Summary: The last menstrual period. Permanent cessation of menses (MENSTRUATION) is usually defined after 6 to 12 months of AMENORRHEA in a woman over 45 years of age. In the United States, menopause generally occurs in women between 48 and 55 years of age.

Top Publications

  1. ncbi Testing ovarian reserve to predict age at menopause
    C B Lambalk
    Division of Reproductive Medicine, Department of Obstetrics Gynaecology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Maturitas 63:280-91. 2009
  2. pmc Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways
    Lisette Stolk
    Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    Nat Genet 44:260-8. 2012
  3. pmc Genome-wide association studies identify loci associated with age at menarche and age at natural menopause
    Chunyan He
    Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Nat Genet 41:724-8. 2009
  4. pmc A validated model of serum anti-müllerian hormone from conception to menopause
    Thomas W Kelsey
    School of Computer Science, University of St Andrews, St Andrews, Scotland, United Kingdom
    PLoS ONE 6:e22024. 2011
  5. ncbi The emergence of the metabolic syndrome with menopause
    Molly C Carr
    Division of Metabolism, Endocrinology, and Nutrition, University of Washington, Seattle, Washington 98195 6426, USA
    J Clin Endocrinol Metab 88:2404-11. 2003
  6. pmc A large-scale candidate gene association study of age at menarche and age at natural menopause
    Chunyan He
    Department of Public Health, Indiana University School of Medicine, Indianapolis, IN, USA
    Hum Genet 128:515-27. 2010
  7. pmc Menopause and the metabolic syndrome: the Study of Women's Health Across the Nation
    Imke Janssen
    Department of Preventive Medicine, Rush University Medical Center, 1700 W Van Buren, Ste 470, Chicago, IL 60612, USA
    Arch Intern Med 168:1568-75. 2008
  8. ncbi Severe intergenerational reproductive conflict and the evolution of menopause
    Mirkka Lahdenperä
    Section of Ecology, Department of Biology, University of Turku, Turku, Finland
    Ecol Lett 15:1283-90. 2012
  9. ncbi Postmenopausal status and early menopause as independent risk factors for cardiovascular disease: a meta-analysis
    Femke Atsma
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Menopause 13:265-79. 2006
  10. pmc Reproductive history and oral contraceptive use in relation to risk of triple-negative breast cancer
    Amanda I Phipps
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    J Natl Cancer Inst 103:470-7. 2011

Detail Information

Publications345 found, 100 shown here

  1. ncbi Testing ovarian reserve to predict age at menopause
    C B Lambalk
    Division of Reproductive Medicine, Department of Obstetrics Gynaecology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Maturitas 63:280-91. 2009
    In modern society with women delaying pregnancy, predicting the age of the natural menopause with its preceding infertility will allow making informed choices about when to try starting to have children...
  2. pmc Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways
    Lisette Stolk
    Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    Nat Genet 44:260-8. 2012
    To newly identify loci for age at natural menopause, we carried out a meta-analysis of 22 genome-wide association studies (GWAS) in 38,968 women of European descent, with replication in up to 14,435 women...
  3. pmc Genome-wide association studies identify loci associated with age at menarche and age at natural menopause
    Chunyan He
    Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Nat Genet 41:724-8. 2009
    Age at menarche and age at natural menopause are associated with causes of substantial morbidity and mortality such as breast cancer and cardiovascular disease...
  4. pmc A validated model of serum anti-müllerian hormone from conception to menopause
    Thomas W Kelsey
    School of Computer Science, University of St Andrews, St Andrews, Scotland, United Kingdom
    PLoS ONE 6:e22024. 2011
    ..e. the ovarian reserve, and be of value in predicting reproductive lifespan. A full description of AMH production up to the menopause has not been previously reported.
  5. ncbi The emergence of the metabolic syndrome with menopause
    Molly C Carr
    Division of Metabolism, Endocrinology, and Nutrition, University of Washington, Seattle, Washington 98195 6426, USA
    J Clin Endocrinol Metab 88:2404-11. 2003
    ..The prevalence of the metabolic syndrome increases with menopause and may partially explain the apparent acceleration in CVD after menopause...
  6. pmc A large-scale candidate gene association study of age at menarche and age at natural menopause
    Chunyan He
    Department of Public Health, Indiana University School of Medicine, Indianapolis, IN, USA
    Hum Genet 128:515-27. 2010
    ..GWA) studies have identified several novel genetic loci associated with age at menarche and age at natural menopause. However, the stringent significance threshold used in GWA studies potentially led to false negatives and true ..
  7. pmc Menopause and the metabolic syndrome: the Study of Women's Health Across the Nation
    Imke Janssen
    Department of Preventive Medicine, Rush University Medical Center, 1700 W Van Buren, Ste 470, Chicago, IL 60612, USA
    Arch Intern Med 168:1568-75. 2008
    ..Little is known about why. We hypothesized that the incidence of the MetS increases with progression through menopause and that this increase is explained by the progressive androgenicity of the hormonal milieu.
  8. ncbi Severe intergenerational reproductive conflict and the evolution of menopause
    Mirkka Lahdenperä
    Section of Ecology, Department of Biology, University of Turku, Turku, Finland
    Ecol Lett 15:1283-90. 2012
    Human menopause is ubiquitous among women and is uninfluenced by modernity. In addition, it remains an evolutionary puzzle: studies have largely failed to account for diminishing selection on reproduction beyond 50 years...
  9. ncbi Postmenopausal status and early menopause as independent risk factors for cardiovascular disease: a meta-analysis
    Femke Atsma
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Menopause 13:265-79. 2006
    ..deficiency of endogenous estrogens is suggested to enhance cardiovascular disease risk and related death after menopause. The aim was to obtain valid estimates of the cardiovascular disease risk associated with postmenopausal status ..
  10. pmc Reproductive history and oral contraceptive use in relation to risk of triple-negative breast cancer
    Amanda I Phipps
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    J Natl Cancer Inst 103:470-7. 2011
    ..Hormonally mediated risk factors may be differentially related to risk of triple-negative and ER+ breast cancers...
  11. pmc Loci at chromosomes 13, 19 and 20 influence age at natural menopause
    Lisette Stolk
    Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    Nat Genet 41:645-7. 2009
    We conducted a genome-wide association study for age at natural menopause in 2,979 European women and identified six SNPs in three loci associated with age at natural menopause: chromosome 19q13.4 (rs1172822; -0...
  12. pmc Human ovarian reserve from conception to the menopause
    W Hamish B Wallace
    Department of Reproductive and Developmental Sciences, Division of Child Life and Health, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 5:e8772. 2010
    ..of non-growing follicles (NGFs) established before birth that decline with increasing age culminating in the menopause at 50-51 years...
  13. ncbi The timing of natural menopause in Poland and associated factors
    Maria Kaczmarek
    Institute of Anthropology, The Adam Mickiewicz University, Collegium Biologicum, Umultowska 89, 61 614 Poznan, Poland
    Maturitas 57:139-53. 2007
    The outcome of interest was the assessment of age at natural menopause and the variables hypothesized as covariates of age at menopause were indicators of demographic and social status, characteristics of the reproductive history and ..
  14. ncbi The menopausal transition was associated in a prospective study with decreased health functioning in women who report menopausal symptoms
    Meena Kumari
    International Centre for Health and Society, Department of Epidemiology and Public Health, Royal Free and University College London Medical School, 1 19 Torrington Place, London WC1 6BT, UK
    J Clin Epidemiol 58:719-27. 2005
    ..To examine change in health functioning as women progress through the menopausal transition...
  15. ncbi Predictors of the timing of natural menopause in the Multiethnic Cohort Study
    Katherine Delellis Henderson
    Department of Cancer Etiology, City of Hope National Medical Center, Duarte, CA 91010, USA
    Am J Epidemiol 167:1287-94. 2008
    The timing of natural menopause has implications for several health endpoints; in particular, it is a risk factor for breast cancer...
  16. ncbi Sex, menopause, metabolic syndrome, and all-cause and cause-specific mortality--cohort analysis from the Third National Health and Nutrition Examination Survey
    Jou Wei Lin
    Cardiovascular Center and Health Management Center, National Taiwan University Hospital, Yun Lin branch, Dou Liou City, Taiwan 640
    J Clin Endocrinol Metab 95:4258-67. 2010
    ..This study assessed the mortality risk associated with metabolic syndrome (MetS) for participants from the Third National Health and Nutrition Examination Survey...
  17. ncbi Understanding weight gain at menopause
    S R Davis
    Women s Health Research Program, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia
    Climacteric 15:419-29. 2012
    The aim of this review was to summarize the literature regarding the impact of the menopause transition on body weight and body composition.
  18. ncbi Age at menopause, cause-specific mortality and total life expectancy
    Marlies E Ossewaarde
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Epidemiology 16:556-62. 2005
    A later menopause has been associated with a decreased cardiovascular risk but with an increased risk for breast and endometrial cancer. The net effect on mortality is unclear...
  19. ncbi How can female germline stem cells contribute to the physiological neo-oogenesis in mammals and why menopause occurs?
    Antonin Bukovsky
    Department of Obstetrics and Gynecology, The University of Tennessee College of Medicine and Graduate School of Medicine, Knoxville, Tennessee 37920, USA
    Microsc Microanal 17:498-505. 2011
    ..whether neo-oogenesis from ovarian somatic stem cells is physiologically involved in follicular renewal and why menopause occurs...
  20. ncbi Associations of hormones and menopausal status with depressed mood in women with no history of depression
    Ellen W Freeman
    Department of Obstetrics Gynecology, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    Arch Gen Psychiatry 63:375-82. 2006
    Whether depressed mood reported in the transition to menopause by women with no history of depression is associated with menopausal status and changes in reproductive hormones is controversial and lacks scientific information.
  21. ncbi The connections between general and reproductive senescence and the evolutionary basis of menopause
    Thomas B L Kirkwood
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
    Ann N Y Acad Sci 1204:21-9. 2010
    ..This is most striking in the case of the human menopause, for which a particular combination of biological and sociobiological factors appear to be responsible.
  22. ncbi The effect of menopause on the metabolic syndrome among Korean women: the Korean National Health and Nutrition Examination Survey, 2001
    Hee Man Kim
    Korean Association of Public Health Doctor, Chungcheongbuk Do, Korea
    Diabetes Care 30:701-6. 2007
    ..This study examined the effect of menopausal status on the risk of the metabolic syndrome in Korean women...
  23. ncbi Anti-mullerian hormone predicts menopause: a long-term follow-up study in normoovulatory women
    S L Broer
    Department of Reproductive Medicine and Gynecology, Division of Woman and Baby, University Medical Center Utrecht, GA Utrecht, The Netherlands
    J Clin Endocrinol Metab 96:2532-9. 2011
    It has been hypothesized that a fixed interval exists between age at natural sterility and age at menopause. Both events show considerable individual variability, with a range of 20 yr...
  24. ncbi The effects of body mass index on age at menopause
    M Akahoshi
    Department of Clinical Studies, Radiation Effects Research Foundation, Nagasaki, Japan
    Int J Obes Relat Metab Disord 26:961-8. 2002
    We examined which of body mass index (BMI, kg/m(2)), serum cholesterol (mg/dl), or systolic blood pressure (SBP, mm Hg) affected age at natural menopause.
  25. ncbi Literature review of instruments to assess health-related quality of life during and after menopause
    Y F Zöllner
    Solvay Pharmaceuticals, Hannover, Germany
    Qual Life Res 14:309-27. 2005
    b>Menopause is a physiological event occurring in women at about the age of 50...
  26. pmc A cohort effect of the sexual revolution may be masking an increase in human papillomavirus detection at menopause in the United States
    Patti E Gravitt
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD21205, USA
    J Infect Dis 207:272-80. 2013
  27. ncbi Factors associated with the age of natural menopause and menopausal symptoms in Chinese women
    Lin Li
    The State Key Laboratory of Reproductive Medicine, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, People s Republic of China
    Maturitas 73:354-60. 2012
    To investigate the factors associated with the age of natural menopause and menopausal symptoms in a large population of Chinese middle-aged women.
  28. ncbi Is age at menopause increasing across Europe? Results on age at menopause and determinants from two population-based studies
    Julia Dratva
    Institute of Social and Preventive Medicine, University of Basel, Basel, Switzerland
    Menopause 16:385-94. 2009
    To investigate the variability and determinants of menopause age in two European cohort studies, the European Respiratory Health Survey and the Swiss Air Pollution and Lung Disease in Adults Cohort.
  29. pmc Factors related to age at natural menopause: longitudinal analyses from SWAN
    Ellen B Gold
    University of California Davis School of Medicine, One Shields Avenue, Davis, CA 95616, USA
    Am J Epidemiol 178:70-83. 2013
    Early age at the natural final menstrual period (FMP) or menopause has been associated with numerous health outcomes and might be a marker of future ill health...
  30. ncbi Determinants of age at menopause in women attending menopause clinics in Italy
    Fabio Parazzini
    Istituto di Ricerche Farmacologiche Mario Negriî, Via Eritrea, 62 20157 Milano, Italy
    Maturitas 56:280-7. 2007
    We analysed the mean age at menopause and its determinants in 31,000 women attending menopause clinics in Italy.
  31. ncbi Population-based study of age at menopause and ultrasound assessed carotid atherosclerosis: The Tromsø Study
    O Joakimsen
    Institute of Community Medicine, University of Tromso, N 9037, Tromso, Norway
    J Clin Epidemiol 53:525-30. 2000
    Early menopause has been associated with higher prevalence and incidence of cardiovascular disease and death than late menopause, indicating that early loss of ovarian function and subsequent deficiency of estrogen may promote such ..
  32. ncbi Breast cancer incidence, 1980-2006: combined roles of menopausal hormone therapy, screening mammography, and estrogen receptor status
    Andrew G Glass
    Oncology Research, Center for Health Research, Kaiser Permanente Northwest, 3800 N Interstate Ave, Portland, OR 97227, USA
    J Natl Cancer Inst 99:1152-61. 2007
    ..We examined the potential association between menopausal hormone therapy use and recent changes in breast cancer incidence...
  33. ncbi Factors associated with age of onset and type of menopause in a cohort of UK women
    Alida J Pokoradi
    Centre of Academic Primary Care, University of Aberdeen, Aberdeen, Scotland, United Kingdom
    Am J Obstet Gynecol 205:34.e1-13. 2011
    We sought to describe the pattern of age at menopause and factors associated with type of menopause.
  34. ncbi A polymorphism in the AMH type II receptor gene is associated with age at menopause in interaction with parity
    Marlies E Kevenaar
    Department of Internal Medicine, Room Ee532, PO Box 2040, Erasmus MC, 3000 CA Rotterdam, The Netherlands
    Hum Reprod 22:2382-8. 2007
    ..women AMH signaling also regulates the usage of the primordial follicle pool and hence influences the onset of menopause. Since age at menopause has a strong genetic component, we investigated the role of AMH signaling using a ..
  35. ncbi Effect of the gonadotropin-releasing hormone analogue triptorelin on the occurrence of chemotherapy-induced early menopause in premenopausal women with breast cancer: a randomized trial
    Lucia Del Mastro
    S S Sviluppo Terapie Innovative, Oncologia Medica A, Istituto Nazionale per la Ricerca sul Cancro, L go R Benzi 10, 16132 Genova, Italy
    JAMA 306:269-76. 2011
    ..Premenopausal patients with breast cancer are at high risk of premature ovarian failure induced by systemic treatments, but no standard strategies for preventing this adverse effect are yet available...
  36. ncbi Vascular consequences of menopause and hormone therapy: importance of timing of treatment and type of estrogen
    Raghvendra K Dubey
    Center for Clinical Pharmacology, University of Pittsburgh, Pittsburgh, PA, USA
    Cardiovasc Res 66:295-306. 2005
    ..replacement therapy (HRT) that would be effective in delaying vascular remodeling leading to CVD following menopause. In this review we provide an overview of the impact of menopause and estrogen deficiency on vascular remodeling ..
  37. ncbi Antral follicle counts are related to age at natural fertility loss and age at menopause
    Frank J Broekmans
    Department of Reproductive Medicine, Division of Obstetrics, Gynecology and Neonatology, University Medical Center Utrecht, 3584 CX, The Netherlands
    Menopause 11:607-14. 2004
    ..This may represent differences in actual reproductive age among women. This hypothesis was tested by cohort comparison for distribution of age at occurrence of reproductive events...
  38. ncbi Menopausal symptoms and quality of life during the menopausal transition in Sri Lankan women
    Himansu Waidyasekera
    Department of Physiology, Faculty of Medical Sciences, University of Sri Jayewardenepura, Nuggegoda, Sri Lanka
    Menopause 16:164-70. 2009
    ..To assess the prevalence of menopausal symptoms in a population of Sri Lankan women and the relationship with their health-related quality of life...
  39. ncbi Relationship of serum antimüllerian hormone concentration to age at menopause
    J van Disseldorp
    University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Endocrinol Metab 93:2129-34. 2008
    ..However, AMH, unlike antral follicle counts, has not been tested as yet as a predictor of reproductive status. By relating AMH levels to the age distribution of reproductive events like onset of menopause, we tested this hypothesis.
  40. ncbi Assessment of the variation in menopausal symptoms with age, education and working/non-working status in north-Indian sub population using menopause rating scale (MRS)
    V Kakkar
    University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India
    Maturitas 57:306-14. 2007
    To study the variation of the menopause rating scale (MRS) scores with age, working/non-working and educated/uneducated status in a cohort of north-Indian subpopulation and to look for the possible reasons for the incurred variations...
  41. pmc Psychosocial and socioeconomic burden of vasomotor symptoms in menopause: a comprehensive review
    Wulf H Utian
    North American Menopause Society, 5900 Lander Brook Drive, Mayfield Heights, OH 44124, USA
    Health Qual Life Outcomes 3:47. 2005
    Many women experience vasomotor symptoms at or around the time of menopause. Hot flushes and night sweats are considered primary menopausal symptoms that may also be associated with sleep and mood disturbances, as well as decreased ..
  42. ncbi Menopause, physical activity, and body composition/fat distribution in midlife women
    Barbara Sternfeld
    Division of Research, Kaiser Permanente, Oakland, CA 94611, USA
    Med Sci Sports Exerc 37:1195-202. 2005
    Hormonal changes associated with menopause, chronological aging, and lifestyle, specifically physical activity, may all influence the changes in body composition and fat distribution experienced by midlife women...
  43. pmc Endothelial cellular senescence is inhibited by nitric oxide: implications in atherosclerosis associated with menopause and diabetes
    Toshio Hayashi
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Tsuruma cho 65, Showa Ku, Nagoya 466 8550, Japan
    Proc Natl Acad Sci U S A 103:17018-23. 2006
    ..We suggest that the delay in endothelial senescence through NO and/or eNOS activation may have clinical utility in the treatment of atherosclerosis in the elderly...
  44. ncbi Factors associated with age at natural menopause in a multiethnic sample of midlife women
    E B Gold
    Department of Epidemiology and Preventive Medicine, University of California, Davis, Davis, CA 95616, USA
    Am J Epidemiol 153:865-74. 2001
    An unprecedented number of women will experience menopause in the next decade. Although the timing of menopause affects long-term disease risk, little is known about factors that affect this timing...
  45. ncbi Web-based survey of fertility issues in young women with breast cancer
    Ann H Partridge
    Dana Farber Cancer Institute, 44 Binney St, D1210, Boston, MA 02115, USA
    J Clin Oncol 22:4174-83. 2004
    ..Young women with breast cancer often seek advice about whether treatment will affect their fertility. We sought to gain a better understanding of women's attitudes about fertility and how these concerns affect decision making...
  46. ncbi Menopause is an independent predictor of metabolic syndrome in Iranian women
    Radina Eshtiaghi
    AJA University of Medical Science, 3th floor, Endocrine Research Center, Emam Reza Hospital 501 AJA, Etemad Zadeh Ave, Fatemi St, Tehran, Iran
    Maturitas 65:262-6. 2010
    ..Postmenopausal status may explain in part the cause of acceleration of CVD with aging. The purpose of this study was to investigate the relation of menopause and metabolic syndrome independent of aging among Iranian women.
  47. pmc Estrogen anti-inflammatory activity in brain: a therapeutic opportunity for menopause and neurodegenerative diseases
    Elisabetta Vegeto
    Centre of Excellence on Neurodegenerative Disease, University of Milan, Via Balzaretti, 9 20133 Milan, Italy
    Front Neuroendocrinol 29:507-19. 2008
    ..This review summarises the evidence for the involvement of microglia in neuroinflammation and the anti-inflammatory activity played by estrogens specifically in microglia...
  48. ncbi Changes in proinflammatory cytokine activity after menopause
    Johannes Pfeilschifter
    Department of Internal Medicine, Berufsgenossenschaftliche Kliniken Bergmannsheil, University of Bochum, D 44789 Bochum, Germany
    Endocr Rev 23:90-119. 2002
    There is now a large body of evidence suggesting that the decline in ovarian function with menopause is associated with spontaneous increases in proinflammatory cytokines...
  49. pmc The timing of the age at which natural menopause occurs
    Ellen B Gold
    Department of Public Health Sciences and Division of Epidemiology, School of Medicine, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    Obstet Gynecol Clin North Am 38:425-40. 2011
    The timing of natural menopause is a clinically important indicator of longevity and risk of morbidity and mortality. Demographic, menstrual, reproductive, familial, genetic, and lifestyle factors seem to be important in this timing...
  50. ncbi Hormonal changes during menopause
    Farook Al-Azzawi
    Gynaecology Research Unit, University Hospitals of Leicester, Victoria Building, Leicester Royal Infirmary, Leicester LE1 5WW, United Kingdom
    Maturitas 63:135-7. 2009
    Ovarian senescence occurs gradually during the fourth and fifth decades of life, leading to menopause at an average age of about 51 years...
  51. pmc Weight gain since menopause and its associations with weight loss maintenance in obese postmenopausal women
    M Senechal
    Research Centre on Aging, Health and Social Services Centre, University Institute of Geriatrics of Sherbrooke, Sherbrooke, QC
    Clin Interv Aging 6:221-5. 2011
    To examine the association between weight gain since menopause and weight regain after a weight loss program.
  52. pmc Executive summary of the Stages of Reproductive Aging Workshop + 10: addressing the unfinished agenda of staging reproductive aging
    Sioban D Harlow
    Department of Epidemiology, University of Michigan, 1415 Washington Heights, Ann Arbor MI 48109, USA
    J Clin Endocrinol Metab 97:1159-68. 2012
    ..The 2011 STRAW + 10 reviewed advances in understanding of the critical changes in hypothalamic-pituitary-ovarian function that occur before and after the final menstrual period...
  53. ncbi Menopause as risk factor for oxidative stress
    Martha A Sánchez-Rodríguez
    Unidad de Investigación en Gerontología, Facultad de Estudios Superiores Zaragoza, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico
    Menopause 19:361-7. 2012
    The aim of this study was to determine the influence of menopause (hypoestrogenism) as a risk factor for oxidative stress.
  54. pmc Anti-mullerian hormone as a predictor of time to menopause in late reproductive age women
    Ellen W Freeman
    Department of Obstetrics Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Endocrinol Metab 97:1673-80. 2012
    ..Anti-mullerian hormone (AMH) has emerged as a marker of ovarian reserve and a possible surrogate measure of reproductive aging...
  55. ncbi Menopause
    Heidi D Nelson
    Oregon Evidence Based Practice Center, Department of Medical Informatics and Clinical Epidemiology, OR, USA
    Lancet 371:760-70. 2008
    b>Menopause is the time of life when menstrual cycles cease, and is caused by reduced secretion of the ovarian hormones oestrogen and progesterone...
  56. ncbi Menopause does not affect blood pressure and risk profile, and menopausal women do not become similar to men
    Edoardo Casiglia
    Department of Clinical and Experimental Medicine, University of Padova, Padova, Italy
    J Hypertens 26:1983-92. 2008
    b>Menopause is considered to be a cardiovascular risk factor, but this belief is based on opinions rather than on evidence. Confounding effects of age are often neglected.
  57. pmc Anti-mullerian hormone and inhibin B in the definition of ovarian aging and the menopause transition
    MaryFran R Sowers
    Department of Epidemiology, School of Public Health, University of Michigan, 109 Observatory, Room 1846, Ann Arbor, Michigan 48109, USA
    J Clin Endocrinol Metab 93:3478-83. 2008
    The objective of the study was to determine whether anti-Mullerian hormone (AMH) and inhibin B are viable endocrine biomarkers for framing the menopause transition from initiation to the final menstrual period (FMP).
  58. pmc Dietary and lifestyle predictors of age at natural menopause and reproductive span in the Shanghai Women's Health Study
    Tsogzolmaa Dorjgochoo
    Department of Medicine, Vanderbilt Epidemiology Center, School of Medicine, Vanderbilt University and Vanderbilt Ingram Cancer Center, Nashville, TN 37203 1738, USA
    Menopause 15:924-33. 2008
    Modifiable factors predicting the onset of menopause, a transition with important implications for women's health, have not been fully characterized...
  59. ncbi Age at natural menopause and risk of cardiovascular disease
    F B Hu
    Department of Nutrition, Harvard School of Public Health, Boston, Mass 02115, USA
    Arch Intern Med 159:1061-6. 1999
    Early natural menopause has been postulated to increase the risk of cardiovascular disease.
  60. ncbi Health-related quality of life and healthcare resource utilization in Taiwanese women with menopausal symptoms: a nation-wide survey
    Yuh Kae Shyu
    Graduate Institute of Nursing, Taipei Medical University, Taipei, Taiwan
    J Nurs Res 20:208-18. 2012
    Menopausal experience differs among women with different cultural and ethnic backgrounds and may impact quality of life. Some women with severe menopausal symptoms seek medical help to alleviate menopause-related symptoms.
  61. ncbi Vitamin D and its binding protein Gc: long-term variability in peri- and postmenopausal women with and without hormone replacement therapy
    L Rejnmark
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus Sygehus, Aarhus, Denmark
    Scand J Clin Lab Invest 66:227-38. 2006
    ..The purpose of this study was to investigate the variability in individual plasma 25OHD- and vitamin D-binding protein- (Gc) levels over a 5-year period in postmenopausal women with and without hormone replacement therapy (HRT)...
  62. ncbi Treatment of menopausal symptoms: what shall we do now?
    Martha Hickey
    University of Western Australia, School of Women s and Infants Health, King Edward Memorial Hospital, Subiaco, Western Australia 6008, Australia
    Lancet 366:409-21. 2005
    ..There is not enough evidence that any of the complementary therapies available are any better than placebo for menopausal vasomotor symptoms, and few safety data exist...
  63. ncbi Meta-analysis suggests that smoking is associated with an increased risk of early natural menopause
    Lu Sun
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, China
    Menopause 19:126-32. 2012
    Age at natural menopause (ANM) is usually defined as the age at the last menstrual bleeding followed by the absence of menses for 12 consecutive months...
  64. ncbi HIV infection, drug use, and onset of natural menopause
    Ellie E Schoenbaum
    Department of Epidemiology and Population Health, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, New York 10467, USA
    Clin Infect Dis 41:1517-24. 2005
    To study the relationship of HIV infection and drug use with the onset of natural menopause.
  65. pmc Major depression during and after the menopausal transition: Study of Women's Health Across the Nation (SWAN)
    J T Bromberger
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Psychol Med 41:1879-88. 2011
    ..for major depression during the menopausal transition or immediately thereafter is increased relative to pre-menopause. We aimed to examine whether the odds of experiencing major depression were greater when women were peri- or ..
  66. ncbi Effect of dietary soy intake on breast cancer risk according to menopause and hormone receptor status
    Y A Cho
    Cancer Epidemiology Branch, Division of Cancer Epidemiology and Management, Research Institute, National Cancer Center, Gyeonggi Do, South Korea
    Eur J Clin Nutr 64:924-32. 2010
    ..Although high soy consumption may be associated with lower breast cancer risk in Asian populations, findings from epidemiological studies have been inconsistent...
  67. ncbi Associations of depression with the transition to menopause
    Ellen W Freeman
    Department of Obstetrics Gynecology, University of Pennsylvania, Philadelphia, PA, USA
    Menopause 17:823-7. 2010
    The aims of this study were to identify the risk of depression in the transition to menopause in women with and without a history of depression and to consider that the changing hormonal milieu is one of multiple risk factors for ..
  68. ncbi The age at menopause and associated factors at the health center area in Ankara, Turkey
    Oya Ozdemir
    Department of Public Health, Ankara University School of Medicine, Ali Dede Sokak No 6 28, 06540 Aş aği Ayranci, Ankara, Turkey
    Maturitas 49:211-9. 2004
    This study is performed in one health center area in Ankara, Turkey on a women population of 50-65 years in order to demonstrate menopausal status of women, age at menopause and factors related with the age at menopause.
  69. ncbi Associations between age at menarche and menopause with cardiovascular disease, diabetes, and osteoporosis in Chinese women
    Changsheng Qiu
    Department of Osteology, Wuyishan Municipal Hospital, Fujian Provincial Hospital, Wuyishan, 354300, China
    J Clin Endocrinol Metab 98:1612-21. 2013
    Ages at menarche and menopause are associated with cardiovascular disease (CVD), diabetes, and osteoporosis in Caucasian women, but associations remain unexplored in Chinese women.
  70. ncbi International variability of ages at menarche and menopause: patterns and main determinants
    F Thomas
    CEPM, UMR CNRS-IRD 9926, , Montpellier, France
    Hum Biol 73:271-90. 2001
    The purpose of this study was to review published studies on the variability of age at menarche and age at menopause throughout the world, and to identify the main causes for age variation in the timing of these events...
  71. pmc Down-regulation of serum gonadotropins is as effective as estrogen replacement at improving menopause-associated cognitive deficits
    Kathryn J Bryan
    Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio, USA
    J Neurochem 112:870-81. 2010
    ..These findings provide a potential novel protective strategy to treat menopause/age-related cognitive decline and/or prevent the development of AD.
  72. ncbi Skin climacteric aging and hormone replacement therapy
    Pascale Quatresooz
    Department of Dermatopathology, University Hospital of Liege, Liege, Belgium
    J Cosmet Dermatol 5:3-8. 2006
    A gender perspective is indispensable for a full understanding of aging. Menopause is a turning point in women's lives...
  73. pmc Menopause and risk of diabetes in the Diabetes Prevention Program
    Catherine Kim
    Department of Medicine, University of Michigan, Ann Arbor, MI, USA
    Menopause 18:857-68. 2011
    The study objectives were to examine the association between menopause status and diabetes risk among women with glucose intolerance and to determine if menopause status modifies response to diabetes prevention interventions.
  74. pmc Nonlinear association between CGG repeat number and age of menopause in FMR1 premutation carriers
    Sarah Ennis
    Genetic Epidemiology and Bioinformatics Group, Human Genetics Division, University of Southampton, Southampton, UK
    Eur J Hum Genet 14:253-5. 2006
    ..We present evidence for a nonlinear association between menopause age and premutation size suggesting that premutations in the mid-size range are at greatest risk for POF, while ..
  75. pmc Oral contraceptive use and reproductive factors and risk of ovarian cancer in the European Prospective Investigation into Cancer and Nutrition
    K K Tsilidis
    Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK
    Br J Cancer 105:1436-42. 2011
    ..It is well established that parity and use of oral contraceptives reduce the risk of ovarian cancer, but the associations with other reproductive variables are less clear...
  76. ncbi Evidence for a secular trend in menopausal age: a population study of women in Gothenburg
    Kerstin Rödström
    Department of Primary Health Care, Sahlgrenska Academy at Goteborg University, Sweden
    Menopause 10:538-43. 2003
    To describe secular trends in age of natural menopause.
  77. doi Menopause and hypertension: an age-old debate
    Megan Coylewright
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Hypertension 51:952-9. 2008
  78. pmc Menopause, the metabolic syndrome, and mind-body therapies
    Kim E Innes
    Center for the Study of Complementary and Alternative Therapies, University of Virginia Health Systems, Charlottesville, VA 22908 0905, USA
    Menopause 15:1005-13. 2008
    Cardiovascular disease risk rises sharply with menopause, likely due to the coincident increase in insulin resistance and related atherogenic changes that together comprise the metabolic or insulin resistance syndrome, a cluster of ..
  79. ncbi What causes hot flushes? The neuroendocrine origin of vasomotor symptoms in the menopause
    Winfried G Rossmanith
    Department of Obstetrics and Gynecology, Diakonissenkrankenhaus 28, D 76199 Karlsruhe, Germany
    Gynecol Endocrinol 25:303-14. 2009
    Vasomotor symptoms (VMS) such as hot flushes and night sweats are frequently encountered during menopause and can greatly reduce the quality of life...
  80. ncbi Women's voices in the menopause: results from an international survey on vaginal atrophy
    Rossella E Nappi
    Research Center for Reproductive Medicine, Department of Morphological, Eidological and Clinical Sciences, University of Pavia, Pavia, Italy
    Maturitas 67:233-8. 2010
    ..To consider issues relating to vaginal atrophy via an international survey...
  81. ncbi Heritability of age at natural menopause in the Framingham Heart Study
    Joanne M Murabito
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mount Wayte Avenue, Suite 2, Framingham, Massachusetts 01702 5827, USA
    J Clin Endocrinol Metab 90:3427-30. 2005
    Twin registries and family history studies provide evidence that genetic factors contribute to the onset of menopause, but heritability estimates in population-based samples are limited...
  82. ncbi Current alternative and complementary therapies used in menopause
    Veronica Chi Ken Wong
    Department of Obstetrics and Gynaecology, Liverpool Hospital, Faculty of Medicine, University of New South Wales, Sydney, Australia
    Gynecol Endocrinol 25:166-74. 2009
    ..To determine the efficacy and safety of common complementary and alternative medicine (CAM) therapies used to relieve the menopausal symptoms...
  83. ncbi Ovarian stem cell niche and follicular renewal in mammals
    Antonin Bukovsky
    Institute of Biotechnology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Anat Rec (Hoboken) 294:1284-306. 2011
    ..The parthenotes produce embryonic stem cells derived from inner cell mass, and these cells can serve as autologous pluripotent stem cells...
  84. ncbi Surgical menopause increases salt sensitivity of blood pressure
    Ivonne Hernandez Schulman
    Veterans Affairs Medical Center, Division of Nephrology, Hypertension and Vascular Biology Institute, University of Miami Miller School of Medicine, FL, USA
    Hypertension 47:1168-74. 2006
    ..The prevalence of HTN increases after menopause. The aim of this study was to investigate prospectively whether the loss of ovarian hormones increases the ..
  85. ncbi Longitudinal changes in dietary intake in Scottish women around the menopause: changes in dietary pattern result in minor changes in nutrient intake
    Helen M Macdonald
    Centre for Nutrition and Food Safety, School of Biomedical and Molecular Sciences, University of Surrey, Guildford, Surrey, GU2 7XH, UK
    Public Health Nutr 8:409-16. 2005
    ..To examine dietary change that has occurred over 5 to 6 years...
  86. ncbi A menopause-specific quality of life questionnaire: development and psychometric properties
    J R Hilditch
    Department of Family and Community Medicine, Sunnybrook Health Science Centre, University of Toronto, North York, Ontario, Canada
    Maturitas 24:161-75. 1996
    OBJECTIVE: To develop a condition-specific quality of life questionnaire for the menopause with documented psychometric properties, based on women's experience...
  87. ncbi From menarche to menopause: exploring the underlying biology of depression in women experiencing hormonal changes
    Darlene Deecher
    Wyeth Research, 500 Arcola Rd, RN3164, Collegeville, PA 19426, USA
    Psychoneuroendocrinology 33:3-17. 2008
    ..A testable hypothesis will be proposed to advance our understanding of hormonal effects on mood...
  88. ncbi Symptoms reported by women in midlife: menopausal transition or aging?
    Janneke Berecki-Gisolf
    Faculty of Health Sciences, School of Population Health, University of Queensland, Herston, Australia
    Menopause 16:1021-9. 2009
    ..The aim of this study was to determine which symptoms commonly reported by women at midlife are associated with the menopausal transition, after adjusting for aging, life events, sociodemographics, and lifestyle factors...
  89. pmc Lipids, menopause, and early atherosclerosis in Study of Women's Health Across the Nation Heart women
    Genevieve A Woodard
    University of Pittsburgh Graduate School of Public Health, Department of Epidemiology, Pittsburgh, PA 15217, USA
    Menopause 18:376-84. 2011
    The risk of cardiovascular disease increases after menopause. Recent evidence suggests that it is possible for high-density lipoprotein (HDL) to become proatherogenic or dysfunctional in certain situations...
  90. pmc Synaptic characteristics of dentate gyrus axonal boutons and their relationships with aging, menopause, and memory in female rhesus monkeys
    Yuko Hara
    Fishberg Department of Neuroscience and Kastor Neurobiology of Aging Laboratories, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 31:7737-44. 2011
    ..We recently reported that rhesus monkeys display age- and menopause-related recognition memory impairment on a hippocampus-reliant test [delayed nonmatching-to-sample (DNMS)]...
  91. ncbi Clinical studies of red clover (Trifolium pratense) dietary supplements in menopause: a literature review
    Nancy L Booth
    UIC NIH Center for Botanical Dietary Supplements Research, Program for Collaborative Research in the Pharmaceutical Sciences PCRPS, University of Illinois at Chicago, Chicago, IL 60612, USA
    Menopause 13:251-64. 2006
    ..botanical dietary supplements have received much attention recently for their potential use in the treatment of menopause symptoms, maintenance/improvement of bone and cardiovascular health, and reported benign effects on the breast ..
  92. ncbi Evaluation of a group cognitive behavioural intervention for women suffering from menopausal symptoms following breast cancer treatment
    Myra S Hunter
    NIHR Biomedical Research Centre, Institute of Psychiatry, King s College London, Guy s Campus, London Bridge, London, UK
    Psychooncology 18:560-3. 2009
    ..To evaluate a group cognitive behavioural intervention to alleviate menopausal symptoms in women who have had treatment for breast cancer...
  93. pmc Oophorectomy, menopause, estrogen, and cognitive aging: the timing hypothesis
    Walter A Rocca
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Neurodegener Dis 7:163-6. 2010
    ..The concept of neuroprotective effects of estrogen in women remains controversial...
  94. pmc Menopause status and attitudes in a Turkish midlife female population: an epidemiological study
    Unal Ayranci
    Kurtulus Aile Sagligi Merkezi, Vatan Cd, 12 A Eskişehir, Turkey
    BMC Womens Health 10:1. 2010
    It is a well accepted status that socio-cultural characteristics may affect the onset of menopause and its characteristics...
  95. ncbi A cognitive model of menopausal hot flushes and night sweats
    Myra S Hunter
    Department of Psychology, Institute of Psychiatry at Guy s, King s College London, London, UK
    J Psychosom Res 69:491-501. 2010
    Hot flushes and night sweats (HF/NS) are commonly experienced by mid-aged women during the menopause transition...
  96. pmc Menopause, postmenopausal hormone use and serum uric acid levels in US women--the Third National Health and Nutrition Examination Survey
    A Elisabeth Hak
    Department of Immunology, Erasmus MC University Medical Center, Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands
    Arthritis Res Ther 10:R116. 2008
    ..We evaluated and quantified the potential independent association between menopause, postmenopausal hormone use and serum uric acid levels in a nationally representative sample of women.
  97. ncbi Is polycystic ovary syndrome an exception for reproductive aging?
    Fahimeh Ramezani Tehrani
    Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University MC, 24 Parvaneh, Yaman Street, Velenjak, PO Box 19395 4763, Tehran 1985717413, Iran
    Hum Reprod 25:1775-81. 2010
    ..We examined AMH levels in PCOS and normo-ovulatory women in a population-based cohort over a period of 10 years and used this information to estimate their menopausal age...
  98. pmc Breast cancer risk in relation to the interval between menopause and starting hormone therapy
    Valerie Beral
    University of Oxford, Oxford, OX3 7LF, UK
    J Natl Cancer Inst 103:296-305. 2011
    ..We investigated whether the timing of these therapies affected breast cancer incidence...
  99. pmc Oophorectomy, menopause, estrogen treatment, and cognitive aging: clinical evidence for a window of opportunity
    Walter A Rocca
    Division of Epidemiology, Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, MN, USA
    Brain Res 1379:188-98. 2011
    ..have beneficial, neutral, or detrimental effects on the brain depending on age at the time of treatment, type of menopause (natural versus medically or surgically induced), or stage of menopause...
  100. ncbi Physical and mental health: changes during menopause transition
    Gita D Mishra
    Research Centre for Gender and Health, University of Newcastle, Australia
    Qual Life Res 12:405-12. 2003
    ..To measure changes in physical and mental health in six groups of women defined by menopausal status or use of hormone replacement therapy (HRT)...
  101. ncbi Reproductive hormones in the early menopausal transition: relationship to ethnicity, body size, and menopausal status
    John F Randolph
    Clinical Centers University of Michigan, Ann Arbor, Michigan 48109, USA
    J Clin Endocrinol Metab 88:1516-22. 2003
    ..All hormone concentrations were significantly correlated with body mass index. We conclude that serum sex steroid, FSH, and SHBG levels vary by ethnicity, but are highly confounded by ethnic disparities in body size...

Research Grants77

  1. Hypothalamic Orexin Role in Menopause-Associated Hot Flashes and Mood/Sleep Disru
    PHILIP LEE JOHNSON; Fiscal Year: 2013
    ..that estrogens suppress orexin activity and that ina recent clinical study dramatic loss of estrogen during menopause leads to a 300% increase in central levels of orexin, which was reversed with estrogen replacement...
  2. Plant-Derived Estrogens and Cell Proliferation
    Emma Shtivelman; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Menopause is associated with about a 10-15 pound weight gain and a redistribution of fat to the abdomen...
  3. Inhibition of bone formation by Prx1
    Mark S Nanes; Fiscal Year: 2013
    ..bone formation, healing, and restoration of normal bone in inflammatory bone disorders, including RA, aging, and menopause. PUBLIC HEALTH RELEVANCE: Project narrative More than 4 billion healthcare dollars are spent in the U.S...
  4. Epistasis in Steroidogenic Genes in the Prediction of Alzheimer's Disease
    CRAIG STEPHEN ATWOOD; Fiscal Year: 2013
    ..The above data indicate that the decline in circulating physiological sex steroids at menopause and during andropause would greatly impact brain functioning, and that those individuals with a higher synthetic ..
  5. Effects of brain-selective estradiol on gene expression and female sex behavior
    Kim Wallen; Fiscal Year: 2013
    ..combination with progestins or androgens are available to treat these conditions, including natural or surgical menopause. However, many women cannot or do not want to take estrogens because of their potential side effects, the most ..
  6. Interacting Impact of Adrenal and Ovarian Aging on the CNS
    Henryk F Urbanski; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): A characteristic feature of the menopause is a marked attenuation in the production and release of ovarian steroids, such as estradiol and progesterone...
  7. Vascular Surgery - Estrogen and the Injury Response
    Richard H Karas; Fiscal Year: 2012
    ..initiation of estrogen therapy, with a protective effect seen when women receive estrogen during or soon after menopause, rather than much later...
  8. Optic Nerve Aging and Glaucoma
    Thasarat Vajaranant; Fiscal Year: 2013
    ..This work will guide further research in early glaucoma screening and treatment of women with early natural menopause (approximately 6% of women) and early bilateral oophorectomy (37% of women who undergo bilateral oophorectomy)...
  9. Experimental engineering of ovarian grafting to promote angiogenesis for fertilit
    GLENN LEWIS SCHATTMAN; Fiscal Year: 2010
    ..Women have had fewer options for avoiding iatrogenic infertility and menopause compared with men, and prepubertal girls have virtually none...
  10. Humoral factors in gender differences in blood pressure control
    Jane F Reckelhoff; Fiscal Year: 2013
    ..abnormality, and increases risk for cardiovascular disease during the reproductive years as well as after menopause. The main symptom of PCOS is hyperandrogenemia, but is also characterized by hypertension, ovarian dysfunction, ..
  11. Estrogen, Aging and Vascular Inflammation
    Anne A Knowlton; Fiscal Year: 2013
    ..Given their properties, EETs have the potential to be protective post-menopause. Soluble epoxide hydrolase (sEH) converts EETs to dihydroxy-eicosatrienoic acids (DHETs), which are thought to ..
  12. STRAW+10: Addressing the Unfinished Agenda of Staging Reproductive Aging - RESUBM
    Sioban D Harlow; Fiscal Year: 2011
    ..ovarian syndrome and chronic diseases such as HIV/AIDS;and to assess potential criteria for staging the post-menopause. The Day 1 public scientific sessions will present recent advances and discuss implications of new data for ..
  13. The Role of Estradiol and Sex in the Effects of Ghrelin on Meal Patterns and Fos-
    PETER BUTERA; Fiscal Year: 2009
    ..and energy balance in humans is evidenced by the fact that the incidence of obesity increases greatly after menopause (American College of Obstetricians and Gynecologists, 2005)...
  14. A Novel Target for the Treatment of Endometriosis
    Paul D Crowe; Fiscal Year: 2011
    ..S. The disease ordinarily regresses after menopause and is highly dependent on estrogen...
  15. Interaction of Estrogen and AMPK in the Hypothalamus
    Jessica Healy; Fiscal Year: 2012
    ..In women, decreases in estradiol occur during menopause and may lead to hyperphagia and obesity. Estradiol is anorexigenic in rodents and humans...
  16. Sex chromosome aneuploidies in autoimmune disease
    R Hal Scofield; Fiscal Year: 2013
    ..The sex bias of the disease is present in patients with onset before puberty as well as at older ages after menopause. Sex hormones are abnormal in both men and women with established SLE, but at the diagnosis of SLE, prior to ..
  17. Endothelial SK3 Channel Modulation of EDHF is Estrogen Regulated
    Mike T Lin; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Physiological changes including menopause and ovariectomy induce irreversible changes in the cardiovascular system that frequently result in diminished endothelium-dependent regulation of vascular ..
  18. BDNF-Estrogen Interactions with Perimenopausal Mood and Cognition
    Elizabeth M Waters; Fiscal Year: 2012
    ..Depression rates rise sharply in women during perimenopause, which is the 7-10 year period before menopause characterized by declining estrogen levels and gradual acyclicity...
  19. Epigenetics of the Aging Astrocyte: Implications for Stroke
    Farida Sohrabji; Fiscal Year: 2013
    ..stroke with consequent functional disability is increased with age, and in women this risk is elevated after the menopause. Paradoxically, hormone therapy at menopause increases the risk for stroke...
  20. Mechanisms of vascular-specific gene regulation by estrogen
    Gavin R Schnitzler; Fiscal Year: 2013
    ..dramatically lower incidence of heart disease than age-matched men, but this difference is largely erased after menopause. Further investigation has indicated that this is because estrogen has many important functions in normal ..
  21. The Vaginal Microbiome: Disease, Genetics and the Environment
    GREGORY ALLEN BUCK; Fiscal Year: 2012
    ..There are physiologic alterations in host condition (e.g., menopause and pregnancy), which are beginning to be investigated as potential selective conditions for change in the "..
  22. Depression, Estrogen Replacement, and Cardiovascular Health in the Perimenopause
    David R Rubinow; Fiscal Year: 2013
    ..S. due to the greater burden of cardiovascular risk after menopause. Depression increases risk for CVD by two-fold...
  23. Impact of Estrogens and Menopause on Interacting Monoamine Neurotransmitters in t
    Jeffrey K Yao; Fiscal Year: 2013
    ..Using animal models of both surgical and natural menopause, we will apply this technology to evaluate the effects of 'menopause'and treatment with selective ..
  24. Endothelial Aromatase in Sex-Specific Cerebrovascular Dysfunction After Ischemia
    KRISTEN LEANNE ZULOAGA; Fiscal Year: 2012 not account for all of the protective effects seen in females since female protection persists even after menopause when ovarian estrogen is lost...
  25. Variations in Hormones During Menopause: Effects on Cognitive and Brain Aging
    Heather A Bimonte-Nelson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): In this renewal, we hypothesize that type of menopause and associated hormone changes relate to cognitive responsiveness to hormone therapy (HT)...
  26. Vascular and Neural Mechanisms of Serotonin-induced Reduction in Blood Pressure
    Stephanie W Watts; Fiscal Year: 2013
    ..substrate for 5-HT synthesis, 5-hydroxytryptophan (5-HTP), is taken as an aide for sleep, mood disorders, menopause and many other conditions and causes a fall in blood pressure...
  27. 5-HT transporter function: Interaction of antidepressants and hormones
    Alan Frazer; Fiscal Year: 2013
    ..frequently in women than in men, is associated with hormonal fluctuations (monthly, pregnancy, postpartum, and menopause)...
    Pamela L Mellon; Fiscal Year: 2011
    ..It controls puberty, the menstrual cycle, fertility, menopause, and when disregulated, causes infertility...
    Teresa A Milner; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): After menopause, hypertension and cardiovascular risk increases in women...
  30. Estrogen and hippocampal plasticity
    LORI LYNN MCMAHON; Fiscal Year: 2012
    ..Because all women undergo menopause and spend nearly 1/3 of their life in this state, intensive research effort must be dedicated to obtaining new ..
  31. Intestinal satiation in Roux-en-Y gastric bypass rats: brain mechanisms and sex d
    Thomas Alexander Lutz; Fiscal Year: 2013
    ..females, the latter especially relevant to understanding and treating the increase in adiposity associated with menopause. Three Specific Aims are proposed: (1) Determine whether the satiating actions of intra-jejunal infusions of ..
    Darlene A Dartt; Fiscal Year: 2012
    ..The causes are varied and include aging, refractive surgery, menopause, autoimmune disease, and trauma causing damage to the ocular surface resulting in pain, inflammation, and ..
  33. Gender Specific Complications of Diabetic Autonomic Neuropathy: A New Mouse Model
    JONAS BERNARD GALPER; Fiscal Year: 2010
    ..response of the heart was increased in young women compared with men;this difference was attenuated after menopause, but maintained in women on hormone replacement therapy (HRT)...
  34. Control of Nociception in the Spinal Cord
    Sukhbir S Mokha; Fiscal Year: 2013
    ..pain, particularly in women at different phases of their life (pre-puberty, reproductive years, pregnancy, and menopause) and aging men...
  35. The conditional GPR30 knockout mouse: a model of female-specific cardiac aging
    Leanne Groban; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The prevalence of diastolic dysfunction sharply increases in women after menopause and may lead to heart failure, for which there are no proven treatments...
  36. Vaginal microbiota, immune responses and vulvovaginal symptoms during menopause
    Rebecca M Brotman; Fiscal Year: 2013
    ..As women approach menopause, decreased estrogen levels are accompanied by changes in the vagina including decreased glycogen accumulation in ..
    John J Eppig; Fiscal Year: 2012
    ..female infertility are diverse, poor development of oocytes and follicles, ovulatory failure, and premature menopause are prominent among them...
  38. Characterization of Estrogen Sensitive Hypothalamic Glucose Sensing Neurons
    AMMY MARIE SANTIAGO; Fiscal Year: 2013
    ..Thus diminished estrogen levels following menopause may enhance responsiveness of GSNs to glucose decreases...
  39. Ovarian hormone suppression and regulation of adipogenesis in women
    Wendy M Kohrt; Fiscal Year: 2012
    ..The shift toward central adiposity after menopause likely contributes to increased risk for the metabolic syndrome and associated chronic diseases (i.e...
  40. Estrogen Effects on Vascular Inflammation are Age and Hormone-Status Dependent
    Fadi Hage; Fiscal Year: 2013
    ..attributed, at least in part, to the protective effects of ovarian hormones, particularly estrogens (E2), before menopause. Studies of the vascular effects of E2 have yielded paradoxical findings: observational and animal studies ..
  41. The role of neurokinin B in the generation of menopausal flushes
    Naomi E Rance; Fiscal Year: 2012
    One of the most prominent symptoms of menopause is the hot flush, a disorder of central hypothalamic thermoregulation...
  42. Short-term estradiol use in middle-age: implications for female cognitive aging
    Jill M Daniel; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Estrogen administration begun during a critical window near menopause is hypothesized to prevent or delay age-associated cognitive decline...
  43. ERalpha and the metabolic syndrome
    Andrea L Hevener; Fiscal Year: 2013
    ..ER1 action due to genetic inactivating mutations and reductions in ER1 levels in the context of obesity and menopause are associated with features of the metabolic syndrome (MS)...
  44. Melatonin in Menopausal Depression
    Barbara L Parry; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Now a clearly identified phenomenon, a major depressive episode at menopause can cause extensive morbidity and mortality...
  45. Protease regulation of ovarian recrudescence
    KELLY ANSLEY YOUNG; Fiscal Year: 2013
    ..critical clinical questions of how to shut down (contraception) and restart (assisted reproduction, premature menopause) ovarian activity with non-hormonal mechanisms...
  46. HPV &Cervix Neoplasia in a Large, Long Term HIV + Cohort
    Howard D Strickler; Fiscal Year: 2013
    ..Many are now middle-aged. In particular, a large number of HIV+ women have undergone menopause. Menopause has been associated with diminished immune response, as well as cervicovaginal atrophy (weakening the ..
  47. Use of a Fragile X premutation knock-in mouse to study FXPOI
    Joshua Johnson; Fiscal Year: 2013
    ..5% of idiopathic cases. Even without a diagnosis of FXPOI, the average age at menopause of all women with the premutation is ~5 yrs earlier than their siblings without the PM...
  48. A female-specific neuroendocrine center controlling energy expenditure
    STEPHANIE CORREA; Fiscal Year: 2013
    ..Rationale: Weight gain in middle-aged women often is associated with declining estrogen at the onset of menopause. Hormone replacement therapy (HRT) can curb postmenopausal weight gain but can also increase the risk of stroke ..
  49. Derivation of Mature Oocytes from Human Primordial Follicles
    AARON JW HSUEH; Fiscal Year: 2010
    ..stay dormant at the primordial stage for decades in women and the depletion of this dormant pool leads to menopause. Due to genetic and environmental influences, some women suffer from premature ovarian failure/insufficiency ..
  50. Study of Women's Health Across the Nation V: Endocrinology/CLASS Laboratory
    Daniel S McConnell; Fiscal Year: 2013
    ..the menopausal transition by accurately assaying reproductive ligands is central to understanding the impact of menopause on women's health from midlife through old age...
    Thomas C Foster; Fiscal Year: 2010
    ..of E2 treatment is greatly reduced or nonexistent if therapy is set in motion several years after the onset of menopause. The effectiveness of E2 treatment, limited to middle-age, suggest that there is a temporally limited ..
  52. RCT of GnRH-a for ovarian protection during CYC therapy for rheumatic disease
    WILLIAM J MC CUNE; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Premature ovarian failure, or early menopause, is a devastating side effect of some chemotherapies used for the treatment of autoimmune or rheumatic ..
  53. Reducing HIV Risk in Adult Women with Intellectual Disabilities
    JENNIFER J WELLS; Fiscal Year: 2012
    ..based on input from Phase I professional interviews that addresses sex and sexuality, birth control, pregnancy, menopause, and HIV/AIDS, 2) using content developed in Phase I, we will revise our prototype using high-definition (HD) ..
    Victoria L Holt; Fiscal Year: 2012
    ..We further hypothesize that given the dynamic cyclic changes in endometrial tissue, the years from puberty to menopause are a critical period of susceptibility for exposure to BPA in relation to this disease...
  55. Sex, sex steroids and dry eye syndromes
    David A Sullivan; Fiscal Year: 2013
    ..dry eye is typically caused by meibomian gland dysfunction and may be a major cause of dry eye during menopause, use of estrogen replacement therapy and aging...
  56. Gene-Environment Interactions in Glaucoma
    LOUIS ROBERT PASQUALE; Fiscal Year: 2013
    ..Furthermore, female reproductive attributes, as assessed by age at menopause and postmenopausal hormone use, may also play a role in POAG...
    Jon Kar Zubieta; Fiscal Year: 2012 times when estrogen levels are low or falling, such as puberty, following childbirth and in the transition to menopause, depression rates increase. These findings suggest that estrogen affects mood...
  58. Self-Management, Biobehavioral and Informatics Core
    Nancy E Reame; Fiscal Year: 2011
    ..of biobehavioral approaches to key phenomena of interest to nursing such as dyspnea, heart failure, pain, menopause, adherence, and glycemic control...
  59. Uterine-specific genetic modification and lymphangioleiomyomatosis
    JOSE M TEIXEIRA; Fiscal Year: 2012 unknown but is thought to involve hormonal regulation because it usually presents between menarche and menopause. Additionally, LAM is often found in patients with mutations in tuberous sclerosis complex (TSC), suggesting ..
  60. Gonadotropins in a female model of age-induced hypertension
    KATHRYN L SANDBERG; Fiscal Year: 2012
    ..The clinical significance of this research is the insight it will provide into the mechanisms underlying the marked rise in the prevalence of hypertension in women as they age and after their transition into menopause.
  61. Modifying Lifestyle in Prehypertensive Older Rural Women
    CAROL HALL PULLEN; Fiscal Year: 2010
    ..The incidence of HTN in women increases markedly after menopause, equaling or exceeding that in men...
  62. MSI-FLASH: An Exercise Intervention for Women with Menopausal Symptoms
    Barbara Sternfeld; Fiscal Year: 2012 Sweats and Hot Flashes), will compare the efficacy of two different doses of exercise against usual care (menopause education) for alleviating vasomotor symptoms...
  63. Restoration of Estradiol Effects on Learning by Cholinergic Enhancement
    Robert Gibbs; Fiscal Year: 2009
    ..hypothesize that the critical period for eliciting positive effects of estradiol on cognitive performance post menopause is defined by the functionality of basal forebrain cholinergic projections (i.e...
  64. The Vaginal Microbiome: Disease, Genetics and the Environment
    Gregory Buck; Fiscal Year: 2009
    ..There are physiologic alterations in host condition (e.g., menopause and pregnancy), which are beginning to be investigated as potential selective conditions for change in the "..
  65. Prevention of Menopause-Related Ovarian Epithelial Cancer
    Elizabeth R Smith; Fiscal Year: 2010
    ..having disseminated to the peritoneal lining of the abdomen, and most (about 85%) are diagnosed in women post-menopause. If detected while still localized in the ovary, the success rate of treatment is high, with a 5-year survival ..
  66. A Secular Change in Menstrual Characteristicis of Adult and Midlife Women?
    Sioban D Harlow; Fiscal Year: 2010 applicant): Secular declines in age at menarche have been well documented and a secular increase in age at menopause has been suggested by some studies...
  67. Botanicals from Central America for Menopause
    Gail Mahady; Fiscal Year: 2005
    b>Menopause is a universal female experience, and is defined as cessation of menstruation for at least 12 months during the midlife period...
  68. Interaction of Estrogen and Serotonin in Modulating Brain Activation in Menopause
    C Neill Epperson; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): During the menopause transition, many women report a worsening of their mood and a subjective impairment in memory...
    Terry Young; Fiscal Year: 2006
    ..of this ongoing longitudinal study of midlife aging in women are to accurately quantify the associations of menopause with the development and progression of sleep apnea and diminished sleep quality and to identify factors that ..
  70. Estrogen Effects on Atrophic Skeletal Muscle
    Marybeth Brown; Fiscal Year: 2009
    ..or rehabilitation care each year, approximately 1/2 of them are "estrogen-deficient" due to natural menopause, surgical menopause, and normal hormonal rhythms disrupted by illness or trauma...
    James Goodrich; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Menopause in women is an understudied normal aspect of the aging process that is associated with a loss of estrogen production and increased risk of cardiovascular disease and other ..
    Yewoubdar Beyene; Fiscal Year: 1992
    Cross-cultural studies of age and menopause related skeletal changes are absent and detailed research addressing this issue will contribute new insight into the study of menopause, aging, and osteoporosis...
  73. Cognitive Behavioral Therapy for Insomnia and Nocturnal Hot Flashes in Menopause
    Sara Nowakowski; Fiscal Year: 2012
    ..b>Menopause-associated insomnia is associated with adverse consequences including reduced quality of life, increased health ..
    Patricia Murphy; Fiscal Year: 2006
    ..DESCRIPTION (provided by applicant): Sleep complaints increase dramatically among women experiencing the menopause transition, and these complaints do not cease post-menopause...
  75. Increased Cardiovacular Risk and Early Natural Menopause in a Biracial Cohort
    Melissa Fair Wellons; Fiscal Year: 2012 that atherosclerosis of the ovarian vasculature during young adulthood may be a primary determinant of early menopause (natural menopause at an age # 46)...
  76. Oxidative stress drives ovarian aging: modification by genetics and environment
    Ulrike Luderer; Fiscal Year: 2009
    ..The decline and eventual cessation of ovarian function, termed menopause, is associated with other adverse consequences, such as increased risks of cardiovascular disease and ..
    Andrea Suhner; Fiscal Year: 2001
    Up to half of all women going through menopause report significant sleep disturbance. A number of factors contribute to these sleep problems, with hormonal imbalance and hot flashes being the most important...