postmenopause

Summary

Summary: The physiological period following the MENOPAUSE, the permanent cessation of the menstrual life.

Top Publications

  1. ncbi Effect of exercise on total and intra-abdominal body fat in postmenopausal women: a randomized controlled trial
    Melinda L Irwin
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Conn, USA
    JAMA 289:323-30. 2003
  2. ncbi Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial
    Jacques E Rossouw
    Division of Women s Health Initiative, National Heart, Lung, and Blood Institute, 6705 Rockledge Dr, One Rockledge Ctr, Suite 300, Bethesda, MD 20817
    JAMA 288:321-33. 2002
  3. ncbi American Society of Clinical Oncology clinical practice guideline: update on adjuvant endocrine therapy for women with hormone receptor-positive breast cancer
    Harold J Burstein
    Dana Farber Cancer Institute, Boston, MA, USA
    J Clin Oncol 28:3784-96. 2010
  4. ncbi Body mass index, serum sex hormones, and breast cancer risk in postmenopausal women
    T J Key
    Cancer Research U K Epidemiology Unit, University of Oxford, Gibson Bldg, Radcliffe Infirmary, Oxford OX2 6HE, UK
    J Natl Cancer Inst 95:1218-26. 2003
  5. pmc Insulin, insulin-like growth factor-I, and risk of breast cancer in postmenopausal women
    Marc J Gunter
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, New York, NY 10461, USA
    J Natl Cancer Inst 101:48-60. 2009
  6. ncbi Pooled analysis of prospective cohort studies on height, weight, and breast cancer risk
    P A van den Brandt
    Department of Epidemiology, Maastricht University, The Netherlands
    Am J Epidemiol 152:514-27. 2000
  7. ncbi Mature results of a randomized phase II multicenter study of exemestane versus tamoxifen as first-line hormone therapy for postmenopausal women with metastatic breast cancer
    R Paridaens
    Universitair Ziekenhuis, Gasthuisberg, Leuven, Belgium
    Ann Oncol 14:1391-8. 2003
  8. pmc Validity of diabetes self-reports in the Women's Health Initiative: comparison with medication inventories and fasting glucose measurements
    Karen L Margolis
    HealthPartners Research Foundation, Minneapolis, MN 55440 1524, USA
    Clin Trials 5:240-7. 2008
  9. ncbi Exemestane for breast-cancer prevention in postmenopausal women
    Paul E Goss
    Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA
    N Engl J Med 364:2381-91. 2011
  10. pmc Randomized phase II neoadjuvant comparison between letrozole, anastrozole, and exemestane for postmenopausal women with estrogen receptor-rich stage 2 to 3 breast cancer: clinical and biomarker outcomes and predictive value of the baseline PAM50-based int
    Matthew J Ellis
    Siteman Cancer Center, Washington University in St Louis, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Clin Oncol 29:2342-9. 2011

Detail Information

Publications291 found, 100 shown here

  1. ncbi Effect of exercise on total and intra-abdominal body fat in postmenopausal women: a randomized controlled trial
    Melinda L Irwin
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Conn, USA
    JAMA 289:323-30. 2003
    ..The increasing prevalence of obesity is a major public health concern. Physical activity may promote weight and body fat loss...
  2. ncbi Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial
    Jacques E Rossouw
    Division of Women s Health Initiative, National Heart, Lung, and Blood Institute, 6705 Rockledge Dr, One Rockledge Ctr, Suite 300, Bethesda, MD 20817
    JAMA 288:321-33. 2002
    ..Despite decades of accumulated observational evidence, the balance of risks and benefits for hormone use in healthy postmenopausal women remains uncertain...
  3. ncbi American Society of Clinical Oncology clinical practice guideline: update on adjuvant endocrine therapy for women with hormone receptor-positive breast cancer
    Harold J Burstein
    Dana Farber Cancer Institute, Boston, MA, USA
    J Clin Oncol 28:3784-96. 2010
    ..To develop evidence-based guidelines, based on a systematic review, for endocrine therapy for postmenopausal women with hormone receptor-positive breast cancer...
  4. ncbi Body mass index, serum sex hormones, and breast cancer risk in postmenopausal women
    T J Key
    Cancer Research U K Epidemiology Unit, University of Oxford, Gibson Bldg, Radcliffe Infirmary, Oxford OX2 6HE, UK
    J Natl Cancer Inst 95:1218-26. 2003
    ..Obesity is associated with increased breast cancer risk among postmenopausal women. We examined whether this association could be explained by the relationship of body mass index (BMI) with serum sex hormone concentrations...
  5. pmc Insulin, insulin-like growth factor-I, and risk of breast cancer in postmenopausal women
    Marc J Gunter
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, New York, NY 10461, USA
    J Natl Cancer Inst 101:48-60. 2009
    ..However, no prospective studies have directly assessed associations between circulating levels of insulin and/or insulin-like growth factor (IGF)-I, a related hormone, and the risk of breast cancer independent of estrogen level...
  6. ncbi Pooled analysis of prospective cohort studies on height, weight, and breast cancer risk
    P A van den Brandt
    Department of Epidemiology, Maastricht University, The Netherlands
    Am J Epidemiol 152:514-27. 2000
    ..The association between BMI and breast cancer varies by menopausal status. Weight control may reduce the risk among postmenopausal women...
  7. ncbi Mature results of a randomized phase II multicenter study of exemestane versus tamoxifen as first-line hormone therapy for postmenopausal women with metastatic breast cancer
    R Paridaens
    Universitair Ziekenhuis, Gasthuisberg, Leuven, Belgium
    Ann Oncol 14:1391-8. 2003
    ..We explored the efficacy and safety of the steroidal aromatase inactivator exemestane as first-line hormonal therapy in MBC in postmenopausal women...
  8. pmc Validity of diabetes self-reports in the Women's Health Initiative: comparison with medication inventories and fasting glucose measurements
    Karen L Margolis
    HealthPartners Research Foundation, Minneapolis, MN 55440 1524, USA
    Clin Trials 5:240-7. 2008
    ..Therefore, we studied whether self-report of prevalent and incident diabetes in Women's Health Initiative (WHI) participants was concordant with other diagnostic evidence of diabetes...
  9. ncbi Exemestane for breast-cancer prevention in postmenopausal women
    Paul E Goss
    Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA
    N Engl J Med 364:2381-91. 2011
    ..Aromatase inhibitors prevent more contralateral breast cancers and cause fewer side effects than tamoxifen in patients with early-stage breast cancer...
  10. pmc Randomized phase II neoadjuvant comparison between letrozole, anastrozole, and exemestane for postmenopausal women with estrogen receptor-rich stage 2 to 3 breast cancer: clinical and biomarker outcomes and predictive value of the baseline PAM50-based int
    Matthew J Ellis
    Siteman Cancer Center, Washington University in St Louis, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Clin Oncol 29:2342-9. 2011
    ..To study this treatment option, responses to three AIs were compared in a randomized phase II neoadjuvant trial designed to select agents for phase III investigations...
  11. pmc A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer
    David J Hunter
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 39:870-4. 2007
    ..Our summary results from the GWAS are available online in a form that should speed the identification of additional risk loci...
  12. ncbi Obesity, body size, and risk of postmenopausal breast cancer: the Women's Health Initiative (United States)
    Libby M Morimoto
    Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Cancer Causes Control 13:741-51. 2002
    ....
  13. ncbi Estrogen plus progestin and colorectal cancer in postmenopausal women
    Rowan T Chlebowski
    Department of Medicine, Harbor UCLA Research and Education Institute, Torrance, Calif 90502, USA
    N Engl J Med 350:991-1004. 2004
    ..We analyzed features of the colorectal cancers that developed and their relation to the characteristics of the participants...
  14. ncbi Superior efficacy of letrozole versus tamoxifen as first-line therapy for postmenopausal women with advanced breast cancer: results of a phase III study of the International Letrozole Breast Cancer Group
    H Mouridsen
    Rigshospitalet, Copenhagen, Denmark
    J Clin Oncol 19:2596-606. 2001
    ..CONCLUSION: Letrozole was significantly superior to tamoxifen in TTP, TTF, ORR, and clinical benefit rate. Our results support its use as first-line endocrine therapy in postmenopausal women with advanced breast cancer...
  15. ncbi Phase III study of letrozole versus tamoxifen as first-line therapy of advanced breast cancer in postmenopausal women: analysis of survival and update of efficacy from the International Letrozole Breast Cancer Group
    Henning Mouridsen
    Rigshospitalet, Copenhagen, Denmark
    J Clin Oncol 21:2101-9. 2003
    ..To analyze overall survival (OS) and update efficacy data for letrozole versus tamoxifen as first-line therapy in postmenopausal women with locally advanced or metastatic breast cancer...
  16. ncbi Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial
    Sally A Shumaker
    Department of Public Health Sciences, Wake Forest University Health Sciences, Winston Salem, NC 27104, USA
    JAMA 289:2651-62. 2003
    ..On July 8, 2002, the study drugs, estrogen plus progestin, in the Women's Health Initiative (WHI) trial were discontinued because of certain increased health risks in women receiving combined hormone therapy...
  17. ncbi Suppression of plasma estrogen levels by letrozole and anastrozole is related to body mass index in patients with breast cancer
    Elizabeth J Folkerd
    Royal Marsden Hospital, London, United Kingdom
    J Clin Oncol 30:2977-80. 2012
    ....
  18. ncbi OPG and sRANKL serum concentrations in osteopenic, postmenopausal women after 2-year genistein administration
    Herbert Marini
    Department of Biochemical, Physiological and Nutritional Sciences, Section of Physiology and Human Nutrition, A O U Policlinico G Martino, Messina, Italy
    J Bone Miner Res 23:715-20. 2008
    ..Genistein, an isoflavone representing 1-5% of total phytoestrogen content in soybean products, may positively regulate cellular bone metabolism, but its mechanism of action on bone is not yet fully understood...
  19. pmc Vitamin D pathway gene polymorphisms, diet, and risk of postmenopausal breast cancer: a nested case-control study
    Marjorie L McCullough
    Epidemiology and Surveillance Research, American Cancer Society, 1599 Clifton Road NE, Atlanta, GA 30329, USA
    Breast Cancer Res 9:R9. 2007
    ..Whether risk is influenced by polymorphisms in other vitamin D metabolism genes and whether calcium or vitamin D intake modifies risk by genotype have not been evaluated...
  20. ncbi Body size and breast cancer risk: findings from the European Prospective Investigation into Cancer And Nutrition (EPIC)
    Petra H Lahmann
    Department of Epidemiology, German Institute of Human Nutrition, Potsdam Rehbrucke, Germany
    Int J Cancer 111:762-71. 2004
    ..Among premenopausal women, weight and BMI showed nonsignificant inverse associations with breast cancer...
  21. ncbi Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial
    Garnet L Anderson
    Fred Hutchinson Cancer Research Center, Seattle, Wash 98109 1024, USA
    JAMA 291:1701-12. 2004
    ..Despite decades of use and considerable research, the role of estrogen alone in preventing chronic diseases in postmenopausal women remains uncertain...
  22. ncbi Adjuvant tamoxifen and exemestane in early breast cancer (TEAM): a randomised phase 3 trial
    Cornelis J H Van De Velde
    Leiden University Medical Centre, Leiden, Netherlands
    Lancet 377:321-31. 2011
    ..We therefore compared the long-term effects of exemestane monotherapy with sequential treatment (tamoxifen followed by exemestane)...
  23. ncbi Prevalence and impact of vaginal symptoms among postmenopausal women
    Nanette Santoro
    Division of Reproductive Endocrinology, Albert Einstein College of Medicine, Ob Gyn and Women s Health, New York, NY 10461, USA
    J Sex Med 6:2133-42. 2009
    ..Vulvovaginal atrophy (VVA) is reported by one-quarter to one-half of postmenopausal women...
  24. ncbi Endometrial cancer and hormone-replacement therapy in the Million Women Study
    Valerie Beral
    Lancet 365:1543-51. 2005
    ..To minimise this risk, many HRT users who have not had a hysterectomy use combined oestrogen-progestagen preparations or tibolone. Limited information is available on the incidence of endometrial cancer in users of these therapies...
  25. ncbi Randomized trial of tamoxifen versus tamoxifen plus aminoglutethimide as adjuvant treatment in postmenopausal breast cancer patients with hormone receptor-positive disease: Austrian breast and colorectal cancer study group trial 6
    Marianne Schmid
    Medical Department, Graz University, and Second Department of Surgery, Graz Hospital, Graz, Austria
    J Clin Oncol 21:984-90. 2003
    ..To determine whether the addition of aminoglutethimide to tamoxifen is able to improve the outcome in postmenopausal patients with hormone receptor-positive, early-stage breast cancer...
  26. ncbi Serum 25-hydroxyvitamin D and risk of post-menopausal breast cancer--results of a large case-control study
    Sascha Abbas
    Division of Cancer Epidemiology, German Cancer Research Center, 69120 Heidelberg, Germany
    Carcinogenesis 29:93-9. 2008
    ....
  27. ncbi Genetic variation at the CYP19A1 locus predicts circulating estrogen levels but not breast cancer risk in postmenopausal women
    Christopher A Haiman
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA
    Cancer Res 67:1893-7. 2007
    ..Thus, although genetic variation in CYP19A1 produces measurable differences in estrogen levels among postmenopausal women, the magnitude of the change was insufficient to contribute detectably to breast cancer...
  28. ncbi Adult weight change and risk of postmenopausal breast cancer
    A Heather Eliassen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02115, USA
    JAMA 296:193-201. 2006
    ..Endogenous hormones are a primary cause of breast cancer. Adiposity affects circulating hormones, particularly in postmenopausal women, and may be a modifiable risk factor for breast cancer...
  29. ncbi Meta-analysis: effect of hormone-replacement therapy on components of the metabolic syndrome in postmenopausal women
    S R Salpeter
    Stanford University School of Medicine, Stanford, CA, USA
    Diabetes Obes Metab 8:538-54. 2006
    ..To quantify the effects of hormone-replacement therapy (HRT) on components of the metabolic syndrome in postmenopausal women...
  30. ncbi Postmenopausal serum androgens, oestrogens and breast cancer risk: the European prospective investigation into cancer and nutrition
    R Kaaks
    International Agency for Research on Cancer IARC WHO, Lyon, France
    Endocr Relat Cancer 12:1071-82. 2005
    ..The results from this study caution against the use of DHEA(S), or other androgens, for postmenopausal androgen replacement therapy...
  31. ncbi Risk of different histological types of postmenopausal breast cancer by type and regimen of menopausal hormone therapy
    Dieter Flesch-Janys
    Department of Medical Biometry and Epidemiology, Center for Experimental Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Int J Cancer 123:933-41. 2008
    ..These data suggest that the risks associated with menopausal HT differ by type and regimen of HT and histological type of breast cancer and may vary by progestagenic component, depending on the effective dose...
  32. pmc Circulating sex hormones and breast cancer risk factors in postmenopausal women: reanalysis of 13 studies
    T J Key
    Endogenous Hormones and Breast Cancer Collaborative Group, Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Richard Doll Building, Roosevelt Drive, Oxford OX3 7LF, UK
    Br J Cancer 105:709-22. 2011
    ..Breast cancer risk for postmenopausal women is positively associated with circulating concentrations of oestrogens and androgens, but the determinants of these hormones are not well understood...
  33. ncbi Outcomes ascertainment and adjudication methods in the Women's Health Initiative
    J David Curb
    Department of Geriatric Medicine, University of Hawaii, Honolulu, HI 96813, USA
    Ann Epidemiol 13:S122-8. 2003
  34. ncbi Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/progestin Replacement Study (HERS) Research Group
    S Hulley
    University of California, San Francisco 94143, USA
    JAMA 280:605-13. 1998
    ..However, given the favorable pattern of CHD events after several years of therapy, it could be appropriate for women already receiving this treatment to continue...
  35. pmc Relation between obesity and bone mineral density and vertebral fractures in Korean postmenopausal women
    Kyong Chol Kim
    Department of Family Medicine, MizMedi Hospital, Seoul, Korea
    Yonsei Med J 51:857-63. 2010
    ..Using a cross sectional study design, we evaluated the associations between obesity or metabolic syndrome and bone mineral density (BMD) or vertebral fracture...
  36. ncbi Vitamin D insufficiency and health outcomes over 5 y in older women
    Mark J Bolland
    Department of Medicine, University of Auckland, Auckland, New Zealand
    Am J Clin Nutr 91:82-9. 2010
    ..However, some studies did not control for confounding factors such as age or seasonal variation of 25-hydroxyvitamin D [25(OH)D]...
  37. pmc A vegetable-fruit-soy dietary pattern protects against breast cancer among postmenopausal Singapore Chinese women
    Lesley M Butler
    Department of Environmental, Colorado State University, Fort Collins, CO 80523 1681, USA
    Am J Clin Nutr 91:1013-9. 2010
    ..Prospective epidemiologic studies in Asian populations consistently show that soy is protective against breast cancer...
  38. pmc Changes in weight, waist circumference and compensatory responses with different doses of exercise among sedentary, overweight postmenopausal women
    Timothy S Church
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA
    PLoS ONE 4:e4515. 2009
    ..The goal of this analysis was to examine actual weight loss compared to predicted weight loss (compensation) across different doses of exercise in a controlled trial of sedentary, overweight or obese postmenopausal women (n = 411)...
  39. ncbi Association between lean mass and handgrip strength with bone mineral density in physically active postmenopausal women
    Rosangela Villa Marin
    Physical Fitness Research Center of São Caetano do Sul CELAFISCS, Sao Paulo, Brazil
    J Clin Densitom 13:96-101. 2010
    ..Our results suggest that strategies aiming to improve muscle strength and lean mass must contribute to the bone health of physically active postmenopausal women...
  40. ncbi Insulin-like growth factor-I, IGF-binding protein-3, and mammographic breast density
    Caroline Diorio
    Unité de recherche en santé des populations, Centre Hospitalier Affilie Universitaire De Quebec, Hôpital Saint Sacrement, 1050 Chemin Sainte Foy, Quebec, Quebec, Canada G1S 4L8
    Cancer Epidemiol Biomarkers Prev 14:1065-73. 2005
    ..They provide additional support for the idea that, among premenopausal women, these growth factors may affect breast cancer risk, at least in part, through their influence on breast tissue morphology as reflected on mammogram...
  41. ncbi Conformity to traditional Mediterranean diet and breast cancer risk in the Greek EPIC (European Prospective Investigation into Cancer and Nutrition) cohort
    Antonia Trichopoulou
    WHO Collaborating Center for Food and Nutrition Policies, Department of Hygiene, Epidemiology and Medical Statistics, Athens, Greece
    Am J Clin Nutr 92:620-5. 2010
    ..No study, however, has evaluated the association of the traditional Mediterranean diet with breast cancer in a Mediterranean country...
  42. ncbi Calcium plus vitamin D supplementation and the risk of fractures
    Rebecca D Jackson
    Division of Endocrinology, Ohio State University, 485 McCampbell, 1581 Dodd Dr, Columbus, OH 43210, USA
    N Engl J Med 354:669-83. 2006
    ..The efficacy of calcium with vitamin D supplementation for preventing hip and other fractures in healthy postmenopausal women remains equivocal...
  43. ncbi The Patient's Anastrozole Compliance to Therapy (PACT) Program: a randomized, in-practice study on the impact of a standardized information program on persistence and compliance to adjuvant endocrine therapy in postmenopausal women with early breast cance
    P Hadji
    Department of Gynecology, Endocrinology and Oncology, Phillips University of Marburg, Marburg, Germany
    Ann Oncol 24:1505-12. 2013
    ..Compliance and persistence are often overlooked in adjuvant breast cancer treatment...
  44. ncbi Postmenopausal sex hormones in relation to body fat distribution
    Stefanie Liedtke
    Unit of Environmental Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Obesity (Silver Spring) 20:1088-95. 2012
    ..On the whole, our results indicate that waist circumference and WHR, but not hip circumference, are associated with SHBG and SHBG-related sex hormones (free estradiol and free testosterone) independently of BMI...
  45. ncbi Long term hormone therapy for perimenopausal and postmenopausal women
    Jane Marjoribanks
    Obstetrics and Gynaecology, University of Auckland, Auckland, New Zealand
    Cochrane Database Syst Rev 7:CD004143. 2012
    ..This is an updated version of a Cochrane review first published in 2005...
  46. ncbi A randomized, placebo-controlled trial (NCIC CTG MAP.2) examining the effects of exemestane on mammographic breast density, bone density, markers of bone metabolism and serum lipid levels in postmenopausal women
    T Cigler
    Weill Cornell Medical College, New York, NY, USA
    Breast Cancer Res Treat 126:453-61. 2011
    ..Changes in lipid parameters on this trial were modest and reversible...
  47. pmc Obstetric history and mammographic density: a population-based cross-sectional study in Spain (DDM-Spain)
    Virginia Lope
    Cancer Epidemiology Unit, National Center of Epidemiology, Instituto de Salud Carlos III, Monforte de Lemos 5, 28029 Madrid, Spain
    Breast Cancer Res Treat 132:1137-46. 2012
    ..These results suggest the influence of hormones and growth factors over the proliferative activity of the mammary gland...
  48. ncbi Clinical review: DHEA replacement for postmenopausal women
    Susan R Davis
    Women s Health Research Program, Department of Epidemiology and Preventive Medicine, Monash University, 99 Commercial Road, Melbourne, Victoria 3004, Australia
    J Clin Endocrinol Metab 96:1642-53. 2011
    ..We have summarized the physiology of DHEA in women and reviewed the findings from randomized controlled trials (RCT) of the effects of DHEA therapy in postmenopausal women with normal adrenal function...
  49. pmc A food frequency questionnaire for the assessment of calcium, vitamin D and vitamin K: a pilot validation study
    Janet M Pritchard
    McMaster University, W Hamilton ON L8N 3Z5, Canada
    Nutrients 2:805-19. 2010
    ..This pilot study showed promising validation evidence for the use of this FFQ, which focuses on calcium, vitamin D and vitamin K intakes in postmenopausal women, as a screening tool in clinical and research settings...
  50. ncbi Vaginal Health: Insights, Views & Attitudes (VIVA) - results from an international survey
    R E Nappi
    Research Center for Reproductive Medicine, Gynecological Endocrinology and Menopause Unit, Department of Obstetrics and Gynecology, IRCCS S Matteo Foundation, University of Pavia, Pavia, Italy
    Climacteric 15:36-44. 2012
    ..To assess knowledge of vaginal atrophy among women using the Vaginal Health: Insights, Views & Attitudes (VIVA) survey...
  51. pmc Diabetes abrogates sex differences and aggravates cardiometabolic risk in postmenopausal women
    Filipa Mascarenhas-Melo
    Laboratory of Pharmacology and Experimental Therapeutics, IBILI, Faculty of Medicine, University of Coimbra, Azinhaga de Santa Comba, Celas, Coimbra, 3000 548, Portugal
    Cardiovasc Diabetol 12:61. 2013
    ..The aim of this study is to evaluate the effect of gender and menopause in cardiometabolic risk in a type 2 diabetes mellitus (T2DM) population, based on classical and non-traditional markers...
  52. pmc Markers of increased cardiovascular risk in postmenopausal women: focus on oxidized-LDL and HDL subpopulations
    Filipa Mascarenhas-Melo
    Laboratory of Pharmacology and Experimental Therapeutics, IBILI, Faculty of Medicine, University of Coimbra, 3000 548 Coimbra, Portugal
    Dis Markers 35:85-96. 2013
    ..To evaluate the effect of gender and menopause in cardiovascular risk (CVR) in a healthy population based on both classical and nontraditional markers...
  53. ncbi A metabolic phenotyping approach to understanding relationships between metabolic syndrome and breast tumour responses to chemotherapy
    J Stebbing
    Section of Oncology, Department of Surgery and Cancer, Faculty of Medicine, Imperial College, London, UK
    Ann Oncol 23:860-6. 2012
    ..To study this further, we examined the relationship between serum metabolite levels and the components of metabolic syndrome with treatment outcomes in breast cancer...
  54. ncbi Natural S-equol decreases bone resorption in postmenopausal, non-equol-producing Japanese women: a pilot randomized, placebo-controlled trial
    Yuko Tousen
    Food Function and Labeling Program, National Institute of Health and Nutrition, Tokyo, Japan
    Menopause 18:563-74. 2011
    ..However, results from clinical trials have not been published. The aim of this study was to investigate the effects of equol on bone metabolism and serum sex and thyroid hormone levels in postmenopausal Japanese women...
  55. ncbi Roles of androgens in the development, growth, and carcinogenesis of the mammary gland
    Dezhong J Liao
    Department of Oncology, Lombardi Cancer Center, Georgetown University Medical Center Research Building, W416, 3970 Reservoir Road NW, Washington, DC 20007, USA
    J Steroid Biochem Mol Biol 80:175-89. 2002
    ....
  56. ncbi A menopause-specific quality of life questionnaire: development and psychometric properties
    J R Hilditch
    Department of Family and Community Medicine, Sunnybrook Health Science Centre, University of Toronto, North York, Ontario, Canada
    Maturitas 24:161-75. 1996
    ....
  57. pmc Postmenopausal hypertension
    Licy L Yanes
    Women s Health Research Center, University of Mississippi Medical Center, Jackson, Mississippi, USA
    Am J Hypertens 24:740-9. 2011
    ....
  58. pmc Insulin, insulin-like growth factor-I, endogenous estradiol, and risk of colorectal cancer in postmenopausal women
    Marc J Gunter
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 68:329-37. 2008
    ....
  59. pmc Identification of common variants in the SHBG gene affecting sex hormone-binding globulin levels and breast cancer risk in postmenopausal women
    Deborah J Thompson
    Cambridge University, Strangeways Research Laboratories, Worts Causeway, Cambridge CB1 8RN, United Kingdom
    Cancer Epidemiol Biomarkers Prev 17:3490-8. 2008
    ..Three polymorphisms within the SHBG gene have been reported to affect SHBG levels, but there has been no systematic attempt to identify other such variants...
  60. pmc Effect of hormone therapy on lean body mass, falls, and fractures: 6-year results from the Women's Health Initiative hormone trials
    Jennifer W Bea
    Arizona Cancer Center, Tucson, AZ 85724 5024, USA
    Menopause 18:44-52. 2011
    ....
  61. pmc Greater endogenous estrogen exposure is associated with longer telomeres in postmenopausal women at risk for cognitive decline
    Jue Lin
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94118, USA
    Brain Res 1379:224-31. 2011
    ..The results suggest that the endogenous estrogens may be associated with deceleration of cellular aging. This is the first study to examine associations between endogenous estrogens, telomere length and telomerase activity...
  62. ncbi Serum adiponectin, bone mineral density and bone turnover markers in post-menopausal women with newly diagnosed Type 2 diabetes: a 12-month follow-up
    T Miazgowski
    Department of Hypertension and Internal Medicine, Pomeranian Medical University, Szczecin, Poland
    Diabet Med 29:62-9. 2012
    ....
  63. pmc Diabetes, metformin, and breast cancer in postmenopausal women
    Rowan T Chlebowski
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
    J Clin Oncol 30:2844-52. 2012
    ..Therefore, we assessed associations among diabetes, metformin use, and breast cancer in postmenopausal women participating in Women's Health Initiative clinical trials...
  64. ncbi Mammographic density, response to hormones, and breast cancer risk
    Norman F Boyd
    DSC, Ontario Cancer Institute, 610 University Ave, Room 10 415, Toronto, Ontario, Canada
    J Clin Oncol 29:2985-92. 2011
    ..We have examined the magnitude of the association of hormone exposure with PMD according to subsequent breast cancer risk...
  65. pmc The soy isoflavones for reducing bone loss (SIRBL) study: a 3-y randomized controlled trial in postmenopausal women
    D Lee Alekel
    Nutrition and Wellness Research Center, Department of Food Science and Human Nutrition, Iowa State University, Ames, IA 50010 8281, USA
    Am J Clin Nutr 91:218-30. 2010
    ..Our previous study indicated that soy protein with isoflavones lessened lumbar spine bone loss in midlife women...
  66. ncbi Interaction between menopausal status and obesity in affecting breast cancer risk
    David P Rose
    Department of Surgery, Mary Babb Randolph Cancer Center, West Virginia University Robert C Byrd Health Sciences Center, Morgantown, WV 26506, USA
    Maturitas 66:33-8. 2010
    ....
  67. ncbi Obesity and fractures in postmenopausal women
    Melissa Orlandin Premaor
    Department of Medicine, University of Cambridge, Cambridge, United Kingdom
    J Bone Miner Res 25:292-7. 2010
    ....
  68. ncbi Aromatase inhibitors in the treatment of severe endometriosis
    Noha A Mousa
    Institute of Medical Science, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    Obstet Gynecol 109:1421-3. 2007
    ..Endometriosis-associated chronic pelvic pain unresponsive to surgical menopause is a difficult clinical problem...
  69. pmc Relationship between caffeine intake and plasma sex hormone concentrations in premenopausal and postmenopausal women
    Joanne Kotsopoulos
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer 115:2765-74. 2009
    ..Caffeine intake may decrease risk of breast and ovarian cancer, although the data are not entirely consistent. Whether or not caffeine affects cancer risk by altering sex hormone levels is currently unknown...
  70. ncbi A prospective study of body size and breast cancer in black women
    Julie R Palmer
    Slone Epidemiology Center at Boston University, 1010 Commonwealth Avenue, Boston, MA 02215, USA
    Cancer Epidemiol Biomarkers Prev 16:1795-802. 2007
    ....
  71. ncbi Vitamin D status in relation to obesity, bone mineral density, bone turnover markers and vitamin D receptor genotypes in healthy Saudi pre- and postmenopausal women
    M S M Ardawi
    Center of Excellence for Osteoporosis Research, King Abdulaziz University, P O Box No 20724, Jeddah, 21465, Saudi Arabia
    Osteoporos Int 22:463-75. 2011
    ..Vitamin D deficiency was highly prevalent among studied Saudi women with obesity, poor sunlight exposure, poor dietary vitamin D supplementation and age as the main risk factors...
  72. ncbi A randomized trial of letrozole in postmenopausal women after five years of tamoxifen therapy for early-stage breast cancer
    Paul E Goss
    Division of Hematology Oncology, Princess Margaret Hospital, Toronto, ON, Canada
    N Engl J Med 349:1793-802. 2003
    ..The aromatase inhibitor letrozole, by suppressing estrogen production, might improve the outcome after the discontinuation of tamoxifen therapy...
  73. ncbi Walking compared with vigorous exercise for the prevention of cardiovascular events in women
    JoAnn E Manson
    Division of Preventive Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston 02215, USA
    N Engl J Med 347:716-25. 2002
    ..The role of walking, as compared with vigorous exercise, in the prevention of cardiovascular disease remains controversial. Data for women who are members of minority racial or ethnic groups are particularly sparse...
  74. ncbi Postmenopausal breast cancer risk and dietary patterns in the E3N-EPIC prospective cohort study
    Vanessa Cottet
    Institut National de la Sante et de la Recherche Medicale INSERM, Equipe Région INSERM 20, Institut de Cancerologie Gustave Roussy, Villejuif, France
    Am J Epidemiol 170:1257-67. 2009
    ..Adherence to a diet comprising mostly fruits, vegetables, fish, and olive/sunflower oil, along with avoidance of Western-type foods, may contribute to a substantial reduction in postmenopausal breast cancer risk...
  75. ncbi Seasonal changes in vitamin D status and bone turnover in healthy Irish postmenopausal women
    Tom R Hill
    Department of Food and Nutritional Sciences, University College, Cork, Ireland
    Int J Vitam Nutr Res 77:320-5. 2007
    ..To examine the effect of season on biochemical markers of bone turnover in 51-to 75-year-old Irish women and to investigate whether such changes are related to vitamin D status...
  76. ncbi Adiposity, adult weight change, and postmenopausal breast cancer risk
    Jiyoung Ahn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, EPS, 6120 Executive Blvd, Bethesda, MD 20892, USA
    Arch Intern Med 167:2091-102. 2007
    ..Obesity is a risk factor for postmenopausal breast cancer, but the role of the timing and amount of adult weight change in breast cancer risk is unclear...
  77. ncbi Polymorphisms associated with circulating sex hormone levels in postmenopausal women
    Alison M Dunning
    Cancer Research UK, Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK
    J Natl Cancer Inst 96:936-45. 2004
    ..We investigated the association between levels of sex hormones and single nucleotide polymorphisms (SNPs) in genes coding for the enzymes that regulate them...
  78. ncbi Estrogen replacement increased the citrate and calcium excretion rates in postmenopausal women with recurrent urolithiasis
    Jayant Dey
    Department of Endocrinology, Ochsner Clinic, Tulane University, New Orleans, Louisiana, USA
    J Urol 167:169-71. 2002
    ..We investigated the role of menopausal estrogen replacement therapy on the urinary constituents and characteristics that may influence recurrent calcium oxalate stone disease...
  79. ncbi Relationship of serum adiponectin with blood lipids, HbA(1)c, and hs-CRP in type II diabetic postmenopausal women
    Mohammad Taghi Goodarzi
    Department of Biochemistry and Nutrition, Medical School, Hamadan University of Medical Sciences, Hamadan, Iran
    J Clin Lab Anal 21:197-200. 2007
    ..Adiponectin may play an important role in the pathogenesis of diabetes, and may be an independent predictor of the development of diabetes in women...
  80. ncbi Standardization of bone mineral density at femoral neck, trochanter and Ward's triangle
    Y Lu
    Department of Radiology, University of California, San Francisco 94143 0628, USA
    Osteoporos Int 12:438-44. 2001
    ..The subregion calibration formulas are most appropriate for calibrating subregion BMD values and their absolute changes, and should be adopted. Standardization is unnecessary for BMD percentage changes in our clinical trial data...
  81. ncbi Human cultured skin fibroblasts express estrogen receptor alpha and beta
    Jozef Haczynski
    Eli Lilly, Medical Department Poland, 01 698 Warszawa, Poland
    Int J Mol Med 10:149-53. 2002
    ..The dominant expression of ER-beta in cultured female skin fibroblasts suggests that ER-beta may play a dominant role in collaboration with ER-alpha in the regulation of estrogen action in skin...
  82. pmc Comprehensive analysis of hormone and genetic variation in 36 genes related to steroid hormone metabolism in pre- and postmenopausal women from the breast and prostate cancer cohort consortium (BPC3)
    L Beckmann
    Division of Cancer Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany
    J Clin Endocrinol Metab 96:E360-7. 2011
    ..Sex steroids play a central role in breast cancer development...
  83. ncbi Metabolic implications of menopause
    Hanah N Polotsky
    Weill Cornell Medical Center and Memorial Sloan Kettering Cancer Center, New York 10065, USA
    Semin Reprod Med 28:426-34. 2010
    ..This review focuses on metabolic changes associated with menopausal transition, specifically alterations in weight, waist circumference, body fat distribution, energy expenditure, and circulating biomarkers including adipokines...
  84. pmc Deciphering normal blood gene expression variation--The NOWAC postgenome study
    Vanessa Dumeaux
    Institute of Community Medicine, University of Tromsø, Tromsø, Norway
    PLoS Genet 6:e1000873. 2010
    ....
  85. ncbi Body mass index and physical activity in relation to the incidence of hip fracture in postmenopausal women
    Miranda E G Armstrong
    Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom
    J Bone Miner Res 26:1330-8. 2011
    ..68 (95% CI 0.62-0.75), with similar results for strenuous exercise. In this large cohort of postmenopausal women, BMI and physical activity had independent effects on hip fracture risk...
  86. ncbi Optimizing endocrine therapy for breast cancer
    Eric P Winer
    J Clin Oncol 23:1609-10. 2005
  87. ncbi Double-blind, randomized placebo controlled trial of fulvestrant compared with exemestane after prior nonsteroidal aromatase inhibitor therapy in postmenopausal women with hormone receptor-positive, advanced breast cancer: results from EFECT
    Stephen Chia
    Division of Medical Oncology, British Columbia Cancer Agency, University of British Columbia, 600 West 10 Avenue, Vancouver, BC, Canada
    J Clin Oncol 26:1664-70. 2008
    ..Because many patients subsequently experience progression or relapse, it is important to identify agents with efficacy after AI failure...
  88. ncbi Meta-analysis of walking for preservation of bone mineral density in postmenopausal women
    Marrissa Martyn-St James
    Carnegie Faculty of Sport and Education, Leeds Metropolitan University, Room 202, Fairfax Hall, Headingley Campus, Leeds LS6 3QT, UK
    Bone 43:521-31. 2008
    ..Other forms of exercise that provide greater targeted skeletal loading may be required to preserve bone mineral density in this population...
  89. ncbi Prospective study to assess short-term intra-articular and tenosynovial changes in the aromatase inhibitor-associated arthralgia syndrome
    Leilani Morales
    Department of Obstetrics and Gynecology, Division of Gynecological Oncology, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    J Clin Oncol 26:3147-52. 2008
    ..To date, its exact mechanism remains unclear. The purpose of this study was to investigate the changes in clinical rheumatologic features and magnetic resonance imaging (MRI) of hands and wrists in AI and tamoxifen users...
  90. pmc Alberta physical activity and breast cancer prevention trial: sex hormone changes in a year-long exercise intervention among postmenopausal women
    Christine M Friedenreich
    Alberta Health Services, Calgary, Alberta, Canada
    J Clin Oncol 28:1458-66. 2010
    ....
  91. ncbi Successful treatment of an aggressive recurrent post-menopausal endometriosis with an aromatase inhibitor
    H M Fatemi
    Centre of Reproductive Medicine, AZ VUB, University Hospital, Dutch speaking Free University of Brussels, Laarbeeklaan 101, 1090 Brussels, Belgium
    Reprod Biomed Online 11:455-7. 2005
    ..Medical management of recurrent post-menopausal endometriosis with aromatase inhibitors seems to be an effective alternative treatment to surgery...
  92. ncbi Prospective cohort study of soy food consumption and risk of bone fracture among postmenopausal women
    Xianglan Zhang
    Department of Medicine, Center for Health Services Research, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tenn 37232 8300, USA
    Arch Intern Med 165:1890-5. 2005
    ..Soy consumption has been shown to modulate bone turnover and increase bone mineral density in postmenopausal women. To our knowledge, no published studies have directly examined the association between soy consumption and risk of fracture...
  93. ncbi The underlying basis for obesity: relationship to cancer
    George A Bray
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    J Nutr 132:3451S-3455S. 2002
    ..Efforts to control obesity through preventive strategies and treatment can be expected to have a benefit in reducing the risk of cancer...
  94. ncbi High-fiber rye bread and insulin secretion and sensitivity in healthy postmenopausal women
    Katri S Juntunen
    Department of Clinical Nutrition, University of Kuopio, Kuopio, Finland
    Am J Clin Nutr 77:385-91. 2003
    ..Fiber and whole-cereal intakes may protect against hyperinsulinemia and the risk of type 2 diabetes...
  95. ncbi Effects of isoflavone and exercise on BMD and fat mass in postmenopausal Japanese women: a 1-year randomized placebo-controlled trial
    Jian Wu
    Division of Applied Food Research, National Institute of Health and Nutrition, Tokyo, Japan
    J Bone Miner Res 21:780-9. 2006
    ..The combined intervention of isoflavone intake and walking exercise over 1 year in postmenopausal Japanese women exhibited a trend for a greater effect on prevention of bone loss at the total hip and Ward's triangle regions...
  96. ncbi A clinical trial of estrogen-replacement therapy after ischemic stroke
    C M Viscoli
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Conn. 06520-8056, USA
    N Engl J Med 345:1243-9. 2001
    ..CONCLUSIONS: Estradiol does not reduce mortality orthe recurrence of stroke in postmenopausal women with cerebrovascular disease. This therapy should not be prescribed for the secondary prevention of cerebrovascular disease...
  97. ncbi Dietary intake of phytoestrogens is associated with a favorable metabolic cardiovascular risk profile in postmenopausal U.S.women: the Framingham study
    Miriam J J de Kleijn
    Julius Center for General Practice and Patient Oriented Research, University Medical Center, Utrecht, The Netherlands
    J Nutr 132:276-82. 2002
    ..55 points (95% CI, -0.82 to -0.28). In conclusion, high intake of phytoestrogens in postmenopausal women appears to be associated with a favorable metabolic cardiovascular risk profile...
  98. ncbi Ratio of 17HSD1 to 17HSD2 protein expression predicts the outcome of tamoxifen treatment in postmenopausal breast cancer patients
    Agneta Jansson
    Department of Clinical and Experimental Medicine, Division of Oncology, Linkoping University, Linkoping, Sweden
    Clin Cancer Res 15:3610-6. 2009
    ..The aim of this study was to investigate the prognostic and tamoxifen predictive values of 17HSD1 and 17HSD2 expression...
  99. ncbi Metabolic syndrome after menopause and the role of hormones
    Rogerio A Lobo
    Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, NY 10032, United States
    Maturitas 60:10-8. 2008
    ..The purpose of this review is to focus on the importance of metabolic syndrome (MBS) and its increased prevalence in postmenopausal (PM) women. Also the role of hormonal therapy in PM women with MBS will be discussed...
  100. ncbi Physical activity and postmenopausal breast cancer: proposed biologic mechanisms and areas for future research
    Heather K Neilson
    Division of Population Health, Alberta Cancer Board, 1331 29 Street NW, Calgary, Alberta, Canada T2N 4N2
    Cancer Epidemiol Biomarkers Prev 18:11-27. 2009
    ..Future etiologic studies should consider interactions among biomarkers, whereas exercise trials should explore exercise effects independently of weight loss, different exercise prescriptions, and effects on central adiposity...
  101. ncbi Body weight and incidence of breast cancer defined by estrogen and progesterone receptor status--a meta-analysis
    Reiko Suzuki
    Institute of Environmental Medicine, Division of Nutritional Epidemiology, Karolinska Institutet, Stockholm, Sweden
    Int J Cancer 124:698-712. 2009
    ..The relation between body weight and breast cancer risk is critically dependent on the tumor's ER/PR status and the woman's menopausal status. Body weight control is the effective strategy for preventing ER+PR+ tumors after menopause...

Research Grants62

  1. Sex Hormones in Postmenopausal Women in the Diabetes Prevention Program
    Catherine Kim; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Although postmenopause is a universal experience of aging and is defined by permanent changes in ovarian function, we still do not understand how postmenopausal sex hormones affect diabetes risk...
  2. Epistasis in Steroidogenic Genes in the Prediction of Alzheimer's Disease
    CRAIG STEPHEN ATWOOD; Fiscal Year: 2013
    ..Successful completion of these studies would enable the development of prognostic and diagnostic tests for AD, and provide insights into the neuroendocrine mechanisms of AD. ..
  3. Estrogen, Aging and Vascular Inflammation
    Anne A Knowlton; Fiscal Year: 2013
    ..Although the work focuses on estrogen and EETs, it will provide new insights and potentially new therapies (sEH inhibitors) vascular disease, which can help both male and female veterans. ..
  4. STRAW+10: Addressing the Unfinished Agenda of Staging Reproductive Aging - RESUBM
    Sioban D Harlow; Fiscal Year: 2011
    ..We also propose to extend the STRAW recommendations to be more broadly applicable to the range of women's diverse experience of reproductive aging. ..
  5. Endothelial SK3 Channel Modulation of EDHF is Estrogen Regulated
    Mike T Lin; Fiscal Year: 2011
    ..This proposal is designed to test the hypothesis that estrogen regulates endothelial potassium channels to modulate vascular reactivity and blood pressure.) ..
  6. Epidemiology of lens aging in older women
    JASON LEIGH SANDERS; Fiscal Year: 2013
    ..just refunded for a 4th examination of the determinants of risk factor changes among women during peri- and postmenopause. To capitalize on the wealth of information obtained in the HWS during the current study cycle, we will add a ..
  7. Study of Women's Health Across the Nation V: Endocrinology/CLASS Laboratory
    Daniel S McConnell; Fiscal Year: 2013
    ..new areas of endocrine importance, and extend the study of hormonal characteristics from the early to late postmenopause. We will challenge the traditional concept of the menopausal transition as simply a loss of ovarian estradiol ..
  8. Regulation of GPER-mediated Signaling in the Vasculature by Calmodulin
    Kim Tran; Fiscal Year: 2012
    ..It is expected that the proposed studies will provide timely information that help form the basis for targeting estrogen receptor subtypes for preventive and therapeutic purposes. ..
  9. Beyond Adiposity: Insulin and Inflammation in Postmenopausal Breast Cancer
    Nomeli Nunez; Fiscal Year: 2009
    ..The K-22 career development award will enable the candidate to establish an academic laboratory that will focus on elucidating the roles of adipose tissue and insulin resistance in breast cancer development. ..
  10. Yoga and Cardiovascular Disease Risk in Older Women
    KAREN KIM E INNES; Fiscal Year: 2012
    ..potential utility of a safe, inexpensive intervention in reducing CVD risk in both diabetic and healthy women postmenopause. If findings are positive and confirmed in other, larger studies, the use of yoga as a therapeutic ..
  11. Iron and Atherosclerosis
    Subha V Raman; Fiscal Year: 2013
    ..This research tests the theory that monthly loss of iron through menses is protective against atherosclerosis, which could lead to an entirely new approach to preventing and treating heart and vascular disease in both men and women. ..
  12. Study of Women's Health Across the NationIV: Chicago Site
    Howard M Kravitz; Fiscal Year: 2013
    ..characterization to date of the health and the physiologic and psychosocial changes of women from pre- to postmenopause in community based samples...
  13. Prevention of Menopause-Related Ovarian Epithelial Cancer
    Elizabeth R Smith; Fiscal Year: 2010
    ..The goal is to formulate rationale preventive strategies for ovarian cancer in post-menopausal women. ..
  14. Involvement of Leptin and Interleukin-1 Signaling in Mammary Cancer Progression
    RUBEN RENE GONZALEZ-PEREZ; Fiscal Year: 2012
    ..Inhibition of leptin signaling in such instances might serve as a preventative or adjuvant measure. ..
  15. Study of Women's Health Across the Nation IV: UCLA Site
    Gail A Greendale; Fiscal Year: 2013
    ..characterization to date of the health and the physiologic and psychosocial changes of women from pre- to postmenopause in community based samples...
  16. SWAN: Study of Women's Health Across the Nation
    Joel S Finkelstein; Fiscal Year: 2013
    ..characterization to date of the health and the physiologic and psychosocial changes of women from pre- to postmenopause in community based samples...
  17. Ethanol discrimination in aged female monkeys
    Christa M Helms; Fiscal Year: 2010
    ....
  18. Role of the Follicle-Depleted Ovary in the Pathogenesis of Chronic Diseases
    Susan E Appt; Fiscal Year: 2012
    ..The existing gaps in knowledge surrounding the perimenopausal transition and postmenopause prompted us to propose the following four Specific Aims: 1) Determine the extent to which diet induced ..
  19. Prolactin as a lacrimal gland immunomodulator
    Joel Schechter; Fiscal Year: 2009
    ..Specific Aim 4 tests the hypothesis that homeostatic states associated with certain endocrine settings cause desiccation or trauma at the ocular surface to elicit exaggerated inflammatory responses ..
  20. Estrogen receptor beta protein:protein interactions following estrogen withdrawal
    NATASHA MOTT; Fiscal Year: 2013
    ..Overall, this proposal will reveal molecular mechanisms occurring during estrogen withdrawal that may alter the brain's receptivity to HT. ..
  21. Study of Women's Health Across the Nation - Coordinating Center
    Maria Mori Brooks; Fiscal Year: 2013
    ..characterization to date of the health and the physiologic and psychosocial changes of women from pre- to postmenopause in community based samples...
  22. Defining the Mechanisms of Menopause-Associated Sleep and Mood Disturbances
    Hadine Joffe; Fiscal Year: 2013
    ..Women are at increased risk for insomnia and depression during the perimenopause and early postmenopause. Hot flashes have been linked to menopause-associated insomnia and depression, but the biological basis of ..
  23. Restoration of Estradiol Effects on Learning by Cholinergic Enhancement
    Robert Gibbs; Fiscal Year: 2009
    ....
  24. Impact of Endocrine Aging on Brain and Immune Responses
    Farida Sohrabji; Fiscal Year: 2010
    ..irregularly cycling (perimenopause) and reproductive senescent (postmenopause). In Specific Aim 1...
  25. Viscoelastic deformation of bone matrix in postmenopause
    Do Gyoon Kim; Fiscal Year: 2010
    ..The outcomes of this project will contribute to the development of more effective therapies for treating osteoporosis associated with estrogen deficiency in postmenopausal patients. ..
  26. Estrogen Effects on Cholinergic Function in Older Women
    Paul A Newhouse; Fiscal Year: 2013
    ..g. neuroimaging). The over arching goal is to develop information to allow the development of models to potentially predict which women may benefit from the cognitive effects of estradiol after menopause. ..
  27. Neurobiology of the Menopausal Transition
    Yolanda R Smith; Fiscal Year: 2010
    ..years, stratified into panels representing premenopause, early perimenopause, late perimenopause and natural postmenopause defined by follicle-stimulating hormone levels and menstrual bleeding patterns...
  28. Atherosclerosis Stage, Estrogen Receptors, and Vascular Responses to Estrogen
    THOMAS COSTIN REGISTER; Fiscal Year: 2010
    ....
  29. Dry Eye in Postmenopause
    Kelly K Nichols; Fiscal Year: 2011
    ..This project is a unique blend of interdisciplinary clinical and basic research, which may lead to the translation of findings to clinical care in dry eye disease. ..
  30. Metabolic Syndrome as Women Undergo Menopausal Transition: A Multi-Ethnic Study
    JENNIFER SHUWEN LEE; Fiscal Year: 2012
    ..Both our aims bear directly on this wider objective. These would impact 60+ million midlife and older U.S. women. ..
  31. Menopause Symptom Clusters: Refocusing Therapeutics
    Nancy Fugate Woods; Fiscal Year: 2011
    ..symptom clusters during the late reproductive stage, early and late menopausal transition stages, and early postmenopause using latent class analysis;2) determine the consistency of symptom clusters as women change from one ..
  32. Hot flashes and memory dysfunction in the perimenopause
    MIRIAM T WEBER; Fiscal Year: 2013
    ..and night sweats) are a mechanism for memory changes in the transition from premenopause to perimenopause to postmenopause. The menopausal transition (MT) is associated with subtle declines in processing speed, motor function, verbal ..
  33. MENOPAUSE AND MIDLIFE AGING EFFECTS ON SLEEP DISORDERS
    Terry Young; Fiscal Year: 2006
    ....
  34. EPIDEMIOLOGY OF HORMONES AND OSTEOPOROSIS
    Lewis Kuller; Fiscal Year: 1991
    ..We will test the hypothesis that both cortical and trabecular bone are primarily determined by dietary intake of calcium during periods of increasing and stable bone mass and the levels of endogenous estrogens in the blood...
  35. TAMOXIFEN AND RETINOIC ACID EFFECT ON THE UTERUS
    Kenneth Nephew; Fiscal Year: 2000
    ..An understanding of the mechanism of action of tamoxifen and 4-HPR on uterine epithelia is of interest and of the utmost relevance to the evaluation of tamoxifen as a chemopreventive regimen for breast cancer. ..
  36. MELATONIN FOR AGE-RELATED SLEEP DISTURBANCE IN WOMEN
    Patricia Murphy; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  37. Progestin Levels and Inflammation in Postmenopause
    Peifeng Hu; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  38. SLEEP IN OLDER WOMEN--EFFECTS OF ESTROGEN
    KAREN MOE; Fiscal Year: 2001
    ..This study is the first step in a research program investigating the relationship between sex steroids and sleep in older individuals. ..
  39. HORMONE REPLACEMENT AND METABOLIC CARDIOVASCULAR RISK
    Cynthia Sites; Fiscal Year: 2003
    ..In addition, our study may allow physicians to target hormone replacement to women with specific body compositions. ..
  40. Sex Steroids & Mammographic Density in the Postmenopause
    Gail Greendale; Fiscal Year: 2007
    ..This application proposes to continue work in "Sex Steroids and Mammographic Density in the Postmenopause", a study of the effects of endogenous and exogenous sex steroids on mammographic percent-density...
  41. POSTMENOPAUSAL HORMONE THERAPY AND INTRA ABDOMINAL FAT
    Barbara Gower; Fiscal Year: 2000
    ..Significance: HRT reduces risk and incidence of CVD in postmenopausal women. This study will determine if HRT reduces disease risk by influencing fat distribution and decreasing IAF. ..
  42. ESTROGEN, MUSCLE BLOOD FLOW AND ENOS POST MENOPAUSE
    Robert Hickner; Fiscal Year: 2000
    ..These investigations will provide valuable research exposure to our undergraduate and graduate programs, and will provide data for subsequent R01 applications. ..
  43. MENOPAUSE TRANSITION, MENTAL HEALTH, AND ETHNICITY
    Howard Kravitz; Fiscal Year: 2000
    ..abstract_text> ..
  44. AGE, PSYCHOSEXUAL RESPONSE, AND REPRODUCTIVE HORMONES
    Patricia Morokoff; Fiscal Year: 1990
    ..surgical menopause, and those who are 1-2 vs. 5-10 years postmenopause. It is believed that women in these groups will show differential responses to hormone replacement therapy ..
  45. MENOPAUSE TRANSITION, MENTAL HEALTH AND ETHNICITY
    Adriana Cordal; Fiscal Year: 2000
    ..abstract_text> ..
  46. Postmenopause CHD risk: Platelet genes & hormone therapy
    Paul Bray; Fiscal Year: 2006
    ..abstract_text> ..
  47. Differentiation and Proliferation of Human Osteoblasts
    Olivia Pereira Smith; Fiscal Year: 2001
    ..We will also determine whether osteoblasts can form tissue in a transplatation model system in vivo. The results will provide the preliminary data and evidence that we can perform these techniques for an R01 proposal. ..
  48. CLINICAL TRIAL CARDIOVASCULAR RISK FACTORS AND MENOPAUSE
    Lewis Kuller; Fiscal Year: 1999
    ..There were no significant changes in bone mineral density at either the 6 or 18 months visits in either group, and the intervention has positively affected depressive mood and menopausal symptoms. ..
  49. ERT, DEPRESSION AND COGNITION IN POSTMENOPAUSAL WOMEN
    Natalie Rasgon; Fiscal Year: 2002
    ..Existing data suggest that estrogen replacement therapy (ERT) in postmenopause enhances both mood-related symptoms and cognitive function...
  50. Mid-life Aging and Urinary Incontinence in a Multi-Ethn*
    L Waetjen; Fiscal Year: 2009
    ..abstract_text> ..
  51. SARCOPENIA AND ERT IN POSTMENOPAUSAL WOMEN
    Jane Kent Braun; Fiscal Year: 2000
    ..They will then test Hypotheses #3A: Intramuscular fat content will be lower in ERT compared to control and #3B: Intramuscular fat content will be related to physical activity level, regardless of estrogen status. ..
  52. Mechanisms of Exercise & Estrogen Induced Cytoprotection
    Karyn Hamilton; Fiscal Year: 2009
    ..These studies will improve our understanding of the mechanisms of exercise-induced cytoprotection, perhaps leading to alternative therapies for decreasing mortality from heart disease. ..
  53. EFFECT OF ESTROGEN ON FEMORAL NECH BONE MASS
    Michael Kleerekoper; Fiscal Year: 1993
    ..Of particular importance is an assessment of whether chronologic age or years postmenopause is a more specific determinant of the "age-related" decline in bone mass and bone strength, and the ..
  54. Hormone Status Postmenopause: Colonic Bacterial Effects
    Johanna Lampe; Fiscal Year: 2003
    ..The results of this study will provide novel data regarding the relationship of the equol-producer phenotype, a marker of colonic nticrofloral environment, to lifetime estrogen exposure. ..
  55. Yoga and Indices of Cardiovascular Risk in Older Women
    KAREN KIM INNES; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  56. Raloxifene in Women with AD: Randomized Controlled Trial
    VICTOR HENDERSON; Fiscal Year: 2007
    ..It is anticipated that findings from this pilot study will provide useful guidance to plan and conduct future studies of raloxifene in women with mild to moderate symptoms of dementia due to AD. ..
  57. DOXYCYCLINE FOR BLEEDING IN PROGESTIN ONLY CONTRACEPTORS
    David Archer; Fiscal Year: 2006
    ..If successful, DOX treatment could become an important adjuvant for treatment of this and possibly other inflammatory disorders effecting reproductive tract tissues. ..
  58. SWAN Sleep Study II - Michigan Center
    MaryFran Sowers; Fiscal Year: 2008
    ..the transition; and 4) adverse effects of sleep disturbances on subsequent health status during the early postmenopause (worsening metabolic profile and quality of life, increased hypertension, physical limitations)...
  59. Change in Bone, Arthritis, Function: Hormones & Obesity
    MaryFran Sowers; Fiscal Year: 2009
    ..yearly assessments will cover a 13-year period that includes the reproductive life span of women to the postmenopause. Annual assessments will include BMD, measures of physical functioning, phlebotomy and urine collection to ..