first pregnancy trimester

Summary

Summary: The beginning third of a human PREGNANCY, from the first day of the last normal menstrual period (MENSTRUATION) through the completion of 14 weeks (98 days) of gestation.

Top Publications

  1. pmc Onset of maternal arterial blood flow and placental oxidative stress. A possible factor in human early pregnancy failure
    E Jauniaux
    Academic Department of Obstetrics and Gynaecology, University College London, London, United Kingdom
    Am J Pathol 157:2111-22. 2000
  2. ncbi Tumor necrosis factor-alpha inhibits trophoblast migration through elevation of plasminogen activator inhibitor-1 in first-trimester villous explant cultures
    Sandra Bauer
    Department of Obstetrics and Gynecology, University of Vienna, A 1090 Vienna, Austria
    J Clin Endocrinol Metab 89:812-22. 2004
  3. pmc Leukemia inhibitory factor promotes human first trimester extravillous trophoblast adhesion to extracellular matrix and secretion of tissue inhibitor of metalloproteinases-1 and -2
    Alejandro Tapia
    Prince Henry s Institute of Medical Research, PO Box, 5152 Clayton, VIC 3168, Australia
    Hum Reprod 23:1724-32. 2008
  4. ncbi Uterine glands provide histiotrophic nutrition for the human fetus during the first trimester of pregnancy
    Graham J Burton
    Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, United Kingdom
    J Clin Endocrinol Metab 87:2954-9. 2002
  5. ncbi Maternal thyroid hormones early in pregnancy and fetal brain development
    Gabriella Morreale de Escobar
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas CSIC y Universidad Autonoma de Madrid UAM, Arturo Duperier, 4, 28029 Madrid, Spain
    Best Pract Res Clin Endocrinol Metab 18:225-48. 2004
  6. ncbi Dynamic expression of matrix metalloproteinases (MMP-2, -9 and -14) and the tissue inhibitors of MMPs (TIMP-1, -2 and -3) at the implantation site during tubal pregnancy
    S X Bai
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China
    Reproduction 129:103-13. 2005
  7. ncbi Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts
    Martin Bilban
    Department of Cell Biology, The Scripps Research Institute, North Torrey Pines Road, La Jolla, CA 92037, USA
    J Cell Sci 117:1319-28. 2004
  8. pmc Expression and importance of matrix metalloproteinase 2 and 9 (MMP-2 and -9) in human trophoblast invasion
    Elsebeth Staun-Ram
    Laboratory for Research in Reproductive Sciences, Department of Obstetrics and Gynecology, Ha Emek Medical Center, 18101, Afula, Israel
    Reprod Biol Endocrinol 2:59. 2004
  9. ncbi Expression of the fusogenic HERV-FRD Env glycoprotein (syncytin 2) in human placenta is restricted to villous cytotrophoblastic cells
    A Malassine
    INSERM, U767, 4 avenue de l Observatoire, 75006 Paris, France Université Paris Descartes, Faculte des Sciences Pharmaceutiques et Biologiques, 4 avenue de l Observatoire, 75006 Paris, France
    Placenta 28:185-91. 2007
  10. ncbi The contribution of placental oxidative stress to early pregnancy failure
    Joanne Hempstock
    Department of Anatomy, Cambridge University, UK
    Hum Pathol 34:1265-75. 2003

Detail Information

Publications256 found, 100 shown here

  1. pmc Onset of maternal arterial blood flow and placental oxidative stress. A possible factor in human early pregnancy failure
    E Jauniaux
    Academic Department of Obstetrics and Gynaecology, University College London, London, United Kingdom
    Am J Pathol 157:2111-22. 2000
    ..We speculate that this may serve a physiological role in stimulating normal placental differentiation, but may also be a factor in the pathogenesis of pre-eclampsia and early pregnancy failure if antioxidant defenses are depleted...
  2. ncbi Tumor necrosis factor-alpha inhibits trophoblast migration through elevation of plasminogen activator inhibitor-1 in first-trimester villous explant cultures
    Sandra Bauer
    Department of Obstetrics and Gynecology, University of Vienna, A 1090 Vienna, Austria
    J Clin Endocrinol Metab 89:812-22. 2004
    ..Induction of PAI-1 by TNF alpha could be related to restricted trophoblast invasion in preeclampsia...
  3. pmc Leukemia inhibitory factor promotes human first trimester extravillous trophoblast adhesion to extracellular matrix and secretion of tissue inhibitor of metalloproteinases-1 and -2
    Alejandro Tapia
    Prince Henry s Institute of Medical Research, PO Box, 5152 Clayton, VIC 3168, Australia
    Hum Reprod 23:1724-32. 2008
    ..It has been suggested that LIF may play a role in human first trimester extravillous trophoblast (EVT) invasion. The aim of the present study was to establish whether LIF induces changes in EVT function related to invasiveness...
  4. ncbi Uterine glands provide histiotrophic nutrition for the human fetus during the first trimester of pregnancy
    Graham J Burton
    Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, United Kingdom
    J Clin Endocrinol Metab 87:2954-9. 2002
    ..Our findings demonstrate that the uterine glands are an important source of nutrients during organogenesis, when metabolism is essentially anaerobic...
  5. ncbi Maternal thyroid hormones early in pregnancy and fetal brain development
    Gabriella Morreale de Escobar
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas CSIC y Universidad Autonoma de Madrid UAM, Arturo Duperier, 4, 28029 Madrid, Spain
    Best Pract Res Clin Endocrinol Metab 18:225-48. 2004
    ..Detection of an inappropiate first trimester FT4 surge that may not result in increased TSH, may be crucial for the prevention of learning disabilities in a significant number of unborn children...
  6. ncbi Dynamic expression of matrix metalloproteinases (MMP-2, -9 and -14) and the tissue inhibitors of MMPs (TIMP-1, -2 and -3) at the implantation site during tubal pregnancy
    S X Bai
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China
    Reproduction 129:103-13. 2005
    ..Meanwhile, the study provides a better understanding of the mechanisms involved in cellular events during human pregnancy, especially at the initiation stage of implantation...
  7. ncbi Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts
    Martin Bilban
    Department of Cell Biology, The Scripps Research Institute, North Torrey Pines Road, La Jolla, CA 92037, USA
    J Cell Sci 117:1319-28. 2004
    ..These results identified Kp-10 as a novel paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself...
  8. pmc Expression and importance of matrix metalloproteinase 2 and 9 (MMP-2 and -9) in human trophoblast invasion
    Elsebeth Staun-Ram
    Laboratory for Research in Reproductive Sciences, Department of Obstetrics and Gynecology, Ha Emek Medical Center, 18101, Afula, Israel
    Reprod Biol Endocrinol 2:59. 2004
    ....
  9. ncbi Expression of the fusogenic HERV-FRD Env glycoprotein (syncytin 2) in human placenta is restricted to villous cytotrophoblastic cells
    A Malassine
    INSERM, U767, 4 avenue de l Observatoire, 75006 Paris, France Université Paris Descartes, Faculte des Sciences Pharmaceutiques et Biologiques, 4 avenue de l Observatoire, 75006 Paris, France
    Placenta 28:185-91. 2007
    ..In vitro detection of HERV-FRD transcripts was restricted to villous trophoblastic cells and decreased significantly with time in culture. These results suggest that syncytin 2 might play a role in human trophoblastic cell fusion...
  10. ncbi The contribution of placental oxidative stress to early pregnancy failure
    Joanne Hempstock
    Department of Anatomy, Cambridge University, UK
    Hum Pathol 34:1265-75. 2003
    ....
  11. ncbi The secretion and effect of inhibin A, activin A and follistatin on first-trimester trophoblasts in vitro
    C Bearfield
    Department of Obstetrics and Gynaecology, RFUC Medical School, 86 96 Chenies Mews, London WC1E 6HX, UK
    Eur J Endocrinol 152:909-16. 2005
    ..The objectives of this study were to investigate the effect of activin A and follistatin on first-trimester cytotrophoblast invasion in culture and to study the secretion of inhibin A, activin A and follistatin by these cells in vitro...
  12. ncbi Evaluation of respiratory gases and acid-base gradients in human fetal fluids and uteroplacental tissue between 7 and 16 weeks' gestation
    E Jauniaux
    Department of Obstetrics and Gynaecology, Royal Free and University College London Medical School, United Kingdom
    Am J Obstet Gynecol 184:998-1003. 2001
    ..Our purpose was to evaluate the changes in intrauterine gases and acid-base gradients inside the human fetoplacental unit at 7 to 16 weeks' gestation...
  13. ncbi Polyol concentrations in the fluid compartments of the human conceptus during the first trimester of pregnancy: maintenance of redox potential in a low oxygen environment
    Eric Jauniaux
    Academic Department of Obstetrics and Gynecology, Royal Free and University College London Medical School, London WC1E 6HX, UK
    J Clin Endocrinol Metab 90:1171-5. 2005
    ..Polyols may also play important physiological roles in development of the human conceptus, possibly drawing water and solutes across the placenta and expanding the gestational sac...
  14. ncbi First trimester adipocytokine concentrations and risk of developing gestational diabetes later in pregnancy
    Kristine Y Lain
    Department of Obstetrics and Gynaecology, University of Kentucky, Lexington, KY 40536 0293, USA
    Clin Endocrinol (Oxf) 69:407-11. 2008
    ..Adipocytokines are important regulators of insulin resistance. The aim of this study was to compare maternal adipocytokines in early pregnancy among women diagnosed with and without gestational diabetes (GDM) months later...
  15. ncbi Immunohistochemistry of matrix metalloproteinases (MMP), their substrates, and their inhibitors (TIMP) during trophoblast invasion in the human placenta
    B Huppertz
    Department of Anatomy, RWTH Aachen, Wendlingweg 2, D 52057 Aachen, Germany
    Cell Tissue Res 291:133-48. 1998
    ..Within the extracellular matrix, immunolocalization of matrix metalloproteinases as well as their inhibitors showed a specific relation to certain extracellular matrix molecules...
  16. ncbi Nutrition of the human fetus during the first trimester--a review
    G J Burton
    Department of Anatomy, University of Cambridge, UK
    Placenta 22:S70-7. 2001
    ..Once this is complete, and fetal oxygen requirements rise, there is a transition to haemotrophic nutrition at the start of the second trimester, when the maternal placental circulation is fully established...
  17. ncbi Dendritic cells in the human decidua
    Lucy Gardner
    Research Group in Human Reproductive Immunobiology, Department of Pathology, University of Cambridge, Cambridge CB2 1QP, United Kingdom
    Biol Reprod 69:1438-46. 2003
    ..They were also visible in endothelial-lined spaces. This is the first study to identify and describe the phenotype and distribution of human decidual DCs...
  18. ncbi First and second trimester antenatal screening for Down's syndrome: the results of the Serum, Urine and Ultrasound Screening Study (SURUSS)
    N J Wald
    Department of Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, Bart s and The London School of Medicine and Dentistry, London EC1M 6BQ, UK
    J Med Screen 10:56-104. 2003
  19. ncbi First-trimester combined screening for Down syndrome and other fetal anomalies
    Peter O'Leary
    Department of Health Western Australia, Perth, Australia
    Obstet Gynecol 107:869-76. 2006
    ..This study assessed fetal outcomes for pregnancies identified at increased risk for Down syndrome by first-trimester combined ultrasound examination and maternal serum biochemistry screening...
  20. ncbi A serum proteomics approach to the diagnosis of ectopic pregnancy
    G L Gerton
    Center for Research on Reproduction and Women s Health, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 6080, USA
    Ann N Y Acad Sci 1022:306-16. 2004
    ....
  21. ncbi Maternal vitamin D deficiency increases the risk of preeclampsia
    Lisa M Bodnar
    Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, A742 Crabtree Hall, 130 DeSoto Street, Pittsburgh, Pennsylvania, 15261, USA
    J Clin Endocrinol Metab 92:3517-22. 2007
    ..Vitamin D has direct influence on molecular pathways proposed to be important in the pathogenesis of preeclampsia, yet the vitamin D-preeclampsia relation has not been studied...
  22. ncbi Absence of nasal bone in fetuses with trisomy 21 at 11-14 weeks of gestation: an observational study
    S Cicero
    Harris Birthright Research Centre for Fetal Medicine, King's College Hospital Medical School, Denmark Hill, SE5 8RX, London, UK
    Lancet 358:1665-7. 2001
    ..INTERPRETATION: In screening for trisomy 21, examination of the fetal nasal bone could result in major reduction in the need for invasive testing and a substantial increase in sensitivity...
  23. ncbi Embryo toxicity and teratogenicity of formaldehyde
    J D Thrasher
    Sam 1 Trust, Alto, New Mexico, USA
    Arch Environ Health 56:300-11. 2001
    ..Finally, screening for teratogenic events should also include exposure of females before mating or shortly following mating. Such a regimen is fruitful inasmuch as environmental agents cause adverse effec..
  24. ncbi GLUT12 expression in human placenta in first trimester and term
    N M Gude
    Department of Perinatal Medicine, Royal Women s Hospital, Carlton, Victoria, Australia
    Placenta 24:566-70. 2003
    ..These results suggest that there is a dynamic spatial and temporal expression pattern for the novel glucose transporter GLUT12 in human placenta...
  25. ncbi Normal nonmetastatic human trophoblast cells share in vitro invasive properties of malignant cells
    S Yagel
    Department of Anatomy, University of Western Ontario, London, Canada
    J Cell Physiol 136:455-62. 1988
    ....
  26. ncbi Expression of angiogenic growth factors by uterine natural killer cells during early pregnancy
    Gendie E Lash
    School of Surgical and Reproductive Sciences, 3rd Floor, William Leech Building, University of Newcastle upon Tyne, Newcastle upon Tyne, NE2 4HH, UK
    J Leukoc Biol 80:572-80. 2006
    ..uNK cells appear to be a prominent source of Ang1, Ang2, TGF-beta1, and VEGF-C within the placental bed...
  27. pmc Unique appearance of proliferating antigen-presenting cells expressing DC-SIGN (CD209) in the decidua of early human pregnancy
    Ulrike Kammerer
    Department of Obstetrics and Gynecology, the University Medical School Würzburg, Wurzburg, Germany
    Am J Pathol 162:887-96. 2003
    ....
  28. ncbi Expression and activity of matrix metalloproteinase 2 and 9 in human trophoblasts
    K Isaka
    Department of Obstetrics and Gynecology, Tokyo Medical University, 6 7 1 Nishi shinjuku, Japan
    Placenta 24:53-64. 2003
    ..These suggests that the invasive ability of trophoblasts may be regulated by the enzyme activity of gelatinases, especially MMP-2...
  29. ncbi Effects of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 on cytokine production by human decidual cells
    Katie N Evans
    Division of Medical Sciences, Institute of Biomedical Research, The University of Birmingham, Birmingham, B15 2TT, United Kingdom
    Biol Reprod 75:816-22. 2006
    ....
  30. pmc Association between outcome of pregnancy and glycaemic control in early pregnancy in type 1 diabetes: population based study
    Rosemary Temple
    Elsie Bertram Diabetes Centre, Norfolk and Norwich University Hospital NHS Trust, Norwich NR4 7UY, UK
    BMJ 325:1275-6. 2002
  31. ncbi First-trimester trophoblast cell model gene response to hypoxia
    Nikki Koklanaris
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, New York University School of Medicine, New York, NY, USA
    Am J Obstet Gynecol 194:687-93. 2006
    ..We used microarray technology in a trophoblast cell line to identify hypoxia-responsive genes that may impact placentation...
  32. ncbi First- and second-trimester evaluation of risk for Down syndrome
    Robert H Ball
    Department of Obstetrics, Gynecology, and Reproductive Sciences, UCSF, San Francisco, CA 94143 0132, USA
    Obstet Gynecol 110:10-7. 2007
    ..To investigate the differences in costs and outcomes of Down syndrome screening using data from the First and Second Trimester Evaluation of Risk (FASTER) Trial...
  33. ncbi Chorionic villus sampling compared with amniocentesis and the difference in the rate of pregnancy loss
    Aaron B Caughey
    Division of Perinatal Medicine and Genetics, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, California, USA
    Obstet Gynecol 108:612-6. 2006
    ..To compare loss rates following amniocentesis and chorionic villus sampling (CVS) over time...
  34. ncbi Insulin-like growth factor I and II regulate the life cycle of trophoblast in the developing human placenta
    Karen Forbes
    Maternal and Fetal Health Research Group, University of Manchester, St Mary s Hospital, Manchester, UK
    Am J Physiol Cell Physiol 294:C1313-22. 2008
    ..However, IGFs can exert an exogenous regulatory influence on placental growth/development, suggesting that manipulation of the placental IGF axis may offer a potential therapeutic route to the correction of inadequate placental growth...
  35. ncbi Exposure to air pollution during different gestational phases contributes to risks of low birth weight
    B E Lee
    Department of Preventive Medicine, College of Medicine, Ewha Medical Research Center, Ewha Womans University, 911 1, Mok 6 Dong, Yangcheon Gu, Seoul, Korea 158 710
    Hum Reprod 18:638-43. 2003
    ..Although there have been growing concerns about the adverse effects of air pollution on birth outcomes, little is known about which specific exposure times of specific pollutants contribute to low birth weight (LBW)...
  36. ncbi Risk indicators predictive for severe hypoglycemia during the first trimester of type 1 diabetic pregnancy
    Inge M Evers
    Department of Obstetrics, Utrecht University, University Medical Center, Utrecht, The Netherlands
    Diabetes Care 25:554-9. 2002
    ....
  37. ncbi Factors affecting women's preference for type of prenatal screening test for chromosomal anomalies
    K Spencer
    Prenatal Screening Unit, Clinical Biochemistry Department, Harold Wood Hospital, Romford, Essex, UK
    Ultrasound Obstet Gynecol 24:735-9. 2004
    ..To ascertain, by means of a questionnaire, women's preferences for four different approaches to prenatal screening for Down syndrome...
  38. ncbi Multi-centre first-trimester screening for Down syndrome in the Netherlands in routine clinical practice
    P C J I Schielen
    Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, National Institute for Public Health and the Environment RIVM, Bilthoven, The Netherlands
    Prenat Diagn 26:711-8. 2006
    ..This is the first report on the results of a first-trimester combined-test screening programme in the Netherlands in a multi-centre routine clinical setting...
  39. ncbi First-trimester or second-trimester screening, or both, for Down's syndrome
    Fergal D Malone
    Columbia University College of Physicians and Surgeons, New York, USA
    N Engl J Med 353:2001-11. 2005
    ..It is uncertain how best to screen pregnant women for the presence of fetal Down's syndrome: to perform first-trimester screening, to perform second-trimester screening, or to use strategies incorporating measurements in both trimesters...
  40. ncbi Decidual natural killer cell tuning by autologous dendritic cells
    Gordana Laskarin
    Department of Physiology and Immunology, Medical Faculty, University of Rijeka, Rijeka, Croatia
    Am J Reprod Immunol 59:433-45. 2008
    ..Dendritic cells (DC)/natural killer (NK) cells interactions in the deciduas of early human pregnancies were analyzed in vitro...
  41. ncbi Messenger RNA for membrane-type 2 matrix metalloproteinase, MT2-MMP, is expressed in human placenta of first trimester
    S F Bjørn
    The Finsen Laboratory, Rigshospitalet, Copenhagen, DK 2100, Denmark
    Placenta 21:170-6. 2000
    ..The data suggest that MT2-MMP, capable of activating MMP-2 in vitro, is involved in the invasion of extravillous cytotrophoblast, possibly related to the physiological activation of MMP-2...
  42. ncbi Hormonal regulation of glucose and system A amino acid transport in first trimester placental villous fragments
    Anette Ericsson
    Perinatal Center, Dept of Physiology and Pharmacology, Goteborg University, Box 432, 405 30 Goteborg, Sweden
    Am J Physiol Regul Integr Comp Physiol 288:R656-62. 2005
    ..In contrast to term placental villous fragments, system A activity was not regulated by insulin or leptin in first trimester but was downregulated by GH...
  43. ncbi Evaluation of the placental environment with a new in vitro model of histocultures of early and term placentae: determination of cytokine and chemokine expression profiles
    A Faye
    Biology of Retroviruses Unit, Institut Pasteur, 28 rue du Dr Roux, 75015 Paris, France
    Placenta 26:262-7. 2005
    ..These data indicate that placental histoculture is a suitable and reliable in vitro model for studying the placental environment...
  44. ncbi Effect of screening for red cell antibodies, other than anti-D, to detect hemolytic disease of the fetus and newborn: a population study in the Netherlands
    J M Koelewijn
    Sanquin Research, Amsterdam, The Netherlands
    Transfusion 48:941-52. 2008
    ..The effect of a first-trimester antibody screening program on the timely detection of HDFN caused by antibodies other than anti-D was evaluated...
  45. ncbi Human chorionic gonadotropin expression in human trophoblasts from early placenta: comparative study between villous and extravillous trophoblastic cells
    K Handschuh
    INSERM, U427, Faculte des Sciences Pharmaceutiques et Biologiques, Universite Rene Descartes, Paris 5, 75006 Paris, France
    Placenta 28:175-84. 2007
    ..Our data demonstrated that in addition to the ST, invasive EVCT also expressed and secreted high levels of hCG, suggesting a specific paracrine and/or autocrine role for hCG from EVCT origin...
  46. pmc Prokineticin 1 modulates IL-8 expression via the calcineurin/NFAT signaling pathway
    David Maldonado-Pérez
    Human Reproductive Sciences Unit, Medical Research Council, Edinburgh EH16 4TJ, UK
    Biochim Biophys Acta 1793:1315-24. 2009
    ..Our findings show that in endometrial cells PROK1 can activate the calcineurin/NFAT pathway to induce IL-8 expression and that this is negatively modulated by the induction of expression of RCAN1-4...
  47. ncbi SURUSS in perspective
    N J Wald
    Department of Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry, UK
    BJOG 111:521-31. 2004
    ..We here present the main results from SURUSS, updated to take account of recent information on nuchal translucency in Down's Syndrome pregnancies, and discuss their implications...
  48. ncbi Oxygen and placental development during the first trimester: implications for the pathophysiology of pre-eclampsia
    I Caniggia
    Samuel Lunenfeld Research Institute, Department of Obstetrics and Gynaecology, Mount Sinai Hospital, Toronto, Ontario, Canada
    Placenta 21:S25-30. 2000
    ..synthesis and degradation of extracellular matrix proteins and their receptors, and changes in the spatial distribution of extracellular matrix proteins, as well as changes in the expression of adhesion molecules (Damsky, Fitzgerald and..
  49. ncbi SNAT4 isoform of system A amino acid transporter is expressed in human placenta
    M Desforges
    Division of Human Development, St Mary s Hospital, The Medical School, University of Manchester, Manchester, United Kingdom
    Am J Physiol Cell Physiol 290:C305-12. 2006
    ..This study therefore provides the first evidence of SNAT4 mRNA and protein expression in the human placenta, both at the first trimester and at full term...
  50. ncbi Integrated ultrasound and biochemical screening for trisomy 21 using fetal nuchal translucency, absent fetal nasal bone, free beta-hCG and PAPP-A at 11 to 14 weeks
    Simona Cicero
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, Denmark Hill, London, UK
    Prenat Diagn 23:306-10. 2003
    ....
  51. ncbi The influence of ethnic origin on first trimester biochemical markers of chromosomal abnormalities
    K Spencer
    Endocrine Unit, Clinical Biochemistry Department, Harold Wood Hospital, Gubbins Lane, Romford, Essex RM3 0BE, UK
    Prenat Diagn 20:491-4. 2000
    ..The impact of ethnic origin seems to be greater than that observed with second trimester biochemical markers and larger studies are required in order to develop robust algorithms for correcting for ethnic origin in the first trimester...
  52. ncbi Comparison of first and second trimester aneuploidy risk assessment
    Uma M Reddy
    Department of Health and Human Services, Pregnancy and Perinatology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 7510, USA
    Clin Obstet Gynecol 50:442-53. 2007
    ....
  53. ncbi [Prevalence of smoking cessation during pregnancy according to trimester]
    G Grange
    Association Alliés, 20, Boulevard Malesherbes, 75008 Paris, France
    Gynecol Obstet Fertil 34:1126-30. 2006
    ..To investigate the smoking cessation period during pregnancy...
  54. ncbi Nasal bone in first-trimester screening for trisomy 21
    Simona Cicero
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, United Kingdom
    Am J Obstet Gynecol 195:109-14. 2006
    ..This study was undertaken to investigate the impact of incorporating assessment of the nasal bone into first-trimester combined screening by fetal nuchal translucency (NT) thickness and maternal serum biochemistry...
  55. ncbi Cytogenetic analyses of culture failures by comparative genomic hybridisation (CGH)-Re-evaluation of chromosome aberration rates in early spontaneous abortions
    B Fritz
    Institut für Klinische Genetik, Philipps Universitat Marburg, Germany
    Eur J Hum Genet 9:539-47. 2001
    ..Investigating abortion tissues hitherto unassessed by conventional methods, we suggest that the contribution of chromosome aberrations to first trimester pregnancy loss is nearly 70%...
  56. ncbi HbA1c in early diabetic pregnancy and pregnancy outcomes: a Danish population-based cohort study of 573 pregnancies in women with type 1 diabetes
    Gunnar L Nielsen
    Department of Clinical Epidemiology, Aalborg Hospital, Sdr Skovrej 15, DK 9000 Aalborg, Denmark
    Diabetes Care 29:2612-6. 2006
    ..To assess the association between first-trimester HbA(1c) (A1C) and the risk of adverse pregnancy outcomes in type 1 diabetic pregnancies...
  57. ncbi Practical strategies in contingent sequential screening for Down syndrome
    Peter Benn
    Department of Genetics and Developmental Biology, University of Connecticut, Health Center, Farmington, CT 06030 6140, USA
    Prenat Diagn 25:645-52. 2005
    ..To design and assess the performance of protocols for contingent sequential Down syndrome screening that can be implemented in practice...
  58. ncbi Possible interactions between leptin, gonadotrophin-releasing hormone (GnRH-I and II) and human chorionic gonadotrophin (hCG)
    D Islami
    Department of Obstetrics and Gynaecology, Clinic of Infertility and Gynaecological Endocrinology, WHO Collaborating Centre in Human Reproduction, University Hospital of Geneva, 32 Boulevard de la Cluse, 1211, Geneva, Switzerland
    Eur J Obstet Gynecol Reprod Biol 110:169-75. 2003
    ..Furthermore, we observe that leptin has a significant stimulatory effect on hCG pulsatility...
  59. ncbi Regulation of trophoblastic gelatinases by proto-oncogenes
    P Bischof
    Department of Obstetrics and Gynaecology, University of Geneva, Box 232 Addenbrooke s Hospital, Maternité, Switzerland
    Placenta 24:155-63. 2003
    ..We conclude that AP-1 is necessary but may not be sufficient for transactivation of the MMP-9 gene in human CTB...
  60. ncbi First-trimester sex hormone binding globulin and subsequent gestational diabetes mellitus
    Ravi Thadhani
    Departments of Medicine and Obstetrics and Gynecology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Obstet Gynecol 189:171-6. 2003
    ..We sought to examine the association between early pregnancy levels of sex hormone binding globulin and subsequent gestational diabetes mellitus, an association that has not been studied previously...
  61. ncbi Regulatory effects of gonadotropin-releasing hormone (GnRH) I and GnRH II on the levels of matrix metalloproteinase (MMP)-2, MMP-9, and tissue inhibitor of metalloproteinases-1 in primary cultures of human extravillous cytotrophoblasts
    Chun Shan Chou
    Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, British Columbia, Canada V6H 3V5
    J Clin Endocrinol Metab 88:4781-90. 2003
    ..Collectively, these observations suggest that GnRH I and GnRH II differentially regulate MMP-2, MMP-9, and TIMP-1 expression in human trophoblasts, possibly via distinct receptor-mediated intracellular signaling pathways...
  62. ncbi Integrated, sequential, and contingent screening for Down syndrome - local needs should drive methodology
    Philip Wyatt
    Prenat Diagn 27:186-7. 2007
  63. ncbi EMILIN1 represents a major stromal element determining human trophoblast invasion of the uterine wall
    Paola Spessotto
    Divisione di Oncologia Sperimentale 2, CRO IRCCS, 33081 Aviano, Italy
    J Cell Sci 119:4574-84. 2006
    ..Finally, membrane type I-matrix metalloproteinase (MT1-MMP) and MMP-2 were upregulated in co-cultures of trophoblast cells and stromal cells, suggesting a contributing role in the haptotactic process towards EMILIN1...
  64. ncbi Antenatal screening for Down syndrome in New Zealand: time for a national screening policy?
    Tou Choong Chang
    Department of Obstetrics and Gynaecology, University of Auckland, Auckland, New Zealand
    Aust N Z J Obstet Gynaecol 46:92-6. 2006
  65. pmc Management of miscarriage: expectant, medical, or surgical? Results of randomised controlled trial (miscarriage treatment (MIST) trial)
    J Trinder
    Southmead Hospital, Westbury on Trym, Bristol BS10 5NB
    BMJ 332:1235-40. 2006
    ..To ascertain whether a clinically important difference exists in the incidence of gynaecological infection between surgical management and expectant or medical management of miscarriage...
  66. pmc Inhibition of TGF-beta 3 restores the invasive capability of extravillous trophoblasts in preeclamptic pregnancies
    I Caniggia
    Program in Fetal Health and Development, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    J Clin Invest 103:1641-50. 1999
    ..We speculate that a failure to downregulate expression of TGF-beta 3 at around 9 weeks' gestation results in shallow trophoblast invasion and predisposes the pregnancy to preeclampsia...
  67. ncbi Comparison of the effects of GnRH-I and GnRH-II on HCG synthesis and secretion by first trimester trophoblast
    D Islami
    Department of Obstetrics and Gynaecology, Clinic of Infertility and Gynaecological Endocrinology, WHO Collaborating Centre in Human Reproduction, University Hospital of Geneva, 32 Boulevard de la Cluse, 1211 Geneva, Switzerland
    Mol Hum Reprod 7:3-9. 2001
    ..This difference could be explained by different pathways of GnRH degradation, different receptor affinities, or even by different types of placental GnRH receptor...
  68. ncbi The effect of vascular origin, oxygen, and tumour necrosis factor alpha on trophoblast invasion of maternal arteries in vitro
    Ian P Crocker
    Maternal and Fetal Health Research Centre, University of Manchester, St Mary s Hospital, Manchester, UK
    J Pathol 206:476-85. 2005
    ..Adequate vascular transformation may therefore rely on a balance between vascular receptivity, oxygen partial pressure, and exposure to inflammatory mediators...
  69. ncbi Economic modelling of antenatal screening and ultrasound scanning programmes for identification of fetal abnormalities
    K Ritchie
    NHS Quality Improvement Scotland, Glasgow, UK
    BJOG 112:866-74. 2005
    ..Within the framework of a health technology assessment and using an economic model, to determine the most clinically and cost effective policy of scanning and screening for fetal abnormalities in early pregnancy...
  70. pmc Antenatal screening for haemoglobinopathies in primary care: a whole system participatory action research project
    Paul Thomas
    Thames Valley University and Brent Teaching Primary Care Trust, London
    Br J Gen Pract 55:424-8. 2005
    ..The usual system for antenatal screening for haemoglobinopathies permits termination only late in the second trimester of pregnancy...
  71. ncbi Gestational exposure to lovastatin followed by cardiac malformation misclassified as holoprosencephaly
    Robin J Edison
    N Engl J Med 352:2759. 2005
  72. ncbi Economic evaluation of alternative management methods of first-trimester miscarriage based on results from the MIST trial
    S Petrou
    National Perinatal Epidemiology Unit, University of Oxford Old Road Campus, Headington, Oxford, UK
    BJOG 113:879-89. 2006
    ..To compare the cost-effectiveness of alternative management methods of first-trimester miscarriage...
  73. ncbi Sequential and contingent prenatal screening for Down syndrome
    Nicholas J Wald
    Wolfson Institute of Preventive Medicine, Barts and The London Queen Mary s School of Medicine and Dentistry, London EC1M 6BQ, UK
    Prenat Diagn 26:769-77. 2006
    ....
  74. ncbi The effects of oxygen concentration and gestational age on extravillous trophoblast outgrowth in a human first trimester villous explant model
    Joanna L James
    Department of Obstetrics and Gynecology, University of Auckland, Auckland, New Zealand
    Hum Reprod 21:2699-705. 2006
    ..This work aimed to quantify the effects of gestational age and oxygen concentration on extravillous trophoblast outgrowth...
  75. ncbi Aneuploidy screening in the first trimester
    Kevin Spencer
    Prenatal Screening Unit, Clinical Biochemistry Department, Harold Wood Hospital, Romford, UK
    Am J Med Genet C Semin Med Genet 145:18-32. 2007
    ....
  76. ncbi First trimester ultrasonography in screening and detection of fetal anomalies
    Jiri Sonek
    Maternal Fetal Medicine Ultrasound and Genetics, Miami Valley Hospital, Dayton, OH 45409, USA
    Am J Med Genet C Semin Med Genet 145:45-61. 2007
    ..Their appearance at this early gestational age is discussed as well. It is clear that, data obtained by first trimester ultrasound are useful in counseling expectant parents and in planning the appropriate follow-up...
  77. ncbi Comparing three screening strategies for combining first- and second-trimester Down syndrome markers
    Glenn E Palomaki
    Division of Medical Screening, Department of Pathology and Laboratory Medicine, Women and Infants Hospital, Providence, RI 02903, USA
    Obstet Gynecol 107:367-75. 2006
    ..To describe the choices and tradeoffs inherent in 3 published strategies that combine first- and second-trimester markers for Down syndrome screening...
  78. ncbi Status of p53 in first-trimester cytotrophoblastic cells
    M Cohen
    Department of Obstetrics and Gynaecology, Maternity, Laboratory of Hormonology, University of Geneva, Geneva, Switzerland
    Mol Hum Reprod 13:111-6. 2007
    ..These complexes could prolong the half-life of p53 in the cytoplasm of CTBs. By contrast, in the nuclei of CTBs, p53 seems to be present as a tetramer...
  79. ncbi Profiling chemokines, cytokines and growth factors in human early pregnancy decidua by protein array
    Sabine Engert
    Department of Obstetrics and Gynaecology, University of Wurzburg, Wurzburg, Germany
    Am J Reprod Immunol 58:129-37. 2007
    ..Cytokines and chemokines have been suggested as key factors for the regulation of these complex cellular migration and interaction processes...
  80. ncbi Cytogenetic diagnosis of "normal 46,XX" karyotypes in spontaneous abortions frequently may be misleading
    K A Bell
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, USA
    Fertil Steril 71:334-41. 1999
    ....
  81. ncbi [Prenatal diagnostics in Arhus and Viborg Counties after implementation of first trimester risk assessment]
    Niels Tørring
    Arhus Universitetshospital, Skejby, Klinisk Biokemisk Afdeling, Arhus N
    Ugeskr Laeger 170:50-4. 2008
    ....
  82. ncbi HbA1c levels are significantly lower in early and late pregnancy
    Lene R Nielsen
    Department of Endocrinology, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark
    Diabetes Care 27:1200-1. 2004
  83. ncbi Cellular localization of gonadotropin-releasing hormone (GnRH) I and GnRH II in first-trimester human placenta and decidua
    Chun Shan Chou
    Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, British Columbia, Canada V6H 3V5
    J Clin Endocrinol Metab 89:1459-66. 2004
    ....
  84. ncbi First trimester placental growth factor and soluble fms-like tyrosine kinase 1 and risk for preeclampsia
    Ravi Thadhani
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 89:770-5. 2004
    ..7-fold (95% confidence interval, 2.3-351.0) in the third (<12 pg/ml) compared with the first (>39 pg/ml) PlGF tertile. First trimester serum levels of PlGF and sFlt1 may identify women at high risk for PE...
  85. pmc Human cytomegalovirus transmission from the uterus to the placenta correlates with the presence of pathogenic bacteria and maternal immunity
    Lenore Pereira
    Departments of Stomatology, University of California San Francisco, San Francisco, California 94143 0512, USA
    J Virol 77:13301-14. 2003
    ..These results suggest that the outcome of cytomegalovirus infection depends on the presence of other pathogens and coordinated immune responses to viral replication at the maternal-fetal interface...
  86. ncbi First-trimester C-reactive protein and subsequent gestational diabetes
    Myles Wolf
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Diabetes Care 26:819-24. 2003
    ..We tested the hypothesis that increased inflammation, measured early in pregnancy, is associated with the subsequent development of gestational diabetes mellitus (GDM), a precursor of type 2 diabetes...
  87. ncbi Nuchal translucency and first trimester biochemical markers for down syndrome screening: a cost-effectiveness analysis
    Aaron B Caughey
    Department of Obstetrics and Gynecology, University of California, San Francisco, USA
    Am J Obstet Gynecol 187:1239-45. 2002
    ..The purpose of this study was to perform a cost-effectiveness analysis that compared the first- and second- trimester screening tools for Down syndrome...
  88. ncbi Antenatal Down syndrome screening in the United States in 2001: a survey of maternal-fetal medicine specialists
    James F X Egan
    Division of Maternal Fetal Medicine, Department of Obstetrics, St Francis Hospital and Medical Center, Hartford, Conn, USA
    Am J Obstet Gynecol 187:1230-4. 2002
    ..Our objectives were to determine patterns of antenatal Down syndrome screening and risk adjustment by maternal-fetal medicine specialists in the United States in 2001...
  89. ncbi One single dose of 200 microg of antenatal RhIG halves the risk of anti-D immunization and hemolytic disease of the fetus and newborn in the next pregnancy
    Joke M Koelewijn
    Sanquin Research, Amsterdam, The Netherlands
    Transfusion 48:1721-9. 2008
    ....
  90. ncbi Specific tumour-associated methylation in normal human term placenta and first-trimester cytotrophoblasts
    B Novakovic
    Developmental Epigenetics Research, Murdoch Children s Research Institute, Royal Children s Hospital, VIC 3052, Australia
    Mol Hum Reprod 14:547-54. 2008
    ....
  91. pmc First-trimester fasting hyperglycemia and adverse pregnancy outcomes
    Shlomit Riskin-Mashiah
    Department of Obstetrics and Gynecology, The Lady Davis Carmel Medical Center, Rappaport Faculty of Medicine, Technion, Haifa, Israel
    Diabetes Care 32:1639-43. 2009
    ..Our aim was to evaluate the associations between first-trimester fasting plasma glucose level and adverse pregnancy outcomes...
  92. ncbi Serum progesterone testing to predict ectopic pregnancy in symptomatic first-trimester patients
    R G Buckley
    Departments of Emergency Medicine, Clinical Investigations, Radiology, and Obstetrics and Gynecology, Naval Medical Center San Diego, CA, USA
    Ann Emerg Med 36:95-100. 2000
    ..This study was conducted to prospectively measure the accuracy of serum progesterone levels to detect ectopic pregnancy...
  93. ncbi Preferences of women facing a prenatal diagnostic choice: long-term outcomes matter most
    M Kuppermann
    Department of Obstetrics, Gynecology and Reproductive Sciences, School of Medicine, University of California, San Francisco, 94143 0856, USA
    Prenat Diagn 19:711-6. 1999
    ..Furthermore, the substantial variation in utilities we observed suggests that future prenatal testing policies should account for the preferences of the individual woman...
  94. pmc Delay between pregnancy confirmation and sickle cell and [corrected] thalassaemia screening: a population-based cohort study
    Elizabeth Dormandy
    Department of Psychology at Guy s, Health Psychology Section, Institute of Psychiatry, King s College London, London, UK
    Br J Gen Pract 58:154-9. 2008
    ..Antenatal sickle cell and thalassaemia screening sometimes occurs too late to allow couples a choice regarding termination of affected fetuses. The target gestational age for offering the test in the UK is 10 weeks...
  95. ncbi Validity of a modified Pregnancy-Unique Quantification of Emesis and Nausea (PUQE) scoring index to assess severity of nausea and vomiting of pregnancy
    Anaïs Lacasse
    Faculty of Pharmacy, University of Montreal, Montreal, QC, Canada
    Am J Obstet Gynecol 198:71.e1-7. 2008
    ....
  96. ncbi Preconception care and the risk of congenital anomalies in the offspring of women with diabetes mellitus: a meta-analysis
    J G Ray
    Division of Obstetrical Medicine, Department of Medicine, Women s College Campus, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario, Canada
    QJM 94:435-44. 2001
    ....
  97. ncbi Nuchal translucency and fetal cardiac defects: a pooled analysis of major fetal echocardiography centers
    George Makrydimas
    Department of Obstetrics and Gynecology, University Hospital of Ioannina, Greece
    Am J Obstet Gynecol 192:89-95. 2005
    ..In the present study, we aimed to investigate whether fetal nuchal translucency distribution differs among different types of congenital heart defects and whether it can lead to an earlier diagnosis...
  98. ncbi First two months of pregnancy--critical time for preterm delivery and low birthweight caused by adverse effects of coal combustion toxics
    Lucijan Mohorovic
    Obstetric and Gynecologic Primary Care, Labin, Rabac 52221, Croatia
    Early Hum Dev 80:115-23. 2004
    ..The objective of this study was to define the most critical gestation period for adverse effects of environmental toxics in terms of preterm delivery (<37 weeks) and low birthweight (<2500 g) in humans...
  99. ncbi Improved first-trimester Down syndrome screening performance by lowering the false-positive rate: a prospective study of 9941 low-risk women
    K R Wøjdemann
    Copenhagen University Hospital, Department of Obstetrics and Gynaecology, Hvidovre Hospital, Copenhagen, Denmark
    Ultrasound Obstet Gynecol 25:227-33. 2005
    ....
  100. ncbi Multicenter study of first-trimester screening for trisomy 21 in 75 821 pregnancies: results and estimation of the potential impact of individual risk-orientated two-stage first-trimester screening
    K H Nicolaides
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, London, UK
    Ultrasound Obstet Gynecol 25:221-6. 2005
    ..In addition, the potential impact of a new individual risk-orientated two-stage approach to first-trimester screening was examined...
  101. ncbi Does fetal screening affect women's worries about the health of their baby? A randomized controlled trial of ultrasound screening for Down's syndrome versus routine ultrasound screening
    Susanne Georgsson Ohman
    Department of Nursing, Karolinska Institutet, Stockholm, Sweden
    Acta Obstet Gynecol Scand 83:634-40. 2004
    ..The aim of this study was to evaluate the effect of ultrasound screening for Down's syndrome on women's anxiety in mid-pregnancy and 2 months after delivery...

Research Grants64

  1. Inhibin/Activin Family in Human Cranifocial Development
    Geralyn Messerlian; Fiscal Year: 2003
    ..abstract_text> ..
  2. MECHANISMS OF PRETERM LABOR: NF-KB ACTIVATION OF COX-2
    DOUGLAS KNISS; Fiscal Year: 2001
    ....
  3. Dietary Patterns, Obesity and Associated Metabolic Outcomes in Adolescent Girls
    LYNN MOORE; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  4. PRENATAL COCAINE USE--10 YEAR FOLLOW UP
    GALE RICHARDSON; Fiscal Year: 2003
    ..abstract_text> ..
  5. Contraceptive efficacy and body weight: Does obesity affect the risk of failure?
    Alison Edelman; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  6. Improving Contraceptive Effectiveness in Obese Women
    Alison B Edelman; Fiscal Year: 2010
    ..abstract_text> ..
  7. Cardiovascular Consequences of Thyroid Dysfunction
    Elizabeth Pearce; Fiscal Year: 2007
    ..Pearce's career as an independent academic clinical investigator with a focus on thyroid disease and epidemiology. ..
  8. The Effects of Perceived Discrimination on Mental and Physical Health
    BRENDA N MAJOR; Fiscal Year: 2010
    ..abstract_text> ..
  9. Future Directions in Contingency Management Research
    Stephen Higgins; Fiscal Year: 2004
    ..g., cognitive behavior therapy). Critical discussion of these issues is important to the future of CM and to the research agenda of NIDA. ..
  10. Pregnancy Influences Environmental Sensitivity
    Laura Glynn; Fiscal Year: 2005
    ..abstract_text> ..
  11. BAYLOR BIRCWH PROGRAM
    Joe Simpson; Fiscal Year: 2004
    ..These goals are vital to public health in contributing to the establishment of methods for production of safe, effective, quality herbal extracts for consumer use. ..
  12. Role of Cytokines and Promoter Genotype in Prematurity
    Hyagriv Simhan; Fiscal Year: 2007
    ..abstract_text> ..
  13. Media Effects on Eating Disorder Symptoms: Meta-analysis
    Heather Hausenblas; Fiscal Year: 2005
    ....
  14. TREATING COCAINE ABUSE: A BEHAVIORAL APPROACH
    Stephen Higgins; Fiscal Year: 2007
    ..abstract_text> ..
  15. Combinatorial Signals & Gene Expression in Trophoblasts
    Mark Roberson; Fiscal Year: 2006
    ....
  16. Trophoblast Selectins and Their Uterine Mucin Ligands
    Susan Fisher; Fiscal Year: 2006
    ..abstract_text> ..
  17. Ambient Air Pollution, Preeclampsia, and Preterm Delivery
    Michelle Williams; Fiscal Year: 2008
    ..The results could also contribute to the body of heath-related science that influences air quality standards and policies. [unreadable] [unreadable] [unreadable]..
  18. SPATIAL REGULATION OF PKA BY AKAP-RI INTERACTIONS
    GEORGE GERTON; Fiscal Year: 2008
    ..These studies will advance our knowledge of early mammalian development, and are relevant to clinical problems of infertility and the procedures used in assisted reproduction. [unreadable] [unreadable]..
  19. Fetal Swallowing: Central Dipsogenic Mechanisms
    Michael Ross; Fiscal Year: 2007
    ..Furthermore, these studies represent a model to examine the development and function of neuronal pathways and mechanisms regulating fetal physiology. ..
  20. MOLECULAR MECHANISMS--BACTERIAL ADHERENCE TO CEMENTUM
    Susan Fisher; Fiscal Year: 2008
    ..This greatly simplifies the design of artificial salivary molecules that mimic the natural bacterial receptor activity of this fluid, as well as competitive inhibitors of plaque formation. ..
  21. Fertilization and Activation of Development 2007 Gordon Research Conference
    GEORGE GERTON; Fiscal Year: 2007
    ..The conference will promote collaborations among US [unreadable] and international scientists with widely disparate experiences/seniority, methodologies, [unreadable] and model systems. [unreadable] [unreadable] [unreadable] [unreadable]..
  22. Overweight in Children: A New View Using the Population Attributable Fraction
    Deborah Rosenberg; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  23. Vitamin D in Obstructive Lung Diseases
    Augusto Litonjua; Fiscal Year: 2008
    ..Additionally, supplementation with vitamin D can be implemented in cost-effective population-based programs to prevent the development of, and treat these disorders. [unreadable] [unreadable] [unreadable]..
  24. Defects in Mitochondria Impacting Primate Oocyte Quality
    DAVID RANDALL ARMANT; Fiscal Year: 2010
    ..Information gained in this study will also improve our understanding of the role of mitochondria in primate oocyte and embryo biology, and in the progressive loss of female reproductive capacity with age. ..
  25. OMEGA-3 SUPPLMENTATION DECREASES INFLAMMATION AND FETAL OBESITY IN PREGNANCY
    Sylvie Hauguel De Mouzon; Fiscal Year: 2010
    ..Pretiminary data witt also be obtained on fetat body composition in order to later address the prevention of the long term adverse effects (devetopmental programming) of maternal obesity in the developing fetus. ..
  26. Voucher-based incentives to treat pregnant smokers
    Stephen T Higgins; Fiscal Year: 2010
    ..Overall, the proposed studies have the potential to contribute important new information on effective treatments for one of our nation's most daunting drug abuse problems. ..
  27. Nutrition and the Genetics of Prematurity
    Hyagriv N Simhan; Fiscal Year: 2010
    ..Finally, we aim to identify how race modifies the interaction between inflammatory gene polymorphisms and nutrition on lower genital tract immunity and the risk of preterm birth. ..
  28. Modeling Initial Smoking Abstinence and Relapse Risk
    Stephen T Higgins; Fiscal Year: 2010
    ....
  29. Expanded Prenatal Testing Options and Informed Choice
    Miriam Kuppermann; Fiscal Year: 2010
    ..In short, this study will generate a useful decision-assisting tool and provide information for use in designing cost-effective testing programs that allow for variation in preferences. ..
  30. Gene by Environment Interactions in Asthma and Allergy
    Augusto Litonjua; Fiscal Year: 2009
    ..Blood for genetic material is currently being collected on the two cohorts, and endotoxin will be measured from stored, frozen house dust. ..
  31. Prenatal MF Exposure & Miscarriage Risk Among Women
    De Kun Li; Fiscal Year: 2009
    ..The findings from the proposed study will provide much needed confirmation of the recently reported results and advance our understanding of a MF health effect. ..
  32. Neuronal Guidance Mechanisms in Placental Development
    Susan Fisher; Fiscal Year: 2009
    ..In doing so, we will gain important insights into the etiology of PE, GTDs and, perhaps, other types of tumors. ..
  33. Women and Smoking: Understanding Socioeconomic Influences
    Stephen Higgins; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  34. Theoretical Assessment of Exercise Beliefs During Pregnancy
    Heather Hausenblas; Fiscal Year: 2008
    ..3) Examine physical activity levels during each trimester. And (4) explore potential mediators and moderators of the theory of behavior. [unreadable] [unreadable] [unreadable]..
  35. The Role of Inflammation and Parity on GDM and Type 2 DM
    Wanda Nicholson; Fiscal Year: 2008
    ..This award will give Dr. Nicholson the dedicated time and experience she needs to develop into an independent clinical investigator [unreadable] [unreadable]..
  36. Prenatal Risk Factors for Neuropsychiatric Disease
    Carolyn Salafia; Fiscal Year: 2007
    ..My training objectives are directly related to my proposed research, which focuses on the evaluation of the intrauterine environment and how predispositions to ND/NP compromise arise in utero. ..
  37. Exposure to Bisphenol A & Reproductive Effect in Humans
    De Kun Li; Fiscal Year: 2007
    ..The proposed study will evaluate the reproductive effects of BPA in settings where there have been high levels of exposure. The study will also investigate effects in multiple human generations. ..
  38. Role of 10-formyldihydrofolate in purine biosynthesis
    Tsunenobu Tamura; Fiscal Year: 2004
    ..If this pathway is proven, derivatives of 10-HCO-H2folate could be used to inhibit de novo purine biosynthesis for developing new anticancer drugs. ..
  39. CENTER FOR STUDY OF GROWTH REGULATION IN HUMAN PREGNANCY
    Patrick Catalano; Fiscal Year: 2004
    ..abstract_text> ..
  40. A NOVEL VASCULOGENESIS PROGRAM IN CYTOTROPHOBLASTS
    Susan Fisher; Fiscal Year: 2003
    ..Whether these mechanisms could inhibit tumor-induced angiogenesis, and consequently tumor growth, is another intriguing possibility. ..
  41. WOMEN'S REPRODUCTIVE HEALTH RESEARCH CAREER DEVELOPMENT
    W Hogge; Fiscal Year: 2003
    ..We believe that the organization, resources, enthusiastic young faculty and an exceptional group of senior faculty combined with resources of the WRHR Center provides an exceptional opportunity for the potential physician scientist. ..
  42. MATERNAL DEHYDRATION--FETAL/AMNIOTIC FLUID HOMEOSTASIS
    Michael Ross; Fiscal Year: 2002
    ..The goal of this project is to determine critical efficacy and fetal safety issues central to maternal DDAVP treatment, prior to widespread clinical use in human pregnancies with oligohydramnios. ..
  43. ORAL CONTRACEPTIVES FOR DYSMENORRHEA IN ADOLESCENT GIRLS
    Anne Davis; Fiscal Year: 2002
    ..Given their efficacy in pregnancy prevention, safety, and non-contraceptive health benefits, COC may be an ideal therapy for primary dysmenorrhea in adolescent girls. ..
  44. LEPTIN & NEUROPEPTIDE-Y ALTERS FETAL SWALLOWING ACTIVITY
    Michael Ross; Fiscal Year: 2002
    ..In addition, these studies represent a model to examine the development and function of neuronal pathways and mechanisms which regulate fetal physiology. ..
  45. VIOLENCE AND SPONTANEOUS ABORTION IN INNER CITY WOMEN
    Deborah Nelson; Fiscal Year: 2002
    ....
  46. ETHANOL, SIGNAL TRANSDUCTION AND EMBRYONIC CELL SURVIVAL
    DAVID ARMANT; Fiscal Year: 2002
    ..The proposed experiments may identify signal transduction inhibitors or growth factors to ameliorate the downstream effects of ethanol in vitro, and suggest strategies for therapeutic intervention during pregnancy. ..
  47. PREVENTION AND TREATMENT OF HUMAN OLIGOHYDRAMNIOS
    Michael Ross; Fiscal Year: 2001
    ..e., failure to reset osmolality threshold). This proposal will aid in the development of markers of prediction and therapeutic approaches to the prevention and treatment of human oligohydramnios. ..
  48. Genomics of Human Fetal Morphogenesis
    Jeanne Manson; Fiscal Year: 2004
    ..abstract_text> ..
  49. Fetal Membrane AQP Expression/Amniotic Fluid Regulation
    Michael Ross; Fiscal Year: 2004
    ..Our objective is to determine the regulatory mechanisms of fetal membrane AQP expression and delineate the role of AQPs in AF homeostasis. ..
  50. ACROSOMAL MATRIX, EXOCYTOSIS AND MAMMALIAN FERTILIZATION
    GEORGE GERTON; Fiscal Year: 2007
    ..abstract_text> ..
  51. A Run-to-Run Algorithm for Glucose Regulation
    Lois Jovanovic; Fiscal Year: 2005
    ..The exchange of personnel will be facilitated, allowing the student and post-doc supported on this project to work at both the institute and the university over the span of the project ..
  52. Intermediate Outcomes of Hysterectomy and Alternatives
    Miriam Kuppermann; Fiscal Year: 2006
    ..abstract_text> ..
  53. Oral contraceptives and cytochrome p450 inducers
    Anne Davis; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  54. The Epidemiology of Marine Fatty Acids and Preeclampsia
    Michelle Williams; Fiscal Year: 2006
    ....
  55. Multimedia for Exercise During Pregnancy and Postpartum
    Heather Hausenblas; Fiscal Year: 2005
    ....
  56. Outcomes in congenital toxoplasmic retinochoroiditis
    Ruth Gilbert; Fiscal Year: 2005
    ..abstract_text> ..
  57. INDUCED ABORTION AND BREAST CANCER RISK
    De Kun Li; Fiscal Year: 2001
    ....
  58. Prenatal NSAID Use and Miscarriage
    De Kun Li; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  59. Literacy and Utilization of Maternal Depression Care
    Ian Bennett; Fiscal Year: 2006
    ..This study represents a unique and cost effective opportunity to study patient factors which are obstacles to depression treatment in women with low literacy and inform future interventions. ..
  60. Two-photon excited fluorescence imaging of placental vasculature in vivo
    Mark Roberson; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  61. Comprehensive non-invasive prenatal diagnostics
    Eugene Pergament; Fiscal Year: 2004
    ..abstract_text> ..
  62. Prenatal Ultrasound And Birth Defects
    DOROTHY WALLER; Fiscal Year: 2008
    ..Estimates of sensitivity and specificity will be calculated for each of 38 different categories of malformations. [unreadable] [unreadable] [unreadable]..