cervical ripening

Summary

Summary: A change in the CERVIX UTERI with respect to its readiness to relax. The cervix normally becomes softer, more flexible, more distensible, and shorter in the final weeks of PREGNANCY. These cervical changes can also be chemically induced (LABOR, INDUCED).

Top Publications

  1. ncbi Outpatient misoprostol compared with dinoprostone gel for preinduction cervical ripening: a randomized controlled trial
    Marjorie Meyer
    University of Vermont, Burlington, USA
    Obstet Gynecol 105:466-72. 2005
  2. pmc Progesterone withdrawal promotes remodeling processes in the nonpregnant mouse cervix
    Steven M Yellon
    Department of Physiology, Loma Linda University School of Medicine, Loma Linda, California, USA
    Biol Reprod 81:1-6. 2009
  3. ncbi A clinical evaluation of controlled-release dinoprostone for cervical ripening--a review of current evidence in hospital and outpatient settings
    Werner Rath
    Department Obstetrics and Gynecology, University of Aachen, Germany
    J Perinat Med 33:491-9. 2005
  4. ncbi The effect of orally and vaginally administered misoprostol on inflammatory mediators and cervical ripening during early pregnancy
    Annette Aronsson
    Department of Woman and Child Health, Division for Obstetrics and Gynecology, Karolinska Institute, S 171 76 Stockholm, Sweden
    Contraception 72:33-9. 2005
  5. ncbi [Cervical Foley catheter versus vaginal misoprostol for cervical ripening and induction of labor: a randomized clinical trial]
    Maria Virginia de Oliveira e Oliveira
    Maternidade Escola de Vila Nova Cachoeirinha Dr Mário de Moraes Altenfelder Silva, Sao Paulo, SP, Brasil
    Rev Bras Ginecol Obstet 32:346-51. 2010
  6. ncbi [Clinical study on dinoprostone suppositories 0.8 mm used in cervical ripening and labor induction of women with term pregnancy of premature rupture of the membranes: a multicenter study]
    Li Ying Zou
    Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China
    Zhonghua Fu Chan Ke Za Zhi 45:492-6. 2010
  7. ncbi Mechanical methods of cervical ripening and labor induction
    Shari Gelber
    Drexel University, 245 North 15th Street, MS 495, New College Building, Philadelphia, Pennsylvania 19102, USA
    Clin Obstet Gynecol 49:642-57. 2006
  8. ncbi [Survey of the practice of cervical ripening and labor induction in France]
    F Goffinet
    Maternite Port Royal, Hopital Cochin, 123, boulevard de Port Royal, 75014 Paris
    J Gynecol Obstet Biol Reprod (Paris) 32:638-46. 2003
  9. ncbi Macrophages and not granulocytes are involved in cervical ripening
    Yoshiharu Sakamoto
    School of Surgical and Reproductive Sciences, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, NE2 4HH, UK
    J Reprod Immunol 66:161-73. 2005
  10. ncbi Medical and mechanical methods for cervical ripening
    T Biron-Shental
    Department of Obstetrics and Gynecology, Meir General Hospital, Kfar Saba, Israel
    Int J Gynaecol Obstet 85:159-60. 2004

Research Grants

  1. UTERINE CONTRACTILITY AND CERVICAL RIPENING IN PREGNANCY
    Robert Garfield; Fiscal Year: 2003
  2. PHYSIOLOGY OF HUMAN RELAXIN
    Gerson Weiss; Fiscal Year: 1993
  3. COOPERATIVE MULTICENTER REPRODUCTIVE MEDICINE NETWORK
    PETER MCGOVERN; Fiscal Year: 2004
  4. Female Reproductive Organs and Their Innervation.
    RAYMOND PAPKA; Fiscal Year: 2006
  5. Caspase-3 Maintains Uterine Quiescence in a PR and NF-Kappa B Dependent Manner
    Jennifer C Condon; Fiscal Year: 2010
  6. FEMALE REPRODUCTIVE ORGANS AND THEIR INNERVATION
    RAYMOND PAPKA; Fiscal Year: 2001
  7. Platelet Activating Factor & cervical ripening
    George Saade; Fiscal Year: 2003
  8. Genomic/Proteomic Premature Birth Research Clinical Core
    RADOSLAW BUKOWSKI; Fiscal Year: 2007
  9. Molecular Mechanisms of Parturition
    Mala Mahendroo; Fiscal Year: 2005
  10. Molecular Mechanisms of Parturition
    Mala S Mahendroo; Fiscal Year: 2010

Detail Information

Publications206 found, 100 shown here

  1. ncbi Outpatient misoprostol compared with dinoprostone gel for preinduction cervical ripening: a randomized controlled trial
    Marjorie Meyer
    University of Vermont, Burlington, USA
    Obstet Gynecol 105:466-72. 2005
    ..Despite the numerous trials examining misoprostol for induction, the efficacy of a single outpatient dose of misoprostol followed by oxytocin induction is unknown...
  2. pmc Progesterone withdrawal promotes remodeling processes in the nonpregnant mouse cervix
    Steven M Yellon
    Department of Physiology, Loma Linda University School of Medicine, Loma Linda, California, USA
    Biol Reprod 81:1-6. 2009
    Prepartum cervical ripening is associated with remodeling of collagen structure and with inflammation. Progesterone withdrawal is critical for parturition, but the effects of progesterone decline on cervical morphology are unknown...
  3. ncbi A clinical evaluation of controlled-release dinoprostone for cervical ripening--a review of current evidence in hospital and outpatient settings
    Werner Rath
    Department Obstetrics and Gynecology, University of Aachen, Germany
    J Perinat Med 33:491-9. 2005
    ..Controlled-release dinoprostone, delivered over 24 h from a vaginal insert, results in cervical ripening within 12 h in most women...
  4. ncbi The effect of orally and vaginally administered misoprostol on inflammatory mediators and cervical ripening during early pregnancy
    Annette Aronsson
    Department of Woman and Child Health, Division for Obstetrics and Gynecology, Karolinska Institute, S 171 76 Stockholm, Sweden
    Contraception 72:33-9. 2005
    ..The objective of the present study was to investigate the effect of vaginally and orally administered misoprostol on the local cervical inflammatory response...
  5. ncbi [Cervical Foley catheter versus vaginal misoprostol for cervical ripening and induction of labor: a randomized clinical trial]
    Maria Virginia de Oliveira e Oliveira
    Maternidade Escola de Vila Nova Cachoeirinha Dr Mário de Moraes Altenfelder Silva, Sao Paulo, SP, Brasil
    Rev Bras Ginecol Obstet 32:346-51. 2010
    To compare the effectiveness of the Foley balloon with vaginal misoprostol for cervical ripening and labor induction.
  6. ncbi [Clinical study on dinoprostone suppositories 0.8 mm used in cervical ripening and labor induction of women with term pregnancy of premature rupture of the membranes: a multicenter study]
    Li Ying Zou
    Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China
    Zhonghua Fu Chan Ke Za Zhi 45:492-6. 2010
    To investigate safety and efficacy of dinoprostone suppositories (0.8 mm) used in cervical ripening and labor induction in women with term premature rupture of the membranes.
  7. ncbi Mechanical methods of cervical ripening and labor induction
    Shari Gelber
    Drexel University, 245 North 15th Street, MS 495, New College Building, Philadelphia, Pennsylvania 19102, USA
    Clin Obstet Gynecol 49:642-57. 2006
    This article reviews the safety and efficacy of mechanical agents for cervical ripening. Hygroscopic dilators, balloon catheters, and devices designed for cervical ripening have all been shown to be safe and effective for cervical ..
  8. ncbi [Survey of the practice of cervical ripening and labor induction in France]
    F Goffinet
    Maternite Port Royal, Hopital Cochin, 123, boulevard de Port Royal, 75014 Paris
    J Gynecol Obstet Biol Reprod (Paris) 32:638-46. 2003
    ..survey was to describe current medical practices and procedures in France, regarding labor induction and cervical ripening, eight years after the national consensus on labor induction management...
  9. ncbi Macrophages and not granulocytes are involved in cervical ripening
    Yoshiharu Sakamoto
    School of Surgical and Reproductive Sciences, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, NE2 4HH, UK
    J Reprod Immunol 66:161-73. 2005
    To clarify the role of leucocytes in human cervical ripening and dilatation, cervical biopsies were obtained from six non-pregnant women, eight women undergoing early termination of pregnancy, 18 pregnant women undergoing elective ..
  10. ncbi Medical and mechanical methods for cervical ripening
    T Biron-Shental
    Department of Obstetrics and Gynecology, Meir General Hospital, Kfar Saba, Israel
    Int J Gynaecol Obstet 85:159-60. 2004
  11. ncbi Transcervical Foley catheter for preinduction cervical ripening in an outpatient versus inpatient setting
    A C Sciscione
    Department of Obstetrics and Gynecology, Christiana Care Health Services, Newark, Delaware 19718, USA
    Obstet Gynecol 98:751-6. 2001
    To compare use of the Foley catheter for preinduction cervical ripening in an inpatient versus outpatient setting.
  12. doi Preventing cervical ripening: the primary mechanism by which progestational agents prevent preterm birth?
    Hua Xu
    Center for Research in Reproduction and Women s Health, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA 19104 6142, USA
    Am J Obstet Gynecol 198:314.e1-8. 2008
    ..These studies sought to assess novel pathways by which progestational agents (PAs) may modify signal transduction pathways that are involved in cervical ripening.
  13. pmc Impaired leukocyte influx in cervix of postterm women not responding to prostaglandin priming
    Lena Sahlin
    Division for Reproductive Endocrinology, Q2 08, Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, Sweden
    Reprod Biol Endocrinol 6:36. 2008
    ....
  14. pmc Using a simplified Bishop score to predict vaginal delivery
    S Katherine Laughon
    Epidemiology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
    Obstet Gynecol 117:805-11. 2011
    ..However, it was created without modern statistical methods. Our objective was to determine whether a simplified score can predict vaginal delivery equally well...
  15. ncbi Prostaglandin E2 receptor EP4-selective antagonist inhibits lipopolysaccharide-induced cervical ripening in rabbits
    Yuka Fukuda
    Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Acta Obstet Gynecol Scand 86:1297-302. 2007
    The purpose of this study was to examine whether EP4 as prostaglandin (PG) E2 receptor is involved in lipopolysaccharide (LPS)-induced cervical ripening.
  16. ncbi Endocrine regulation of cervical ripening in humans--potential roles for gonadal steroids and insulin-like growth factor-I
    Gunvor Ekman-Ordeberg
    Department of Woman and Child Health, Divisions for Obstetrics and Gynecology, Karolinska Hospital, SE 171 76 Stockholm, Sweden
    Steroids 68:837-47. 2003
    ..The onset of labor as well as cervical ripening is under hormonal control...
  17. doi Cervical priming in the first trimester: morphological and biochemical effects of misoprostol and isosorbide mononitrate
    Nina Vukas Radulovic
    Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, Gothenburg, Sweden
    Acta Obstet Gynecol Scand 88:43-51. 2009
    ..To evaluate morphological changes and inflammatory events in the uterine cervix following presurgical treatment with the prostaglandin analogue misoprostol or the nitric oxide donor isosorbide mononitrate (IMN)...
  18. doi Induction of labour in nulliparous women with an unfavourable cervix: a randomised controlled trial comparing double and single balloon catheters and PGE2 gel
    C E Pennell
    School of Women s and Infants Health, The University of Western Australia, Crawley, WA, Australia
    BJOG 116:1443-52. 2009
    ..To compare the efficacy and patient satisfaction of three methods of labour induction (double balloon catheters, single balloon catheters and prostaglandin gel) in term nulliparous women with unfavourable cervices...
  19. ncbi Factors affecting the likelihood of successful induction after intravaginal misoprostol application for cervical ripening and labor induction
    Deborah A Wing
    Division of Maternal Fetal Medicine, Department of Obstetrics Gynecology, University of Southern California, Keck School of Medicine, Los Angeles, USA
    Am J Obstet Gynecol 186:1237-40; discussion 1240-3. 2002
    ....
  20. ncbi Sublingual versus vaginal route of misoprostol for cervical ripening prior to surgical termination of first trimester abortions
    Pikee Saxena
    Department of Reproductive Biomedicine, National Institute of Health and Family Welfare, New Mehrauli Road, Munirka, New Delhi 110067, India
    Eur J Obstet Gynecol Reprod Biol 125:109-13. 2006
    ..We conducted this study to compare the effectiveness and acceptability of sublingual versus vaginal route of misoprostol for cervical priming prior to vacuum aspiration (VA)...
  21. ncbi Effects of progesterone on iNOS, COX-2, and collagen expression in the cervix
    Stephen G Marx
    The University of Texas Medical Branch, Department of Obstetrics and Gynecology, Medical Research Bldg 11 104, 301 University Boulevard, Galveston, Texas 77555 106, USA
    J Histochem Cytochem 54:623-39. 2006
    ..relationship between inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in the control of cervical ripening and parturition under normal (normal term pregnancy) and abnormal (preterm labor and prolongation of ..
  22. ncbi High iNOS mRNA and protein levels during early third trimester suggest a role for NO in prelabor cervical ripening in the bovine
    Marian Aalberts
    Department of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands
    Mol Reprod Dev 74:378-85. 2007
    ..These results lead us to suggest that iNOS from spindle shaped cells is involved in prepartum cervical ripening, while iNOS in mononuclear inflammatory cells may be important for local tissue repair mechanisms during ..
  23. ncbi Cervical ripening before operative hysteroscopy in premenopausal women: a randomized, double-blind, placebo-controlled comparison of vaginal and oral misoprostol
    Cem Batukan
    Department of Obstetrics and Gynecology, School of Medicine, Erciyes University, Kayseri, Turkey
    Fertil Steril 89:966-73. 2008
    To compare the effectiveness of oral and vaginal misoprostol for preoperative cervical ripening in premenopausal women before hysteroscopic surgery.
  24. doi A randomised comparison between sublingual, oral and vaginal route of misoprostol for pre-abortion cervical ripening in first-trimester pregnancy termination under local anaesthesia
    Pikee Saxena
    Department of Obstetrics and Gynecology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India
    Aust N Z J Obstet Gynaecol 48:101-6. 2008
    ..To compare efficacy of sublingual (S/L), oral and vaginal routes of misoprostol administration for cervical priming before suction evacuation (SE) under local anaesthesia...
  25. doi The home as an appropriate setting for women undertaking cervical ripening before the induction of labour
    Margaret Reid
    Public Health and Health Policy, Division of Community Based Sciences, University of Glasgow, Glasgow, UK
    Midwifery 27:30-5. 2011
    to explore women's experiences of cervical ripening using isosorbide mononitrate (IMN) in the home as part of the main randomised controlled trial.
  26. doi Controlled fine needle biopsy of the uterine cervix during pregnancy
    Sean M Keeler
    Obstetrics and Gynecology, New York University School of Medicine, New York, NY 10016, USA
    Reprod Sci 18:737-42. 2011
    Cervical sampling could furnish tissue-based information regarding premature cervical ripening and effacement. This report assesses the effect of cervical fine needle biopsy (FNB) in the evaluation of cervical shortening.
  27. pmc Cervical remodeling during pregnancy and parturition
    Brenda Timmons
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75235 9032, USA
    Trends Endocrinol Metab 21:353-61. 2010
    ..Recent advances in our understanding of term and preterm cervical remodeling provide new directions for investigation and compel investigators to reevaluate currently accepted models...
  28. doi Pro-inflammatory and anti-inflammatory cytokines in human preterm and term cervical ripening
    Aurelija Dubicke
    Department of Woman and Child Health, Karolinska Institute, FRH lab C4 U1, KBH, 171 76 Stockholm, Sweden
    J Reprod Immunol 84:176-85. 2010
    b>Cervical ripening is necessary for successful delivery...
  29. pmc Cervical softening during pregnancy: regulated changes in collagen cross-linking and composition of matricellular proteins in the mouse
    Meredith L Akins
    Department of Obstetrics and Gynecology, The Cecil H and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Biol Reprod 84:1053-62. 2011
    ....
  30. ncbi Membrane stripping versus single dose intracervical prostaglandin gel administration for cervical ripening
    V Kaul
    Department of Obstetrics and Gynaecology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Int J Gynaecol Obstet 86:388-9. 2004
  31. ncbi [Dynamic expression of matrix metalloproteinases 2 and 8 in rat cervix]
    Chun Yan Yin
    Department of Obstetrics, Second People s Hospital of Guangdong Province, Guangzhou 510317, China
    Nan Fang Yi Ke Da Xue Xue Bao 29:2205-7. 2009
    To elucidate the relationship between collagen degradation and cervical ripening by detecting dynamic expressions of matrix metalloproteinases 2 (MMP-2) and 8 (MMP-8) in rat cervix.
  32. doi Effects of maternal obesity on duration and outcomes of prostaglandin cervical ripening and labor induction
    Leo Pevzner
    Department of Obstetrics and Gynecology, University of California, Irvine, Orange, California 92868, USA
    Obstet Gynecol 114:1315-21. 2009
    ..To estimate the effect of maternal body mass index (BMI) on progress and outcomes of prostaglandin labor induction...
  33. ncbi The "PRIM" study: a randomized comparison of prostaglandin E2 gel with the nitric oxide donor isosorbide mononitrate for cervical ripening before the induction of labor at term
    Inass Osman
    Division of Developmental Medicine, University of Glasgow, Glasgow Royal Infirmary, United Kingdom
    Am J Obstet Gynecol 194:1012-21. 2006
    The purpose of this study was to compare the efficacy and safety profile of prostaglandin E2 with isosorbide mononitrate for cervical ripening before the induction of labor at term.
  34. doi Foley catheter balloon vs locally applied prostaglandins for cervical ripening and labor induction: a systematic review and metaanalysis
    Zvi Vaknin
    Department of Obstetrics and Gynecology, Assaf Harofeh Medical Center, Zerifin, Israel
    Am J Obstet Gynecol 203:418-29. 2010
    We performed a metaanalysis of publications comparing the efficacy and safety of cervical ripening and labor induction by Foley catheter balloon (FCB) vs locally applied prostaglandins (LAPG) in the third trimester of pregnancy...
  35. ncbi Regulation of hyaluronan expression during cervical ripening
    Kelly J Straach
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Glycobiology 15:55-65. 2005
    ..b>Cervical ripening requires changes in the composition and structure of the extracellular matrix...
  36. doi Outpatient cervical ripening with nitric oxide donor isosorbide mononitrate prior to induction of labor
    Sherif M Habib
    Department of Obstetrics and Gynecology, Ain Shams University, Cairo, Egypt
    Int J Gynaecol Obstet 101:57-61. 2008
    To examine the effectiveness and safety of outpatient vaginal administration of isosorbide mononitrate (IMN) to induce cervical ripening.
  37. pmc The molecular mechanisms of cervical ripening differ between term and preterm birth
    Roxane Holt
    Cecil H and Ida Green Center for Reproductive Biology Sciences, Department of Obstetrics and Gynecology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9032, USA
    Endocrinology 152:1036-46. 2011
    In the current study, the mechanisms of premature cervical ripening in murine models of preterm birth resulting from infection or early progesterone withdrawal were compared with the process of term cervical ripening...
  38. ncbi Cervical ripening with a Foley catheter: the role of pre- and postripening ultrasound examination of the cervix
    Antonella Cromi
    Department of Obstetrics and Gynecology, University of Insubria, Del Ponte Hospital, Varese, Italy
    Am J Obstet Gynecol 196:41.e1-7. 2007
    ..study was to assess sonographic changes in cervical length and posterior cervical angle in women undergoing cervical ripening with an extraamniotic Foley catheter and to determine whether pre- and postripening ultrasound parameters ..
  39. ncbi Timing of neutrophil activation and expression of proinflammatory markers do not support a role for neutrophils in cervical ripening in the mouse
    Brenda C Timmons
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9032, USA
    Biol Reprod 74:236-45. 2006
    ..between wild-type mice and steroid 5alpha-reductase type 1 null mice (Srd5a1-/-), which fail to undergo cervical ripening due to insufficient local progesterone metabolism...
  40. pmc Transection of the pelvic or vagus nerve forestalls ripening of the cervix and delays birth in rats
    Lindsey A Clyde
    Department of Physiology, Pathology, and Human Anatomy, Loma Linda University School of Medicine, Loma Linda, CA, USA
    Biol Reprod 84:587-94. 2011
    ..To discover whether transection of the parasympathetic innervation of the cervix affects cervical ripening in the process of parturition was the objective of the present study...
  41. ncbi Comparison of oral and vaginal misoprostol for cervical ripening before manual vacuum aspiration of first trimester pregnancy under local anesthesia: a randomized placebo-controlled study
    Leyla Cakir
    Family Planning Clinic, SSK Social Security Organization Maternity and Women s Health Training Hospital, 06010 Ankara, Turkey
    Contraception 71:337-42. 2005
    ....
  42. doi The transcriptome of cervical ripening in human pregnancy before the onset of labor at term: identification of novel molecular functions involved in this process
    Sonia S Hassan
    Department of Obstetrics and Gynecology, Wayne State University Hutzel Women s Hospital, Detroit, MI 48201, USA
    J Matern Fetal Neonatal Med 22:1183-93. 2009
    ..The aim of this study was to identify changes in the cervical transcriptome in the human uterine cervix as a function of ripening before the onset of labor...
  43. doi Do mechanical methods of cervical ripening increase infectious morbidity? A systematic review
    Jennifer Heinemann
    Department of Obstetrics and Gynecology University of Florida Health Science Center, Jacksonville, Florida 32209, USA
    Am J Obstet Gynecol 199:177-87; discussion 187-8. 2008
    The purpose of this study was to review systematically randomized controlled trials that were associated with cervical ripening. We identified randomized controlled trials that compared the use of Foley catheter, with or without ..
  44. ncbi Sublingual versus vaginal misoprostol for cervical ripening PRIOR TO manual vacuum aspiration under local anaesthesia: a randomized study
    E Caliskan
    Department of Obstetrics and Gynaecology, Kocaeli University, School of Medicine, Kocaeli, Turkey
    Eur J Contracept Reprod Health Care 12:372-7. 2007
    To compare the effectiveness of sublingual and vaginal misoprostol application for cervical ripening prior to manual vacuum aspiration (MVA) under local anaesthesia for voluntary termination of pregnancy between 7 and 10 weeks of ..
  45. doi Preterm and term cervical ripening in CD1 Mice (Mus musculus): similar or divergent molecular mechanisms?
    Juan M Gonzalez
    Maternal and Child Health Research Program, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Reprod 81:1226-32. 2009
    Premature cervical ripening is believed to contribute to preterm birth (PTB)...
  46. pmc Pharmacologic actions of progestins to inhibit cervical ripening and prevent delivery depend on their properties, the route of administration, and the vehicle
    Ruben J Kuon
    Department of Obstetrics and Gynecology, St Joseph s Hospital and Medical Center, Phoenix, AZ 85004, USA
    Am J Obstet Gynecol 202:455.e1-9. 2010
    ..The purpose of this study was to evaluate cervical changes and delivery at term during pregnancy in rats after various progestin treatments...
  47. ncbi Processes regulating cervical ripening differ from cervical dilation and postpartum repair: insights from gene expression studies
    Brenda C Timmons
    Department of Obstetrics and Gynecology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9032, USA
    Reprod Sci 14:53-62. 2007
    ..In the current study, gene expression patterns unique to cervical ripening as compared with cervical dilation and/or postpartum repair are identified in a mouse model...
  48. ncbi The use of oral misoprostol for pre-abortion cervical priming: a randomised controlled trial of 400 versus 200 microg in first trimester pregnancies
    Kevin S Oppegaard
    Department of Gynaecology, Women and Children s Division, Ulleval University Hospital, Oslo, Norway
    BJOG 111:154-9. 2004
    ..To compare the impact of 200 and 400 microg oral misoprostol on pre-operative cervical priming in both primi- and multigravidae prior to first trimester termination of pregnancy. Pre-operative cervical dilatation and bleeding were assessed...
  49. ncbi Misoprostol for cervical ripening in non-pregnant women: a randomized double-blind controlled trial of oral versus vaginal regimens
    C Choksuchat
    Department of Obstetrics and Gynecology, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand
    Hum Reprod 21:2167-70. 2006
    The objective was to compare the efficacy of oral versus vaginal misoprostol for cervical ripening in non-pregnant women.
  50. doi 17alpha-hydroxy-progesterone effects on cervical proinflammatory agents in women at risk for preterm delivery
    Fabio Facchinetti
    Unit of Obstetrics, Mother Infant Department, University of Modena and Reggio Emilia, Modena, Italy
    Am J Perinatol 25:503-6. 2008
    We evaluated if the inhibitory effect of 17alpha-hydroxyprogesterone caproate (17P) on cervical ripening is mediated by cervical proinflammatory agents...
  51. doi High-mobility group box protein 1 and its signalling receptors in human preterm and term cervix
    Aurelija Dubicke
    Department of Woman and Child Health, Karolinska Institute, Stockholm, Sweden
    J Reprod Immunol 84:86-94. 2010
    ..extranuclear expression of HMGB1 during labor suggests a possible role of HMGB1 during the process of cervical ripening. Changes in expression of mRNAs encoding HMGB1, TLR2 and TLR4 in preterm labor suggest differences in the ..
  52. pmc Does self-administered vaginal misoprostol result in cervical ripening in postmenopausal women after 14 days of pre-treatment with estradiol? Trial protocol for a randomised, placebo-controlled sequential trial
    K S Oppegaard
    Department of Gynaecology, Helse Finnmark, Klinikk Hammerfest, Hammerfest, Norway
    BJOG 115:917-e10. 2008
    ..micrograms of self-administered vaginal misoprostol versus self-administered vaginal placebo on preoperative cervical ripening after pre-treatment with estradiol vaginal tablets at home in postmenopausal women prior to day-care ..
  53. pmc Factors involved in the inflammatory events of cervical ripening in humans
    Ylva Stjernholm-Vladic
    Division for Reproductive Endocrinology, Department of Woman and Child Health, Karolinska Institutet, Stockholm, Sweden
    Reprod Biol Endocrinol 2:74. 2004
    b>Cervical ripening is an inflammatory reaction. The glucocorticoid receptor (GR) mediates glucocorticoid anti-inflammatory reactions, whereas nuclear factor (NF)kappaB is a key pro-inflammatory transcription factor...
  54. ncbi Role of relaxin and estrogen in the control of eosinophilic invasion and collagen remodeling in rat cervical tissue at term
    E H Luque
    Department of Human Physiology, Faculty of Biochemistry and Biological Sciences, Universidad Nacional del Litoral, Santa Fe, Argentina
    Biol Reprod 59:795-800. 1998
    ....
  55. doi Cervicovaginal matrix metalloproteinase-9 and cervical ripening in human term parturition
    Suk Joo Choi
    Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    Eur J Obstet Gynecol Reprod Biol 142:43-7. 2009
    ..To investigate the changes of matrix metalloproteinase-9 (MMP-9) in cervicovaginal fluid during pregnancy and its association with parturition...
  56. ncbi The role of sensory neurons in cervical ripening: effects of estrogen and neuropeptides
    C N Mowa
    Northeastern Ohio Universities College of Medicine, Department of Neurobiology, 4209 State RT 44, P O Box 95, Rootstown, OH 44272, USA
    J Histochem Cytochem 52:1249-58. 2004
    ..Collectively, these findings suggest an interrelationship among estrogen, cervix-related sensory neurons, and local cervical events near term...
  57. ncbi 15-hydroxyprostaglandin dehydrogenase and cyclooxygenase 2 messenger ribonucleic acid expression and immunohistochemical localization in human cervical tissue during term and preterm labor
    Susanne Abelin Törnblom
    Department of Obstetrics and Gynecology, Karolinska Hospital and Karolinska Institute, SE 171 76 Stockholm, Sweden
    J Clin Endocrinol Metab 89:2909-15. 2004
    ..This observation indicates that both preterm and term cervical ripening is associated with decreased degradation of prostaglandins.
  58. ncbi Comparison of self-administered vaginal misoprostol versus placebo for cervical ripening prior to operative hysteroscopy using a sequential trial design
    K S Oppegaard
    Department of Gynaecology, Helse Finnmark, Klinikk Hammerfest, Hammerfest, Norway
    BJOG 114:769, e1-12. 2007
    ..the impact of 1000-microgram self-administered vaginal misoprostol versus self-administered vaginal placebo at home on preoperative cervical ripening in both premenopausal and postmenopausal women prior to outpatient resectoscopy.
  59. doi Cervical ripening and insufficiency: from biochemical and molecular studies to in vivo clinical examination
    Dietmar Schlembach
    Department of Obstetrics and Gynecology, Medical University of Graz, Graz, Austria
    Eur J Obstet Gynecol Reprod Biol 144:S70-6. 2009
    To understand cervical ripening and especially the pathophysiology of cervical insufficiency, it is important to know the cervical composition: the cervix is dominated by fibrous connective tissue, consisting predominantly of Type I ..
  60. ncbi Comparison of extraamniotic Foley catheter and intracervical prostaglandin E gel for preinduction cervical ripening
    Rabindranath Dalui
    Department of Obstetrics and Gynecology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Acta Obstet Gynecol Scand 84:362-7. 2005
    ..Pharmacological preparations are in widespread use for cervical ripening but are not free from side-effects and complications. Mechanical methods, i.e...
  61. ncbi Characterization of vascular endothelial growth factor (VEGF) in the uterine cervix over pregnancy: effects of denervation and implications for cervical ripening
    C N Mowa
    Dept of Neurobiology, Northeastern Ohio Universities College of Medicine, 4209 State RT 44, Rootstown, OH 44272, USA
    J Histochem Cytochem 52:1665-74. 2004
    ..Furthermore, angiogenic and sensory neuronal factors may be important in regulating the dynamic microvasculature in the ripening cervix and may subsequently play a role in cervical ripening and the birth process.
  62. ncbi Misoprostol in gynecology
    Alisa B Goldberg
    Planned Parenthood League of Massachusetts, 1055 Commonwealth Avenue, Boston, MA 02215, USA
    Curr Womens Health Rep 3:475-83. 2003
    ..Solid evidence supports the efficacy of misoprostol for cervical ripening before first-trimester suction curettage abortion, and good evidence supports its use before hysteroscopy in ..
  63. ncbi Platelet-activating factor antagonist WEB-2170 inhibits lipopolysaccharide-induced, but not antiprogestin-induced, preterm cervical ripening in timed-pregnant rats
    Holger Maul
    Department of Obstetrics and Gynecology, Division of Reproductive Sciences, University of Texas Medical Branch, Galveston 77550 1062, USA
    Am J Obstet Gynecol 189:963-7. 2003
    The purpose of this study was to determine whether the platelet-activating factor antagonist WEB-2170 inhibits preterm cervical ripening induced by lipopolysaccharide or by antiprogestin RU 486.
  64. ncbi The parturition defect in steroid 5alpha-reductase type 1 knockout mice is due to impaired cervical ripening
    M S Mahendroo
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235 9032, USA
    Mol Endocrinol 13:981-92. 1999
    ..We conclude that a failure of cervical ripening underlies the parturition defect in mice lacking steroid 5alpha-reductase type 1 and that this enzyme ..
  65. ncbi Local application of platelet-activating factor induces cervical ripening accompanied by infiltration of polymorphonuclear leukocytes in rats
    Holger Maul
    Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77550 1062, USA
    Am J Obstet Gynecol 187:829-33. 2002
    The purpose of this study was to determine the effect of locally applied platelet-activating factor on cervical ripening and leukocyte infiltration...
  66. ncbi Cervical priming with misoprostol prior to transcervical procedures
    C Fiala
    Gynmed Clinic, Vienna, Austria
    Int J Gynaecol Obstet 99:S168-71. 2007
    ..Higher doses or longer intervals do not improve the effect on the cervix. Pain is a frequent side effect, but usually responds well to NSAIDs. Other side effects are rare...
  67. ncbi Cervical length changes during preterm cervical ripening: effects of 17-alpha-hydroxyprogesterone caproate
    Fabio Facchinetti
    Unit of Obstetrics, Mother Infant Department, University of Modena and Reggio Emilia, Reggio Emilia, Italy
    Am J Obstet Gynecol 196:453.e1-4; discussion 421. 2007
    ..The purpose of this study was to evaluate whether 17-alpha-hydroxyprogesterone caproate (17P) treatment affect changes in cervical length...
  68. ncbi Sensory nerves and neuropeptides in uterine cervical ripening
    J J Collins
    Department of Neurobiology and Pharmacology, Northeastern Ohio Universities College of Medicine, Rootstown, OH 44272, USA
    Peptides 23:167-83. 2002
    ..The fundamental processes underlying cervical ripening remain poorly understood...
  69. ncbi Pre-term cervical ripening and labor induction
    Susanne Abelin Tornblöm
    Department of Women and Child Health, Division for Obstetrics and Gynecology, Karolinska Hospital, S 171 76 Stockholm, Sweden
    Eur J Obstet Gynecol Reprod Biol 104:120-3. 2002
    ..To evaluate retrospectively pre-term induction; with Prostaglandin (PG) E(2)-gel and i.v. oxtytocin, respectively...
  70. ncbi Role of cytokines and other inflammatory mediators
    Matthias Winkler
    Department of Obstetrics and Gynecology, University Hospital, Technical University, Aachen, Germany
    BJOG 110:118-23. 2003
    ..and molecular biology, it has not yet been possible to fit the individual biochemical components of cervical ripening and dilatation to a uniform clinical moiety or to uncover any regulatory mechanisms...
  71. ncbi Increased level of matrix metalloproteinases 2 and 9 in the ripening process of the human cervix
    Denis Stygar
    Division for Reproductive Endocrinology, Department of Woman and Child Health, Karolinska Institutet, 17176 Stockholm, Sweden
    Biol Reprod 67:889-94. 2002
    ..An extensive remodeling of the connective tissue prior to parturition, i.e., cervical ripening, requires the presence of proteolytic enzymes...
  72. ncbi Uterine chemokines in reproductive physiology and pathology
    Umit A Kayisli
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06520 8063, USA
    Am J Reprod Immunol 47:213-21. 2002
    ..Chemokines are increasingly recognized as important regulators of uterine function...
  73. ncbi Misoprostol in obstetrics and gynecology
    A Weeks
    University of Liverpool, Liverpool, UK
    Int J Gynaecol Obstet 99:S156-9. 2007
  74. ncbi Misoprostol for women's health: a review
    Kelly Blanchard
    Population Council, Johannesburg, South Africa
    Obstet Gynecol 99:316-32. 2002
    ..To review published literature on misoprostol for women's health indications to provide a synthesis of available information and highlight areas in need of additional research...
  75. ncbi Dynamics of cervical remodeling during pregnancy and parturition: mechanisms and current concepts
    R Ann Word
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9032, USA
    Semin Reprod Med 25:69-79. 2007
    ..Results from studies using serial measurements of cervical length indicate that cervical ripening precedes myometrial contractions of labor by several weeks, suggesting that parturition in women is a ..
  76. ncbi Intracervical Foley catheter balloon vs. prostaglandin in preinduction cervical ripening
    S Niromanesh
    Mirza Kochak Khan Hospital, Medical School, Tehran University of Medical Sciences and Health Services, Tehran, Iran
    Int J Gynaecol Obstet 81:23-7. 2003
    The aim of this study is to compare the effectiveness of the intracervical Foley balloon catheter and 3 mg prostaglandin E(2) tablet(s) in preinduction cervical ripening.
  77. ncbi Dynamic changes in the cervical epithelial tight junction complex and differentiation occur during cervical ripening and parturition
    Brenda C Timmons
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9032, USA
    Endocrinology 148:1278-87. 2007
    ..This study evaluated TJ proteins, as well as markers of epithelial cell differentiation in normal and cervical ripening defective mice to gain insights into how the permeability barrier is regulated during pregnancy and ..
  78. ncbi Cervical ripening: biochemical, molecular, and clinical considerations
    Holger Maul
    Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany
    Clin Obstet Gynecol 49:551-63. 2006
    The physiologic and pathologic changes of the uterine cervix during pregnancy leading to cervical ripening are not well understood though are related to the chief pathology and a commonly performed intervention in obstetrics: Preterm ..
  79. ncbi Matrix metalloproteinase-8 correlates with the cervical ripening process in humans
    Maria B Sennström
    Department of Women and Child Health, Division for Obstetrics and Gynecology, Karolinska Hospital, Karolinska Institute, Stockholm, Sweden
    Acta Obstet Gynecol Scand 82:904-11. 2003
    To determine levels of matrix metalloproteinases MMP-1, -3 and -8 and localize them and the tissue inhibitors of metalloproteinases TIMP-1 and -2 in human cervical tissue during the cervical ripening process.
  80. pmc Hyaluronan and its binding proteins during cervical ripening and parturition: dynamic changes in size, distribution and temporal sequence
    Monika Ruscheinsky
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9032, United States
    Matrix Biol 27:487-97. 2008
    ..These studies suggest that HA has multiple, cell specific functions in the cervix that may include modulation of tissue structure and integrity, epithelial cell migration and differentiation, and inflammatory responses...
  81. ncbi Acupuncture for cervical ripening and induction of labor at term--a randomized controlled trial
    M Rabl
    Department of Obstetrics and Gynecology, University of Vienna, Austria
    Wien Klin Wochenschr 113:942-6. 2001
    The aim of this study was to evaluate whether acupuncture at term can influence cervical ripening, induce labor and thus reduce the need for postdates induction.
  82. ncbi Parturition and recruitment of macrophages in cervix of mice lacking the prostaglandin F receptor
    Steven M Yellon
    Department of Physiology, Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA
    Biol Reprod 78:438-44. 2008
    ..The findings indicate that the prostaglandin F(2alpha) receptor and progesterone withdrawal are a necessary part of the final common pathway for ripening of the cervix and the process of parturition...
  83. ncbi Elective cervical ripening in women beyond the 290th day of pregnancy: a randomized trial comparing 2 dinoprostone preparations
    Fabio Facchinetti
    Unit of Gynecology and Obstetrics, Mother Infant Department, University of Modena and Reggio Emilia, Modena, Italy
    J Reprod Med 52:945-9. 2007
    To determine the better performer among cervical ripening agents for the elective induction of labor.
  84. ncbi Low dose intravaginal misoprostol versus intracervical baloon catheter for pre-induction cervical ripening
    T O Tabowei
    Department of Obstetrics and Gynaecology, Zonal General Hospital, Kwale, Delta State, Nigeria
    East Afr Med J 80:91-4. 2003
    ..The efficacy and safety of low dose misoprostol as a ripening agent compared to the widely used balloon catheter in developing countries is undetermined...
  85. ncbi Comparison of prostaglandin E2 tablets or Foley catheter for labour induction in grand multiparas
    M I Al-Taani
    Department of Obstetrics and Gynaecology, Queen Alia Military Hospital, Royal Medical Services, Amman, Jordan
    East Mediterr Health J 10:547-53. 2004
    ..For grand multiparas, PGE2 vaginal tablets may be preferable for ripening the cervix as well as for labour induction...
  86. ncbi Randomised trial of intravaginal misoprostol and intracervical Foley catheter for cervical ripening and induction of labour
    A T Owolabi
    Department of Obstetrics, Gynaecology and Perinatology, College of Health Sciences, Obafemi Awolowo University, Ile Ife, Nigeria
    J Obstet Gynaecol 25:565-8. 2005
    ..and efficacy of intravaginal misoprostol and an intracervical Foley's balloon catheter for preinduction cervical ripening and labour induction...
  87. ncbi Intravaginal misoprostol versus transcervical Foley catheter in pre-induction cervical ripening
    A O Adeniji
    Department of Obstetrics and Gynaecology, Faculty of Clinical Sciences, College of Health Sciences, Ladoke Akintola University of Technology, Osogbo, Osun State, Nigeria
    Int J Gynaecol Obstet 92:130-2. 2006
  88. ncbi Vaginal misoprostol for cervical ripening at term: comparison of outpatient vs. inpatient administration
    Daniel W Chang
    Departments of Obstetrics and Gynecology, San Juan Regional Medical Center, Farmington, New Mexico 87401 5630, USA
    J Reprod Med 50:735-9. 2005
    To compare outpatient with inpatient misoprostol for preinduction cervical ripening at term.
  89. doi Titrated oral compared with vaginal misoprostol for labor induction: a randomized controlled trial
    Shi Yann Cheng
    Department of Obstetrics, China Medical University Beigang, Hospital, Beigang, Yunlin, China
    Obstet Gynecol 111:119-25. 2008
    ..To compare the efficacy and safety of titrated oral misoprostol and vaginal misoprostol for labor induction...
  90. ncbi Cervical ripening and induction of labor with intravaginal misoprostol and Foley catheter cervical traction
    M Kashanian
    Department of Obstetrics and Gynecology, University of Medical Sciences and Health Services, Akbar Abadi Teaching Hospital, Tehran, Iran
    Int J Gynaecol Obstet 92:79-80. 2006
  91. ncbi Comparison between vaginal misoprostol and cervical dinoprostone for cervical ripening and labor induction
    R Neiger
    Department of Obstetrics and Gynecology, University of Tennessee Medical Center, Knoxville Unit, 1924 Alcoa Hwy, Knoxville, TN 37920, USA
    Tenn Med 94:25-7. 2001
    ..efficacy of intravaginal misoprostol (Cytotec) to intracervical dinoprostone (Prepidil) for pre-induction cervical ripening. METHODS: Sixty-one patients admitted for induction of labor, whose cervices were unfavorable (Bishop score: ..
  92. doi Induction of labour in nulliparous and multiparous women: a UK, multicentre, open-label study of intravaginal misoprostol in comparison with dinoprostone
    A A Calder
    Simpson Centre for Reproductive Health, Royal Infirmary of Edinburgh, Edinburgh, UK
    BJOG 115:1279-88. 2008
    To compare the efficacy and safety of a 25-microgram vaginal tablet of misoprostol (APL202) with dinoprostone (3-mg vaginal tablet) in cervical ripening and labour induction.
  93. ncbi Effectiveness and safety of a new vaginal misoprostol product specifically labeled for cervical ripening and labor induction
    Jose Guilherme Cecatti
    Department of Obstetrics and Gynecology, School of Medical Sciences FCM, University of Campinas, SP, Brazil
    Acta Obstet Gynecol Scand 85:706-11. 2006
    ..in two different formulations: vaginal tablets of 25 microg and one-eighth of a 200-microg oral tablet, also administered intravaginally, for cervical ripening and labor induction of term pregnancies with an indication for that.
  94. ncbi Influence of misoprostol or prostaglandin E(2) for induction of labor on the incidence of pathological CTG tracing: a randomized trial
    Alexandre Megalo
    Department of Obstetrics and Gynecology, Lausanne University Hospital, Rue du Bugnon 30, 1010 Lausanne, Switzerland
    Eur J Obstet Gynecol Reprod Biol 116:34-8. 2004
    To compare the efficacy and safety of misoprostol (prostaglandin E(1) (PGE(1))) with dinoprostone (prostaglandin E(2) (PGE(2))) for third trimester cervical ripening and labor induction.
  95. doi Prospective randomised controlled trial to compare safety and efficacy of intravaginal Misoprostol with intracervical Cerviprime for induction of labour with unfavourable cervix
    K S Krithika
    Department of Obstetrics and Gynaecology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    J Obstet Gynaecol 28:294-7. 2008
    ..59 +/- 5.13 h vs 27.77 +/- 12.71 h. The rate of complications was comparable. Vaginal Misoprostol 25 microg 4-hourly is safe and effective for induction of labour with shorter induction to delivery interval...
  96. ncbi [Vaginal application of misoprostol for labor induction after 36 weeks of pregnancy]
    Zulfo Godinjak
    Ginekolosko akuserska klinika, Klinicki centar Univerziteta u Sarajevu
    Med Arh 61:218-20. 2007
    ..The aim of this study was to confirm efficacy and safety of misoprostol in induction of labour in patients in late pregnancy...
  97. ncbi Bishop score and the outcome of labor induction with misoprostol
    Witold Szczesny
    Department of Obstetrics and Gynaecology, Sykehuset Innlandet Hospital Trust, Norway
    Acta Obstet Gynecol Scand 85:579-82. 2006
    ..The aim of the study was to retrospectively identify possible factors for predicting the outcome of induction with misoprostol...
  98. ncbi Comparison of changes in pre-induction cervical factors' scores following ripening with transcervical foley catheter and intravaginal misoprostol
    A O Adeniji
    Department of Obstetrics and Gynaecology, Faculty of Clinical Sciences, College of Health Sciences, Ladoke Akintola University of Technology, Osogbo, Osun State, Nigeria
    Afr J Med Med Sci 34:377-82. 2005
    The study compares the changes in the cervical factors in pre-induction cervical ripening with both transcervical Foley catheter and Intravaginal Misoprostol...
  99. ncbi Efficacy and safety of six hourly vaginal misoprostol versus intracervical dinoprostone: a randomized controlled trial
    Walid Denguezli
    University Hospital Fattouma Bourguiba, Unit of Obstetrics and Gynaecology, 5000 Monastir, Tunisia
    Arch Gynecol Obstet 276:119-24. 2007
    To compare the efficacy and safety of intravaginal misoprostol versus dinoprostone cervical gel for cervical ripening and labour induction.
  100. ncbi [Pharmacological induction of labour: benefits and risks]
    M Romanelli
    Struttura Complessa di Ostetricia e Ginecologia, Centro di Medicina Perinatale e della Riproduzione, Universita degli Studi di Perugia, Perugia, Italy
    Minerva Ginecol 59:347-55. 2007
    ..In this study we aimed to analyse the results of pharmacological induction of labour through the use of dinoprostone, comparing the intracervical gel (Prepidil 0.5 mg) and the vaginal insert (Propess 10 mg)...
  101. ncbi Intravaginal prostaglandin-E2 for cervical priming and induction of labour
    M I Al-Taani
    Department of Obstetrics and Gynecology, Prince Rashed Ben Al Hassan Hospital, Royal Medical Services, Irbid, Jordan
    East Mediterr Health J 13:855-61. 2007
    ..Intrapartum complications, caesarean section and perinatal deaths showed no statistically significant differences between the groups...

Research Grants75

  1. UTERINE CONTRACTILITY AND CERVICAL RIPENING IN PREGNANCY
    Robert Garfield; Fiscal Year: 2003
    ..The methods are rapid and allow assessment of uterine contractility and cervical ripening. Preliminary studies in rats and humans indicate that uterine and cervical function can be successfully ..
  2. PHYSIOLOGY OF HUMAN RELAXIN
    Gerson Weiss; Fiscal Year: 1993
    ..seen in multiple pregnancies and after some superovulation protocols is a cause of premature cervical ripening and premature labor...
  3. COOPERATIVE MULTICENTER REPRODUCTIVE MEDICINE NETWORK
    PETER MCGOVERN; Fiscal Year: 2004
    ..well as inhibiting TIMP-1 production, all effects which can contribute to increased collagen breakdown and cervical ripening. We plan to develop a method of superovulation which should result in luteal regression, which in turn ..
  4. Female Reproductive Organs and Their Innervation.
    RAYMOND PAPKA; Fiscal Year: 2006
    ..to understand neural mechanisms for integration of uterine cervical information and how these play a role in cervical ripening and parturition (act of giving birth) - particularly as this relates to pre-term or protracted labor, spinal ..
  5. Caspase-3 Maintains Uterine Quiescence in a PR and NF-Kappa B Dependent Manner
    Jennifer C Condon; Fiscal Year: 2010
    ..pregnant uterus for contraction is associated with increased oxytocin receptors, increased gap junctions and cervical ripening. In most mammalian species but not the human a precipitous decline in circulating levels of progesterone (P4)..
  6. FEMALE REPRODUCTIVE ORGANS AND THEIR INNERVATION
    RAYMOND PAPKA; Fiscal Year: 2001
    ..during pregnancy and parturition and 5) determine whether some uterine-related neurons influence the cervical ripening of parturition through release of transmitters that act in neurogenic inflammation...
  7. Platelet Activating Factor & cervical ripening
    George Saade; Fiscal Year: 2003
    b>Cervical ripening is of crucial importance for reproduction in mammals...
  8. Genomic/Proteomic Premature Birth Research Clinical Core
    RADOSLAW BUKOWSKI; Fiscal Year: 2007
    ..expertise in many areas of relevance to the RFA such as molecular mechanisms of uterine contractility and cervical ripening, animal models of preterm labor, infection, vascular physiology, placental function, and fetal growth...
  9. Molecular Mechanisms of Parturition
    Mala Mahendroo; Fiscal Year: 2005
    ..The 5alphaR1KO mice have a defect in cervical ripening. Physiological and molecular studies will be undertaken to dissect the steps leading to cervical remodeling ..
  10. Molecular Mechanisms of Parturition
    Mala S Mahendroo; Fiscal Year: 2010
    ..translational and structural changes that mediate cervical softening, a process that is distinct from cervical ripening. The studies outlined in Specific Aim 3 will clarify our understanding of the role inflammatory processes ..
  11. Molecular Mechanisms of Parturition
    Mala Mahendroo; Fiscal Year: 2007
    ..translational and structural changes that mediate cervical softening, a process that is distinct from cervical ripening. The studies outlined in Specific Aim 3 will clarify our understanding of the role inflammatory processes ..
  12. Assessment of Uterine Contractility and Cervical Ripening During Pregnancy
    Robert Garfield; Fiscal Year: 2009
    ..We have maintained Dr. Gary Hankins, Chief of Division of Maternal-Fetal Medicine, Department of Ob/Gyn, in the project (see Dr. Hankins' letter of support in the Appendix). ..
  13. Assessment of Uterine Contractility and Cervical Ripening During Pregnancy
    Robert Garfield; Fiscal Year: 2007
    ..We have maintained Dr. Gary Hankins, Chief of Division of Maternal-Fetal Medicine, Department of Ob/Gyn, in the project (see Dr. Hankins' letter of support in the Appendix). ..
  14. NEURAL REGULATION OF PREPARTUM CERVICAL RIPENING
    Steven M Yellon; Fiscal Year: 2010
    ..Denervation of specific sensory afferents, but not other neural projections, is proposed to disrupt cervical ripening. A second study will explore the possibility that specific neurotransmitters, as eliminated by chemical ..
  15. NEURAL REGULATION OF PREPARTUM CERVICAL RIPENING
    STEVEN YELLON; Fiscal Year: 2009
    ..Denervation of specific sensory afferents, but not other neural projections, is proposed to disrupt cervical ripening. A second study will explore the possibility that specific neurotransmitters, as eliminated by chemical ..
  16. NEURAL REGULATION OF PREPARTUM CERVICAL RIPENING
    STEVEN YELLON; Fiscal Year: 2009
    ..Denervation of specific sensory afferents, but not other neural projections, is proposed to disrupt cervical ripening. A second study will explore the possibility that specific neurotransmitters, as eliminated by chemical ..
  17. NEUROENDOCRINE/IMMUNE INTERACTIONS: ROLE OF MELATONIN
    STEVEN YELLON; Fiscal Year: 2002
    ....
  18. Cranberry for Prevention of Bacteriuria in Pregnancy
    Deborah Wing; Fiscal Year: 2005
    ..We believe that the data to be gathered from this investigation will support a large, Phase I/ll multi-center trial and an R01 application. ..
  19. Fourth International Conf. on Relaxin & Related Peptides
    ORRIN SHERWOOD; Fiscal Year: 2004
    ..Conference web site: http://www.life.uiuc.edu/relaxin2004/ ..