physiological adaptation

Summary

Top Publications

  1. pmc Soft sweeps: molecular population genetics of adaptation from standing genetic variation
    Joachim Hermisson
    Section of Evolutionary Biology, Department of Biology II, Ludwig Maximilians University Munich, Germany
    Genetics 169:2335-52. 2005
  2. ncbi Molecular responses to dehydration and low temperature: differences and cross-talk between two stress signaling pathways
    K Shinozaki
    Laboratory of Plant Molecular Biology, Tsukuba Life Science Center, Institute of Physical and Chemical Research RIKEN, Tsukuba, 305 0074, Japan
    Curr Opin Plant Biol 3:217-23. 2000
  3. ncbi OsDREB genes in rice, Oryza sativa L., encode transcription activators that function in drought-, high-salt- and cold-responsive gene expression
    Joseph G Dubouzet
    Biological Resources Division, Japan International Research Center for Agricultural Sciences JIRCAS, 1 1 Ohwashi, Tsukuba, Ibaraki 305 8686, Japan
    Plant J 33:751-63. 2003
  4. ncbi Optimality and evolutionary tuning of the expression level of a protein
    Erez Dekel
    Department of Molecular Cell Biology and Department of Physics of Complex Systems, The Weizmann Institute of Science, Rehovot 76100, Israel
    Nature 436:588-92. 2005
  5. ncbi Different trajectories of parallel evolution during viral adaptation
    H A Wichman
    Department of Biological Sciences, University of Idaho, Moscow, ID 83844, USA
    Science 285:422-4. 1999
  6. ncbi An implicit plan overrides an explicit strategy during visuomotor adaptation
    Pietro Mazzoni
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Neurosci 26:3642-5. 2006
  7. ncbi Experimental evolution of parasites
    D Ebert
    Universitat Basel, Zoologisches Institut, Rheinsprung 9, 4051 Basel, Switzerland
    Science 282:1432-5. 1998
  8. pmc Interacting adaptive processes with different timescales underlie short-term motor learning
    Maurice A Smith
    Division of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA
    PLoS Biol 4:e179. 2006
  9. pmc Transcriptome changes for Arabidopsis in response to salt, osmotic, and cold stress
    Joel A Kreps
    Torrey Mesa Research Institute, Syngenta, 3115 Merryfield Row, San Diego, California 92121, USA
    Plant Physiol 130:2129-41. 2002
  10. ncbi Selection on heritable phenotypic plasticity in a wild bird population
    Daniel H Nussey
    Netherlands Institute of Ecology NIOO KNAW, Post Office Box 40, 6666 ZG Heteren, Netherlands
    Science 310:304-6. 2005

Detail Information

Publications317 found, 100 shown here

  1. pmc Soft sweeps: molecular population genetics of adaptation from standing genetic variation
    Joachim Hermisson
    Section of Evolutionary Biology, Department of Biology II, Ludwig Maximilians University Munich, Germany
    Genetics 169:2335-52. 2005
    ..We find that soft sweeps with weaker selective footprints are likely under both scenarios if the mutation rate and/or the selection coefficient is high...
  2. ncbi Molecular responses to dehydration and low temperature: differences and cross-talk between two stress signaling pathways
    K Shinozaki
    Laboratory of Plant Molecular Biology, Tsukuba Life Science Center, Institute of Physical and Chemical Research RIKEN, Tsukuba, 305 0074, Japan
    Curr Opin Plant Biol 3:217-23. 2000
    ..Recent studies are providing evidence of differences between dehydration-signaling and cold-stress-signaling cascades, and of cross-talk between them...
  3. ncbi OsDREB genes in rice, Oryza sativa L., encode transcription activators that function in drought-, high-salt- and cold-responsive gene expression
    Joseph G Dubouzet
    Biological Resources Division, Japan International Research Center for Agricultural Sciences JIRCAS, 1 1 Ohwashi, Tsukuba, Ibaraki 305 8686, Japan
    Plant J 33:751-63. 2003
    ..OsDREB1A is potentially useful for producing transgenic monocots that are tolerant to drought, high-salt, and/or cold stresses...
  4. ncbi Optimality and evolutionary tuning of the expression level of a protein
    Erez Dekel
    Department of Molecular Cell Biology and Department of Physics of Complex Systems, The Weizmann Institute of Science, Rehovot 76100, Israel
    Nature 436:588-92. 2005
    ..Thus, protein expression from the lac operon seems to be a solution of a cost-benefit optimization problem, and can be rapidly tuned by evolution to function optimally in new environments...
  5. ncbi Different trajectories of parallel evolution during viral adaptation
    H A Wichman
    Department of Biological Sciences, University of Idaho, Moscow, ID 83844, USA
    Science 285:422-4. 1999
    ..However, the order of these changes differed between replicates, and parallel substitutions did not reflect the changes with the largest beneficial effects or indicate a common trajectory of adaptation...
  6. ncbi An implicit plan overrides an explicit strategy during visuomotor adaptation
    Pietro Mazzoni
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Neurosci 26:3642-5. 2006
    ..This suggests that the motor system requires that planned and executed trajectories remain congruous in visual space, and enforces this correspondence even at the expense of an opposing explicit task goal...
  7. ncbi Experimental evolution of parasites
    D Ebert
    Universitat Basel, Zoologisches Institut, Rheinsprung 9, 4051 Basel, Switzerland
    Science 282:1432-5. 1998
    ..Understanding why parasite virulence seldom escalates similarly in natural populations could help us to manage virulence and deal with emerging diseases...
  8. pmc Interacting adaptive processes with different timescales underlie short-term motor learning
    Maurice A Smith
    Division of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA
    PLoS Biol 4:e179. 2006
    ..Our results suggest that motor adaptation depends on at least two distinct neural systems that have different sensitivity to error and retain information at different rates...
  9. pmc Transcriptome changes for Arabidopsis in response to salt, osmotic, and cold stress
    Joel A Kreps
    Torrey Mesa Research Institute, Syngenta, 3115 Merryfield Row, San Diego, California 92121, USA
    Plant Physiol 130:2129-41. 2002
    ..Although these results identify hundreds of potentially important transcriptome changes, the biochemical functions of many stress-regulated genes remain unknown...
  10. ncbi Selection on heritable phenotypic plasticity in a wild bird population
    Daniel H Nussey
    Netherlands Institute of Ecology NIOO KNAW, Post Office Box 40, 6666 ZG Heteren, Netherlands
    Science 310:304-6. 2005
    ..This temporal trend is concurrent with climate change causing a mismatch between the breeding times of the birds and their caterpillar prey. Continued selection on plasticity can act to alleviate this mismatch...
  11. ncbi Quantifying generalization from trial-by-trial behavior of adaptive systems that learn with basis functions: theory and experiments in human motor control
    Opher Donchin
    Laboratory for Computational Motor Control, Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, Maryland 21205 2195, USA
    J Neurosci 23:9032-45. 2003
    ....
  12. ncbi Visual adaptation: physiology, mechanisms, and functional benefits
    Adam Kohn
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Neurophysiol 97:3155-64. 2007
    ..I conclude with a brief discussion of some important open questions in the field...
  13. ncbi Applications of prism adaptation: a tutorial in theory and method
    Gordon M Redding
    Department of Psychology, Illinois State University, Campus Box 4620, Normal, IL 61790 4620, USA
    Neurosci Biobehav Rev 29:431-44. 2005
    ....
  14. ncbi Adaptive norm-based coding of facial identity
    Gillian Rhodes
    School of Psychology, The University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia
    Vision Res 46:2977-87. 2006
    ..Component identities were also harder to detect in morphs of opposite than non-opposite face pairs. We propose an adaptive norm-based coding model of face identity...
  15. pmc Mechanisms causing rapid and parallel losses of ribose catabolism in evolving populations of Escherichia coli B
    V S Cooper
    Center for Microbial Ecology, Michigan State University, East Lansing, Michigan 48824, USA
    J Bacteriol 183:2834-41. 2001
    ....
  16. ncbi Adaptive radiation in a heterogeneous environment
    P B Rainey
    Department of Plant Sciences, University of Oxford, UK
    Nature 394:69-72. 1998
    ..These results demonstrate that the elementary processes of mutation and selection alone are sufficient to promote rapid proliferation of new designs and support the theory that trade-offs in competitive ability drive adaptive radiation...
  17. ncbi Genome divergence in two Prochlorococcus ecotypes reflects oceanic niche differentiation
    Gabrielle Rocap
    School of Oceanography, University of Washington, Seattle, Washington 98195, USA
    Nature 424:1042-7. 2003
    ..Some of these genes have obvious roles in determining the relative fitness of the ecotypes in response to key environmental variables, and hence in regulating their distribution and abundance in the oceans...
  18. ncbi Constraint to adaptive evolution in response to global warming
    J R Etterson
    University of Minnesota, Department of Ecology, Evolution and Behavior, Minnesota Center for Community Genetics, 1987 Upper Buford Circle, St Paul, MN 55108, USA
    Science 294:151-4. 2001
    ..Predicted rates of evolutionary response are much slower than the predicted rate of climate change...
  19. pmc Impacts of climate warming on terrestrial ectotherms across latitude
    Curtis A Deutsch
    Program on Climate Change and Department of Oceanography and Department of Biology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 105:6668-72. 2008
    ..Our analyses imply that, in the absence of ameliorating factors such as migration and adaptation, the greatest extinction risks from global warming may be in the tropics, where biological diversity is also greatest...
  20. ncbi Incipient speciation by divergent adaptation and antagonistic epistasis in yeast
    Jeremy R Dettman
    Department of Ecology and Evolutionary Biology, University of Toronto, Mississauga, Ontario, L5L 1C6, Canada
    Nature 447:585-8. 2007
    ....
  21. doi Population genomics of marine fishes: identifying adaptive variation in space and time
    Einar E Nielsen
    Technical University of Denmark, National Institute of Aquatic Resources, Vejlsøvej 39, Silkeborg, Denmark
    Mol Ecol 18:3128-50. 2009
    ....
  22. doi Parallel adaptations to high temperatures in the Archaean eon
    Bastien Boussau
    Laboratoire de Biometrie et Biologie Evolutive, CNRS, Universite de Lyon, Université Lyon I, 43 Boulevard du 11 Novembre, 69622 Villeurbanne, France
    Nature 456:942-5. 2008
    ..This analysis unifies apparently contradictory results into a coherent depiction of the evolution of an ecological trait over the entire tree of life...
  23. ncbi Components of sensorimotor adaptation in young and elderly subjects
    Otmar Bock
    Institute for Physiology and Anatomy, German Sport University, 50927, Koln, Germany
    Exp Brain Res 160:259-63. 2005
    ..This conclusion is supported by two additional findings: compared with young subjects our seniors performed less well on a cognitive screening test and acquired no explicit knowledge about the nature of the imposed visual distortion...
  24. ncbi The art of the probable: system control in the adaptive immune system
    R N Germain
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1892, USA
    Science 293:240-5. 2001
    ....
  25. ncbi Evidence of HIV-1 adaptation to HLA-restricted immune responses at a population level
    Corey B Moore
    Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Level 2 North Block, Royal Perth Hospital, Wellington Street, WA 6000, Australia
    Science 296:1439-43. 2002
    ..At a population level, the degree of HLA-associated selection in viral sequence was predictive of viral load. These results support a fundamental role for HLA-restricted immune responses in driving and shaping HIV-1 evolution in vivo...
  26. pmc Time course of change in vasodilator function and capacity in response to exercise training in humans
    Toni M Tinken
    Research Institute for Sport and Exercise Science, Liverpool John Moores University, Liverpool, UK
    J Physiol 586:5003-12. 2008
    ....
  27. pmc Importance of hemodynamic forces as signals for exercise-induced changes in endothelial cell phenotype
    M Harold Laughlin
    Department of Biomedical Sciences, College of Veterinary Medicine, 1600 E Rollins Rd, University of Missouri, Columbia, MO 65211, USA
    J Appl Physiol (1985) 104:588-600. 2008
    ..We conclude that available evidence suggests that exercise signals formation of beneficial endothelial cell phenotype at least in part through changes in SS and wall stretch in the arteries...
  28. ncbi Escherichia coli acid resistance: tales of an amateur acidophile
    John W Foster
    Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile, Alabama 36695, USA
    Nat Rev Microbiol 2:898-907. 2004
    ..Surprisingly, certain microorganisms that grow at neutral pH have elegantly regulated systems that enable survival during excursions into acidic environments. The best-characterized acid-resistance system is found in E. coli...
  29. ncbi Adaptation to gradual as compared with sudden visuo-motor distortions
    F A Kagerer
    Motor Control Laboratory, Arizona State University, Tempe 85287 0404, USA
    Exp Brain Res 115:557-61. 1997
    ..Results suggest that gradually increasing feedback distortion allows more complete adaptation than a large, sudden distortion onset...
  30. ncbi Maternal effects provide phenotypic adaptation to local environmental conditions
    Laura F Galloway
    Department of Biology, University of Virginia, Charlottesville, VA 22904 4328, USA
    New Phytol 166:93-9. 2005
    ..Evaluating maternal environmental effects in an ecological context demonstrates that they may provide phenotypic adaptation to local environmental conditions...
  31. ncbi Concurrent adaptations of left and right arms to opposite visual distortions
    Otmar Bock
    Institute of Physiology and Anatomy, German Sport University, 50927 Koln, Germany
    Exp Brain Res 162:513-9. 2005
    ..The reduced aftereffects observed under bimanual conditions can be attributed to the well-known phenomenon of bimanual coupling, which is unrelated to adaptation...
  32. ncbi Adaptive evolution of non-coding DNA in Drosophila
    Peter Andolfatto
    Section of Ecology, Behavior and Evolution, Division of Biological Sciences, University of California San Diego, La Jolla, California 92093, USA
    Nature 437:1149-52. 2005
    ..These results imply that, although positive selection is clearly an important facet of protein evolution, adaptive changes to non-coding DNA might have been considerably more common in the evolution of D. melanogaster...
  33. ncbi Kin selection and parasite evolution: higher and lower virulence with hard and soft selection
    L Chao
    Department of Biology, University of California San Diego 92093, USA
    Q Rev Biol 75:261-75. 2000
    ..We recognize that hard selection for virulence is more difficult to document, but we take our results to suggest that a kin selection model with soft selection may have general applicability...
  34. pmc Arabidopsis AtMYC2 (bHLH) and AtMYB2 (MYB) function as transcriptional activators in abscisic acid signaling
    Hiroshi Abe
    Biological Resources Division, Japan International Research Center for Agricultural Sciences, 1 1 Ohwashi, Tsukuba, Ibaraki 305 8686, Japan
    Plant Cell 15:63-78. 2003
    ..These results indicate that both AtMYC2 and AtMYB2 proteins function as transcriptional activators in ABA-inducible gene expression under drought stress in plants...
  35. pmc Cerebellar contributions to adaptive control of saccades in humans
    Minnan Xu-Wilson
    Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 29:12930-9. 2009
    ....
  36. ncbi Introduced species and their missing parasites
    Mark E Torchin
    Marine Science Institute and Department of Ecology, Evolution and Marine Biology, University of California, Santa Barbara, California 93106, USA
    Nature 421:628-30. 2003
    ....
  37. ncbi The genetics of adaptive shape shift in stickleback: pleiotropy and effect size
    Arianne Y K Albert
    Department of Zoology and Biodiversity Research Centre, University of British Columbia, Vancouver, BC, Canada
    Evolution 62:76-85. 2008
    ..Our results are consistent with predictions of the geometric model of adaptation. Shape evolution in stickleback results from a few genes with large and possibly widespread effects and multiple genes of smaller effect...
  38. ncbi Cellular and developmental adaptations to hypoxia: a Drosophila perspective
    Nuria Magdalena Romero
    Instituto Leloir, Patricias Argentinas, Buenos Aires, Argentina
    Methods Enzymol 435:123-44. 2007
    ..Paradoxically, Sima is a negative regulator of growth. This suggests that Sima is engaged in a negative feedback loop that limits growth upon stimulation of InR/TOR pathways...
  39. pmc Role of guanylate cyclase-activating proteins (GCAPs) in setting the flash sensitivity of rod photoreceptors
    A Mendez
    The Mary D Allen Laboratory for Vision Research, Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles 90089 9112, USA
    Proc Natl Acad Sci U S A 98:9948-53. 2001
    ..We conclude that GCAPs strongly regulate GC activity in mouse rods, decreasing the flash sensitivity in darkness and increasing the incremental flash sensitivity in bright steady light, thereby extending the rod's operating range...
  40. pmc Improving water use in crop production
    J I L Morison
    Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, UK
    Philos Trans R Soc Lond B Biol Sci 363:639-58. 2008
    ....
  41. pmc Enhanced accumulation of BiP in transgenic plants confers tolerance to water stress
    F C Alvim
    Departamento de Biologia Vegetal, , , Minas Gerais, Brazil
    Plant Physiol 126:1042-54. 2001
    ..These results suggest that overexpression of BiP in plants may prevent endogenous oxidative stress...
  42. pmc Evolutionary and functional insights into the mechanism underlying high-altitude adaptation of deer mouse hemoglobin
    Jay F Storz
    School of Biological Sciences, University of Nebraska, Lincoln, NE 68588, USA
    Proc Natl Acad Sci U S A 106:14450-5. 2009
    ..The experimental measures of O(2)-binding properties corroborated the tests of selection by demonstrating a functional difference between the products of alternative alleles...
  43. ncbi Limited transfer of learning between unimanual and bimanual skills within the same limb
    Daichi Nozaki
    Centre for Neuroscience Studies, Department of Anatomy and Cell Biology, Queen s University, Kingston, Ontario K7L 3N6, Canada
    Nat Neurosci 9:1364-6. 2006
    ..These results suggest partial, but not complete, overlap in the learning processes involved in the acquisition of unimanual and bimanual skills...
  44. ncbi Transgenerational plasticity is adaptive in the wild
    Laura F Galloway
    Department of Biology, University of Virginia, Charlottesville, VA 22904 4328, USA
    Science 318:1134-6. 2007
    ..4 times greater fitness than otherwise. Transgenerational plasticity has evolved in response to natural variation in light and provides a flexible mechanism by which sedentary organisms cope with heterogeneous environments...
  45. ncbi Remodeling of blood vessels: responses of diameter and wall thickness to hemodynamic and metabolic stimuli
    Axel R Pries
    Department of Physiology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Hypertension 46:725-31. 2005
    ....
  46. ncbi Significance of the V-type ATPase for the adaptation to stressful growth conditions and its regulation on the molecular and biochemical level
    K J Dietz
    Department of Physiology and Biochemistry of Plants, Faculty of Biology, University of Bielefeld, D 33501 Bielefeld, Germany
    J Exp Bot 52:1969-80. 2001
    ..The mechanisms known to regulate the V-ATPase are summarized in this paper with an emphasis on their implications for growth and development under stress...
  47. ncbi Response of plant metabolism to too little oxygen
    Peter Geigenberger
    Max Planck Institute of Molecular Plant Physiology, Am Muhlenberg 1, 14476 Golm, Germany
    Curr Opin Plant Biol 6:247-56. 2003
    ..Recently, advances have been made in elucidating possible oxygen-sensing systems and regulatory components that are involved in these responses...
  48. ncbi Adaptation and the cost of complexity
    H A Orr
    Department of Biology, University of Rochester, New York 14627, USA
    Evolution 54:13-20. 2000
    ..The present results also suggest that one can define an effective number of dimensions characterizing an adapting species...
  49. ncbi Duration-dependent FMRI adaptation and distributed viewer-centered face representation in human visual cortex
    Fang Fang
    Department of Psychology, University of Minnesota, 75 East River Parkway, Minneapolis, MN 55455, USA
    Cereb Cortex 17:1402-11. 2007
    ..Our findings suggest that long- and short-term fMRI adaptations may reflect selective properties of different neuronal mechanisms...
  50. ncbi Bacterial biofilms: from the natural environment to infectious diseases
    Luanne Hall-Stoodley
    Department of Veterinary Molecular Microbiology, Departments of Microbiology and Civil Engineering, Center for Biofilm Engineering, Montana State University, Bozeman, Montana, USA
    Nat Rev Microbiol 2:95-108. 2004
    ..The implications of these survival and propagative mechanisms in the context of both the natural environment and infectious diseases are discussed in this review...
  51. ncbi Prototype-referenced shape encoding revealed by high-level aftereffects
    D A Leopold
    , , Germany
    Nat Neurosci 4:89-94. 2001
    ..The results suggest that the encoding of faces and other complex patterns draws upon contrastive neural mechanisms that reference the central tendency of the stimulus category...
  52. pmc Goalpha regulates olfactory adaptation by antagonizing Gqalpha-DAG signaling in Caenorhabditis elegans
    Masahiro Matsuki
    Molecular Genetics Research Laboratory and Graduate Program in Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 103:1112-7. 2006
    ..Our results suggest that down-regulation of EGL-30-DAG signaling by GOA-1 underlies olfactory adaptation and plasticity of chemotaxis...
  53. ncbi Representation of perceived object shape by the human lateral occipital complex
    Z Kourtzi
    Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 293:1506-9. 2001
    ..These data indicate that the LOC represents not simple image features, but rather higher level shape information...
  54. ncbi Transcriptional and physiological adaptation to defective protein-O-mannosylation in Candida albicans
    Pilar D Cantero
    Institut fur Mikrobiologie, Heinrich Heine Universitat Dusseldorf, Dusseldorf, Germany
    Mol Microbiol 64:1115-28. 2007
    ..While known signalling pathways modulate adaptation for a short-term, long-term adaptation requires calcineurin, adjustments of remaining Pmt activities and of glycolytic flow...
  55. ncbi Evolution of high mutation rates in experimental populations of E. coli
    P D Sniegowski
    Department of Biology, University of Pennsylvania, Philadelphia 19104, USA
    Nature 387:703-5. 1997
    ..Our results corroborate computer simulations of mutator evolution in adapting clonal populations, and may help to explain observations that associate high mutation rates with emerging pathogens and with certain cancers...
  56. pmc The small noncoding DsrA RNA is an acid resistance regulator in Escherichia coli
    Richard A Lease
    Wadsworth Center, New York State Department of Health, Center for Medical Sciences, Albany, New York, USA
    J Bacteriol 186:6179-85. 2004
    ..Whether DsrA targets acid resistance genes directly by base pairing or indirectly via perturbation of RpoS and/or H-NS is not known, but in either event, our results suggest that DsrA RNA may enhance the virulence of pathogenic E. coli...
  57. pmc E-CAI: a novel server to estimate an expected value of Codon Adaptation Index (eCAI)
    Pere Puigbò
    Evolutionary Genomics Group, Department of Biochemistry and Biotechnology, Rovira i Virgili University URV, Campus Sescelades, c Marcelli Domingo s n, 43007 Tarragona, Spain
    BMC Bioinformatics 9:65. 2008
    ..Though several freely available programs calculate the CAI for a given DNA sequence, none of them corrects for compositional biases or provides confidence intervals for CAI values...
  58. ncbi Long-term experimental evolution in Escherichia coli. XIII. Phylogenetic history of a balanced polymorphism
    Daniel E Rozen
    Ecology, Evolutionary Biology, and Behavior Program, Michigan State University, East Lansing, MI 48824, USA
    J Mol Evol 61:171-80. 2005
    ..Based on their phylogenetic history and independent evolutionary trajectories, S and L fulfill Cohan's criteria for being different asexual species...
  59. ncbi Evolution of thermal dependence of growth rate of Escherichia coli populations during 20,000 generations in a constant environment
    V S Cooper
    Center for Microbial Ecology, Michigan State University, East Lansing 48824, USA
    Evolution 55:889-96. 2001
    ..Antagonistic pleiotropy therefore is more likely to be responsible for the evolution of thermal specialization observed in maximum growth rate...
  60. ncbi Endothelial function of young healthy males following whole body resistance training
    M Rakobowchuk
    Dept of Kinesiology, Ivor Wynne Centre, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4K1
    J Appl Physiol 98:2185-90. 2005
    ..Thus arterial adaptations with high-pressure loads, such as those experienced during resistance exercise, may be quite different compared with endurance training...
  61. pmc High guanine-cytosine content is not an adaptation to high temperature: a comparative analysis amongst prokaryotes
    L D Hurst
    Department of Biology and Biochemistry, University of Bath, UK
    Proc Biol Sci 268:493-7. 2001
    ..Against the expectations of the thermal adaptation hypothesis, within prokaryotes GC content in protein-coding genies, even at relatively freely evolving sites, cannot be considered an adaptation to the thermal environment...
  62. pmc Costs and benefits of cold acclimation in field-released Drosophila
    Torsten N Kristensen
    Department of Genetics and Biotechnology, University of Aarhus, P O Box 50, DK 8830 Tjele, Denmark
    Proc Natl Acad Sci U S A 105:216-21. 2008
    ....
  63. pmc Understanding the adaptive growth strategy of Lactobacillus plantarum by in silico optimisation
    Bas Teusink
    Top Institute Food and Nutrition WCFS, Wageningen, The Netherlands
    PLoS Comput Biol 5:e1000410. 2009
    ..Hence, these results provide thorough understanding of adaptive evolution, allowing in silico predictions of the resulting flux states, provided that the selective growth conditions favor yield optimization as the winning strategy...
  64. pmc Regulatory and metabolic rewiring during laboratory evolution of ethanol tolerance in E. coli
    Hani Goodarzi
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Mol Syst Biol 6:378. 2010
    ..Remarkably, these laboratory-evolved strains, by and large, follow the same adaptive paths as inferred from our coarse-grained search of the fitness landscape...
  65. ncbi Evolution of a polyphenism by genetic accommodation
    Yuichiro Suzuki
    Department of Biology, Duke University, Durham, NC 27708, USA
    Science 311:650-2. 2006
    ..Evidently, mechanisms that regulate developmental hormones can mask genetic variation and act as evolutionary capacitors, facilitating the origin of novel adaptive phenotypes...
  66. pmc Long-term experimental evolution in Escherichia coli. XI. Rejection of non-transitive interactions as cause of declining rate of adaptation
    J Arjan G M de Visser
    Laboratory of Genetics, Wageningen University, Arboretumlaan 4, 6703 BD Wageningen, The Netherlands
    BMC Evol Biol 2:19. 2002
    ..Alternatively, this deceleration might be caused by non-transitive competitive interactions, in particular such that the measured advantage of later genotypes relative to earlier ones would be greater if they competed directly...
  67. ncbi The rise and fall of mutator bacteria
    A Giraud
    E9916, , , , 156 rue de Vaugirard, 75015 Paris, France
    Curr Opin Microbiol 4:582-5. 2001
    ..The evolution of bacterial populations may happen through alternating periods of high and low mutation rates. The cost and benefits of high mutation rates in the course of bacterial adaptive evolution are reviewed...
  68. pmc Task difficulty and performance induce diverse adaptive patterns in gain and shape of primary auditory cortical receptive fields
    Serin Atiani
    Neuroscience and Cognitive Sciences Program, University of Maryland, College Park, MD 20742, USA
    Neuron 61:467-80. 2009
    ..These adaptive STRF changes were largest in high-performance sessions, confirming a close correlation with behavior...
  69. pmc Adaptations to submarine hydrothermal environments exemplified by the genome of Nautilia profundicola
    Barbara J Campbell
    University of Delaware, Lewes, Delaware, USA
    PLoS Genet 5:e1000362. 2009
    ....
  70. ncbi Fundamental evolutionary limits in ecological traits drive Drosophila species distributions
    Vanessa Kellermann
    Centre for Environmental Stress and Adaptation Research, Department of Genetics, University of Melbourne, Parkville, Melbourne 3010, Australia
    Science 325:1244-6. 2009
    ..We predict that such species are likely to be constrained in their evolutionary responses to future climate changes...
  71. ncbi Persistence of motor adaptation during constrained, multi-joint, arm movements
    R A Scheidt
    Department of Biomedical Engineering, Northwestern University, Evanston, IL 60622, USA
    J Neurophysiol 84:853-62. 2000
    ....
  72. ncbi The fate of microbial mutators
    J Arjan G M de Visser
    Laboratory of Genetics, Wageningen University, Dreijenlaan 2, 6703 HA Wageningen, The Netherlands
    Microbiology 148:1247-52. 2002
  73. pmc The genome of Rhizobium leguminosarum has recognizable core and accessory components
    J Peter W Young
    Department of Biology, University of York, York, UK
    Genome Biol 7:R34. 2006
    ..We have sequenced the genome of R. leguminosarum biovar viciae strain 3841...
  74. ncbi Prism adaptation during walking generalizes to reaching and requires the cerebellum
    Susanne M Morton
    Kennedy Krieger Institute Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurophysiol 92:2497-509. 2004
    ..In contrast, prism adaptation during isolated movements of the limbs is probably recalibrated by effector-specific mechanisms. The cerebellum is an essential component in the network for both types of prism adaptation...
  75. ncbi Auditory-visual integration during multimodal object recognition in humans: a behavioral and electrophysiological study
    M H Giard
    INSERM U280, 151, cours Albert Thomas, F 69424 Lyon Cedex 03, France
    J Cogn Neurosci 11:473-90. 1999
    ....
  76. ncbi Hybridization and adaptive mate choice in flycatchers
    T Veen
    Department of Animal Ecology, Evolutionary Biology Centre, Uppsala University, SE-752 36 Uppsala, Sweden
    Nature 411:45-50. 2001
    ..Apparent hybridization may thus represent adaptive mate choice under some circumstances...
  77. pmc Rapid, local adaptation of zooplankton behavior to changes in predation pressure in the absence of neutral genetic changes
    C Cousyn
    Laboratory of Aquatic Ecology, Katholieke Universiteit Leuven, Ch. De Beriotstraat 32, B-3000 Leuven, Belgium
    Proc Natl Acad Sci U S A 98:6256-60. 2001
    ....
  78. pmc Parallel genetic evolution within and between bacteriophage species of varying degrees of divergence
    Jonathan P Bollback
    Department of Biology, University of Copenhagen, Copenhagen, Denmark
    Genetics 181:225-34. 2009
    ....
  79. ncbi Evolutionary capacitance as a general feature of complex gene networks
    Aviv Bergman
    Department of Biological Sciences, Stanford University, Stanford, California 94305 5020, USA
    Nature 424:549-52. 2003
    ..Thus, there might exist a large class of evolutionary capacitors whose effects on phenotypic variation complement the systemic, environment-induced effects of Hsp90...
  80. pmc The viral polymerase mediates adaptation of an avian influenza virus to a mammalian host
    G Gabriel
    Institut fur Virologie, Universitätsklinikum Giessen und Marburg, D 35033 Marburg, Germany
    Proc Natl Acad Sci U S A 102:18590-5. 2005
    ..These activity-enhancing mutations of the viral polymerase complex demonstrate convergent evolution in nature and, therefore, may be a prerequisite for adaptation to a new host paving the way for new pandemic viruses...
  81. ncbi Orientation-specific adaptation in human visual cortex
    Geoffrey M Boynton
    The Salk Institute, La Jolla, California 92037 1099, USA
    J Neurosci 23:8781-7. 2003
    ....
  82. pmc Altered levels of proline dehydrogenase cause hypersensitivity to proline and its analogs in Arabidopsis
    Srikrishnan Mani
    Vakgroep Moleculaire Genetica, Departement Plantengenetica, Vlaams Interuniversitair Instituut voor Biotechnologie, Universiteit Gent, K L Ledeganckstraat 35, B 9000 Gent, Belgium
    Plant Physiol 128:73-83. 2002
    ..These findings demonstrate that altered At-PDH levels lead to weakly modified free Pro accumulation with a limited impact on plant development and growth, suggesting a tight control of Pro homeostasis and/or gene redundancy...
  83. ncbi HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia
    Jung whan Kim
    Graduate Program of Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cell Metab 3:177-85. 2006
    ..These studies reveal a hypoxia-induced metabolic switch that shunts glucose metabolites from the mitochondria to glycolysis to maintain ATP production and to prevent toxic ROS production...
  84. ncbi Physiological bases of mosquito ecology
    Hans Briegel
    Institute of Zoology, University of Zurich, Winterthurerstr 190, CH 8057 Zurich, Switzerland
    J Vector Ecol 28:1-11. 2003
    ..These studies led to the recognition of distinctly different physiological strategies, for which the term "physiotype" has been coined, providing a basis for understanding the different ecotypes...
  85. pmc Reach adaptation: what determines whether we learn an internal model of the tool or adapt the model of our arm?
    Joann Kluzik
    Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    J Neurophysiol 100:1455-64. 2008
    ..Gradual changes in the tool's dynamics increased the extent to which the nervous system recalibrated the model of the subject's own arm...
  86. pmc The repertoire and dynamics of evolutionary adaptations to controlled nutrient-limited environments in yeast
    David Gresham
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA
    PLoS Genet 4:e1000303. 2008
    ..Thus, in addition to answering basic mechanistic questions about evolutionary mechanisms, our work suggests that experimental evolution can also shed light on the function and regulation of individual metabolic pathways...
  87. pmc African cichlid fish: a model system in adaptive radiation research
    Ole Seehausen
    Department of Aquatic Ecology and Evolution, Institute of Zoology, University of Bern, Switzerland
    Proc Biol Sci 273:1987-98. 2006
    ....
  88. ncbi What can we learn from resource pulses?
    Louie H Yang
    Section of Evolution and Ecology, University of California, One Shields Avenue, Davis, California 95616, USA
    Ecology 89:621-34. 2008
    ..We suggest that the study of resource pulses provides opportunities to understand the dynamics of many specific systems, and may also contribute to broader ecological questions at individual, population, and community levels...
  89. doi A systems view of nitrogen nutrient and metabolite responses in Arabidopsis
    Elena A Vidal
    Departamento de Genetica Molecular y Microbiologia, Pontificia Universidad Catolica de Chile, Alameda 340, Santiago, Chile
    Curr Opin Plant Biol 11:521-9. 2008
    ..We discuss recent advances in this direction...
  90. doi Capsule enlargement in Cryptococcus neoformans confers resistance to oxidative stress suggesting a mechanism for intracellular survival
    Oscar Zaragoza
    Servicio de Micologia, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Carretera Majadahonda Pozuelo, Km 2, Majadahonda, 28220, Madrid, Spain
    Cell Microbiol 10:2043-57. 2008
    ..neoformans cells produced resistance to phagocytosis. Our results suggest that capsular enlargement is a mechanism that enhances C. neoformans survival when ingested by phagocytic cells...
  91. ncbi Neuroimaging studies of priming
    R N A Henson
    Institute of Cognitive Neuroscience, University College London, London WC1N 3AR, UK
    Prog Neurobiol 70:53-81. 2003
    ..Interpretation of the findings is not always clear-cut, however, given potential confounding factors such as explicit memory, and several recommendations are made for future neuroimaging studies of priming...
  92. ncbi Long-lasting amelioration of visuospatial neglect by prism adaptation
    Francesca Frassinetti
    Dipartimento di Psicologia, Universita degli Studi di Bologna, Bologna, Italy
    Brain 125:608-23. 2002
    ..In conclusion, these findings show that prism adaptation is a productive way of achieving long-lasting improvements in neglect treatment...
  93. doi Evolution of metal hyperaccumulation required cis-regulatory changes and triplication of HMA4
    Marc Hanikenne
    Max Planck Institute of Molecular Plant Physiology, D 14476 Potsdam, Germany
    Nature 453:391-5. 2008
    ..The elucidation of a natural strategy for metal hyperaccumulation enables the rational design of technologies for the clean-up of metal-contaminated soils and for bio-fortification...
  94. ncbi Prism adaptation and unilateral neglect: review and analysis
    Gordon M Redding
    Department of Psychology, Illinois State University, Campus Box 4620, Normal, IL 61790 4620, USA
    Neuropsychologia 44:1-20. 2006
    ..Investigation of therapeutic prism adaptation requires methods that permit identification of both the calibration dysfunction and ameliorating realignment...
  95. pmc The dynamics of adaptation on correlated fitness landscapes
    Sergey Kryazhimskiy
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 106:18638-43. 2009
    ..Applying these methods to data from a long-term experiment, we infer the sign and strength of epistasis among beneficial mutations in the Escherichia coli genome...
  96. ncbi Odorant-specific adaptation pathways generate olfactory plasticity in C. elegans
    H A Colbert
    Department of Anatomy, University of California, San Francisco 94143 0452, USA
    Neuron 14:803-12. 1995
    ..Mutations in adp-1 and osm-9 do not diminish the ability of unadapted animals to respond to odorants, indicating that odorant sensation and odorant adaptation are distinct processes...
  97. pmc Decreasing xanthine oxidase-mediated oxidative stress prevents useful cellular adaptations to exercise in rats
    Mari Carmen Gomez-Cabrera
    Catholic University of Valencia, Spain
    J Physiol 567:113-20. 2005
    ....
  98. pmc A mutant of the Arabidopsis phosphate transporter PHT1;1 displays enhanced arsenic accumulation
    Pablo Catarecha
    Departamento de Genética Molecular de Plantas, Centro Nacional de Biotecnologia, Consejo Superior de Investigaciones Cientificas, Cantoblanco, E 28049 Madrid, Spain
    Plant Cell 19:1123-33. 2007
    ..Furthermore, the repression effect of As(V) on Pi starvation responses may reflect a regulatory mechanism to protect plants from the extreme toxicity of arsenic...
  99. pmc Adaptation and incipient sympatric speciation of Bacillus simplex under microclimatic contrast at "Evolution Canyons" I and II, Israel
    Johannes Sikorski
    Institute of Evolution, International Graduate Center of Evolution, University of Haifa, Haifa 31905, Israel
    Proc Natl Acad Sci U S A 102:15924-9. 2005
    ..We conclude that, despite different biology, prokaryotes, like sexually reproducing eukaryotes, may consist of true species and parallel ecological speciation in eukaryotes...
  100. ncbi Prism adaptation can improve contralesional tactile perception in neglect
    A Maravita
    Institute of Cognitive Neuroscience, University College, London, UK
    Neurology 60:1829-31. 2003
    ..This finding suggests a potential role for prismatic adaptation in the rehabilitation of multiple sensory modalities in patients with neglect...
  101. ncbi Prism adaptation in the rehabilitation of patients with visuo-spatial cognitive disorders
    Laure Pisella
    INSERM, U 534, Espace et Action, Bron, France
    Curr Opin Neurol 19:534-42. 2006
    ..The clinical outcome of prism adaptation highlights the need for a theoretical reconsideration of some previous stances to neurological rehabilitation...

Research Grants82

  1. NEUROIMMUNOMODULATION WITHIN THE EYE
    Andrew Taylor; Fiscal Year: 2006
    The eye normally possesses a unique physiological adaptation that regionally modifies the expression of immunity. This physiological adaptation is part of ocular immune privilege...
  2. MECHANISMS OF EXERCISE INDUCED ASTHMA IN HUMANS
    Kenneth Beck; Fiscal Year: 1999
    ..In addition, results from these studies may suggest therapies to improve airway function, particularly as related to exercise, in asthmatics. ..
  3. MECHANISMS OF EXERCISE INDUCED ASTHMA IN HUMANS
    Kenneth Beck; Fiscal Year: 2000
    ..In addition, results from these studies may suggest therapies to improve airway function, particularly as related to exercise, in asthmatics. ..
  4. Plasticity of nTS output neurons in acute and chronic hypoxia
    DAVID DOUGLAS KLINE; Fiscal Year: 2010
    ..This will be done in a model of OSA with the expectation of understanding potential therapeutic interventions. ..
  5. MODAFINIL FOR PERFORMANCE IMPAIRING SLEEPINESS ASSO. W NIGHT SHIFT WORK
    David Dinges; Fiscal Year: 2000
    ..abstract_text> ..
  6. Fetal/adult cerebral/pulmonary artery BK channel adaptat
    DAVID HESSINGER; Fiscal Year: 2005
    ..abstract_text> ..
  7. ARACHIDONATE LIPOXYGENASE ACTIVITIES IN HUMAN PREGNANCY
    Murray Mitchell; Fiscal Year: 1990
    ..Hence, more effective approaches to the management of such pregnancies may be developed...
  8. Prepregnancy Phenotype and Predisposition to Preeclampsia
    IRA MARK BERNSTEIN; Fiscal Year: 2010
    ..In addition, we are looking to understand the influence of pregnancy- specific, physiologic adaptations to the pathophysiologic associations of preeclampsia in a group of women at risk for developing preeclampsia. ..
  9. Spike After-Potentials of Oxytocin Cells in Lactation
    Ryoichi Teruyama; Fiscal Year: 2005
    My research interest has been focused on the physiological adaptation of animals to their different reproductive states...
  10. Spike After-Potentials of Oxytocin Cells in Lactation
    Ryoichi Teruyama; Fiscal Year: 2004
    My research interest has been focused on the physiological adaptation of animals to their different reproductive states...
  11. Mechanisms of Hemoglobin Adaptation to Hypoxia in High-altitude Rodents
    Jay F Storz; Fiscal Year: 2011
    The purpose of the proposed research project is to elucidate the molecular basis of physiological adaptation to high-altitude hypoxia, a condition resulting from a reduced supply of oxygen to the cells of respiring tissues...
  12. Mechanisms of Hemoglobin Adaptation to Hypoxia in High-altitude Rodents
    JAY STORZ; Fiscal Year: 2009
    The purpose of the proposed research project is to elucidate the molecular basis of physiological adaptation to high-altitude hypoxia, a condition resulting from a reduced supply of oxygen to the cells of respiring tissues...
  13. Mechanisms of Hemoglobin Adaptation to Hypoxia in High-altitude Rodents
    Jay F Storz; Fiscal Year: 2010
    The purpose of the proposed research project is to elucidate the molecular basis of physiological adaptation to high-altitude hypoxia, a condition resulting from a reduced supply of oxygen to the cells of respiring tissues...
  14. Mechanisms of Hemoglobin Adaptation to Hypoxia in High-altitude Rodents
    Jay F Storz; Fiscal Year: 2010
    The purpose of the proposed research project is to elucidate the molecular basis of physiological adaptation to high-altitude hypoxia, a condition resulting from a reduced supply of oxygen to the cells of respiring tissues...
  15. Mechanisms of Hemoglobin Adaptation to Hypoxia in High-altitude Rodents
    JAY STORZ; Fiscal Year: 2009
    The purpose of the proposed research project is to elucidate the molecular basis of physiological adaptation to high-altitude hypoxia, a condition resulting from a reduced supply of oxygen to the cells of respiring tissues...
  16. Role of phase-variable DNA methylase in virulence of Haemophilus influenzae
    Arnold Smith; Fiscal Year: 2007
    ..is common in clinical isolates and affects pathogenesis will provide the basis for future studies on the physiological adaptation of bacteria to different anatomic niches within the human host...
  17. Role of phase-variable DNA methylase in virulence of Haemophilus influenzae
    Arnold Smith; Fiscal Year: 2007
    ..is common in clinical isolates and affects pathogenesis will provide the basis for future studies on the physiological adaptation of bacteria to different anatomic niches within the human host...
  18. Identification of Relaxin Receptor Antagonists
    Sheau Yu Hsu; Fiscal Year: 2004
    ..Thus, relaxin plays a significant role in the overall regulation of physiological adaptation during pregnancy...
  19. Compartmental analysis of proteomic biomarkers during intra-uterine infections
    PETA LOUISE GRIGSBY; Fiscal Year: 2010
    ..Quantitative cultures and PCR for ureaplasmas will be performed on amniotic fluid, blood and fetal tissues. ..
  20. Identification of Relaxin Receptor Antagonists
    Sheau Yu Hsu; Fiscal Year: 2005
    ..Thus, relaxin plays a significant role in the overall regulation of physiological adaptation during pregnancy...
  21. Compartmental analysis of proteomic biomarkers during intra-uterine infections
    PETA GRIGSBY; Fiscal Year: 2009
    ..Quantitative cultures and PCR for ureaplasmas will be performed on amniotic fluid, blood and fetal tissues. ..
  22. Uterine vascular responses to pregnancy and hypoxemia
    Lubo Zhang; Fiscal Year: 2005
    ..abstract_text> ..
  23. Antibiotic pressure and selection of TCA cycle mutants in Staphylococcus epidermi
    PAUL FEY; Fiscal Year: 2009
    ..6 log10 compared to wild type. Therefore, the loss of TCA cycle activity represents a physiological adaptation of the bacterium to an environment where antibiotic pressure is prevalent...
  24. Antibiotic pressure and selection of TCA cycle mutants in Staphylococcus epidermi
    Paul D Fey; Fiscal Year: 2010
    ..6 log10 compared to wild type. Therefore, the loss of TCA cycle activity represents a physiological adaptation of the bacterium to an environment where antibiotic pressure is prevalent...
  25. Imprint Osmoregulation/Maternally-Dehydrated Offspring
    Mina Desai; Fiscal Year: 2005
    ..We will determine the molecular and cellular mechanism(s) and peripheral renal AVP receptor changes. Finally, we will delineate the critical period during which imprinting of the AVP/osmoregulatory pathway occurs. ..
  26. Imprint Osmoregulation/Maternally-Dehydrated Offspring
    Mina Desai; Fiscal Year: 2006
    ..We will determine the molecular and cellular mechanism(s) and peripheral renal AVP receptor changes. Finally, we will delineate the critical period during which imprinting of the AVP/osmoregulatory pathway occurs. ..
  27. Imprint Osmoregulation/Maternally-Dehydrated Offspring
    Mina Desai; Fiscal Year: 2007
    ..We will determine the molecular and cellular mechanism(s) and peripheral renal AVP receptor changes. Finally, we will delineate the critical period during which imprinting of the AVP/osmoregulatory pathway occurs. ..
  28. Imprint Osmoregulation/Maternally-Dehydrated Offspring
    Mina Desai; Fiscal Year: 2004
    ..We will determine the molecular and cellular mechanism(s) and peripheral renal AVP receptor changes. Finally, we will delineate the critical period during which imprinting of the AVP/osmoregulatory pathway occurs. ..
  29. Imprint Osmoregulation/Maternally-Dehydrated Offspring
    Mina Desai; Fiscal Year: 2003
    ..We will determine the molecular and cellular mechanism(s) and peripheral renal AVP receptor changes. Finally, we will delineate the critical period during which imprinting of the AVP/osmoregulatory pathway occurs. ..
  30. Physiological reactivity to acute stress during pregnancy
    LISA MICHELLE CHRISTIAN; Fiscal Year: 2010
    ..Moreover, limited information is available regarding effects of race on physiological adaptation to pregnancy...
  31. Physiological reactivity to acute stress during pregnancy
    Lisa Christian; Fiscal Year: 2009
    ..Moreover, limited information is available regarding effects of race on physiological adaptation to pregnancy...
  32. NEUROIMMUNOMODULATION WITHIN THE EYE
    Andrew Taylor; Fiscal Year: 2004
    The eye normally possesses a unique physiological adaptation that regionally modifies the expression of immunity. This physiological adaptation is part of ocular immune privilege...
  33. NEUROIMMUNOMODULATION WITHIN THE EYE
    Andrew Taylor; Fiscal Year: 2004
    The eye normally possesses a unique physiological adaptation that regionally modifies the expression of immunity. This physiological adaptation is part of ocular immune privilege...
  34. NEUROIMMUNOMODULATION WITHIN THE EYE
    Andrew Taylor; Fiscal Year: 2005
    The eye normally possesses a unique physiological adaptation that regionally modifies the expression of immunity. This physiological adaptation is part of ocular immune privilege...
  35. NEUROIMMUNOMODULATION WITHIN THE EYE
    Andrew Taylor; Fiscal Year: 2003
    The eye normally possesses a unique physiological adaptation that regionally modifies the expression of immunity. This physiological adaptation is part of ocular immune privilege...
  36. NEUROIMMUNOMODULATION WITHIN THE EYE
    Andrew Taylor; Fiscal Year: 2002
    The eye normally possesses a unique physiological adaptation that regionally modifies the expression of immunity. This physiological adaptation is part of ocular immune privilege...
  37. NEUROIMMUNOMODULATION WITHIN THE EYE
    Andrew Taylor; Fiscal Year: 1999
    The eye possesses a unique physiological adaptation that modifies the induction and expression of immunity within its tissues. This physiological adaptation is known as immune privilege. Normally the eye is an immune privileged site...
  38. Alcohol, Glial Gene Expression and the Heat Shock Pathway
    Neil L Harrison; Fiscal Year: 2010
    ..Microglia are the immune component of the brain and eliminate foreign invaders. Alcohol may alter the activity of all three types of glial cell by changing gene expression, and in doing so may harm nerve cells. ..
  39. Alcohol, Glial Gene Expression and the Heat Shock Pathway
    Neil Harrison; Fiscal Year: 2009
    ..Microglia are the immune component of the brain and eliminate foreign invaders. Alcohol may alter the activity of all three types of glial cell by changing gene expression, and in doing so may harm nerve cells. ..
  40. PHYSIOLOGICAL ADAPTATION TO SUSTAINED HYPO-OSMOLALITY
    Joseph Verbalis; Fiscal Year: 2001
    ..These studies should lead to an elucidation of the cellular mechanisms underlying one of the most basic and intriguing unanswered question about clinically hyponatremic disorders. ..
  41. Neuronal Responses to Effective Weight Loss Maintenance Strategies
    JASON R contact TREGELLAS; Fiscal Year: 2010
    ..By understanding the complex interactions between the brain response to eating and food cues and physiologic changes with these interventions we hope to be able to develop new strategies and/or interventions for sustained weight loss. ..
  42. PHYSIOLOGICAL ADAPTATION TO SUSTAINED HYPO-OSMOLALITY
    Joseph Verbalis; Fiscal Year: 2000
    ..These studies should lead to an elucidation of the cellular mechanisms underlying one of the most basic and intriguing unanswered question about clinically hyponatremic disorders. ..
  43. PHYSIOLOGICAL ADAPTATION TO SUSTAINED HYPO-OSMOLALITY
    Joseph Verbalis; Fiscal Year: 2002
    ..These studies should lead to an elucidation of the cellular mechanisms underlying one of the most basic and intriguing unanswered question about clinically hyponatremic disorders. ..
  44. PHYSIOLOGICAL ADAPTATION TO SUSTAINED HYPO-OSMOLALITY
    Joseph Verbalis; Fiscal Year: 1999
    ..These studies should lead to an elucidation of the cellular mechanisms underlying one of the most basic and intriguing unanswered question about clinically hyponatremic disorders. ..
  45. PHYSIOLOGICAL ADAPTATION TO SUSTAINED HYPOOSMOLALITY
    Joseph Verbalis; Fiscal Year: 1999
    ..These studies should lead to an elucidation of the cellular mechanisms underlying one of the most basic and intriguing unanswered question about clinically hyponatremic disorders. ..
  46. The Role of phosphoenolpyruvate carboxykinase and reactive oxygen species in the
    JASON EARL PODRABSKY; Fiscal Year: 2010
    ....
  47. ATRIAL NATRIURETIC PEPTIDE IN RENAL GROWTH
    ROBERT CHEVALIER; Fiscal Year: 1990
    ....
  48. ADAPTIVE MECHANISM TO LOW CALCIUM INTAKE DURING PUBERTY
    Steven Abrams; Fiscal Year: 2000
    ..Virtually no information is available regarding the physiological adaptation to these low intakes...
  49. ADAPTIVE MECHANISM TO LOW CALCIUM INTAKE DURING PUBERTY
    Steven Abrams; Fiscal Year: 1999
    ..Virtually no information is available regarding the physiological adaptation to these low intakes...
  50. OTOTOXICITY OF CHEMICAL ASPHYXIANTS AND NOISE
    Laurence Fechter; Fiscal Year: 1990
    ..injury to the auditory system requires an understanding of general mechanisms of ototoxicity, normal physiological adaptation of the cochlea to stress and basic metabolic requirements of the inner ear...
  51. NEUROENDOCRINE/IMMUNE INTERACTIONS: ROLE OF MELATONIN
    STEVEN YELLON; Fiscal Year: 2000
    ....
  52. NEUROENDOCRINE/IMMUNE INTERACTIONS: ROLE OF MELATONIN
    STEVEN YELLON; Fiscal Year: 2002
    ....
  53. NEUROENDOCRINE/IMMUNE INTERACTIONS: ROLE OF MELATONIN
    STEVEN YELLON; Fiscal Year: 2001
    ....
  54. NITRIC OXIDE SYNTHASE IN THE JUXTAGLOMERULAR APPARATUS
    CHRISTOPHER WILCOX; Fiscal Year: 2005
    ..abstract_text> ..
  55. NITRIC OXIDE SYNTHASE IN THE JUXTAGLOMERULAR APPARATUS
    CHRISTOPHER WILCOX; Fiscal Year: 2007
    ..abstract_text> ..
  56. NITRIC OXIDE SYNTHASE IN THE JUXTAGLOMERULAR APPARATUS
    CHRISTOPHER WILCOX; Fiscal Year: 2009
    ..abstract_text> ..
  57. NITRIC OXIDE SYNTHASE IN THE JUXTAGLOMERULAR APPARATUS
    CHRISTOPHER WILCOX; Fiscal Year: 2006
    ..abstract_text> ..
  58. INFLUENCES ON STABILITY FOLLOWING ORTHOGNATHIC SURGERY
    William Proffit; Fiscal Year: 1993
    ..The data also can provide a better understanding of the etiology of facial deformity problems by illustrating the effect of changes in humans...
  59. PEROMYSCUS LABORATORY MODELS FOR BIOMEDICAL RESEARCH
    Gabor Szalai; Fiscal Year: 2012
    ..PGSC provides animals for a variety of fields, including human infectious disease, behavioral studies, physiological adaptation, and genetic studies...
  60. PEROMYSCUS LABORATORY MODELS FOR BIOMEDICAL RESEARCH
    Gabor Szalai; Fiscal Year: 2010
    ..PGSC provides animals for a variety of fields, including human infectious disease, behavioral studies, physiological adaptation, and genetic studies...
  61. Functional genomics of molluscan schistosome development
    TIMOTHY YOSHINO; Fiscal Year: 2009
    ..Results of this work may lead to novel strategies for controlling infections within the snail host by disrupting specific larval development-dependent genes or their products. ..
  62. Functional genomics of molluscan schistosome development
    TIMOTHY YOSHINO; Fiscal Year: 2007
    ..Results of this work may lead to novel strategies for controlling infections within the snail host by disrupting specific larval development-dependent genes or their products. ..
  63. Functional genomics of molluscan schistosome development
    TIMOTHY YOSHINO; Fiscal Year: 2006
    ..Results of this work may lead to novel strategies for controlling infections within the snail host by disrupting specific larval development-dependent genes or their products. ..
  64. Functional genomics of molluscan schistosome development
    TIMOTHY YOSHINO; Fiscal Year: 2005
    ..Results of this work may lead to novel strategies for controlling infections within the snail host by disrupting specific larval development-dependent genes or their products. ..
  65. PEROMYSCUS LABORATORY MODELS FOR BIOMEDICAL RESEARCH
    Michael Felder; Fiscal Year: 2009
    ..PGSC provides animals for a variety of fields, including human infectious disease, behavioral studies, physiological adaptation, and genetic studies...
  66. PEROMYSCUS LABORATORY MODELS FOR BIOMEDICAL RESEARCH
    Michael Felder; Fiscal Year: 2009
    ..PGSC provides animals for a variety of fields, including human infectious disease, behavioral studies, physiological adaptation, and genetic studies...
  67. CENTRAL CONTROL OF OXYTOCIN RELEASE DURING GESTATION
    STEVEN BEALER; Fiscal Year: 2005
    ..abstract_text> ..
  68. CENTRAL CONTROL OF OXYTOCIN RELEASE DURING GESTATION
    STEVEN BEALER; Fiscal Year: 2006
    ..abstract_text> ..
  69. CENTRAL CONTROL OF OXYTOCIN RELEASE DURING GESTATION
    STEVEN BEALER; Fiscal Year: 2007
    ..abstract_text> ..
  70. SPINAL PLASTICITY OF A CORRECTIVE KINEMATIC RESPONSE
    V Edgerton; Fiscal Year: 2007
    ..abstract_text> ..
  71. SPINAL PLASTICITY OF A CORRECTIVE KINEMATIC RESPONSE
    V Edgerton; Fiscal Year: 2005
    ..abstract_text> ..
  72. Outcomes of Delayed Cord Clamping in VLBW Infants
    Judith Mercer; Fiscal Year: 2003
    ..These studies will establish if there is enough evidence to support the practice of delayed cord clamping in preterm infants. This project will provide the foundation for further research in larger preterm and term infants. ..
  73. Outcomes of Delayed Cord Clamping in VLBW Infants
    Judith Mercer; Fiscal Year: 2005
    ..These studies will establish if there is enough evidence to support the practice of delayed cord clamping in preterm infants. This project will provide the foundation for further research in larger preterm and term infants. ..
  74. SPINAL PLASTICITY OF A CORRECTIVE KINEMATIC RESPONSE
    V Edgerton; Fiscal Year: 2003
    ..abstract_text> ..
  75. Outcomes of Delayed Cord Clamping in VLBW Infants
    Judith Mercer; Fiscal Year: 2004
    ..These studies will establish if there is enough evidence to support the practice of delayed cord clamping in preterm infants. This project will provide the foundation for further research in larger preterm and term infants. ..
  76. RENAL ANGIOTENSIN II RECEPTOR AND SODIUM INTAKE
    Donna Wang; Fiscal Year: 1999
    ..the nephron, and will enable us to understand the control of AT1 receptor expression in the coordinated physiological adaptation to altered sodium intake...