oxidative phosphorylation

Summary

Summary: Electron transfer through the cytochrome system liberating free energy which is transformed into high-energy phosphate bonds.

Top Publications

  1. ncbi PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
    Vamsi K Mootha
    Whitehead Institute MIT Center for Genome Research, Cambridge, Massachusetts, USA
    Nat Genet 34:267-73. 2003
  2. ncbi Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells
    Min Wu
    Seahorse Bioscience, 16 Esquire Road, North Billerica, MA 01862, USA
    Am J Physiol Cell Physiol 292:C125-36. 2007
  3. ncbi Energy substrate modulates mitochondrial structure and oxidative capacity in cancer cells
    Rodrigue Rossignol
    Institute of Molecular Biology, University of Oregon, Eugene, Oregon, USA
    Cancer Res 64:985-93. 2004
  4. pmc The role of mitochondria in the pathogenesis of type 2 diabetes
    Mary Elizabeth Patti
    Research Division, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    Endocr Rev 31:364-95. 2010
  5. ncbi Mitochondrial dysfunction and type 2 diabetes
    Bradford B Lowell
    Department of Medicine, Beth Israel Deaconess Medical Center, 99 Brookline Avenue, Harvard Medical School, Boston, MA 02215, USA
    Science 307:384-7. 2005
  6. ncbi Mitochondrial diseases in man and mouse
    D C Wallace
    Center for Molecular Medicine, Emory University, 1462 Clifton Road, Suite 420, Atlanta, GA 30322, USA
    Science 283:1482-8. 1999
  7. pmc Corepressor SMRT promotes oxidative phosphorylation in adipose tissue and protects against diet-induced obesity and insulin resistance
    Sungsoon Fang
    Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA
    Proc Natl Acad Sci U S A 108:3412-7. 2011
  8. pmc Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1
    Mary Elizabeth Patti
    Research Division, Joslin Diabetes Center, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 100:8466-71. 2003
  9. pmc Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice
    Virginie Rhein
    Neurobiology Laboratory for Brain Aging and Mental Health, Psychiatric University Clinics, University of Basel, 4025 Basel, Switzerland
    Proc Natl Acad Sci U S A 106:20057-62. 2009
  10. ncbi Mitochondrial medicine--molecular pathology of defective oxidative phosphorylation
    E Fosslien
    Department of Pathology, College of Medicine, University of Illinois at Chicago, 60612, USA
    Ann Clin Lab Sci 31:25-67. 2001

Research Grants

  1. SIRT1 Overexpression in Cellular Mitochondrial Metabolism and Function
    James Russell; Fiscal Year: 2009
  2. OPTIC NEUROPATHY FROM MITOCHONDRIAL DERANGEMENT
    Alfredo Sadun; Fiscal Year: 1999
  3. STRUCTURE AND FUNCTION OF THE TRANSFERRIN RECEPTOR
    CAROLINE ENNS; Fiscal Year: 2002
  4. Modulation of Mitochondrial Function by Pro-Oxidants
    LUKE IGNATIUS SZWEDA; Fiscal Year: 2010
  5. ELECTRON-TRANSFER PROTEINS
    FRANCIS S contact MILLETT; Fiscal Year: 2010
  6. PROTON TRANSLOCATING SECTOR OF E COLI H+ ATPASE
    ROBERT FILLINGAME; Fiscal Year: 2003
  7. Molecular Adaptation of Hypoxia in Oxygen Sensing Cells
    David Millhorn; Fiscal Year: 2007
  8. DIAPHRAGM ADAPTATIONS TO CHRONIC RESISTIVE LOADING
    David Prezant; Fiscal Year: 2001
  9. OXIDATIVE PHOSPHORYLATION IN CARDIAC HYPERTROPHY
    TERRENCE O BRIEN; Fiscal Year: 2000
  10. Mitochondrial dysfunction in HAART: Point of care tests
    Michael F Marusich; Fiscal Year: 2010

Detail Information

Publications277 found, 100 shown here

  1. ncbi PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
    Vamsi K Mootha
    Whitehead Institute MIT Center for Genome Research, Cambridge, Massachusetts, USA
    Nat Genet 34:267-73. 2003
    ..Using this approach, we identify a set of genes involved in oxidative phosphorylation whose expression is coordinately decreased in human diabetic muscle...
  2. ncbi Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells
    Min Wu
    Seahorse Bioscience, 16 Esquire Road, North Billerica, MA 01862, USA
    Am J Physiol Cell Physiol 292:C125-36. 2007
    ..The converse, however, was not true. The cell lines were attenuated in oxidative phosphorylation (OXPHOS) capacity and were unable to sufficiently upregulate mitochondrial OXPHOS when glycolysis was ..
  3. ncbi Energy substrate modulates mitochondrial structure and oxidative capacity in cancer cells
    Rodrigue Rossignol
    Institute of Molecular Biology, University of Oregon, Eugene, Oregon, USA
    Cancer Res 64:985-93. 2004
    ..tumors relative to normal tissues generally reveals a strong diminution in mitochondrial content and in oxidative phosphorylation capacity...
  4. pmc The role of mitochondria in the pathogenesis of type 2 diabetes
    Mary Elizabeth Patti
    Research Division, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    Endocr Rev 31:364-95. 2010
    ....
  5. ncbi Mitochondrial dysfunction and type 2 diabetes
    Bradford B Lowell
    Department of Medicine, Beth Israel Deaconess Medical Center, 99 Brookline Avenue, Harvard Medical School, Boston, MA 02215, USA
    Science 307:384-7. 2005
    ..Emerging evidence supports the potentially unifying hypothesis that both of these prominent features of type 2 diabetes are caused by mitochondrial dysfunction...
  6. ncbi Mitochondrial diseases in man and mouse
    D C Wallace
    Center for Molecular Medicine, Emory University, 1462 Clifton Road, Suite 420, Atlanta, GA 30322, USA
    Science 283:1482-8. 1999
    ..The essential role of mitochondrial oxidative phosphorylation in cellular energy production, the generation of reactive oxygen species, and the initiation of ..
  7. pmc Corepressor SMRT promotes oxidative phosphorylation in adipose tissue and protects against diet-induced obesity and insulin resistance
    Sungsoon Fang
    Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA
    Proc Natl Acad Sci U S A 108:3412-7. 2011
    ....
  8. pmc Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1
    Mary Elizabeth Patti
    Research Division, Joslin Diabetes Center, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 100:8466-71. 2003
    ..Decreased PGC1 expression may be responsible for decreased expression of NRF-dependent genes, leading to the metabolic disturbances characteristic of insulin resistance and DM...
  9. pmc Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice
    Virginie Rhein
    Neurobiology Laboratory for Brain Aging and Mental Health, Psychiatric University Clinics, University of Basel, 4025 Basel, Switzerland
    Proc Natl Acad Sci U S A 106:20057-62. 2009
    ..24 proteins, of which one-third were mitochondrial proteins mainly related to complexes I and IV of the oxidative phosphorylation system (OXPHOS)...
  10. ncbi Mitochondrial medicine--molecular pathology of defective oxidative phosphorylation
    E Fosslien
    Department of Pathology, College of Medicine, University of Illinois at Chicago, 60612, USA
    Ann Clin Lab Sci 31:25-67. 2001
    Different tissues display distinct sensitivities to defective mitochondrial oxidative phosphorylation (OXPHOS)...
  11. ncbi Choosing between glycolysis and oxidative phosphorylation: a tumor's dilemma?
    Caroline Jose
    MRGM, Laboratoire Maladies Rares Génétique et Métabolisme, F 33076 Bordeaux, France
    Biochim Biophys Acta 1807:552-61. 2011
    ..cell lines is well described and recent analyses give a better view of the changes in mitochondrial oxidative phosphorylation during oncogenesis...
  12. pmc LRPPRC and SLIRP interact in a ribonucleoprotein complex that regulates posttranscriptional gene expression in mitochondria
    Florin Sasarman
    Department of Human Genetics, Montreal Neurological Institute, McGill University, Montreal, QC, H3A 2B4, Canada
    Mol Biol Cell 21:1315-23. 2010
    ..Further knockdown of LRPPRC produces a generalized assembly defect in all oxidative phosphorylation complexes containing mtDNA-encoded subunits, due to a severe decrease in all mitochondrial mRNAs...
  13. ncbi High-resolution respirometry: OXPHOS protocols for human cells and permeabilized fibers from small biopsies of human muscle
    Dominik Pesta
    D Swarovski Research Laboratory, Department of General and Transplant Surgery, Medical University of Innsbruck, Innrain 52, Christoph Probst Platz, 6020 Innsbruck, Austria
    Methods Mol Biol 810:25-58. 2012
    ..Multiple substrate-uncoupler-inhibitor titration (SUIT) protocols for analysis of oxidative phosphorylation improve our understanding of mitochondrial respiratory control and the pathophysiology of mitochondrial ..
  14. pmc Ketones and lactate increase cancer cell "stemness," driving recurrence, metastasis and poor clinical outcome in breast cancer: achieving personalized medicine via Metabolo-Genomics
    Ubaldo E Martinez-Outschoorn
    The Jefferson Stem Cell Biology and Regenerative Medicine Center, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 10:1271-86. 2011
    ..Importantly, this powerful new approach directly links cancer cell metabolism with clinical outcome, and new therapeutic strategies for inhibiting the TCA cycle and mitochondrial oxidative phosphorylation in cancer cells.
  15. pmc Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming
    Clifford D L Folmes
    Center for Regenerative Medicine and Marriott Heart Disease Research Program, Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Cell Metab 14:264-71. 2011
    ..Functional metamorphosis of somatic oxidative phosphorylation into acquired pluripotent glycolytic metabolism conformed to an embryonic-like archetype...
  16. ncbi Respiratory active mitochondrial supercomplexes
    Rebeca Acín-Pérez
    Departamento de Bioquimica, Universidad de Zaragoza, Miguel Servet, 177, 50013 Zaragoza, Spain
    Mol Cell 32:529-39. 2008
    ..Therefore, we have demonstrated the existence of a functional respirasome and propose a structural organization model that accommodates these findings...
  17. pmc The estrogen-related receptor alpha (ERRalpha) functions in PPARgamma coactivator 1alpha (PGC-1alpha)-induced mitochondrial biogenesis
    Sylvia N Schreiber
    Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    Proc Natl Acad Sci U S A 101:6472-7. 2004
    ..gamma (PPARgamma) coactivator 1alpha], and that it regulates the expression of genes involved in oxidative phosphorylation and mitochondrial biogenesis...
  18. pmc Mitochondrial translation and beyond: processes implicated in combined oxidative phosphorylation deficiencies
    Paulien Smits
    Department of Pediatrics, Nijmegen Center for Mitochondrial Disorders, Radboud University Nijmegen Medical Center, Geert Grooteplein 10, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    J Biomed Biotechnol 2010:737385. 2010
    ..These disorders are caused by defects in the oxidative phosphorylation (OXPHOS) system, which comprises five multisubunit enzyme complexes encoded by both the nuclear and the ..
  19. pmc A computational screen for regulators of oxidative phosphorylation implicates SLIRP in mitochondrial RNA homeostasis
    Joshua M Baughman
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA
    PLoS Genet 5:e1000590. 2009
    The human oxidative phosphorylation (OxPhos) system consists of approximately 90 proteins encoded by nuclear and mitochondrial genomes and serves as the primary cellular pathway for ATP biosynthesis...
  20. ncbi Impaired insulin secretion and beta-cell loss in tissue-specific knockout mice with mitochondrial diabetes
    J P Silva
    Department of Molecular Medicine, Karolinska Institutet, Karolinska Hospital, Stockholm, Sweden
    Nat Genet 26:336-40. 2000
    ..developed diabetes from the age of approximately 5 weeks and displayed severe mtDNA depletion, deficient oxidative phosphorylation and abnormal appearing mitochondria in islets at the ages of 7-9 weeks...
  21. ncbi Skeletal muscle "mitochondrial deficiency" does not mediate insulin resistance
    John O Holloszy
    Division of Geriatrics and Nutritional Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Clin Nutr 89:463S-6S. 2009
    ..Furthermore, it was recently shown that skeletal muscle mitochondrial capacity for oxidative phosphorylation in Asian Indians with type 2 diabetes is the same as in nondiabetic Indians and higher than in healthy ..
  22. ncbi Waves of gene regulation suppress and then restore oxidative phosphorylation in cancer cells
    Katarina Smolkova
    Department of Membrane Transport Biophysics, Institute of Physiology, vvi, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Int J Biochem Cell Biol 43:950-68. 2011
    ..wave" of adaptation stimulates glutaminolysis, which in certain cases partially re-establishes oxidative phosphorylation; this involves the LKB1-AMPK-p53, PI3K-Akt-mTOR axes and MYC dysregulation...
  23. ncbi Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance
    Valeria R Fantin
    Department of Genetics, Harvard Medical School and Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA
    Cancer Cell 9:425-34. 2006
    ..These results demonstrate that LDH-A plays a key role in tumor maintenance...
  24. ncbi Circumventing the Crabtree effect: replacing media glucose with galactose increases susceptibility of HepG2 cells to mitochondrial toxicants
    Lisa D Marroquin
    Pfizer DSRD, San Diego, CA 92121, USA
    Toxicol Sci 97:539-47. 2007
    ..effects in a preclinical cell-based assay, HepG2 cells were forced to rely on mitochondrial oxidative phosphorylation rather than glycolysis by substituting galactose for glucose in the growth media...
  25. ncbi Implications of mitochondrial DNA mutations and mitochondrial dysfunction in tumorigenesis
    Jianxin Lu
    Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Science, Wenzhou Medical College, Wenzhou, China
    Cell Res 19:802-15. 2009
    Alterations in oxidative phosphorylation resulting from mitochondrial dysfunction have long been hypothesized to be involved in tumorigenesis...
  26. pmc TEFM (c17orf42) is necessary for transcription of human mtDNA
    Michal Minczuk
    MRC Mitochondrial Biology Unit, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 0XY, UK
    Nucleic Acids Res 39:4284-99. 2011
    ..TEFM contains two HhH motifs and a Ribonuclease H fold, similar to the nuclear transcription elongation regulator Spt6. These findings lead us to propose that TEFM is a mitochondrial transcription elongation factor...
  27. pmc Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes
    Kitt Falk Petersen
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510, USA
    N Engl J Med 350:664-71. 2004
    ..Insulin resistance appears to be the best predictor of the development of diabetes in the children of patients with type 2 diabetes, but the mechanism responsible is unknown...
  28. ncbi Uncoupling to survive? The role of mitochondrial inefficiency in ageing
    M D Brand
    MRC Dunn Human Nutrition Unit, Hills Road, CB2 2XY, Cambridge, UK
    Exp Gerontol 35:811-20. 2000
    Mitochondria are incompletely coupled, and during oxidative phosphorylation some of the redox energy in substrates is lost as heat. Incomplete coupling is mostly due to a natural leak of protons across the mitochondrial inner membrane...
  29. ncbi Energetic requirements and bioenergetic modulation of mitochondrial morphology and dynamics
    Cécile Sauvanet
    Institut de biochimie et génétique cellulaires IBGC, CNRS UMR 5095, Bordeaux, France
    Semin Cell Dev Biol 21:558-65. 2010
    ..Finally, ex vivo studies (in mammals) and in vitro studies (in yeast) confirm the essential role of the inner membrane potential for mitochondrial fusion...
  30. ncbi Impaired oxidative phosphorylation in skeletal muscle of intrauterine growth-retarded rats
    Mary A Selak
    Department of Pediatrics, Children s Hospital of Philadelphia and University of Pennsylvania, 19104, USA
    Am J Physiol Endocrinol Metab 285:E130-7. 2003
    ..Such a defect in IUGR mitochondria leads to a chronic reduction in the supply of ATP available from oxidative phosphorylation. Impaired ATP synthesis in muscle compromises energy-dependent GLUT4 recruitment to the cell surface, ..
  31. ncbi Up-regulation of key microRNAs, and inverse down-regulation of their predicted oxidative phosphorylation target genes, during aging in mouse brain
    Na Li
    Gheens Center on Aging, University of Louisville School of Medicine, USA
    Neurobiol Aging 32:944-55. 2011
    ..We found unique de-regulated microRNAs shared between aging brain and aging liver, as well as brain- vs. liver-specific microRNAs during normal aging...
  32. ncbi Supramolecular organisation of the mitochondrial respiratory chain: a new challenge for the mechanism and control of oxidative phosphorylation
    Giorgio Lenaz
    Department of Biochemistry, University of Bologna, Bologna, Italy
    Adv Exp Med Biol 748:107-44. 2012
    ....
  33. pmc mTERF2 regulates oxidative phosphorylation by modulating mtDNA transcription
    Tina Wenz
    Department of Neurology, University of Miami School of Medicine, Miami, FL 33136, USA
    Cell Metab 9:499-511. 2009
    Regulation of mitochondrial protein expression is crucial for the function of the oxidative phosphorylation (OXPHOS) system...
  34. ncbi CRIF1 is essential for the synthesis and insertion of oxidative phosphorylation polypeptides in the mammalian mitochondrial membrane
    Soung Jung Kim
    Research Center for Endocrine and Metabolic Diseases, Chungnam National University School of Medicine, Daejeon 301 721, Korea
    Cell Metab 16:274-83. 2012
    ..factors involved in mitoribosome-mediated synthesis and simultaneous insertion of mitochondrial oxidative phosphorylation (OXPHOS) polypeptides into the inner membrane of mitochondria are still unclear...
  35. pmc K-ras(G12V) transformation leads to mitochondrial dysfunction and a metabolic switch from oxidative phosphorylation to glycolysis
    Yumin Hu
    State Key Laboratory of Oncology in Southern China, Sun Yat sen University Cancer Center, Guangzhou, Guangdong 510275, China
    Cell Res 22:399-412. 2012
    ..Our study suggests that induction of mitochondrial dysfunction is an important mechanism by which K-ras(G12V) causes metabolic changes and ROS stress in cancer cells, and promotes tumor development...
  36. ncbi Dual function of a new nuclear gene for oxidative phosphorylation and vegetative growth in yeast
    T Lisowsky
    Botanisches Institut, Heinrich Heine Universitat Dusseldorf, FRG
    Mol Gen Genet 232:58-64. 1992
    ..This conditional nuclear mutation selectively affects oxidative phosphorylation at restrictive temperatures...
  37. pmc Pink1 regulates the oxidative phosphorylation machinery via mitochondrial fission
    Wencheng Liu
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 108:12920-4. 2011
    ..Taken together, these results suggest a unique pathogenic mechanism of PINK1 PD: The loss of PINK1 impairs mitochondrial fission, which causes defective assembly of the ETC complexes, leading to abnormal bioenergetics...
  38. pmc Phenethyl isothiocyanate inhibits oxidative phosphorylation to trigger reactive oxygen species-mediated death of human prostate cancer cells
    Dong Xiao
    Department of Pharmacology and Chemical Biology and University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 285:26558-69. 2010
    ..cell death is initiated by production of reactive oxygen species (ROS) resulting from inhibition of oxidative phosphorylation (OXPHOS)...
  39. ncbi Mitochondrial H(+) leak and ROS generation: an odd couple
    Paul S Brookes
    Department of Anesthesiology, University of Rochester, Medical Center Box 604, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Free Radic Biol Med 38:12-23. 2005
    The single-electron chemistry of mitochondrial oxidative phosphorylation (ox-phos) by default generates reactive oxygen species (ROS). These ROS have roles in both physiologic cell signaling and numerous pathologic situations...
  40. pmc MicroRNA-338 regulates local cytochrome c oxidase IV mRNA levels and oxidative phosphorylation in the axons of sympathetic neurons
    Armaz Aschrafi
    Laboratory of Molecular Biology, National Institute of Mental Health National Institutes of Health, Bethesda, Maryland 20892 1381, USA
    J Neurosci 28:12581-90. 2008
    ..oligonucleotides that inhibit miR-338 increases COXIV levels, and results in a significant increase in oxidative phosphorylation and also norepinephrine uptake in the axons...
  41. ncbi Physiological diversity of mitochondrial oxidative phosphorylation
    G Benard
    INSERM U688, Physiopathologie Mitochondriale, Universite Victor Segalen Bordeaux 2, Bordeaux, France
    Am J Physiol Cell Physiol 291:C1172-82. 2006
    To investigate the physiological diversity in the regulation and control of mitochondrial oxidative phosphorylation, we determined the composition and functional features of the respiratory chain in muscle, heart, liver, kidney, and ..
  42. ncbi Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria
    Vamsi K Mootha
    MDS Proteomics, Odense 5230, Denmark
    Cell 115:629-40. 2003
    ....
  43. ncbi Computer modeling of mitochondrial tricarboxylic acid cycle, oxidative phosphorylation, metabolite transport, and electrophysiology
    Fan Wu
    Biotechnology and Bioengineering Center and Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Biol Chem 282:24525-37. 2007
    ....
  44. ncbi OPA1 mutations associated with dominant optic atrophy impair oxidative phosphorylation and mitochondrial fusion
    Claudia Zanna
    Dipartimento di Biologia Evoluzionistica Sperimentale, Universita di Bologna, Via Irnerio 42, 40126 Bologna, Italy
    Brain 131:352-67. 2008
    ..The results disclose a novel link between OPA1, apoptosis inducing factor and the respiratory complexes that may shed some light on the pathogenic mechanism of DOA...
  45. ncbi Effects of a high-fat diet on energy metabolism and ROS production in rat liver
    Guillaume Vial
    INSERM, U884, Grenoble, F 38041 France
    J Hepatol 54:348-56. 2011
    ..Steatosis is still poorly understood since diverse effects have been reported, depending on the different experimental models used...
  46. ncbi Expression of the Ciona intestinalis alternative oxidase (AOX) in Drosophila complements defects in mitochondrial oxidative phosphorylation
    Daniel J M Fernández-Ayala
    Institute of Medical Technology, Tampere University Hospital, University of Tampere, 33014 Tampere, Finland
    Cell Metab 9:449-60. 2009
    ..AOX appears to offer promise as a wide-spectrum therapeutic tool in OXPHOS disorders...
  47. ncbi Capacity of oxidative phosphorylation in human skeletal muscle: new perspectives of mitochondrial physiology
    Erich Gnaiger
    Department of General and Transplant Surgery, D Swarovski Research Laboratory, Medical University of Innsbruck, Innrain 66 6, A 6020 Innsbruck, Austria
    Int J Biochem Cell Biol 41:1837-45. 2009
    ..50-0.75 of capacity of oxidative phosphorylation (OXPHOS)...
  48. pmc Mitochondrial p32 protein is a critical regulator of tumor metabolism via maintenance of oxidative phosphorylation
    Valentina Fogal
    Cancer Research Center, Burnham Institute for Medical Research, 10901 N Torrey Pines Rd, La Jolla, California 92037, USA
    Mol Cell Biol 30:1303-18. 2010
    ..we show that knocking down p32 expression in human cancer cells strongly shifts their metabolism from oxidative phosphorylation (OXPHOS) to glycolysis...
  49. ncbi Warburg, me and Hexokinase 2: Multiple discoveries of key molecular events underlying one of cancers' most common phenotypes, the "Warburg Effect", i.e., elevated glycolysis in the presence of oxygen
    Peter L Pedersen
    Department of Biological Chemistry, Johns Hopkins University, School of Medicine, 725 North Wolfe Street, Baltimore, MD, 21205 2185, USA
    J Bioenerg Biomembr 39:211-22. 2007
    ..e., glycolysis and mitochondria) resulting in tumor destruction without harm to the animals...
  50. ncbi Identification of tyrosine-phosphorylated proteins of the mitochondrial oxidative phosphorylation machinery
    O Augereau
    Physiopathologie Mitochondriale, INSERM U688, Universite Victor Segalen Bordeaux 2, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
    Cell Mol Life Sci 62:1478-88. 2005
    ..The tyrosine phosphatase PTP 1B was found in brain but not in muscle, heart or liver mitochondria. Our results suggest that tyrosine kinases and phosphatases are involved in the regulation of oxidative phosphorylation.
  51. ncbi Coevolution predicts direct interactions between mtDNA-encoded and nDNA-encoded subunits of oxidative phosphorylation complex i
    Moran Gershoni
    Department of Life Sciences and the Nation Institute of Biotechnology in the Negev, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    J Mol Biol 404:158-71. 2010
    Despite years of research, the structure of the largest mammalian oxidative phosphorylation (OXPHOS) complex, NADH-ubiquinone oxidoreductase (complex I), and the interactions among its 45 subunits are not fully understood...
  52. pmc Mutations in the ND5 subunit of complex I of the mitochondrial DNA are a frequent cause of oxidative phosphorylation disease
    M J Blok
    Department of Clinical Genetics, University Hospital, Maastricht, The Netherlands
    J Med Genet 44:e74. 2007
    ..However, mutations in other mtDNA regions can be an important cause of oxidative phosphorylation (OXPHOS) disease as well.
  53. ncbi Components of mitochondrial oxidative phosphorylation vary in abundance following exposure to cold and chemical stresses
    Yew Foon Tan
    ARC Centre of Excellence in Plant Energy Biology, MCS building M316, The University of Western Australia, 35 Stirling Highway, Crawley WA 6009, Western Australia, Australia
    J Proteome Res 11:3860-79. 2012
    ..of plant mitochondria, arguably the site responsible for the most fundamental mitochondrial processes of oxidative phosphorylation, protein import and metabolite transport, remain a technical challenge...
  54. pmc Mutations in the mitochondrial methionyl-tRNA synthetase cause a neurodegenerative phenotype in flies and a recessive ataxia (ARSAL) in humans
    Vafa Bayat
    Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS Biol 10:e1001288. 2012
    ..We further observed that these mutants display defects in oxidative phosphorylation, increased Reactive Oxygen Species (ROS), and an upregulated mitochondrial Unfolded Protein Response...
  55. pmc Evolution meets disease: penetrance and functional epistasis of mitochondrial tRNA mutations
    Raquel Moreno-Loshuertos
    Departamento de Bioquimica y Biologia Molecular y Celular, Universidad de Zaragoza, Zaragoza, Spain
    PLoS Genet 7:e1001379. 2011
    ..This particular behavior can allow a scenario for the evolution of mitochondrial tRNAs in which the fixation of two alleles that are individually deleterious can proceed in two steps and not require the simultaneous mutation of both...
  56. ncbi Increase in mitochondrial DNA mutations impairs retinal function and renders the retina vulnerable to injury
    Yu X G Kong
    Centre for Eye Research Australia, University of Melbourne, Parkville, 3010 Victoria, Australia
    Aging Cell 10:572-83. 2011
    ..mice have increased mtDNA deletions and point mutations and decreased expression of mitochondrial oxidative phosphorylation enzymes...
  57. pmc Mitochondrial respiration protects against oxygen-associated DNA damage
    Ho Joong Sung
    Translational Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Nat Commun 1:5. 2010
    Oxygen is not only required for oxidative phosphorylation but also serves as the essential substrate for the formation of reactive oxygen species (ROS), which is implicated in ageing and tumorigenesis...
  58. pmc Increased mitochondrial oxidative phosphorylation in the liver is associated with obesity and insulin resistance
    David A Buchner
    Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Obesity (Silver Spring) 19:917-24. 2011
    ..between 6C1 and 6C2 in pathways related to basal transcription factors, endocytosis, and mitochondrial oxidative phosphorylation (OxPhos)...
  59. ncbi Mitochondrial dysfunction in glaucoma and emerging bioenergetic therapies
    Shanjean Lee
    Centre for Eye Research Australia, University of Melbourne, Department of Ophthalmology, Royal Victorian Eye and Ear Hospital, 32 Gisborne Street East, Melbourne, Victoria 3002, Australia
    Exp Eye Res 93:204-12. 2011
    ....
  60. pmc Subcomplex Ilambda specifically controls integrated mitochondrial functions in Caenorhabditis elegans
    Marni J Falk
    Division of Human Genetics, Department of Pediatrics, The Children s Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA, USA
    PLoS ONE 4:e6607. 2009
    ..We demonstrate that functional consequences of complex I deficiency vary with the particular subunit that is defective...
  61. ncbi UVB radiation induces persistent activation of ribosome and oxidative phosphorylation pathways
    Min Lung Tsai
    Department of Biomedical Engineering, National Tsing Hua University, Hsinchu, Taiwan
    Radiat Res 171:716-24. 2009
    ..we determined that genes participating in two prime cellular processes, the ribosome pathway and the oxidative phosphorylation pathway, were persistently activated after UVB irradiation...
  62. pmc Tissue-specific remodeling of the mitochondrial proteome in type 1 diabetic akita mice
    Heiko Bugger
    Division of Endocrinology, Metabolism and Diabetes, and Program in Molecular Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Diabetes 58:1986-97. 2009
    ..To elucidate the molecular basis for mitochondrial dysfunction, which has been implicated in the pathogenesis of diabetes complications...
  63. pmc The role of Ca(2+) signaling in the coordination of mitochondrial ATP production with cardiac work
    Robert S Balaban
    Laboratory of Cardiac Energetics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1787:1334-41. 2009
    ..How cytosolic Ca(2+) signaling might regulate oxidative phosphorylation is a focus of this review...
  64. ncbi A disproportionate role for mtDNA in Dobzhansky-Muller incompatibilities?
    Ronald S Burton
    Marine Biology Research Division, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093 0202, USA
    Mol Ecol 21:4942-57. 2012
    ..All mtDNA-encoded proteins are components of the oxidative phosphorylation (OXPHOS) system and all mtDNA-encoded RNAs are part of the mitochondrial protein synthetic machinery; ..
  65. ncbi Seizure-dependent modulation of mitochondrial oxidative phosphorylation in rat hippocampus
    Alexei P Kudin
    Department of Epileptology, University of Bonn Medical Centre, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Eur J Neurosci 15:1105-14. 2002
    ..Here, we demonstrate seizure-dependent changes in mitochondrial oxidative phosphorylation in the epileptic rat hippocampus...
  66. ncbi Mitochondrial expression and function of GAS-1 in Caenorhabditis elegans
    E B Kayser
    Department of Anesthesiology, University Hospitals, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 276:20551-8. 2001
    ..gene profoundly decreases Complex I-dependent metabolism in mitochondria as measured by rates of both oxidative phosphorylation and electron transport...
  67. ncbi Review: Mitochondrial medicine--cardiomyopathy caused by defective oxidative phosphorylation
    Egil Fosslien
    Department of Pathology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Ann Clin Lab Sci 33:371-95. 2003
    ..the majority of its requirement for adenosine triphosphate (ATP) from metabolism of fatty acids and oxidative phosphorylation (OXPHOS), to the fetal form, which metabolizes glucose and lactate...
  68. pmc High membrane potential promotes alkenal-induced mitochondrial uncoupling and influences adenine nucleotide translocase conformation
    Vian Azzu
    MRC Dunn Human Nutrition Unit, Wellcome Trust MRC Building, Hills Road, Cambridge, CB2 0XY, UK
    Biochem J 413:323-32. 2008
    ..species, whose downstream lipid peroxidation products, such as 4-hydroxynonenal, induce uncoupling of oxidative phosphorylation by increasing proton leak through mitochondrial inner membrane proteins such as the uncoupling proteins ..
  69. ncbi A pivotal role for p53: balancing aerobic respiration and glycolysis
    Wenzhe Ma
    Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Bioenerg Biomembr 39:243-6. 2007
    ..The biological significance of this regulation of the two major pathways of energy generation by p53 remains to be seen...
  70. ncbi Mitochondrial disorders
    Massimo Zeviani
    Division of Molecular Neurogenetics, Istituto Nazionale Neurologico C Besta, Via Celoria 11 20133 Milan, Italy
    Brain 127:2153-72. 2004
    ..e. oxidative phosphorylation (OXPHOS)...
  71. ncbi Defective oxidative phosphorylation in thyroid oncocytic carcinoma is associated with pathogenic mitochondrial DNA mutations affecting complexes I and III
    Elena Bonora
    Unità di Genetica Medica, Policlinico Universitario S Orsola Malpighi, Italy
    Cancer Res 66:6087-96. 2006
    ..UC1 is due to a combined complex I/III defect associated with mtDNA mutations, as proven by the transfer of the defective energetic phenotype with the mitochondrial genome into the cybrids...
  72. pmc Secondary mitochondrial dysfunction in propionic aciduria: a pathogenic role for endogenous mitochondrial toxins
    Marina A Schwab
    Department of General Pediatrics, Division of Inborn Metabolic Diseases, University Children s Hospital Heidelberg, Im Neuenheimer Feld 150, D 69120 Heidelberg, Germany
    Biochem J 398:107-12. 2006
    ..In line with the in vitro results, oxidative phosphorylation was severely compromised in both patients...
  73. ncbi Resveratrol protects against cold ischemia-warm reoxygenation-induced damages to mitochondria and cells in rat liver
    Catherine Plin
    INSERM, U660, Creteil, F 94010 France
    Eur J Pharmacol 528:162-8. 2005
    ..cellular damages as attested by the increase in lipid peroxidation of liver membranes, the alteration of oxidative phosphorylation parameters, mitochondrial swelling and the activation of the cellular markers of necrosis and apoptosis, ..
  74. pmc A Candida albicans petite mutant strain with uncoupled oxidative phosphorylation overexpresses MDR1 and has diminished susceptibility to fluconazole and voriconazole
    Shaoji Cheng
    University of Florida College of Medicine, JHMHC, Gainesville, FL 32610, USA
    Antimicrob Agents Chemother 51:1855-8. 2007
    We showed that a Candida albicans petite mutant in which oxidative phosphorylation is uncoupled was eightfold more resistant to fluconazole and voriconazole than SC5314 but equally susceptible to ketoconazole, itraconazole, and ..
  75. ncbi Hereditary optic neuropathies share a common mitochondrial coupling defect
    Arnaud Chevrollier
    Institut National de la Sante et de la Recherche Medicale, U694, Départment de Biochimie et Génétique, Centre Hospitalier Universitaire, Angers, France
    Ann Neurol 63:794-8. 2008
    ..We found a common coupling defect of oxidative phosphorylation in fibroblasts of patients affected by autosomal dominant optic atrophy (mutations of OPA1), autosomal ..
  76. pmc Cardiac mitochondria in heart failure: decrease in respirasomes and oxidative phosphorylation
    Mariana G Rosca
    Department of Medicine, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland 44106 4981, OH, USA
    Cardiovasc Res 80:30-9. 2008
    ..The aim of this study was to define the defect in the integrative function of cardiac mitochondria in coronary microembolization-induced HF...
  77. ncbi Energy thresholds in brain mitochondria. Potential involvement in neurodegeneration
    G P Davey
    Department of Neurochemistry, Institute of Neurology, Queen Square, London WC1N 3BG, United Kingdom
    J Biol Chem 273:12753-7. 1998
    ..However, the extent to which these decreases cause a disturbance in oxidative phosphorylation and energy homeostasis in the brain is not known...
  78. pmc Biochemical diagnosis of mitochondrial disorders
    Richard J T Rodenburg
    Nijmegen Center for Mitochondrial Disorders NCMD, 656 Department of Pediatrics, Department of Laboratory Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Inherit Metab Dis 34:283-92. 2011
    ..In addition to activity measurements of individual oxidative phosphorylation enzymes, analysis of mitochondrial respiration, substrate oxidation, and ATP production rates is ..
  79. pmc Thioredoxin-interacting protein (Txnip) gene expression: sensing oxidative phosphorylation status and glycolytic rate
    Fa Xing Yu
    Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, Singapore
    J Biol Chem 285:25822-30. 2010
    ..Txnip expression is down-regulated at the transcriptional level by diverse inhibitors of mitochondrial oxidative phosphorylation (OXPHOS)...
  80. ncbi Alterations in bioenergetics due to changes in mitochondrial DNA copy number
    Wei Qian
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, United States
    Methods 51:452-7. 2010
    ..of mtDNA due to dysfunctional mitochondrial DNA polymerase gamma (POLG) induce loss of mitochondrial oxidative phosphorylation (OXPHOS) and mitochondrial ATP generation...
  81. pmc AIF deficiency compromises oxidative phosphorylation
    Nicola Vahsen
    CNRS UMR8125, Institut Gustave Roussy, Villejuif, France
    EMBO J 23:4679-89. 2004
    ..mice with reduced AIF expression due to a retroviral insertion into the AIF gene also manifest a reduced oxidative phosphorylation (OXPHOS) in the retina and in the brain, correlating with reduced expression of complex I subunits, ..
  82. ncbi Transcriptional profiling of myotubes from patients with type 2 diabetes: no evidence for a primary defect in oxidative phosphorylation genes
    C M Frederiksen
    Department of Endocrinology, Odense University Hospital, Kløvervaenget 6, 5000, Odense C, Denmark
    Diabetologia 51:2068-77. 2008
    ..It is unknown whether reduced mitochondrial biogenesis or other transcriptional alterations co-exist with impaired insulin responsiveness in primary human muscle cells from patients with type 2 diabetes...
  83. pmc The oncogene c-Myc coordinates regulation of metabolic networks to enable rapid cell cycle entry
    Fionnuala Morrish
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Cell Cycle 7:1054-66. 2008
    ..with an inducible c-myc transgene (mycER), we show that the Myc protein programs cells to utilize both oxidative phosphorylation and glycolysis to drive cell cycle progression...
  84. ncbi Measurement of the energy-generating capacity of human muscle mitochondria: diagnostic procedure and application to human pathology
    Antoon J M Janssen
    Department of Pediatrics and Laboratory of Pediatrics and Neurology, the Nijmegen Centre for Mitochondrial Disorders NCMD, Nijmegen, The Netherlands
    Clin Chem 52:860-71. 2006
    ..Diagnosis of mitochondrial disorders usually requires a muscle biopsy to examine mitochondrial function. We describe our diagnostic procedure and results for 29 patients with mitochondrial disorders...
  85. ncbi Age influences DNA methylation and gene expression of COX7A1 in human skeletal muscle
    T Rönn
    Department of Clinical Sciences, CRC Malmö University Hospital, Lund University, 205 02, Malmo, Sweden
    Diabetologia 51:1159-68. 2008
    ..Moreover, a set of genes influencing oxidative phosphorylation (OXPHOS) is downregulated in diabetic muscle...
  86. ncbi Threshold effect and tissue specificity. Implication for mitochondrial cytopathies
    R Rossignol
    INSERM EMI 9929, , , F 33076 Bordeaux cedex, France
    J Biol Chem 274:33426-32. 1999
    ..It is based on the metabolic expression of the defect in oxidative phosphorylation (OXPHOS) complexes that can present a biochemical threshold...
  87. pmc Experimental assessment of bioenergetic differences caused by the common European mitochondrial DNA haplogroups H and T
    Taku Amo
    MRC Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 0XY, UK
    Gene 411:69-76. 2008
    ..We found that there were no functionally-important bioenergetic differences between mitochondria bearing these haplogroups, using either isolated mitochondria or mitochondria within cells...
  88. pmc Loss of p53 causes mitochondrial DNA depletion and altered mitochondrial reactive oxygen species homeostasis
    Maria A Lebedeva
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06520 8023, USA
    Biochim Biophys Acta 1787:328-34. 2009
    ..Altogether, these results elucidate additional mitochondria-related functions for p53 and implicate mtDNA depletion and ROS alterations as potentially relevant to cellular transformation, cancer cell phenotypes, and the Warburg Effect...
  89. pmc Silencing of PINK1 expression affects mitochondrial DNA and oxidative phosphorylation in dopaminergic cells
    Matthew E Gegg
    Department of Clinical Neurosciences, Institute of Neurology, University College London, Queen Square, London, United Kingdom
    PLoS ONE 4:e4756. 2009
    ..The PINK1 protein is a serine/threonine kinase localized in mitochondria and the cytosol. Its precise function is unknown, but it is involved in neuroprotection against a variety of stress signalling pathways...
  90. pmc Extension of chronological life span by reduced TOR signaling requires down-regulation of Sch9p and involves increased mitochondrial OXPHOS complex density
    Yong Pan
    Department of Pathology, Yale University School of Medicine, New Haven CT 06520, USA
    Aging (Albany NY) 1:131-45. 2009
    ..by increasing mitochondrial oxygen consumption, in part, by up-regulating translation of mtDNA-encoded oxidative phosphorylation (OXPHOS) subunits...
  91. pmc NOA1 is an essential GTPase required for mitochondrial protein synthesis
    Mateusz Kolanczyk
    Development and Disease Group, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany
    Mol Biol Cell 22:1-11. 2011
    ..from NOA1 knockout embryos show deficient mitochondrial protein synthesis and a global defect of oxidative phosphorylation (OXPHOS). Additionally, Noa1⁻/⁻ cells are impaired in staurosporine-induced apoptosis...
  92. ncbi Mitochondrial bioenergetic background confers a survival advantage to HepG2 cells in response to chemotherapy
    Dominique Loiseau
    INSERM U694, University Hospital Center, Angers, France
    Mol Carcinog 48:733-41. 2009
    ..should depend on cellular capability to produce sufficient ATP by upregulating glycolysis or recruiting oxidative phosphorylation (OXPHOS)...
  93. ncbi MTERF4 regulates translation by targeting the methyltransferase NSUN4 to the mammalian mitochondrial ribosome
    Yolanda Camara
    Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden
    Cell Metab 13:527-39. 2011
    Precise control of mitochondrial DNA gene expression is critical for regulation of oxidative phosphorylation capacity in mammals...
  94. pmc Phylogenomics of the oxidative phosphorylation in fungi reveals extensive gene duplication followed by functional divergence
    Marina Marcet-Houben
    Comparative Genomics, Centre for Genomics Regulation, 08003 Barcelona, Spain
    BMC Evol Biol 9:295. 2009
    b>Oxidative phosphorylation is central to the energy metabolism of the cell. Due to adaptation to different life-styles and environments, fungal species have shaped their respiratory pathways in the course of evolution...
  95. ncbi P/O ratios of mitochondrial oxidative phosphorylation
    Peter C Hinkle
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Biochim Biophys Acta 1706:1-11. 2005
    ..Stock, A.G.W. Leslie, J.E. Walker, Science 286 (1999) 1700-1705) which suggests that the H+/ATP ratio is 10/3, rather than 3, consistent with P/O ratios of 2.3 with NADH and 1.4 with succinate, values that are also possible...
  96. ncbi Respiration in adipocytes is inhibited by reactive oxygen species
    Tong Wang
    Obesity Research Center, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
    Obesity (Silver Spring) 18:1493-502. 2010
    ..Maximum O(2) consumption, in vitro, was determined with a chemical uncoupler of oxidative phosphorylation (carbonylcyanide p-trifluoromethoxyphenylhydrazone (FCCP))...
  97. pmc The striatum is highly susceptible to mitochondrial oxidative phosphorylation dysfunctions
    Alicia M Pickrell
    Neuroscience Graduate Program, University of Miami Miller School of Medicine, Miami, Florida 33133, USA
    J Neurosci 31:9895-904. 2011
    Neuronal oxidative phosphorylation (OXPHOS) deficiency has been associated with a variety of neurodegenerative diseases, including Parkinson's disease and Huntington's disease...
  98. pmc Control of oxidative phosphorylation by vitamin A illuminates a fundamental role in mitochondrial energy homoeostasis
    Rebeca Acín-Pérez
    Department of Neurology and Neurobiology Weill Cornell Medical School, New York, New York, USA
    FASEB J 24:627-36. 2010
    ..The data provide a mechanistic explanation to the nearly 100-yr-old question of why vitamin A deficiency causes so many pathologies that are independent of retinoic acid action...
  99. ncbi Transcriptional profiles in CD8+ T cells from HIV+ progressors on HAART are characterized by coordinated up-regulation of oxidative phosphorylation enzymes and interferon responses
    Jing Qin Wu
    Retroviral Genetics Division, Center for Virus Research, Westmead Millennium Institute, University of Sydney, Westmead, NSW, Australia
    Virology 380:124-35. 2008
    ..By GSEA, the coordinated up-regulation of oxidative phosphorylation enzymes and interferon responses were detected as fingerprints in HIV progressors on HAART, whereas LTNP ..
  100. ncbi Association of 3-methylglutaconic aciduria with sensori-neural deafness, encephalopathy, and Leigh-like syndrome (MEGDEL association) in four patients with a disorder of the oxidative phosphorylation
    S Wortmann
    Radboud University Nijmegen Medical Centre, Nijmegen Centre for Mitochondrial Disorders, Department of Pediatrics, The Netherlands
    Mol Genet Metab 88:47-52. 2006
    ..3-methylglutaconyl-CoA hydratase activity, cardiolipin levels, OPA3 gene analysis and measurement of the oxidative phosphorylation in four female patients with 3-methylglutaconic aciduria...
  101. pmc Genetic variation in ATP5O is associated with skeletal muscle ATP50 mRNA expression and glucose uptake in young twins
    Tina Rönn
    Department of Clinical Sciences, Diabetes and Endocrinology Research Unit, CRC Malmö University Hospital, Lund University, Malmo, Sweden
    PLoS ONE 4:e4793. 2009
    ..Furthermore, mRNA expression of genes involved in oxidative phosphorylation, including ATP5O, is reduced in skeletal muscle from T2D patients...

Research Grants12

  1. SIRT1 Overexpression in Cellular Mitochondrial Metabolism and Function
    James Russell; Fiscal Year: 2009
    ..Several lines of evidence indicate that a common link in these diseases is diminished mitochondrial oxidative phosphorylation and response to oxidative injury...
  2. OPTIC NEUROPATHY FROM MITOCHONDRIAL DERANGEMENT
    Alfredo Sadun; Fiscal Year: 1999
    ..In each case, there is evidence that singular or combined insults to mitochondrial oxidative phosphorylation impair ATP production, however, this does not explain why other metabolically active tissues such as ..
  3. STRUCTURE AND FUNCTION OF THE TRANSFERRIN RECEPTOR
    CAROLINE ENNS; Fiscal Year: 2002
    ..for the enzymatic activity of key proteins in the DNA synthetic pathway, electron transport in the oxidative phosphorylation pathway in mitochondria, the activity of enzymes in the citric acid cycle, and the activity of proteins ..
  4. Modulation of Mitochondrial Function by Pro-Oxidants
    LUKE IGNATIUS SZWEDA; Fiscal Year: 2010
    ..of cardiac energy status and function, mitochondria exhibit declines in the rate of respiration and oxidative phosphorylation during ischemia, with further age-dependent deficits evident upon reperfusion...
  5. ELECTRON-TRANSFER PROTEINS
    FRANCIS S contact MILLETT; Fiscal Year: 2010
    ..reactions play essential roles in numerous biological processes important to human health, including oxidative phosphorylation in mitochondria...
  6. PROTON TRANSLOCATING SECTOR OF E COLI H+ ATPASE
    ROBERT FILLINGAME; Fiscal Year: 2003
    A reversible, H+-transporting ATPase catalyzes ATP synthesis during oxidative phosphorylation. The enzyme is made up of two sectors. F1 lies at the membrane surface, and on isolation catalyzes ATP hydrolysis...
  7. Molecular Adaptation of Hypoxia in Oxygen Sensing Cells
    David Millhorn; Fiscal Year: 2007
    Mammalian cells require a constant supply of oxygen to maintain energy balance. Hypoxia leads to reduced oxidative phosphorylation and depletion of cellular ATP, which can result in cell death...
  8. DIAPHRAGM ADAPTATIONS TO CHRONIC RESISTIVE LOADING
    David Prezant; Fiscal Year: 2001
    ..ATP turnover, determined largely by myosin heavy chain (MHC) isoform composition, and b) mitochondrial oxidative phosphorylation capacity. This grant focuses on how these 2 factors are altered as the diaphragm adapts to CRRL...
  9. OXIDATIVE PHOSPHORYLATION IN CARDIAC HYPERTROPHY
    TERRENCE O BRIEN; Fiscal Year: 2000
    ..is an up regulation of several components of the nuclear and mitochondrially derived mitochondrial oxidative phosphorylation system at both the mRNA and protein level...
  10. Mitochondrial dysfunction in HAART: Point of care tests
    Michael F Marusich; Fiscal Year: 2010
    ..Mitochondrial Oxidative Phosphorylation (OXPHOS) protein levels are good candidates for early biomarkers of HAART toxicity as OXPHOS normally ..
  11. Mouse Modeling of Leigh Disease and Complex I Assembly
    Carl Pinkert; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Mitochondria provide energy for cells via oxidative phosphorylation (OXPHOS)...
  12. Proton-Translocating Sector of E. coli H+ATP Synthase
    Robert H Fillingame; Fiscal Year: 2010
    The H+-transporting F1Fo ATP synthases of oxidative phosphorylation in mitochondria and bacteria are very similar...