physiological adaptation

Summary

Top Publications

  1. pmc Soft sweeps: molecular population genetics of adaptation from standing genetic variation
    Joachim Hermisson
    Section of Evolutionary Biology, Department of Biology II, Ludwig Maximilians University Munich, Germany
    Genetics 169:2335-52. 2005
  2. ncbi Molecular responses to dehydration and low temperature: differences and cross-talk between two stress signaling pathways
    K Shinozaki
    Laboratory of Plant Molecular Biology, Tsukuba Life Science Center, Institute of Physical and Chemical Research RIKEN, Tsukuba, 305 0074, Japan
    Curr Opin Plant Biol 3:217-23. 2000
  3. ncbi Evolution of high mutation rates in experimental populations of E. coli
    P D Sniegowski
    Department of Biology, University of Pennsylvania, Philadelphia 19104, USA
    Nature 387:703-5. 1997
  4. ncbi Adaptive radiation in a heterogeneous environment
    P B Rainey
    Department of Plant Sciences, University of Oxford, UK
    Nature 394:69-72. 1998
  5. ncbi The population genetics of ecological specialization in evolving Escherichia coli populations
    V S Cooper
    Center for Microbial Ecology, Michigan State University, East Lansing 48824, USA
    Nature 407:736-9. 2000
  6. ncbi OsDREB genes in rice, Oryza sativa L., encode transcription activators that function in drought-, high-salt- and cold-responsive gene expression
    Joseph G Dubouzet
    Biological Resources Division, Japan International Research Center for Agricultural Sciences JIRCAS, 1 1 Ohwashi, Tsukuba, Ibaraki 305 8686, Japan
    Plant J 33:751-63. 2003
  7. ncbi Sexually antagonistic male adaptation triggered by experimental arrest of female evolution
    W R Rice
    Department of Biology, University of California, Santa Cruz 95064, USA
    Nature 381:232-4. 1996
  8. ncbi Optimality and evolutionary tuning of the expression level of a protein
    Erez Dekel
    Department of Molecular Cell Biology and Department of Physics of Complex Systems, The Weizmann Institute of Science, Rehovot 76100, Israel
    Nature 436:588-92. 2005
  9. ncbi Selection on heritable phenotypic plasticity in a wild bird population
    Daniel H Nussey
    Netherlands Institute of Ecology NIOO KNAW, Post Office Box 40, 6666 ZG Heteren, Netherlands
    Science 310:304-6. 2005
  10. ncbi Experimental evolution of parasites
    D Ebert
    Universitat Basel, Zoologisches Institut, Rheinsprung 9, 4051 Basel, Switzerland
    Science 282:1432-5. 1998

Detail Information

Publications357 found, 100 shown here

  1. pmc Soft sweeps: molecular population genetics of adaptation from standing genetic variation
    Joachim Hermisson
    Section of Evolutionary Biology, Department of Biology II, Ludwig Maximilians University Munich, Germany
    Genetics 169:2335-52. 2005
    ..We find that soft sweeps with weaker selective footprints are likely under both scenarios if the mutation rate and/or the selection coefficient is high...
  2. ncbi Molecular responses to dehydration and low temperature: differences and cross-talk between two stress signaling pathways
    K Shinozaki
    Laboratory of Plant Molecular Biology, Tsukuba Life Science Center, Institute of Physical and Chemical Research RIKEN, Tsukuba, 305 0074, Japan
    Curr Opin Plant Biol 3:217-23. 2000
    ..Recent studies are providing evidence of differences between dehydration-signaling and cold-stress-signaling cascades, and of cross-talk between them...
  3. ncbi Evolution of high mutation rates in experimental populations of E. coli
    P D Sniegowski
    Department of Biology, University of Pennsylvania, Philadelphia 19104, USA
    Nature 387:703-5. 1997
    ..Our results corroborate computer simulations of mutator evolution in adapting clonal populations, and may help to explain observations that associate high mutation rates with emerging pathogens and with certain cancers...
  4. ncbi Adaptive radiation in a heterogeneous environment
    P B Rainey
    Department of Plant Sciences, University of Oxford, UK
    Nature 394:69-72. 1998
    ..These results demonstrate that the elementary processes of mutation and selection alone are sufficient to promote rapid proliferation of new designs and support the theory that trade-offs in competitive ability drive adaptive radiation...
  5. ncbi The population genetics of ecological specialization in evolving Escherichia coli populations
    V S Cooper
    Center for Microbial Ecology, Michigan State University, East Lansing 48824, USA
    Nature 407:736-9. 2000
    ..Thus, antagonistic pleiotropy appears more important than mutation accumulation for the decay of unused catabolic functions in these populations...
  6. ncbi OsDREB genes in rice, Oryza sativa L., encode transcription activators that function in drought-, high-salt- and cold-responsive gene expression
    Joseph G Dubouzet
    Biological Resources Division, Japan International Research Center for Agricultural Sciences JIRCAS, 1 1 Ohwashi, Tsukuba, Ibaraki 305 8686, Japan
    Plant J 33:751-63. 2003
    ..OsDREB1A is potentially useful for producing transgenic monocots that are tolerant to drought, high-salt, and/or cold stresses...
  7. ncbi Sexually antagonistic male adaptation triggered by experimental arrest of female evolution
    W R Rice
    Department of Biology, University of California, Santa Cruz 95064, USA
    Nature 381:232-4. 1996
    ..This male adaptation leads to a reduction in female survivorship, which is mediated by an increased rate of remating and increased toxicity of seminal fluid...
  8. ncbi Optimality and evolutionary tuning of the expression level of a protein
    Erez Dekel
    Department of Molecular Cell Biology and Department of Physics of Complex Systems, The Weizmann Institute of Science, Rehovot 76100, Israel
    Nature 436:588-92. 2005
    ..Thus, protein expression from the lac operon seems to be a solution of a cost-benefit optimization problem, and can be rapidly tuned by evolution to function optimally in new environments...
  9. ncbi Selection on heritable phenotypic plasticity in a wild bird population
    Daniel H Nussey
    Netherlands Institute of Ecology NIOO KNAW, Post Office Box 40, 6666 ZG Heteren, Netherlands
    Science 310:304-6. 2005
    ..This temporal trend is concurrent with climate change causing a mismatch between the breeding times of the birds and their caterpillar prey. Continued selection on plasticity can act to alleviate this mismatch...
  10. ncbi Experimental evolution of parasites
    D Ebert
    Universitat Basel, Zoologisches Institut, Rheinsprung 9, 4051 Basel, Switzerland
    Science 282:1432-5. 1998
    ..Understanding why parasite virulence seldom escalates similarly in natural populations could help us to manage virulence and deal with emerging diseases...
  11. pmc Interacting adaptive processes with different timescales underlie short-term motor learning
    Maurice A Smith
    Division of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA
    PLoS Biol 4:e179. 2006
    ..Our results suggest that motor adaptation depends on at least two distinct neural systems that have different sensitivity to error and retain information at different rates...
  12. ncbi Efficiency and ambiguity in an adaptive neural code
    A L Fairhall
    NEC Research Institute, 4 Independence Way, New Jersey 08540, USA
    Nature 412:787-92. 2001
    ..The speed with which information is optimized and ambiguities are resolved approaches the physical limit imposed by statistical sampling and noise...
  13. ncbi An implicit plan overrides an explicit strategy during visuomotor adaptation
    Pietro Mazzoni
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Neurosci 26:3642-5. 2006
    ..This suggests that the motor system requires that planned and executed trajectories remain congruous in visual space, and enforces this correspondence even at the expense of an opposing explicit task goal...
  14. pmc Sensory adaptation
    Barry Wark
    Graduate Program in Neurobiology and Behavior, University of Washington, United States
    Curr Opin Neurobiol 17:423-9. 2007
    ..Over longer timescales, adaptation is often power-law-like, implying the coexistence of multiple timescales in a single adaptive process. Models demonstrate that this can result from mechanisms within a single neuron...
  15. pmc The combined effect of drought stress and heat shock on gene expression in tobacco
    Ludmila Rizhsky
    Department of Biology, Technion Israel Institute of Technology, Technion City, Haifa 32000, Israel
    Plant Physiol 130:1143-51. 2002
    ..Therefore, improving stress tolerance of plants and crops may require a reevaluation, taking into account the effect of multiple stresses on plant metabolism and defense...
  16. ncbi Different trajectories of parallel evolution during viral adaptation
    H A Wichman
    Department of Biological Sciences, University of Idaho, Moscow, ID 83844, USA
    Science 285:422-4. 1999
    ..However, the order of these changes differed between replicates, and parallel substitutions did not reflect the changes with the largest beneficial effects or indicate a common trajectory of adaptation...
  17. ncbi Role of mutator alleles in adaptive evolution
    F Taddei
    Laboratoire de Mutagenese, Institut J Monod, CNRS Université Paris, France
    Nature 387:700-2. 1997
    ..The parameters of the model have been set to values typical for Escherichia coli cultures, which behave in a manner similar to the model in long-term adaptation experiments...
  18. pmc Transcriptome changes for Arabidopsis in response to salt, osmotic, and cold stress
    Joel A Kreps
    Torrey Mesa Research Institute, Syngenta, 3115 Merryfield Row, San Diego, California 92121, USA
    Plant Physiol 130:2129-41. 2002
    ..Although these results identify hundreds of potentially important transcriptome changes, the biochemical functions of many stress-regulated genes remain unknown...
  19. ncbi Physiological adaptation of the cardiovascular system to high altitude
    Robert Naeije
    Erasme University Hospital, Brussels, Belgium
    Prog Cardiovasc Dis 52:456-66. 2010
    ..Altitude exposure carries no identified risk of myocardial ischemia in healthy subjects but has to be considered as a potential stress in patients with previous cardiovascular conditions...
  20. ncbi Visual adaptation: physiology, mechanisms, and functional benefits
    Adam Kohn
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Neurophysiol 97:3155-64. 2007
    ..I conclude with a brief discussion of some important open questions in the field...
  21. ncbi Persistence of motor adaptation during constrained, multi-joint, arm movements
    R A Scheidt
    Department of Biomedical Engineering, Northwestern University, Evanston, IL 60622, USA
    J Neurophysiol 84:853-62. 2000
    ....
  22. ncbi Constraint to adaptive evolution in response to global warming
    J R Etterson
    University of Minnesota, Department of Ecology, Evolution and Behavior, Minnesota Center for Community Genetics, 1987 Upper Buford Circle, St Paul, MN 55108, USA
    Science 294:151-4. 2001
    ..Predicted rates of evolutionary response are much slower than the predicted rate of climate change...
  23. pmc Shifts in coding properties and maintenance of information transmission during adaptation in barrel cortex
    Miguel Maravall
    Instituto de Neurociencias de Alicante UMH CSIC, Campus de San Juan, Sant Joan d Alacant, Spain
    PLoS Biol 5:e19. 2007
    ..Our results suggest that adaptation enhances tactile representations in primary somatosensory cortex, where they could directly influence perceptual decisions...
  24. ncbi Adaptive norm-based coding of facial identity
    Gillian Rhodes
    School of Psychology, The University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia
    Vision Res 46:2977-87. 2006
    ..Component identities were also harder to detect in morphs of opposite than non-opposite face pairs. We propose an adaptive norm-based coding model of face identity...
  25. ncbi Quantifying generalization from trial-by-trial behavior of adaptive systems that learn with basis functions: theory and experiments in human motor control
    Opher Donchin
    Laboratory for Computational Motor Control, Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, Maryland 21205 2195, USA
    J Neurosci 23:9032-45. 2003
    ....
  26. pmc Precise adaptation in bacterial chemotaxis through "assistance neighborhoods"
    Robert G Endres
    Department of Molecular Biology, Princeton University, NJ 08544 1014, USA
    Proc Natl Acad Sci U S A 103:13040-4. 2006
    ..We predict two limits of precise adaptation at large attractant concentrations: Either receptors reach full methylation and turn off, or receptors become saturated and cease to respond to attractant but retain their adapted activity...
  27. pmc Mechanisms causing rapid and parallel losses of ribose catabolism in evolving populations of Escherichia coli B
    V S Cooper
    Center for Microbial Ecology, Michigan State University, East Lansing, Michigan 48824, USA
    J Bacteriol 183:2834-41. 2001
    ....
  28. ncbi Costs and benefits of high mutation rates: adaptive evolution of bacteria in the mouse gut
    A Giraud
    E9916, , , , 156 rue de Vaugirard, 75015 Paris, France
    Science 291:2606-8. 2001
    ..The short-term advantages and long-term disadvantages of mutator bacteria could account for their frequency in nature...
  29. ncbi Adaptation to gradual as compared with sudden visuo-motor distortions
    F A Kagerer
    Motor Control Laboratory, Arizona State University, Tempe 85287 0404, USA
    Exp Brain Res 115:557-61. 1997
    ..Results suggest that gradually increasing feedback distortion allows more complete adaptation than a large, sudden distortion onset...
  30. ncbi Pesticide resistance via transposition-mediated adaptive gene truncation in Drosophila
    Yael T Aminetzach
    Department of Biological Sciences, Stanford University, 371 Serra Mall, Stanford, CA 94305, USA
    Science 309:764-7. 2005
    ..The insertion of this transposable element confers increased resistance to an organophosphate pesticide and has spread in D. melanogaster recently...
  31. ncbi Incipient speciation by divergent adaptation and antagonistic epistasis in yeast
    Jeremy R Dettman
    Department of Ecology and Evolutionary Biology, University of Toronto, Mississauga, Ontario, L5L 1C6, Canada
    Nature 447:585-8. 2007
    ....
  32. pmc Impacts of climate warming on terrestrial ectotherms across latitude
    Curtis A Deutsch
    Program on Climate Change and Department of Oceanography and Department of Biology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 105:6668-72. 2008
    ..Our analyses imply that, in the absence of ameliorating factors such as migration and adaptation, the greatest extinction risks from global warming may be in the tropics, where biological diversity is also greatest...
  33. ncbi A 3'UTR pumilio-binding element directs translational activation in olfactory sensory neurons
    Julia A Kaye
    Cellular and Developmental Biology Program, 1 Shields Drive, University of California, Davis, Davis, CA 95616, USA
    Neuron 61:57-70. 2009
    ....
  34. pmc Dependence of bacterial chemotaxis on gradient shape and adaptation rate
    Nikita Vladimirov
    Interdisziplinares Zentrum fur Wissenschaftliches Rechnen, University of Heidelberg, Heidelberg, Germany
    PLoS Comput Biol 4:e1000242. 2008
    ..RapidCell is available from the authors upon request...
  35. ncbi Applications of prism adaptation: a tutorial in theory and method
    Gordon M Redding
    Department of Psychology, Illinois State University, Campus Box 4620, Normal, IL 61790 4620, USA
    Neurosci Biobehav Rev 29:431-44. 2005
    ....
  36. ncbi A universal model for spike-frequency adaptation
    Jan Benda
    Department of Physics, University of Ottawa, Ottawa, Ontario, K1N 6N5, Canada
    Neural Comput 15:2523-64. 2003
    ..As an extension of the model, we introduce a framework for combining an arbitrary spike generator with a generalized adaptation current...
  37. ncbi Parallel adaptations to high temperatures in the Archaean eon
    Bastien Boussau
    Laboratoire de Biometrie et Biologie Evolutive, CNRS, Universite de Lyon, Université Lyon I, 43 Boulevard du 11 Novembre, 69622 Villeurbanne, France
    Nature 456:942-5. 2008
    ..This analysis unifies apparently contradictory results into a coherent depiction of the evolution of an ecological trait over the entire tree of life...
  38. ncbi Population genomics of marine fishes: identifying adaptive variation in space and time
    Einar E Nielsen
    Technical University of Denmark, National Institute of Aquatic Resources, Vejlsøvej 39, Silkeborg, Denmark
    Mol Ecol 18:3128-50. 2009
    ....
  39. ncbi Components of sensorimotor adaptation in young and elderly subjects
    Otmar Bock
    Institute for Physiology and Anatomy, German Sport University, 50927, Koln, Germany
    Exp Brain Res 160:259-63. 2005
    ..This conclusion is supported by two additional findings: compared with young subjects our seniors performed less well on a cognitive screening test and acquired no explicit knowledge about the nature of the imposed visual distortion...
  40. pmc Reviewing molecular adaptations of Lyme borreliosis spirochetes in the context of reproductive fitness in natural transmission cycles
    Jean I Tsao
    Department of Fisheries and Wildlife, Michigan State University, East Lansing, MI 48864, USA
    Vet Res 40:36. 2009
    ..This holistic system approach may help researchers develop additional testable hypotheses about transmission processes, interpret laboratory results, and guide development of future LB control measures and management...
  41. pmc Arabidopsis UVR8 regulates ultraviolet-B signal transduction and tolerance and contains sequence similarity to human regulator of chromatin condensation 1
    Daniel J Kliebenstein
    The Boyce Thompson Institute for Plant Research and Section of Genetics and Development, Cornell University, Ithaca, New York 14853, USA
    Plant Physiol 130:234-43. 2002
    ..These results suggest that UVR8 acts in a UV-B signal transduction pathway leading to induction of flavonoid biosynthesis...
  42. ncbi Cerebellar LTD facilitates but is not essential for long-term adaptation of the vestibulo-ocular reflex
    A M Van Alphen
    Department of Neuroscience, Erasmus University Rotterdam, Dr Molenwaterplein 50, 3000 DR Rotterdam, The Netherlands
    Eur J Neurosci 16:486-90. 2002
    ..Thus, while LTD may be necessary for short-term VOR adaptation, it facilitates but is not required for long-term adaptation of the VOR...
  43. ncbi Rapid regulation of light harvesting and plant fitness in the field
    Carsten Külheim
    Umea Plant Science Center, Department of Plant Physiology, Umea University, SE 901 87 Umea, Sweden
    Science 297:91-3. 2002
    ....
  44. ncbi Significance of the V-type ATPase for the adaptation to stressful growth conditions and its regulation on the molecular and biochemical level
    K J Dietz
    Department of Physiology and Biochemistry of Plants, Faculty of Biology, University of Bielefeld, D 33501 Bielefeld, Germany
    J Exp Bot 52:1969-80. 2001
    ..The mechanisms known to regulate the V-ATPase are summarized in this paper with an emphasis on their implications for growth and development under stress...
  45. ncbi Adaptive responses to oxidative damage in three mutants of Caenorhabditis elegans (age-1, mev-1 and daf-16) that affect life span
    Sumino Yanase
    Department of Molecular Life Science, Tokai University School of Medicine, Boseidai, Isehara, Kanagawa 259 1193, Japan
    Mech Ageing Dev 123:1579-87. 2002
    ..This suggests that SOD and catalase do not play a role in the adaptive response against oxidative stress under hyperoxia, at least under these experimental conditions...
  46. ncbi Long-term characterization of firing dynamics of spontaneous bursts in cultured neural networks
    Jaap van Pelt
    Graduate School Neurosciences Amsterdam, Netherlands Institute for Brain Research, Neurons and Networks Research Group, 1105 AZ Amsterdam, The Netherlands
    IEEE Trans Biomed Eng 51:2051-62. 2004
    ....
  47. ncbi Hybridization and adaptive mate choice in flycatchers
    T Veen
    Department of Animal Ecology, Evolutionary Biology Centre, Uppsala University, SE-752 36 Uppsala, Sweden
    Nature 411:45-50. 2001
    ..Apparent hybridization may thus represent adaptive mate choice under some circumstances...
  48. ncbi HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
    Ioanna Papandreou
    Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305, USA
    Cell Metab 3:187-97. 2006
    ....
  49. ncbi Chemotaxis: how bacteria use memory
    Nikita Vladimirov
    Interdisziplinäres Zentrum für Wissenschaftliches Rechnen der Universität Heidelberg IWR, Im Neuenheimer Feld 368, D 69120 Heidelberg, Germany
    Biol Chem 390:1097-104. 2009
    ..Moreover, noise in the adaptation system, which results from variations of the adaptation rate both over time and among cells, might be beneficial for the overall chemotactic performance of the population...
  50. pmc Rapid, local adaptation of zooplankton behavior to changes in predation pressure in the absence of neutral genetic changes
    C Cousyn
    Laboratory of Aquatic Ecology, Katholieke Universiteit Leuven, Ch. De Beriotstraat 32, B-3000 Leuven, Belgium
    Proc Natl Acad Sci U S A 98:6256-60. 2001
    ....
  51. ncbi Evolution: the evolvability enigma
    J F Brookfield
    Institute of Genetics, University of Nottingham, Queens Medical Centre, NG7 2UH, Nottingham, UK
    Curr Biol 11:R106-8. 2001
    ..To what extent should processes of gene expression and control be interpreted in terms of their capacity to allow future evolution as well as present adaptation?..
  52. ncbi Visual cortex: Fatigue and adaptation
    M Carandini
    Swiss Federal Institute of Technology and University of Zurich, Switzerland
    Curr Biol 10:R605-7. 2000
    ..Recent results demonstrate that this visual adaptation is explained partly by a cellular mechanism acting in individual cortical neurons...
  53. pmc Erythropoietin regulates hypoxic ventilation in mice by interacting with brainstem and carotid bodies
    Jorge Soliz
    Institute of Veterinary Physiology, Vetsuisse Faculty, University of Zurich, Switzerland
    J Physiol 568:559-71. 2005
    ..These novel findings are relevant to understanding better respiratory disorders including those occurring at high altitude...
  54. ncbi Anabolism. Low mechanical signals strengthen long bones
    C Rubin
    Musculo Skeletal Research Laboratory, Department of Biomedical Engineering, State University of New York, Stony Brook, New York 11794 2580, USA
    Nature 412:603-4. 2001
    ..As the strain levels generated by this treatment are three orders of magnitude below those that damage bone tissue, this anabolic, non-invasive stimulus may have potential for treating skeletal conditions such as osteoporosis...
  55. ncbi Differential gene expression by Paracoccidioides brasiliensis in host interaction conditions: representational difference analysis identifies candidate genes associated with fungal pathogenesis
    Alexandre Melo Bailão
    Laboratorio de Biologia Molecular, Instituto de Ciencias Biologicas, Universidade Federal de Goias, 74001 970 Goiania, Goias, Brazil
    Microbes Infect 8:2686-97. 2006
    ..This work can facilitate functional studies of novel regulated genes that may be important for the survival and growth strategies of P. brasiliensis in humans...
  56. ncbi The evolutionary consequences of ecological interactions mediated through phenotypic plasticity
    James A Fordyce
    Department of Ecology and Evolutionary Biology, University of Tennessee, Knoxville, TN 37996, USA
    J Exp Biol 209:2377-83. 2006
    ....
  57. pmc Importance of hemodynamic forces as signals for exercise-induced changes in endothelial cell phenotype
    M Harold Laughlin
    Department of Biomedical Sciences, College of Veterinary Medicine, 1600 E Rollins Rd, University of Missouri, Columbia, MO 65211, USA
    J Appl Physiol (1985) 104:588-600. 2008
    ..We conclude that available evidence suggests that exercise signals formation of beneficial endothelial cell phenotype at least in part through changes in SS and wall stretch in the arteries...
  58. ncbi Concurrent adaptations of left and right arms to opposite visual distortions
    Otmar Bock
    Institute of Physiology and Anatomy, German Sport University, 50927 Koln, Germany
    Exp Brain Res 162:513-9. 2005
    ..The reduced aftereffects observed under bimanual conditions can be attributed to the well-known phenomenon of bimanual coupling, which is unrelated to adaptation...
  59. ncbi Escherichia coli acid resistance: tales of an amateur acidophile
    John W Foster
    Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile, Alabama 36695, USA
    Nat Rev Microbiol 2:898-907. 2004
    ..Surprisingly, certain microorganisms that grow at neutral pH have elegantly regulated systems that enable survival during excursions into acidic environments. The best-characterized acid-resistance system is found in E. coli...
  60. ncbi Adaptive evolution of non-coding DNA in Drosophila
    Peter Andolfatto
    Section of Ecology, Behavior and Evolution, Division of Biological Sciences, University of California San Diego, La Jolla, California 92093, USA
    Nature 437:1149-52. 2005
    ..These results imply that, although positive selection is clearly an important facet of protein evolution, adaptive changes to non-coding DNA might have been considerably more common in the evolution of D. melanogaster...
  61. ncbi Maternal effects provide phenotypic adaptation to local environmental conditions
    Laura F Galloway
    Department of Biology, University of Virginia, Charlottesville, VA 22904 4328, USA
    New Phytol 166:93-9. 2005
    ..Evaluating maternal environmental effects in an ecological context demonstrates that they may provide phenotypic adaptation to local environmental conditions...
  62. ncbi Evidence of HIV-1 adaptation to HLA-restricted immune responses at a population level
    Corey B Moore
    Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Level 2 North Block, Royal Perth Hospital, Wellington Street, WA 6000, Australia
    Science 296:1439-43. 2002
    ..At a population level, the degree of HLA-associated selection in viral sequence was predictive of viral load. These results support a fundamental role for HLA-restricted immune responses in driving and shaping HIV-1 evolution in vivo...
  63. pmc Time course of change in vasodilator function and capacity in response to exercise training in humans
    Toni M Tinken
    Research Institute for Sport and Exercise Science, Liverpool John Moores University, Liverpool, UK
    J Physiol 586:5003-12. 2008
    ....
  64. ncbi Kin selection and parasite evolution: higher and lower virulence with hard and soft selection
    L Chao
    Department of Biology, University of California San Diego 92093, USA
    Q Rev Biol 75:261-75. 2000
    ..We recognize that hard selection for virulence is more difficult to document, but we take our results to suggest that a kin selection model with soft selection may have general applicability...
  65. ncbi The art of the probable: system control in the adaptive immune system
    R N Germain
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1892, USA
    Science 293:240-5. 2001
    ....
  66. pmc Arabidopsis AtMYC2 (bHLH) and AtMYB2 (MYB) function as transcriptional activators in abscisic acid signaling
    Hiroshi Abe
    Biological Resources Division, Japan International Research Center for Agricultural Sciences, 1 1 Ohwashi, Tsukuba, Ibaraki 305 8686, Japan
    Plant Cell 15:63-78. 2003
    ..These results indicate that both AtMYC2 and AtMYB2 proteins function as transcriptional activators in ABA-inducible gene expression under drought stress in plants...
  67. ncbi Introduced species and their missing parasites
    Mark E Torchin
    Marine Science Institute and Department of Ecology, Evolution and Marine Biology, University of California, Santa Barbara, California 93106, USA
    Nature 421:628-30. 2003
    ....
  68. pmc Cerebellar contributions to adaptive control of saccades in humans
    Minnan Xu-Wilson
    Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 29:12930-9. 2009
    ....
  69. ncbi Audiovisual temporal adaptation of speech: temporal order versus simultaneity judgments
    Argiro Vatakis
    Crossmodal Research Laboratory, Department of Experimental Psychology, University of Oxford, 9 South Parks Road, Oxford, OX1 3UD, UK
    Exp Brain Res 185:521-9. 2008
    ....
  70. ncbi Selective adaptation in networks of cortical neurons
    Danny Eytan
    Faculties of Medicine, Technion Israel Institute of Technology, Haifa 31096, Israel
    J Neurosci 23:9349-56. 2003
    ..The observation that selective adaptation arises naturally in a network of cortical neurons developing ex vivo indicates that this is an inherent feature of spontaneously organizing cortical networks...
  71. ncbi Sensorimotor adaptation in speech production
    J F Houde
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 279:1213-6. 1998
    ....
  72. pmc The evolution of a pleiotropic fitness tradeoff in Pseudomonas fluorescens
    R Craig MacLean
    Department of Biology, McGill University, 1205 Avenue Docteur Penfield, Montreal, QC, Canada H3A 1B1
    Proc Natl Acad Sci U S A 101:8072-7. 2004
    ..These results provide a possible explanation of conflicting accounts for the cost of specialization...
  73. ncbi Reduced climbing and increased slipping adaptation in cochlear hair cells of mice with Myo7a mutations
    C J Kros
    School of Biological Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK
    Nat Neurosci 5:41-7. 2002
    ..We conclude that myosin VIIA participates in anchoring and holding membrane-bound elements to the actin core of the stereocilium. Myosin VIIA is therefore required for the normal gating of transducer channels...
  74. ncbi Genes commonly regulated by water-deficit stress in Arabidopsis thaliana
    Elizabeth A Bray
    Department of Botany and Plant Sciences, University of California, Riverside, CA 92521, USA
    J Exp Bot 55:2331-41. 2004
    ..A more detailed analysis of genes involved in cell wall metabolism, indicated that there was a global decrease in expression of genes that promote cell expansion...
  75. pmc The Arabidopsis thaliana SOS2 gene encodes a protein kinase that is required for salt tolerance
    J Liu
    Department of Plant Sciences, University of Arizona, Tucson, AZ 85721, USA
    Proc Natl Acad Sci U S A 97:3730-4. 2000
    ..This mutation abolishes SOS2 autophosphorylation, indicating that SOS2 protein kinase activity is required for salt tolerance...
  76. ncbi Intrinsic mechanisms for adaptive gain rescaling in barrel cortex
    Marta Díaz-Quesada
    Instituto de Neurociencias de Alicante, Universidad Miguel Hernández de Elche Consejo Superior de Investigaciones Científicas, Campus de San Juan, 03550 Sant Joan d Alacant, Spain
    J Neurosci 28:696-710. 2008
    ..Our results suggest that widely expressed intrinsic mechanisms participate in barrel cortex adaptation but that their recruitment is highly stimulus specific...
  77. ncbi Hsp101 is necessary for heat tolerance but dispensable for development and germination in the absence of stress
    S W Hong
    Department of Biochemistry and Molecular Biophysics, University of Arizona, Tucson, AZ 85721, USA
    Plant J 27:25-35. 2001
    ..The hot1-2 mutant also expresses Hsp101 in seeds, but at a tenfold reduced level, resulting in reduced thermotolerance of germinating seeds and underscoring the importance of Hsp101 to seed stress tolerance...
  78. ncbi Evolution of thermal dependence of growth rate of Escherichia coli populations during 20,000 generations in a constant environment
    V S Cooper
    Center for Microbial Ecology, Michigan State University, East Lansing 48824, USA
    Evolution 55:889-96. 2001
    ..Antagonistic pleiotropy therefore is more likely to be responsible for the evolution of thermal specialization observed in maximum growth rate...
  79. ncbi Genome divergence in two Prochlorococcus ecotypes reflects oceanic niche differentiation
    Gabrielle Rocap
    School of Oceanography, University of Washington, Seattle, Washington 98195, USA
    Nature 424:1042-7. 2003
    ..Some of these genes have obvious roles in determining the relative fitness of the ecotypes in response to key environmental variables, and hence in regulating their distribution and abundance in the oceans...
  80. ncbi Salinity tolerance of Populus
    S Chen
    College of Biological Sciences and Technology, Beijing Forestry University, Beijing, China
    Plant Biol (Stuttg) 12:317-33. 2010
    ..In future attempts towards increased salt resistance, barriers between different poplar sections must be overcome and application of novel biotechnological tools, such as gene stacking, are recommended...
  81. ncbi Maintaining a healthy SPANC balance through regulatory and mutational adaptation
    Thomas Ferenci
    School of Molecular and Microbial Biosciences, The University of Sydney, NSW 2006, Australia
    Mol Microbiol 57:1-8. 2005
    ....
  82. ncbi Heat shock protein genes and their functional significance in fish
    N Basu
    Faculty of Agricultural Sciences and AquaNet, University of British Columbia, Vancouver, BC, Canada
    Gene 295:173-83. 2002
    ....
  83. ncbi Critical reduction in beta-cell mass results in two distinct outcomes over time. Adaptation with impaired glucose tolerance or decompensated diabetes
    D Ross Laybutt
    Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    J Biol Chem 278:2997-3005. 2003
    ..Thus, both the severity and duration of hyperglycemia appear to contribute to the deterioration of the beta-cell phenotype found in diabetes...
  84. pmc Temporal expression of seven clock genes in the suprachiasmatic nucleus and the pars tuberalis of the sheep: evidence for an internal coincidence timer
    Gerald Lincoln
    Medical Research Council, Human Reproductive Sciences Unit, University of Edinburgh, Chancellor s Building, 49 Little France Crescent, Edinburgh EH16 4SB, Scotland, UK
    Proc Natl Acad Sci U S A 99:13890-5. 2002
    ....
  85. pmc Improving water use in crop production
    J I L Morison
    Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, UK
    Philos Trans R Soc Lond B Biol Sci 363:639-58. 2008
    ....
  86. ncbi Limited transfer of learning between unimanual and bimanual skills within the same limb
    Daichi Nozaki
    Centre for Neuroscience Studies, Department of Anatomy and Cell Biology, Queen s University, Kingston, Ontario K7L 3N6, Canada
    Nat Neurosci 9:1364-6. 2006
    ..These results suggest partial, but not complete, overlap in the learning processes involved in the acquisition of unimanual and bimanual skills...
  87. ncbi Cellular and developmental adaptations to hypoxia: a Drosophila perspective
    Nuria Magdalena Romero
    Instituto Leloir, Patricias Argentinas, Buenos Aires, Argentina
    Methods Enzymol 435:123-44. 2007
    ..Paradoxically, Sima is a negative regulator of growth. This suggests that Sima is engaged in a negative feedback loop that limits growth upon stimulation of InR/TOR pathways...
  88. pmc Evolutionary and functional insights into the mechanism underlying high-altitude adaptation of deer mouse hemoglobin
    Jay F Storz
    School of Biological Sciences, University of Nebraska, Lincoln, NE 68588, USA
    Proc Natl Acad Sci U S A 106:14450-5. 2009
    ..The experimental measures of O(2)-binding properties corroborated the tests of selection by demonstrating a functional difference between the products of alternative alleles...
  89. pmc Enhanced accumulation of BiP in transgenic plants confers tolerance to water stress
    F C Alvim
    Departamento de Biologia Vegetal, , , Minas Gerais, Brazil
    Plant Physiol 126:1042-54. 2001
    ..These results suggest that overexpression of BiP in plants may prevent endogenous oxidative stress...
  90. ncbi The genetics of adaptive shape shift in stickleback: pleiotropy and effect size
    Arianne Y K Albert
    Department of Zoology and Biodiversity Research Centre, University of British Columbia, Vancouver, BC, Canada
    Evolution 62:76-85. 2008
    ..Our results are consistent with predictions of the geometric model of adaptation. Shape evolution in stickleback results from a few genes with large and possibly widespread effects and multiple genes of smaller effect...
  91. pmc Role of guanylate cyclase-activating proteins (GCAPs) in setting the flash sensitivity of rod photoreceptors
    A Mendez
    The Mary D Allen Laboratory for Vision Research, Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles 90089 9112, USA
    Proc Natl Acad Sci U S A 98:9948-53. 2001
    ..We conclude that GCAPs strongly regulate GC activity in mouse rods, decreasing the flash sensitivity in darkness and increasing the incremental flash sensitivity in bright steady light, thereby extending the rod's operating range...
  92. ncbi Transgenerational plasticity is adaptive in the wild
    Laura F Galloway
    Department of Biology, University of Virginia, Charlottesville, VA 22904 4328, USA
    Science 318:1134-6. 2007
    ..4 times greater fitness than otherwise. Transgenerational plasticity has evolved in response to natural variation in light and provides a flexible mechanism by which sedentary organisms cope with heterogeneous environments...
  93. ncbi Remodeling of blood vessels: responses of diameter and wall thickness to hemodynamic and metabolic stimuli
    Axel R Pries
    Department of Physiology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Hypertension 46:725-31. 2005
    ....
  94. ncbi Response of plant metabolism to too little oxygen
    Peter Geigenberger
    Max Planck Institute of Molecular Plant Physiology, Am Muhlenberg 1, 14476 Golm, Germany
    Curr Opin Plant Biol 6:247-56. 2003
    ..Recently, advances have been made in elucidating possible oxygen-sensing systems and regulatory components that are involved in these responses...
  95. ncbi Bacterial biofilms: from the natural environment to infectious diseases
    Luanne Hall-Stoodley
    Department of Veterinary Molecular Microbiology, Departments of Microbiology and Civil Engineering, Center for Biofilm Engineering, Montana State University, Bozeman, Montana, USA
    Nat Rev Microbiol 2:95-108. 2004
    ..The implications of these survival and propagative mechanisms in the context of both the natural environment and infectious diseases are discussed in this review...
  96. ncbi Duration-dependent FMRI adaptation and distributed viewer-centered face representation in human visual cortex
    Fang Fang
    Department of Psychology, University of Minnesota, 75 East River Parkway, Minneapolis, MN 55455, USA
    Cereb Cortex 17:1402-11. 2007
    ..Our findings suggest that long- and short-term fMRI adaptations may reflect selective properties of different neuronal mechanisms...
  97. ncbi Prototype-referenced shape encoding revealed by high-level aftereffects
    D A Leopold
    , , Germany
    Nat Neurosci 4:89-94. 2001
    ..The results suggest that the encoding of faces and other complex patterns draws upon contrastive neural mechanisms that reference the central tendency of the stimulus category...
  98. ncbi Adaptation and the cost of complexity
    H A Orr
    Department of Biology, University of Rochester, New York 14627, USA
    Evolution 54:13-20. 2000
    ..The present results also suggest that one can define an effective number of dimensions characterizing an adapting species...
  99. pmc The small noncoding DsrA RNA is an acid resistance regulator in Escherichia coli
    Richard A Lease
    Wadsworth Center, New York State Department of Health, Center for Medical Sciences, Albany, New York, USA
    J Bacteriol 186:6179-85. 2004
    ..Whether DsrA targets acid resistance genes directly by base pairing or indirectly via perturbation of RpoS and/or H-NS is not known, but in either event, our results suggest that DsrA RNA may enhance the virulence of pathogenic E. coli...
  100. ncbi Transcriptional and physiological adaptation to defective protein-O-mannosylation in Candida albicans
    Pilar D Cantero
    Institut fur Mikrobiologie, Heinrich Heine Universitat Dusseldorf, Dusseldorf, Germany
    Mol Microbiol 64:1115-28. 2007
    ..While known signalling pathways modulate adaptation for a short-term, long-term adaptation requires calcineurin, adjustments of remaining Pmt activities and of glycolytic flow...
  101. ncbi Representation of perceived object shape by the human lateral occipital complex
    Z Kourtzi
    Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 293:1506-9. 2001
    ..These data indicate that the LOC represents not simple image features, but rather higher level shape information...

Research Grants62

  1. Effects of Evoked Resistance Training and Testosterone after Spinal Cord Injury
    Ashraf Gorgey; Fiscal Year: 2012
    ..The completion of the proposed experiment will allow the candidate to compete as an independent research investigator. ..
  2. Comparative Resistance Exercise Effects on Knee Osteoarthritis Pain, Functional I
    KEVIN ROBERT VINCENT; Fiscal Year: 2013
    ....
  3. Impact of AMP-activated kinase on sex differences in hypertrophic cardiomyopathy
    John P Konhilas; Fiscal Year: 2013
    ..Therefore, it is of major clinical significance that the mechanistic link be determined between cardiac disease, sex/gender differences and energetic regulators in the heart. ) ..
  4. Mechanisms of Haemophilus influenzae pathogenesis in the lung
    Hao Shen; Fiscal Year: 2013
    ..The proposed work will generate insight into the roles of bacterial genes of immune evasion and physiological adaptation required to survive anti-bacterial defenses modeled in vitro, and how these genes contribute to bacterial ..
  5. Plasticity of nTS output neurons in acute and chronic hypoxia
    DAVID DOUGLAS KLINE; Fiscal Year: 2013
    ..This will be done in a model of OSA with the expectation of understanding potential therapeutic interventions. ..
  6. Mechanisms of Haemophilus influenzae pathogenesis in the lung
    Hao Shen; Fiscal Year: 2011
    ..The proposed work will generate insight into the roles of bacterial genes of immune evasion and physiological adaptation required to survive anti-bacterial defenses modeled in vitro, and how these genes contribute to bacterial ..
  7. Alcohol, Glial Gene Expression and the Heat Shock Pathway
    Neil L Harrison; Fiscal Year: 2010
    ..Microglia are the immune component of the brain and eliminate foreign invaders. Alcohol may alter the activity of all three types of glial cell by changing gene expression, and in doing so may harm nerve cells. ..
  8. Negative regulation by thyroid hormone
    Anthony N Hollenberg; Fiscal Year: 2010
    ..Completion of these Aims will shed new light on how metabolic pathwys target gene expression to preserve metabolic homeostasis. This should allow for a better understanding of physiologic adaptation to disease. ..
  9. Physiological reactivity to acute stress during pregnancy
    LISA MICHELLE CHRISTIAN; Fiscal Year: 2010
    ..Moreover, limited information is available regarding effects of race on physiological adaptation to pregnancy...
  10. Weight Loss, Inflammation, and Vascular Endothelial Function in Older Adults
    Douglas R Seals; Fiscal Year: 2010
    ..The proposed study should provide the first insight into the role of reduced inflammation, oxidative stress and visceral adiposity in weight loss-mediated improvements in EDD in overweight/obese older adults. ..
  11. Mechanisms of Hemoglobin Adaptation to Hypoxia in High-altitude Rodents
    Jay F Storz; Fiscal Year: 2012
    The purpose of the proposed research project is to elucidate the molecular basis of physiological adaptation to high-altitude hypoxia, a condition resulting from a reduced supply of oxygen to the cells of respiring tissues...
  12. PEROMYSCUS LABORATORY MODELS FOR BIOMEDICAL RESEARCH
    Gabor Szalai; Fiscal Year: 2013
    ..PGSC provides animals for a variety of fields, including human infectious disease, behavioral studies, physiological adaptation, and genetic studies...
  13. p38 MAPK a regulator of muscle contraction and function
    Zhen Yan; Fiscal Year: 2013
    ..and PGC-11 MKO mice phenocopied p383 MKO, indicating the importance of the p383-PGC-11 axis in muscle physiological adaptation. In cultured myotubes, we and others have shown that atrophy induced by the oxidant hydrogen peroxide ..
  14. Antibiotic pressure and selection of TCA cycle mutants in Staphylococcus epidermi
    Paul D Fey; Fiscal Year: 2010
    ..6 log10 compared to wild type. Therefore, the loss of TCA cycle activity represents a physiological adaptation of the bacterium to an environment where antibiotic pressure is prevalent...
  15. Role of clock genes in colonic motility
    Chung Owyang; Fiscal Year: 2010
    ..Taken together, the data suggest that the colon may have a time-keeping capability that allows for the physiological adaptation of colonic motility to environmental stimuli...
  16. Neuronal Responses to Effective Weight Loss Maintenance Strategies
    Jason R Tregellas; Fiscal Year: 2013
    ..By understanding the complex interactions between the brain response to eating and food cues and physiologic changes with these interventions we hope to be able to develop new strategies and/or interventions for sustained weight loss. ..
  17. NsrR regulation of the small noncoding RNA RybB in Escherichia coli
    Karl M Thompson; Fiscal Year: 2013
    ..The models resulting from these studies will contribute to refined physiological models for systems biology applications. ..
  18. Prepregnancy Phenotype and Predisposition to Preeclampsia
    IRA MARK BERNSTEIN; Fiscal Year: 2013
    ..3. That normal pregnancy predisposes women to increases in posterior cerebral edema in the third trimester and that this edema is exacerbated in association with elevated systemic blood pressure in late pregnancy. ..
  19. Genomics of natural populations
    ALAN OLAV BERGLAND; Fiscal Year: 2013
    ....
  20. Interactions between neuronal networks that regulate food intake and body weight
    Lori M Zeltser; Fiscal Year: 2013
    ....
  21. Regulation of the Hypoxia Inducible Factor (HIF)
    Richard K Bruick; Fiscal Year: 2010
    ..This pathway contributes to both the physiological adaptation to hypoxic stress as well as the progression of a number of disease states in which oxygen supply is ..
  22. Brainstem Mechanisms of Stress Regulation
    James P Herman; Fiscal Year: 2013
    ..The current proposal uses rodent chronic stress models to address mechanisms that control physiological adaptation and dysfunction following long-term stress...
  23. Dose-Response Study of Exercise in Older Adults
    JEFFREY MURRAY BURNS; Fiscal Year: 2011
    ..The current study will provide important public health information regarding fundamental questions about exercise in delaying age-related cognitive and functional decline. ..
  24. The Role of phosphoenolpyruvate carboxykinase and reactive oxygen species in the
    JASON EARL PODRABSKY; Fiscal Year: 2013
    ....
  25. Muscle Plasticity, Fitness, and Health after Spinal Cord Injury
    Kevin K McCully; Fiscal Year: 2013
    ..Thus, this research has the potential to significantly benefit people with spinal cord injuries. ..
  26. Development of an Interactive Feedback System to Improve Neonatal Resuscitation
    TINA ANNE LEONE; Fiscal Year: 2013
    ..We believe that the use of such a system has the potential to significantly reduce neonatal morbidity and mortality in the most vulnerable and compromised infants. ..
  27. Top-Down Control of Serotonergic Circuits in Depressive-Like Behaviors
    COLLIN M CHALLIS; Fiscal Year: 2012
    ..Results from this work will contribute to the development of more effective and efficient antidepressant strategies. ..
  28. Corpus Luteal Contribution to Maternal Pregnancy Physiology and Outcomes in ART
    Kirk P Conrad; Fiscal Year: 2013
    ..There are numerous intellectual and logistical interactions and potent synergisms among the component Projects and Cores. ..
  29. Identifying Chemical Modulators of CRF-Binding Protein and CRF Receptor Complexes
    NICHOLAS DAVID COSFORD; Fiscal Year: 2013
    ....
  30. MECHANISMS OF EXERCISE INDUCED ASTHMA IN HUMANS
    Kenneth Beck; Fiscal Year: 2000
    ..In addition, results from these studies may suggest therapies to improve airway function, particularly as related to exercise, in asthmatics. ..
  31. MEMBRANE TRAFFICKING OF OPIOID RECEPTORS
    MARK E VONZASTROW; Fiscal Year: 2013
    ..understanding mechanisms by which G protein-coupled receptors are regulated and specific relevance to mechanisms underlying physiological adaptation of the nervous system in response to clinically important opiate drugs.
  32. ARACHIDONATE LIPOXYGENASE ACTIVITIES IN HUMAN PREGNANCY
    Murray Mitchell; Fiscal Year: 1992
    ..Hence, more effective approaches to the management of such pregnancies may be developed...
  33. Spike After-Potentials of Oxytocin Cells in Lactation
    Ryoichi Teruyama; Fiscal Year: 2005
    My research interest has been focused on the physiological adaptation of animals to their different reproductive states...
  34. Identification of Relaxin Receptor Antagonists
    Sheau Yu Hsu; Fiscal Year: 2005
    ..Thus, relaxin plays a significant role in the overall regulation of physiological adaptation during pregnancy...
  35. Imprint Osmoregulation/Maternally-Dehydrated Offspring
    Mina Desai; Fiscal Year: 2007
    ..We will determine the molecular and cellular mechanism(s) and peripheral renal AVP receptor changes. Finally, we will delineate the critical period during which imprinting of the AVP/osmoregulatory pathway occurs. ..
  36. NEUROIMMUNOMODULATION WITHIN THE EYE
    Andrew Taylor; Fiscal Year: 1999
    The eye possesses a unique physiological adaptation that modifies the induction and expression of immunity within its tissues. This physiological adaptation is known as immune privilege. Normally the eye is an immune privileged site...
  37. PHYSIOLOGICAL ADAPTATION TO SUSTAINED HYPO-OSMOLALITY
    Joseph Verbalis; Fiscal Year: 2002
    ..These studies should lead to an elucidation of the cellular mechanisms underlying one of the most basic and intriguing unanswered question about clinically hyponatremic disorders. ..
  38. Geographic models of selective sweeps
    PETER LOCHHEAD RALPH; Fiscal Year: 2012
    ..genomic loci responding to selection pressures, and so find loci involved in disease response and in physiological adaptation to local conditions...
  39. ATRIAL NATRIURETIC PEPTIDE IN RENAL GROWTH
    ROBERT CHEVALIER; Fiscal Year: 1990
    ....
  40. NEUROENDOCRINE/IMMUNE INTERACTIONS: ROLE OF MELATONIN
    STEVEN YELLON; Fiscal Year: 2002
    ....
  41. Functional genomics of molluscan schistosome development
    TIMOTHY YOSHINO; Fiscal Year: 2009
    ..Results of this work may lead to novel strategies for controlling infections within the snail host by disrupting specific larval development-dependent genes or their products. ..
  42. Outcomes of Delayed Cord Clamping in VLBW Infants
    Judith Mercer; Fiscal Year: 2005
    ..These studies will establish if there is enough evidence to support the practice of delayed cord clamping in preterm infants. This project will provide the foundation for further research in larger preterm and term infants. ..
  43. REGULATION OF LEFT VENTRICULAR FUNCTION IN HYPERTROPHY
    Song Jung Kim; Fiscal Year: 2003
    DESCRIPTION: (Verbatim from the application): Ventricular hypertrophy is a physiological adaptation by which the heart compensates for an increased workload, which may ultimately lead to decompensation and heart failure...
  44. ADAPTIVE MECHANISM TO LOW CALCIUM INTAKE DURING PUBERTY
    Steven Abrams; Fiscal Year: 2000
    ..Virtually no information is available regarding the physiological adaptation to these low intakes...
  45. Bordetella Response to Host Cues and Cell Signals
    David Relman; Fiscal Year: 2004
    ..pertussis virulence mechanisms and physiological adaptations, as well as the complex interplay between this pathogen and the human host, which could, in turn, lead to the development of novel pertussis vaccines and therapeutics. ..
  46. Decay of Acclimation and Time for Re-acclimation
    CANDI ASHLEY; Fiscal Year: 2004
    ..These goals can be accomplished with an experimental design that systematically determines loss of acclimation and time to re-establish acclimation. ..
  47. ENVIRONMENTAL INFLUENCES ON SYNAPTIC PHARMACOLOGY
    RICHARD ZIGMOND; Fiscal Year: 1993
    ....
  48. Global regulatory interactions in bacterial pathogenesis
    BRIAN AKERLEY; Fiscal Year: 2006
    ..influenzae in the context of epithelial cell interactions and in a model of respiratory tract infection. 3. Examine coordinate regulation of virulence factors by redox signaling systems. ..
  49. INTEGRATION OF STRESS RESPONSE IN ONTOGENY--ROLE OF CRF
    Cynthia Kuhn; Fiscal Year: 1991
    ..Furthermore, by understanding the ontogeny of different components of the stress response and its neural mediators, the impact of early stress on subsequent neuroendocrine reactivity and behavioral development can be better understood...
  50. The Biology of Resilience: Oxytocin, Social Relationships and Health
    Laura D Kubzansky; Fiscal Year: 2010
    ..Ultimately, a neurobiological understanding of resilience may inform efforts for both prevention and intervention of diseases or problems common in later life. ..
  51. 3D Shape Correspondence Quantification of Surgical Outcomes
    Lucia Cevidanes; Fiscal Year: 2009
    ..This work will provide preliminary data for future research applications on 3D computer simulation for diagnosis and surgical treatment planning, and for outcome assessments of new treatment procedures. ..
  52. Muscle-Powered VAD Chronic Studies in Conscious Animal
    David Dean; Fiscal Year: 2007
    ..The applicants further expect that practical application of this technology will have been demonstrated via implant testing of a complete muscle-actuated ventricular assist system. [unreadable] [unreadable]..
  53. EXERCISE CONDITIONING IN OLDER CORONARY PATIENTS
    Philip Ades; Fiscal Year: 1992
    ..Entry level data (clinical, demographic, psychosocial) will be analyzed to determine predictors of participation and nonparticipation in an exercise- based rehabilitation program for older coronary patients...
  54. FETAL ACTIVITY AND HYPOXIA DURING DEVELOPMENT
    Raymond Stark; Fiscal Year: 1999
    ..in the supply of oxygen and nutrients, new understanding of the continuum from normal responsiveness and physiological adaptation to pathological decompensation will be obtained...
  55. BIO-TELEMETRY IN THE STUDY OF VENTILATORY CONTROL
    MYRON EVANICH; Fiscal Year: 1980
    ..Data will be obtained during acute hypercapnia and hypoxia in combination with acute and chronic airway obstruction...
  56. Fetal Adaptation of Chronic Uterine Blood Flow Reduction
    David Boyle; Fiscal Year: 2006
    ..The overall hypothesis is that fetal growth restriction due to chronic UtBF reduction is a physiological adaptation to an inadequate supply of oxygen and nutrients to the fetus and placenta...
  57. Physiological Adaptations to Exercise in Burned Children
    Oscar Suman; Fiscal Year: 2006
    ..We expect these Specific Aims to serve as a springboard for future studies in the treatment and long-term rehabilitation of burned children. ..
  58. 2009 GRC Muscle: Excitation/Contraction Coupling
    KURT BEAM; Fiscal Year: 2009
    ..to, or result from, muscle diseases and fatigue, and the role of calcium signals in the development, physiological adaptation and aging of muscle...
  59. RESEARCH TRAINING IN PHYSIOLOGICAL ADAPTATION TO STRESS
    Leonard Jefferson; Fiscal Year: 2005
    ..abstract_text> ..
  60. Spatiotemporal Dynamics of Emotional Memory Networks
    KEVIN LABAR; Fiscal Year: 2005
    ..The proposed studies may lead to new insights into understanding these effects by providing a more accurate and detailed account of the dynamic interplay between emotion and memory systems in the human brain. ..
  61. PHYSIOLOGICAL ADAPTATION AND MUSCLE PROTEIN TRANSITIONS
    Frederick Schachat; Fiscal Year: 1993
    ....
  62. Post-endocytic Sorting of Opioid Receptors
    Mark von Zastrow; Fiscal Year: 2009
    ..mechanisms by which G protein-coupled receptors are regulated, and will contribute fundamental information to understanding physiological adaptation of the nervous system in response to clinically important opiate drugs.