placentation

Summary

Summary: The development of the PLACENTA, a highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products between mother and FETUS. The process begins at FERTILIZATION, through the development of CYTOTROPHOBLASTS and SYNCYTIOTROPHOBLASTS, the formation of CHORIONIC VILLI, to the progressive increase in BLOOD VESSELS to support the growing fetus.

Top Publications

  1. ncbi From ancestral infectious retroviruses to bona fide cellular genes: role of the captured syncytins in placentation
    A Dupressoir
    Unité des rétrovirus endogènes et éléments rétroïdes des eucaryotes supérieurs, CNRS, UMR 8122, Institut Gustave Roussy, 114 rue Edouard Vaillant, 94805 Villejuif, France
    Placenta 33:663-71. 2012
  2. pmc Paleovirology of 'syncytins', retroviral env genes exapted for a role in placentation
    Christian Lavialle
    UMR 8122, Unité des rétrovirus endogènes et éléments rétroïdes des eucaryotes supérieurs, CNRS, Institut Gustave Roussy, 94805 Villejuif, France
    Philos Trans R Soc Lond B Biol Sci 368:20120507. 2013
  3. ncbi Immunology of placentation in eutherian mammals
    Ashley Moffett
    King s College, Cambridge CB2 1ST, UK
    Nat Rev Immunol 6:584-94. 2006
  4. pmc Ancestral capture of syncytin-Car1, a fusogenic endogenous retroviral envelope gene involved in placentation and conserved in Carnivora
    Guillaume Cornelis
    Unité des rétrovirus endogènes et éléments rétroïdes des eucaryotes supérieurs, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8122, Institut Gustave Roussy, F 94805 Villejuif, France
    Proc Natl Acad Sci U S A 109:E432-41. 2012
  5. ncbi The influence of the intrauterine environment on human placental development
    Graham J Burton
    Centre for Trophoblast Research, University of Cambridge, Cambridge, UK
    Int J Dev Biol 54:303-12. 2010
  6. ncbi Placentation and maternal investment in mammals
    Isabella Capellini
    Evolutionary Anthropology Research Group, Department of Anthropology, Durham University, Dawson Building, South Road, Durham DH1 3LE, United Kingdom
    Am Nat 177:86-98. 2011
  7. ncbi IFPA Award in Placentology Lecture: Complicated interactions between genes and the environment in placentation, pregnancy outcome and long term health
    C T Roberts
    Robinson Institute, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, South Australia 5005, Australia
    Placenta 31:S47-53. 2010
  8. ncbi Targeted disruption of the murine VCAM1 gene: essential role of VCAM-1 in chorioallantoic fusion and placentation
    G C Gurtner
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115
    Genes Dev 9:1-14. 1995
  9. pmc Differential evolutionary fate of an ancestral primate endogenous retrovirus envelope gene, the EnvV syncytin, captured for a function in placentation
    Cécile Esnault
    Unité des rétrovirus endogènes et éléments rétroïdes des eucaryotes supérieurs, Unité Mixte de Recherche 8122, Centre National de la Recherche Scientifique, Institut Gustave Roussy, Villejuif, France
    PLoS Genet 9:e1003400. 2013
  10. ncbi High serum oestradiol concentrations in IVF cycles increase the risk of pregnancy complications related to abnormal placentation
    Jacob Farhi
    Infertility and IVF Unit, Department of Obstetrics and Gynecology, Helen Schneider Hospital for Women, Beilinson Campus, Rabin Medical Center, Petach Tikva 49100, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Reprod Biomed Online 21:331-7. 2010

Detail Information

Publications288 found, 100 shown here

  1. ncbi From ancestral infectious retroviruses to bona fide cellular genes: role of the captured syncytins in placentation
    A Dupressoir
    Unité des rétrovirus endogènes et éléments rétroïdes des eucaryotes supérieurs, CNRS, UMR 8122, Institut Gustave Roussy, 114 rue Edouard Vaillant, 94805 Villejuif, France
    Placenta 33:663-71. 2012
    ..out one or both mouse syncytin-A and -B genes provided evidence that they indeed play a critical role in placentation. We discuss the possibility that the immunosuppressive domain embedded within retroviral envelope glycoproteins ..
  2. pmc Paleovirology of 'syncytins', retroviral env genes exapted for a role in placentation
    Christian Lavialle
    UMR 8122, Unité des rétrovirus endogènes et éléments rétroïdes des eucaryotes supérieurs, CNRS, Institut Gustave Roussy, 94805 Villejuif, France
    Philos Trans R Soc Lond B Biol Sci 368:20120507. 2013
    ....
  3. ncbi Immunology of placentation in eutherian mammals
    Ashley Moffett
    King s College, Cambridge CB2 1ST, UK
    Nat Rev Immunol 6:584-94. 2006
    ..At the implantation site, cells from the mother and the fetus intermingle during pregnancy. Unravelling what happens here is crucial to our understanding of why some human pregnancies are successful whereas others are not...
  4. pmc Ancestral capture of syncytin-Car1, a fusogenic endogenous retroviral envelope gene involved in placentation and conserved in Carnivora
    Guillaume Cornelis
    Unité des rétrovirus endogènes et éléments rétroïdes des eucaryotes supérieurs, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8122, Institut Gustave Roussy, F 94805 Villejuif, France
    Proc Natl Acad Sci U S A 109:E432-41. 2012
    Syncytins are envelope protein genes of retroviral origin that have been captured for a function in placentation. Two such genes have already been identified in simians, two distinct, unrelated genes have been identified in Muridae, and a ..
  5. ncbi The influence of the intrauterine environment on human placental development
    Graham J Burton
    Centre for Trophoblast Research, University of Cambridge, Cambridge, UK
    Int J Dev Biol 54:303-12. 2010
    ..Protein synthesis inhibition therefore appears to be a common mechanism for regulating placental development under different adverse conditions...
  6. ncbi Placentation and maternal investment in mammals
    Isabella Capellini
    Evolutionary Anthropology Research Group, Department of Anthropology, Durham University, Dawson Building, South Road, Durham DH1 3LE, United Kingdom
    Am Nat 177:86-98. 2011
    ..We suggest that the effects of placental interdigitation on growth rates and the way that these are traded off against gestation length may be promising avenues for understanding the evolutionary dynamics of parent-offspring conflict...
  7. ncbi IFPA Award in Placentology Lecture: Complicated interactions between genes and the environment in placentation, pregnancy outcome and long term health
    C T Roberts
    Robinson Institute, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, South Australia 5005, Australia
    Placenta 31:S47-53. 2010
    ..b>Placentation and trophoblast invasion and its inhibitors in other species may provide new ideas for understanding what goes ..
  8. ncbi Targeted disruption of the murine VCAM1 gene: essential role of VCAM-1 in chorioallantoic fusion and placentation
    G C Gurtner
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115
    Genes Dev 9:1-14. 1995
    ..A small number of VCAM-1-deficient embryos survived, presumably by circumventing the placentation defects...
  9. pmc Differential evolutionary fate of an ancestral primate endogenous retrovirus envelope gene, the EnvV syncytin, captured for a function in placentation
    Cécile Esnault
    Unité des rétrovirus endogènes et éléments rétroïdes des eucaryotes supérieurs, Unité Mixte de Recherche 8122, Centre National de la Recherche Scientifique, Institut Gustave Roussy, Villejuif, France
    PLoS Genet 9:e1003400. 2013
    Syncytins are envelope genes of retroviral origin that have been co-opted for a role in placentation. They promote cell-cell fusion and are involved in the formation of a syncytium layer--the syncytiotrophoblast--at the materno-fetal ..
  10. ncbi High serum oestradiol concentrations in IVF cycles increase the risk of pregnancy complications related to abnormal placentation
    Jacob Farhi
    Infertility and IVF Unit, Department of Obstetrics and Gynecology, Helen Schneider Hospital for Women, Beilinson Campus, Rabin Medical Center, Petach Tikva 49100, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Reprod Biomed Online 21:331-7. 2010
    ..concentration on human chorionic gonadotrophin (HCG) day in IVF cycles on endometrial receptivity and placentation. A retrospective cohort included all women attending the IVF unit in 2006 and 2007, with the best prognosis to ..
  11. pmc Rat placentation: an experimental model for investigating the hemochorial maternal-fetal interface
    M J Soares
    Institute for Reproductive Health and Regenerative Medicine, Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Placenta 33:233-43. 2012
    The rat possesses hemochorial placentation with deep intrauterine trophoblast cell invasion and trophoblast-directed uterine spiral artery remodeling; features shared with human placentation...
  12. ncbi Dickkopf-1 secreted by decidual cells promotes trophoblast cell invasion during murine placentation
    Sha Peng
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Datun Road, Chaoyang District, Beijing 100101, China
    Reproduction 135:367-75. 2008
    ..However, the role of Dkk1 in trophoblast cell invasion during placentation remains unclear...
  13. ncbi The mammalian yolk sac placenta
    Claudia Freyer
    Department of Zoology, The University of Melbourne, Melbourne, Victoria, Australia
    J Exp Zool B Mol Dev Evol 312:545-54. 2009
    ..Thus, the yolk sac of humans, like that of all viviparous mammals, is a true placenta crucial for early embryonic development and survival...
  14. pmc Regulation of cell surface protease matriptase by HAI2 is essential for placental development, neural tube closure and embryonic survival in mice
    Roman Szabo
    Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Development 136:2653-63. 2009
    ..This study indicates that unregulated matriptase-dependent cell surface proteolysis can cause a diverse array of abnormalities in mammalian development...
  15. pmc Endogenous retroviruses in trophoblast differentiation and placental development
    Sarah G Black
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, TX 77843 2471, USA
    Am J Reprod Immunol 64:255-64. 2010
    ....
  16. ncbi Deep placentation
    R Pijnenborg
    Department of Woman and Child, University Hospital Leuven, B 3000 Leuven, Belgium
    Best Pract Res Clin Obstet Gynaecol 25:273-85. 2011
    Deep placentation in human pregnancy is realised by deep invasion of the placental bed by the extravillous trophoblast, involving the decidua and the inner (junctional zone) myometrium...
  17. ncbi Oxygen and placental development during the first trimester: implications for the pathophysiology of pre-eclampsia
    I Caniggia
    Samuel Lunenfeld Research Institute, Department of Obstetrics and Gynaecology, Mount Sinai Hospital, Toronto, Ontario, Canada
    Placenta 21:S25-30. 2000
    During early pregnancy, placentation occurs in a relatively hypoxic environment which is essential for appropriate embryonic development...
  18. ncbi Cytokines, chemokines and growth factors in endometrium related to implantation
    E Dimitriadis
    Prince Henry s Institute of Medical Research, P O Box 5152, Clayton, Victoria 3168, Australia
    Hum Reprod Update 11:613-30. 2005
    The complexity of the events of embryo implantation and placentation is exemplified by the number and range of cytokines with demonstrated roles in these processes...
  19. ncbi Abnormal placentation: twenty-year analysis
    Serena Wu
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Chicago, Ill, USA
    Am J Obstet Gynecol 192:1458-61. 2005
    This study was undertaken to determine whether the rate of abnormal placentation is increasing in conjunction with the cesarean rate and to evaluate incidence, risk factors, and outcomes.
  20. pmc Maternal activating KIRs protect against human reproductive failure mediated by fetal HLA-C2
    Susan E Hiby
    Department of Pathology, University of Cambridge, Cambridge, UK
    J Clin Invest 120:4102-10. 2010
    ..by the fetal trophoblast cells and killer Ig-like receptors (KIRs) on the maternal uNK cells--influence placentation in human pregnancy...
  21. ncbi A guide towards pre-pregnancy management of defective implantation and placentation
    Adam C Urato
    Department of Obstetrics and Gynecology, Tufts Medical Center and Tufts University School of Medicine, 800 Washington Street, Boston, MA 02111, USA
    Best Pract Res Clin Obstet Gynaecol 25:367-87. 2011
    ..Currently, the cause of such complications are being increasingly recognised as defective implantation and placentation. The molecular mechanisms responsible for normal and abnormal implantation are an area of active investigation...
  22. ncbi A novel serine protease of the mammalian HtrA family is up-regulated in mouse uterus coinciding with placentation
    Gui Ying Nie
    Prince Henry s Institute of Medical Research, P O Box 5152, 246 Clayton Road, Clayton, Victoria 3168, Australia
    Mol Hum Reprod 9:279-90. 2003
    ..Based on PRSP protein domain structure and its unique expression during pregnancy, we propose that PRSP plays an important role in the formation/function of the placenta...
  23. pmc Placentation in Sigmodontinae: a rodent taxon native to South America
    Phelipe O Favaron
    Department of Surgery, School of Veterinary Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Reprod Biol Endocrinol 9:55. 2011
    ..Sigmodontinae, known as "New World rats and mice," is a large subfamily of Cricetidae for which we herein provide the first comprehensive investigation of the placenta...
  24. ncbi Altered plasma concentrations of leptin, transforming growth factor-beta(1) and plasminogen activator inhibitor type 2 at 18 weeks of gestation in women destined to develop pre-eclampsia. Circulating markers of disturbed placentation?
    T Clausen
    Department of Obstetrics and Gynaecology, Aker and Ulleval University Hospitals, Oslo, Norway
    Placenta 23:380-5. 2002
    In many pre-eclamptic women the placentation process seems to be disturbed...
  25. ncbi How Does the maternal immune system contribute to the development of pre-eclampsia?
    A Moffett
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Placenta 28:S51-6. 2007
    ..When considering the primary defect of placentation that leads to pre-eclampsia the focus should be on the intermingling of the invasive placental trophoblast ..
  26. ncbi Embryo-maternal communication: signalling before and during placentation in cattle and pig
    Esben Ostrup
    Section of Biomaterials, University of Oslo, PO Box 1109, Blindern, 0317 Oslo, Norway
    Reprod Fertil Dev 23:964-75. 2011
    ..and transcriptional changes in the endometrium as well as epigenetic regulation mechanisms directing the placentation. An increasing knowledge of the embryo-maternal communication might not only help to improve the fertility of ..
  27. pmc Review: Immunogenetics of human placentation
    P Parham
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA
    Placenta 33:S71-80. 2012
    ..favor reproductive success and other groups of receptors and ligands that have been correlated with disordered placentation. Human populations that have survived successive episodes of epidemic disease and population bottlenecks ..
  28. pmc Endocannabinoid signaling directs differentiation of trophoblast cell lineages and placentation
    Xiaofei Sun
    Division of Reproductive Sciences, Perinatal Institute, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 107:16887-92. 2010
    In most mammals, placentation is critical for fetal development and pregnancy success. Exposure to marijuana during pregnancy has adverse effects, but whether the placenta is a target of cannabinoid/endocannabinoid signaling is not known...
  29. ncbi The expression and function of cystatin C and cathepsin B and cathepsin L during mouse embryo implantation and placentation
    S Afonso
    Department of Cell, Developmental and Neurobiology, Nelson Labs, Busch Campus, Rutgers University, Piscataway, NJ 08855, USA
    Development 124:3415-25. 1997
    ..This work adds to our understanding of implantation and placentation by reporting the expression and function of another class of proteinases/inhibitors closely related to invasive ..
  30. ncbi A Cdh1HA knock-in allele rescues the Cdh1-/- phenotype but shows essential Cdh1 function during placentation
    Marc P Stemmler
    Department of Molecular Embryology, Max Planck Institute of Immunobiology, Freiburg, Germany
    Dev Dyn 239:2330-44. 2010
    ..Placentas without Cdh1 expression are impaired and incapable of establishing a proper connection between the embryonic and the maternal blood vessels for efficient nutrient and oxygen transport...
  31. ncbi An unusual feature of yolk sac placentation in Necromys lasiurus (Rodentia, Cricetidae, Sigmodontinae)
    P O Favaron
    Department of Surgery, School of Veterinary Medicine and Animal Science, University of Sao Paulo, Sao Paulo, Brazil
    Placenta 33:578-80. 2012
    We studied the development of the inverted yolk sac in a New World rodent, Necromys lasiurus during early placentation. Ten implantation sites were investigated by means of histology, immunohistochemistry and electron microscopy...
  32. pmc Dynamic evolution of endogenous retrovirus-derived genes expressed in bovine conceptuses during the period of placentation
    So Nakagawa
    Center for Information Biology, National Institute of Genetics, Japan
    Genome Biol Evol 5:296-306. 2013
    ..These results suggest that placentation depends on various retrovirus-derived genes that could have replaced endogenous predecessors during evolution.
  33. pmc Syncytin-A knockout mice demonstrate the critical role in placentation of a fusogenic, endogenous retrovirus-derived, envelope gene
    Anne Dupressoir
    Unité des rétrovirus endogènes et éléments rétroïdes des eucaryotes supérieurs, Unité Mixte de Recherche 8122, Centre National de Recherche Scientifique, Institut Gustave Roussy, 94805 Villejuif, and Université Paris Sud, 91405 Orsay, France
    Proc Natl Acad Sci U S A 106:12127-32. 2009
    ....
  34. ncbi Osteopontin: roles in implantation and placentation
    Greg A Johnson
    Center for Animal Biotechnology and Genomics, College of Veterinary Medicine, Texas A and M University, College Station, TX 77843, USA
    Biol Reprod 69:1458-71. 2003
    ..OPN has the potential to profoundly impact pregnancy, and investigators are now challenged to focus on the mechanistic nature of the functions of this multifaceted and major component of the uterine-placental microenvironment...
  35. ncbi Role of platelets in placentation
    Yukiyasu Sato
    Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto 606 8507, Japan
    Med Mol Morphol 43:129-33. 2010
    ..Future studies should aim to elucidate other mechanisms that could regulate endovascular trophoblast infiltration...
  36. ncbi A comparison of placental development and endocrine functions between the human and mouse model
    A Malassine
    INSERM U 427, Faculte des Sciences Pharmaceutiques et Biologiques, Universite Rene Descartes, Paris, France
    Hum Reprod Update 9:531-9. 2003
    ..Herein, the similarities and differences between the human and mouse models are reviewed, with a view to encouraging caution in the extrapolation of results from one model to the other...
  37. ncbi The evolutionary significance of placental interdigitation in mammalian reproduction: contributions from comparative studies
    I Capellini
    Department of Biological Sciences, University of Hull, Cottingham Road, Hull HU6 7RX, UK
    Placenta 33:763-8. 2012
    ..Contrary to suggestions that highly invasive hemochorial placentation is beneficial to fetal development, recent comparative studies have revealed that interdigitation - the degree ..
  38. ncbi Map2k1 and Map2k2 genes contribute to the normal development of syncytiotrophoblasts during placentation
    Valerie Nadeau
    Centre de recherche en cancérologie de l Université Laval, Centre Hospitalier Universitaire de Quebec, L Hôtel Dieu de Québec, Quebec, QC, G1R 2J6, Canada
    Development 136:1363-74. 2009
    ..Thus, even though Map2k1 plays a predominant role, these results enlighten the function of Map2k2 in placenta development...
  39. pmc How does variability of immune system genes affect placentation?
    F Colucci
    Department of Obstetrics and Gynaecology, University of Cambridge Clinical School, The Rosie Hospital, Cambridge, UK
    Placenta 32:539-45. 2011
    ..for major histocompatibility complex (MHC) molecules and natural killer receptors (NKR) may impact on human placentation. MHC and NKR are the most polymorphic human genes...
  40. ncbi Comparative placentation: some interesting modifications for histotrophic nutrition -- a review
    A C Enders
    Department of Cell Biology and Human Anatomy, University of California, One Shields Avenue, Davis, CA 95616, USA
    Placenta 27:S11-6. 2006
    ....
  41. ncbi Genomic imprinting in marsupial placentation
    Marilyn B Renfree
    Department of Zoology, ARC Centre of Excellence for Kangaroo Genomics, The University of Melbourne, Melbourne, Victoria 3010, Australia
    Reproduction 136:523-31. 2008
    ..there may have been strong selection for the retention of imprinted regions that arose during the evolution of placentation. There is currently no evidence for genomic imprinting in the egg-laying monotreme mammals...
  42. ncbi Cellular signatures in the primary visual cortex of phylogeny and placentation
    Eric Lewitus
    Department of Anthropology, University College London, London, WC1H 0BW, UK
    Brain Struct Funct 217:531-47. 2012
    ..We further tested cellular densities against mode of placentation to determine whether a relationship may exist...
  43. pmc Reduced prostasin (CAP1/PRSS8) activity eliminates HAI-1 and HAI-2 deficiency-associated developmental defects by preventing matriptase activation
    Roman Szabo
    Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Genet 8:e1002937. 2012
    ..Hypomorphic mutations in Prss8, encoding the GPI-anchored serine protease, prostasin (CAP1, PRSS8), restored placentation and normal development of HAI-1-deficient embryos and prevented early embryonic lethality, mid-gestation ..
  44. ncbi Costs and benefits of polyandry in a placental poeciliid fish Heterandria formosa are in accordance with the parent-offspring conflict theory of placentation
    O Ala-Honkola
    Department of Biological and Environmental Sciences, PO Box 65, 00014 University of Helsinki, Finland
    J Evol Biol 24:2600-10. 2011
    ..Offspring conflict may thus reduce the benefits of polyandry in viviparous species...
  45. ncbi Review: The evolving placenta: different developmental paths to a hemochorial relationship
    A C Enders
    Department of Cell Biology and Human Anatomy, School of Medicine, University of California Davis, Davis, CA 95616, USA
    Placenta 33:S92-8. 2012
    ..Variations from the major patterns of development also occur. The way in which the definitive placental form is achieved developmentally should be considered when using placental structure to extrapolate evolution of placentation.
  46. pmc Akt1 and insulin-like growth factor 2 (Igf2) regulate placentation and fetal/postnatal development
    Lindsey N Kent
    Institute for Reproductive Health and Regenerative Medicine, Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Int J Dev Biol 56:255-61. 2012
    Phenotypic characterization of Akt1 and Igf2 null mice has revealed roles for each in the regulation of placentation, and fetal and postnatal growth...
  47. ncbi Natural killer cells and pregnancy
    Ashley Moffett-King
    Department of Pathology, Cambridge University, Tennis Court Road, Cambridge CB2 1QP, UK
    Nat Rev Immunol 2:656-63. 2002
    ....
  48. ncbi Phylogenetic evidence for early hemochorial placentation in eutheria
    M G Elliot
    Department of Biological Sciences, Simon Fraser University, Burnaby, British Columbia, Canada V5A 1S6
    Placenta 30:949-67. 2009
    ..All of these approaches are consistent in indicating that highly invasive hemochorial placentation, as found in human beings and numerous other taxa, was an early evolutionary innovation present in the most ..
  49. pmc Oxygen, the Janus gas; its effects on human placental development and function
    Graham J Burton
    Centre for Trophoblast Research, Department of Physiology Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, UK
    J Anat 215:27-35. 2009
    ..Establishing an inviolable maternal blood supply for the second and third trimesters is therefore one of the most crucial aspects of human placentation.
  50. ncbi Glucocorticoids prevent the normal increase in placental vascular endothelial growth factor expression and placental vascularity during late pregnancy in the rat
    Damien P Hewitt
    School of Anatomy and Human Biology, The University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia
    Endocrinology 147:5568-74. 2006
    ..Our data suggest that glucocorticoid-induced restriction of fetal and placental growth is mediated, in part, via inhibition of placental VEGF expression and an associated reduction in placental vascularization...
  51. ncbi Maternal undernutrition influences placental-fetal development
    Louiza Belkacemi
    Department of Obstetrics and Gynecology, Harbor UCLA Medical Center, Los Angeles Biomedical Research Institute at Harbor UCLA, and David Geffen School of Medicine at UCLA, Torrance, California 90502, USA
    Biol Reprod 83:325-31. 2010
    ..This review associates fetal growth with maternal nutrition during pregnancy, placental growth and vascular development, and placental nutrient transport...
  52. ncbi Defective implantation and placentation: laying the blueprint for pregnancy complications
    Errol R Norwitz
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale New Haven Hospital, Yale University School of Medicine, 333 Cedar Street, LCI 800, New Haven, CT 06443, USA
    Reprod Biomed Online 13:591-9. 2006
    Normal implantation and placentation is critical for pregnancy success...
  53. ncbi Equine placentation
    W R Allen
    University of Cambridge, Department of Clinical Veterinary Medicine Equine Fertility Unit, Mertoun Paddocks, Newmarket, Suffolk, UK
    Reprod Fertil Dev 13:623-34. 2001
    ..Placental production of progesterone and 5alpha-reduced progestagens, on the other hand, depends on both maternal and fetal adrenal sources of pregnenelone...
  54. ncbi Association of maternal killer-cell immunoglobulin-like receptors and parental HLA-C genotypes with recurrent miscarriage
    S E Hiby
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Hum Reprod 23:972-6. 2008
    The natural killer (NK) cells at the site of placentation express killer-cell immunoglobulin-like receptors (KIR) that can bind to human leukocyte antigen (HLA)-C molecules on trophoblast cells...
  55. ncbi Differential expression of transcripts encoding retinoid binding proteins and retinoic acid receptors during placentation of the mouse
    V Sapin
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, C U de Strasbourg, Illkirch, France
    Dev Dyn 208:199-210. 1997
    ..5 to 19.5 days postcoitum (dpc). During early placentation, RBP and RALDH-2 gene expression are restricted to the endoderm of the visceral yolk sac and the outer uterine ..
  56. ncbi Chemokine CXCL16, a scavenger receptor, induces proliferation and invasion of first-trimester human trophoblast cells in an autocrine manner
    Yu Huang
    Laboratory for Reproductive Immunology, Hospital and Institute of Obstetrics and Gynecology, Shanghai Medical College, Fudan University, Shanghai, China
    Hum Reprod 21:1083-91. 2006
    ....
  57. ncbi Angiogenesis during primate placentation in health and disease
    Christine Wulff
    Department of Obstetrics and Gynaecology of the University of Ulm, Prittwitzstrasse 43, 89075 Ulm, Germany
    Reproduction 126:569-77. 2003
    ..In primates including humans, this exchange is attained by successful haemochorial placentation which requires the transformation of maternal intramyometrial spiral arterioles by trophoblast invasion to gain ..
  58. ncbi The effect of intrauterine growth retardation on the expression of developmental factors in porcine placenta subsequent to the initiation of placentation
    L A Blomberg
    Animal Biosciences and Biotechnology Laboratory, Animal and Natural Resources Institute, USDA Agricultural Research Service, Beltsville, MD 20705, USA
    Placenta 31:549-52. 2010
    ..Since ENOS could modulate vascular tone and angiogenesis via nitric oxide production, data suggest that the increase in IUGR may be an adaptive response to poor perfusion to maintain pregnancy...
  59. ncbi Role of HERV-W syncytin-1 in placentation and maintenance of human pregnancy
    Samina Noorali
    South Carolina Center for Biotechnology, Claflin University, Orangeburg, SC 29115, USA
    Appl Immunohistochem Mol Morphol 17:319-28. 2009
    ..The products of 2 of 16 identified genes of HERV-W seem to play a pivotal role in the placentation. These 2 genes are HERV-W env glycoprotein (syncytin-1) and HERV-FRD env glycoprotein (syncytin-2)...
  60. pmc Pathophysiology of placentation abnormalities in pregnancy-induced hypertension
    Mitsuko Furuya
    Department of Pathology, Yokohama City University Graduate School of Medicine, 3 9 Fuku ura, Kanazawa, Yokohama, Japan
    Vasc Health Risk Manag 4:1301-13. 2008
    ..Genetic susceptibilities and poor placentation have been investigated intensively to understand the pathophysiology of PIH...
  61. ncbi Human pregnancy: the role of chemokine networks at the fetal-maternal interface
    Kristy Red-Horse
    Department of Pathology, University of California San Francisco, 513 Parnassus Ave, San Francisco, CA 94143 0512, USA
    Expert Rev Mol Med 6:1-14. 2004
    ..Thus, as in other systems, at the fetal-maternal interface chemokines might regulate multiple functions...
  62. ncbi Effects of bisphenol A (BPA) on placentation and survival of the neonates in mice
    Toru Tachibana
    Laboratory of Basic Veterinary Science, United Graduate School of Veterinary Science, Yamaguchi University, Japan
    J Reprod Dev 53:509-14. 2007
    The effects of bisphenol A (BPA) on placentation have not been fully determined. The aim of this study was to clarify the structural changes of the placenta, abortion rate, and survival of neonates after BPA administration in mice...
  63. pmc Trophoblast stem cells: models for investigating trophectoderm differentiation and placental development
    Gordon C Douglas
    Wisconsin National Primate Research Center, University of Wisconsin, 1223 Capitol Court, Madison, Wisconsin 53715 1299, USA
    Endocr Rev 30:228-40. 2009
    ..In hemochorial placentation, these cells play especially important roles, interfacing with and modifying the cells of the maternal decidua...
  64. ncbi Uterine natural killer cells in species with epitheliochorial placentation
    H Engelhardt
    Department of Animal and Poultry Science, University of Guelph, Ont, Canada
    Nat Immun 15:53-69. 1996
    ..The best known examples of this form of placentation are the domestic livestock species...
  65. ncbi Evolution of invasive placentation with special reference to non-human primates
    Anthony M Carter
    Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, J B Winsloewsvej 21, DK 5000 Odense, Denmark
    Best Pract Res Clin Obstet Gynaecol 25:249-57. 2011
    It is now possible to view human placentation in an evolutionary context because advances in molecular phylogenetics provide a reliable scenario for the evolution of mammals...
  66. ncbi Prediction of macrosomia at birth in type-1 and 2 diabetic pregnancies with biomarkers of early placentation
    S Kuc
    Laboratory for Infectious Diseases and Screening, National Institute for Public Health and the Environment RIVM, Bilthoven, The Netherlands
    BJOG 118:748-54. 2011
    ..To evaluate the value of first trimester placental biomarkers (fβ-hCG, PAPP-A, ADAM12, PP13 and PlGF) and fetal nuchal translucency (NT) in the prediction of macrosomia at birth in pregestational type-1 and type-2 diabetes (PGDM)...
  67. pmc Placental-related diseases of pregnancy: Involvement of oxidative stress and implications in human evolution
    Eric Jauniaux
    Academic Department of Obstetrics and Gynaecology, Royal Free and University College London Medical School, London, UK
    Hum Reprod Update 12:747-55. 2006
    ..In contrast, in pre-eclampsia the trophoblastic invasion is sufficient to allow early pregnancy phases of placentation but too shallow for complete transformation of the arterial utero-placental circulation, predisposing to a ..
  68. ncbi Platelet-endothelial cell adhesion molecule-1 is expressed by a subpopulation of human trophoblasts: a possible mechanism for trophoblast-endothelial interaction during haemochorial placentation
    G Coukos
    Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia 19104 4283, USA
    Mol Hum Reprod 4:357-67. 1998
    ..adhesive interaction between trophoblasts and maternal vascular endothelium during the process of haemochorial placentation. Regulation of PECAM-1 expression by human trophoblasts may play a critical role in normal and abnormal ..
  69. ncbi Abnormal placentation, angiogenic factors, and the pathogenesis of preeclampsia
    Michelle Silasi
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Kirstein 3182, Boston, MA 02215, USA
    Obstet Gynecol Clin North Am 37:239-53. 2010
    ..The molecular pathogenesis of preeclampsia is just now being elucidated. It has been proposed that abnormal placentation and an imbalance in angiogenic factors lead to the clinical findings and complications seen in preeclampsia...
  70. ncbi Mid-trimester placentation assessment in high-risk pregnancies using maternal serum screening and uterine artery Doppler
    Reli Hershkovitz
    Maternal Medicine Clinic, The Obstetric Hospital, University College London Hospitals NHS Trust, London, UK
    Hypertens Pregnancy 24:273-80. 2005
    ..To determine the value of uterine artery velocimetry and mid-trimester maternal serum AFP/hCG measurements in predicting pregnancy complications in a high-risk group of pregnant patients...
  71. ncbi The evolving placenta: convergent evolution of variations in the endotheliochorial relationship
    A C Enders
    Department of Cell Biology and Human Anatomy, University of California Davis, School of Medicine, Davis CA 95616, USA
    Placenta 33:319-26. 2012
    ..It is concluded that the endotheliochorial placenta is more widespread and diversified than originally thought, with the variant with cellular trophoblast in particular appearing in several species studied recently...
  72. pmc The fetomaternal interface in the placenta of three species of armadillos (Eutheria, Xenarthra, Dasypodidae)
    Lorenna C Rezende
    Department of Surgery, Faculty of Veterinary Medicine, University of Sao Paulo, Av Prof Dr Orlando Marques de Paiva, no 87, Cidade Universitaria, Sao Paulo, SPCEP 05508 000, Brazil
    Reprod Biol Endocrinol 10:38. 2012
    ..Placental characters vary among Xenarthra, one of four supraordinal clades of Eutheria. Armadillos are known for villous, haemochorial placentas similar to humans. Only the nine-banded armadillo has been well studied so far...
  73. ncbi Placentation in the African elephant, Loxodonta africana. IV. Growth and function of the fetal gonads
    W R Allen
    University of Cambridge, Department of Veterinary Medicine Equine Fertility Unit, Mertoun Paddocks, Woodditton Road, Newmarket, Suffolk CB8 9BH, UK
    Reproduction 130:713-20. 2005
    ....
  74. ncbi Evolution of the placenta during the early radiation of placental mammals
    Andrea Mess
    Museum of Natural History, Department of Research, Humboldt University Berlin, Invalidenstr 43, DE 10115 Berlin, Germany
    Comp Biochem Physiol A Mol Integr Physiol 148:769-79. 2007
    ..We show that epitheliochorial placentation, the least invasive type, is a derived state and discuss factors that may have determined its evolution with ..
  75. ncbi Imprinted genes, placental development and fetal growth
    A L Fowden
    Department of Physiology, Cambridge, UK
    Horm Res 65:50-8. 2006
    ....
  76. ncbi hCG and hyperglycosylated hCG in the establishment and evolution of hemochorial placentation
    Laurence A Cole
    USA hCG Reference Service Reference Service, Women s Health Research, Department of Obstetrics and Gynecology, University of New Mexico, Albuquerque, NM 87131, USA
    J Reprod Immunol 82:112-8. 2009
    ..of regular chorionic gonadotropin (CG) and hyperglycosylated CG are linked with the evolution of hemochorial placentation in primates...
  77. ncbi Vascular biology in implantation and placentation
    Berthold Huppertz
    Department of Anatomy II, University Hospital RWTH Aachen, Aachen, Germany
    Angiogenesis 8:157-67. 2005
    ..This review tries to cover all the above-mentioned topics and will try to depict the consequences of poor placentation on mother and fetus.
  78. pmc Reduced maternal expression of adrenomedullin disrupts fertility, placentation, and fetal growth in mice
    Manyu Li
    Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Clin Invest 116:2653-62. 2006
    ..to implicate both maternal and, to a lesser extent, embryonic levels of AM in the processes of implantation, placentation, and subsequent fetal growth...
  79. ncbi HtrA3, a serine protease possessing an IGF-binding domain, is selectively expressed at the maternal-fetal interface during placentation in the mouse
    G Nie
    Prince Henry s Institute of Medical Research, PO Box 5152, 246 Clayton Road, Clayton, Victoria 3168, Australia
    Placenta 27:491-501. 2006
    Hemochorial placentation involves highly regulated interactions between fetal- and maternal-derived cells...
  80. pmc Chromosome-substituted rat strains provide insights into the genetics of placentation
    Toshihiro Konno
    Institute for Reproductive Health and Regenerative Medicine and Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Physiol Genomics 43:930-41. 2011
    The rat possesses a hemochorial form of placentation. Pronounced intrauterine trophoblast cell invasion and vascular remodeling characterize this type of placentation. Strain-specific patterns of placentation are evident in the rat...
  81. ncbi Evolution and development of fetal membranes and placentation in amniote vertebrates
    Kirsten Ferner
    Department of Research, Museum für Naturkunde Leibniz Institute for Research on Evolution and Biodiversity at the Humboldt University Berlin, Berlin, Germany
    Respir Physiol Neurobiol 178:39-50. 2011
    We review aspects of fetal membrane evolution and patterns of placentation within amniotes, the most successful land vertebrates. Special reference is given to embryonic gas supply...
  82. ncbi Human placentation from nidation to 5 weeks of gestation. Part II: Tools to model the crucial first days
    J L James
    Department of Obstetrics and Gynecology, University of Auckland, 85 Park Rd, Grafton, Auckland, New Zealand
    Placenta 33:335-42. 2012
    ..and in vitro cell culture models that have been used to study the earliest stages of human implantation and placentation from nidation to 5 weeks of gestation...
  83. pmc Maternal diabetes affects specific extracellular matrix components during placentation
    F R C Giachini
    Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    J Anat 212:31-41. 2008
    ..b>Placentation is probably guided by the composition and organization of the endometrial extracellular matrix...
  84. ncbi Expression of human leukocyte antigen-G during normal placentation and in preeclamptic pregnancies
    Xiaoming Zhu
    Department of Obstetrics and Gynecology, Tangdu Hospital, The Fourth Military Medical University, Xi an, PR China
    Hypertens Pregnancy 31:252-60. 2012
    This study was undertaken to investigate the expression pattern of human leukocyte antigen-G (HLA-G) during normal placentation and determine whether altered expression of HLA-G is associated with severe preeclampsia.
  85. ncbi IFPA Meeting 2010 Workshop Report I: Immunology; ion transport; epigenetics; vascular reactivity; epitheliochorial placentation; proteomics
    C Abad
    Instituto Venezolano de Investigaciones Cientificas, Caracas, Venezuela
    Placenta 32:S81-9. 2011
    ..5. The workshop on epitheliochorial placentation covered current advances from in vivo and in vitro studies of different domestic species. 6...
  86. ncbi Multiple roles for heparin-binding epidermal growth factor-like growth factor are suggested by its cell-specific expression during the human endometrial cycle and early placentation
    R E Leach
    Department of Obstetrics and Gynecology, C S Mott Center for Human Growth and Development, Wayne State University, Detroit, USA
    J Clin Endocrinol Metab 84:3355-63. 1999
    ..These findings suggest that HB-EGF promotes implantation and trophoblast invasion through paracrine and autocrine signaling as cells penetrate the stroma and displace the arteriole endothelium...
  87. ncbi IGF-I Overexpression causes fetal loss during placentation in mice
    Orie Nakamura
    Department of Veterinary Anatomy, Faculty of Agriculture, Yamaguchi University
    J Reprod Dev 50:375-80. 2004
    ..Thus, it is likely that IGF-I plays a role in the decidual formation through regulation of uNK cells. This is the first report to demonstrate that IGF-I overexpression can cause fetal loss during murine placentation.
  88. pmc Cytomegalovirus impairs cytotrophoblast-induced lymphangiogenesis and vascular remodeling in an in vivo human placentation model
    Takako Tabata
    Department of Cell and Tissue Biology, School of Dentistry, University of California, San Francisco, USA
    Am J Pathol 181:1540-59. 2012
    ..In this in vivo human placentation model, human cytotrophoblasts invade the renal parenchyma, remodel resident arteries, and induce a robust ..
  89. ncbi Trophoblast invasion and placentation: molecular mechanisms and regulation
    Frédéric van den Brûle
    Laboratory of Tumor Biology and Development, Pathology B23, CHU Liege, Liege, Belgium
    Chem Immunol Allergy 88:163-80. 2005
    Trophoblast invasion is a key process during human placentation. This event constitutes the basis of the conversion of the uterine spiral arteries, a process which allows an adequate vascular connection between the intervillous space and ..
  90. ncbi Polymorphism A1/A2 in the cell surface integrin subunit β3 and disturbance of implantation and placentation in women with recurrent pregnancy loss
    Petar D Ivanov
    Department of Chemistry and Biochemistry, University of Medicine, Pleven, Bulgaria
    Fertil Steril 94:2843-5. 2010
    ..3% versus 16.4% in controls), but it was much more pronounced in 67 women with RPL between 10 and 20 weeks of gestation (41.8%), illustrating its role in recurrent fetal loss...
  91. ncbi Comparative studies of placentation and immunology in non-human primates suggest a scenario for the evolution of deep trophoblast invasion and an explanation for human pregnancy disorders
    Anthony M Carter
    Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, J B Winsloewsvej 21, DK 5000 Odense, Denmark
    Reproduction 141:391-6. 2011
    ..The fetal genotype is in part derived from the father providing an explanation for the paternal contribution to reproductive disorders...
  92. ncbi Placental expression of angiopoietin-1, angiopoietin-2 and tie-2 during placental development in an ovine model of placental insufficiency-fetal growth restriction
    Amy S Erickson Hagen
    Department of Biomedical Sciences, Colorado State University, Fort Collins 80523, USA
    Pediatr Res 58:1228-32. 2005
    ..b>Placentation requires extensive vasculogenesis and subsequent angiogenesis, in both maternal and fetal tissues...
  93. ncbi Placental development during early pregnancy in sheep: vascular growth and expression of angiogenic factors in maternal placenta
    Anna T Grazul-Bilska
    Department of Animal Science, Center for Nutrition and Pregnancy, Cell Biology Center, North Dakota State University, Fargo, North Dakota 58105, USA
    Reproduction 140:165-74. 2010
    ..This more complete description of early placental angiogenesis may provide the foundation for determining whether placental vascular development is altered in compromised pregnancies...
  94. pmc The chemokine receptor CXCR4 and its ligand CXCL12 are activated during implantation and placentation in sheep
    Ryan L Ashley
    Department of Animal and Range Sciences, New Mexico State University, Las Cruces, New Mexico, USA
    Reprod Biol Endocrinol 9:148. 2011
    The progression of implantation and placentation in ruminants is complex and is regulated by interplay between sex steroids and local signaling molecules, many of which have immune function...
  95. ncbi Defective placentation and resultant oxidative stress play a similar role in complete hydatidiform mole to that in preeclampsia and early pregnancy loss
    Muge Harma
    Department of Obstetrics and Gynecology, Medical School, Harran University, Sanliurfa, Turkey
    Med Hypotheses 66:100-2. 2006
    Defective placentation and resultant oxidative stress are believed to be largely responsible for preeclampsia and early pregnancy loss...
  96. ncbi Mice deficient in heparan sulfate 6-O-sulfotransferase-1 exhibit defective heparan sulfate biosynthesis, abnormal placentation, and late embryonic lethality
    Hiroko Habuchi
    Institute for Molecular Science of Medicine and Laboratory Animal Research Center, Aichi Medical University, Nagakute, Aichi 480 1195, Japan
    J Biol Chem 282:15578-88. 2007
    ..Thus, despite the presence of three closely related 6-O-sulfotransferase genes in the mouse genome, HS6ST-1 is the primary one used in HS biosynthesis in most tissues...
  97. ncbi Evolution of the interhaemal barrier in the placenta of rodents
    A M Mess
    Department of Research, Museum of Natural History, Leibniz Community, Berlin, Germany
    Placenta 30:914-8. 2009
    ..In contrast the second clade shows multiple character transformations...
  98. ncbi Defective deep placentation
    Yee Khong
    SA Pathology, North Adelaide 5006, Australia
    Best Pract Res Clin Obstet Gynaecol 25:301-11. 2011
    Defective deep placentation is characterised by defective remodelling of the utero-placental arteries...
  99. ncbi Type 2 cadherins in the human endometrium and placenta: their putative roles in human implantation and placentation
    C D MacCalman
    Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, Canada
    Am J Reprod Immunol 39:96-107. 1998
    ..The cadherins are a gene superfamily of calcium-dependent cell adhesion molecules. To date, the role(s) of the cadherins in human implantation remains poorly defined...
  100. ncbi Trophoblast glycogen cells differentiate early in the mouse ectoplacental cone: putative role during placentation
    Renato Borges Tesser
    Department of Histology and Structural Biology, Medical School of the Federal University of São Paulo, Sao Paulo, SP, Brazil
    Histochem Cell Biol 134:83-92. 2010
    ..of mouse GCs in EPC and their relationship with blood cells and trophoblast giant cells (TGCs) during placentation. Implantation sites (E5.5-E12...
  101. ncbi Decidual NK cells alter in vitro first trimester extravillous cytotrophoblast migration: a role for IFN-gamma
    Yuxiang Hu
    Department of Obstetrics and Gynaecology, University of British Columbia, 2H30 4500 Oak Street, Vancouver, BC, Canada
    J Immunol 177:8522-30. 2006
    Abnormal placentation results in either inadequate (consequences: recurrent miscarriage, intrauterine growth restriction, and preeclampsia) or overzealous (consequences: placenta accreta, increta, and percreta) placentation...

Research Grants74

  1. Predictors of Pregnancy Outcome in SLE and APS
    Jane E Salmon; Fiscal Year: 2012
    ....
  2. Integrin Regulation of Stretch-Activated Myometrial Signaling During Pregnancy an
    Heather R Burkin; Fiscal Year: 2012
    ..Defining the integrin- mediated signaling pathways that regulate stretch induced activation of the uterine myometrium will have important implications for treating preterm and post term labor. ..
  3. Integrin Regulation of Stretch-Activated Myometrial Signaling During Pregnancy an
    Heather R Burkin; Fiscal Year: 2013
    ..Defining the integrin- mediated signaling pathways that regulate stretch induced activation of the uterine myometrium will have important implications for treating preterm and post term labor. ..
  4. Apoptosis and Trophoblast Fusion
    NEAL STEWART ROTE; Fiscal Year: 2010
    ..Defective placentation may result from exogenous environmental or maternal factors or from inborn genetic anomalies...
  5. Pluripotent Stem Cells: Modeling syncytiotrophoblast development and pathogenesis
    Danny J Schust; Fiscal Year: 2013
    ..models of early placental development are essential if we are to better understand and treat diseases of poor placentation. The first goal of this proposal is to generate STB and its mononucleated precursors from human embryonic stem ..
  6. Trophoblast MHC-I: Trigger for Immune-Mediated Rejection of Cloned Bovine Fetuses
    Kenneth L White; Fiscal Year: 2011
    ..Both spontaneous abortion and preeclampsia, which is associated with abnormal placentation, occur at increased frequency in human and bovine pregnancies established by assisted reproductive technologies ..
  7. Role of the Renin-Angiotensin system in placental insufficiency
    Eugenia Mata-Greenwood; Fiscal Year: 2013
    ..In addition, the outcomes of this proposal will shed light into the role of RAS genetics in pregnancy outcomes and will provide the scientific community with a novel animal model to study the genetics of placental insufficiency and PE. ..
  8. The Effects of Ethanol on Microtubules during Mouse Pre-implantation Development
    Yixian Zheng; Fiscal Year: 2012
    ..will allow us to establish a specific mechanism for the ethanol-induced impairment of implantation and placentation. PUBLIC HEALTH RELEVANCE: Fetal Alcohol Spectrum Disorders affects as many as 9 out of 1,000 pregnancies in the ..
  9. Angiogenic factors, abnormal placentation and adverse pregnancy outcomes
    Sarosh Rana; Fiscal Year: 2013
    ..The significance and role of these proteins in normal pregnancy and placentation is not known...
  10. Role of SATB in placental development
    Mohammad A K Rumi; Fiscal Year: 2013
    ..Revealing the fundamental regulators of TS cells will greatly expand our understanding of placental morphogenesis and the pathophysiology of placenta-associated disorders. ..
  11. Adverse Outcomes of Assisted Reproductive Technologies: Genetics or Epigenetics?
    Margareta Pisarska; Fiscal Year: 2013
    ..placenta previa, preterm delivery, and perinatal mortality, many of which may be attributed to abnormalities of placentation and trophoblast differentiation in the first trimester, and also have increased risks for major structural ..
  12. Fetal HCMV Infection: Role of the Human Placenta
    LENORE PALMA PEREIRA; Fiscal Year: 2013
    ..To study the molecular mechanisms in vivo, we developed a novel model of human placentation in which xenografts of human placental villi (fetal) and decidua (maternal) are implanted in severe-combined ..
  13. Modeling preeclampsia in mice with inducible placenta-specific gene expression
    Nihar R Nayak; Fiscal Year: 2012
    ....
  14. Placental shape features, gestational timing and maternal and infant health
    Carolyn M Salafia; Fiscal Year: 2011
    ....
  15. Role of Maternal Platelets in the Placenta and Pregnancy Complications
    Rashmi Sood; Fiscal Year: 2013
    ..These are much-needed investigations into platelet and coagulation activities at the feto-maternal interface with direct significance for pregnancy disorders. ..
  16. Effects of fetal bisphenol A exposure on mouse epigenome
    Martha Susiarjo; Fiscal Year: 2013
    ..The mouse will be used as a model system in the proposed studies to determine the potential etiology of human diseases with underlying environmental causes. ..
  17. The Viral Life Cycle of Human Endogenous Retrovirus Type K
    Derek Dube; Fiscal Year: 2013
    ..abstract_text> ..
  18. Fetal Programming and Environmental Exposures: Implications for Prenatal Care and
    Jeffrey A Whitsett; Fiscal Year: 2012
    ..effect on the trajectory of prenatal development and pre-term birth, including the effects on: implantation;placentation;organogenesis;and neonatal health, and how to combat these effects;(ii) foster and highlight the research ..
  19. The role of CEACAM1 in CMV pathogenesis in the human placenta
    Takako Tabata; Fiscal Year: 2012
    ..This project addresses molecular mechanisms of viral damage that impairs functions of the human placenta and could identify novel proteins with clinical importance for development of diagnostic and therapeutic strategies. ..
  20. Human Cytomegalovirus-Induced Inhibition of Cytotrophoblast Invasion
    CINDY ANNE MORRIS; Fiscal Year: 2012
    ..during early first trimester pregnancy resulting in impaired remodeling of maternal spiral arteries and shallow placentation. Preliminary studies demonstrate that HCMV infection of first trimester EVT results in inhibition of EVT ..
  21. Incorporation of Endothelial Progenitor Cells into Placental Vaculature
    Greg A Johnson; Fiscal Year: 2013
    ....
  22. GATA Factor Function in Trophoblast
    Soumen Paul; Fiscal Year: 2013
    ..We will also determine whether GATA3 have differentiation stage specific target genes. ..
  23. STUDIES OF UTEROPLACENTAL CIRCULATION
    CHARLES RICHARD ROSENFELD; Fiscal Year: 2013
    ..the ovarian cycle, contributing to the rise in UBF and the increased likelihood of successful implantation and placentation;2) what is the pattern of BKCa expression in the fetal umbilicoplacental circulation during pregnancy and does ..
  24. Molecular and Cellular Controls of Placental Metabolism
    Yoel Sadovsky; Fiscal Year: 2013
    ..Our findings may pave the way to clinical research into disease biomarkers, therapeutics and prevention. ..
  25. Therapeutic Antibodies for CMV
    WILLIAM ROBERT USINGER; Fiscal Year: 2013
    ..The final deliverable from this project will be an IND-ready native human therapeutic antibody to HCMV, which is highly effective at preventing infection of all relevant cell types by a broad range of HCMV strains. ..
  26. The Function of the Mia3 Gene in Murine Placentation
    Ann E Sutherland; Fiscal Year: 2012
    ....
  27. Preterm Birth in Nulliparous Women: An Understudied Population at Great Risk
    Robert M Silver; Fiscal Year: 2013
    ..The Nulliparous Network offers an opportunity to address these health disparities. ..
  28. Placental morphology and serum biomarkers to predict adverse pregnancy outcome
    Nadav Schwartz; Fiscal Year: 2013
    ....
  29. FLOW EFFECTS ON ENDOTHELIAL/TROPHOBLAST INTERACTION
    Gordon C Douglas; Fiscal Year: 2013
    ..Aim 4 determines whether MUC1 modulates ER function by regulating the intracellular localization of ERs. The final aim uses an optical trap to determine whether cell surface MUC1 responds to directly applied force. ..
  30. ACE2 Deficiency: A new model of maternal and fetal growth restriction.
    Liliya M Yamaleyeva; Fiscal Year: 2013
    ..the presence of ACE2 in human placenta and maternal stromal tissue in normal pregnancy suggesting its role in placentation in established pregnancy...
  31. ERV3 Control of Human Placentation
    NEAL STEWART ROTE; Fiscal Year: 2013
    ..Activation of the [unreadable]-hCG promoter may occur secondary to cAMP-dependent transcription factors or directly if ERV3 Env is a transcription factor. Studies will evaluate both potential processes. ..
  32. FUNCTIONS OF PREGNANCY SPECIFIC GLYCOPROTEINS
    Gabriela S Dveksler; Fiscal Year: 2010
    ..Psg-like proteins are only found in species with hemochorial placentation, in which the maternal blood is in direct contact with fetal tissues...
  33. Integrating Environmental Cues at the Maternal-Fetal Vascular Interface
    Emin Maltepe; Fiscal Year: 2013
    ..and a human placenta tissue bank to test the hypothesis that atypical HIF-target genes regulate mouse and human placentation, and that this process is disrupted in PE...
  34. Adrenomedullin Signaling at the Maternal-Fetal Interface
    Kathleen M Caron; Fiscal Year: 2013
    ..both maternal and fetal sources of AM signaling are important for orchestrating appropriate implantation and placentation that are required for normal fetal growth...
  35. Origins and Biological Consequences of Human Infertility
    Linda C Giudice; Fiscal Year: 2013
    ..abstract_text> ..
  36. A Novel Model for Assessing the Effects of BPA Exposures on Human Placentation
    Susan J Fisher; Fiscal Year: 2013
    ..Similarly, studies in animals suggest that this environmental chemical disrupts placentation, which results in impaired intrauterine growth...
  37. Effects of Xenobiotics on CYP26 Activity and Retinoic Acid Homeostasis
    Nina Isoherranen; Fiscal Year: 2012
    ..This proposal aims at characterizing interactions between xenobiotics and retinoic acid metabolizing CYP26 enzymes that alter retinoic acid metabolism and clearance and can lead to adverse effects. ..
  38. Regulation of Trophoblast Proliferation and Invasion by Pluripotency Factor LIN28
    QUINTON ALEXANDER WINGER; Fiscal Year: 2012
    ..gene regulatory mechanism, LIN28, in trophoblast cells to determine if disrupted regulation produces defective placentation and poor trophoblast invasion...
  39. Prepregnancy Phenotype and Predisposition to Preeclampsia
    IRA MARK BERNSTEIN; Fiscal Year: 2013
    ..In contrast to the view that abnormal placentation results in the release of one or more placental toxins leading to maternal endothelial injury and systemic ..
  40. The Genomic and Functional Consequences of Trophoblast Aneuploidy
    Y KATHERINE BIANCO; Fiscal Year: 2013
    ..Dr. Fisher's group studies human placentation and stem cell biology. In her proposed mentor's lab, Dr...
  41. Preterm Birth in Nulliparous Women: An Understudied Population at Great Risk
    Hyagriv N Simhan; Fiscal Year: 2013
    ..Because nulliparas are a large proportion of pregnant women, understanding the mechanism for future prevention of preterm birth and other related adverse pregnancy outcomes will have a significant public health impact. ..
  42. Dynamic contrast-enhanced MRI of placental circulation
    Antonio Frias; Fiscal Year: 2013
    ....
  43. Prenatal Smoking, Maternal &Fetal Genetic Variation &Risk of Preeclampsia
    Stephanie M Engel; Fiscal Year: 2012
    ..by applicant): The etiology of preeclampsia remains unknown, but is hypothesized to result from abnormal placentation. One of the most common complications of pregnancy, with US incidence rates between 2 per cent and 7 per cent ..
  44. Mechanisms of Preeclampsia: Impact of Obesity
    Carl A Hubel; Fiscal Year: 2012
    ..ADMA;an endogenous inhibitor of nitric oxide synthase) is also the milieu we suggest interacts with poor placentation to promote the endothelial dysfunction of PE...
  45. HIF-1 Alpha Regulation of Trophoblast Differentiation in Vivo
    Thomas L Brown; Fiscal Year: 2013
    ..Understanding how oxygen sensing regulators control normal placental development will help us understand how pregnancy-associated disorders arise, can be detected, and treated. ..
  46. The Role of Leptin in Placental Development
    Laura Clamon Schulz; Fiscal Year: 2011
    ..abstract_text> ..
  47. GENETIC COMPLEMENTATION OF A MOUSE MODEL FOR PWS
    James L Resnick; Fiscal Year: 2010
    ..We anticipate that this research will significantly contribute to understanding the roles of individual genes in complex PWS traits, refine mouse models of the disease, and provide new insights into growth and obesity. ..
  48. A longitudinal study of loss of imprinting in the placenta
    Ronald Wapner; Fiscal Year: 2012
    ..of these obstetrical disorders have their origins in an early intrauterine environment associated with aberrant placentation and trophoblast invasion...
  49. Preterm Delivery and Maternal Cardiovascular Disease Risk
    Claudia B Holzman; Fiscal Year: 2013
    ..to CVD and that inflammation, dyslipidemia and thrombogenesis converge in pregnancy to compromise placentation and/or maternal vascular integrity among a subset of women who deliver preterm...
  50. Novel Ubiquitin Dependent Pathways Regulating Neural Tube Closure &Placentation
    Irene E Zohn; Fiscal Year: 2013
    ..We identified a novel ubiquitin ligase that plays a critical role in neural tube closure and placentation. Our goal is to understand how regulation of protein function by this novel ubiquitin ligase regulates ..
  51. A Primate In Vitro Implantation Model
    Thaddeus Golos; Fiscal Year: 2009
    ..The development of new models with which we can investigate the early formation of the human placenta will be a major step in improving maternal-fetal health. ..
  52. Use of OET to assess mouse preimplantation quality for uterine transfer
    MAURICE MARCEL GARCIA; Fiscal Year: 2013
    ....
  53. Embryotropic actions of follistatin: mechanisms and translational relevance
    George W Smith; Fiscal Year: 2013
    ....
  54. TROPHOBLAST DIFFERENTIATION
    Michael J Soares; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Hemochorial placentation occurs in many mammalian species including primates and rodents...
  55. Aspen Perinatal Biology Conference
    Loren P Thompson; Fiscal Year: 2010
    ....
  56. Maternal Genetic Variation and Risk of Adverse Pregnancy Outcomes
    Stephanie M Engel; Fiscal Year: 2010
    ..The priority pathways we have identified bear relevance to the period of placentation, which is a period of development at which these outcomes may be etiologically linked...
  57. Sirt1-PPARgamma signaling in placental development and fetal growth disorders
    Mana M Parast; Fiscal Year: 2013
    ..growth has been associated with disorders of trophoblastic differentiation and function during early events in placentation, which lead to chronic feto-placental hypoxia...
  58. Predictors of Dietary Quality in Low-Income Pregnant Women
    Eileen R Fowles; Fiscal Year: 2010
    ..More effective targeted strategies initiated within this narrow window of time may reduce the number of low birth weight infants and improve obstetrical outcomes. ..
  59. The Colorado Building Interdisciplinary Research Careers in Women's Health Progra
    Nanette F Santoro; Fiscal Year: 2013
    ..Pregnancy: placentation, lactation, fetal/neonatal programming, 2. Immunology/Rheumatology/Inflammation and 3...
  60. A singular opportunity to determine the evolutionary genetics of retroviral invas
    ALFRED LOUIS ROCA; Fiscal Year: 2013
    ..Endogenous retroviruses (ERVs) comprise ca. 8% of the human genome, where they play a role in placentation and in a number of diseases...
  61. Interruption of maternal-fetal transmission of HIV
    Joseph M McCune; Fiscal Year: 2012
    ..in the context of the SIV-infected rhesus macaque, a well-developed model with unique similarities to human placentation and HIV infection...
  62. Localizing Maternal and Fetal Message in Translation of Preeclampsia Candidate Ge
    Sandra A Founds; Fiscal Year: 2013
    ..This impedes our ability to interpret the maternal versus fetal contributions to placentation or pathogenesis...
  63. Transcriptional Control of Human Placental Differentiation
    Stuart Handwerger; Fiscal Year: 2013
    ..new insights into the molecular mechanisms of placental differentiation and the pathogenesis of the defective placentation in preeclampsia and IUGR...
  64. REGULATION OF MHC GENES IN TROPHOBLAST
    DOUGLAS ANTCZAK; Fiscal Year: 1999
    ..Our proposed studies of equine pregnancy are, therefore, likely to shed light on mechanisms that operate in human pregnancy. They may also have relevance to MHC gene regulation in tumor growth and transplantation biology. ..
  65. Dissociating hypoxia from pathology in preeclampsia and*
    Stacy Zamudio; Fiscal Year: 2007
    ..The advantage of this unique in vivo model is an unparalleled potential to elucidate the underlying pathological causes of preeclampsia and/or IUGR while controlling for the effects of placental hypoxia. [unreadable] [unreadable]..
  66. The Role of Leptin in Placental Development
    Laura Schulz; Fiscal Year: 2009
    ..Second, this project will increase our understanding of the ways in which maternal nutrition during pregnancy, may influence placental development, and even adult health.; ..
  67. Primate Endometrial Responses to Placental MHC Class I Molecules
    Thaddeus Golos; Fiscal Year: 2009
    ....
  68. Misregulation of apoptosis in cloned pig embryos
    Heide Schatten; Fiscal Year: 2007
    ..Insufficient placentation is the primary cause for cloned fetal loss...
  69. Trophoblast Selectins and Their Uterine Mucin Ligands
    Susan Fisher; Fiscal Year: 2006
    ..adhere to and then invade the uterine wall is an integral component first of implantation and subsequently of placentation We have a longstanding interest in the adhesive properties of the human mononuclear Tbs, termed ..
  70. IMMUNE TROPHOBLAST INJURY
    Keith McCrae; Fiscal Year: 1992
    ..and preeclampsia--three diseases in which deficient trophoblast-mediated PA activity may result in inadequate placentation and subsequent placental ischemia. Finally, Dr...
  71. Novel 3-D Model of Placental Cytomegalovirus Infection
    Cindy Morris; Fiscal Year: 2006
    ..maternal-fetal interface during pregnancy, and 4) the molecular mechanism(s) that regulate the effect of CMV on placentation and pregnancy outcome...
  72. Mechanisms of Arsenic Toxicity in Vascular Development
    J Douglas Coffin; Fiscal Year: 2003
    ..deformations and developmental anomalies in other systems and vascular abnormalities often form the basis for placentation defects linked to miscarriage...
  73. Gap Junctions in Placental Development
    Stephen Lye; Fiscal Year: 2004
    ..This novel investigation integrates the experience and efforts of three laboratories, each recognized internationally for their independent investigations on placental development. ..
  74. Transcriptional Control of Placental Development
    Yaacov Barak; Fiscal Year: 2007
    ..These aims will provide valuable insights into the regulation of developmental processes in the placenta, improving our understanding of health and disease processes of the fetus and the pregnant mother. ..