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| intestinal absorptionSummarySummary: Uptake of substances through the lining of the INTESTINES. Top Publications
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A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation
A T McKie
Department of Molecular Medicine, King s College London, Guy s, King s, St Thomas School of Medicine, United Kingdom
Mol Cell 5:299-309. 2000..IREG1 stimulates iron efflux following expression in Xenopus oocytes. We conclude that IREG1 represents the long-sought duodenal iron export protein and is upregulated in the iron overload disease, hereditary hemochromatosis...Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption
Scott W Altmann
Department of Cardiovascular Endocrine Research, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ, 07033 0539, USA
Science 303:1201-4. 2004..Ezetimibe, a drug that inhibits cholesterol absorption, had no effect in NPC1L1 knockout mice, suggesting that NPC1L1 resides in an ezetimibe-sensitive pathway responsible for intestinal cholesterol absorption...Chylomicrons promote intestinal absorption of lipopolysaccharides
Sarbani Ghoshal
Department of Internal Medicine, Division of Digestive Diseases and Nutrition, University of Kentucky, Lexington, KY, USA
J Lipid Res 50:90-7. 2009Recent data suggest that dietary fat promotes intestinal absorption of lipopolysaccharides (LPS) from the gut microflora, which might contribute to various inflammatory disorders...The food contaminant deoxynivalenol, decreases intestinal barrier permeability and reduces claudin expression
Philippe Pinton
INRA UR66, Toulouse, France
Toxicol Appl Pharmacol 237:41-8. 2009..Considering that high levels of DON may be present in food or feed, consumption of DON-contaminated food/feed may induce intestinal damage and has consequences for human and animal health...Na(+)-D-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion
Valentin Gorboulev
Institute of Anatomy and Cell Biology, University of Wurzburg, Wurzburg, Germany
Diabetes 61:187-96. 2012..The data indicate that SGLT1 is 1) pivotal for intestinal mass absorption of d-glucose, 2) triggers the glucose-induced secretion of GIP and GLP-1, and 3) triggers the upregulation of GLUT2...Gastrointestinal persorption and tissue distribution of differently sized colloidal gold nanoparticles
J F Hillyer
Department of Animal Health and Biomedical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 1656 Linden Drive, Madison, Wisconsin 53706, USA
J Pharm Sci 90:1927-36. 2001..To our knowledge this is the first report, at the ultrastructural level, of gastrointestinal uptake of particulates by persorption through holes created by extruding enterocytes...Evaluation of the intestinal absorption of deoxynivalenol and nivalenol by an in vitro gastrointestinal model, and the binding efficacy of activated carbon and other adsorbent materials
Giuseppina Avantaggiato
CNR Institute of Sciences of Food Production ISPA, Viale Einaudi 51, I 70125 Bari, Italy
Food Chem Toxicol 42:817-24. 2004..simulating the gastrointestinal (GI) tract of healthy pigs (TIM system) was used to evaluate the small-intestinal absorption of DON and NIV and the efficacy of activated carbon in reducing the relevant absorption...Identification of an intestinal heme transporter
Majid Shayeghi
Department of Life Sciences, Nutritional Sciences Research Division, Franklin Wilkins Building, Kings College London, 150 Stamford Street, London SE1 9NN, UK
Cell 122:789-801. 2005..HCP 1 protein was iron regulated and localized to the brush-border membrane of duodenal enterocytes in iron deficiency. Our data indicate that HCP 1 is the long-sought intestinal heme transporter...Hypoxia-inducible factor-2α mediates the adaptive increase of intestinal ferroportin during iron deficiency in mice
Matthew Taylor
Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor Michigan, USA
Gastroenterology 140:2044-55. 2011..Ferroportin (FPN) is the only characterized, mammalian, basolateral iron exporter. Despite the importance of FPN in maintaining iron homeostasis, its in vivo mechanisms of regulation are unclear...HIF-2alpha, but not HIF-1alpha, promotes iron absorption in mice
Maria Mastrogiannaki
Institut Cochin, Universite Paris Descartes, CNRS, UMR, France
J Clin Invest 119:1159-66. 2009..This finding may provide a basis for the development of new strategies, specifically in targeting HIF-2alpha, to improve iron homeostasis in patients with iron disorders...Bioadhesive polysaccharide in protein delivery system: chitosan nanoparticles improve the intestinal absorption of insulin in vivo
Yan Pan
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, PR China
Int J Pharm 249:139-47. 2002..Bioadhesive polysaccharide chitosan nanoparticles (CS-NPs) would seem to further enhance intestinal absorption of them...Apical GLUT2: a major pathway of intestinal sugar absorption
George L Kellett
The University of York, Department of Biology, York YO10 5YW, UK
Diabetes 54:3056-62. 2005..These mechanisms suggest that apical GLUT2 is a potential therapeutic target for novel dietary or pharmacological approaches to control intestinal sugar delivery and thereby improve glycemic control...Cholic acid as key regulator of cholesterol synthesis, intestinal absorption and hepatic storage in mice
Charlotte Murphy
Department of Laboratory Medicine, Division of Clinical Chemistry, Karolinska University Hospital, 14186 Stockholm, Sweden
Biochim Biophys Acta 1735:167-75. 2005..The possibility is discussed that inhibition of CYP8B1 and thus CA synthesis may be beneficial for the treatment of hyperlipidemic disorders...Microbiota regulate intestinal absorption and metabolism of fatty acids in the zebrafish
Ivana Semova
Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Cell Host Microbe 12:277-88. 2012..While intestinal microbiota clearly impact the host's energy balance, their role in intestinal absorption and extraintestinal metabolism of dietary fat is less clear...Phosphate homeostasis and the renal-gastrointestinal axis
Joanne Marks
Dept of Neuroscience, Physiology, and Pharmacology, Univ College London Medical School, UK
Am J Physiol Renal Physiol 299:F285-96. 2010....Deoxynivalenol transport across human intestinal Caco-2 cells and its effects on cellular metabolism at realistic intestinal concentrations
Thérèse Sergent
Laboratoire de Biochimie Cellulaire, Croix du Sud, 5, Institut des Sciences de la Vie and Université Catholique de Louvain, B 1348 Louvain la Neuve, Belgium
Toxicol Lett 164:167-76. 2006..These data imply that a chronic exposure to DON contaminated foods may negatively affect human health by altering the intestinal mucosa integrity and by inducing the MAPKs implicated in inflammation...The mycotoxin deoxynivalenol affects nutrient absorption in human intestinal epithelial cells
Marc Maresca
Institut Méditerranéen de Recherche en Nutrition, Unité Mixte de Recherche Institut National de la Recherche Agronomique, Faculté des Sciences de Saint Jérôme, Marseille, France
J Nutr 132:2723-31. 2002....Chitosan nanoparticles enhance the intestinal absorption of the green tea catechins (+)-catechin and (-)-epigallocatechin gallate
Admire Dube
Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University Parkville Campus, 381 Royal Parade, Parkville, Victoria, Australia
Eur J Pharm Sci 41:219-25. 2010..their therapeutic potential is limited by their low oral bioavailability, attributed to poor stability and intestinal absorption. We encapsulated (+)-catechin (C) and (-)-epigallocatechin gallate (EGCg) in chitosan nanoparticles (CS NP)..Thiolated carboxymethylcellulose: in vitro evaluation of its permeation enhancing effect on peptide drugs
A E Clausen
Centre of Pharmacy, Institute of Pharmaceutical Technology and Biopharmaceutics, University of, Vienna, Austria
Eur J Pharm Biopharm 51:25-32. 2001....Prediction of intestinal permeability
William J Egan
Accelrys Inc, ADMET R and D, CN 5350, Princeton, NJ 08543 5350, USA
Adv Drug Deliv Rev 54:273-89. 2002..e. data quantity, measurement imprecision, confounding factors such as solubility, metabolism, or active efflux, and the need for robust statistical methods, are also discussed...Intestinal lipid absorption
Jahangir Iqbal
Dept of Anatomy, 450 Clarkson Ave, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
Am J Physiol Endocrinol Metab 296:E1183-94. 2009....Postprandial changes in small bowel water content in healthy subjects and patients with irritable bowel syndrome
Luca Marciani
Nottingham Digestive Diseases Centre NIHR Biomedical Research Unit, Queen s Medical Centre Campus, Nottingham University Hospitals NHS Trust, University of Nottingham, Nottingham, United Kingdom
Gastroenterology 138:469-77, 477.e1. 2010..We studied postprandial changes in distribution of water in the upper gastrointestinal tract of healthy volunteers (HVs) and patients with IBS-D after contrasting meals...MDCK (Madin-Darby canine kidney) cells: A tool for membrane permeability screening
J D Irvine
Affymax Research Institute A Glaxo Wellcome Company, Santa Clara, California 95051
J Pharm Sci 88:28-33. 1999..58 compared with 0.54 for Caco-2 Papp and human absorption. These results indicate that MDCK cells may be a useful tool for rapid membrane permeability screening...Green tea as inhibitor of the intestinal absorption of lipids: potential mechanism for its lipid-lowering effect
Sung I Koo
Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269 4017, USA
J Nutr Biochem 18:179-83. 2007..to be determined, it is evident from in vitro and in vivo studies that green tea or catechins inhibit the intestinal absorption of dietary lipids...Membrane transporters and folate homeostasis: intestinal absorption and transport into systemic compartments and tissues
Rongbao Zhao
Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Expert Rev Mol Med 11:e4. 2009..This review focuses on the physiological roles of the major folate transporters, with a brief consideration of their impact on the pharmacological activities of antifolates...Methylation of dietary flavones greatly improves their hepatic metabolic stability and intestinal absorption
Thomas Walle
Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Mol Pharm 4:826-32. 2007..Thus, methylation appears to be a simple and effective way of increasing both metabolic resistance and transport of the flavonoids and, most important, some of their major biological activities...Gelatin coated hybrid lipid nanoparticles for oral delivery of amphotericin B
Sanyog Jain
Centre for Pharmaceutical Nanotechnology, Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Sector 67, SAS Nagar Mohali, Punjab 160062, India
Mol Pharm 9:2542-53. 2012..The histopathology of the kidney tissues further confirmed the absence of any changes in the morphology of the renal tubules...Review article: fructose malabsorption and the bigger picture
P R Gibson
Department of Gastroenterology and Monash University Department of Medicine, Box Hill Hospital, Victoria, Australia
Aliment Pharmacol Ther 25:349-63. 2007....The fraction dose absorbed, in humans, and high jejunal human permeability relationship
Arik Dahan
Department of Clinical Pharmacology, School of Pharmacy, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
Mol Pharm 9:1847-51. 2012..In this situation, the use of multiple permeability experimental methods, including the use of metabolism, which except for luminal degradation requires absorption, is prudent and encouraged...Intestinal physiology and peptidase activity in male pigs are modulated by consumption of corn culture extracts containing fumonisins
Martin Lessard
Institut National de la Recherche Agronomique Unité Mixte de Recherche 1039, Systèmes d Elevage, Nutrition Animale et Humaine, F 35590 Saint Gilles, France
J Nutr 139:1303-7. 2009..In conclusion, consumption of an extract rich in fumonisins for 9 d has the potential to alter intestinal physiology, villous architecture, and enzyme activities. Underlying mechanisms remain to be investigated...Fructose malabsorption and symptoms of irritable bowel syndrome: guidelines for effective dietary management
Susan J Shepherd
Department of Gastroenterology and Monash University, Victoria, Australia
J Am Diet Assoc 106:1631-9. 2006..01), as was improvement in individual symptoms (P<0.01 for all symptoms). This comprehensive fructose malabsorption dietary therapy achieves a high level of sustained adherence and good symptomatic response...Pharmacology, efficacy and safety of oral phosphate binders
Alastair J Hutchison
Manchester Biomedical Research Centre, Manchester Royal Infirmary Renal Unit, Oxford Road, Manchester M13 9WL, UK
Nat Rev Nephrol 7:578-89. 2011..Without such a study we will continue to rely on observational data with all its uncertainties and potential to mislead...In vitro study of transporters involved in intestinal absorption of inorganic arsenic
Marta Calatayud
Instituto de Agroquimica y Tecnologia de Alimentos CSIC, Av Agustín Escardino, 7, 46980 Paterna, Valencia, Spain
Chem Res Toxicol 25:446-53. 2012..anion transporting polypeptides (OATPs), aquaporins (AQPs), and phosphate transporters (NaPi and PiT)] in intestinal absorption of As(V) and As(III), using the Caco-2 cell line as a model of the intestinal epithelium...Emerging trends in oral delivery of peptide and protein drugs
Ram I Mahato
Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
Crit Rev Ther Drug Carrier Syst 20:153-214. 2003..The roles of P-glycoprotein and CYP3A4 in controlling the extent of intestinal absorption and metabolism will also be discussed.Simple-sugar meals target GLUT2 at enterocyte apical membranes to improve sugar absorption: a study in GLUT2-null mice
F Gouyon
INSERM U505, UPMC, Paris, France
J Physiol 552:823-32. 2003..We also observe that a large improvement of intestinal absorption is promoted by the transient recruitment of food-facing GLUT2, induced by the ingestion of a simple-sugar ..Compensatory increase in hepatic lipogenesis in mice with conditional intestine-specific Mttp deficiency
Yan Xie
Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Biol Chem 281:4075-86. 2006..These findings establish distinctive features for MTTP involvement in intestinal chylomicron assembly and secretion and suggest that hepatic lipogenesis undergoes compensatory induction in the face of defective intestinal TG secretion...The intestine as a possible target for fumonisin toxicity
Sandrine Bouhet
Laboratoire de Pharmacologie Toxicologie, INRA, Toulouse, France
Mol Nutr Food Res 51:925-31. 2007....Role of the intestinal tight junction modulator zonulin in the pathogenesis of type I diabetes in BB diabetic-prone rats
Tammara Watts
Mucosal Biology Research Center and Division of Pediatric Gastroenterology and Nutrition, and Division of Pediatric Research, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Proc Natl Acad Sci U S A 102:2916-21. 2005..Combined together, these findings suggest that the zonulin-induced loss in small intestinal barrier function is involved in the pathogenesis of T1D in the BB diabetic-prone animal model...PPARalpha-mediated effects of dietary lipids on intestinal barrier gene expression
Heleen M de Vogel-van den Bosch
Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, PO Box 8129, NL 6700EV, Wageningen, The Netherlands
BMC Genomics 9:231. 2008..To this end we used triacylglycerols composed of identical fatty acids in combination with gene expression profiling in wild-type and PPARalpha-null mice. Treatment with the synthetic PPARalpha agonist WY14643 served as reference...Inhibitory effect of calcium on non-heme iron absorption may be related to translocation of DMT-1 at the apical membrane of enterocytes
Ben A V Thompson
School of Medicine, University of East Anglia, Norwich NR4 7TJ, UK
J Agric Food Chem 58:8414-7. 2010..No change was seen in ferroportin expression. Our data suggest that calcium reduces iron bioavailability by decreasing DMT-1 expression at the apical cell membrane, thereby downregulating iron transport into the cell...Enabling the intestinal absorption of highly polar antiviral agents: ion-pair facilitated membrane permeation of zanamivir heptyl ester and guanidino oseltamivir
Jonathan M Miller
Center for Molecular Drug Targeting, Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, USA
Mol Pharm 7:1223-34. 2010..The goal of this work was to enhance the intestinal absorption of the low-permeability antiviral agents zanamivir heptyl ester (ZHE) and guanidino oseltamivir (GO) ..Conditional Gata4 deletion in mice induces bile acid absorption in the proximal small intestine
Eva Beuling
GI Cell Biology, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
Gut 59:888-95. 2010....Genetic polymorphisms of OATP transporters and their impact on intestinal absorption and hepatic disposition of drugs
Takeo Nakanishi
Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Pharmacy, Kanazawa University, Kanazawa, Japan
Drug Metab Pharmacokinet 27:106-21. 2012..and OATP1B3 contributes to the hepatic uptake of drugs from the portal vein, and OATP2B1 may alter their intestinal absorption as well as hepatic extraction...The digestive adaptation of flying vertebrates: high intestinal paracellular absorption compensates for smaller guts
Enrique Caviedes-Vidal
Laboratorio de Biología Prof E Caviedes Codelia, Facultad de Ciencias Humanas, and Departamento de Bioquímica y Ciencias Biológicas, Universidad Nacional de San Luís Consejo Nacional de Investigaciones Científicas y Técnicas, 5700 San Luis, Argentina
Proc Natl Acad Sci U S A 104:19132-7. 2007..Here, we further show that an enhanced paracellular pathway for intestinal absorption of water-soluble nutrients such as glucose and amino acids may compensate for reduced small intestines in ..Intestinal absorption and first-pass metabolism of polyphenol compounds in rat and their transport dynamics in Caco-2 cells
Zenghui Teng
Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi an, People s Republic of China
PLoS ONE 7:e29647. 2012..The relationship between their chemical structure and intestinal absorption, transport, and first-pass metabolism remains unresolved, however.Helodermin-loaded nanoparticles: characterization and transport across an in vitro model of the follicle-associated epithelium
Anne des Rieux
Unite de Pharmacie Galenique, Universite Catholique de Louvain, Brussels, Belgium
J Control Release 118:294-302. 2007..Transport of free and encapsulated helodermin occurred most probably by endocytosis. In conclusion, M cells improved helodermin transport across the intestinal epithelium, confirming their high potential for oral delivery of peptides...An iron-regulated ferric reductase associated with the absorption of dietary iron
A T McKie
Department of Molecular Medicine, Guy s, King s and St Thomas School of Medicine, King s College London, Rayne Institute, Denmark Hill Campus, 123 Coldharbour Lane, London SE5 9NU, UK
Science 291:1755-9. 2001..Duodenal expression levels of Dcytb messenger RNA and protein were regulated by changes in physiological modulators of iron absorption. Thus, Dcytb provides an important element in the iron absorption pathway...Seasonal variation in amount of unabsorbed dietary carbohydrate from the intestine after breakfast in young female Thai subjects: comparison with that of Japanese subjects
Yuki Tsumura
Department of Food and Nutrition Studies, Junshin Junior College, Thailand
J Physiol Anthropol 29:141-7. 2010..These results suggest that differences in seasonal change in a living environment have different effects on seasonal variations in the efficiency of carbohydrate absorption in the intestine after breakfast...Fatty acid- and cholesterol transporter protein expression along the human intestinal tract
Christiaan J Masson
Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
PLoS ONE 5:e10380. 2010..Protein distribution profiles along the human intestinal tract of transporters involved in the absorption of cholesterol and long-chain fatty acids (LCFA) have been scarcely evaluated...Influence of class B scavenger receptors on cholesterol flux across the brush border membrane and intestinal absorption
David V Nguyen
Gastroenterology, Hepatology, and Nutrition Division, Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4318, USA
J Lipid Res 50:2235-44. 2009....Efficacy and tolerability of Creon for Children in infants and toddlers with pancreatic exocrine insufficiency caused by cystic fibrosis: an open-label, single-arm, multicenter study
Carla Colombo
CF Center of Milano, Fondazione IRCCS Ospedale Policlinico, Mangiagalli, Regina Elena, Milano, and University of Milan, Milan, Italy
Pancreas 38:693-9. 2009..To evaluate the efficacy and safety of a pancreatic enzyme preparation specifically developed for infants and small children with cystic fibrosis (CF)...Low bioavailability of dietary epoxyxanthophylls in humans
Akira Asai
National Food Research Institute, NARO, 2 1 12 Kannondai, Tsukuba, Ibaraki 305 8642, Japan
Br J Nutr 100:273-7. 2008..However, there is little information about the intestinal absorption and metabolic fate of dietary epoxyxanthophylls in humans...ATP-binding cassette transporter A1 is significantly involved in the intestinal absorption of alpha- and gamma-tocopherol but not in that of retinyl palmitate in mice
Emmanuelle Reboul
INRA, UMR1260, Nutriments Lipidiques et Prévention des Maladies Métaboliques, INSERM, U476, Université Aix Marseille 1, Université Aix Marseille 2, Faculte de Medecine, IPHM IFR 125, Marseille, France
Am J Clin Nutr 89:177-84. 2009..It has long been assumed that newly absorbed vitamin A and E enter the body only via enterocyte-produced chylomicrons. However, recent results in cell cultures have shown that a fraction of alpha-tocopherol is secreted with intestinal HDL...ISX is a retinoic acid-sensitive gatekeeper that controls intestinal beta,beta-carotene absorption and vitamin A production
Glenn P Lobo
Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44160, USA
FASEB J 24:1656-66. 2010..The role of SR-BI in the intestinal absorption of other dietary lipids, including cholesterol, fatty acids, and tocopherols, implicates retinoid ..Predicting the impact of physiological and biochemical processes on oral drug bioavailability
B Agoram
Simulations Plus, Inc. 1220 W. Avenue J, Lancaster, CA 93534-2902, USA
Adv Drug Deliv Rev 50:S41-67. 2001..time profiles for common drugs and compare those estimates to literature data. We illustrate the simulated impact of physiological and biochemical processes on oral drug bioavailability...Intestinal ferritin H is required for an accurate control of iron absorption
Liviu Vanoaica
ISREC Swiss Institute for Experimental Cancer Research, Lausanne, Switzerland
Cell Metab 12:273-82. 2010..Our results demonstrate that hepcidin-mediated regulation alone is insufficient to restrict iron absorption and that intestinal ferritin H is also required to limit iron efflux from intestinal cells...Intestinal absorption enhancement via the paracellular route by fatty acids, chitosans and others: a target for drug delivery
María José Cano-Cebrián
Departamento de Farmacia y Tecnologia Farmaceutica, Facultad de Farmacia, Universidad de Valencia, Burjassot Valencia, Spain
Curr Drug Deliv 2:9-22. 2005..The few studies performed in vivo are also presented. In addition, the findings of recent absorption enhancers, such as zonula occludens toxin or thiolated polymers, are reviewed...Permeability, zonulin production, and enteropathy in dermatitis herpetiformis
Edgardo Smecuol
Dr C Bonorino Udaondo Gastroenterology Hospital, Av Caseros 2061, 1264 Buenos Aires, Argentina
Clin Gastroenterol Hepatol 3:335-41. 2005..Our aim was to assess both intestinal permeability and serum zonulin levels in a group of patients with DH having variable grades of enteropathy...Tight junction modulation and its relationship to drug delivery
Noha N Salama
Pharmacokinetics Biopharmaceutics Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland at Baltimore, 100 Penn Street, Baltimore, Maryland 21201, USA
Adv Drug Deliv Rev 58:15-28. 2006..Above all, the transient opening of the TJs by Zot suggests that it could be used as a novel approach for the safe drug delivery of therapeutic agents...Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers
Ina Hubatsch
Department of Pharmacy, Uppsala University, Uppsala, Sweden
Nat Protoc 2:2111-9. 2007..The permeability assay can be completed within one working day, provided that the Caco-2 monolayers have been cultured and differentiated on the permeable supports 3 weeks in advance...Absorption, metabolism and excretion of 3-acetyl DON in pigs
G S Eriksen
Department of Animal Nutrition and Management, Swedish University of Agricultural Sciences, Uppsala, Sweden
Arch Tierernahr 57:335-45. 2003..Furthermore, the experiment shows that the main part of DON is rapidly excreted and does not accumulate in plasma, but a minor part of the toxin is retained and slowly excreted from the pigs...Intestinal lymphatic drug transport: an update
C J Porter
Department of Pharmaceutics, Victorian College of Pharmacy, Monash University Parkville Campus, 381 Royal Parade, Parkville, Victoria 3052, Australia
Adv Drug Deliv Rev 50:61-80. 2001..Finally the possible future directions for studies of intestinal lymphatic transport are discussed, including the use of cell culture models and genetically modified animals...Modulation of intestinal P-glycoprotein function by cremophor EL and other surfactants by an in vitro diffusion chamber method using the isolated rat intestinal membranes
Yasushi Shono
Department of Biopharmaceutics, Kyoto Pharmaceutical University, Misasagi Yamashina ku, Kyoto 607 8414 Japan
J Pharm Sci 93:877-85. 2004..suggested that charge of surfactants was possibly related to the action of these surfactants on the intestinal absorption of P-gp substrates...Oral delivery of peptide drugs: barriers and developments
Josias H Hamman
School of Pharmacy, Tshwane University of Technology, Pretoria, South Africa
BioDrugs 19:165-77. 2005..A considerable amount of research has focused on overcoming the challenges presented by these intestinal absorption barriers to provide effective oral delivery of peptide and protein drugs...Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study
Luigi Ferrucci
Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, United States of America
Am J Hum Genet 84:123-33. 2009..002). Our findings might shed light on the controversial relationship between lipid-soluble anti-oxidant nutrients and human health...Lipid-based delivery systems for improving the bioavailability and lymphatic transport of a poorly water-soluble LTB4 inhibitor
D J Hauss
Department of Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, Connecticut 06877 0368, USA
J Pharm Sci 87:164-9. 1998....On the toxicokinetics and the metabolism of deoxynivalenol (DON) in the pig
S Danicke
Institute of Animal Nutrition, Federal Agricultural Research Centre FAL Braunschweig, Germany
Arch Anim Nutr 58:169-80. 2004..It was concluded that de-epoxydation of DON, which primarily occurs in the hindgut, probably does not contribute much to a detoxification in the pig...The mycotoxin ochratoxin A alters intestinal barrier and absorption functions but has no effect on chloride secretion
M Maresca
, , 13397 Marseille Cedex 20, France
Toxicol Appl Pharmacol 176:54-63. 2001..Taken together, these data showed that OTA alters both barrier and absorption functions of the intestinal epithelium...Cholesterol absorption is mainly regulated by the jejunal and ileal ATP-binding cassette sterol efflux transporters Abcg5 and Abcg8 in mice
Li ping Duan
Department of Medicine, Liver Center and Gastroenterology Division, Beth Israel Deaconess Medical Center, Harvard Medical School and Harvard Digestive Diseases Center, 330 Brookline Avenue, DA 601, Boston, MA 02215, USA
J Lipid Res 45:1312-23. 2004..We conclude that Ch absorption is mainly regulated by the jejunal and ileal Abcg5 and Abcg8 in mice...Absorption of fumonisin B1 and aminopentol on an in vitro model of intestinal epithelium; the role of P-glycoprotein
I De Angelis
Department of Environment and Primary Prevention, Toxicity Mechanism Unit, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
Toxicon 45:285-91. 2005....Intestinal absorption of dietary cholesteryl ester is decreased but retinyl ester absorption is normal in carboxyl ester lipase knockout mice
W Weng
Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York 10021, USA
Biochemistry 38:4143-9. 1999..Other suggested roles for CEL include the direct facilitation of the intestinal absorption of free cholesterol and the modification of plasma lipoproteins...High cholesterol absorption efficiency and rapid biliary secretion of chylomicron remnant cholesterol enhance cholelithogenesis in gallstone-susceptible mice
David Q H Wang
Department of Medicine, Harvard Medical School and Harvard Digestive Diseases Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
Biochim Biophys Acta 1733:90-9. 2005..Differential metabolism of the chylomicron remnant cholesterol between C57L and AKR mice clearly plays a crucial role in the formation of lithogenic bile and gallstones...Diet-derived advanced glycation end products are major contributors to the body's AGE pool and induce inflammation in healthy subjects
Jaime Uribarri
Division of Nephrology, Deparment of Medicine, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
Ann N Y Acad Sci 1043:461-6. 2005..Together with previous evidence from diabetics and renal failure patients, these data suggest that dietary AGEs may play an important role in the causation of chronic diseases associated with underlying inflammation...Intestinal absorption of dietary carotenoids
Lina Yonekura
National Food Research Institute, Tsukuba, Ibaraki, Japan
Mol Nutr Food Res 51:107-15. 2007..Comparisons between the intestinal absorption of a wide array of carotenoids would be useful to elucidate the absorption mechanism of each carotenoid ..CD36 mediates both cellular uptake of very long chain fatty acids and their intestinal absorption in mice
Victor A Drover
Department of Pharmacology, State University of New York, Stony Brook, New York 11794, USA
J Biol Chem 283:13108-15. 2008..Together, these findings represent the first direct evidence for protein-facilitated FA absorption in the intestine and identify a novel therapeutic target for the treatment of diseases characterized by elevated VLCFA levels...Nanoparticles as potential oral delivery systems of proteins and vaccines: a mechanistic approach
Anne des Rieux
Universite Catholique de Louvain, Unite de Pharmacie Galenique, avenue E Mounier, 73 20, 1200 Brussels, Belgium
J Control Release 116:1-27. 2006..Encouraging results upon in vivo testing are reported but low bioavailability and lack of control on absorbed dose slow down products development. Vaccines are certainly the most promising applications for orally delivered nanoparticles...Dietary polyphenols decrease glucose uptake by human intestinal Caco-2 cells
Kelly Johnston
Centre for Nutrition and Food Safety, School of Biomedical and Molecular Sciences, University of Surrey, Guildford, Surrey GU2 7XH, UK
FEBS Lett 579:1653-7. 2005..The non-glycosylated dietary polyphenols appear to exert their effects via steric hindrance, and (-)-epigallochatechingallate, (-)-epichatechingallate and (-)-epigallochatechin are effective against both transporters...Docetaxel microemulsion for enhanced oral bioavailability: preparation and in vitro and in vivo evaluation
Yong Mei Yin
College of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China
J Control Release 140:86-94. 2009..These results encourage further development of docetaxel microemulsions as an oral drug delivery system...Molecular cloning and characterization of a channel-like transporter mediating intestinal calcium absorption
J B Peng
Membrane Biology Program, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 274:22739-46. 1999..Our studies strongly suggest that CaT1 provides the principal mechanism for Ca(2+) entry into enterocytes as part of the transcellular pathway of calcium absorption in the intestine...P-glycoprotein inhibitors and their screening: a perspective from bioavailability enhancement
Manthena V S Varma
Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Phase X, Sector 67, 160062 Punjab, SAS Nagar, India
Pharmacol Res 48:347-59. 2003..Inhibition of P-glycoprotein improves intestinal absorption and tissue distribution while reducing the substrate metabolism and its elimination...A novel, noninvasive method for the measurement of intestinal fat absorption
Ronald J Jandacek
University of Cincinnati, College of Medicine, Department of Pathology, Ohio 45267, USA
Gastroenterology 127:139-44. 2004..The goal of the study was to facilitate fat balance measurements with an appropriate intestinal marker for the transit of dietary fat and thereby eliminate the need for complete diet and fecal collections...Reducing small intestinal permeability attenuates colitis in the IL10 gene-deficient mouse
M C Arrieta
Department of Medicine, University of Alberta, Walter C Mackenzie Health Science Ctre, Edmonton, AB, Canada
Gut 58:41-8. 2009..Furthermore, the development of colitis is dependent upon luminal agents, as animals do not develop disease if raised under germ-free conditions...Carotenoid bioavailability and bioconversion
Kyung Jin Yeum
Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
Annu Rev Nutr 22:483-504. 2002....Physiology and molecular biology of dietary iron absorption
Silvia Miret
Department of Life Sciences, King s College London, The Franklin Wilkins Building, London
Annu Rev Nutr 23:283-301. 2003Characterization of water-in-oil microemulsion for oral delivery of earthworm fibrinolytic enzyme
Mao Bo Cheng
Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China
J Control Release 129:41-8. 2008..These findings indicated that the w/o microemulsion may represent a safe and effective oral delivery system for hydrophilic bioactivity macromolecules...The cholesterol absorption inhibitor ezetimibe acts by blocking the sterol-induced internalization of NPC1L1
Liang Ge
State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Cell Metab 7:508-19. 2008..Together, our data suggest a model wherein cholesterol is internalized into cells with NPC1L1 through clathrin/AP2-mediated endocytosis and ezetimibe inhibits cholesterol absorption by blocking the internalization of NPC1L1...Mechanisms underlying saturable intestinal absorption of metformin
William R Proctor
Division of Molecular Pharmaceutics, Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Drug Metab Dispos 36:1650-8. 2008..This report provides strong evidence for a saturable mechanism in the paracellular space and provides insight into possible mechanisms for the dose dependence of metformin absorption in vivo...DGAT1 is not essential for intestinal triacylglycerol absorption or chylomicron synthesis
Kimberly K Buhman
Gladstone Institute of Cardiovascular Disease, San Francisco, California 94141 9100, USA
J Biol Chem 277:25474-9. 2002..Our findings indicate that multiple mechanisms for triacylglycerol synthesis in the intestine facilitate triacylglycerol absorption...Uncoupling of intestinal mitochondrial oxidative phosphorylation and inhibition of cyclooxygenase are required for the development of NSAID-enteropathy in the rat
S Somasundaram
Departments of Medicine and Surgery, Guy s, King s and St Thomas Medical School, Camberwell, UK
Aliment Pharmacol Ther 14:639-50. 2000..One suggestion is that the nonprostaglandin mechanism involves uncoupling of mitochondrial oxidative phosphorylation...Selective sterol accumulation in ABCG5/ABCG8-deficient mice
Liqing Yu
McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
J Lipid Res 45:301-7. 2004The ATP binding cassette (ABC) transporters ABCG5 and ABCG8 limit intestinal absorption and promote biliary secretion of neutral sterols...How should we assess the effects of exposure to dietary polyphenols in vitro?
Paul A Kroon
Nutrition Division, Institute of Food Research, Norwich, United Kingdom
Am J Clin Nutr 80:15-21. 2004..1-10 micromol/L. For correct interpretation of results, future efforts to define biological activities of polyphenols must make use of the available data concerning bioavailability and metabolism in humans...Augmented increase in tight junction permeability by luminal stimuli in the non-inflamed ileum of Crohn's disease
J D Soderholm
Department of Surgery and Clinical Research Centre, University Hospital, Linkoping, Sweden
Gut 50:307-13. 2002..The luminal contents are important for development of neoinflammation following resection. Regulation of tight junctions by luminal factors has not previously been studied in Crohn's disease...Intestinal permeability and irritable bowel syndrome
M Camilleri
Clinical Enteric Neuroscience Translational and Epidemiological Research Group, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Neurogastroenterol Motil 19:545-52. 2007....Cholesterol absorption efficiency and sterol metabolism in obesity
T A Miettinen
Department of Medicine, Division of Internal Medicine, University of Helsinki, P O Box 340, FIN 00029 HYKS, Helsinki, Finland
Atherosclerosis 153:241-8. 2000..These mechanisms could have contributed to changes in metabolism of non-cholesterol sterols, especially of cholestanol and plant sterols...Current strategies used to enhance the paracellular transport of therapeutic polypeptides across the intestinal epithelium
Nazila Salamat-Miller
Division of Pharmaceutical Sciences, Room 211A, School of Pharmacy, University of Missouri Kansas City, Kansas City, MO 64110 2499, USA
Int J Pharm 294:201-16. 2005....Protein drug oral delivery: the recent progress
Hye J Lee
College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Kwanak gu, Korea
Arch Pharm Res 25:572-84. 2002..This review provides a summary of the novel approaches currently in progress in the protein oral delivery followed by factors affecting protein oral absorption...Effects of probiotic therapy in critically ill patients: a randomized, double-blind, placebo-controlled trial
Cathy Alberda
Royal Alexandra Hospital, Edmonton, Canada, University of Alberta, Edmonton, Canada
Am J Clin Nutr 85:816-23. 2007..A breakdown in gut barrier function and immune dysfunction are associated with the onset of MODS. Probiotic bacteria have been shown to modulate intestinal barrier and immune function...Microemulsion formulation for enhanced absorption of poorly soluble drugs. II. In vivo study
Kohsaku Kawakami
Developmental Research Laboratories, Shionogi and Co, Ltd, 12 4 Sagisu 5 chome, Fukushima ku, 553 0002, Osaka, Japan
J Control Release 81:75-82. 2002..HCO-60 and Tween 80-based formulations were mild to the organs, while BL-9EX-based formulation caused serious damage. The behavior and absorption mechanism of the microemulsion formulations are discussed...Dietary oxidized n-3 PUFA induce oxidative stress and inflammation: role of intestinal absorption of 4-HHE and reactivity in intestinal cells
Manar Awada
INRA, U1235 CarMeN laboratory, F 69621 Villeurbanne, France
J Lipid Res 53:2069-80. 2012..We therefore studied such effects and hypothesized the involvement of the intestinal absorption of 4-hydroxy-2-hexenal (4-HHE), an oxidized n-3 PUFA end-product...Prediction of intestinal first-pass drug metabolism
Jiansong Yang
Simcyp Limited, Blades Enterprise Centre, Sheffield, UK
Curr Drug Metab 8:676-84. 2007..The former overpredicts the fraction escaping first-pass gut metabolism; the latter improves the predictions by accounting for interplay between permeability and metabolism...Deoxynivalenol affects in vitro intestinal epithelial cell barrier integrity through inhibition of protein synthesis
Jacqueline Van De Walle
Institut des Sciences de la Vie and UCLouvain, B 1348 Louvain la Neuve, Belgium
Toxicol Appl Pharmacol 245:291-8. 2010....
Research Grants
- Regulation of Bile Acid Synthesis by Nuclear Receptors in VivoGregorio Gil; Fiscal Year: 2012Bile acids are required for intestinal absorption and biliary solubilization of cholesterol and lipids. In addition, bile acids play a crucial role in cholesterol homeostasis...
- Functions of the Human OST-alpha and OST-beta ProteinsPatricia M Hinkle; Fiscal Year: 2013..Because the enterohepatic circulation of bile acids is essential for processes such as intestinal absorption of dietary fats and vitamins, cholesterol homeostasis, bile flow, and biliary lipid secretion, these data ..
- 2011 Mechanisms of Membrane Transport Gordon Research ConferenceNancy Carrasco; Fiscal Year: 2011..to human health: transporters and channels are key elements in renal regulation of serum ion levels, intestinal absorption of nutrients, and neuronal modulation of signaling, among a host of other processes...
- Molecular Components Affecting Ocular Retinoid HomeostasisJOHANNES FRIEDERICH VONLINTIG; Fiscal Year: 2012..objective of the proposed studies is to analyze two key steps affecting ocular retinoid metabolism: the intestinal absorption and metabolic conversion of b,b-carotene to retinol and the uptake of b,b-carotene-derived retinol into ..
- Transferrin Conjugates for Oral Protein Drug DeliveryWei Chiang Shen; Fiscal Year: 2013..Although the feasibility of TfR- mediated intestinal absorption of protein drugs has been demonstrated in our and others'laboratories, the in vivo modification of ..
- Structural Biology of the Apical Bile Acid Transporter.Peter W Swaan; Fiscal Year: 2012..PUBLIC HEALTH RELEVANCE: Bile acids play an invaluable role in the intestinal absorption of food-derived lipids and lipid-soluble vitamins and drugs...
- Divalent metal-ion transporter DMT1 and its role in intestinal metal-ion uptakeBryan Mackenzie; Fiscal Year: 2012..provided by applicant): DMT1 is a widely-expressed iron transporter that is essential for adequate intestinal absorption of iron and for transport of iron in red blood cell precursors for the production of hemoglobin...
- EPITHELIAL OXALATE AND CITRATE TRANSPORTDAVID BRUCE MOUNT; Fiscal Year: 2011..The intestinal absorption of oxalate may in turn be a major determinant of its excretion in the urine and the natural history of ..
- Mechanism/Regulation of Intestinal Thiamin UptakeHamid M Said; Fiscal Year: 2013..application is to continue our investigations into the cellular and molecular mechanisms involved in the intestinal absorption process of the water- soluble vitamin B1 (thiamin) and their regulation...
- Ligand independent signaling by VDR in KeratinocytesPaul N MacDonald; Fiscal Year: 2010..1,25-dihydroxyvitamin D3 (1,25(OH)2D3) is to maintain appropriate calcium homeostasis by ensuring adequate intestinal absorption of dietary calcium...
- Proton-coupled folate/antifolate transportISRAEL DAVID GOLDMAN; Fiscal Year: 2013..From a physiological perspective, PCFT plays a critical role in intestinal absorption of folates and the maintenance of folate sufficiency...
- Intestinal Vitamin B2 Absorption: Molecular/Cellular Aspects and Effects of AlcohHamid M Said; Fiscal Year: 2013..of this application are to characterize the molecular mechanisms involved in the regulation of the intestinal absorption of vitamin B2 (riboflavin, RF), and those involved in intracellular trafficking and membrane targeting of ..
- Oral prodrug of a novel antiviral that blocks neuronal reactivation of HSVGeorge E Wright; Fiscal Year: 2012..formulate the pro-drug Sacrovir (6-deoxy-mCF3PG) to enhance its intestinal absorption;strategies include emulsions, small molecule adjuvants, and solubility enhancers;2...
- Drosophila model of oxalate nephrolithiasisMichael F Romero; Fiscal Year: 2013..Slc26a6 is an electrogenic Cl-/ox2- exchanger involved in both intestinal absorption and renal excretion of oxalate. Slc26a6 knockout mice develop hyperoxaluria and CaOx stones...
- Oral paclitaxel solubilized and bioenhanced by food compound for cancer therapyZhijun Liu; Fiscal Year: 2013..NANO-PTX attained a permeability coefficient that predicts 65% intestinal absorption whereas the naked PTX is nearly impermeable...
- Intestinal Biotin Absorption: Physiological, Cellular and Molecular AspectsHamid M Said; Fiscal Year: 2013..application is to continue our investigations into the physiology and cell/molecular biology of the intestinal absorption process of the water-soluble vitamin biotin...
- Role of Rab proteins in hSVCT1 cell biology in intestinal epithelial cellsVeedamali S Subramanian; Fiscal Year: 2010..C is an essential nutrient for human well-being and cannot be synthesized, obtains it from diet via intestinal absorption. Human intestine plays a role in regulating and maintaining body vitamin C homeostasis, studies on the ..
- Cranberry: Interactions with Anti-infectious AgentsGail Anderson; Fiscal Year: 2005..e., intestinal) drug transporter function. The intestinal absorption of many beta-lactam antibiotics is mediated by peptide transporters (e.g. PepT1) and possibly OATP...
- Mechanisms Regulating Non-biliary Fecal Sterol LossJonathan Mark Brown; Fiscal Year: 2010..It is generally accepted that cholesterol enters the body via intestinal absorption or endogenous synthesis, and is excreted out of the body via a hepatobiliary route, either as free sterol ..
- Absorption, Metabolism and Biodistribution of Prions after Oral IngestionClaudio Soto; Fiscal Year: 2013..manner the initial fate of prions upon oral exposure, including the estimation of gut metabolism, intestinal absorption, excretion, whole body tissue distribution, and brain uptake...
- BIOCHEMISTRY OF PROTEIN PRENYLATIONChristophe L M J Verlinde; Fiscal Year: 2012..In vitro assessment of drug metabolism and intestinal absorption will be used to screen potent PFT inhibitors...
- Mechanisms Regulating Non-biliary Fecal Sterol LossJonathan Mark Brown; Fiscal Year: 2013..It is generally accepted that cholesterol enters the body via intestinal absorption or endogenous synthesis, and is excreted out of the body via a hepatobiliary route, either as free sterol ..
- Role and Relevance of Pept1 in Drug Absorption, Disposition, and DynamicsDavid E Smith; Fiscal Year: 2013..oligopeptide transporter (POT) of the SLC15 family, has nutritional importance because of its intestinal absorption of small peptides from the diet and because of its reabsorption of peptide-bound amino nitrogen from ..
- High throughput screens for fatty acid uptake inhibitorsConcetta C DiRusso; Fiscal Year: 2013..We also expect some of the compounds we identify may be employed to specifically reduce intestinal absorption as a primary step in preventing absorption of excess fat calories...
- Milk-based nano-delivery system for hydrophobic drugs in infants and childrenTomas Martin-Jimenez; Fiscal Year: 2012..The central hypothesis is that the casein micelle can be modified to facilitate the intestinal absorption of hydrophobic molecules...
- Chemoprevention of lung cancer with red ginseng extractsMing You; Fiscal Year: 2012..via in vitro activity- guided fractionation chromatographic separation supplemented by measuring their intestinal absorption potentials...
- Protection against radiation-induced damage to intestinal nutrient transportRoger Howell; Fiscal Year: 2009..For almost all nutrients, the rate-limiting step of intestinal absorption is transport across the apical membrane...
- Role of a Novel Absorption Mechanism in Metformin Disposition and PharmacologyDhiren R Thakker; Fiscal Year: 2013..S. Food and Drug Administration in 1994, yet the mechanisms involved in its intestinal absorption and its pharmacologic actions are not well understood to date...
- HFE: A Genetic Determinant of Olfactory Mn Absorption and ToxicityMarianne Wessling Resnick; Fiscal Year: 2010..The missense variants C282Y and H63D promote increased intestinal absorption and progressive tissue deposition of iron...
- Dietary Oxalate and Kidney Stone FormationDEAN GEORGE ASSIMOS; Fiscal Year: 2010..The second aim is to clarify the role of the oxalate-degrading organism, Oxalobacter formigenes in large intestinal absorption. The third aim seeks to translate these findings into directed therapies that prevent stone recurrence...
- Cellular models of microvillus inclusion diseaseH Lee Sweeney; Fiscal Year: 2013..This results in a lss of intestinal absorption, rapidly leading to death without parenteral nutrition (TPN)...
- Prenatal Alcohol Exposure Dysregulates Fetal Iron HomeostasisShane M Huebner; Fiscal Year: 2013..Under "normal" iron intakes alcohol enhances the intestinal absorption and liver deposition of iron, resulting in an iron overload status that exacerbates liver injury...
- A New Target for Kidney Stone Prevention: Calcium-Sensitive Transport of CitrateKathleen S Hering-Smith; Fiscal Year: 2013..3) Determine the role of NaDC1 in renal reabsorption &intestinal absorption of citrate...
- Drug-Dietary Flavonoid Intestinal Absorption InteractionROSITA PROTEAU; Fiscal Year: 2002..Thus, the results of this study will increase our understanding of the role of flavonoids found in tea, vegetables, soy, and dietary supplements in the intestinal absorption of therapeutic drugs.
- Roles of SLC26A6 in Renal NaCI Transport and Prevention of Oxalate UrolithiasisPeter S Aronson; Fiscal Year: 2013..They demonstrated that the latter process is critical to limiting net intestinal absorption of oxalate and preventing hyperoxaluria and calcium oxalate urolithiasis...
- EFFECTS OF BILE ACIDS ON CALCIUM AND IRON ABSORPTIONEdward Moore; Fiscal Year: 1990..high-affinity binding of both Ca++ and Fe++ (and possibly Fe+++), play an important role in enhancing the intestinal absorption of these ions...
- SPHINGOLIPIDS AND STEROLS--METABOLISM AND INTERACTIONSSeiichi Matsuda; Fiscal Year: 2000..and their actions on acyl coenzyme A-cholesterol acyltransferase, studies of relevance to the intestinal absorption of cholesterol and the pathogenesis of atherosclerosis...
- MOTILITY OF THE DIGESTIVE TRACT IN HEALTH AND DISEASEKEITH KELLY; Fiscal Year: 1993..neurotensin and enteroglucagon, slow the rate of gastric emptying and intestinal transit and enhance intestinal absorption of liquids and solids after ileal pouch-anal anastomosis...
- HEPATIC DRUG ELIMINATION IN PREGNANCYMary Vore; Fiscal Year: 2010..MRP2 is critical for elimination of polar metabolites from liver and kidney, as well decreasing the intestinal absorption of dietary carcinogensand its expression in liver is decreasedin pregnancy...
- HEPATIC DRUG ELIMINATION IN PREGNANCYMary Vore; Fiscal Year: 2007..MRP2 is critical for elimination of polar metabolites from liver and kidney, as well decreasing the intestinal absorption of dietary carcinogens and its expression in liver is decreased in pregnancy...
- Absorption and Metabolism of IsoflavonesMing Hu; Fiscal Year: 2005..form the basis for future efficacy studies to determine if improved bioavailability (through manipulating intestinal absorption and biotransformation) will translate into increased efficacy...
- STRUCTURE & FUNCTION OF B12 BINDING PROTEINSRobert Allen; Fiscal Year: 1993..We will further define the ileal and neutrophil-hepatocyte mechanisms that prevent the intestinal absorption and tissue dissemination of potentially toxic Cb1 analogues of bacterial origin and determine if these Cb1 ..
- BREAST CANCER RISK--VEGETABLES AND SERUM PHYTOSTEROLSPaola Muti; Fiscal Year: 2000..synthesized in human body: the phytosterols present in human blood derive solely from diet via intestinal absorption. B-sitosterol and campesterol are the predominant phytosterols in blood...
- DISTRIBUTION AND TRANSPORT OF LIPIDS IN MUCIN GELSTimothy Wiedmann; Fiscal Year: 2000..The hypothesis to be tested is that the association of lipids with mucin quantitatively affects the intestinal absorption of lipids and poorly water soluble drugs...
- NEONATAL NUTRITION: DEVELOPMENT OF FAT ABSORPTIONROGER LESTER; Fiscal Year: 1991..We have shown that such fundamental processes as bile acid synthesis, hepatic secretion, and intestinal absorption, are incompletely developed at birth and undergo maturation during the first weeks of life...
- Quantifying the impact of diet on carcinogen exposureJAMES FELTON; Fiscal Year: 2003..carcinogens from the digestates using the human colon carcinoma cell line Caco2, a commonly used model for intestinal absorption, 3) determine the effects of single and multiple food interactions on carcinogen bioavailability in a ..
- ION TRANSPORT IN SMALL INTESTINEWilliam Armstrong; Fiscal Year: 1991..modify or regulate these transport processes, and the role of specific membrane transport processes in intestinal absorption and secretion...
- Microvascular Regulation During Intestinal AbsorptionHAROLD G BOHLEN; Fiscal Year: 2010..A substantial fraction of the NO in blood may be from NO loading in the small arteries based on their very high wall NO concentration and represents a new form of vascular regulation. ..
- EVALUATION OF INTESTINAL ABSORPTION OF BETA-CAROTENESohrab Mobarhan; Fiscal Year: 1990..BC VA are with various amounts of food in young and old subjects have shown that several factors influence intestinal absorption of BC...
- NUTRITIONAL STUDIES ON BIOTON ABSORPTIONHAMID SAID; Fiscal Year: 1990..Aging is associated with a decrease in the plasma biotin level. Since changes in intestinal absorption of certain nutrients occur with aging, we will study biotin absorption process in aged animals to ..
- SitosterolemiaGerald Salen; Fiscal Year: 2003..sitostanol and campestanol) and cholestanol accumulate in all tissues except brain because of enhanced intestinal absorption and reduced hepatic removal...
- NOVEL METHOD FOR INTESTINAL ABSORPTION OF ANTIBODIESKeith Mostov; Fiscal Year: 1999....
- KHCO3 PREVENTS NACL INDUCED BONE RESORPTION IN HUMANS?Anthony Sebastian; Fiscal Year: 1999..of skeletal calcium leads to homeostatic adjustments of parathyroid and vitamin D activity that increase intestinal absorption of dietary calcium...
- Enhancing Thrombostatin's Oral DeliveryJohn Hilfinger; Fiscal Year: 2006..Specific Aim #2: Evaluation of Intestinal Absorption of the Thrombostatin Analogs: The new Thrombostatin analogs will be evaluated for intestinal stability and ..
- IN VITRO DELIVERABILITY OF ANTI-ANTHRAX DISCOVERY LEADSR Porter; Fiscal Year: 2000..3. Apply an in vitro (Caco-2 cells) intestinal absorption model to evaluate the deliverability of the biological active model inhibitors...
- Role of ABCG5 and ABCG8 in Sterol MetabolismHelen Hobbs; Fiscal Year: 2007..sterol transport in the body have been well defined: sterols enter the body via endogenous synthesis and intestinal absorption and are excreted via the liver into the bile, either as the free sterol or after conversion to bile acids...
- INHIBITION OF INTESTINAL HEME IRON ABSORPTIONJC BOMMER; Fiscal Year: 2000Iron overload conditions such as thalassemia and hemochromatosis result from the increased intestinal absorption of iron from inorganic iron and heme iron...
- SFT FUNCTION AND REGULATION IN HEMOCHROMATOSISMarianne Wessling Resnick; Fiscal Year: 2003Hereditary hemochromatosis is a genetic disorder that promotes increased intestinal absorption and progressive tissue deposition of iron resulting in cirrhosis of the liver, hepatic carcinoma, congestive heart failure, endocrinopathies ..
- INTESTINAL VITAMIN A BINDING PROTEINSEllen Li; Fiscal Year: 1992..An understanding of the mechanisms involved in intestinal absorption of vitamin A may prove valuable in the design of oral supplementation programs...
- The Role of Nitric Oxide in Cholesterol HomeostasisMelanie Ihrig; Fiscal Year: 2003DESCRIPTION (provided by applicant) Cholesterol homeostasis is maintained by balancing intestinal absorption, endogenous biosynthesis, hepatic uptake and biliary secretion of cholesterol and bile acids...
- RESVERATROL BIOAVAILABILITY--PRECLINICAL AND CLINICALThomas Walle; Fiscal Year: 2002..we are using an intermediary preclinical approach, using the Caco-2 cell line as model of human intestinal absorption as well as metabolism...
- UPTAKE AND ACTIONS OF GENISTEIN IN MAMMARY CANCER MODELSStephen Barnes; Fiscal Year: 1999..b>Intestinal absorption will be studied using everted intestinal sac preparations...
- Regulation of heme uptake in intestinal epithelial cellsAliye Uc; Fiscal Year: 2007..Heme provides the majority of body's iron, but little is known about its intestinal absorption. Dr...
- Luminal Lipid Exposure, Genetics and Colon Cancer RiskIkuko Kato; Fiscal Year: 2006..We hypothesize that individuals with genotypes for lower intestinal absorption, which results in more intracolonic exposure to potentially carcinogenic substances, have a higher risk of ..
- INTERACTIONS AFFECTING PHENYTOIN INTESTINALDavid Fleisher; Fiscal Year: 1991..of the proposed research is to determine the extent to which coadministered glucose and calcium affect the intestinal absorption of the orally administered anticonvulsant, phenytoin, from solution...
- SECOND GENERATION ANTIBIOTICS FROM ETHAMBUTOLMarina Protopopova; Fiscal Year: 2000..Medicinal chemistry will be guided by both SAR and likelihood of intestinal absorption. We propose a series of biochemical analyses that will allow us to prioritize hit molecules and confirm ..