postmenopause

Summary

Summary: The physiological period following the MENOPAUSE, the permanent cessation of the menstrual life.

Top Publications

  1. ncbi Effect of exercise on total and intra-abdominal body fat in postmenopausal women: a randomized controlled trial
    Melinda L Irwin
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Conn, USA
    JAMA 289:323-30. 2003
  2. ncbi Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial
    Jacques E Rossouw
    Division of Women s Health Initiative, National Heart, Lung, and Blood Institute, 6705 Rockledge Dr, One Rockledge Ctr, Suite 300, Bethesda, MD 20817
    JAMA 288:321-33. 2002
  3. ncbi Pooled analysis of prospective cohort studies on height, weight, and breast cancer risk
    P A van den Brandt
    Department of Epidemiology, Maastricht University, The Netherlands
    Am J Epidemiol 152:514-27. 2000
  4. pmc Insulin, insulin-like growth factor-I, and risk of breast cancer in postmenopausal women
    Marc J Gunter
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, New York, NY 10461, USA
    J Natl Cancer Inst 101:48-60. 2009
  5. pmc A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer
    David J Hunter
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 39:870-4. 2007
  6. ncbi Estrogen plus progestin and colorectal cancer in postmenopausal women
    Rowan T Chlebowski
    Department of Medicine, Harbor UCLA Research and Education Institute, Torrance, Calif 90502, USA
    N Engl J Med 350:991-1004. 2004
  7. ncbi Obesity, body size, and risk of postmenopausal breast cancer: the Women's Health Initiative (United States)
    Libby M Morimoto
    Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Cancer Causes Control 13:741-51. 2002
  8. ncbi Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial
    Garnet L Anderson
    Fred Hutchinson Cancer Research Center, Seattle, Wash 98109 1024, USA
    JAMA 291:1701-12. 2004
  9. ncbi OPG and sRANKL serum concentrations in osteopenic, postmenopausal women after 2-year genistein administration
    Herbert Marini
    Department of Biochemical, Physiological and Nutritional Sciences, Section of Physiology and Human Nutrition, A O U Policlinico G Martino, Messina, Italy
    J Bone Miner Res 23:715-20. 2008
  10. ncbi Body size and breast cancer risk: findings from the European Prospective Investigation into Cancer And Nutrition (EPIC)
    Petra H Lahmann
    Department of Epidemiology, German Institute of Human Nutrition, Potsdam Rehbrucke, Germany
    Int J Cancer 111:762-71. 2004

Detail Information

Publications247 found, 100 shown here

  1. ncbi Effect of exercise on total and intra-abdominal body fat in postmenopausal women: a randomized controlled trial
    Melinda L Irwin
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Conn, USA
    JAMA 289:323-30. 2003
    ..The increasing prevalence of obesity is a major public health concern. Physical activity may promote weight and body fat loss...
  2. ncbi Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial
    Jacques E Rossouw
    Division of Women s Health Initiative, National Heart, Lung, and Blood Institute, 6705 Rockledge Dr, One Rockledge Ctr, Suite 300, Bethesda, MD 20817
    JAMA 288:321-33. 2002
    ..Despite decades of accumulated observational evidence, the balance of risks and benefits for hormone use in healthy postmenopausal women remains uncertain...
  3. ncbi Pooled analysis of prospective cohort studies on height, weight, and breast cancer risk
    P A van den Brandt
    Department of Epidemiology, Maastricht University, The Netherlands
    Am J Epidemiol 152:514-27. 2000
    ..The association between BMI and breast cancer varies by menopausal status. Weight control may reduce the risk among postmenopausal women...
  4. pmc Insulin, insulin-like growth factor-I, and risk of breast cancer in postmenopausal women
    Marc J Gunter
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, New York, NY 10461, USA
    J Natl Cancer Inst 101:48-60. 2009
    ..However, no prospective studies have directly assessed associations between circulating levels of insulin and/or insulin-like growth factor (IGF)-I, a related hormone, and the risk of breast cancer independent of estrogen level...
  5. pmc A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer
    David J Hunter
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 39:870-4. 2007
    ..Our summary results from the GWAS are available online in a form that should speed the identification of additional risk loci...
  6. ncbi Estrogen plus progestin and colorectal cancer in postmenopausal women
    Rowan T Chlebowski
    Department of Medicine, Harbor UCLA Research and Education Institute, Torrance, Calif 90502, USA
    N Engl J Med 350:991-1004. 2004
    ..We analyzed features of the colorectal cancers that developed and their relation to the characteristics of the participants...
  7. ncbi Obesity, body size, and risk of postmenopausal breast cancer: the Women's Health Initiative (United States)
    Libby M Morimoto
    Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Cancer Causes Control 13:741-51. 2002
    ....
  8. ncbi Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial
    Garnet L Anderson
    Fred Hutchinson Cancer Research Center, Seattle, Wash 98109 1024, USA
    JAMA 291:1701-12. 2004
    ..Despite decades of use and considerable research, the role of estrogen alone in preventing chronic diseases in postmenopausal women remains uncertain...
  9. ncbi OPG and sRANKL serum concentrations in osteopenic, postmenopausal women after 2-year genistein administration
    Herbert Marini
    Department of Biochemical, Physiological and Nutritional Sciences, Section of Physiology and Human Nutrition, A O U Policlinico G Martino, Messina, Italy
    J Bone Miner Res 23:715-20. 2008
    ..Genistein, an isoflavone representing 1-5% of total phytoestrogen content in soybean products, may positively regulate cellular bone metabolism, but its mechanism of action on bone is not yet fully understood...
  10. ncbi Body size and breast cancer risk: findings from the European Prospective Investigation into Cancer And Nutrition (EPIC)
    Petra H Lahmann
    Department of Epidemiology, German Institute of Human Nutrition, Potsdam Rehbrucke, Germany
    Int J Cancer 111:762-71. 2004
    ..Among premenopausal women, weight and BMI showed nonsignificant inverse associations with breast cancer...
  11. ncbi Body mass index, serum sex hormones, and breast cancer risk in postmenopausal women
    T J Key
    Cancer Research U K Epidemiology Unit, University of Oxford, Gibson Bldg, Radcliffe Infirmary, Oxford OX2 6HE, UK
    J Natl Cancer Inst 95:1218-26. 2003
    ..Obesity is associated with increased breast cancer risk among postmenopausal women. We examined whether this association could be explained by the relationship of body mass index (BMI) with serum sex hormone concentrations...
  12. ncbi Genetic variation at the CYP19A1 locus predicts circulating estrogen levels but not breast cancer risk in postmenopausal women
    Christopher A Haiman
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA
    Cancer Res 67:1893-7. 2007
    ..Thus, although genetic variation in CYP19A1 produces measurable differences in estrogen levels among postmenopausal women, the magnitude of the change was insufficient to contribute detectably to breast cancer...
  13. ncbi Serum 25-hydroxyvitamin D and risk of post-menopausal breast cancer--results of a large case-control study
    Sascha Abbas
    Division of Cancer Epidemiology, German Cancer Research Center, 69120 Heidelberg, Germany
    Carcinogenesis 29:93-9. 2008
    ....
  14. ncbi Outcomes ascertainment and adjudication methods in the Women's Health Initiative
    J David Curb
    Department of Geriatric Medicine, University of Hawaii, Honolulu, HI 96813, USA
    Ann Epidemiol 13:S122-8. 2003
  15. ncbi Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/progestin Replacement Study (HERS) Research Group
    S Hulley
    University of California, San Francisco 94143, USA
    JAMA 280:605-13. 1998
    ..However, given the favorable pattern of CHD events after several years of therapy, it could be appropriate for women already receiving this treatment to continue...
  16. doi Insulin, insulin-like growth factor-I, endogenous estradiol, and risk of colorectal cancer in postmenopausal women
    Marc J Gunter
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 68:329-37. 2008
    ....
  17. ncbi A menopause-specific quality of life questionnaire: development and psychometric properties
    J R Hilditch
    Department of Family and Community Medicine, Sunnybrook Health Science Centre, University of Toronto, North York, Ontario, Canada
    Maturitas 24:161-75. 1996
    ....
  18. pmc Identification of common variants in the SHBG gene affecting sex hormone-binding globulin levels and breast cancer risk in postmenopausal women
    Deborah J Thompson
    Cambridge University, Strangeways Research Laboratories, Worts Causeway, Cambridge CB1 8RN, United Kingdom
    Cancer Epidemiol Biomarkers Prev 17:3490-8. 2008
    ..Three polymorphisms within the SHBG gene have been reported to affect SHBG levels, but there has been no systematic attempt to identify other such variants...
  19. ncbi Roles of androgens in the development, growth, and carcinogenesis of the mammary gland
    Dezhong J Liao
    Department of Oncology, Lombardi Cancer Center, Georgetown University Medical Center Research Building, W416, 3970 Reservoir Road NW, Washington, DC 20007, USA
    J Steroid Biochem Mol Biol 80:175-89. 2002
    ....
  20. pmc Postmenopausal hypertension
    Licy L Yanes
    Women s Health Research Center, University of Mississippi Medical Center, Jackson, Mississippi, USA
    Am J Hypertens 24:740-9. 2011
    ....
  21. pmc Effect of hormone therapy on lean body mass, falls, and fractures: 6-year results from the Women's Health Initiative hormone trials
    Jennifer W Bea
    Arizona Cancer Center, Tucson, AZ 85724 5024, USA
    Menopause 18:44-52. 2011
    ....
  22. pmc Greater endogenous estrogen exposure is associated with longer telomeres in postmenopausal women at risk for cognitive decline
    Jue Lin
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94118, USA
    Brain Res 1379:224-31. 2011
    ..The results suggest that the endogenous estrogens may be associated with deceleration of cellular aging. This is the first study to examine associations between endogenous estrogens, telomere length and telomerase activity...
  23. doi Serum adiponectin, bone mineral density and bone turnover markers in post-menopausal women with newly diagnosed Type 2 diabetes: a 12-month follow-up
    T Miazgowski
    Department of Hypertension and Internal Medicine, Pomeranian Medical University, Szczecin, Poland
    Diabet Med 29:62-9. 2012
    ....
  24. doi Interaction between menopausal status and obesity in affecting breast cancer risk
    David P Rose
    Department of Surgery, Mary Babb Randolph Cancer Center, West Virginia University Robert C Byrd Health Sciences Center, Morgantown, WV 26506, USA
    Maturitas 66:33-8. 2010
    ....
  25. pmc Diabetes, metformin, and breast cancer in postmenopausal women
    Rowan T Chlebowski
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
    J Clin Oncol 30:2844-52. 2012
    ..Therefore, we assessed associations among diabetes, metformin use, and breast cancer in postmenopausal women participating in Women's Health Initiative clinical trials...
  26. doi Mammographic density, response to hormones, and breast cancer risk
    Norman F Boyd
    DSC, Ontario Cancer Institute, 610 University Ave, Room 10 415, Toronto, Ontario, Canada
    J Clin Oncol 29:2985-92. 2011
    ..We have examined the magnitude of the association of hormone exposure with PMD according to subsequent breast cancer risk...
  27. pmc The soy isoflavones for reducing bone loss (SIRBL) study: a 3-y randomized controlled trial in postmenopausal women
    D Lee Alekel
    Nutrition and Wellness Research Center, Department of Food Science and Human Nutrition, Iowa State University, Ames, IA 50010 8281, USA
    Am J Clin Nutr 91:218-30. 2010
    ..Our previous study indicated that soy protein with isoflavones lessened lumbar spine bone loss in midlife women...
  28. ncbi Obesity and fractures in postmenopausal women
    Melissa Orlandin Premaor
    Department of Medicine, University of Cambridge, Cambridge, United Kingdom
    J Bone Miner Res 25:292-7. 2010
    ....
  29. ncbi Aromatase inhibitors in the treatment of severe endometriosis
    Noha A Mousa
    Institute of Medical Science, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    Obstet Gynecol 109:1421-3. 2007
    ..Endometriosis-associated chronic pelvic pain unresponsive to surgical menopause is a difficult clinical problem...
  30. pmc Relationship between caffeine intake and plasma sex hormone concentrations in premenopausal and postmenopausal women
    Joanne Kotsopoulos
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer 115:2765-74. 2009
    ..Caffeine intake may decrease risk of breast and ovarian cancer, although the data are not entirely consistent. Whether or not caffeine affects cancer risk by altering sex hormone levels is currently unknown...
  31. doi Metabolic implications of menopause
    Hanah N Polotsky
    Weill Cornell Medical Center and Memorial Sloan Kettering Cancer Center, New York 10065, USA
    Semin Reprod Med 28:426-34. 2010
    ..This review focuses on metabolic changes associated with menopausal transition, specifically alterations in weight, waist circumference, body fat distribution, energy expenditure, and circulating biomarkers including adipokines...
  32. pmc Comprehensive analysis of hormone and genetic variation in 36 genes related to steroid hormone metabolism in pre- and postmenopausal women from the breast and prostate cancer cohort consortium (BPC3)
    L Beckmann
    Division of Cancer Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany
    J Clin Endocrinol Metab 96:E360-7. 2011
    ..Sex steroids play a central role in breast cancer development...
  33. ncbi Human cultured skin fibroblasts express estrogen receptor alpha and beta
    Jozef Haczynski
    Eli Lilly, Medical Department Poland, 01 698 Warszawa, Poland
    Int J Mol Med 10:149-53. 2002
    ..The dominant expression of ER-beta in cultured female skin fibroblasts suggests that ER-beta may play a dominant role in collaboration with ER-alpha in the regulation of estrogen action in skin...
  34. pmc Relation between obesity and bone mineral density and vertebral fractures in Korean postmenopausal women
    Kyong Chol Kim
    Department of Family Medicine, MizMedi Hospital, Seoul, Korea
    Yonsei Med J 51:857-63. 2010
    ..Using a cross sectional study design, we evaluated the associations between obesity or metabolic syndrome and bone mineral density (BMD) or vertebral fracture...
  35. doi Double-blind, randomized placebo controlled trial of fulvestrant compared with exemestane after prior nonsteroidal aromatase inhibitor therapy in postmenopausal women with hormone receptor-positive, advanced breast cancer: results from EFECT
    Stephen Chia
    Division of Medical Oncology, British Columbia Cancer Agency, University of British Columbia, 600 West 10 Avenue, Vancouver, BC, Canada
    J Clin Oncol 26:1664-70. 2008
    ..Because many patients subsequently experience progression or relapse, it is important to identify agents with efficacy after AI failure...
  36. doi Body mass index and physical activity in relation to the incidence of hip fracture in postmenopausal women
    Miranda E G Armstrong
    Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom
    J Bone Miner Res 26:1330-8. 2011
    ..68 (95% CI 0.62-0.75), with similar results for strenuous exercise. In this large cohort of postmenopausal women, BMI and physical activity had independent effects on hip fracture risk...
  37. pmc Deciphering normal blood gene expression variation--The NOWAC postgenome study
    Vanessa Dumeaux
    Institute of Community Medicine, University of Tromsø, Tromsø, Norway
    PLoS Genet 6:e1000873. 2010
    ....
  38. ncbi Optimizing endocrine therapy for breast cancer
    Eric P Winer
    J Clin Oncol 23:1609-10. 2005
  39. doi Conformity to traditional Mediterranean diet and breast cancer risk in the Greek EPIC (European Prospective Investigation into Cancer and Nutrition) cohort
    Antonia Trichopoulou
    WHO Collaborating Center for Food and Nutrition Policies, Department of Hygiene, Epidemiology and Medical Statistics, Athens, Greece
    Am J Clin Nutr 92:620-5. 2010
    ..No study, however, has evaluated the association of the traditional Mediterranean diet with breast cancer in a Mediterranean country...
  40. ncbi Risk of different histological types of postmenopausal breast cancer by type and regimen of menopausal hormone therapy
    Dieter Flesch-Janys
    Department of Medical Biometry and Epidemiology, Center for Experimental Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Int J Cancer 123:933-41. 2008
    ..These data suggest that the risks associated with menopausal HT differ by type and regimen of HT and histological type of breast cancer and may vary by progestagenic component, depending on the effective dose...
  41. doi Prospective study to assess short-term intra-articular and tenosynovial changes in the aromatase inhibitor-associated arthralgia syndrome
    Leilani Morales
    Department of Obstetrics and Gynecology, Division of Gynecological Oncology, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    J Clin Oncol 26:3147-52. 2008
    ..To date, its exact mechanism remains unclear. The purpose of this study was to investigate the changes in clinical rheumatologic features and magnetic resonance imaging (MRI) of hands and wrists in AI and tamoxifen users...
  42. ncbi Meta-analysis of walking for preservation of bone mineral density in postmenopausal women
    Marrissa Martyn-St James
    Carnegie Faculty of Sport and Education, Leeds Metropolitan University, Room 202, Fairfax Hall, Headingley Campus, Leeds LS6 3QT, UK
    Bone 43:521-31. 2008
    ..Other forms of exercise that provide greater targeted skeletal loading may be required to preserve bone mineral density in this population...
  43. pmc Alberta physical activity and breast cancer prevention trial: sex hormone changes in a year-long exercise intervention among postmenopausal women
    Christine M Friedenreich
    Alberta Health Services, Calgary, Alberta, Canada
    J Clin Oncol 28:1458-66. 2010
    ....
  44. ncbi Successful treatment of an aggressive recurrent post-menopausal endometriosis with an aromatase inhibitor
    H M Fatemi
    Centre of Reproductive Medicine, AZ VUB, University Hospital, Dutch speaking Free University of Brussels, Laarbeeklaan 101, 1090 Brussels, Belgium
    Reprod Biomed Online 11:455-7. 2005
    ..Medical management of recurrent post-menopausal endometriosis with aromatase inhibitors seems to be an effective alternative treatment to surgery...
  45. ncbi The underlying basis for obesity: relationship to cancer
    George A Bray
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    J Nutr 132:3451S-3455S. 2002
    ..Efforts to control obesity through preventive strategies and treatment can be expected to have a benefit in reducing the risk of cancer...
  46. ncbi High-fiber rye bread and insulin secretion and sensitivity in healthy postmenopausal women
    Katri S Juntunen
    Department of Clinical Nutrition, University of Kuopio, Kuopio, Finland
    Am J Clin Nutr 77:385-91. 2003
    ..Fiber and whole-cereal intakes may protect against hyperinsulinemia and the risk of type 2 diabetes...
  47. doi Ratio of 17HSD1 to 17HSD2 protein expression predicts the outcome of tamoxifen treatment in postmenopausal breast cancer patients
    Agneta Jansson
    Department of Clinical and Experimental Medicine, Division of Oncology, Linkoping University, Linkoping, Sweden
    Clin Cancer Res 15:3610-6. 2009
    ..The aim of this study was to investigate the prognostic and tamoxifen predictive values of 17HSD1 and 17HSD2 expression...
  48. ncbi Dietary intake of phytoestrogens is associated with a favorable metabolic cardiovascular risk profile in postmenopausal U.S.women: the Framingham study
    Miriam J J de Kleijn
    Julius Center for General Practice and Patient Oriented Research, University Medical Center, Utrecht, The Netherlands
    J Nutr 132:276-82. 2002
    ..55 points (95% CI, -0.82 to -0.28). In conclusion, high intake of phytoestrogens in postmenopausal women appears to be associated with a favorable metabolic cardiovascular risk profile...
  49. ncbi Prospective cohort study of soy food consumption and risk of bone fracture among postmenopausal women
    Xianglan Zhang
    Department of Medicine, Center for Health Services Research, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tenn 37232 8300, USA
    Arch Intern Med 165:1890-5. 2005
    ..Soy consumption has been shown to modulate bone turnover and increase bone mineral density in postmenopausal women. To our knowledge, no published studies have directly examined the association between soy consumption and risk of fracture...
  50. ncbi Effects of isoflavone and exercise on BMD and fat mass in postmenopausal Japanese women: a 1-year randomized placebo-controlled trial
    Jian Wu
    Division of Applied Food Research, National Institute of Health and Nutrition, Tokyo, Japan
    J Bone Miner Res 21:780-9. 2006
    ..The combined intervention of isoflavone intake and walking exercise over 1 year in postmenopausal Japanese women exhibited a trend for a greater effect on prevention of bone loss at the total hip and Ward's triangle regions...
  51. doi Metabolic syndrome after menopause and the role of hormones
    Rogerio A Lobo
    Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, NY 10032, United States
    Maturitas 60:10-8. 2008
    ..The purpose of this review is to focus on the importance of metabolic syndrome (MBS) and its increased prevalence in postmenopausal (PM) women. Also the role of hormonal therapy in PM women with MBS will be discussed...
  52. doi Physical activity and postmenopausal breast cancer: proposed biologic mechanisms and areas for future research
    Heather K Neilson
    Division of Population Health, Alberta Cancer Board, 1331 29 Street NW, Calgary, Alberta, Canada T2N 4N2
    Cancer Epidemiol Biomarkers Prev 18:11-27. 2009
    ..Future etiologic studies should consider interactions among biomarkers, whereas exercise trials should explore exercise effects independently of weight loss, different exercise prescriptions, and effects on central adiposity...
  53. ncbi A clinical trial of estrogen-replacement therapy after ischemic stroke
    C M Viscoli
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Conn. 06520-8056, USA
    N Engl J Med 345:1243-9. 2001
    ..CONCLUSIONS: Estradiol does not reduce mortality orthe recurrence of stroke in postmenopausal women with cerebrovascular disease. This therapy should not be prescribed for the secondary prevention of cerebrovascular disease...
  54. doi Body weight and incidence of breast cancer defined by estrogen and progesterone receptor status--a meta-analysis
    Reiko Suzuki
    Institute of Environmental Medicine, Division of Nutritional Epidemiology, Karolinska Institutet, Stockholm, Sweden
    Int J Cancer 124:698-712. 2009
    ..The relation between body weight and breast cancer risk is critically dependent on the tumor's ER/PR status and the woman's menopausal status. Body weight control is the effective strategy for preventing ER+PR+ tumors after menopause...
  55. ncbi Carbohydrate intake, glycemic index, glycemic load, and risk of postmenopausal breast cancer in a prospective study of French women
    Martin Lajous
    INSERM, ERI 20, EA 4045, and Institut Gustave Roussy, Villejuif, France
    Am J Clin Nutr 87:1384-91. 2008
    ..Insulin response to carbohydrate intake is increased in insulin-resistant states such as obesity...
  56. ncbi Obesity, estrone, and coronary artery disease in postmenopausal women
    T C B F Silva
    Heart Institute InCor, University of Sao Paulo Medical School, 05468 000 São Paulo, Brazil
    Maturitas 59:242-8. 2008
    ..In this prospective study we analyzed the association of body mass index (BMI) and blood levels of estrone in postmenopausal women with known CAD or with a high risk factor score for CAD...
  57. ncbi Calcium, vitamin D, milk consumption, and hip fractures: a prospective study among postmenopausal women
    Diane Feskanich
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Clin Nutr 77:504-11. 2003
    ..Fewer studies have focused on vitamin D in preventing postmenopausal osteoporosis or fractures...
  58. pmc Obstetric history and mammographic density: a population-based cross-sectional study in Spain (DDM-Spain)
    Virginia Lope
    Cancer Epidemiology Unit, National Center of Epidemiology, Instituto de Salud Carlos III, Monforte de Lemos 5, 28029 Madrid, Spain
    Breast Cancer Res Treat 132:1137-46. 2012
    ..These results suggest the influence of hormones and growth factors over the proliferative activity of the mammary gland...
  59. doi Postmenopausal serum sex steroids and risk of hormone receptor-positive and -negative breast cancer: a nested case-control study
    Rebecca E James
    Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Cancer Prev Res (Phila) 4:1626-35. 2011
    ....
  60. pmc Age- and gender-related differences in the geometric properties and biomechanical significance of intracortical porosity in the distal radius and tibia
    Andrew J Burghardt
    Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, USA
    J Bone Miner Res 25:983-93. 2010
    ..The biomechanical significance of these structural differences increases with age for men and women and provides discriminatory information for menopause-related bone quality effects...
  61. ncbi Understanding the pathophysiology of vasomotor symptoms (hot flushes and night sweats) that occur in perimenopause, menopause, and postmenopause life stages
    D C Deecher
    Women s Health Research, Wyeth Pharmaceuticals, Collegeville, PA 19426, USA
    Arch Womens Ment Health 10:247-57. 2007
    ..This review considers the processes and pathways involved in normal temperature regulation and the impact of fluctuating and declining hormones that result in VMS during the menopausal transition...
  62. pmc Comparison of mucin levels at the ocular surface of postmenopausal women with and without a history of dry eye
    Ilene K Gipson
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Cornea 30:1346-52. 2011
    ....
  63. pmc Expression of ER-{alpha}36, a novel variant of estrogen receptor {alpha}, and resistance to tamoxifen treatment in breast cancer
    Liang Shi
    Breast Center, Beijing Cancer Hospital and Institute, Peking University School of Oncology, Beijing, 100036, PR China
    J Clin Oncol 27:3423-9. 2009
    ..47; 95% CI, 1.81 to 16.51; P =. 003; DSS: HR = 13.97; 95% CI, 1.58 to 123.53; P = .018). CONCLUSION Women with ER-alpha66-positive tumors that also express high levels of ER-alpha36 are less likely to benefit from tamoxifen treatment...
  64. pmc Individual trabecula segmentation (ITS)-based morphological analyses and microfinite element analysis of HR-pQCT images discriminate postmenopausal fragility fractures independent of DXA measurements
    X Sherry Liu
    Division of Endocrinology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Bone Miner Res 27:263-72. 2012
    ..We conclude that HR-pQCT-based ITS and µFEA measurements increase our understanding of the microstructural pathogenesis of fragility fracture in postmenopausal women...
  65. ncbi Adrenal androgens and intracrinology
    Fernand Labrie
    Oncology and Molecular Endocrinology Research Center, Laval University Hospital Research Center, Quebec City, Canada
    Semin Reprod Med 22:299-309. 2004
    ..The benefits of DHEA include increased bone mineral density, muscle mass, well-being, and libido, as well as beneficial effects against skin atrophy, type 2 diabetes, and obesity...
  66. ncbi Vasomotor hot flushes and 24-hour ambulatory blood pressure in normotensive women: A placebo-controlled trial on post-menopausal hormone therapy
    Pauliina Tuomikoski
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland
    Ann Med 42:334-43. 2010
    ..Thus, we compared in a clinical trial the effect of HT on ambulatory BP in normotensive, recently post-menopausal women with or without severe hot flushes...
  67. doi The relationship of mammographic density and age: implications for breast cancer screening
    Cristina M Checka
    Department of Surgery, New York University Langone Medical Center, 160 E 34th St, New York, NY 10016, USA
    AJR Am J Roentgenol 198:W292-5. 2012
    ..However, the actual proportion of older women with dense breasts is unknown. The purpose of this study was to examine the relationship between age and breast density, particularly focusing on postmenopausal women...
  68. pmc Postmenopausal levels of endogenous sex hormones and risk of colorectal cancer
    Tess V Clendenen
    Division of Epidemiology, Department of Environmental Medicine, New York University School of Medicine, 650 First Avenue, 5th Floor, New York, NY 10016 3240, USA
    Cancer Epidemiol Biomarkers Prev 18:275-81. 2009
    ..Our results suggest that endogenous estrone is associated with increased risk of colorectal cancer in postmenopausal women...
  69. ncbi Recommendations for the management of postmenopausal vaginal atrophy
    D W Sturdee
    Department of Obstetrics and Gynaecology, Heart of England NHS Foundation Trust, Solihull Hospital, UK
    Climacteric 13:509-22. 2010
    ....
  70. doi Effects of soya isoflavones and exercise on body composition and clinical risk factors of cardiovascular diseases in overweight postmenopausal women: a 6-month double-blind controlled trial
    Stephane Choquette
    Faculty of Physical Education and Sports, University of Sherbrooke, Sherbrooke, QC, Canada J1K 2R1
    Br J Nutr 105:1199-209. 2011
    ..No synergistic effects were observed between exercise and isoflavones. However, isoflavones could have a beneficial effect on leg FM%...
  71. pmc Attitudes of postmenopausal women toward interactive video dance for exercise
    Marco Inzitari
    Department of Medicine, Division of Geriatric Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Womens Health (Larchmt) 18:1239-43. 2009
    ..We explored perceived advantages and disadvantages of video dance as a personal exercise option in postmenopausal women...
  72. doi Urban tropospheric ozone increases the prevalence of vitamin D deficiency among Belgian postmenopausal women with outdoor activities during summer
    Daniel Henri Manicourt
    Department of Rheumatology, St Luc University Hospital, UCL 5390, 1200 Brussels, Belgium
    J Clin Endocrinol Metab 93:3893-9. 2008
    ..By absorbing sunlight UVB and thereby reducing cutaneous vitamin D photosynthesis, ozone, a common urban pollutant, could cause hypovitaminosis D...
  73. ncbi Dietary glycemic index, glycemic load, and the risk of breast cancer in an Italian prospective cohort study
    Sabina Sieri
    Nutritional Epidemiology Unit, National Cancer Institute, Milan, Italy
    Am J Clin Nutr 86:1160-6. 2007
    ..Interest in the roles of glycemic index (GI) and glycemic load (GL) in breast cancer etiology has been stimulated by indications that disease risk is linked to insulinemia, sex hormone bioavailability, and insulin-like growth factor 1...
  74. ncbi Effects of different doses of physical activity on cardiorespiratory fitness among sedentary, overweight or obese postmenopausal women with elevated blood pressure: a randomized controlled trial
    Timothy S Church
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge 70808 4124, USA
    JAMA 297:2081-91. 2007
    ..However, a poor understanding of the physical activity-fitness dose response relation remains...
  75. pmc Centrally located body fat is related to appetitive hormones in healthy postmenopausal women
    Laura M Ritland
    Human Metabolic Unit, Department of Food Science and Human Nutrition, Iowa State University, 1115 Human Nutritional Sciences Building, Ames, Iowa 50011, USA
    Eur J Endocrinol 158:889-97. 2008
    ..This study examined whether centrally located fat and/or overall adiposity were related to these appetitive hormones in healthy postmenopausal women...
  76. pmc Changes in weight, waist circumference and compensatory responses with different doses of exercise among sedentary, overweight postmenopausal women
    Timothy S Church
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA
    PLoS ONE 4:e4515. 2009
    ..The goal of this analysis was to examine actual weight loss compared to predicted weight loss (compensation) across different doses of exercise in a controlled trial of sedentary, overweight or obese postmenopausal women (n = 411)...
  77. pmc Vitamin K supplementation in postmenopausal women with osteopenia (ECKO trial): a randomized controlled trial
    Angela M Cheung
    Department of Medicine, Division of General Internal Medicine, University of Toronto, Toronto, Ontario, Canada
    PLoS Med 5:e196. 2008
    ..This study was conducted to determine whether daily high-dose vitamin K1 supplementation safely reduces bone loss, bone turnover, and fractures...
  78. doi Plasma hormones, muscle mass and strength in resistance-trained postmenopausal women
    Fabio L Orsatti
    Center of Nutrition and Exercise Metabolism of Department of Public Health, Botucatu Medical School, Sao Paulo State University, Brazil
    Maturitas 59:394-404. 2008
    ..To associate changes of body composition, muscle strength (MS) and plasma hormones (PH) in resistance-training protocol in sedentary postmenopausal women (PMW)...
  79. pmc Calcium plus vitamin D supplementation and the risk of breast cancer
    Rowan T Chlebowski
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
    J Natl Cancer Inst 100:1581-91. 2008
    ..Although some observational studies have associated higher calcium intake and especially higher vitamin D intake and 25-hydroxyvitamin D levels with lower breast cancer risk, no randomized trial has evaluated these relationships...
  80. pmc Vitamin K2 supplementation improves hip bone geometry and bone strength indices in postmenopausal women
    M H J Knapen
    CARIM, University of Maastricht, Maastricht, The Netherlands
    Osteoporos Int 18:963-72. 2007
    ..Results showed that K(2) improved BMC and femoral neck width, but not DXA-BMD. Hence high vitamin K(2) intake may contribute to preventing postmenopausal bone loss...
  81. pmc Serum 25-hydroxyvitamin D concentrations and postmenopausal breast cancer risk: a nested case control study in the Cancer Prevention Study-II Nutrition Cohort
    Marjorie L McCullough
    Epidemiology Research, American Cancer Society, 240 Williams Street, Atlanta, GA 30303 1002, USA
    Breast Cancer Res 11:R64. 2009
    ..Vitamin D has been hypothesized to prevent breast cancer through genomic and non-genomic actions in cell-cycle regulation...
  82. ncbi Total body aromatization in postmenopausal breast cancer patients is strongly correlated to plasma leptin levels
    Jurgen Geisler
    Department of Oncology, Haukeland University Hospital, Bergen, Norway
    J Steroid Biochem Mol Biol 104:27-34. 2007
    ..These findings suggest that leptin may influence on aromatase activity in vivo, providing a possible link between body weight and plasma estrogen levels as well as breast cancer risk...
  83. doi Correlation between the rate of weight loss and changes in body composition in obese postmenopausal women after 5 weeks: a pilot study
    Hélène Arguin
    Faculty of Physical Education and Sports, University of Sherbrooke, Sherbrooke, QC, Canada
    Appl Physiol Nutr Metab 33:347-55. 2008
    ..Current guidelines, which recommend RWL up to 0.91 kg.week(-1), might not be optimal to prevent decreases in LBM in postmenopausal women when no exercise is added...
  84. pmc Adiposity changes after a 1-year aerobic exercise intervention among postmenopausal women: a randomized controlled trial
    C M Friedenreich
    Department of Population Health Research, Alberta Health Services, Calgary, Alberta, Canada
    Int J Obes (Lond) 35:427-35. 2011
    ..We examined the effects of an aerobic exercise intervention on adiposity outcomes that may be involved in the association between physical activity and breast cancer risk...
  85. ncbi Effects of continuing or stopping alendronate after 5 years of treatment: the Fracture Intervention Trial Long-term Extension (FLEX): a randomized trial
    Dennis M Black
    San Francisco Coordinating Center, Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94107, USA
    JAMA 296:2927-38. 2006
    ..The optimal duration of treatment of women with postmenopausal osteoporosis is uncertain...
  86. ncbi Usual physical activity and endogenous sex hormones in postmenopausal women: the European prospective investigation into cancer-norfolk population study
    Mei Fen Chan
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom
    Cancer Epidemiol Biomarkers Prev 16:900-5. 2007
    ..However, the relationship between usual daily physical activity and endogenous hormones in postmenopausal women in the general population is still uncertain...
  87. ncbi Correlation of body mass index and leptin with tumor size and stage of disease in hormone-dependent postmenopausal breast cancer: preliminary results and therapeutic implications
    Antonio Maccio
    Department of Obstetrics and Gynecology, Sirai Hospital, 09013 Carbonia, Italy
    J Mol Med (Berl) 88:677-86. 2010
    ..Further studies are warranted to clarify the role of leptin and interleukin-6 in breast carcinogenesis and identify new therapeutic options, beyond the use of aromatase inhibitors, acting selectively on adipokine-driven pathways...
  88. ncbi Prospective study of dietary protein intake and risk of hip fracture in postmenopausal women
    R G Munger
    Department of Nutrition and Food Sciences, Utah State University, Logan 84322 8700, USA
    Am J Clin Nutr 69:147-52. 1999
    ..Protein is an important structural component of bone and protein supplementation improves the medical outcome of hip fracture patients, but it is unknown whether protein intake can reduce the incidence risk of hip fracture...
  89. pmc Influence of menopause on high density lipoprotein-cholesterol and lipids
    C J Kim
    Department of Internal Medicine, Chung Ang University Medical Center, Seoul, Korea
    J Korean Med Sci 15:380-6. 2000
    ..051). Total cholesterol levels showed stepwise elevation from premenopause to postmenopause. Perimenopausal women had lower Lp(a) levels than postmenopausal women (p<0...
  90. ncbi Changes in plasma leptin and insulin action with resistive training in postmenopausal women
    A S Ryan
    Department of Medicine, Division of Gerontology at the University of Maryland School of Medicine, and the Geriatric Research, Education and Clinical Center GRECC, Baltimore VA Medical Center, Baltimore, MD 21201, USA
    Int J Obes Relat Metab Disord 24:27-32. 2000
    ....
  91. ncbi Relation of BMI and physical activity to sex hormones in postmenopausal women
    Anne McTiernan
    Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Cancer Prevention Research Program, Seattle, WA 98109, USA
    Obesity (Silver Spring) 14:1662-77. 2006
    ..However, the determinants of these hormone concentrations are not established. The purpose of this study was to examine correlates of endogenous sex hormones...
  92. ncbi An algorithm including results of gray-scale and power Doppler ultrasound examination to predict endometrial malignancy in women with postmenopausal bleeding
    E Epstein
    Department of Obstetrics and Gynecology, Malmo University Hospital, Lund University, Sweden
    Ultrasound Obstet Gynecol 20:370-6. 2002
    ..To determine if power Doppler ultrasound examination of the endometrium can contribute to a correct diagnosis of endometrial malignancy in women with postmenopausal bleeding and endometrium > or = 5 mm...
  93. ncbi Association of CYP17, CYP19, CYP1B1, and COMT polymorphisms with serum and urinary sex hormone concentrations in postmenopausal women
    Shelley S Tworoger
    The Fred Hutchinson Cancer Research Center, Cancer Prevention Research Program, Seattle, Washington, USA
    Cancer Epidemiol Biomarkers Prev 13:94-101. 2004
    ..This study provides further evidence that genetic variation may appreciably alter sex hormone concentrations in postmenopausal women not taking hormone therapy...
  94. ncbi Estrogens reduce and withdrawal of estrogens increase risk of microsatellite instability-positive colon cancer
    M L Slattery
    Health Research Center, Department of Family and Preventive Medicine, University of Utah, Salt Lake City 84108, USA
    Cancer Res 61:126-30. 2001
    ..HRT in these older women may, again, reduce the risk of unstable tumors. A model for the way in which estrogens (endogenous, exogenous, and obesity-associated) modify the risk of MSI+ tumors is proposed...
  95. ncbi Adult weight change and risk of postmenopausal breast cancer
    A Heather Eliassen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02115, USA
    JAMA 296:193-201. 2006
    ..Endogenous hormones are a primary cause of breast cancer. Adiposity affects circulating hormones, particularly in postmenopausal women, and may be a modifiable risk factor for breast cancer...
  96. ncbi Body mass index, circulating levels of sex-steroid hormones, IGF-I and IGF-binding protein-3: a cross-sectional study in healthy women
    A Lukanova
    Hormones and Cancer Group, International Agency for Research on Cancer, Lyon, France
    Eur J Endocrinol 150:161-71. 2004
    ....
  97. doi Association of total calcium and dietary protein intakes with fracture risk in postmenopausal women: the 1999-2002 National Health and Nutrition Examination Survey (NHANES)
    Yuna Zhong
    National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Nutrition 25:647-54. 2009
    ..We examined the associations of total calcium intake (TCI) and dietary protein intake (DPI) with risk of fracture...
  98. pmc Reproducibility of plasma and urine biomarkers among premenopausal and postmenopausal women from the Nurses' Health Studies
    Joanne Kotsopoulos
    Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 19:938-46. 2010
    ..Temporal variability of biomarkers should be evaluated before their use in epidemiologic studies...
  99. ncbi Prevalence of vitamin D inadequacy in European postmenopausal women
    O Bruyere
    WHO Collaborating Center for Public Health Aspect of Osteoarticular Disorders and Department of Public Health, Epidemiology and Health Economics, University of Liege, Belgium
    Curr Med Res Opin 23:1939-44. 2007
    ..There are no clear international agreements on what constitutes a level of vitamin D inadequacy, but recent publications suggest that the circulating level of vitamin D should be over 80 nmol/L or at least between 50 and 80 nmol/L...
  100. ncbi Effect of long-term estrogen deprivation on apoptotic responses of breast cancer cells to 17beta-estradiol
    R X Song
    Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville, USA
    J Natl Cancer Inst 93:1714-23. 2001
    ..1 nM estradiol by increasing apoptosis. CONCLUSION: Tumor regression induced by high-dose estrogen therapy in postmenopausal woman may result from estrogen activation of Fas-mediated apoptosis...

Research Grants89

  1. Restoration of Estradiol Effects on Learning by Cholinergic Enhancement
    Robert Gibbs; Fiscal Year: 2009
    ....
  2. Sex Hormones in Postmenopausal Women in the Diabetes Prevention Program
    Catherine Kim; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Although postmenopause is a universal experience of aging and is defined by permanent changes in ovarian function, we still do not understand how postmenopausal sex hormones affect diabetes risk...
  3. Novel Mechanistic Targets of Steroid Hormones in the Brain
    Meharvan Singh; Fiscal Year: 2009
    ....
  4. Novel Mechanistic Targets of Steroid Hormones in the Brain
    Meharvan Singh; Fiscal Year: 2007
    ....
  5. Viscoelastic deformation of bone matrix in postmenopause
    Do Gyoon Kim; Fiscal Year: 2009
    ..The outcomes of this project will contribute to the development of more effective therapies for treating osteoporosis associated with estrogen deficiency in postmenopausal patients. ..
  6. Viscoelastic deformation of bone matrix in postmenopause
    Do Gyoon Kim; Fiscal Year: 2010
    ..The outcomes of this project will contribute to the development of more effective therapies for treating osteoporosis associated with estrogen deficiency in postmenopausal patients. ..
  7. Prevention of Menopause-Related Ovarian Epithelial Cancer
    Elizabeth Smith; Fiscal Year: 2009
    ..The goal is to formulate rationale preventive strategies for ovarian cancer in post-menopausal women. ..
  8. Prevention of Menopause-Related Ovarian Epithelial Cancer
    Elizabeth R Smith; Fiscal Year: 2010
    ..The goal is to formulate rationale preventive strategies for ovarian cancer in post-menopausal women. ..
  9. ROLE OF SRC TYROSINE KINASE IN OSTEOCLAST FUNCTION
    Toshiyuki Yoneda; Fiscal Year: 1992
    ....
  10. MENOPAUSE AND MIDLIFE AGING EFFECTS ON SLEEP DISORDERS
    Terry Young; Fiscal Year: 2001
    ..The specific aims, will be addressed using standard definition of menopause and dyssomnias, with longitudinal multivariate models able to control for confounding factors and to investigate interactions. ..
  11. MENOPAUSE AND MIDLIFE AGING EFFECTS ON SLEEP DISORDERS
    Terry Young; Fiscal Year: 2000
    ..The specific aims, will be addressed using standard definition of menopause and dyssomnias, with longitudinal multivariate models able to control for confounding factors and to investigate interactions. ..
  12. MENOPAUSE AND MIDLIFE AGING EFFECTS ON SLEEP DISORDERS
    Terry Young; Fiscal Year: 1999
    ..The specific aims, will be addressed using standard definition of menopause and dyssomnias, with longitudinal multivariate models able to control for confounding factors and to investigate interactions. ..
  13. MENOPAUSE AND MIDLIFE AGING EFFECTS ON SLEEP DISORDERS
    Terry Young; Fiscal Year: 2005
    ....
  14. MENOPAUSE AND MIDLIFE AGING EFFECTS ON SLEEP DISORDERS
    Terry Young; Fiscal Year: 2004
    ....
  15. MENOPAUSE AND MIDLIFE AGING EFFECTS ON SLEEP DISORDERS
    Terry Young; Fiscal Year: 2003
    ....
  16. MENOPAUSE AND MIDLIFE AGING EFFECTS ON SLEEP DISORDERS
    Terry Young; Fiscal Year: 2002
    ....
  17. ROLE OF BIOACTIVE FSH IN REPRODUCTION
    Aaron Hsueh; Fiscal Year: 1990
    ..will also be studied during the preovulatory period, luteal- follicular transition, puberty onset, pregnancy, postmenopause and aging in human beings and other animals...
  18. MENOPAUSE AND MIDLIFE AGING EFFECTS ON SLEEP DISORDERS
    Terry Young; Fiscal Year: 2006
    ....
  19. Study of Women's Health Across the Nation V: Endocrinology/CLASS Laboratory
    Daniel McConnell; Fiscal Year: 2009
    ..new areas of endocrine importance, and extend the study of hormonal characteristics from the early to late postmenopause. We will challenge the traditional concept of the menopausal transition as simply a loss of ovarian estradiol ..
  20. Defining the Mechanisms of Menopause-Associated Sleep and Mood Disturbances
    Hadine Joffe; Fiscal Year: 2009
    ..Women are at increased risk for insomnia and depression during the perimenopause and early postmenopause. Hot flashes have been linked to menopause-associated insomnia and depression, but the biological basis of ..
  21. Defining the Mechanisms of Menopause-Associated Sleep and Mood Disturbances
    Hadine Joffe; Fiscal Year: 2010
    ..Women are at increased risk for insomnia and depression during the perimenopause and early postmenopause. Hot flashes have been linked to menopause-associated insomnia and depression, but the biological basis of ..
  22. EPIDEMIOLOGY OF HORMONES AND OSTEOPOROSIS
    Lewis Kuller; Fiscal Year: 1990
    ..We will test the hypothesis that both cortical and trabecular bone are primarily determined by dietary intake of calcium during periods of increasing and stable bone mass and the levels of endogenous estrogens in the blood...
  23. WOMENS HEALTH ACROSS THE NATION--ENDOCRINE LAB
    Daniel McConnell; Fiscal Year: 2002
    ..ovarian markers which have the potential to allow us to hormonally define the menopausal transition and the postmenopause with greater precision (inhibin A and B, estrone)...
  24. WOMENS HEALTH ACROSS THE NATION--ENDOCRINE LAB
    A Midgley; Fiscal Year: 1999
    ..ovarian markers which have the potential to allow us to hormonally define the menopausal transition and the postmenopause with greater precision (inhibin A and B, estrone)...
  25. TAMOXIFEN AND RETINOIC ACID EFFECT ON THE UTERUS
    Kenneth Nephew; Fiscal Year: 1999
    ..An understanding of the mechanism of action of tamoxifen and 4-HPR on uterine epithelia is of interest and of the utmost relevance to the evaluation of tamoxifen as a chemopreventive regimen for breast cancer. ..
  26. TAMOXIFEN AND RETINOIC ACID EFFECT ON THE UTERUS
    Kenneth Nephew; Fiscal Year: 2000
    ..An understanding of the mechanism of action of tamoxifen and 4-HPR on uterine epithelia is of interest and of the utmost relevance to the evaluation of tamoxifen as a chemopreventive regimen for breast cancer. ..
  27. WOMENS HEALTH ACROSS THE NATION--ENDOCRINE LAB
    A Midgley; Fiscal Year: 2000
    ..ovarian markers which have the potential to allow us to hormonally define the menopausal transition and the postmenopause with greater precision (inhibin A and B, estrone)...
  28. WOMENS HEALTH ACROSS THE NATION--ENDOCRINE LAB
    Daniel McConnell; Fiscal Year: 2001
    ..ovarian markers which have the potential to allow us to hormonally define the menopausal transition and the postmenopause with greater precision (inhibin A and B, estrone)...
  29. MELATONIN FOR AGE-RELATED SLEEP DISTURBANCE IN WOMEN
    Patricia Murphy; Fiscal Year: 2005
    ....
  30. MELATONIN FOR AGE-RELATED SLEEP DISTURBANCE IN WOMEN
    Patricia Murphy; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  31. Role of the Follicle-Depleted Ovary in the Pathogenesis of Chronic Diseases
    JAY KAPLAN; Fiscal Year: 2007
    ....
  32. Role of the Follicle-Depleted Ovary in the Pathogenesis of Chronic Diseases
    JAY KAPLAN; Fiscal Year: 2006
    ....
  33. Role of the Follicle-Depleted Ovary in the Pathogenesis of Chronic Diseases
    JAY KAPLAN; Fiscal Year: 2009
    ....
  34. TOBACCO CESSATION IN POSTMENOPAUSAL WOMEN
    Sharon Allen; Fiscal Year: 2001
    ..investigated the different effects of estrogen replacement therapy (ERT) in smoking cessation in postmenopause where the estrogen level is low...
  35. ESTROGEN, MUSCLE BLOOD FLOW AND ENOS POST MENOPAUSE
    Robert Hickner; Fiscal Year: 2000
    ..These investigations will provide valuable research exposure to our undergraduate and graduate programs, and will provide data for subsequent R01 applications. ..
  36. Progestin Levels and Inflammation in Postmenopause
    Peifeng Hu; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  37. Progestin Levels and Inflammation in Postmenopause
    Peifeng Hu; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  38. RISK FACTORS FOR TRANSMENOPAUSAL BONE LOSS
    Alan Jette; Fiscal Year: 1992
    ..the proposed continuation are: 1) What are the normal rates of bone loss in an eight-year period, from pre- to postmenopause in the three sites and what are the independent effects of bone type (cortical vs...
  39. Women's Health Across the Nation - Endocrine Lab
    Daniel McConnell; Fiscal Year: 2003
    ..ovarian markers which have the potential to allow us to hormonally define the menopausal transition and the postmenopause with greater precision (inhibin B, estrone)...
  40. Estrogen Effects on Cholinergic Function in Older Women
    Paul A Newhouse; Fiscal Year: 2010
    ..g. neuroimaging). The over arching goal is to develop information to allow the development of models to potentially predict which women may benefit from the cognitive effects of estradiol after menopause. ..
  41. SLEEP IN OLDER WOMEN--EFFECTS OF ESTROGEN
    KAREN MOE; Fiscal Year: 2000
    ..This study is the first step in a research program investigating the relationship between sex steroids and sleep in older individuals. ..
  42. SLEEP IN OLDER WOMEN--EFFECTS OF ESTROGEN
    KAREN MOE; Fiscal Year: 2001
    ..This study is the first step in a research program investigating the relationship between sex steroids and sleep in older individuals. ..
  43. PILOT--CORONARY DISEASE: POST MENOPAUSE DISEASE MARKERS
    JULIE HOFF; Fiscal Year: 2001
    ..Considering that nearly 50 million American women are now more than 50 years of age, there is not a more important health issue than the primary prevention of CVD. ..
  44. SLEEP IN OLDER WOMEN--EFFECTS OF ESTROGEN
    KAREN MOE; Fiscal Year: 1999
    ..This study is the first step in a research program investigating the relationship between sex steroids and sleep in older individuals. ..
  45. Estrogen Effects on Cholinergic Function in Older Women
    Paul Newhouse; Fiscal Year: 2009
    ..g. neuroimaging). The over arching goal is to develop information to allow the development of models to potentially predict which women may benefit from the cognitive effects of estradiol after menopause. ..
  46. Sex Steroids & Mammographic Density in the Postmenopause
    Gail Greendale; Fiscal Year: 2005
    ..This application proposes to continue work in "Sex Steroids and Mammographic Density in the Postmenopause", a study of the effects of endogenous and exogenous sex steroids on mammographic percent-density...
  47. HORMONE REPLACEMENT AND METABOLIC CARDIOVASCULAR RISK
    Cynthia Sites; Fiscal Year: 2000
    ..In addition, our study may allow physicians to target hormone replacement to women with specific body compositions. ..
  48. Study of Women's Health Across the Nation IV: UC Davis site
    Ellen Gold; Fiscal Year: 2009
    ..characterization to date of the health and the physiologic and psychosocial changes of women from pre- to postmenopause in community based samples...
  49. HORMONE REPLACEMENT AND METABOLIC CARDIOVASCULAR RISK
    Cynthia Sites; Fiscal Year: 2003
    ..In addition, our study may allow physicians to target hormone replacement to women with specific body compositions. ..
  50. HORMONE REPLACEMENT AND METABOLIC CARDIOVASCULAR RISK
    Cynthia Sites; Fiscal Year: 1999
    ..In addition, our study may allow physicians to target hormone replacement to women with specific body compositions. ..
  51. The Study of Women's Health Across the Nation
    Karen A Matthews; Fiscal Year: 2010
    ..characterization to date of the health and the physiologic and psychosocial changes of women from pre- to postmenopause in community based samples...
  52. SWAN NJ-Quantitative and Qualitative cohort Research
    Rachel P Wildman; Fiscal Year: 2010
    ..characterization to date of the health and the physiologic and psychosocial changes of women from pre- to postmenopause in community based samples...
  53. SWAN: Study of Women's Health Across the Nation
    Joel S Finkelstein; Fiscal Year: 2010
    ..characterization to date of the health and the physiologic and psychosocial changes of women from pre- to postmenopause in community based samples...
  54. HORMONE REPLACEMENT AND METABOLIC CARDIOVASCULAR RISK
    Cynthia Sites; Fiscal Year: 2002
    ..In addition, our study may allow physicians to target hormone replacement to women with specific body compositions. ..
  55. HORMONE REPLACEMENT AND METABOLIC CARDIOVASCULAR RISK
    Cynthia Sites; Fiscal Year: 2001
    ..In addition, our study may allow physicians to target hormone replacement to women with specific body compositions. ..
  56. SWAN IV
    MaryFran R Sowers; Fiscal Year: 2010
    ..characterization to date of the health and the physiologic and psychosocial changes of women from pre- to postmenopause in community based samples...
  57. SWAN: Study of Women's Health Across the Nation
    Joel Finkelstein; Fiscal Year: 2009
    ..characterization to date of the health and the physiologic and psychosocial changes of women from pre- to postmenopause in community based samples...
  58. Study of Women's Health Across the NationIV: Chicago Site
    Howard Kravitz; Fiscal Year: 2009
    ..characterization to date of the health and the physiologic and psychosocial changes of women from pre- to postmenopause in community based samples...
  59. Sex Steroids & Mammographic Density in the Postmenopause
    Gail Greendale; Fiscal Year: 2006
    ..This application proposes to continue work in "Sex Steroids and Mammographic Density in the Postmenopause", a study of the effects of endogenous and exogenous sex steroids on mammographic percent-density...
  60. Sex Steroids & Mammographic Density in the Postmenopause
    Gail Greendale; Fiscal Year: 2004
    ..This application proposes to continue work in "Sex Steroids and Mammographic Density in the Postmenopause", a study of the effects of endogenous and exogenous sex steroids on mammographic percent-density...
  61. Sex Steroids & Mammographic Density in the Postmenopause
    Gail Greendale; Fiscal Year: 2007
    ..This application proposes to continue work in "Sex Steroids and Mammographic Density in the Postmenopause", a study of the effects of endogenous and exogenous sex steroids on mammographic percent-density...
  62. SWAN NJ-Quantitative and Qualitative cohort Research
    Nanette Santoro; Fiscal Year: 2009
    ..characterization to date of the health and the physiologic and psychosocial changes of women from pre- to postmenopause in community based samples...
  63. WOMENS HEALTH ACROSS THE NATION--PITTSBURGH
    Karen Matthews; Fiscal Year: 2001
    ..Women will be evaluated at study entry and at 4 (perimenopause) and 12 months (postmenopause) after the cessation of menses...
  64. WOMENS HEALTH ACROSS THE NATION--PITTSBURGH
    Karen Matthews; Fiscal Year: 2002
    ..Women will be evaluated at study entry and at 4 (perimenopause) and 12 months (postmenopause) after the cessation of menses...
  65. WOMENS HEALTH ACROSS THE NATION--PITTSBURGH
    Karen Matthews; Fiscal Year: 2001
    ..Women will be evaluated at study entry and at 4 (perimenopause) and 12 months (postmenopause) after the cessation of menses...
  66. POSTMENOPAUSAL HORMONE THERAPY AND INTRA ABDOMINAL FAT
    Barbara Gower; Fiscal Year: 1999
    ..Significance: HRT reduces risk and incidence of CVD in postmenopausal women. This study will determine if HRT reduces disease risk by influencing fat distribution and decreasing IAF. ..
  67. Ethanol discrimination in aged female monkeys
    Christa M Helms; Fiscal Year: 2010
    ....
  68. Ethanol discrimination in aged female monkeys
    CHRISTA HELMS; Fiscal Year: 2009
    ....
  69. POSTMENOPAUSAL HORMONE THERAPY AND INTRA ABDOMINAL FAT
    Barbara Gower; Fiscal Year: 2000
    ..Significance: HRT reduces risk and incidence of CVD in postmenopausal women. This study will determine if HRT reduces disease risk by influencing fat distribution and decreasing IAF. ..
  70. SEX STEROIDS AND MAMMOGRAM DENSITY IN THE POSTMENOPAUSE
    Gail Greendale; Fiscal Year: 1999
    ..The investigators state that this may serve as the first in a series of investigations that would allow identification of those women at higher risk of developing breast toxicity from postmenopausal supplemental hormone use. ..
  71. SEX STEROIDS AND MAMMOGRAM DENSITY IN THE POSTMENOPAUSE
    Gail Greendale; Fiscal Year: 2000
    ..The investigators state that this may serve as the first in a series of investigations that would allow identification of those women at higher risk of developing breast toxicity from postmenopausal supplemental hormone use. ..
  72. SEX STEROIDS AND MAMMOGRAM DENSITY IN THE POSTMENOPAUSE
    Gail Greendale; Fiscal Year: 2001
    ..The investigators state that this may serve as the first in a series of investigations that would allow identification of those women at higher risk of developing breast toxicity from postmenopausal supplemental hormone use. ..
  73. Womens Health Across the Nation
    Karen Matthews; Fiscal Year: 2007
    ..a baseline and six annual follow-up examinations during which 895 (48%) women will have transitioned to postmenopause. This application requests funding to complete four additional follow-up visits (SWAN III) to allow an ..
  74. Womens Health Across the Nation
    Karen Matthews; Fiscal Year: 2006
    ..a baseline and six annual follow-up examinations during which 895 (48%) women will have transitioned to postmenopause. This application requests funding to complete four additional follow-up visits (SWAN III) to allow an ..
  75. Womens Health Across the Nation
    Karen Matthews; Fiscal Year: 2005
    ..a baseline and six annual follow-up examinations during which 895 (48%) women will have transitioned to postmenopause. This application requests funding to complete four additional follow-up visits (SWAN III) to allow an ..
  76. Womens Health Across the Nation
    Karen Matthews; Fiscal Year: 2004
    ..a baseline and six annual follow-up examinations during which 895 (48%) women will have transitioned to postmenopause. This application requests funding to complete four additional follow-up visits (SWAN III) to allow an ..
  77. TOBACCO CESSATION IN POSTMENOPAUSAL WOMEN
    Sharon Allen; Fiscal Year: 2000
    ..investigated the different effects of estrogen replacement therapy (ERT) in smoking cessation in postmenopause where the estrogen level is low...
  78. TOBACCO CESSATION IN POSTMENOPAUSAL WOMEN
    Sharon Allen; Fiscal Year: 1999
    ..investigated the different effects of estrogen replacement therapy (ERT) in smoking cessation in postmenopause where the estrogen level is low...