:2723-31. 2002
    ....
  18. ncbi Chitosan nanoparticles enhance the intestinal absorption of the green tea catechins (+)-catechin and (-)-epigallocatechin gallate
    Admire Dube
    Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University Parkville Campus, 381 Royal Parade, Parkville, Victoria, Australia
    Eur J Pharm Sci 41:219-25. 2010
    ..their therapeutic potential is limited by their low oral bioavailability, attributed to poor stability and intestinal absorption. We encapsulated (+)-catechin (C) and (-)-epigallocatechin gallate (EGCg) in chitosan nanoparticles (CS NP)..
  19. ncbi Thiolated carboxymethylcellulose: in vitro evaluation of its permeation enhancing effect on peptide drugs
    A E Clausen
    Centre of Pharmacy, Institute of Pharmaceutical Technology and Biopharmaceutics, University of, Vienna, Austria
    Eur J Pharm Biopharm 51:25-32. 2001
    ....
  20. ncbi Prediction of intestinal permeability
    William J Egan
    Accelrys Inc, ADMET R and D, CN 5350, Princeton, NJ 08543 5350, USA
    Adv Drug Deliv Rev 54:273-89. 2002
    ..e. data quantity, measurement imprecision, confounding factors such as solubility, metabolism, or active efflux, and the need for robust statistical methods, are also discussed...
  21. pmc Intestinal lipid absorption
    Jahangir Iqbal
    Dept of Anatomy, 450 Clarkson Ave, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
    Am J Physiol Endocrinol Metab 296:E1183-94. 2009
    ....
  22. ncbi Postprandial changes in small bowel water content in healthy subjects and patients with irritable bowel syndrome
    Luca Marciani
    Nottingham Digestive Diseases Centre NIHR Biomedical Research Unit, Queen s Medical Centre Campus, Nottingham University Hospitals NHS Trust, University of Nottingham, Nottingham, United Kingdom
    Gastroenterology 138:469-77, 477.e1. 2010
    ..We studied postprandial changes in distribution of water in the upper gastrointestinal tract of healthy volunteers (HVs) and patients with IBS-D after contrasting meals...
  23. ncbi MDCK (Madin-Darby canine kidney) cells: A tool for membrane permeability screening
    J D Irvine
    Affymax Research Institute A Glaxo Wellcome Company, Santa Clara, California 95051
    J Pharm Sci 88:28-33. 1999
    ..58 compared with 0.54 for Caco-2 Papp and human absorption. These results indicate that MDCK cells may be a useful tool for rapid membrane permeability screening...
  24. pmc Green tea as inhibitor of the intestinal absorption of lipids: potential mechanism for its lipid-lowering effect
    Sung I Koo
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269 4017, USA
    J Nutr Biochem 18:179-83. 2007
    ..to be determined, it is evident from in vitro and in vivo studies that green tea or catechins inhibit the intestinal absorption of dietary lipids...
  25. pmc Membrane transporters and folate homeostasis: intestinal absorption and transport into systemic compartments and tissues
    Rongbao Zhao
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Expert Rev Mol Med 11:e4. 2009
    ..This review focuses on the physiological roles of the major folate transporters, with a brief consideration of their impact on the pharmacological activities of antifolates...
  26. ncbi Methylation of dietary flavones greatly improves their hepatic metabolic stability and intestinal absorption
    Thomas Walle
    Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Mol Pharm 4:826-32. 2007
    ..Thus, methylation appears to be a simple and effective way of increasing both metabolic resistance and transport of the flavonoids and, most important, some of their major biological activities...
  27. ncbi Gelatin coated hybrid lipid nanoparticles for oral delivery of amphotericin B
    Sanyog Jain
    Centre for Pharmaceutical Nanotechnology, Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Sector 67, SAS Nagar Mohali, Punjab 160062, India
    Mol Pharm 9:2542-53. 2012
    ..The histopathology of the kidney tissues further confirmed the absence of any changes in the morphology of the renal tubules...
  28. ncbi Review article: fructose malabsorption and the bigger picture
    P R Gibson
    Department of Gastroenterology and Monash University Department of Medicine, Box Hill Hospital, Victoria, Australia
    Aliment Pharmacol Ther 25:349-63. 2007
    ....
  29. pmc The fraction dose absorbed, in humans, and high jejunal human permeability relationship
    Arik Dahan
    Department of Clinical Pharmacology, School of Pharmacy, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Mol Pharm 9:1847-51. 2012
    ..In this situation, the use of multiple permeability experimental methods, including the use of metabolism, which except for luminal degradation requires absorption, is prudent and encouraged...
  30. ncbi Intestinal physiology and peptidase activity in male pigs are modulated by consumption of corn culture extracts containing fumonisins
    Martin Lessard
    Institut National de la Recherche Agronomique Unité Mixte de Recherche 1039, Systèmes d Elevage, Nutrition Animale et Humaine, F 35590 Saint Gilles, France
    J Nutr 139:1303-7. 2009
    ..In conclusion, consumption of an extract rich in fumonisins for 9 d has the potential to alter intestinal physiology, villous architecture, and enzyme activities. Underlying mechanisms remain to be investigated...
  31. ncbi Fructose malabsorption and symptoms of irritable bowel syndrome: guidelines for effective dietary management
    Susan J Shepherd
    Department of Gastroenterology and Monash University, Victoria, Australia
    J Am Diet Assoc 106:1631-9. 2006
    ..01), as was improvement in individual symptoms (P<0.01 for all symptoms). This comprehensive fructose malabsorption dietary therapy achieves a high level of sustained adherence and good symptomatic response...
  32. ncbi Pharmacology, efficacy and safety of oral phosphate binders
    Alastair J Hutchison
    Manchester Biomedical Research Centre, Manchester Royal Infirmary Renal Unit, Oxford Road, Manchester M13 9WL, UK
    Nat Rev Nephrol 7:578-89. 2011
    ..Without such a study we will continue to rely on observational data with all its uncertainties and potential to mislead...
  33. ncbi In vitro study of transporters involved in intestinal absorption of inorganic arsenic
    Marta Calatayud
    Instituto de Agroquimica y Tecnologia de Alimentos CSIC, Av Agustín Escardino, 7, 46980 Paterna, Valencia, Spain
    Chem Res Toxicol 25:446-53. 2012
    ..anion transporting polypeptides (OATPs), aquaporins (AQPs), and phosphate transporters (NaPi and PiT)] in intestinal absorption of As(V) and As(III), using the Caco-2 cell line as a model of the intestinal epithelium...
  34. ncbi Emerging trends in oral delivery of peptide and protein drugs
    Ram I Mahato
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Crit Rev Ther Drug Carrier Syst 20:153-214. 2003
    ..The roles of P-glycoprotein and CYP3A4 in controlling the extent of intestinal absorption and metabolism will also be discussed.
  35. pmc Simple-sugar meals target GLUT2 at enterocyte apical membranes to improve sugar absorption: a study in GLUT2-null mice
    F Gouyon
    INSERM U505, UPMC, Paris, France
    J Physiol 552:823-32. 2003
    ..We also observe that a large improvement of intestinal absorption is promoted by the transient recruitment of food-facing GLUT2, induced by the ingestion of a simple-sugar ..
  36. ncbi Compensatory increase in hepatic lipogenesis in mice with conditional intestine-specific Mttp deficiency
    Yan Xie
    Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 281:4075-86. 2006
    ..These findings establish distinctive features for MTTP involvement in intestinal chylomicron assembly and secretion and suggest that hepatic lipogenesis undergoes compensatory induction in the face of defective intestinal TG secretion...
  37. ncbi The intestine as a possible target for fumonisin toxicity
    Sandrine Bouhet
    Laboratoire de Pharmacologie Toxicologie, INRA, Toulouse, France
    Mol Nutr Food Res 51:925-31. 2007
    ....
  38. pmc Role of the intestinal tight junction modulator zonulin in the pathogenesis of type I diabetes in BB diabetic-prone rats
    Tammara Watts
    Mucosal Biology Research Center and Division of Pediatric Gastroenterology and Nutrition, and Division of Pediatric Research, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 102:2916-21. 2005
    ..Combined together, these findings suggest that the zonulin-induced loss in small intestinal barrier function is involved in the pathogenesis of T1D in the BB diabetic-prone animal model...
  39. pmc PPARalpha-mediated effects of dietary lipids on intestinal barrier gene expression
    Heleen M de Vogel-van den Bosch
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, PO Box 8129, NL 6700EV, Wageningen, The Netherlands
    BMC Genomics 9:231. 2008
    ..To this end we used triacylglycerols composed of identical fatty acids in combination with gene expression profiling in wild-type and PPARalpha-null mice. Treatment with the synthetic PPARalpha agonist WY14643 served as reference...
  40. ncbi Inhibitory effect of calcium on non-heme iron absorption may be related to translocation of DMT-1 at the apical membrane of enterocytes
    Ben A V Thompson
    School of Medicine, University of East Anglia, Norwich NR4 7TJ, UK
    J Agric Food Chem 58:8414-7. 2010
    ..No change was seen in ferroportin expression. Our data suggest that calcium reduces iron bioavailability by decreasing DMT-1 expression at the apical cell membrane, thereby downregulating iron transport into the cell...
  41. pmc Enabling the intestinal absorption of highly polar antiviral agents: ion-pair facilitated membrane permeation of zanamivir heptyl ester and guanidino oseltamivir
    Jonathan M Miller
    Center for Molecular Drug Targeting, Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, USA
    Mol Pharm 7:1223-34. 2010
    ..The goal of this work was to enhance the intestinal absorption of the low-permeability antiviral agents zanamivir heptyl ester (ZHE) and guanidino oseltamivir (GO) ..
  42. pmc Conditional Gata4 deletion in mice induces bile acid absorption in the proximal small intestine
    Eva Beuling
    GI Cell Biology, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
    Gut 59:888-95. 2010
    ....
  43. ncbi Genetic polymorphisms of OATP transporters and their impact on intestinal absorption and hepatic disposition of drugs
    Takeo Nakanishi
    Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Pharmacy, Kanazawa University, Kanazawa, Japan
    Drug Metab Pharmacokinet 27:106-21. 2012
    ..and OATP1B3 contributes to the hepatic uptake of drugs from the portal vein, and OATP2B1 may alter their intestinal absorption as well as hepatic extraction...
  44. pmc The digestive adaptation of flying vertebrates: high intestinal paracellular absorption compensates for smaller guts
    Enrique Caviedes-Vidal
    Laboratorio de Biología Prof E Caviedes Codelia, Facultad de Ciencias Humanas, and Departamento de Bioquímica y Ciencias Biológicas, Universidad Nacional de San Luís Consejo Nacional de Investigaciones Científicas y Técnicas, 5700 San Luis, Argentina
    Proc Natl Acad Sci U S A 104:19132-7. 2007
    ..Here, we further show that an enhanced paracellular pathway for intestinal absorption of water-soluble nutrients such as glucose and amino acids may compensate for reduced small intestines in ..
  45. pmc Intestinal absorption and first-pass metabolism of polyphenol compounds in rat and their transport dynamics in Caco-2 cells
    Zenghui Teng
    Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi an, People s Republic of China
    PLoS ONE 7:e29647. 2012
    ..The relationship between their chemical structure and intestinal absorption, transport, and first-pass metabolism remains unresolved, however.
  46. ncbi Helodermin-loaded nanoparticles: characterization and transport across an in vitro model of the follicle-associated epithelium
    Anne des Rieux
    Unite de Pharmacie Galenique, Universite Catholique de Louvain, Brussels, Belgium
    J Control Release 118:294-302. 2007
    ..Transport of free and encapsulated helodermin occurred most probably by endocytosis. In conclusion, M cells improved helodermin transport across the intestinal epithelium, confirming their high potential for oral delivery of peptides...
  47. ncbi An iron-regulated ferric reductase associated with the absorption of dietary iron
    A T McKie
    Department of Molecular Medicine, Guy s, King s and St Thomas School of Medicine, King s College London, Rayne Institute, Denmark Hill Campus, 123 Coldharbour Lane, London SE5 9NU, UK
    Science 291:1755-9. 2001
    ..Duodenal expression levels of Dcytb messenger RNA and protein were regulated by changes in physiological modulators of iron absorption. Thus, Dcytb provides an important element in the iron absorption pathway...
  48. ncbi Seasonal variation in amount of unabsorbed dietary carbohydrate from the intestine after breakfast in young female Thai subjects: comparison with that of Japanese subjects
    Yuki Tsumura
    Department of Food and Nutrition Studies, Junshin Junior College, Thailand
    J Physiol Anthropol 29:141-7. 2010
    ..These results suggest that differences in seasonal change in a living environment have different effects on seasonal variations in the efficiency of carbohydrate absorption in the intestine after breakfast...
  49. pmc Fatty acid- and cholesterol transporter protein expression along the human intestinal tract
    Christiaan J Masson
    Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
    PLoS ONE 5:e10380. 2010
    ..Protein distribution profiles along the human intestinal tract of transporters involved in the absorption of cholesterol and long-chain fatty acids (LCFA) have been scarcely evaluated...
  50. pmc Influence of class B scavenger receptors on cholesterol flux across the brush border membrane and intestinal absorption
    David V Nguyen
    Gastroenterology, Hepatology, and Nutrition Division, Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4318, USA
    J Lipid Res 50:2235-44. 2009
    ....
  51. ncbi Efficacy and tolerability of Creon for Children in infants and toddlers with pancreatic exocrine insufficiency caused by cystic fibrosis: an open-label, single-arm, multicenter study
    Carla Colombo
    CF Center of Milano, Fondazione IRCCS Ospedale Policlinico, Mangiagalli, Regina Elena, Milano, and University of Milan, Milan, Italy
    Pancreas 38:693-9. 2009
    ..To evaluate the efficacy and safety of a pancreatic enzyme preparation specifically developed for infants and small children with cystic fibrosis (CF)...
  52. ncbi Low bioavailability of dietary epoxyxanthophylls in humans
    Akira Asai
    National Food Research Institute, NARO, 2 1 12 Kannondai, Tsukuba, Ibaraki 305 8642, Japan
    Br J Nutr 100:273-7. 2008
    ..However, there is little information about the intestinal absorption and metabolic fate of dietary epoxyxanthophylls in humans...
  53. ncbi ATP-binding cassette transporter A1 is significantly involved in the intestinal absorption of alpha- and gamma-tocopherol but not in that of retinyl palmitate in mice
    Emmanuelle Reboul
    INRA, UMR1260, Nutriments Lipidiques et Prévention des Maladies Métaboliques, INSERM, U476, Université Aix Marseille 1, Université Aix Marseille 2, Faculte de Medecine, IPHM IFR 125, Marseille, France
    Am J Clin Nutr 89:177-84. 2009
    ..It has long been assumed that newly absorbed vitamin A and E enter the body only via enterocyte-produced chylomicrons. However, recent results in cell cultures have shown that a fraction of alpha-tocopherol is secreted with intestinal HDL...
  54. pmc ISX is a retinoic acid-sensitive gatekeeper that controls intestinal beta,beta-carotene absorption and vitamin A production
    Glenn P Lobo
    Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44160, USA
    FASEB J 24:1656-66. 2010
    ..The role of SR-BI in the intestinal absorption of other dietary lipids, including cholesterol, fatty acids, and tocopherols, implicates retinoid ..
  55. ncbi Predicting the impact of physiological and biochemical processes on oral drug bioavailability
    B Agoram
    Simulations Plus, Inc. 1220 W. Avenue J, Lancaster, CA 93534-2902, USA
    Adv Drug Deliv Rev 50:S41-67. 2001
    ..time profiles for common drugs and compare those estimates to literature data. We illustrate the simulated impact of physiological and biochemical processes on oral drug bioavailability...
  56. ncbi Intestinal ferritin H is required for an accurate control of iron absorption
    Liviu Vanoaica
    ISREC Swiss Institute for Experimental Cancer Research, Lausanne, Switzerland
    Cell Metab 12:273-82. 2010
    ..Our results demonstrate that hepcidin-mediated regulation alone is insufficient to restrict iron absorption and that intestinal ferritin H is also required to limit iron efflux from intestinal cells...
  57. ncbi Intestinal absorption enhancement via the paracellular route by fatty acids, chitosans and others: a target for drug delivery
    María José Cano-Cebrián
    Departamento de Farmacia y Tecnologia Farmaceutica, Facultad de Farmacia, Universidad de Valencia, Burjassot Valencia, Spain
    Curr Drug Deliv 2:9-22. 2005
    ..The few studies performed in vivo are also presented. In addition, the findings of recent absorption enhancers, such as zonula occludens toxin or thiolated polymers, are reviewed...
  58. ncbi Permeability, zonulin production, and enteropathy in dermatitis herpetiformis
    Edgardo Smecuol
    Dr C Bonorino Udaondo Gastroenterology Hospital, Av Caseros 2061, 1264 Buenos Aires, Argentina
    Clin Gastroenterol Hepatol 3:335-41. 2005
    ..Our aim was to assess both intestinal permeability and serum zonulin levels in a group of patients with DH having variable grades of enteropathy...
  59. ncbi Tight junction modulation and its relationship to drug delivery
    Noha N Salama
    Pharmacokinetics Biopharmaceutics Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland at Baltimore, 100 Penn Street, Baltimore, Maryland 21201, USA
    Adv Drug Deliv Rev 58:15-28. 2006
    ..Above all, the transient opening of the TJs by Zot suggests that it could be used as a novel approach for the safe drug delivery of therapeutic agents...
  60. ncbi Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers
    Ina Hubatsch
    Department of Pharmacy, Uppsala University, Uppsala, Sweden
    Nat Protoc 2:2111-9. 2007
    ..The permeability assay can be completed within one working day, provided that the Caco-2 monolayers have been cultured and differentiated on the permeable supports 3 weeks in advance...
  61. ncbi Absorption, metabolism and excretion of 3-acetyl DON in pigs
    G S Eriksen
    Department of Animal Nutrition and Management, Swedish University of Agricultural Sciences, Uppsala, Sweden
    Arch Tierernahr 57:335-45. 2003
    ..Furthermore, the experiment shows that the main part of DON is rapidly excreted and does not accumulate in plasma, but a minor part of the toxin is retained and slowly excreted from the pigs...
  62. ncbi Intestinal lymphatic drug transport: an update
    C J Porter
    Department of Pharmaceutics, Victorian College of Pharmacy, Monash University Parkville Campus, 381 Royal Parade, Parkville, Victoria 3052, Australia
    Adv Drug Deliv Rev 50:61-80. 2001
    ..Finally the possible future directions for studies of intestinal lymphatic transport are discussed, including the use of cell culture models and genetically modified animals...
  63. ncbi Modulation of intestinal P-glycoprotein function by cremophor EL and other surfactants by an in vitro diffusion chamber method using the isolated rat intestinal membranes
    Yasushi Shono
    Department of Biopharmaceutics, Kyoto Pharmaceutical University, Misasagi Yamashina ku, Kyoto 607 8414 Japan
    J Pharm Sci 93:877-85. 2004
    ..suggested that charge of surfactants was possibly related to the action of these surfactants on the intestinal absorption of P-gp substrates...
  64. ncbi Oral delivery of peptide drugs: barriers and developments
    Josias H Hamman
    School of Pharmacy, Tshwane University of Technology, Pretoria, South Africa
    BioDrugs 19:165-77. 2005
    ..A considerable amount of research has focused on overcoming the challenges presented by these intestinal absorption barriers to provide effective oral delivery of peptide and protein drugs...
  65. pmc Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study
    Luigi Ferrucci
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, United States of America
    Am J Hum Genet 84:123-33. 2009
    ..002). Our findings might shed light on the controversial relationship between lipid-soluble anti-oxidant nutrients and human health...
  66. ncbi Lipid-based delivery systems for improving the bioavailability and lymphatic transport of a poorly water-soluble LTB4 inhibitor
    D J Hauss
    Department of Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, Connecticut 06877 0368, USA
    J Pharm Sci 87:164-9. 1998
    ....
  67. ncbi On the toxicokinetics and the metabolism of deoxynivalenol (DON) in the pig
    S Danicke
    Institute of Animal Nutrition, Federal Agricultural Research Centre FAL Braunschweig, Germany
    Arch Anim Nutr 58:169-80. 2004
    ..It was concluded that de-epoxydation of DON, which primarily occurs in the hindgut, probably does not contribute much to a detoxification in the pig...
  68. ncbi The mycotoxin ochratoxin A alters intestinal barrier and absorption functions but has no effect on chloride secretion
    M Maresca
    , , 13397 Marseille Cedex 20, France
    Toxicol Appl Pharmacol 176:54-63. 2001
    ..Taken together, these data showed that OTA alters both barrier and absorption functions of the intestinal epithelium...
  69. ncbi Cholesterol absorption is mainly regulated by the jejunal and ileal ATP-binding cassette sterol efflux transporters Abcg5 and Abcg8 in mice
    Li ping Duan
    Department of Medicine, Liver Center and Gastroenterology Division, Beth Israel Deaconess Medical Center, Harvard Medical School and Harvard Digestive Diseases Center, 330 Brookline Avenue, DA 601, Boston, MA 02215, USA
    J Lipid Res 45:1312-23. 2004
    ..We conclude that Ch absorption is mainly regulated by the jejunal and ileal Abcg5 and Abcg8 in mice...
  70. ncbi Absorption of fumonisin B1 and aminopentol on an in vitro model of intestinal epithelium; the role of P-glycoprotein
    I De Angelis
    Department of Environment and Primary Prevention, Toxicity Mechanism Unit, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Toxicon 45:285-91. 2005
    ....
  71. ncbi Intestinal absorption of dietary cholesteryl ester is decreased but retinyl ester absorption is normal in carboxyl ester lipase knockout mice
    W Weng
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York 10021, USA
    Biochemistry 38:4143-9. 1999
    ..Other suggested roles for CEL include the direct facilitation of the intestinal absorption of free cholesterol and the modification of plasma lipoproteins...
  72. ncbi High cholesterol absorption efficiency and rapid biliary secretion of chylomicron remnant cholesterol enhance cholelithogenesis in gallstone-susceptible mice
    David Q H Wang
    Department of Medicine, Harvard Medical School and Harvard Digestive Diseases Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Biochim Biophys Acta 1733:90-9. 2005
    ..Differential metabolism of the chylomicron remnant cholesterol between C57L and AKR mice clearly plays a crucial role in the formation of lithogenic bile and gallstones...
  73. ncbi Diet-derived advanced glycation end products are major contributors to the body's AGE pool and induce inflammation in healthy subjects
    Jaime Uribarri
    Division of Nephrology, Deparment of Medicine, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
    Ann N Y Acad Sci 1043:461-6. 2005
    ..Together with previous evidence from diabetics and renal failure patients, these data suggest that dietary AGEs may play an important role in the causation of chronic diseases associated with underlying inflammation...
  74. ncbi Intestinal absorption of dietary carotenoids
    Lina Yonekura
    National Food Research Institute, Tsukuba, Ibaraki, Japan
    Mol Nutr Food Res 51:107-15. 2007
    ..Comparisons between the intestinal absorption of a wide array of carotenoids would be useful to elucidate the absorption mechanism of each carotenoid ..
  75. pmc CD36 mediates both cellular uptake of very long chain fatty acids and their intestinal absorption in mice
    Victor A Drover
    Department of Pharmacology, State University of New York, Stony Brook, New York 11794, USA
    J Biol Chem 283:13108-15. 2008
    ..Together, these findings represent the first direct evidence for protein-facilitated FA absorption in the intestine and identify a novel therapeutic target for the treatment of diseases characterized by elevated VLCFA levels...
  76. ncbi Nanoparticles as potential oral delivery systems of proteins and vaccines: a mechanistic approach
    Anne des Rieux
    Universite Catholique de Louvain, Unite de Pharmacie Galenique, avenue E Mounier, 73 20, 1200 Brussels, Belgium
    J Control Release 116:1-27. 2006
    ..Encouraging results upon in vivo testing are reported but low bioavailability and lack of control on absorbed dose slow down products development. Vaccines are certainly the most promising applications for orally delivered nanoparticles...
  77. ncbi Dietary polyphenols decrease glucose uptake by human intestinal Caco-2 cells
    Kelly Johnston
    Centre for Nutrition and Food Safety, School of Biomedical and Molecular Sciences, University of Surrey, Guildford, Surrey GU2 7XH, UK
    FEBS Lett 579:1653-7. 2005
    ..The non-glycosylated dietary polyphenols appear to exert their effects via steric hindrance, and (-)-epigallochatechingallate, (-)-epichatechingallate and (-)-epigallochatechin are effective against both transporters...
  78. ncbi Docetaxel microemulsion for enhanced oral bioavailability: preparation and in vitro and in vivo evaluation
    Yong Mei Yin
    College of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China
    J Control Release 140:86-94. 2009
    ..These results encourage further development of docetaxel microemulsions as an oral drug delivery system...
  79. ncbi Molecular cloning and characterization of a channel-like transporter mediating intestinal calcium absorption
    J B Peng
    Membrane Biology Program, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 274:22739-46. 1999
    ..Our studies strongly suggest that CaT1 provides the principal mechanism for Ca(2+) entry into enterocytes as part of the transcellular pathway of calcium absorption in the intestine...
  80. ncbi P-glycoprotein inhibitors and their screening: a perspective from bioavailability enhancement
    Manthena V S Varma
    Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Phase X, Sector 67, 160062 Punjab, SAS Nagar, India
    Pharmacol Res 48:347-59. 2003
    ..Inhibition of P-glycoprotein improves intestinal absorption and tissue distribution while reducing the substrate metabolism and its elimination...
  81. ncbi A novel, noninvasive method for the measurement of intestinal fat absorption
    Ronald J Jandacek
    University of Cincinnati, College of Medicine, Department of Pathology, Ohio 45267, USA
    Gastroenterology 127:139-44. 2004
    ..The goal of the study was to facilitate fat balance measurements with an appropriate intestinal marker for the transit of dietary fat and thereby eliminate the need for complete diet and fecal collections...
  82. pmc Reducing small intestinal permeability attenuates colitis in the IL10 gene-deficient mouse
    M C Arrieta
    Department of Medicine, University of Alberta, Walter C Mackenzie Health Science Ctre, Edmonton, AB, Canada
    Gut 58:41-8. 2009
    ..Furthermore, the development of colitis is dependent upon luminal agents, as animals do not develop disease if raised under germ-free conditions...
  83. ncbi Carotenoid bioavailability and bioconversion
    Kyung Jin Yeum
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Annu Rev Nutr 22:483-504. 2002
    ....
  84. ncbi Physiology and molecular biology of dietary iron absorption
    Silvia Miret
    Department of Life Sciences, King s College London, The Franklin Wilkins Building, London
    Annu Rev Nutr 23:283-301. 2003
  85. ncbi Characterization of water-in-oil microemulsion for oral delivery of earthworm fibrinolytic enzyme
    Mao Bo Cheng
    Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China
    J Control Release 129:41-8. 2008
    ..These findings indicated that the w/o microemulsion may represent a safe and effective oral delivery system for hydrophilic bioactivity macromolecules...
  86. ncbi The cholesterol absorption inhibitor ezetimibe acts by blocking the sterol-induced internalization of NPC1L1
    Liang Ge
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Cell Metab 7:508-19. 2008
    ..Together, our data suggest a model wherein cholesterol is internalized into cells with NPC1L1 through clathrin/AP2-mediated endocytosis and ezetimibe inhibits cholesterol absorption by blocking the internalization of NPC1L1...
  87. ncbi Mechanisms underlying saturable intestinal absorption of metformin
    William R Proctor
    Division of Molecular Pharmaceutics, Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Drug Metab Dispos 36:1650-8. 2008
    ..This report provides strong evidence for a saturable mechanism in the paracellular space and provides insight into possible mechanisms for the dose dependence of metformin absorption in vivo...
  88. ncbi DGAT1 is not essential for intestinal triacylglycerol absorption or chylomicron synthesis
    Kimberly K Buhman
    Gladstone Institute of Cardiovascular Disease, San Francisco, California 94141 9100, USA
    J Biol Chem 277:25474-9. 2002
    ..Our findings indicate that multiple mechanisms for triacylglycerol synthesis in the intestine facilitate triacylglycerol absorption...
  89. ncbi Uncoupling of intestinal mitochondrial oxidative phosphorylation and inhibition of cyclooxygenase are required for the development of NSAID-enteropathy in the rat
    S Somasundaram
    Departments of Medicine and Surgery, Guy s, King s and St Thomas Medical School, Camberwell, UK
    Aliment Pharmacol Ther 14:639-50. 2000
    ..One suggestion is that the nonprostaglandin mechanism involves uncoupling of mitochondrial oxidative phosphorylation...
  90. ncbi Selective sterol accumulation in ABCG5/ABCG8-deficient mice
    Liqing Yu
    McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    J Lipid Res 45:301-7. 2004
    The ATP binding cassette (ABC) transporters ABCG5 and ABCG8 limit intestinal absorption and promote biliary secretion of neutral sterols...
  91. ncbi How should we assess the effects of exposure to dietary polyphenols in vitro?
    Paul A Kroon
    Nutrition Division, Institute of Food Research, Norwich, United Kingdom
    Am J Clin Nutr 80:15-21. 2004
    ..1-10 micromol/L. For correct interpretation of results, future efforts to define biological activities of polyphenols must make use of the available data concerning bioavailability and metabolism in humans...
  92. pmc Augmented increase in tight junction permeability by luminal stimuli in the non-inflamed ileum of Crohn's disease
    J D Soderholm
    Department of Surgery and Clinical Research Centre, University Hospital, Linkoping, Sweden
    Gut 50:307-13. 2002
    ..The luminal contents are important for development of neoinflammation following resection. Regulation of tight junctions by luminal factors has not previously been studied in Crohn's disease...
  93. ncbi Intestinal permeability and irritable bowel syndrome
    M Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research Group, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Neurogastroenterol Motil 19:545-52. 2007
    ....
  94. ncbi Cholesterol absorption efficiency and sterol metabolism in obesity
    T A Miettinen
    Department of Medicine, Division of Internal Medicine, University of Helsinki, P O Box 340, FIN 00029 HYKS, Helsinki, Finland
    Atherosclerosis 153:241-8. 2000
    ..These mechanisms could have contributed to changes in metabolism of non-cholesterol sterols, especially of cholestanol and plant sterols...
  95. ncbi Current strategies used to enhance the paracellular transport of therapeutic polypeptides across the intestinal epithelium
    Nazila Salamat-Miller
    Division of Pharmaceutical Sciences, Room 211A, School of Pharmacy, University of Missouri Kansas City, Kansas City, MO 64110 2499, USA
    Int J Pharm 294:201-16. 2005
    ....
  96. ncbi Protein drug oral delivery: the recent progress
    Hye J Lee
    College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Kwanak gu, Korea
    Arch Pharm Res 25:572-84. 2002
    ..This review provides a summary of the novel approaches currently in progress in the protein oral delivery followed by factors affecting protein oral absorption...
  97. ncbi Effects of probiotic therapy in critically ill patients: a randomized, double-blind, placebo-controlled trial
    Cathy Alberda
    Royal Alexandra Hospital, Edmonton, Canada, University of Alberta, Edmonton, Canada
    Am J Clin Nutr 85:816-23. 2007
    ..A breakdown in gut barrier function and immune dysfunction are associated with the onset of MODS. Probiotic bacteria have been shown to modulate intestinal barrier and immune function...
  98. ncbi Microemulsion formulation for enhanced absorption of poorly soluble drugs. II. In vivo study
    Kohsaku Kawakami
    Developmental Research Laboratories, Shionogi and Co, Ltd, 12 4 Sagisu 5 chome, Fukushima ku, 553 0002, Osaka, Japan
    J Control Release 81:75-82. 2002
    ..HCO-60 and Tween 80-based formulations were mild to the organs, while BL-9EX-based formulation caused serious damage. The behavior and absorption mechanism of the microemulsion formulations are discussed...
  99. pmc Dietary oxidized n-3 PUFA induce oxidative stress and inflammation: role of intestinal absorption of 4-HHE and reactivity in intestinal cells
    Manar Awada
    INRA, U1235 CarMeN laboratory, F 69621 Villeurbanne, France
    J Lipid Res 53:2069-80. 2012
    ..We therefore studied such effects and hypothesized the involvement of the intestinal absorption of 4-hydroxy-2-hexenal (4-HHE), an oxidized n-3 PUFA end-product...
  100. ncbi Prediction of intestinal first-pass drug metabolism
    Jiansong Yang
    Simcyp Limited, Blades Enterprise Centre, Sheffield, UK
    Curr Drug Metab 8:676-84. 2007
    ..The former overpredicts the fraction escaping first-pass gut metabolism; the latter improves the predictions by accounting for interplay between permeability and metabolism...
  101. ncbi Deoxynivalenol affects in vitro intestinal epithelial cell barrier integrity through inhibition of protein synthesis
    Jacqueline Van De Walle
    Institut des Sciences de la Vie and UCLouvain, B 1348 Louvain la Neuve, Belgium
    Toxicol Appl Pharmacol 245:291-8. 2010
    ....

Research Grants66

  1. Regulation of Bile Acid Synthesis by Nuclear Receptors in Vivo
    Gregorio Gil; Fiscal Year: 2012
    Bile acids are required for intestinal absorption and biliary solubilization of cholesterol and lipids. In addition, bile acids play a crucial role in cholesterol homeostasis...
  2. Functions of the Human OST-alpha and OST-beta Proteins
    Patricia M Hinkle; Fiscal Year: 2013
    ..Because the enterohepatic circulation of bile acids is essential for processes such as intestinal absorption of dietary fats and vitamins, cholesterol homeostasis, bile flow, and biliary lipid secretion, these data ..
  3. 2011 Mechanisms of Membrane Transport Gordon Research Conference
    Nancy Carrasco; Fiscal Year: 2011
    ..to human health: transporters and channels are key elements in renal regulation of serum ion levels, intestinal absorption of nutrients, and neuronal modulation of signaling, among a host of other processes...
  4. Molecular Components Affecting Ocular Retinoid Homeostasis
    JOHANNES FRIEDERICH VONLINTIG; Fiscal Year: 2012
    ..objective of the proposed studies is to analyze two key steps affecting ocular retinoid metabolism: the intestinal absorption and metabolic conversion of b,b-carotene to retinol and the uptake of b,b-carotene-derived retinol into ..
  5. Transferrin Conjugates for Oral Protein Drug Delivery
    Wei Chiang Shen; Fiscal Year: 2013
    ..Although the feasibility of TfR- mediated intestinal absorption of protein drugs has been demonstrated in our and others'laboratories, the in vivo modification of ..
  6. Structural Biology of the Apical Bile Acid Transporter.
    Peter W Swaan; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Bile acids play an invaluable role in the intestinal absorption of food-derived lipids and lipid-soluble vitamins and drugs...
  7. Divalent metal-ion transporter DMT1 and its role in intestinal metal-ion uptake
    Bryan Mackenzie; Fiscal Year: 2012
    ..provided by applicant): DMT1 is a widely-expressed iron transporter that is essential for adequate intestinal absorption of iron and for transport of iron in red blood cell precursors for the production of hemoglobin...
  8. EPITHELIAL OXALATE AND CITRATE TRANSPORT
    DAVID BRUCE MOUNT; Fiscal Year: 2011
    ..The intestinal absorption of oxalate may in turn be a major determinant of its excretion in the urine and the natural history of ..
  9. Mechanism/Regulation of Intestinal Thiamin Uptake
    Hamid M Said; Fiscal Year: 2013
    ..application is to continue our investigations into the cellular and molecular mechanisms involved in the intestinal absorption process of the water- soluble vitamin B1 (thiamin) and their regulation...
  10. Ligand independent signaling by VDR in Keratinocytes
    Paul N MacDonald; Fiscal Year: 2010
    ..1,25-dihydroxyvitamin D3 (1,25(OH)2D3) is to maintain appropriate calcium homeostasis by ensuring adequate intestinal absorption of dietary calcium...
  11. Proton-coupled folate/antifolate transport
    ISRAEL DAVID GOLDMAN; Fiscal Year: 2013
    ..From a physiological perspective, PCFT plays a critical role in intestinal absorption of folates and the maintenance of folate sufficiency...
  12. Intestinal Vitamin B2 Absorption: Molecular/Cellular Aspects and Effects of Alcoh
    Hamid M Said; Fiscal Year: 2013
    ..of this application are to characterize the molecular mechanisms involved in the regulation of the intestinal absorption of vitamin B2 (riboflavin, RF), and those involved in intracellular trafficking and membrane targeting of ..
  13. Oral prodrug of a novel antiviral that blocks neuronal reactivation of HSV
    George E Wright; Fiscal Year: 2012
    ..formulate the pro-drug Sacrovir (6-deoxy-mCF3PG) to enhance its intestinal absorption;strategies include emulsions, small molecule adjuvants, and solubility enhancers;2...
  14. Drosophila model of oxalate nephrolithiasis
    Michael F Romero; Fiscal Year: 2013
    ..Slc26a6 is an electrogenic Cl-/ox2- exchanger involved in both intestinal absorption and renal excretion of oxalate. Slc26a6 knockout mice develop hyperoxaluria and CaOx stones...
  15. Oral paclitaxel solubilized and bioenhanced by food compound for cancer therapy
    Zhijun Liu; Fiscal Year: 2013
    ..NANO-PTX attained a permeability coefficient that predicts 65% intestinal absorption whereas the naked PTX is nearly impermeable...
  16. Intestinal Biotin Absorption: Physiological, Cellular and Molecular Aspects
    Hamid M Said; Fiscal Year: 2013
    ..application is to continue our investigations into the physiology and cell/molecular biology of the intestinal absorption process of the water-soluble vitamin biotin...
  17. Role of Rab proteins in hSVCT1 cell biology in intestinal epithelial cells
    Veedamali S Subramanian; Fiscal Year: 2010
    ..C is an essential nutrient for human well-being and cannot be synthesized, obtains it from diet via intestinal absorption. Human intestine plays a role in regulating and maintaining body vitamin C homeostasis, studies on the ..
  18. Cranberry: Interactions with Anti-infectious Agents
    Gail Anderson; Fiscal Year: 2005
    ..e., intestinal) drug transporter function. The intestinal absorption of many beta-lactam antibiotics is mediated by peptide transporters (e.g. PepT1) and possibly OATP...
  19. Mechanisms Regulating Non-biliary Fecal Sterol Loss
    Jonathan Mark Brown; Fiscal Year: 2010
    ..It is generally accepted that cholesterol enters the body via intestinal absorption or endogenous synthesis, and is excreted out of the body via a hepatobiliary route, either as free sterol ..
  20. Absorption, Metabolism and Biodistribution of Prions after Oral Ingestion
    Claudio Soto; Fiscal Year: 2013
    ..manner the initial fate of prions upon oral exposure, including the estimation of gut metabolism, intestinal absorption, excretion, whole body tissue distribution, and brain uptake...
  21. BIOCHEMISTRY OF PROTEIN PRENYLATION
    Christophe L M J Verlinde; Fiscal Year: 2012
    ..In vitro assessment of drug metabolism and intestinal absorption will be used to screen potent PFT inhibitors...
  22. Mechanisms Regulating Non-biliary Fecal Sterol Loss
    Jonathan Mark Brown; Fiscal Year: 2013
    ..It is generally accepted that cholesterol enters the body via intestinal absorption or endogenous synthesis, and is excreted out of the body via a hepatobiliary route, either as free sterol ..
  23. Role and Relevance of Pept1 in Drug Absorption, Disposition, and Dynamics
    David E Smith; Fiscal Year: 2013
    ..oligopeptide transporter (POT) of the SLC15 family, has nutritional importance because of its intestinal absorption of small peptides from the diet and because of its reabsorption of peptide-bound amino nitrogen from ..
  24. High throughput screens for fatty acid uptake inhibitors
    Concetta C DiRusso; Fiscal Year: 2013
    ..We also expect some of the compounds we identify may be employed to specifically reduce intestinal absorption as a primary step in preventing absorption of excess fat calories...
  25. Milk-based nano-delivery system for hydrophobic drugs in infants and children
    Tomas Martin-Jimenez; Fiscal Year: 2012
    ..The central hypothesis is that the casein micelle can be modified to facilitate the intestinal absorption of hydrophobic molecules...
  26. Chemoprevention of lung cancer with red ginseng extracts
    Ming You; Fiscal Year: 2012
    ..via in vitro activity- guided fractionation chromatographic separation supplemented by measuring their intestinal absorption potentials...
  27. Protection against radiation-induced damage to intestinal nutrient transport
    Roger Howell; Fiscal Year: 2009
    ..For almost all nutrients, the rate-limiting step of intestinal absorption is transport across the apical membrane...
  28. Role of a Novel Absorption Mechanism in Metformin Disposition and Pharmacology
    Dhiren R Thakker; Fiscal Year: 2013
    ..S. Food and Drug Administration in 1994, yet the mechanisms involved in its intestinal absorption and its pharmacologic actions are not well understood to date...
  29. HFE: A Genetic Determinant of Olfactory Mn Absorption and Toxicity
    Marianne Wessling Resnick; Fiscal Year: 2010
    ..The missense variants C282Y and H63D promote increased intestinal absorption and progressive tissue deposition of iron...
  30. Dietary Oxalate and Kidney Stone Formation
    DEAN GEORGE ASSIMOS; Fiscal Year: 2010
    ..The second aim is to clarify the role of the oxalate-degrading organism, Oxalobacter formigenes in large intestinal absorption. The third aim seeks to translate these findings into directed therapies that prevent stone recurrence...
  31. Cellular models of microvillus inclusion disease
    H Lee Sweeney; Fiscal Year: 2013
    ..This results in a lss of intestinal absorption, rapidly leading to death without parenteral nutrition (TPN)...
  32. Prenatal Alcohol Exposure Dysregulates Fetal Iron Homeostasis
    Shane M Huebner; Fiscal Year: 2013
    ..Under "normal" iron intakes alcohol enhances the intestinal absorption and liver deposition of iron, resulting in an iron overload status that exacerbates liver injury...
  33. A New Target for Kidney Stone Prevention: Calcium-Sensitive Transport of Citrate
    Kathleen S Hering-Smith; Fiscal Year: 2013
    ..3) Determine the role of NaDC1 in renal reabsorption &intestinal absorption of citrate...
  34. Drug-Dietary Flavonoid Intestinal Absorption Interaction
    ROSITA PROTEAU; Fiscal Year: 2002
    ..Thus, the results of this study will increase our understanding of the role of flavonoids found in tea, vegetables, soy, and dietary supplements in the intestinal absorption of therapeutic drugs.
  35. Roles of SLC26A6 in Renal NaCI Transport and Prevention of Oxalate Urolithiasis
    Peter S Aronson; Fiscal Year: 2013
    ..They demonstrated that the latter process is critical to limiting net intestinal absorption of oxalate and preventing hyperoxaluria and calcium oxalate urolithiasis...
  36. EFFECTS OF BILE ACIDS ON CALCIUM AND IRON ABSORPTION
    Edward Moore; Fiscal Year: 1990
    ..high-affinity binding of both Ca++ and Fe++ (and possibly Fe+++), play an important role in enhancing the intestinal absorption of these ions...
  37. SPHINGOLIPIDS AND STEROLS--METABOLISM AND INTERACTIONS
    Seiichi Matsuda; Fiscal Year: 2000
    ..and their actions on acyl coenzyme A-cholesterol acyltransferase, studies of relevance to the intestinal absorption of cholesterol and the pathogenesis of atherosclerosis...
  38. MOTILITY OF THE DIGESTIVE TRACT IN HEALTH AND DISEASE
    KEITH KELLY; Fiscal Year: 1993
    ..neurotensin and enteroglucagon, slow the rate of gastric emptying and intestinal transit and enhance intestinal absorption of liquids and solids after ileal pouch-anal anastomosis...
  39. HEPATIC DRUG ELIMINATION IN PREGNANCY
    Mary Vore; Fiscal Year: 2010
    ..MRP2 is critical for elimination of polar metabolites from liver and kidney, as well decreasing the intestinal absorption of dietary carcinogensand its expression in liver is decreasedin pregnancy...
  40. HEPATIC DRUG ELIMINATION IN PREGNANCY
    Mary Vore; Fiscal Year: 2007
    ..MRP2 is critical for elimination of polar metabolites from liver and kidney, as well decreasing the intestinal absorption of dietary carcinogens and its expression in liver is decreased in pregnancy...
  41. Absorption and Metabolism of Isoflavones
    Ming Hu; Fiscal Year: 2005
    ..form the basis for future efficacy studies to determine if improved bioavailability (through manipulating intestinal absorption and biotransformation) will translate into increased efficacy...
  42. STRUCTURE & FUNCTION OF B12 BINDING PROTEINS
    Robert Allen; Fiscal Year: 1993
    ..We will further define the ileal and neutrophil-hepatocyte mechanisms that prevent the intestinal absorption and tissue dissemination of potentially toxic Cb1 analogues of bacterial origin and determine if these Cb1 ..
  43. BREAST CANCER RISK--VEGETABLES AND SERUM PHYTOSTEROLS
    Paola Muti; Fiscal Year: 2000
    ..synthesized in human body: the phytosterols present in human blood derive solely from diet via intestinal absorption. B-sitosterol and campesterol are the predominant phytosterols in blood...
  44. DISTRIBUTION AND TRANSPORT OF LIPIDS IN MUCIN GELS
    Timothy Wiedmann; Fiscal Year: 2000
    ..The hypothesis to be tested is that the association of lipids with mucin quantitatively affects the intestinal absorption of lipids and poorly water soluble drugs...
  45. NEONATAL NUTRITION: DEVELOPMENT OF FAT ABSORPTION
    ROGER LESTER; Fiscal Year: 1991
    ..We have shown that such fundamental processes as bile acid synthesis, hepatic secretion, and intestinal absorption, are incompletely developed at birth and undergo maturation during the first weeks of life...
  46. Quantifying the impact of diet on carcinogen exposure
    JAMES FELTON; Fiscal Year: 2003
    ..carcinogens from the digestates using the human colon carcinoma cell line Caco2, a commonly used model for intestinal absorption, 3) determine the effects of single and multiple food interactions on carcinogen bioavailability in a ..
  47. ION TRANSPORT IN SMALL INTESTINE
    William Armstrong; Fiscal Year: 1991
    ..modify or regulate these transport processes, and the role of specific membrane transport processes in intestinal absorption and secretion...
  48. Microvascular Regulation During Intestinal Absorption
    HAROLD G BOHLEN; Fiscal Year: 2010
    ..A substantial fraction of the NO in blood may be from NO loading in the small arteries based on their very high wall NO concentration and represents a new form of vascular regulation. ..
  49. EVALUATION OF INTESTINAL ABSORPTION OF BETA-CAROTENE
    Sohrab Mobarhan; Fiscal Year: 1990
    ..BC VA are with various amounts of food in young and old subjects have shown that several factors influence intestinal absorption of BC...
  50. NUTRITIONAL STUDIES ON BIOTON ABSORPTION
    HAMID SAID; Fiscal Year: 1990
    ..Aging is associated with a decrease in the plasma biotin level. Since changes in intestinal absorption of certain nutrients occur with aging, we will study biotin absorption process in aged animals to ..
  51. Sitosterolemia
    Gerald Salen; Fiscal Year: 2003
    ..sitostanol and campestanol) and cholestanol accumulate in all tissues except brain because of enhanced intestinal absorption and reduced hepatic removal...
  52. NOVEL METHOD FOR INTESTINAL ABSORPTION OF ANTIBODIES
    Keith Mostov; Fiscal Year: 1999
    ....
  53. KHCO3 PREVENTS NACL INDUCED BONE RESORPTION IN HUMANS?
    Anthony Sebastian; Fiscal Year: 1999
    ..of skeletal calcium leads to homeostatic adjustments of parathyroid and vitamin D activity that increase intestinal absorption of dietary calcium...
  54. Enhancing Thrombostatin's Oral Delivery
    John Hilfinger; Fiscal Year: 2006
    ..Specific Aim #2: Evaluation of Intestinal Absorption of the Thrombostatin Analogs: The new Thrombostatin analogs will be evaluated for intestinal stability and ..
  55. IN VITRO DELIVERABILITY OF ANTI-ANTHRAX DISCOVERY LEADS
    R Porter; Fiscal Year: 2000
    ..3. Apply an in vitro (Caco-2 cells) intestinal absorption model to evaluate the deliverability of the biological active model inhibitors...
  56. Role of ABCG5 and ABCG8 in Sterol Metabolism
    Helen Hobbs; Fiscal Year: 2007
    ..sterol transport in the body have been well defined: sterols enter the body via endogenous synthesis and intestinal absorption and are excreted via the liver into the bile, either as the free sterol or after conversion to bile acids...
  57. INHIBITION OF INTESTINAL HEME IRON ABSORPTION
    JC BOMMER; Fiscal Year: 2000
    Iron overload conditions such as thalassemia and hemochromatosis result from the increased intestinal absorption of iron from inorganic iron and heme iron...
  58. SFT FUNCTION AND REGULATION IN HEMOCHROMATOSIS
    Marianne Wessling Resnick; Fiscal Year: 2003
    Hereditary hemochromatosis is a genetic disorder that promotes increased intestinal absorption and progressive tissue deposition of iron resulting in cirrhosis of the liver, hepatic carcinoma, congestive heart failure, endocrinopathies ..
  59. INTESTINAL VITAMIN A BINDING PROTEINS
    Ellen Li; Fiscal Year: 1992
    ..An understanding of the mechanisms involved in intestinal absorption of vitamin A may prove valuable in the design of oral supplementation programs...
  60. The Role of Nitric Oxide in Cholesterol Homeostasis
    Melanie Ihrig; Fiscal Year: 2003
    DESCRIPTION (provided by applicant) Cholesterol homeostasis is maintained by balancing intestinal absorption, endogenous biosynthesis, hepatic uptake and biliary secretion of cholesterol and bile acids...
  61. RESVERATROL BIOAVAILABILITY--PRECLINICAL AND CLINICAL
    Thomas Walle; Fiscal Year: 2002
    ..we are using an intermediary preclinical approach, using the Caco-2 cell line as model of human intestinal absorption as well as metabolism...
  62. UPTAKE AND ACTIONS OF GENISTEIN IN MAMMARY CANCER MODELS
    Stephen Barnes; Fiscal Year: 1999
    ..b>Intestinal absorption will be studied using everted intestinal sac preparations...
  63. Regulation of heme uptake in intestinal epithelial cells
    Aliye Uc; Fiscal Year: 2007
    ..Heme provides the majority of body's iron, but little is known about its intestinal absorption. Dr...
  64. Luminal Lipid Exposure, Genetics and Colon Cancer Risk
    Ikuko Kato; Fiscal Year: 2006
    ..We hypothesize that individuals with genotypes for lower intestinal absorption, which results in more intracolonic exposure to potentially carcinogenic substances, have a higher risk of ..
  65. INTERACTIONS AFFECTING PHENYTOIN INTESTINAL
    David Fleisher; Fiscal Year: 1991
    ..of the proposed research is to determine the extent to which coadministered glucose and calcium affect the intestinal absorption of the orally administered anticonvulsant, phenytoin, from solution...
  66. SECOND GENERATION ANTIBIOTICS FROM ETHAMBUTOL
    Marina Protopopova; Fiscal Year: 2000
    ..Medicinal chemistry will be guided by both SAR and likelihood of intestinal absorption. We propose a series of biochemical analyses that will allow us to prioritize hit molecules and confirm ..