physiological adaptation

Summary

Top Publications

  1. ncbi Preload maintenance and the left ventricular response to prolonged exercise in men
    E A Dawson
    The Copenhagen Muscle Research Center, Department of Anaesthesia, Rigshospitalet, Blegdamsvej 9, DK 2100, Copenhagen Ø, Denmark
    Exp Physiol 92:383-90. 2007
  2. ncbi OsDREB genes in rice, Oryza sativa L., encode transcription activators that function in drought-, high-salt- and cold-responsive gene expression
    Joseph G Dubouzet
    Biological Resources Division, Japan International Research Center for Agricultural Sciences (JIRCAS, 1-1 Ohwashi, Tsukuba, Ibaraki 305-8686, Japan
    Plant J 33:751-63. 2003
  3. ncbi Interacting adaptive processes with different timescales underlie short-term motor learning
    Maurice A Smith
    Division of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA
    PLoS Biol 4:e179. 2006
  4. ncbi Escherichia coli acid resistance: tales of an amateur acidophile
    John W Foster
    Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile, Alabama 36695, USA
    Nat Rev Microbiol 2:898-907. 2004
  5. ncbi Impacts of climate warming on terrestrial ectotherms across latitude
    Curtis A Deutsch
    Program on Climate Change and Department of Oceanography and Department of Biology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 105:6668-72. 2008
  6. ncbi Quantifying generalization from trial-by-trial behavior of adaptive systems that learn with basis functions: theory and experiments in human motor control
    Opher Donchin
    Laboratory for Computational Motor Control, Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, Maryland 21205 2195, USA
    J Neurosci 23:9032-45. 2003
  7. ncbi Introduced species and their missing parasites
    Mark E Torchin
    Marine Science Institute and Department of Ecology, Evolution and Marine Biology, University of California, Santa Barbara, California 93106, USA
    Nature 421:628-30. 2003
  8. ncbi Arabidopsis AtMYC2 (bHLH) and AtMYB2 (MYB) function as transcriptional activators in abscisic acid signaling
    Hiroshi Abe
    Biological Resources Division, Japan International Research Center for Agricultural Sciences, 1 1 Ohwashi, Tsukuba, Ibaraki 305 8686, Japan
    Plant Cell 15:63-78. 2003
  9. ncbi Cerebellar contributions to adaptive control of saccades in humans
    Minnan Xu-Wilson
    Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 29:12930-9. 2009
  10. ncbi Adaptation and the cost of complexity
    H A Orr
    Department of Biology, University of Rochester, New York 14627, USA
    Evolution 54:13-20. 2000

Detail Information

Publications266 found, 100 shown here

  1. ncbi Preload maintenance and the left ventricular response to prolonged exercise in men
    E A Dawson
    The Copenhagen Muscle Research Center, Department of Anaesthesia, Rigshospitalet, Blegdamsvej 9, DK 2100, Copenhagen Ø, Denmark
    Exp Physiol 92:383-90. 2007
    ..Three hours of semi-supine cycling resulted in no evidence of a depression in left ventricular systolic function, while left ventricular diastolic function declined postexercise...
  2. ncbi OsDREB genes in rice, Oryza sativa L., encode transcription activators that function in drought-, high-salt- and cold-responsive gene expression
    Joseph G Dubouzet
    Biological Resources Division, Japan International Research Center for Agricultural Sciences (JIRCAS, 1-1 Ohwashi, Tsukuba, Ibaraki 305-8686, Japan
    Plant J 33:751-63. 2003
    ..OsDREB1A is potentially useful for producing transgenic monocots that are tolerant to drought, high-salt, and/or cold stresses...
  3. ncbi Interacting adaptive processes with different timescales underlie short-term motor learning
    Maurice A Smith
    Division of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA
    PLoS Biol 4:e179. 2006
    ..Our results suggest that motor adaptation depends on at least two distinct neural systems that have different sensitivity to error and retain information at different rates...
  4. ncbi Escherichia coli acid resistance: tales of an amateur acidophile
    John W Foster
    Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile, Alabama 36695, USA
    Nat Rev Microbiol 2:898-907. 2004
    ..Surprisingly, certain microorganisms that grow at neutral pH have elegantly regulated systems that enable survival during excursions into acidic environments. The best-characterized acid-resistance system is found in E. coli...
  5. ncbi Impacts of climate warming on terrestrial ectotherms across latitude
    Curtis A Deutsch
    Program on Climate Change and Department of Oceanography and Department of Biology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 105:6668-72. 2008
    ..Our analyses imply that, in the absence of ameliorating factors such as migration and adaptation, the greatest extinction risks from global warming may be in the tropics, where biological diversity is also greatest...
  6. ncbi Quantifying generalization from trial-by-trial behavior of adaptive systems that learn with basis functions: theory and experiments in human motor control
    Opher Donchin
    Laboratory for Computational Motor Control, Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, Maryland 21205 2195, USA
    J Neurosci 23:9032-45. 2003
    ....
  7. ncbi Introduced species and their missing parasites
    Mark E Torchin
    Marine Science Institute and Department of Ecology, Evolution and Marine Biology, University of California, Santa Barbara, California 93106, USA
    Nature 421:628-30. 2003
    ....
  8. ncbi Arabidopsis AtMYC2 (bHLH) and AtMYB2 (MYB) function as transcriptional activators in abscisic acid signaling
    Hiroshi Abe
    Biological Resources Division, Japan International Research Center for Agricultural Sciences, 1 1 Ohwashi, Tsukuba, Ibaraki 305 8686, Japan
    Plant Cell 15:63-78. 2003
    ..These results indicate that both AtMYC2 and AtMYB2 proteins function as transcriptional activators in ABA-inducible gene expression under drought stress in plants...
  9. ncbi Cerebellar contributions to adaptive control of saccades in humans
    Minnan Xu-Wilson
    Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 29:12930-9. 2009
    ....
  10. ncbi Adaptation and the cost of complexity
    H A Orr
    Department of Biology, University of Rochester, New York 14627, USA
    Evolution 54:13-20. 2000
    ..The present results also suggest that one can define an effective number of dimensions characterizing an adapting species...
  11. ncbi Bacterial biofilms: from the natural environment to infectious diseases
    Luanne Hall-Stoodley
    Department of Veterinary Molecular Microbiology, Departments of Microbiology and Civil Engineering, Center for Biofilm Engineering, Montana State University, Bozeman, Montana, USA
    Nat Rev Microbiol 2:95-108. 2004
    ..The implications of these survival and propagative mechanisms in the context of both the natural environment and infectious diseases are discussed in this review...
  12. ncbi Duration-dependent FMRI adaptation and distributed viewer-centered face representation in human visual cortex
    Fang Fang
    Department of Psychology, University of Minnesota, 75 East River Parkway, Minneapolis, MN 55455, USA
    Cereb Cortex 17:1402-11. 2007
    ..Our findings suggest that long- and short-term fMRI adaptations may reflect selective properties of different neuronal mechanisms...
  13. ncbi Prototype-referenced shape encoding revealed by high-level aftereffects
    D A Leopold
    , , Germany
    Nat Neurosci 4:89-94. 2001
    ..The results suggest that the encoding of faces and other complex patterns draws upon contrastive neural mechanisms that reference the central tendency of the stimulus category...
  14. ncbi Fundamental evolutionary limits in ecological traits drive Drosophila species distributions
    Vanessa Kellermann
    Centre for Environmental Stress and Adaptation Research, Department of Genetics, University of Melbourne, Parkville, Melbourne 3010, Australia
    Science 325:1244-6. 2009
    ..We predict that such species are likely to be constrained in their evolutionary responses to future climate changes...
  15. ncbi Understanding the adaptive growth strategy of Lactobacillus plantarum by in silico optimisation
    Bas Teusink
    Top Institute Food and Nutrition WCFS, Wageningen, The Netherlands
    PLoS Comput Biol 5:e1000410. 2009
    ..Hence, these results provide thorough understanding of adaptive evolution, allowing in silico predictions of the resulting flux states, provided that the selective growth conditions favor yield optimization as the winning strategy...
  16. ncbi Constraint to adaptive evolution in response to global warming
    J R Etterson
    University of Minnesota, Department of Ecology, Evolution and Behavior, Minnesota Center for Community Genetics, 1987 Upper Buford Circle, St Paul, MN 55108, USA
    Science 294:151-4. 2001
    ..Predicted rates of evolutionary response are much slower than the predicted rate of climate change...
  17. ncbi The fate of microbial mutators
    J Arjan G M de Visser
    Laboratory of Genetics, Wageningen University, Dreijenlaan 2, 6703 HA Wageningen, The Netherlands
    Microbiology 148:1247-52. 2002
  18. ncbi Regulatory and metabolic rewiring during laboratory evolution of ethanol tolerance in E. coli
    Hani Goodarzi
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Mol Syst Biol 6:378. 2010
    ..Remarkably, these laboratory-evolved strains, by and large, follow the same adaptive paths as inferred from our coarse-grained search of the fitness landscape...
  19. ncbi Persistence of motor adaptation during constrained, multi-joint, arm movements
    R A Scheidt
    Department of Biomedical Engineering, Northwestern University, Evanston, IL 60622, USA
    J Neurophysiol 84:853-62. 2000
    ....
  20. ncbi Task difficulty and performance induce diverse adaptive patterns in gain and shape of primary auditory cortical receptive fields
    Serin Atiani
    Neuroscience and Cognitive Sciences Program, University of Maryland, College Park, MD 20742, USA
    Neuron 61:467-80. 2009
    ..These adaptive STRF changes were largest in high-performance sessions, confirming a close correlation with behavior...
  21. ncbi Long-term experimental evolution in Escherichia coli. XI. Rejection of non-transitive interactions as cause of declining rate of adaptation
    J Arjan G M de Visser
    Laboratory of Genetics, Wageningen University, Arboretumlaan 4, 6703 BD Wageningen, The Netherlands
    BMC Evol Biol 2:19. 2002
    ..Alternatively, this deceleration might be caused by non-transitive competitive interactions, in particular such that the measured advantage of later genotypes relative to earlier ones would be greater if they competed directly...
  22. ncbi Evolution of a polyphenism by genetic accommodation
    Yuichiro Suzuki
    Department of Biology, Duke University, Durham, NC 27708, USA
    Science 311:650-2. 2006
    ..Evidently, mechanisms that regulate developmental hormones can mask genetic variation and act as evolutionary capacitors, facilitating the origin of novel adaptive phenotypes...
  23. ncbi Adaptations to submarine hydrothermal environments exemplified by the genome of Nautilia profundicola
    Barbara J Campbell
    University of Delaware, Lewes, Delaware, USA
    PLoS Genet 5:e1000362. 2009
    ....
  24. ncbi The rise and fall of mutator bacteria
    A Giraud
    E9916, , , , 156 rue de Vaugirard, 75015 Paris, France
    Curr Opin Microbiol 4:582-5. 2001
    ..The evolution of bacterial populations may happen through alternating periods of high and low mutation rates. The cost and benefits of high mutation rates in the course of bacterial adaptive evolution are reviewed...
  25. ncbi What can we learn from resource pulses?
    Louie H Yang
    Section of Evolution and Ecology, University of California, One Shields Avenue, Davis, California 95616, USA
    Ecology 89:621-34. 2008
    ..We suggest that the study of resource pulses provides opportunities to understand the dynamics of many specific systems, and may also contribute to broader ecological questions at individual, population, and community levels...
  26. ncbi Orientation-specific adaptation in human visual cortex
    Geoffrey M Boynton
    The Salk Institute, La Jolla, California 92037 1099, USA
    J Neurosci 23:8781-7. 2003
    ....
  27. ncbi Physiological bases of mosquito ecology
    Hans Briegel
    Institute of Zoology, , Winterthurerstr. 190, , Switzerland
    J Vector Ecol 28:1-11. 2003
    ..These studies led to the recognition of distinctly different physiological strategies, for which the term "physiotype" has been coined, providing a basis for understanding the different ecotypes...
  28. ncbi Capsule enlargement in Cryptococcus neoformans confers resistance to oxidative stress suggesting a mechanism for intracellular survival
    Oscar Zaragoza
    Servicio de Micologia, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Carretera Majadahonda Pozuelo, Km 2, Majadahonda, 28220, Madrid, Spain
    Cell Microbiol 10:2043-57. 2008
    ..neoformans cells produced resistance to phagocytosis. Our results suggest that capsular enlargement is a mechanism that enhances C. neoformans survival when ingested by phagocytic cells...
  29. ncbi The repertoire and dynamics of evolutionary adaptations to controlled nutrient-limited environments in yeast
    David Gresham
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA
    PLoS Genet 4:e1000303. 2008
    ..Thus, in addition to answering basic mechanistic questions about evolutionary mechanisms, our work suggests that experimental evolution can also shed light on the function and regulation of individual metabolic pathways...
  30. ncbi Altered levels of proline dehydrogenase cause hypersensitivity to proline and its analogs in Arabidopsis
    Srikrishnan Mani
    Vakgroep Moleculaire Genetica, Departement Plantengenetica, Vlaams Interuniversitair Instituut voor Biotechnologie, Universiteit Gent, K.L. Ledeganckstraat 35, B-9000 Gent, Belgium
    Plant Physiol 128:73-83. 2002
    ..These findings demonstrate that altered At-PDH levels lead to weakly modified free Pro accumulation with a limited impact on plant development and growth, suggesting a tight control of Pro homeostasis and/or gene redundancy...
  31. ncbi Neuroimaging studies of priming
    R N A Henson
    Institute of Cognitive Neuroscience, University College London, London WC1N 3AR, UK
    Prog Neurobiol 70:53-81. 2003
    ..Interpretation of the findings is not always clear-cut, however, given potential confounding factors such as explicit memory, and several recommendations are made for future neuroimaging studies of priming...
  32. ncbi Response of plant metabolism to too little oxygen
    Peter Geigenberger
    Max Planck Institute of Molecular Plant Physiology, Am Muhlenberg 1, 14476 Golm, Germany
    Curr Opin Plant Biol 6:247-56. 2003
    ..Recently, advances have been made in elucidating possible oxygen-sensing systems and regulatory components that are involved in these responses...
  33. ncbi Reach adaptation: what determines whether we learn an internal model of the tool or adapt the model of our arm?
    Joann Kluzik
    Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    J Neurophysiol 100:1455-64. 2008
    ..Gradual changes in the tool's dynamics increased the extent to which the nervous system recalibrated the model of the subject's own arm...
  34. ncbi A systems view of nitrogen nutrient and metabolite responses in Arabidopsis
    Elena A Vidal
    Departamento de Genetica Molecular y Microbiologia, Pontificia Universidad Catolica de Chile, Alameda 340, Santiago, Chile
    Curr Opin Plant Biol 11:521-9. 2008
    ..We discuss recent advances in this direction...
  35. ncbi African cichlid fish: a model system in adaptive radiation research
    Ole Seehausen
    Department of Aquatic Ecology and Evolution, Institute of Zoology, University of Bern, Switzerland
    Proc Biol Sci 273:1987-98. 2006
    ....
  36. ncbi HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia
    Jung whan Kim
    Graduate Program of Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cell Metab 3:177-85. 2006
    ..These studies reveal a hypoxia-induced metabolic switch that shunts glucose metabolites from the mitochondria to glycolysis to maintain ATP production and to prevent toxic ROS production...
  37. ncbi Prism adaptation can improve contralesional tactile perception in neglect
    A Maravita
    Institute of Cognitive Neuroscience, University College, London, UK
    Neurology 60:1829-31. 2003
    ..This finding suggests a potential role for prismatic adaptation in the rehabilitation of multiple sensory modalities in patients with neglect...
  38. ncbi Prism adaptation in the rehabilitation of patients with visuo-spatial cognitive disorders
    Laure Pisella
    INSERM, U 534, Espace et Action, Bron, France
    Curr Opin Neurol 19:534-42. 2006
    ..The use of prism adaptation therapy in neglect and other visuo-spatial disorders has just started to reveal its potential, both at a practical and theoretical level...
  39. ncbi Adaptation and incipient sympatric speciation of Bacillus simplex under microclimatic contrast at "Evolution Canyons" I and II, Israel
    Johannes Sikorski
    Institute of Evolution, International Graduate Center of Evolution, University of Haifa, Haifa 31905, Israel
    Proc Natl Acad Sci U S A 102:15924-9. 2005
    ..We conclude that, despite different biology, prokaryotes, like sexually reproducing eukaryotes, may consist of true species and parallel ecological speciation in eukaryotes...
  40. ncbi Prism adaptation and unilateral neglect: review and analysis
    Gordon M Redding
    Department of Psychology, Illinois State University, Campus Box 4620, Normal, IL 61790 4620, USA
    Neuropsychologia 44:1-20. 2006
    ..Investigation of therapeutic prism adaptation requires methods that permit identification of both the calibration dysfunction and ameliorating realignment...
  41. ncbi A mutant of the Arabidopsis phosphate transporter PHT1;1 displays enhanced arsenic accumulation
    Pablo Catarecha
    Departamento de Genética Molecular de Plantas, Centro Nacional de Biotecnologia, Consejo Superior de Investigaciones Cientificas, Cantoblanco, E 28049 Madrid, Spain
    Plant Cell 19:1123-33. 2007
    ..Furthermore, the repression effect of As(V) on Pi starvation responses may reflect a regulatory mechanism to protect plants from the extreme toxicity of arsenic...
  42. ncbi Decreasing xanthine oxidase-mediated oxidative stress prevents useful cellular adaptations to exercise in rats
    Mari Carmen Gomez-Cabrera
    Catholic University of Valencia, Spain
    J Physiol 567:113-20. 2005
    ....
  43. ncbi Long-lasting amelioration of visuospatial neglect by prism adaptation
    Francesca Frassinetti
    Dipartimento di Psicologia, Universita degli Studi di Bologna, Bologna, Italy
    Brain 125:608-23. 2002
    ..In conclusion, these findings show that prism adaptation is a productive way of achieving long-lasting improvements in neglect treatment...
  44. ncbi Parallel genetic evolution within and between bacteriophage species of varying degrees of divergence
    Jonathan P Bollback
    Department of Biology, University of Copenhagen, Copenhagen, Denmark
    Genetics 181:225-34. 2009
    ....
  45. ncbi Odorant-specific adaptation pathways generate olfactory plasticity in C. elegans
    H A Colbert
    Department of Anatomy, University of California, San Francisco 94143 0452, USA
    Neuron 14:803-12. 1995
    ..Mutations in adp-1 and osm-9 do not diminish the ability of unadapted animals to respond to odorants, indicating that odorant sensation and odorant adaptation are distinct processes...
  46. ncbi Minimal models of adapted neuronal response to in vivo-like input currents
    Giancarlo La Camera
    Institute of Physiology, University of Bern, CH 3012 Bern, Switzerland
    Neural Comput 16:2101-24. 2004
    ..Finally, we show how the stationary model can be used to predict the time-varying activity of a large population of adapting neurons...
  47. ncbi Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice
    Jiandie Lin
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 119:121-35. 2004
    ..These data illustrate a central role for PGC-1alpha in the control of energy metabolism but also reveal novel systemic compensatory mechanisms and pathogenic effects of impaired energy homeostasis...
  48. ncbi The dynamics of adaptation on correlated fitness landscapes
    Sergey Kryazhimskiy
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 106:18638-43. 2009
    ..Applying these methods to data from a long-term experiment, we infer the sign and strength of epistasis among beneficial mutations in the Escherichia coli genome...
  49. ncbi Evolution of metal hyperaccumulation required cis-regulatory changes and triplication of HMA4
    Marc Hanikenne
    Max Planck Institute of Molecular Plant Physiology, D 14476 Potsdam, Germany
    Nature 453:391-5. 2008
    ..The elucidation of a natural strategy for metal hyperaccumulation enables the rational design of technologies for the clean-up of metal-contaminated soils and for bio-fortification...
  50. ncbi Gene networks involved in drought stress response and tolerance
    Kazuo Shinozaki
    RIKEN Plant Science Center, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, 203 0045 Japan
    J Exp Bot 58:221-7. 2007
    ..A description is also provided of how various genes involved in stress tolerance were applied in genetic engineering of dehydration stress tolerance in transgenic Arabidopsis plants...
  51. ncbi Task-modulated "what" and "where" pathways in human auditory cortex
    Jyrki Ahveninen
    Harvard Medical School Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, CNY 149 13th Street, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 103:14608-13. 2006
    ..This finding suggests that selective-attention effects are feature-specific in the human nonprimary auditory cortex and that they arise from enhanced tuning of receptive fields of task-relevant neuronal populations...
  52. ncbi Short on phosphate: plant surveillance and countermeasures
    Carla A Ticconi
    Department of Plant Sciences, University of California-Davis, One Shields Avenue, Davis, CA 95616, USA
    Trends Plant Sci 9:548-55. 2004
    ..Recent studies have provided evidence for P(i) as a signaling molecule and initial insight into the coordination of P(i) deficiency responses at the cellular and molecular level...
  53. ncbi From molecular noise to behavioural variability in a single bacterium
    Ekaterina Korobkova
    The Institute for Biophysical Dynamics and the James Franck Institute, The University of Chicago, 5640 South Ellis Avenue, Chicago, Illinois 60637, USA
    Nature 428:574-8. 2004
    ..Small changes in the concentration of one key network component suppress temporal behavioural variability, suggesting that such variability is a selected property of this adaptive system...
  54. ncbi Lifespan extension of Drosophila melanogaster through hormesis by repeated mild heat stress
    Miriam J Hercus
    Aarhus Centre for Environmental Stress Research, Department of Ecology and Genetics, University of Aarhus, Ny Munkegade, Building 540, DK-8000 Aarhus C, Denmark
    Biogerontology 4:149-56. 2003
    ..The mild heat stress had no impact on egg viability. The mild heat stress exposures increased resistance to potentially lethal heat stress and levels of Hsp70 expression in heat-exposed flies were higher than those in controls...
  55. ncbi Evidence of adaptive divergence in plasticity: density- and site-dependent selection on shade-avoidance responses in Impatiens capensis
    K Donohue
    Department of Ecology and Evolutionary Biology, Brown University, Providence, Rhode Island 02912, USA
    Evolution 54:1956-68. 2000
    ..Selection on the measured characters contributed to local adaptation and fully accounted for fitness differences between populations in all treatments except the woodland site at natural density...
  56. ncbi Role of guanylate cyclase-activating proteins (GCAPs) in setting the flash sensitivity of rod photoreceptors
    A Mendez
    The Mary D Allen Laboratory for Vision Research, Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles 90089 9112, USA
    Proc Natl Acad Sci U S A 98:9948-53. 2001
    ..We conclude that GCAPs strongly regulate GC activity in mouse rods, decreasing the flash sensitivity in darkness and increasing the incremental flash sensitivity in bright steady light, thereby extending the rod's operating range...
  57. ncbi Representation of perceived object shape by the human lateral occipital complex
    Z Kourtzi
    Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 293:1506-9. 2001
    ..These data indicate that the LOC represents not simple image features, but rather higher level shape information...
  58. ncbi Recalibration of perceived time across sensory modalities
    James V M Hanson
    Department of Optometry, University of Bradford, Richmond Road, Bradford BD7 1DP, UK
    Exp Brain Res 185:347-52. 2008
    ..In light of these findings we suggest that a single supramodal mechanism may be responsible for the observed recalibration of multisensory perceived time...
  59. ncbi Shifting and scaling adaptation to dynamic stimuli in somatosensory cortex
    J A Garcia-Lazaro
    Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Building, Parks Road, Oxford, OX13PT, UK
    Eur J Neurosci 26:2359-68. 2007
    ..Using realistic single-neuron models, we go on to show that after-hyperpolarizing currents, such as those carried by K(Ca)(2+) channels, may be responsible for the threshold shifts, but not the slope changes...
  60. ncbi Population genomics of marine fishes: identifying adaptive variation in space and time
    Einar E Nielsen
    Technical University of Denmark, National Institute of Aquatic Resources, Vejlsøvej 39, Silkeborg, Denmark
    Mol Ecol 18:3128-50. 2009
    ....
  61. ncbi Mechanisms of plant desiccation tolerance
    F A Hoekstra
    Graduate School Experimental Plant Sciences, Laboratory of Plant Physiology, Wageningen University, Arboretumlaan 4, 6703 BD Wageningen, The Netherlands
    Trends Plant Sci 6:431-8. 2001
    ....
  62. ncbi Regulation of the Arabidopsis transcriptome by oxidative stress
    R Desikan
    Centre for Research in Plant Science, University of the West of England, Bristol, Coldharbour Lane, Bristol BS16 1QY, United Kingdom
    Plant Physiol 127:159-72. 2001
    ....
  63. ncbi Costs and benefits of high mutation rates: adaptive evolution of bacteria in the mouse gut
    A Giraud
    E9916, , , , 156 rue de Vaugirard, 75015 Paris, France
    Science 291:2606-8. 2001
    ..The short-term advantages and long-term disadvantages of mutator bacteria could account for their frequency in nature...
  64. ncbi The stroke volume response during or throughout 4-8 min of constant-power exercise that elicits VO2max
    Edward F Coyle
    J Appl Physiol 104:282-3; author reply 284-5. 2008
  65. ncbi Solving the Fick principle using whole body measurements can be used to discriminate ''central'' and ''peripheral'' adaptations to training
    Frederic N Daussin
    Eur J Appl Physiol 103:733-5; author reply 737-8. 2008
  66. ncbi American College of Sports Medicine position stand. Progression models in resistance training for healthy adults
    William J Kraemer
    Med Sci Sports Exerc 34:364-80. 2002
    ..In the interpretation of this position stand, as with prior ones, the recommendations should be viewed in context of the individual's target goals, physical capacity, and training status...
  67. ncbi Post-exercise leg and forearm flexor muscle cooling in humans attenuates endurance and resistance training effects on muscle performance and on circulatory adaptation
    Motoi Yamane
    Laboratory for Exercise Physiology and Biomechanics, Chukyo University, 101 Tokodachi, Kaizu cho Toyota, 470 0393, Aichi, Japan
    Eur J Appl Physiol 96:572-80. 2006
    ..This seems disadvantageous for training, in contrast to the beneficial combination of rest, ice, compression and elevation in the treatment of macroscopic musculo-tendinous damage...
  68. ncbi Control of heart rate variability by cardiac parasympathetic nerve activity during voluntary static exercise in humans with tetraplegia
    Makoto Takahashi
    Dept of Sports Medicine, Graduate School of Health Sciences, Hiroshima University, Minami Ku, Hiroshima 734 8551, Japan
    J Appl Physiol 103:1669-77. 2007
    ....
  69. ncbi Effect of endurance exercise training on Ca2+ calmodulin-dependent protein kinase II expression and signalling in skeletal muscle of humans
    Adam J Rose
    Copenhagen Muscle Research Centre, Department of Exercise and Sport Sciences, Section of Human Physiology, University of Copenhagen, Universitetsparken 13, Copenhagen, Denmark 2100
    J Physiol 583:785-95. 2007
    ..This may contribute to greater Ca(2+) mediated regulation during exercise and the altered muscle phenotype with training...
  70. ncbi Despite the large quantity of data on LV performance during exercise, basic data on left ventricular performance are conflicting
    Egil Henriksen
    J Appl Physiol 104:281-2; author reply 284-5. 2008
  71. ncbi Prolonged electrical muscle stimulation exercise improves strength and aerobic capacity in healthy sedentary adults
    Prithwish Banerjee
    Department of Academic Cardiology, University of Hull, Castle Hill Hospital, Cottingham, Kingston-upon-Hull, UK
    J Appl Physiol 99:2307-11. 2005
    ..05). These results suggest that EMS can be used in sedentary adults to improve physical fitness. It may provide a viable alternative to more conventional forms of exercise in this population...
  72. ncbi The occurrence of a VO2 drop after the achievement of a VO2 peak or VO2max plateau
    Veronique Louise Billat
    J Appl Physiol 104:283; author reply 284-5. 2008
  73. ncbi Endurance training, resistance training, body composition, or different disease states can lead to diverse adaptations in cardiac structure and/or function
    Chantal A Vella
    J Appl Physiol 104:282; author reply 284-5. 2008
  74. ncbi Point: Stroke volume does/does not decline during exercise at maximal effort in healthy individuals
    Jose Gonzalez-Alonso
    Centre for Sports Medicine and Human Performance Brunel University, Uxbridge Middlesex, United Kingdom
    J Appl Physiol 104:275-6; discussion 279-80. 2008
  75. ncbi PGC-1beta is downregulated by training in human skeletal muscle: no effect of training twice every second day vs. once daily on expression of the PGC-1 family
    Ole Hartvig Mortensen
    Centre of Inflammation and Metabolism, Department of Infectious Diseases, Rigshospitalet 7641, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Appl Physiol 103:1536-42. 2007
    ..In conclusion, there was no difference between training protocols on the acute exercise and training response of the PGC-1 family. However, training caused a decrease in PGC-1beta mRNA levels...
  76. ncbi Endurance performance is associated with the heart capacity to pump large blood volume to muscles
    Pierre Marie Lepretre
    J Appl Physiol 104:281; author reply 284-5. 2008
  77. ncbi Decrease or no decrease in the stroke volume of healthy humans approaching volitional exhaustion during large muscle mass exercise
    Alejandro Lucia
    J Appl Physiol 104:281; author reply 284-5. 2008
  78. ncbi Counterpoint: Stroke volume does not decline during exercise at maximal effort in healthy individuals
    Darren E R Warburton
    Cardiovascular Physiology and Rehabilitation Laboratory, Experimental Medicine Program, Faculty of Medicine, University of British Columbia, Vancouver, Canada
    J Appl Physiol 104:276-8; discussion 278-9. 2008
  79. ncbi The effects of creatine supplementation on cardiovascular, metabolic, and thermoregulatory responses during exercise in the heat in endurance-trained humans
    L P Kilduff
    Centre for Exercise Science and Medicine in the Institute of Biomedical and Life Sciences at the University of Glasgow, Glasgow, UK
    Int J Sport Nutr Exerc Metab 14:443-60. 2004
    ..3 +/- 4.9 min vs. 51.7 +/- 7.4 min, P = 0.031). Cr-induced hyperhydration can result in a more efficient thermoregulatory response during prolonged exercise in the heat...
  80. ncbi The concept of maximal lactate steady state: a bridge between biochemistry, physiology and sport science
    Veronique L Billat
    Sport Science Department, University of Evry Val d Essonne, Paris, France
    Sports Med 33:407-26. 2003
    ..However, lactate exchange and removal indirectly estimated with velocity constants of the individual blood lactate recovery has been reported to be related to time to exhaustion at maximal oxygen uptake...
  81. ncbi Resistance exercise training reduces plasma endothelin-1 concentration in healthy young humans
    Seiji Maeda
    Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba, Ibaraki, Japan
    J Cardiovasc Pharmacol 44:S443-6. 2004
    ....
  82. ncbi Effects of chronic NaHCO3 ingestion during interval training on changes to muscle buffer capacity, metabolism, and short-term endurance performance
    Johann Edge
    School of Human Movement and Exercise Science, The University of Western Australia, Perth, Australia
    J Appl Physiol 101:918-25. 2006
    ....
  83. ncbi Cost of transport is increased after cold exposure in Monodelphis domestica: training for inefficiency
    Paul J Schaeffer
    Department of Biological Sciences, Physiology and Functional Morphology Group, Northern Arizona University, Flagstaff, AZ 86011, USA
    J Exp Biol 208:3159-67. 2005
    ..However, linked to the dramatic shift in muscle properties is an equally dramatic increase in whole animal muscle energetics during locomotion, suggesting an uncoupled state, or 'training for inefficiency'...
  84. ncbi Long-term fat diet adaptation effects on performance, training capacity, and fat utilization
    Jørn Wulff Helge
    Copenhagen Muscle Research Centre, H S State Hospital, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Med Sci Sports Exerc 34:1499-504. 2002
    ....
  85. ncbi The Yo-Yo intermittent recovery test : a useful tool for evaluation of physical performance in intermittent sports
    Jens Bangsbo
    Institute of Exercise and Sport Sciences, University of Copenhagen, Copenhagen Muscle Research Centre, Copenhagen, Denmark
    Sports Med 38:37-51. 2008
    ..The Yo-Yo IR tests provide a simple and valid way to obtain important information of an individual's capacity to perform repeated intense exercise and to examine changes in performance...
  86. ncbi Nonexercise activity thermogenesis (NEAT): environment and biology
    James A Levine
    Endocrine Research Unit, Mayo Clinic, Rochester, MN 55905, USA
    Am J Physiol Endocrinol Metab 286:E675-85. 2004
    ..A scheme is described in this review in which NEAT corresponds to a carefully regulated "tank" of physical activity that is crucial for weight control...
  87. ncbi Regulation of mTOR by amino acids and resistance exercise in skeletal muscle
    L Deldicque
    Institut d éducation physique et de réadaptation, Universite Catholique de Louvain, Belgium
    Eur J Appl Physiol 94:1-10. 2005
    ..There appears to be a requirement for a minimal concentration of plasma insulin to stimulate muscle protein synthesis in response to resistance exercise and AA ingestion...
  88. ncbi Control of gene expression and mitochondrial biogenesis in the muscular adaptation to endurance exercise
    Anna-Maria Joseph
    Department of Biology, York University, Toronto, Ontario, Canada, M3J 1P3
    Essays Biochem 42:13-29. 2006
    ..An understanding of how exercise can produce this effect could help us decide whether exercise is beneficial for patients suffering from mitochondrial disorders, as well as a variety of metabolic diseases...
  89. ncbi Reactive oxygen species and redox-regulation of skeletal muscle adaptations to exercise
    Malcolm J Jackson
    School of Clinical Sciences, University of Liverpool Division of Metabolic and Cellular Medicine Liverpool L69 3GA, UK
    Philos Trans R Soc Lond B Biol Sci 360:2285-91. 2005
    ..These processes are also recognized to be modified during ageing and in some disease states, providing the potential that interventions affecting ROS activity may influence muscle function or viability in these situations...
  90. ncbi Interleukin-6 in acute exercise and training: what is the biological relevance?
    Christian P Fischer
    Centre of Inflammation and Metabolism, Department of Infectious Diseases, Rigshospitalet and Faculty of Health Sciences, University of Copenhagen, Denmark
    Exerc Immunol Rev 12:6-33. 2006
    ..Accordingly, a decreased plasma IL-6 concentration at rest as well as in response to exercise appears to characterize normal training adaptation...
  91. ncbi Costs and benefits of cold acclimation in field-released Drosophila
    Torsten N Kristensen
    Department of Genetics and Biotechnology, University of Aarhus, P O Box 50, DK 8830 Tjele, Denmark
    Proc Natl Acad Sci U S A 105:216-21. 2008
    ....
  92. ncbi Interactions between the direct and indirect effects of predators determine life history evolution in a killifish
    Matthew R Walsh
    Department of Biology, University of California, Riverside, CA 92521, USA
    Proc Natl Acad Sci U S A 105:594-9. 2008
    ..Rivulus from sites with predators better exploit the higher resources in those habitats. Therefore, both direct and indirect effects of predators have evolutionary consequences...
  93. ncbi Daily delivery of dietary nitrogen to the periphery is stable in rats adapted to increased protein intake
    C Morens
    Institut National de la Recherche Agronomique, , Institut National Agronomique de Paris-Grignon, F-75005 Paris, France
    Am J Physiol Endocrinol Metab 281:E826-36. 2001
    ..Digestive kinetics and splanchnic anabolism participate to a lesser extent in the regulation processes...
  94. ncbi Exercise reduces arterial pressure augmentation through vasodilation of muscular arteries in humans
    Shahzad Munir
    Dept of Clinical Pharmacology, St Thomas Hospital, Lambeth Palace Rd, London SE1 7EH, UK
    Am J Physiol Heart Circ Physiol 294:H1645-50. 2008
    ..2 +/- 0.4 to 8.6 +/- 0.4 mm, P < 0.05). In conclusion, exercise dilates muscular arteries and reduces arterial pressure augmentation, an effect that will enhance ventricular-vascular coupling and reduce load on the left ventricle...
  95. ncbi Postactivation potentiation influences differently the nonlinear summation of contractions in young and elderly adults
    Stéphane Baudry
    Laboratory of Applied Biology, Universite Libre de Bruxelles, 28 Ave P Héger, CP 168, 1000 Brussels, Belgium
    J Appl Physiol 98:1243-50. 2005
    ..This overall attenuation of potentiation with aging, however, appears to have a moderate influence on the decrement of the muscular performance...
  96. ncbi Acute effects of static stretching on passive stiffness of the hamstring muscles calculated using different mathematical models
    Antoine Nordez
    Laboratoire Motricit, Interactions, Performance, JE 2438, UFR STAPS, , France
    Clin Biomech (Bristol, Avon) 21:755-60. 2006
    ..INTERPRETATION: Stretching has significant effects on stiffness, but the findings highlight the need to carefully assess the effect of different models when analyzing such data...
  97. ncbi Modeling of muscle fatigue using Hill's model
    C Y Tang
    Department of Industrial and Systems Engineering, The Hong Kong Polytechnic University, Hung Hom, Kowloon, China
    Biomed Mater Eng 15:341-8. 2005
    ..The effects of different shapes of the recovery curves have also been considered in this model. Validation of the model has been performed by comparing the predicted results with the experimental data from an existing literature...
  98. ncbi The effect of AMPD1 genotype on blood flow response to sprint exercise
    Barbara Norman
    Department of Laboratory Medicine, Division of Clinical Physiology, Karolinska Institute, Karolinska University Hospital, Huddinge, 141 86 Stockholm, Sweden
    Eur J Appl Physiol 103:173-80. 2008
    ..8+/-1.1 min vs. 16.1+/-1.4 min, p<0.001). These results suggest a better circulatory adaptation to exercise in individuals with diminished mAMPD activity, probably due to an AMPD1 genotype-dependent increase in adenosine formation...
  99. ncbi 5'-AMP-activated protein kinase activity and protein expression are regulated by endurance training in human skeletal muscle
    Christian Frøsig
    Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, DK 2100 Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 286:E411-7. 2004
    ..Except for the increase in gamma1 protein, all observed adaptations to training could be ascribed to local contraction-induced mechanisms, since they did not occur in the contralateral untrained muscle...
  100. ncbi Leg stiffness modulation during exhaustive stretch-shortening cycle exercise
    S Kuitunen
    Department of Biology of Physical Activity, Neuromuscular Research Center, University of Jyvaskyla, Jyvaskyla, Finland
    Scand J Med Sci Sports 17:67-75. 2007
    ..It is suggested that efficient activity modulation (i.e. high EMG ratio) of the triceps surae muscle during an intensive fatiguing SSC exercise may postpone the exhaustion and development of metabolic fatigue...
  101. ncbi Voluntary activation and mechanical performance of human triceps surae muscle after exhaustive stretch-shortening cycle jumping exercise
    Sami Kuitunen
    Department of Biology of Physical Activity, University of Jyvaskyla, PO Box 35, FIN 40014 Jyvaskyla, Finland
    Eur J Appl Physiol 91:538-44. 2004
    ..The magnitude of post exercise contractile and activation failure as well as the delayed recovery of neuromuscular performance may have been augmented in some subjects due to their high number of jumps in the exercise...

Research Grants80

  1. NEUROIMMUNOMODULATION WITHIN THE EYE
    Andrew Taylor; Fiscal Year: 2006
    The eye normally possesses a unique physiological adaptation that regionally modifies the expression of immunity. This physiological adaptation is part of ocular immune privilege...
  2. Plasticity of nTS output neurons in acute and chronic hypoxia
    DAVID DOUGLAS KLINE; Fiscal Year: 2010
    ..This will be done in a model of OSA with the expectation of understanding potential therapeutic interventions. ..
  3. Prepregnancy Phenotype and Predisposition to Preeclampsia
    IRA MARK BERNSTEIN; Fiscal Year: 2010
    ..In addition, we are looking to understand the influence of pregnancy- specific, physiologic adaptations to the pathophysiologic associations of preeclampsia in a group of women at risk for developing preeclampsia. ..
  4. Spike After-Potentials of Oxytocin Cells in Lactation
    Ryoichi Teruyama; Fiscal Year: 2005
    My research interest has been focused on the physiological adaptation of animals to their different reproductive states...
  5. Mechanisms of Hemoglobin Adaptation to Hypoxia in High-altitude Rodents
    JAY STORZ; Fiscal Year: 2009
    The purpose of the proposed research project is to elucidate the molecular basis of physiological adaptation to high-altitude hypoxia, a condition resulting from a reduced supply of oxygen to the cells of respiring tissues...
  6. Mechanisms of Hemoglobin Adaptation to Hypoxia in High-altitude Rodents
    Jay F Storz; Fiscal Year: 2010
    The purpose of the proposed research project is to elucidate the molecular basis of physiological adaptation to high-altitude hypoxia, a condition resulting from a reduced supply of oxygen to the cells of respiring tissues...
  7. Mechanisms of Hemoglobin Adaptation to Hypoxia in High-altitude Rodents
    JAY STORZ; Fiscal Year: 2009
    The purpose of the proposed research project is to elucidate the molecular basis of physiological adaptation to high-altitude hypoxia, a condition resulting from a reduced supply of oxygen to the cells of respiring tissues...
  8. Mechanisms of Hemoglobin Adaptation to Hypoxia in High-altitude Rodents
    Jay F Storz; Fiscal Year: 2010
    The purpose of the proposed research project is to elucidate the molecular basis of physiological adaptation to high-altitude hypoxia, a condition resulting from a reduced supply of oxygen to the cells of respiring tissues...
  9. Role of phase-variable DNA methylase in virulence of Haemophilus influenzae
    Arnold Smith; Fiscal Year: 2007
    ..is common in clinical isolates and affects pathogenesis will provide the basis for future studies on the physiological adaptation of bacteria to different anatomic niches within the human host...
  10. Identification of Relaxin Receptor Antagonists
    Sheau Yu Hsu; Fiscal Year: 2005
    ..Thus, relaxin plays a significant role in the overall regulation of physiological adaptation during pregnancy...
  11. Imprint Osmoregulation/Maternally-Dehydrated Offspring
    Mina Desai; Fiscal Year: 2007
    ..We will determine the molecular and cellular mechanism(s) and peripheral renal AVP receptor changes. Finally, we will delineate the critical period during which imprinting of the AVP/osmoregulatory pathway occurs. ..
  12. Neuronal Responses to Effective Weight Loss Maintenance Strategies
    JASON R contact TREGELLAS; Fiscal Year: 2010
    ....
  13. PHYSIOLOGICAL ADAPTATION TO SUSTAINED HYPO-OSMOLALITY
    Joseph Verbalis; Fiscal Year: 2002
    ..These studies should lead to an elucidation of the cellular mechanisms underlying one of the most basic and intriguing unanswered question about clinically hyponatremic disorders. ..
  14. The Role of phosphoenolpyruvate carboxykinase and reactive oxygen species in the
    JASON EARL PODRABSKY; Fiscal Year: 2010
    ....
  15. NEUROENDOCRINE/IMMUNE INTERACTIONS: ROLE OF MELATONIN
    STEVEN YELLON; Fiscal Year: 2002
    ....
  16. NITRIC OXIDE SYNTHASE IN THE JUXTAGLOMERULAR APPARATUS
    CHRISTOPHER WILCOX; Fiscal Year: 2009
    ..abstract_text> ..
  17. PEROMYSCUS LABORATORY MODELS FOR BIOMEDICAL RESEARCH
    Michael Felder; Fiscal Year: 2009
    ..PGSC provides animals for a variety of fields, including human infectious disease, behavioral studies, physiological adaptation, and genetic studies...
  18. PEROMYSCUS LABORATORY MODELS FOR BIOMEDICAL RESEARCH
    Gabor Szalai; Fiscal Year: 2010
    ..PGSC provides animals for a variety of fields, including human infectious disease, behavioral studies, physiological adaptation, and genetic studies...
  19. Functional genomics of molluscan schistosome development
    TIMOTHY YOSHINO; Fiscal Year: 2009
    ..Results of this work may lead to novel strategies for controlling infections within the snail host by disrupting specific larval development-dependent genes or their products. ..
  20. CENTRAL CONTROL OF OXYTOCIN RELEASE DURING GESTATION
    STEVEN BEALER; Fiscal Year: 2007
    ..abstract_text> ..