pregnancy

Summary

Summary: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Top Publications

  1. ncbi Maternal mortality for 181 countries, 1980-2008: a systematic analysis of progress towards Millennium Development Goal 5
    Margaret C Hogan
    Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA 98121, USA
    Lancet 375:1609-23. 2010
  2. ncbi 4 million neonatal deaths: when? Where? Why?
    Joy E Lawn
    Saving Newborn Lives Save the Children USA, and International Perinatal Care Unit, Institute of Child Health, London, Cape Town, South Africa
    Lancet 365:891-900. 2005
  3. ncbi Hyperglycemia and adverse pregnancy outcomes
    Boyd E Metzger
    Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    N Engl J Med 358:1991-2002. 2008
  4. ncbi WHO analysis of causes of maternal death: a systematic review
    Khalid S Khan
    Academic Department of Obstetrics and Gynaecology, University of Birmingham, Birmingham, UK
    Lancet 367:1066-74. 2006
  5. ncbi Strategies for reducing maternal mortality: getting on with what works
    Oona M R Campbell
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    Lancet 368:1284-99. 2006
  6. ncbi Evidence-based, cost-effective interventions: how many newborn babies can we save?
    Gary L Darmstadt
    Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
    Lancet 365:977-88. 2005
  7. ncbi Epidemiology and causes of preterm birth
    Robert L Goldenberg
    Department of Obstetrics and Gynecology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    Lancet 371:75-84. 2008
  8. ncbi Epidemiology and burden of malaria in pregnancy
    Meghna Desai
    Malaria Branch, Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Lancet Infect Dis 7:93-104. 2007
  9. ncbi Countdown to 2015 decade report (2000-10): taking stock of maternal, newborn, and child survival
    Zulfiqar A Bhutta
    Aga Khan University, Karachi, Pakistan
    Lancet 375:2032-44. 2010
  10. ncbi Maternal mortality: who, when, where, and why
    Carine Ronsmans
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    Lancet 368:1189-200. 2006

Detail Information

Publications298 found, 100 shown here

  1. ncbi Maternal mortality for 181 countries, 1980-2008: a systematic analysis of progress towards Millennium Development Goal 5
    Margaret C Hogan
    Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA 98121, USA
    Lancet 375:1609-23. 2010
    ..We assessed levels and trends in maternal mortality for 181 countries...
  2. ncbi 4 million neonatal deaths: when? Where? Why?
    Joy E Lawn
    Saving Newborn Lives Save the Children USA, and International Perinatal Care Unit, Institute of Child Health, London, Cape Town, South Africa
    Lancet 365:891-900. 2005
    ..A similar number are stillborn, and 0.5 million mothers die from pregnancy-related causes...
  3. ncbi Hyperglycemia and adverse pregnancy outcomes
    Boyd E Metzger
    Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    N Engl J Med 358:1991-2002. 2008
    It is controversial whether maternal hyperglycemia less severe than that in diabetes mellitus is associated with increased risks of adverse pregnancy outcomes.
  4. ncbi WHO analysis of causes of maternal death: a systematic review
    Khalid S Khan
    Academic Department of Obstetrics and Gynaecology, University of Birmingham, Birmingham, UK
    Lancet 367:1066-74. 2006
    ..Evidence-based health policies and programmes aiming to reduce maternal deaths need reliable and valid information. We undertook a systematic review to determine the distribution of causes of maternal deaths...
  5. ncbi Strategies for reducing maternal mortality: getting on with what works
    Oona M R Campbell
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    Lancet 368:1284-99. 2006
    ..Further delays in getting on with what works begs questions about the commitment of decision-makers to this goal...
  6. ncbi Evidence-based, cost-effective interventions: how many newborn babies can we save?
    Gary L Darmstadt
    Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
    Lancet 365:977-88. 2005
    ..Simultaneous expansion of clinical care for babies and mothers is essential to achieve the reduction in neonatal deaths needed to meet the Millennium Development Goal for child survival...
  7. ncbi Epidemiology and causes of preterm birth
    Robert L Goldenberg
    Department of Obstetrics and Gynecology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    Lancet 371:75-84. 2008
    ..A short cervical length and a raised cervical-vaginal fetal fibronectin concentration are the strongest predictors of spontaneous preterm birth...
  8. ncbi Epidemiology and burden of malaria in pregnancy
    Meghna Desai
    Malaria Branch, Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Lancet Infect Dis 7:93-104. 2007
    We reviewed evidence of the clinical implications and burden of malaria in pregnancy. Most studies come from sub-Saharan Africa, where approximately 25 million pregnant women are at risk of Plasmodium falciparum infection every year, and ..
  9. ncbi Countdown to 2015 decade report (2000-10): taking stock of maternal, newborn, and child survival
    Zulfiqar A Bhutta
    Aga Khan University, Karachi, Pakistan
    Lancet 375:2032-44. 2010
    ..However, much more can and should be done to address maternal and newborn health and improve coverage of interventions related to family planning, care around childbirth, and case management of childhood illnesses...
  10. ncbi Maternal mortality: who, when, where, and why
    Carine Ronsmans
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    Lancet 368:1189-200. 2006
    The risk of a woman dying as a result of pregnancy or childbirth during her lifetime is about one in six in the poorest parts of the world compared with about one in 30 000 in Northern Europe...
  11. pmc Host remodeling of the gut microbiome and metabolic changes during pregnancy
    Omry Koren
    Department of Microbiology, Cornell University, Ithaca, NY 14853, USA
    Cell 150:470-80. 2012
    Many of the immune and metabolic changes occurring during normal pregnancy also describe metabolic syndrome. Gut microbiota can cause symptoms of metabolic syndrome in nonpregnant hosts...
  12. ncbi Pre-eclampsia
    Baha Sibai
    Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, ML 0526, Cincinnati, OH 45267, USA
    Lancet 365:785-99. 2005
    ..Many interventions to lengthen pregnancy (eg, treatment for mild hypertension, plasma-volume expansion, and corticosteroid use) have a poor evidence base...
  13. ncbi ALSPAC--the Avon Longitudinal Study of Parents and Children. I. Study methodology
    J Golding
    Institute of Child Health, University of Bristol, UK
    Paediatr Perinat Epidemiol 15:74-87. 2001
    ALSPAC (The Avon Longitudinal Study of Parents and Children, formerly the Avon Longitudinal Study of Pregnancy and Childhood) was specifically designed to determine ways in which the individual's genotype combines with environmental ..
  14. ncbi Latest advances in understanding preeclampsia
    Christopher W Redman
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Science 308:1592-4. 2005
    Preeclampsia is a relatively common pregnancy disorder that originates in the placenta and causes variable maternal and fetal problems. In the worst cases, it may threaten the survival of both mother and baby...
  15. ncbi Pre-eclampsia
    Eric A P Steegers
    Department of Obstetrics and Gynaecology, Division of Obstetrics and Prenatal Medicine, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, Netherlands
    Lancet 376:631-44. 2010
    Pre-eclampsia remains a leading cause of maternal and perinatal mortality and morbidity. It is a pregnancy-specific disease characterised by de-novo development of concurrent hypertension and proteinuria, sometimes progressing into a ..
  16. pmc Toxoplasma gondii: from animals to humans
    A M Tenter
    Institut für Parasitologie, Tierarztliche Hochschule Hannover, Bunteweg 17, D 30559, Hannover, Germany
    Int J Parasitol 30:1217-58. 2000
    ..If first contracted during pregnancy, T. gondii may be transmitted vertically by tachyzoites that are passed to the foetus via the placenta...
  17. pmc Still too far to walk: literature review of the determinants of delivery service use
    Sabine Gabrysch
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    BMC Pregnancy Childbirth 9:34. 2009
    ....
  18. ncbi Neonatal, postneonatal, childhood, and under-5 mortality for 187 countries, 1970-2010: a systematic analysis of progress towards Millennium Development Goal 4
    JULIE KNOLL RAJARATNAM
    Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA 98121, USA
    Lancet 375:1988-2008. 2010
    ..In view of policy initiatives and investments made since 2000, it is important to see if there is acceleration towards the MDG 4 target. We assessed levels and trends in child mortality for 187 countries from 1970 to 2010...
  19. ncbi H1N1 2009 influenza virus infection during pregnancy in the USA
    Denise J Jamieson
    National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341 3717, USA
    Lancet 374:451-8. 2009
    ..We summarised cases of infection with pandemic H1N1 virus in pregnant women identified in the USA during the first month of the present outbreak, and deaths associated with this virus during the first 2 months of the outbreak...
  20. pmc Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia
    Sharon E Maynard
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Clin Invest 111:649-58. 2003
    ..These observations suggest that excess circulating sFlt1 contributes to the pathogenesis of preeclampsia...
  21. ncbi What works? Interventions for maternal and child undernutrition and survival
    Zulfiqar A Bhutta
    Aga Khan University, Karachi, Pakistan
    Lancet 371:417-40. 2008
    ..and reduction of disease burden (promotion of handwashing and strategies to reduce the burden of malaria in pregnancy)...
  22. ncbi Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysis
    Leanne Bellamy
    Northwick Park Hospital, London, UK
    Lancet 373:1773-9. 2009
    ..We therefore did a comprehensive systematic review and meta-analysis to assess the strength of association between these conditions and the effect of factors that might modify the risk...
  23. pmc Persistent epigenetic differences associated with prenatal exposure to famine in humans
    Bastiaan T Heijmans
    Departments of Molecular Epidemiology, Medical Statistics, and Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    Proc Natl Acad Sci U S A 105:17046-9. 2008
    ..These data are the first to contribute empirical support for the hypothesis that early-life environmental conditions can cause epigenetic changes in humans that persist throughout life...
  24. ncbi Epigenetic transgenerational actions of endocrine disruptors and male fertility
    Matthew D Anway
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4231, USA
    Science 308:1466-9. 2005
    ..The ability of an environmental factor (for example, endocrine disruptor) to reprogram the germ line and to promote a transgenerational disease state has significant implications for evolutionary biology and disease etiology...
  25. pmc Effect of in utero and early-life conditions on adult health and disease
    Peter D Gluckman
    Liggins Institute, University of Auckland, and National Research Centre for Growth and Development, Auckland, New Zealand
    N Engl J Med 359:61-73. 2008
  26. ncbi Cohort profile: the Norwegian Mother and Child Cohort Study (MoBa)
    Per Magnus
    Division of Epidemiology, The Norwegian Institute of Public Health, Oslo, Norway
    Int J Epidemiol 35:1146-50. 2006
  27. ncbi Self-selection and bias in a large prospective pregnancy cohort in Norway
    Roy M Nilsen
    Department of Public Health and Primary Health Care, University of Bergen, Kalfarveien 31, N 5018 Bergen, Norway
    Paediatr Perinat Epidemiol 23:597-608. 2009
    ..To evaluate potential bias due to self-selection in a large prospective pregnancy cohort in Norway, the authors studied differences in prevalence estimates and association measures between study ..
  28. ncbi Adherence to antiretroviral therapy during and after pregnancy in low-income, middle-income, and high-income countries: a systematic review and meta-analysis
    Jean B Nachega
    Department of International Health, Global Disease Epidemiology and Control Program, Johns Hopkins University Bloomberg School of Public Health, 615N Wolfe Street, Suite W5031, Baltimore, MD21205, USA
    AIDS 26:2039-52. 2012
    To estimate antiretroviral therapy (ART) adherence rates during pregnancy and postpartum in high-income, middle-income, and low-income countries.
  29. ncbi Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring
    Karen A Lillycrop
    Development and Cell Biology, University of Southampton, UK
    J Nutr 135:1382-6. 2005
    ..R; 90 g/kg casein plus 1 mg/kg folic acid), or restricted protein plus 5 mg/kg folic acid (RF) diet throughout pregnancy. Pups were killed 6 d after weaning (n = 10 per group)...
  30. ncbi The burden of malaria in pregnancy in malaria-endemic areas
    R W Steketee
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, Georgia 30333, USA
    Am J Trop Med Hyg 64:28-35. 2001
    ..We estimate that each year 75,000 to 200,000 infant deaths are associated with malaria infection in pregnancy. The failure to apply known effective antimalarial interventions through antenatal programs continues to ..
  31. ncbi Transposon-mediated rewiring of gene regulatory networks contributed to the evolution of pregnancy in mammals
    Vincent J Lynch
    Department of Ecology and Evolutionary Biology and Yale Systems Biology Institute, Yale University, New Haven, Connecticut, USA
    Nat Genet 43:1154-9. 2011
    ..1,532 genes were recruited into endometrial expression in placental mammals, indicating that the evolution of pregnancy was associated with a large-scale rewiring of the gene regulatory network...
  32. ncbi Environmental epigenomics and disease susceptibility
    Randy L Jirtle
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Rev Genet 8:253-62. 2007
    ..Methods are now becoming available to investigate the relevance of these phenomena to human disease...
  33. ncbi Factors affecting the utilization of antenatal care in developing countries: systematic review of the literature
    Bibha Simkhada
    Public Health Department and Dugald Baird Centre, University of Aberdeen, UK
    J Adv Nurs 61:244-60. 2008
    ..This paper is a report of a systematic review to identify and analyse the main factors affecting the utilization of antenatal care in developing countries...
  34. ncbi Reproductive technologies and the risk of birth defects
    Michael J Davies
    Robinson Institute, University of Adelaide, Adelaide, SA, Australia
    N Engl J Med 366:1803-13. 2012
    ..The extent to which birth defects after infertility treatment may be explained by underlying parental factors is uncertain...
  35. ncbi Equity in maternal, newborn, and child health interventions in Countdown to 2015: a retrospective review of survey data from 54 countries
    Aluisio J D Barros
    Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil
    Lancet 379:1225-33. 2012
    ..We assessed how inequalities in maternal, newborn, and child health interventions vary by intervention and country...
  36. ncbi Concise review: isolation and characterization of cells from human term placenta: outcome of the first international Workshop on Placenta Derived Stem Cells
    Ornella Parolini
    Centro di Ricerca E Menni, Fondazione Poliambulanza, Istituto Ospedaliero, Via Bissolati 57, 25124 Brescia, Italy
    Stem Cells 26:300-11. 2008
    ....
  37. ncbi Births: final data for 2009
    Joyce A Martin
    U S Department of Health and Human Services, Division of Vital Statistics, Centers for Disease Control and Prevention, National Center for Health Statistics, Hyattsville, MD 20782, USA
    Natl Vital Stat Rep 60:1-70. 2011
    ..characteristics including age, live-birth order, race and Hispanic origin, marital status, hypertension during pregnancy, attendant at birth, method of delivery, and infant characteristics (period of gestation, birthweight, and ..
  38. ncbi Gestational diabetes and the incidence of type 2 diabetes: a systematic review
    Catherine Kim
    Division of General Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Diabetes Care 25:1862-8. 2002
    ..To examine factors associated with variation in the risk for type 2 diabetes in women with prior gestational diabetes mellitus (GDM)...
  39. ncbi Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase
    P S Danielian
    Department of Molecular and Cellular Biology Harvard University 16 Divinity Avenue, Cambridge Massachusetts 02138 USA
    Curr Biol 8:1323-6. 1998
    ..Induction was ligand dependent, rapid and efficient. The results demonstrate that tamoxifen-inducible recombination can be used to effectively modify gene function in the mouse embryo...
  40. pmc 450K epigenome-wide scan identifies differential DNA methylation in newborns related to maternal smoking during pregnancy
    Bonnie R Joubert
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 120:1425-31. 2012
    ..Maternal smoking is a major risk factor for multiple adverse health outcomes in children, but the underlying mechanisms are unclear...
  41. pmc Epigenetic gene promoter methylation at birth is associated with child's later adiposity
    Keith M Godfrey
    Institute of Developmental Sciences, University of Southampton, Southampton, UK
    Diabetes 60:1528-34. 2011
    ..In animal models, maternal diet alters offspring body composition, accompanied by epigenetic changes in metabolic control genes. Little is known about whether such processes operate in humans...
  42. pmc DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific
    Elmar W Tobi
    Molecular Epidemiology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands
    Hum Mol Genet 18:4046-53. 2009
    ..017). Our data indicate that persistent changes in DNA methylation may be a common consequence of prenatal famine exposure and that these changes depend on the sex of the exposed individual and the gestational timing of the exposure...
  43. ncbi Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse
    Shigemi Hayashi
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Dev Biol 244:305-18. 2002
    ..This inducible Cre system will be a broadly useful tool to modulate gene activity in mouse embryos, adults, and culture systems where temporal control is an important consideration...
  44. ncbi Antidepressant use during pregnancy and childhood autism spectrum disorders
    Lisa A Croen
    Division of Research, Kaiser Permanente Northern California, Oakland, CA 94612, USA
    Arch Gen Psychiatry 68:1104-12. 2011
    ..Use of antidepressant medications during pregnancy also shows a secular increase in recent decades, prompting concerns that prenatal exposure may contribute to ..
  45. ncbi India's Janani Suraksha Yojana, a conditional cash transfer programme to increase births in health facilities: an impact evaluation
    Stephen S Lim
    Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA 98121, USA
    Lancet 375:2009-23. 2010
    ..We independently assessed the effect of JSY on intervention coverage and health outcomes...
  46. ncbi The global impact of pre-eclampsia and eclampsia
    Lelia Duley
    Centre for Epidemiology and Biostatistics, University of Leeds, Bradford, UK
    Semin Perinatol 33:130-7. 2009
    Over half a million women die each year from pregnancy related causes, 99% in low and middle income countries...
  47. pmc Where do poor women in developing countries give birth? A multi-country analysis of demographic and health survey data
    Dominic Montagu
    Global Health Group, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 6:e17155. 2011
    In 2008, over 300,000 women died during pregnancy or childbirth, mostly in poor countries. While there are proven interventions to make childbirth safer, there is uncertainty about the best way to deliver these at large scale...
  48. ncbi DNA sequencing of maternal plasma to detect Down syndrome: an international clinical validation study
    Glenn E Palomaki
    Division of Medical Screening and Special Testing, Department of Pathology and Laboratory Medicine, Women and Infants Hospital, Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA
    Genet Med 13:913-20. 2011
    ..Prenatal screening for Down syndrome has improved, but the number of resulting invasive diagnostic procedures remains problematic. Measurement of circulating cell-free DNA in maternal plasma might offer improvement...
  49. ncbi Maternal and child health in Brazil: progress and challenges
    Cesar G Victora
    Post Graduate Programme in Epidemiology, Federal University of Pelotas, Pelotas, Brazil
    Lancet 377:1863-76. 2011
    ..Nevertheless, substantial challenges remain, including overmedicalisation of childbirth (nearly 50% of babies are delivered by caesarean section), maternal deaths caused by illegal abortions, and a high frequency of preterm deliveries...
  50. ncbi On the cytoadhesion of Plasmodium vivax-infected erythrocytes
    Bruna O Carvalho
    Departamento de Genetica, Evolução e Bioagentes, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, Brazil
    J Infect Dis 202:638-47. 2010
    ..vivax. The increasing number of severe manifestations of P. vivax infections, similar to those observed for severe falciparum malaria, suggests that key pathogenic mechanisms (eg, cytoadherence) might be shared by the 2 parasites...
  51. ncbi Factors influencing the composition of the intestinal microbiota in early infancy
    John Penders
    Department of Epidemiology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, PO Box 616, 6200 MD Maastricht, Netherlands
    Pediatrics 118:511-21. 2006
    ..The aim of this study was to examine the contribution of a broad range of external influences to the gut microbiotic composition in early infancy...
  52. ncbi Severe 2009 H1N1 influenza in pregnant and postpartum women in California
    Janice K Louie
    California Department of Public Health, Richmond, CA 94804, USA
    N Engl J Med 362:27-35. 2010
    ..Like previous epidemic and pandemic diseases, 2009 pandemic influenza A (H1N1) may pose an increased risk of severe illness in pregnant women...
  53. ncbi Effect of a participatory intervention with women's groups on birth outcomes in Nepal: cluster-randomised controlled trial
    Dharma S Manandhar
    Mother and Infant Research Activities MIRA, PO Box 921, Kathmandu, Nepal
    Lancet 364:970-9. 2004
    ..90% of deliveries in the poorest quintile of households happen at home. We postulated that a community-based participatory intervention could significantly reduce neonatal mortality rates...
  54. ncbi Metabolic syndrome in childhood: association with birth weight, maternal obesity, and gestational diabetes mellitus
    Charlotte M Boney
    Division of Pediatric Endocrinology and Metabolism, Department of Pediatrics, Brown Medical School and Hasbro Children s Hospital, Providence, Rhode Island, USA
    Pediatrics 115:e290-6. 2005
    ..We examined the development of MS among large-for-gestational-age (LGA) and appropriate-for-gestational age (AGA) children...
  55. pmc Rates, barriers and outcomes of HIV serostatus disclosure among women in developing countries: implications for prevention of mother-to-child transmission programmes
    Amy Medley
    Johns Hopkins University Bloomberg School of Public Health, Department of International Health, 615 N Wolfe Street, E5033, Baltimore, MD 21205, USA
    Bull World Health Organ 82:299-307. 2004
    ..This article discusses these implications and offers some strategies for safely increasing the rates of HIV status disclosure among women...
  56. pmc Maternal smoking in pregnancy and birth defects: a systematic review based on 173 687 malformed cases and 11.7 million controls
    Allan Hackshaw
    CRUK and UCL Trials Centre, University College London, 90 Tottenham Court Road, London, UK
    Hum Reprod Update 17:589-604. 2011
    ..if they reported the odds ratio (OR) for having a non-chromosomal birth defect among women who smoked during pregnancy compared with non-smokers. ORs adjusted for potential confounders were extracted (e.g...
  57. ncbi National, regional, and worldwide estimates of stillbirth rates in 2009 with trends since 1995: a systematic analysis
    Simon Cousens
    London School of Hygiene and Tropical Medicine, London, UK
    Lancet 377:1319-30. 2011
    ..We aimed to develop more reliable estimates and a time series from 1995 for 193 countries, by increasing input data, using recent data, and applying improved modelling approaches...
  58. ncbi Major risk factors for stillbirth in high-income countries: a systematic review and meta-analysis
    Vicki Flenady
    Mater Medical Research Institute, South Brisbane, QLD, Australia
    Lancet 377:1331-40. 2011
    ..Prevention strategies that target risk factors could be important in rate reduction. This systematic review and meta-analysis was done to identify priority areas for stillbirth prevention relevant to those countries...
  59. ncbi Prevention of perinatal group B streptococcal disease--revised guidelines from CDC, 2010
    Jennifer R Verani
    National Center for Immunization and Respiratory Diseases, CDC, 1600 Clifton Road, N E, MS C 23, Atlanta, GA 30333, USA
    MMWR Recomm Rep 59:1-36. 2010
    ..In the absence of a licensed GBS vaccine, universal screening and intrapartum antibiotic prophylaxis continue to be the cornerstones of early-onset GBS disease prevention...
  60. ncbi Demographic and medical consequences of the postponement of parenthood
    L Schmidt
    Section of Social Medicine, Department of Public Health, University of Copenhagen, Denmark
    Hum Reprod Update 18:29-43. 2012
    ..One main focus is on the quantitative importance of pregnancy postponement...
  61. ncbi Maternal mortality from preeclampsia/eclampsia
    Labib Ghulmiyyah
    Department of Obstetrics and Gynecology, American University of Beirut Medical Center, Beirut, Lebanon
    Semin Perinatol 36:56-9. 2012
    ..Clear protocols for early detection and management of hypertension in pregnancy at all levels of health care are required for better maternal as well as perinatal outcome...
  62. ncbi Malaria prevention in pregnancy, birthweight, and neonatal mortality: a meta-analysis of 32 national cross-sectional datasets in Africa
    Thomas P Eisele
    Department of Global Health Systems and Development, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA
    Lancet Infect Dis 12:942-9. 2012
    ..A prominent cause of low birthweight is infection with Plasmodium falciparum during pregnancy. Antimalarial intermittent preventive therapy in pregnancy (IPTp) and insecticide-treated mosquito nets (ITNs) ..
  63. ncbi Prevention of allogeneic fetal rejection by tryptophan catabolism
    D H Munn
    Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Science 281:1191-3. 1998
    ..Thus, by catabolizing tryptophan, the mammalian conceptus suppresses T cell activity and defends itself against rejection...
  64. pmc Prenatal infection and schizophrenia: a review of epidemiologic and translational studies
    Alan S Brown
    New York State Psychiatric Institute, New York, NY 10032, USA
    Am J Psychiatry 167:261-80. 2010
    ..Finally, they discuss new approaches aimed at addressing current challenges in this area of research...
  65. ncbi To err (meiotically) is human: the genesis of human aneuploidy
    T Hassold
    Department of Genetics, Case Western Reserve University, 10, 900 Euclid Avenue, Cleveland, Ohio 44106, USA
    Nat Rev Genet 2:280-91. 2001
    ..Most aneuploid conceptuses perish in utero, which makes this the leading genetic cause of pregnancy loss...
  66. ncbi International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS)
    S Miyakis
    St George Hospital, University of New South Wales, Sydney, Australia
    J Thromb Haemost 4:295-306. 2006
    ..Based on this, we propose amendments to the Sapporo criteria. We also provide definitions on features of APS that were not included in the updated criteria...
  67. ncbi Detection and characterization of placental microRNAs in maternal plasma
    Stephen S C Chim
    Centre for Research into Circulating Fetal Nucleic Acids, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    Clin Chem 54:482-90. 2008
    ..Because nucleic acids of placental origin are released into maternal plasma, we hypothesized that miRNAs produced by the placenta would also be released into maternal plasma...
  68. ncbi Effects of prenatal micronutrient and early food supplementation on maternal hemoglobin, birth weight, and infant mortality among children in Bangladesh: the MINIMat randomized trial
    Lars Ake Persson
    Department of Women s and Children s Health, International Maternal and Child Health, Uppsala University, Uppsala, Sweden
    JAMA 307:2050-9. 2012
    ..Nutritional insult in fetal life and small size at birth are common in low-income countries and are associated with serious health consequences...
  69. pmc Influence of the timing of malaria infection during pregnancy on birth weight and on maternal anemia in Benin
    Bich Tram Huynh
    Institut de Recherche pour le Developpement, Mère et Enfant Face aux Infections Tropicales, Paris, France
    Am J Trop Med Hyg 85:214-20. 2011
    Abstract. Although consequences of malaria in pregnancy are well known, the period of pregnancy in which infection has the highest impact is still unclear. In Benin, we followed up a cohort of 1,037 women through pregnancy until delivery...
  70. pmc Cognitive behaviour therapy-based intervention by community health workers for mothers with depression and their infants in rural Pakistan: a cluster-randomised controlled trial
    Atif Rahman
    School of Population, Community, and Behavioural Sciences, University of Liverpool, Liverpool, UK
    Lancet 372:902-9. 2008
    ..We integrated a cognitive behaviour therapy-based intervention into the routine work of community-based primary health workers in rural Pakistan and assessed the effect of this intervention on maternal depression and infant outcomes...
  71. ncbi Perinatal depression: a systematic review of prevalence and incidence
    Norma I Gavin
    RTI International, 3040 Cornwallis Road, PO Box 12194, Research Triangle Park, NC 27709 2194, USA
    Obstet Gynecol 106:1071-83. 2005
    ..We systematically review evidence on the prevalence and incidence of perinatal depression and compare these rates with those of depression in women at non-childbearing times...
  72. ncbi Effect of treatment of gestational diabetes mellitus on pregnancy outcomes
    Caroline A Crowther
    Department of Obstetrics and Gynaecology, University of Adelaide, Adelaide, Australia
    N Engl J Med 352:2477-86. 2005
    ..We conducted a randomized clinical trial to determine whether treatment of women with gestational diabetes mellitus reduced the risk of perinatal complications...
  73. ncbi Genome-wide fetal aneuploidy detection by maternal plasma DNA sequencing
    Diana W Bianchi
    Mother Infant Research Institute, Tufts Medical Center and Tufts University School of Medicine, Boston, Massachusetts, USA
    Obstet Gynecol 119:890-901. 2012
    ..To prospectively determine the diagnostic accuracy of massively parallel sequencing to detect whole chromosome fetal aneuploidy from maternal plasma...
  74. ncbi Epigenetic reprogramming in mouse primordial germ cells
    Petra Hajkova
    Universitat des Saarlandes, FR 8 2 Genetik, Postfach 151150, 66041 Saarbrucken, Germany
    Mech Dev 117:15-23. 2002
    ..Aberrant epigenetic reprogramming in the germ line would cause the inheritance of epimutations that may have consequences for human diseases as suggested by studies on mouse models...
  75. ncbi Circulating angiogenic factors and the risk of preeclampsia
    Richard J Levine
    Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Department of Health and Human Services, Bethesda, MD 20892, USA
    N Engl J Med 350:672-83. 2004
    ..Limited data suggest that excess circulating soluble fms-like tyrosine kinase 1 (sFlt-1), which binds placental growth factor (PlGF) and vascular endothelial growth factor (VEGF), may have a pathogenic role...
  76. pmc Antiretroviral regimens in pregnancy and breast-feeding in Botswana
    R L Shapiro
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center, 110 Francis St, Suite GB, Boston, MA 02215, USA
    N Engl J Med 362:2282-94. 2010
    The most effective highly active antiretroviral therapy (HAART) to prevent mother-to-child transmission of human immunodeficiency virus type 1 (HIV-1) in pregnancy and its efficacy during breast-feeding are unknown.
  77. pmc Induction of altered epigenetic regulation of the hepatic glucocorticoid receptor in the offspring of rats fed a protein-restricted diet during pregnancy suggests that reduced DNA methyltransferase-1 expression is involved in impaired DNA methylation and
    Karen A Lillycrop
    Development and Cell Biology, Biomedical Sciences Building, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    Br J Nutr 97:1064-73. 2007
    ..Rats were fed a control (180 g casein/kg) or a PR (90 g casein/kg) diet throughout pregnancy, and chow during lactation. Offspring were killed at postnatal day 34 (n 5 per maternal dietary group)...
  78. pmc Preventing childhood malaria in Africa by protecting adults from mosquitoes with insecticide-treated nets
    Gerry F Killeen
    Ifakara Health Research and Development Centre, Ifakara, Morogoro, United Republic of Tanzania
    PLoS Med 4:e229. 2007
    ..We therefore estimated coverage thresholds for entire populations at which individual- and community-level protection are equivalent, representing rational targets for ITN coverage beyond vulnerable groups...
  79. ncbi Intermittent preventive therapy for malaria during pregnancy using 2 vs 3 or more doses of sulfadoxine-pyrimethamine and risk of low birth weight in Africa: systematic review and meta-analysis
    Kassoum Kayentao
    Liverpool School of Tropical Medicine, Liverpool, United Kingdom
    JAMA 309:594-604. 2013
    Intermittent preventive therapy with sulfadoxine-pyrimethamine to control malaria during pregnancy is used in 37 countries in sub-Saharan Africa, and 31 of those countries use the standard 2-dose regimen...
  80. ncbi Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart
    Chen Leng Cai
    Institute of Molecular Medicine, Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Dev Cell 5:877-89. 2003
    ..Our results have implications for the development of specific cardiac lineages, left-right asymmetry, cardiac evolution, and isolation of cardiac progenitor cells...
  81. ncbi Effect of a participatory intervention with women's groups on birth outcomes and maternal depression in Jharkhand and Orissa, India: a cluster-randomised controlled trial
    Prasanta Tripathy
    Ekjut, Chakradharpur, Jharkhand, India
    Lancet 375:1182-92. 2010
    ..Community mobilisation through participatory women's groups might improve birth outcomes in poor rural communities. We therefore assessed this approach in a largely tribal and rural population in three districts in eastern India...
  82. pmc Exposure to phthalates and phenols during pregnancy and offspring size at birth
    Claire Philippat
    Institut National de la Sante et de la Recherche Medicale, Institut Albert Bonniot U823, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, Grenoble, France
    Environ Health Perspect 120:464-70. 2012
    ..Data concerning the effects of prenatal exposures to phthalates and phenols on fetal growth are limited in humans. Previous findings suggest possible effects of some phenols on male birth weight...
  83. pmc Quantifying the number of pregnancies at risk of malaria in 2007: a demographic study
    Stephanie Dellicour
    Child and Reproductive Health Group, Liverpool School of Tropical Medicine, Liverpool, UK
    PLoS Med 7:e1000221. 2010
    ..We derived global estimates of the number of women who became pregnant in 2007 in areas with Plasmodium falciparum and P. vivax transmission...
  84. ncbi Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses
    Tim F Oberlander
    Department of Pediatrics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
    Epigenetics 3:97-106. 2008
    ....
  85. ncbi Low rates of mother-to-child transmission of HIV following effective pregnancy interventions in the United Kingdom and Ireland, 2000-2006
    Claire L Townsend
    MRC Centre of Epidemiology for Child Health, UCL Institute of Child Health, University College London, London, UK
    AIDS 22:973-81. 2008
    ..The aim of this analysis was to explore the impact of different strategies to prevent mother-to-child transmission at a population level...
  86. ncbi Nutrients and foods for the primary prevention of asthma and allergy: systematic review and meta-analysis
    Ulugbek Nurmatov
    Allergy and Respiratory Research Group Centre for Population Health Sciences, University of Edinburgh, Medical School, Edinburgh, United Kingdom
    J Allergy Clin Immunol 127:724-33.e1-30. 2011
    ..Epidemiologic studies suggest that deficiencies of the nutrients selenium; zinc; vitamins A, C, D, and E; and low fruit and vegetable intake may be associated with the development of asthma and allergic disorders...
  87. pmc The Generation R Study: design and cohort update 2010
    Vincent W V Jaddoe
    The Generation R Study Group AE006, Erasmus Medical Center, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Eur J Epidemiol 25:823-41. 2010
    ..Eventually, results forthcoming from the Generation R Study have to contribute to the development of strategies for optimizing health and healthcare for pregnant women and children...
  88. ncbi The origins of the developmental origins theory
    D J P Barker
    DOHaD Division, University of Southampton, UK
    J Intern Med 261:412-7. 2007
    ..The association between low birthweight and coronary heart disease has been confirmed in longitudinal studies of men and women around the world. The developmental model of the origins of the disease offers a new way forward...
  89. pmc Environmental chemicals in pregnant women in the United States: NHANES 2003-2004
    Tracey J Woodruff
    Program on Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, Oakland, California 94612, USA
    Environ Health Perspect 119:878-85. 2011
    ....
  90. pmc HIV/AIDS stigma and refusal of HIV testing among pregnant women in rural Kenya: results from the MAMAS Study
    Janet M Turan
    Department of Obstetrics, Gynecology, and Reproductive Sciences and Center for AIDS Prevention Studies, University of California San Francisco, 50 Beale St, Suite 1200, San Francisco, CA 94105, USA
    AIDS Behav 15:1111-20. 2011
    ....
  91. pmc Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development
    Dana C Dolinoy
    Department of Radiation Oncology and University Program in Genetics and Genomics, Duke University, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 104:13056-61. 2007
    ..Thus, we present compelling evidence that early developmental exposure to BPA can change offspring phenotype by stably altering the epigenome, an effect that can be counteracted by maternal dietary supplements...
  92. pmc The influence of distance and level of care on delivery place in rural Zambia: a study of linked national data in a geographic information system
    Sabine Gabrysch
    Institute of Public Health, Ruprecht Karls Universitat, Heidelberg, Germany
    PLoS Med 8:e1000394. 2011
    ..The aim of this study was to quantify the effects of distance to care and level of care on women's use of health facilities for delivery in rural Zambia, and to compare their population impact to that of other important determinants...
  93. pmc A multicenter, randomized trial of treatment for mild gestational diabetes
    Mark B Landon
    Department of Obstetrics and Gynecology, Ohio State University, Columbus, USA
    N Engl J Med 361:1339-48. 2009
    It is uncertain whether treatment of mild gestational diabetes mellitus improves pregnancy outcomes.
  94. ncbi Regulatory T cells mediate maternal tolerance to the fetus
    Varuna R Aluvihare
    Medical Research Council, Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
    Nat Immunol 5:266-71. 2004
    b>Pregnancy constitutes a major challenge to the maternal immune system, as it has to tolerate the persistence of paternal alloantigen...
  95. ncbi Malaria in pregnancy: pathogenesis and immunity
    Stephen J Rogerson
    Department of Medicine, University of Melbourne, Parkville, Victoria, Australia
    Lancet Infect Dis 7:105-17. 2007
    Understanding of the biological basis for susceptibility to malaria in pregnancy was recently advanced by the discovery that erythrocytes infected with Plasmodium falciparum accumulate in the placenta through adhesion to molecules such ..
  96. pmc DNA sequencing of maternal plasma reliably identifies trisomy 18 and trisomy 13 as well as Down syndrome: an international collaborative study
    Glenn E Palomaki
    Division of Medical Screening and Special Testing, Department of Pathology and Laboratory Medicine, Women and Infants Hospital, Alpert Medical School of Brown University, Providence, Rhode Island, USA
    Genet Med 14:296-305. 2012
    ..To determine whether maternal plasma cell-free DNA sequencing can effectively identify trisomy 18 and 13...
  97. pmc Utilization of maternal health services among young women in Kenya: insights from the Kenya Demographic and Health Survey, 2003
    Rhoune Ochako
    African Population and Health Research Center APHRC, P, O, Box 10787, 00100 Nairobi, Kenya
    BMC Pregnancy Childbirth 11:1. 2011
    ....
  98. ncbi Induced abortion: incidence and trends worldwide from 1995 to 2008
    Gilda Sedgh
    Guttmacher Institute, New York, NY, USA
    Lancet 379:625-32. 2012
    ..Data of abortion incidence and trends are needed to monitor progress toward improvement of maternal health and access to family planning. To date, estimates of safe and unsafe abortion worldwide have only been made for 1995 and 2003...
  99. pmc Perinatal exposure to bisphenol a alters early adipogenesis in the rat
    Emmanuel Somm
    Faculty of Medicine, University of Geneva, Geneva, Switzerland
    Environ Health Perspect 117:1549-55. 2009
    ..The causes of the current obesity pandemic have not been fully elucidated. Implication of environmental endocrine disruptors such as bisphenol A (BPA) on adipose tissue development has been poorly investigated...
  100. ncbi Maternal thyroid function during early pregnancy and cognitive functioning in early childhood: the generation R study
    Jens Henrichs
    The Generation R Study, Erasmus Medical University Center, 3000 DR Rotterdam, The Netherlands
    J Clin Endocrinol Metab 95:4227-34. 2010
    Thyroid hormones are essential for neurodevelopment from early pregnancy onward. Yet population-based data on the association between maternal thyroid function in early pregnancy and children's cognitive development are sparse.
  101. ncbi Rates of caesarean section: analysis of global, regional and national estimates
    Ana P Betrán
    Department of Making Pregnancy Safer, World Health Organisation, Geneva, Switzerland
    Paediatr Perinat Epidemiol 21:98-113. 2007
    ..There is some suggestion of a direct positive association at lower levels of mortality. CS levels may respond primarily to economic determinants...

Research Grants80

  1. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  2. Anti-Inflammatory Glycosaminoglycan Ethers for Treatment of Periodontitis
    JUSTIN RODNEY SAVAGE; Fiscal Year: 2011
    ..can substantially increase the risk of systemic conditions, including cardiovascular and renal diseases, and pregnancy complications...
  3. The Primate Corpus Luteum: Functional Regression and Cardiovascular Impacts
    Randy L Bogan; Fiscal Year: 2012
    ..P4 production from the CL is required to maintain pregnancy in women through the first 6-7 weeks of gestation with the probability of pregnancy loss during this period ..
  4. Genome-wide recombination as a risk factor for nondisjunction
    NATASHA D HOLLIS; Fiscal Year: 2010
    ..Nondisjunction is the leading cause of pregnancy loss, mental retardation and birth defects...
  5. Antiphospholipid antibodies and lupus: new molecular targets for treatment
    Emilio B Gonzalez; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Antiphospholipid (aPL) antibodies (Abs) are associated with thrombosis and pregnancy loss in patients with systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS)...
  6. Polycyclic aromatic hydrocarbons and birth outcomes in Mexico City
    MARIE SYLVIA O'NEILL; Fiscal Year: 2013
    ..Although multiple factors influence birth weight and size, air pollution exposure during pregnancy has been recently explored as a contributor...
  7. MOLECULAR BASIS OF INSULIN RESISTANCE
    Maureen J Charron; Fiscal Year: 2010
    ..Consumption of a western style, high fat (HF) diet during pregnancy has also been linked to vascular dysfunction, dyslipidemia and hyperglycemia in adults...
  8. IMMUNOGENETICS OF COLLAGEN INDUCED ARTHRITIS IN MICE
    Chella David; Fiscal Year: 2009
    ..As a corollary, we will study mechanism of remission during pregnancy by studying function of T regulatory cells and antigen presenting cells...
  9. VitC to Decrease Effects of Smoking in Pregnancy on Infant Lung Function-CCC-Lead
    CYNTHIA T MCEVOY; Fiscal Year: 2013
    ..study to determine if vitamin C supplementation (500 mg daily) can decrease the effect of maternal smoking in pregnancy on offspring pulmonary function (VC-SIP)...
  10. SPEAKER TRAVEL AND SCIENTIFIC SESSION SUPPORT FOR THE TERATOLOGY SOCIETY 50TH
    Christina Chambers; Fiscal Year: 2011
    ..B12 and Neural Tube Defects: Is it Time to Fortify Food with B12?, another on Herbal Supplement Usage during Pregnancy, which will address issues surrounding use of herbal products during pregnancy and for womens health...
  11. Maternal obesity depresses essential fatty acid transport in the placenta
    PERRIE F O'TIERNEY-GINN; Fiscal Year: 2012
    ..program, utilizing appropriate animal models and human investigations to study the effect of maternal pre-pregnancy nutrition on placental growth and function, neonatal health, and the offspring's risk of future ..
  12. Protein Nitration in the Placenta
    Leslie Myatt; Fiscal Year: 2012
    ..The oxidative stress of pregnancy is increased further in preeclampsia where we identified increased placental expression of NADPH oxidase (NOX) ..
  13. Maternal obesity depresses essential fatty acid transport in the placenta
    PERRIE F O'TIERNEY-GINN; Fiscal Year: 2013
    ..program, utilizing appropriate animal models and human investigations to study the effect of maternal pre-pregnancy nutrition on placental growth and function, neonatal health, and the offspring's risk of future ..
  14. Predictors of Pregnancy Outcome in SLE and APS
    Jane E Salmon; Fiscal Year: 2012
    b>Pregnancy complications in women with the antiphospholipid syndrome (APS) and/or SLE include recurrent miscarriage, preeclampsia, placental insufficiency, and intrauterine growth restriction (IUGR)...
  15. MOLECULAR MECHANISMS OF DIOXIN ACTION
    Alvaro Puga; Fiscal Year: 2013
    ..5 gene and maternal exposure to halogenated hydrocarbons, dioxins and polychlorinated biphenyls during pregnancy are the main known risk factors for these human developmental cardiac malformations...
  16. Transgenerational effects of endocrine disruptors: epigenetics and physiology
    Rebecca A Simmons; Fiscal Year: 2013
    ..Studies in our laboratory and other investigators have shown that exposure of rodents to BPA during pregnancy results in increased adiposity and impaired glucose tolerance in adulthood...
  17. Stem Cell Homing for Treatment of Female Pelvic Floor Disorders
    Margot S Damaser; Fiscal Year: 2013
    ..Female reproductive organs and the pelvic floor are rich in elastic fibers and undergo massive remodeling during pregnancy and childbirth. Lysyl oxidase-like 1 (LOXL1) is a protein essential for elastin remodeling and homeostasis...
  18. Impacts of surface receptors [Toll like receptor (TLRs) and Fc gamma receptors (F
    Collins Ouma; Fiscal Year: 2012
    ..recent study also showed that TLR-4 and TLR-9 variants play a role in the manifestation of malaria during pregnancy. Since TLRs affect the innate and adaptive immune responses, the role of polymorphic variants within the TLR-4 ..
  19. The Role of Decidual Innate Immunity in the Pathogenesis of Preeclampsia
    Se Te Joseph Huang; Fiscal Year: 2012
    ..This study of the immunological basis of preeclampsia will result in new therapies to combat this complication during pregnancy. Hence, the welfare of affected families and society will be considerably improved.
  20. Comparative effectiveness of diabetes prevention strategies in women with GDM
    Assiamira Ferrara; Fiscal Year: 2010
    ..extend an existing KP case-management program offered by the KP Perinatal Center to patients with GDM during pregnancy. Intervention patients will be offered a postpartum lifestyle curriculum of individual telephone counseling ..
  21. Metabolic Adapation and Control of Lactation in Humans
    Morey W Haymond; Fiscal Year: 2010
    ..loss while maintaining appropriate milk production in lactating women who have gained excessive weight during pregnancy. We have provided preliminary data that rhGH increases milk production at least in part by increasing the ..
  22. The effect of trichloroethylene exposure on adverse pregnancy outcomes
    Iman Hassan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Adverse pregnancy outcomes, including preterm birth, low birth weight, small for gestational age, intrauterine growth restriction and stillbirth,are significant determinants of infant mortality and ..
  23. Novel Therapy for Preeclampsia
    James W Larrick; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Preeclampsia (PE) is a serious complication of pregnancy manifested by high blood pressure, proteinuria, and edema, sometimes with encephalopathy, seizures, and hepatic failure...
  24. Novel Zebrafish Models to Study Toxicity of PCBs and Pesticides During Pregnancy
    Lisa Satterwhite; Fiscal Year: 2009
    ....
  25. NEURAL AND ENDOCRINE CONSEQUENCES OF PARITY
    ROBERT STAFFORD BRIDGES; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Reproductive experience (i.e. pregnancy, parturition and lactation) results in long lasting alterations in the female mammal's neural and endocrine systems...
  26. Maternal nutrient restriction and nonhuman primate fetal skeletal muscle developm
    Min Du; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): SIGNIFICANCE: Fetal nutrient restriction (FNR) in human pregnancy has multiple origins and adversely affects organ development with long-term consequences for offspring health, including pre-..
  27. Complement Activation in Pregnancy and Hypertension
    Jean F Regal; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): There is a fundamental gap in understanding how placental ischemia during pregnancy leads to maternal hypertension and the only effective cure is early delivery of the placenta...
  28. The role of novel, uncultivable bacteria in incident PID
    CATHERINE L contact HAGGERTY; Fiscal Year: 2011
    ..upper genital tract, often results in long-term sequelae, including infertility, chronic pelvic pain, ectopic pregnancy, and recurrent PID...
  29. Antenatal Betamethasone in Late Preterm Gestation Lambs
    SATYANARAYANA LAKSHMINRUSIMHA; Fiscal Year: 2010
    ..However, beyond 34 wk efforts are no longer directed at prolonging pregnancy or enhancing fetal maturity...
  30. VitC to Decrease Effects of Smoking in Pregnancy on Infant Lung Function-DCC
    Cynthia D Morris; Fiscal Year: 2013
    ..study to determine if vitamin C supplementation (500 mg daily) can decrease the effect of maternal smoking in pregnancy on offspring pulmonary function (VC-SIP)...
  31. Maternal Autoantibodies: Pathogenesis of Neonatal Lupus
    JILL PAMELA BUYON; Fiscal Year: 2013
    ..The potential for relative oxygen insult during pregnancy, and the need to explain CHB- discordance in monozygotic twins, directed attention to hypoxia as an ..
  32. Integrin Regulation of Stretch-Activated Myometrial Signaling During Pregnancy an
    Heather R Burkin; Fiscal Year: 2013
    ..Dr. Buxton is a highly successful scientist with a long track record of research in uterine function during pregnancy. Dr. Buxton posesses a rare combination of medical knowledge, attention to detail, and vision...
  33. Severe H1N1 Influenza Infection During Pregnancy: Pathophysiologic Mechanisms
    Mark Phillippe; Fiscal Year: 2010
    ..S. between April and June 14th, 13% (6) occurred in pregnant women. During past influenza pandemics, pregnancy has been associated with a 2 to 3 fold higher mortality risk;however, the pathophysiologic mechanisms underlying ..
  34. Maternal One Carbon Metabolism and Low Birth Weight Infant
    Satish C Kalhan; Fiscal Year: 2013
    ..Isocaloric protein restriction in rodents during pregnancy, results in IUGR, metabolic re-programming, and long term morbidity in the off spring...
  35. Integrin Regulation of Stretch-Activated Myometrial Signaling During Pregnancy an
    Heather R Burkin; Fiscal Year: 2012
    ..Dr. Buxton is a highly successful scientist with a long track record of research in uterine function during pregnancy. Dr. Buxton possesses a rare combination of medical knowledge, attention to detail, and vision...
  36. Exploring persistent epigenetic changes after prenatal famine exposure in humans
    L H Lumey; Fiscal Year: 2010
    ..the associations between maternal famine exposure in the periconceptional period and in different stages of pregnancy on the one hand and DNA methylation patterns in adulthood on the other...
  37. Vitamin D3 Regulation of the Hypothalamic-Pituitary-Gonadal Axis
    Genevieve S Neal-Perry; Fiscal Year: 2012
    ..poor women and women of color, thus having the potential to adversely affect reproductive function and pregnancy outcomes...
  38. The Impact of Sleep-Disordered Breathing on Adverse Pregnancy Outcomes
    LOUISE M O apos BRIEN; Fiscal Year: 2010
    Hypertension during pregnancy affects 5-8% of pregnancies in the United States and contributes to serious complications for both the fetus and mother...
  39. Transgenerational effects of maternal high fat diet during pregnancy on breast ca
    Leena A Hilakivi-Clarke; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Maternal exposure to a high fat (HF) diet during pregnancy increases estrogen receptor (ER+) and ER- mammary cancer risk among female offspring in animal models and in humans...
  40. Outcomes of Infertility Treatments in Clinic and Population-Based Cohorts
    Joseph B Stanford; Fiscal Year: 2010
    ..ART produces high pregnancy rates in the short term, making it an attractive treatment...
  41. Hyperglycemia and Pregnancy Outcome(HAPO)Follow Up Study
    Boyd E Metzger; Fiscal Year: 2013
    ..The Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Follow-up Study will recruit from the cohort of women and their offspring who participated in the ..
  42. A Rapid Point-of-care Diagnostic for Neisseria gonorrhoeae STDs
    Richard F Selden; Fiscal Year: 2012
    ..Infection can also lead to sterility, ectopic pregnancy, and low birth weight...
  43. Health Care Disparities in the Pacific Islands Pacific Regional Medical Conferenc
    SAIED SAFABAKHSH; Fiscal Year: 2011
    ..Guam and the neighboring pacific islands have the highest rates of smoking, highest rates of teen pregnancy and high rate of gestational diabetes...
  44. Pluripotent human stem cells as models for normal and diseased trophoblast
    ROBERT MICHAEL ROBERTS; Fiscal Year: 2013
    ..uterine decidua and the proximate inner third of the myometrium by EVT is a characteristic feature of a healthy pregnancy, shallow invasion is associated with placental pathologies, among them pre-eclampsia (PE) and intra-uterine ..
  45. THE EFFECT OF DIOXINS ON GLUCOSE HOMEOSTASIS IN MURINE TESTES
    KENAN RIFAT OMURTAG; Fiscal Year: 2013
    ..hazards that have been implicated in aberrations in male reproductive cell function and even adverse pregnancy outcomes associated with paternal exposure. Many of these effects take several years to manifest...
  46. NATIONAL CHILDREN'S STUDY - CACHE COUNTY STUDY CENTER
    Edward Clark; Fiscal Year: 2012
    ..past experiences demonstrating profound effects of environmental exposures, such as exposures to alcohol during pregnancy and to lead in early childhood on child health and development;the special vulnerabilities of children to ..
  47. Flame Retardant and Adverse Perinatal Outcome (FRAPO)
    Morgan R Peltier; Fiscal Year: 2013
    ..also been isolated from the placenta, umbilical chord, amniotic fluid and fetal membranes but their effects on pregnancy outcome are unclear...
  48. Graves'Disease Therapy Risks to Mother and Fetus
    Scott A Rivkees; Fiscal Year: 2013
    ..of childbearing age with GD in the United States (US), and that 4,000 to 8,000 women are treated for GD during pregnancy annually. Antithyroid drug (ATD) therapy is the recommended treatment of GD during pregnancy...
  49. Human developmental toxicity of metal mixture exposure from e-waste recycling
    Aimin Chen; Fiscal Year: 2010
    ..Aims: 1) Characterize the e-waste metal mixture exposure in pregnant women and their fetuses;2) Examine adverse pregnancy outcomes associated with e-waste metal mixture exposure;and 3) Investigate neurodevelopmental toxicity and ..
  50. Climate Change and Adverse Birth Outcomes: Assessing the Vulnerability of Pregnan
    Shao Lin; Fiscal Year: 2013
    ..these gaps by examining whether exposures to various extreme weather conditions or their joint effects during pregnancy are associated with adverse birth outcomes, including selected birth defects, preterm birth, and fetal growth ..
  51. Protein Modifications and Unfolded Protein Response in Diabetic Embryopathy
    Zhiyong Zhao; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Diabetes mellitus in early pregnancy causes birth defects, even when perinatal care is available...
  52. Maternal Obesity and Gestational Diabetes: Impact on Metabolome
    William L Lowe; Fiscal Year: 2013
    ..applicant): Offspring of mothers with obesity and/or pre-existing or gestational diabetes mellitus (GDM) during pregnancy are at increased risk for obesity and altered glucose metabolism as children and adults, leading to a proposed "..
  53. Understanding thyroid hormone regulation of neurogenesis in the cochlea
    Mirna Mustapha; Fiscal Year: 2013
    ..congenital secondary hypothyroidism causes profound deafness in Pit1dw mice and thyroid supplementation during pregnancy and early neonatal life is sufficient to protect against hearing impairment...
  54. Cooperative Multicenter Reproductive Medicine Network (U10)
    MARCELLE IVONNE CEDARS; Fiscal Year: 2013
    ..would offer women the first treatment to overcome the impact of aging on the oocyte and the resultant lowered pregnancy potential...
  55. A Rapid Point-of-care Diagnostic for C.trachomitis STDs
    RICHARD F contact SELDEN; Fiscal Year: 2010
    ..which leads to increased transmission and the sequelae of pelvic inflammatory disease, infertility and ectopic pregnancy. Current diagnostics require extensive technical expertise, are expensive and take days for results, leading to ..
  56. Role of Physico-chemical Properties in the Reprotoxicity of Inhaled Cd NP.
    JUDITH TERRY ZELIKOFF; Fiscal Year: 2010
    ..are a result of property-dependent effects on the release and actions of select hormones/cytokines important for pregnancy maintenance and parturition. Timed-pregnant mice exposed to relevant levels of either nanosize (i.e...
  57. Validation of Novel Infertility Biomarker
    PETER SUTOVSKY SUTOVSKY; Fiscal Year: 2012
    ..data demonstrate that the increased semen content of SPTRX3-carrying spermatozoa coincides with reduced pregnancy rates after ART...
  58. The New England Family Study: Fifty Year Post-Perinatal Follow-Up for Life Course
    ERIC contact LOUCKS; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Little is known regarding how conditions during pregnancy and early life may impact epigenetic alterations and aging processes that could subsequently manifest in midlife as atherosclerosis, type 2 ..
  59. Iodine Nutrition and Thyroid Disease During Pregnancy and Lactation
    ANGELA MEI TIN LEUNG; Fiscal Year: 2013
    ..aimed at specific strategies of achieving adequate iodine nutrition and normal thyroid function during pregnancy and lactation...
  60. Role of SIRT3 in fetal programming and kidney dysfunction
    Karen R Jonscher; Fiscal Year: 2013
    ..in regulating mitochondrial response to maternal over-nutrition, and 4) administer a potent anti-oxidant during pregnancy and lactation to rescue developmentally programmed "lipotoxicity...
  61. Genetics of Spontaneous Pelvic Organ Prolapse in the Mouse
    Jay E Reeder; Fiscal Year: 2010
    ..inherited as an autosomal dominant trait, is seen in both males and females and no precipitating event (such as pregnancy or parturition) is necessary...
  62. Trophoblast MHC-I: Trigger for Immune-Mediated Rejection of Cloned Bovine Fetuses
    Kenneth L White; Fiscal Year: 2011
    ..Immune-mediated abortion is an important, although poorly understood and often unrecognized, cause of pregnancy failure in women...
  63. Apoptosis and Trophoblast Fusion
    NEAL STEWART ROTE; Fiscal Year: 2010
    Common pregnancy complications, such as intrauterine growth restriction (IUGR) and miscarriage, are strongly associated with abnormal development of the placenta...
  64. Predictors of Dietary Quality in Low-Income Pregnant Women
    Eileen R Fowles; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Poor maternal dietary quality in the 1st trimester of pregnancy can alter the intrauterine nutritional environment and adversely affect placental development and subsequent fetal development and ..
  65. Traffic-Related Air Pollution and Ultrasound Measures of Fetal Growth
    MICHELLE WILHELM TURNER; Fiscal Year: 2010
    ..reporting increased risks of adverse birth outcomes for women highly exposed to outdoor air pollution during pregnancy, the most important questions remain unanswered;specifically, what are the relevant sources and types of ..
  66. DHA, Inflammation, and Insulin Sensitivity in Obese Pregnant Women
    Debra Krummel; Fiscal Year: 2009
    ..Obesity in pregnancy is rapidly becoming a major obstetric complication since it increases the risk of gestational diabetes and pre-..
  67. Assessment of Nicotine Metabolism Among Underserved Pregnant Women from NE SCRIPT
    Donna Parker; Fiscal Year: 2007
    ..Project Summary/Abstract: Smoking during pregnancy is of particular concern because smoking affects not only the health of the woman but also the health of her ..
  68. Genomic actions of progesterone receptors in human myometrial cells
    Sam Mesiano; Fiscal Year: 2010
    ..Our central hypothesis is that in human pregnancy progesterone promotes myometrial quiescence via nPR-mediated genomic pathways and that parturition involves ..
  69. Vascular Angiotensin Type-2 Receptor in Normal and Hypertensive Pregnancy
    Raouf A Khalil; Fiscal Year: 2010
    ..system and increased vasoconstrictive response to angiotensin II (AngII) are observed during hypertension in pregnancy (HTN-Preg) and preeclampsia...
  70. A Collaborative, Intersectional Approach to Health Disparities in Pregnancy
    Tina Bloom; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Serious health disparities in pregnancy outcomes (maternal and infant mortality, preterm birth, and low birth weight) exist, and in many cases, are growing worse...
  71. PREGNANCY & HORMONE EFFECTS ON KIDNEY & URINARY TRACT
    Linda Shortliffe; Fiscal Year: 1999
    In this proposal renal and urinary tract changes associated with pregnancy, the post-partum period, and alterations in estrogen and progesterone levels will be defined...
  72. Development of a mouse model of obesity in pregnancy
    Thomas Jansson; Fiscal Year: 2009
    ..The objective of this R03 application is to develop and establish feasibility of a mouse model of obesity in pregnancy in order to determine the mechanisms underlying fetal overgrowth in response to high fat diet and increased ..
  73. NATIONAL CHILDREN'S STUDY COORDINATING CENTER
    Elaine D Eaker; Fiscal Year: 2009
    ..past experiences demonstrating profound effects of environmental exposures, such as exposures to alcohol during pregnancy and to lead in early childhood on child health and development;the special vulnerabilities of children to ..
  74. Neuroactive Steroids and Seizure Control during Pregnancy in Women with Epilepsy
    PAGE BUCKHANNAN PENNELL; Fiscal Year: 2010
    ..3 million women of child-bearing age in the United States. Seizures during pregnancy can cause increased risks to both the mother and fetus...
  75. Wed Based Outreach for Pregnant African American Women
    JoAnne Herman; Fiscal Year: 2001
    ..Low-income women are at an even higher risk for poor pregnancy outcomes...
  76. ROLE OF SEROTONIN IN PREGNANCY-RELATED HYPERTENSION
    Carl Weiner; Fiscal Year: 1992
    This proposal seeks to expand our understanding of arterial smooth muscle control during pregnancy and investigate a working hypothesis of the mechanism for preeclamptic hypertension...
  77. REGULATION OF ENDOMETRIAL PROSTAGLANDIN F-2A SECRETION
    MARK MIRANDO; Fiscal Year: 1999
    ..Understanding the factors associated with conceptus survival during the period of early pregnancy will lead to development of techniques which improve these critical reproductive processes resulting ina greater ..
  78. Endocrine Status of MG Stroma Alters Breast CA Invasion
    Pepper Schedin; Fiscal Year: 2004
    The relationship between reproductive history and breast cancer is complex. A full term pregnancy in younger women is protective against breast cancer later in life, while a first full term pregnancy after 40 years of age is associated ..
  79. MOTOR-Maternal Oral Therapy to Reduce Obstetric Risk
    STEVEN NMN OFFENBACHER; Fiscal Year: 2010
    Recent studies have confirmed that there is an association between maternal periodontal disease and pregnancy complications that result in premature delivery [e.g. gestational age (GA)<37 weeks: adjusted odds ratio 2.1(CI95%:1.12, 4...