larva

Summary

Summary: Wormlike or grublike stage, following the egg in the life cycle of insects, worms, and other metamorphosing animals.

Top Publications

  1. pmc Anopheles gambiae: historical population decline associated with regional distribution of insecticide-treated bed nets in western Nyanza Province, Kenya
    M Nabie Bayoh
    Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, 48824, USA
    Malar J 9:62. 2010
  2. pmc Field-evolved resistance to Bt maize by western corn rootworm
    Aaron J Gassmann
    Department of Entomology, Iowa State University, Ames, Iowa, United States of America
    PLoS ONE 6:e22629. 2011
  3. pmc A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish
    Philipp Niethammer
    Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 459:996-9. 2009
  4. ncbi Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes
    Eric J Rulifson
    Department of Developmental Biology, Beckman Center B300, Stanford University, Stanford, CA 94305 5329, USA
    Science 296:1118-20. 2002
  5. ncbi Flies without centrioles
    Renata Basto
    The Gurdon Institute, Tennis Court Road, Cambridge CB2 1QN, UK
    Cell 125:1375-86. 2006
  6. pmc Integrated malaria vector control with microbial larvicides and insecticide-treated nets in western Kenya: a controlled trial
    Ulrike Fillinger
    Disease Control and Vector Biology Unit, London School of Hygiene and Tropical Medicine, London, England
    Bull World Health Organ 87:655-65. 2009
  7. pmc Fat cells reactivate quiescent neuroblasts via TOR and glial insulin relays in Drosophila
    Rita Sousa-Nunes
    Division of Developmental Neurobiology, Medical Research Council National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Nature 471:508-12. 2011
  8. pmc Larval habitat segregation between the molecular forms of the mosquito Anopheles gambiae in a rice field area of Burkina Faso, West Africa
    G Gimonneau
    Maladies Infectieuses et Vecteurs Ecologie, Genetique, Evolution et Contrôle, UMR224, Institut de Recherche pour le Developpement, 911 Avenue Agropolis, Montpellier, France
    Med Vet Entomol 26:9-17. 2012
  9. pmc Toward an understanding of the molecular mechanisms of barnacle larval settlement: a comparative transcriptomic approach
    Zhang Fan Chen
    KAUST Global Collaborative Research Program, Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong SAR, China
    PLoS ONE 6:e22913. 2011
  10. ncbi Modulation of locomotor activity in larval zebrafish during light adaptation
    Harold A Burgess
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6058, USA
    J Exp Biol 210:2526-39. 2007

Detail Information

Publications274 found, 100 shown here

  1. pmc Anopheles gambiae: historical population decline associated with regional distribution of insecticide-treated bed nets in western Nyanza Province, Kenya
    M Nabie Bayoh
    Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, 48824, USA
    Malar J 9:62. 2010
    ..l.) species complex, namely A. gambiae sensu stricto (s.s.) and Anopheles arabiensis. Historically, the former species was proportionately dominant in indoor resting collections of females...
  2. pmc Field-evolved resistance to Bt maize by western corn rootworm
    Aaron J Gassmann
    Department of Entomology, Iowa State University, Ames, Iowa, United States of America
    PLoS ONE 6:e22629. 2011
    ..However, the evolution of resistance could cut short these benefits. A primary pest targeted by Bt maize in the United States is the western corn rootworm Diabrotica virgifera virgifera (Coleoptera: Chrysomelidae)...
  3. pmc A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish
    Philipp Niethammer
    Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 459:996-9. 2009
    ..This is the first observation, to our knowledge, of a tissue-scale H(2)O(2) pattern, and the first evidence that H(2)O(2) signals to leukocytes in tissues, in addition to its known antiseptic role...
  4. ncbi Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes
    Eric J Rulifson
    Department of Developmental Biology, Beckman Center B300, Stanford University, Stanford, CA 94305 5329, USA
    Science 296:1118-20. 2002
    ..Interestingly, the phenotype of flies lacking IPCs includes certain features of diabetes mellitus...
  5. ncbi Flies without centrioles
    Renata Basto
    The Gurdon Institute, Tennis Court Road, Cambridge CB2 1QN, UK
    Cell 125:1375-86. 2006
    ..Thus, centrioles are essential for the formation of centrosomes, cilia, and flagella, but, remarkably, they are not essential for most aspects of Drosophila development...
  6. pmc Integrated malaria vector control with microbial larvicides and insecticide-treated nets in western Kenya: a controlled trial
    Ulrike Fillinger
    Disease Control and Vector Biology Unit, London School of Hygiene and Tropical Medicine, London, England
    Bull World Health Organ 87:655-65. 2009
    ....
  7. pmc Fat cells reactivate quiescent neuroblasts via TOR and glial insulin relays in Drosophila
    Rita Sousa-Nunes
    Division of Developmental Neurobiology, Medical Research Council National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Nature 471:508-12. 2011
    ..This mechanism indicates that dietary nutrients and remote organs, as well as local niches, are key regulators of transitions in stem-cell behaviour...
  8. pmc Larval habitat segregation between the molecular forms of the mosquito Anopheles gambiae in a rice field area of Burkina Faso, West Africa
    G Gimonneau
    Maladies Infectieuses et Vecteurs Ecologie, Genetique, Evolution et Contrôle, UMR224, Institut de Recherche pour le Developpement, 911 Avenue Agropolis, Montpellier, France
    Med Vet Entomol 26:9-17. 2012
    ..Segregation appears to be clearly linked to anthropogenic permanent habitats and the community structure they support...
  9. pmc Toward an understanding of the molecular mechanisms of barnacle larval settlement: a comparative transcriptomic approach
    Zhang Fan Chen
    KAUST Global Collaborative Research Program, Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong SAR, China
    PLoS ONE 6:e22913. 2011
    ..The pyrosequencing-based transcriptomic approach is thought to be useful to identify key molecular changes during larval settlement...
  10. ncbi Modulation of locomotor activity in larval zebrafish during light adaptation
    Harold A Burgess
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6058, USA
    J Exp Biol 210:2526-39. 2007
    ..We propose that regulation of motor activity by photic stimuli in zebrafish larvae serves a behavioral goal of maximizing exposure to well lit environments optimal for feeding...
  11. doi Field-evolved resistance to Bt toxin Cry1Ac in the pink bollworm, Pectinophora gossypiella (Saunders) (Lepidoptera: Gelechiidae), from India
    Sanyasi Dhurua
    Division of Entomology, Indian Agricultural Research Institute, New Delhi, India
    Pest Manag Sci 67:898-903. 2011
    ..During the 2007-2008 and 2008-2009 seasons, pink bollworm populations in India were surveyed to evaluate their responses to Cry1Ac and seed powder containing Cry1Ac and Cry2Ab2...
  12. pmc Microbial colonization induces dynamic temporal and spatial patterns of NF-κB activation in the zebrafish digestive tract
    Michelle Kanther
    Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, North Carolina, USA
    Gastroenterology 141:197-207. 2011
    ..We used in vivo imaging and molecular approaches to analyze NF-κB activation in response to the commensal microbiota in transparent gnotobiotic zebrafish...
  13. ncbi Connectivity of marine populations: open or closed?
    R K Cowen
    Rosenstiel School of Marine and Atmospheric Science, University of Miami, Miami, FL 33149, USA
    Science 287:857-9. 2000
    ..The alternative process of larval retention near local populations is shown to exist and may be of great importance in the maintenance of marine population structure and management of coastal marine resources...
  14. ncbi daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans
    K D Kimura
    Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Science 277:942-6. 1997
    ..Life-span regulation by insulin-like metabolic control is analogous to mammalian longevity enhancement induced by caloric restriction, suggesting a general link between metabolism, diapause, and longevity...
  15. ncbi Field-evolved insect resistance to Bt crops: definition, theory, and data
    Bruce E Tabashnik
    Department of Entomology, University of Arizona, Tucson, AZ 85721, USA
    J Econ Entomol 102:2011-25. 2009
    ....
  16. ncbi Scaling of connectivity in marine populations
    R K Cowen
    Marine Biology and Fisheries, Rosenstiel School of Marine and Atmospheric Science, University of Miami, 4600 Rickenbacker Causeway, Miami, FL 33149, USA
    Science 311:522-7. 2006
    ..The results reveal distinct regions of population isolation based on larval dispersal that also correspond to genetic and morphological clines observed across a range of marine organisms...
  17. ncbi painless, a Drosophila gene essential for nociception
    W Daniel Tracey
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Cell 113:261-73. 2003
    ..An antibody to Painless binds to localized dendritic structures that we hypothesize are involved in nociceptive signaling...
  18. doi Remote control of insulin secretion by fat cells in Drosophila
    Charles Geminard
    Institute for Developmental Biology and Cancer, CNRS University of Nice Sophia Antipolis, Parc Valrose, 06108 Nice, France
    Cell Metab 10:199-207. 2009
    ..Thus, the availability of nutrients is remotely sensed in fat body cells and conveyed to the brain IPCs by a humoral signal controlling ILP release...
  19. ncbi Coral reef fish larvae settle close to home
    Geoffrey P Jones
    Centre for Coral Reef Biodiversity, School of Marine Biology and Aquaculture, James Cook University, Townsville, Qld 4811, Australia
    Curr Biol 15:1314-8. 2005
    ..The degree of local retention indicates that marine reserves can provide recruitment benefits not only beyond but also within their boundaries...
  20. pmc Diabetic larvae and obese flies-emerging studies of metabolism in Drosophila
    Keith D Baker
    Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112 5331, USA
    Cell Metab 6:257-66. 2007
    ....
  21. ncbi Functional imaging reveals rapid development of visual response properties in the zebrafish tectum
    Cristopher M Niell
    Neutosciences Program, Department of Molecular and Cell Physiology, Stanford University, Stanford, California 94305, USA
    Neuron 45:941-51. 2005
    ..Surprisingly, most of these properties are established soon after dendrite growth and synaptogenesis begin and do not require patterned visual experience or a protracted period of refinement...
  22. ncbi Local replenishment of coral reef fish populations in a marine reserve
    Glenn R Almany
    Australian Research Council Centre of Excellence for Coral Reef Studies and School of Marine and Tropical Biology, James Cook University, Townsville QLD 4811, Australia
    Science 316:742-4. 2007
    ..If natal homing of larvae is a common life-history strategy, the appropriate spatial scales for the management and conservation of coral reefs are likely to be much smaller than previously assumed...
  23. pmc Pickpocket is a DEG/ENaC protein required for mechanical nociception in Drosophila larvae
    Lixian Zhong
    Pharmacology Science Training Program, Duke University Medical Center, Durham, NC 27710, USA
    Curr Biol 20:429-34. 2010
    Highly branched class IV multidendritic sensory neurons of the Drosophila larva function as polymodal nociceptors that are necessary for behavioral responses to noxious heat (>39 degrees C) or noxious mechanical (>30 mN) stimuli...
  24. doi Royalactin induces queen differentiation in honeybees
    Masaki Kamakura
    Biotechnology Research Center, Toyama Prefectural University, Imizu, Toyama 939 0398, Japan
    Nature 473:478-83. 2011
    ..These findings indicate that a specific factor in royal jelly, royalactin, drives queen development through an Egfr-mediated signalling pathway...
  25. pmc Defining challenges and proposing solutions for control of the virus vector Aedes aegypti
    Amy C Morrison
    Department of Entomology, University of California, Davis, Davis, California, United States of America
    PLoS Med 5:e68. 2008
  26. pmc Differential alteration of two aminopeptidases N associated with resistance to Bacillus thuringiensis toxin Cry1Ac in cabbage looper
    Kasorn Tiewsiri
    Department of Entomology, Cornell University, New York State Agricultural Experiment Station, Geneva, NY 14456, USA
    Proc Natl Acad Sci U S A 108:14037-42. 2011
    ..Along with identifying reduced expression of APN1 as the molecular basis of Bt resistance selected in an agricultural setting, our findings demonstrate the importance of APN1 to the mode of action of Bt toxin Cry1Ac...
  27. ncbi Anopheles gambiae s.s. breeding in polluted water bodies in urban Lagos, southwestern Nigeria
    T S Awolola
    Public Health Division, Nigerian Institute of Medical Research, Yaba, Lagos, Nigeria
    J Vector Borne Dis 44:241-4. 2007
    ..Urban malaria is on the rise in Nigeria due to rapid industrialisation and developmental activities. A study was undertaken in Lagos, Nigeria to study the Anopheles breeding in polluted water bodies...
  28. doi Maize landraces recruit egg and larval parasitoids in response to egg deposition by a herbivore
    Amanuel Tamiru
    Habitat Management Programme, International Centre of Insect Physiology and Ecology, PO Box 30, Mbita Point, Kenya
    Ecol Lett 14:1075-83. 2011
    ..Our findings suggest that indirect plant defence traits may have become lost during crop breeding and could be valuable in new resistance breeding for sustainable agriculture...
  29. doi Cross-induction of detoxification genes by environmental xenobiotics and insecticides in the mosquito Aedes aegypti: impact on larval tolerance to chemical insecticides
    Rodolphe Poupardin
    Laboratoire d Ecologie Alpine, UMR CNRS Université Joseph Fourier 5553, Equipe Perturbations Environnementales et Xénobiotiques, Domaine Universitaire de Saint Martin d Hères 2233, rue de la piscine Bât D Biologie, BP 53, 38041 Grenoble Cedex 9, France
    Insect Biochem Mol Biol 38:540-51. 2008
    ..Molecular mechanisms involved and impact on mosquito control strategies are discussed...
  30. pmc Unexpected high losses of Anopheles gambiae larvae due to rainfall
    Krijn P Paaijmans
    Meteorology and Air Quality, Wageningen University, Wageningen, The Netherlands
    PLoS ONE 2:e1146. 2007
    ..Here we study the impact of rainfall, one of the abiotic factors to which the immatures are frequently exposed, on their mortality...
  31. ncbi Characteristics of larval anopheline (Diptera: Culicidae) habitats in Western Kenya
    J E Gimnig
    Kenya Medical Research Institute, Centre for Vector Biology and Control Research, Kisumu
    J Med Entomol 38:282-8. 2001
    ..Together, these results indicate that An. gambiae and An. arabiensis have similar requirements for the larval environment and that, at least in western Kenya, they do not segregate into separate habitats...
  32. doi Lactobacillus plantarum promotes Drosophila systemic growth by modulating hormonal signals through TOR-dependent nutrient sensing
    Gilles Storelli
    Institut de Biologie du Developpement de Marseille Luminy, CNRS UMR 6216 Aix Marseille Universités, 13288 Marseille, France
    Cell Metab 14:403-14. 2011
    ..Our results indicate that the intestinal microbiota should also be envisaged as a factor that influences the systemic growth of its host...
  33. pmc Development of vegetable farming: a cause of the emergence of insecticide resistance in populations of Anopheles gambiae in urban areas of Benin
    Anges William M Yadouleton
    Centre de Recherche Entomologique de Cotonou, Benin
    Malar J 8:103. 2009
    ..This study aims to assess the rapid expansion of urban agriculture especially, its contribution to the emergence of insecticide resistance in populations of Anopheles gambiae...
  34. ncbi Spatiotemporal gene expression targeting with the TARGET and gene-switch systems in Drosophila
    Sean E McGuire
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Sci STKE 2004:pl6. 2004
    ..In this protocol, we provide guidelines for the use of these two novel systems, which should have general utility in studying Drosophila biology and in using the fly as a model for human disease...
  35. pmc Structure and topology of microbial communities in the major gut compartments of Melolontha melolontha larvae (Coleoptera: Scarabaeidae)
    Markus Egert
    Max Planck Institute for Terrestrial Microbiology, Karl von Frisch Strasse, 35043 Marburg, Germany
    Appl Environ Microbiol 71:4556-66. 2005
    ..and the composition and topology of the intestinal microbiota in the major gut compartments of the root-feeding larva of the European cockchafer (Melolontha melolontha) were studied...
  36. doi Chitosan/double-stranded RNA nanoparticle-mediated RNA interference to silence chitin synthase genes through larval feeding in the African malaria mosquito (Anopheles gambiae)
    X Zhang
    Department of Entomology and Arthropod Genomics Center, Kansas State University, Manhattan, KS 66506, USA
    Insect Mol Biol 19:683-93. 2010
    ..These results suggest great potential for using such a nanoparticle-based RNAi technology for high-throughput screening of gene functions and for developing novel strategies for pest management...
  37. pmc Regulation and function of Arabidopsis JASMONATE ZIM-domain genes in response to wounding and herbivory
    Hoo Sun Chung
    Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, MI 48824, USA
    Plant Physiol 146:952-64. 2008
    ..Our results also indicate that the timing of JA-induced transcription in response to wounding is more rapid than previously realized...
  38. pmc The odorant binding protein gene family from the genome of silkworm, Bombyx mori
    Da Ping Gong
    The Key Sericultural Laboratory of Agricultural Ministry, Southwest University, Chongqing, PR China
    BMC Genomics 10:332. 2009
    ..Insect chemoreception is mediated by two large and diverse gene superfamilies, chemoreceptors and odorant binding proteins (OBPs). OBPs are believed to transport hydrophobic odorants from the environment to the olfactory receptors...
  39. pmc Hemolymph sugar homeostasis and starvation-induced hyperactivity affected by genetic manipulations of the adipokinetic hormone-encoding gene in Drosophila melanogaster
    Gyunghee Lee
    Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, Tennessee 37996, USA
    Genetics 167:311-23. 2004
    ..the AKH neurons indicated that AKH has multiple target tissues as follows: the prothoracic gland and aorta in the larva and the crop and brain in the adult...
  40. doi Insecticide resistance and its association with target-site mutations in natural populations of Anopheles gambiae from eastern Uganda
    Urvashi Ramphul
    Vector Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Trans R Soc Trop Med Hyg 103:1121-6. 2009
    ..Intriguingly, the association between DDT resistance and the presence of L1014S is consistent with a co-dominant effect, with heterozygous individuals showing an intermediate phenotype...
  41. ncbi Recruitment of entomopathogenic nematodes by insect-damaged maize roots
    Sergio Rasmann
    University of Neuchatel, Institute of Zoology, Laboratory of Animal Ecology and Entomology, CP 2, CH 2007 Neuchatel, Switzerland
    Nature 434:732-7. 2005
    ..Development of new varieties that release the attractant in adequate amounts should help enhance the efficacy of nematodes as biological control agents against root pests like D. v. virgifera...
  42. doi The biology of coral metamorphosis: molecular responses of larvae to inducers of settlement and metamorphosis
    L C Grasso
    Centre for the Molecular Genetics of Development, Molecular Genetics and Evolution Group, Research School of Biological Sciences, Australian National University, P O Box 475, Canberra, ACT, 2612, Australia
    Dev Biol 353:411-9. 2011
    Like many other cnidarians, corals undergo metamorphosis from a motile planula larva to a sedentary polyp...
  43. pmc Late-acting dominant lethal genetic systems and mosquito control
    Hoang Kim Phuc
    Department of Zoology, University of Oxford, South Parks Road, Oxford, UK
    BMC Biol 5:11. 2007
    ..Additionally, vector populations with strong density-dependent effects will tend to be resistant to SIT-based control as the population-reducing effect of induced sterility will tend to be offset by reduced density-dependent mortality...
  44. doi Vesicular glutamate transporter 3 is required for synaptic transmission in zebrafish hair cells
    Nikolaus Obholzer
    Howard Hughes Medical Institute, Oregon Hearing Research Center and Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Neurosci 28:2110-8. 2008
    ..Lack of postsynaptic action currents in the mutants suggests that the remaining hair-cell synaptic vesicles contain insufficient levels of glutamate for generation of action potentials in first-order neurons...
  45. ncbi A hormonal signaling pathway influencing C. elegans metabolism, reproductive development, and life span
    B Gerisch
    Max Planck Institut fur Molekulare Genetik, Ihnestr 73, D 14195 Berlin, Germany
    Dev Cell 1:841-51. 2001
    ..Sensory neurons, hypodermis, and somatic gonadal cells expressing daf-9 identify potential endocrine tissues. Evidently, lipophilic hormones influence nematode metabolism, diapause, and life span...
  46. doi A chemical enterocolitis model in zebrafish larvae that is dependent on microbiota and responsive to pharmacological agents
    Stefan H Oehlers
    Department of Molecular Medicine and Pathology, School of Medical Sciences, The University of Auckland, Auckland, New Zealand
    Dev Dyn 240:288-98. 2011
    ..This system will be useful to rapidly interrogate in vivo the biological significance of the IBD candidate genes so far identified and to carry out pharmacological modifier screens...
  47. pmc Highly focused anopheline breeding sites and malaria transmission in Dakar
    Vanessa Machault
    Unité d entomologie médicale, Equipe 7 Maladies Emergentes et Moustiques, Institut de Medecine Tropicale du Service de Sante des Armees, Allée du Médecin Colonel Jamot, Parc du Pharo, 13262 Marseille cedex 07, France
    Malar J 8:138. 2009
    ....
  48. ncbi Specialized hepatocyte-like cells regulate Drosophila lipid metabolism
    Eugenio Gutierrez
    Medical Research Council, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Nature 445:275-80. 2007
    ..These findings provide evidence that some lipid-processing functions of the mammalian liver are performed in insects by oenocytes...
  49. pmc Active sampling and decision making in Drosophila chemotaxis
    Alex Gomez-Marin
    EMBL CRG Systems Biology Unit, Center for Genomic Regulation CRG and UPF, 08003 Barcelona, Spain
    Nat Commun 2:441. 2011
    ..Our findings suggest that larval chemotaxis represents an intermediate navigation strategy between the biased random walks of Escherichia Coli and the stereo-olfaction observed in rats and humans...
  50. doi The insect neuropeptide PTTH activates receptor tyrosine kinase torso to initiate metamorphosis
    Kim F Rewitz
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Science 326:1403-5. 2009
    ..We conclude that PTTH initiates metamorphosis by activation of the Torso/ERK pathway...
  51. pmc Nociceptive neurons protect Drosophila larvae from parasitoid wasps
    Richard Y Hwang
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Curr Biol 17:2105-16. 2007
    ..In response, the larvae "roll" with a motor pattern that is completely distinct from the style of locomotion that is used for foraging...
  52. pmc Predation efficiency of Anopheles gambiae larvae by aquatic predators in western Kenya highlands
    Eliningaya J Kweka
    Centre for Global Health Research, Kenya Medical Research Institute, P O Box 1578, Kisumu 40100, Kenya
    Parasit Vectors 4:128. 2011
    ..In the current study, we examined the predation efficiency of five predators on Anopheles gambiae s.s larvae in 24 hour and semi- field evaluations...
  53. doi Wax moth larva (Galleria mellonella): an in vivo model for assessing the efficacy of antistaphylococcal agents
    Andrew P Desbois
    Biomedical Sciences Research Complex, School of Biology, The North Haugh, University of St Andrews, Fife, KY16 9ST, UK
    J Antimicrob Chemother 66:1785-90. 2011
    To investigate whether the wax moth larva, Galleria mellonella, is a suitable host for assessing the in vivo efficacy of antistaphylococcal agents against Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) infections.
  54. doi Effect of temperature and inter-specific competition on the development and survival of Anopheles gambiae sensu stricto and An. arabiensis larvae
    Matthew J Kirby
    School of Biological and Biomedical Sciences, Durham University, Science Laboratories, UK
    Acta Trop 109:118-23. 2009
    ..The development time from first instar larva to adult at constant water temperatures (25, 30 and 35 degrees C) was measured in these two species when reared ..
  55. pmc Prothoracicotropic hormone regulates developmental timing and body size in Drosophila
    Zofeyah McBrayer
    The Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Dev Cell 13:857-71. 2007
    ..These results indicate that final body size in insects is determined by a balance between growth-rate regulators such as insulin and developmental timing cues such as PTTH that set the duration of the feeding interval...
  56. ncbi Herbivory: caterpillar saliva beats plant defences
    Richard O Musser
    Department of Entomology, University of Arkansas, Fayetteville, Arkansas 72701, USA
    Nature 416:599-600. 2002
    ..We find that the enzyme glucose oxidase counteracts the production of nicotine induced by the caterpillar feeding on the plant...
  57. doi Pyrosequencing the Manduca sexta larval midgut transcriptome: messages for digestion, detoxification and defence
    Y Pauchet
    School of Biosciences, University of Exeter, Cornwall Campus, Penryn, UK
    Insect Mol Biol 19:61-75. 2010
    ..Similar studies of other tissues will allow for a tissue by tissue description of the M. sexta transcriptome and will form an essential complimentary step on the road to genome sequencing and annotation...
  58. ncbi Enhanced locomotion caused by loss of the Drosophila DEG/ENaC protein Pickpocket1
    Joshua A Ainsley
    Department of Physiology and Biophysics, University of Iowa, Roy J and Lucille A Carver College of Medicine, Iowa City, IA 52242, USA
    Curr Biol 13:1557-63. 2003
    ....
  59. ncbi The Tribolium chitin synthase genes TcCHS1 and TcCHS2 are specialized for synthesis of epidermal cuticle and midgut peritrophic matrix
    Y Arakane
    USDA ARS Grain Marketing and Production Research Center, Manhattan, KS 66502, USA
    Insect Mol Biol 14:453-63. 2005
    ..However, RNAi-mediated down-regulation of TcCHS2, but not TcCHS1, led to cessation of feeding, a dramatic shrinkage in larval size and reduced chitin content in the midgut...
  60. ncbi Density-dependent development of Anopheles gambiae (Diptera: Culicidae) larvae in artificial habitats
    John E Gimnig
    Vector Biology and Control Research Centre, Kenya Medical Research Institute, Kisumu
    J Med Entomol 39:162-72. 2002
    ..020 d and female dry mass decreased by 0.74 microg with each additional larva. By fitting the data to the pupation window model, the estimated minimum dry mass to achieve pupation was 0...
  61. ncbi Swimming of larval zebrafish: ontogeny of body waves and implications for locomotory development
    Ulrike K Müller
    Wageningen University, Experimental Zoology Group, Marijkeweg 40, 6709 PG Wageningen, The Netherlands
    J Exp Biol 207:853-68. 2004
    ..2) and strain rates (up to 30 s(-1) in white muscle fibres) yet are able to power swimming for several seconds...
  62. ncbi Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells
    Joerg Betschinger
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, Dr Bohr Gasse 3 5, 1030 Vienna, Austria
    Cell 124:1241-53. 2006
    ..Similar defects are seen in lethal giant larvae (lgl) mutants where Brat and Prospero are not asymmetric. We have identified a molecular mechanism that may control self-renewal and prevent tumor formation in other stem cells as well...
  63. doi RNA interference-mediated knockdown of a cytochrome P450, CYP6BG1, from the diamondback moth, Plutella xylostella, reduces larval resistance to permethrin
    Ma Anita M Bautista
    Laboratory of Applied Entomology, Graduate School of Bioagricultural Sciences, Nagoya University, Furo cho, Chikusa ku, Nagoya, Japan
    Insect Biochem Mol Biol 39:38-46. 2009
    ..xylostella strain did not lead to changes in the level of resistance to permethrin, supporting further the specific involvement of CYP6BG1 in the resistance...
  64. ncbi bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila
    Julius Brennecke
    European Molecular Biology Laboratory, Meyerhofstr 1, 69117 Heidelberg, Germany
    Cell 113:25-36. 2003
    ..bantam microRNA simultaneously stimulates cell proliferation and prevents apoptosis. We identify the pro-apoptotic gene hid as a target for regulation by bantam miRNA, providing an explanation for bantam's anti-apoptotic activity...
  65. pmc The role of the TRP channel NompC in Drosophila larval and adult locomotion
    Li E Cheng
    Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94158, USA
    Neuron 67:373-80. 2010
    ..Taken together, our findings suggest that NompC mediates proprioception in locomotion and support its role as a mechanosensitive channel...
  66. pmc Light-avoidance-mediating photoreceptors tile the Drosophila larval body wall
    Yang Xiang
    Howard Hughes Medical Institute, Departments of Physiology, Biochemistry, and Biophysics, University of California San Francisco, San Francisco, California 94158, USA
    Nature 468:921-6. 2010
    ..These novel photoreceptors use phototransduction machinery distinct from other photoreceptors in Drosophila and enable larvae to sense light exposure over their entire bodies and move out of danger...
  67. doi Bacteriophages encode factors required for protection in a symbiotic mutualism
    Kerry M Oliver
    Department of Entomology, University of Georgia, Athens, GA 30602, USA
    Science 325:992-4. 2009
    ..Thus, phages vector ecologically important traits, such as defense against parasitoids, within and among symbiont and animal host lineages...
  68. pmc Identifying the most productive breeding sites for malaria mosquitoes in The Gambia
    Ulrike Fillinger
    Disease Control and Vector Biology Unit, London School of Hygiene and Tropical Medicine, London, UK
    Malar J 8:62. 2009
    ..This study aimed to determine the characteristics of larval habitats most frequently and most densely populated by anopheline larvae and to estimate the numbers of adults produced in different habitats...
  69. pmc TGF-beta signaling is required for multiple processes during Xenopus tail regeneration
    Diana M Ho
    Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA 02115, USA
    Dev Biol 315:203-16. 2008
    ....
  70. pmc New records of Anopheles arabiensis breeding on the Mount Kenya highlands indicate indigenous malaria transmission
    Hong Chen
    Program in Public Health, College of Health Sciences, University of California, Irvine, CA 92697, USA
    Malar J 5:17. 2006
    ..Determination of presence and abundance of malaria vector is vital for effective control and epidemic risk assessment of malaria among both local residents and tourists...
  71. pmc Aging and resistance to oxidative damage in Caenorhabditis elegans
    P L Larsen
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    Proc Natl Acad Sci U S A 90:8905-9. 1993
    The dauer larva state and the age-1 mutation, both of which extend life-span in Caenorhabditis elegans, were tested for hyperresistance to cellular damage that may be relevant to aging...
  72. pmc Compensatory proliferation in Drosophila imaginal discs requires Dronc-dependent p53 activity
    Brent S Wells
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Curr Biol 16:1606-15. 2006
    ..Here we provide evidence that Drosophila p53 (dp53) has a previously unidentified role in coordinating the compensatory growth response to tissue damage...
  73. pmc Community-based environmental management for malaria control: evidence from a small-scale intervention in Dar es Salaam, Tanzania
    Marcia C Castro
    Department of Global Health and Population, Harvard School of Public Health, 665 Huntington Avenue, Bldg, I, Room 1113, Boston, MA 02115, USA
    Malar J 8:57. 2009
    ..After community sensitization, two drains were cleaned followed by maintenance. This paper assessed the impact of the intervention on community awareness, prevalence of malaria infection, and Anopheles larval presence in drains...
  74. doi Early requirement of Hyaluronan for tail regeneration in Xenopus tadpoles
    Esteban G Contreras
    Center for Aging and Regeneration, Center for Cell Regulation and Pathology, Faculty of Biological Sciences, P Universidad Catolica de Chile, Alameda 340, Santiago, Chile
    Development 136:2987-96. 2009
    ..In addition, a crosstalk between HA and GSK3beta signaling during tail regeneration was demonstrated...
  75. pmc A dp53-dependent mechanism involved in coordinating tissue growth in Drosophila
    Duarte Mesquita
    Institute for Research in Biomedicine, Barcelona, Spain
    PLoS Biol 8:e1000566. 2010
    ....
  76. pmc The four hexamerin genes in the honey bee: structure, molecular evolution and function deduced from expression patterns in queens, workers and drones
    Juliana R Martins
    Faculdade de Medicina de Ribeirao Preto, Departamento de Genetica, Universidade de Sao Paulo, Ribeirao Preto, SP, Brazil
    BMC Mol Biol 11:23. 2010
    ....
  77. pmc Characterization of Drosophila melanogaster cytochrome P450 genes
    Henry Chung
    Centre for Environmental Stress and Adaptation Research, Department of Genetics, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Victoria, 3010, Australia
    Proc Natl Acad Sci U S A 106:5731-6. 2009
    ....
  78. pmc Juvenile hormone resistance gene Methoprene-tolerant controls entry into metamorphosis in the beetle Tribolium castaneum
    Barbora Konopova
    Department of Molecular Biology, University of South Bohemia, and Biology Center, Czech Academy of Sciences, 37005 Ceske Budejovice, Czech Republic
    Proc Natl Acad Sci U S A 104:10488-93. 2007
    ..Our results demonstrate that TcMet functions in JH response and provide the critical evidence that the putative JH receptor Met mediates the antimetamorphic effect of JH...
  79. pmc Advantages of larval control for African malaria vectors: low mobility and behavioural responsiveness of immature mosquito stages allow high effective coverage
    Gerry F Killeen
    Department of Tropical Medicine, School of Public Health and Tropical Medicine, Tulane University Health Sciences Centre, 1430 Tulane Avenue, New Orleans, Louisiana 70112, USA
    Malar J 1:8. 2002
    ....
  80. doi Comparative proteome and phosphoproteome analyses during cyprid development of the barnacle Balanus (=Amphibalanus) amphitrite
    Yu Zhang
    KAUST Global Collaborative Research Program, Department of Biology, The Hong Kong University of Science and Technology, Hong Kong SAR, China
    J Proteome Res 9:3146-57. 2010
    ..It has a complex life cycle during which the larva (called a nauplius) molts six times before transforming into the cyprid stage. The cyprid stage in B...
  81. ncbi Specification of Drosophila hematopoietic lineage by conserved transcription factors
    T Lebestky
    Molecular Biology Institute, Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, CA 90095, USA
    Science 288:146-9. 2000
    ..Given the similarities of Srp and Lz to mammalian GATA and AML1 proteins, observations in Drosophila are likely to have broad implications for understanding mammalian hematopoiesis and leukemias...
  82. pmc Relevant microclimate for determining the development rate of malaria mosquitoes and possible implications of climate change
    Krijn P Paaijmans
    Laboratory of Entomology, Wageningen University, PO Box 8031, 6700EH Wageningen, The Netherlands
    Malar J 9:196. 2010
    ..Many process-based models use mean air temperature to estimate larval development times, and hence adult vector densities and/or malaria risk...
  83. pmc Proteomic identification of differentially expressed and phosphorylated proteins in epidermis involved in larval-pupal metamorphosis of Helicoverpa armigera
    Qiang Fu
    School of Life Sciences, The Key Laboratory of Plant Cell Engineering and Germplasm Innovation, Ministry of Education, Shandong University, Jinan, 250100, PR China
    BMC Genomics 10:600. 2009
    ..Metamorphosis is an important process in the life cycle of holometabolous insects and is regulated by insect hormones. During metamorphosis, the epidermis goes through a significant transformation at the biochemical and molecular levels...
  84. doi Rapid transcriptome and proteome profiling of a non-model marine invertebrate, Bugula neritina
    Hao Wang
    Department of Biology, Hong Kong University of Science and Technology, Hong Kong SAR, P R China
    Proteomics 10:2972-81. 2010
    ..Furthermore, we demonstrated, for the first time, the combined use of two high-throughput technologies as a powerful approach for accelerating the studies of non-model but otherwise important species...
  85. ncbi Light stimulates a transducin-independent increase of cytoplasmic Ca2+ and suppression of current in cones from the zebrafish mutant nof
    Susan E Brockerhoff
    Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 23:470-80. 2003
    ..Thus, in addition to stimulating transducin, light also independently induces release of Ca2+ into the photoreceptor cytoplasm...
  86. ncbi Co(i)-ordinating defenses: NaCOI1 mediates herbivore- induced resistance in Nicotiana attenuata and reveals the role of herbivore movement in avoiding defenses
    Anja Paschold
    Max Planck Institute for Chemical Ecology, Department of Molecular Ecology, Hans Knoll Strasse 8, 07745 Jena, Germany
    Plant J 51:79-91. 2007
    ..We conclude that NaCOI1 is essential for induced resistance in N. attenuata, and that ir-coi1 plants highlight the benefits of herbivore movement for avoiding induced defenses...
  87. doi Xenopus Wnt-5a induces an ectopic larval tail at injured site, suggesting a crucial role for noncanonical Wnt signal in tail regeneration
    Takuji Sugiura
    Department of Life Science, Graduate School of Science, Himeji Institute of Technology, Kamigori Akou, Hyogo 678 1297, Japan
    Mech Dev 126:56-67. 2009
    ..A pharmacological study showed that JNK signaling is required in tail regeneration. These results support the proposition that Xwnt-5a plays an instructive role in larval tail regeneration via Wnt/JNK signaling...
  88. ncbi Transmission of Batrachochytrium dendrobatidis within and between amphibian life stages
    Lara J Rachowicz
    Department of Integrative Biology, University of California, Berkeley, California 94720 3140, USA
    Dis Aquat Organ 61:75-83. 2004
    ..In addition, we provide guidelines for visually detecting B. dendrobatidis in R. muscosa tadpoles, which may be useful in other affected species. Field surveys of infected and uninfected populations verify this identification technique...
  89. pmc Diversity cascades and malaria vectors
    John C Carlson
    Department of Pediatrics, Tulane University, New Orleans, LA 70112, USA
    J Med Entomol 46:460-4. 2009
    ..gambiae populations. The increase in vector abundance as a result of reduced predator diversity highlights the public health value in conserving native insect diversity...
  90. pmc Insecticide resistance resulting from an absence of target-site gene product
    T G Wilson
    Department of Biology, Colorado State University, Fort Collins, CO 80523, USA
    Proc Natl Acad Sci U S A 95:14040-4. 1998
    ....
  91. doi Protein kinase C signalling during miracidium to mother sporocyst development in the helminth parasite, Schistosoma mansoni
    Marthe H R Ludtmann
    School of Life Sciences, Kingston University, Penrhyn Road, Kingston upon Thames, Surrey KT1 2EE, UK
    Int J Parasitol 39:1223-33. 2009
    ..These results highlight the dynamic nature of PKC signalling during S. mansoni postembryonic development and support a role for active PKC in restricting transformation of S. mansoni miracidia into mother sporocysts...
  92. pmc Habitat stability and occurrences of malaria vector larvae in western Kenya highlands
    Yousif E Himeidan
    Centre for Global Health Research, Kenya Medical Research Institute KEMRI, P O Box 1578, Kisumu 40100, Kenya
    Malar J 8:234. 2009
    ..Given that most inhabitants of the highlands actually dwell in the uphill regions, it is important to develop understanding of mosquito breeding habitat stability in these sites in order to determine their potential for larval control...
  93. pmc Shellfish face uncertain future in high CO2 world: influence of acidification on oyster larvae calcification and growth in estuaries
    A Whitman Miller
    Smithsonian Environmental Research Center, Edgewater, Maryland, United States of America
    PLoS ONE 4:e5661. 2009
    ....
  94. pmc Effects of a five-year citywide intervention program to control Aedes aegypti and prevent dengue outbreaks in northern Argentina
    Ricardo E Gürtler
    Laboratorio de Eco Epidemiología, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
    PLoS Negl Trop Dis 3:e427. 2009
    ..Dengue has propagated widely through the Americas. Most countries have not been able to maintain permanent larval mosquito control programs, and the long-term effects of control actions have rarely been documented...
  95. ncbi Efficacy of Aquatain, a monomolecular surface film, against the malaria vectors Anopheles stephensi and An. gambiae s.s. in the laboratory
    Tullu Bukhari
    Laboratory of Entomology, Wageningen University and Research Centre, Wageningen, The Netherlands
    Am J Trop Med Hyg 80:758-63. 2009
    ..This physical control method has the potential to become a safe, cost-effective, and resistance-proof malaria vector control tool...
  96. ncbi Cornea-lens transdifferentiation in the anuran, Xenopus tropicalis
    J J Henry
    Department of Cell and Structural Biology, University of Illinois, 601 South Goodwin Avenue, Urbana, IL 61801, USA
    Dev Genes Evol 211:377-87. 2001
    ..These findings are discussed in terms of the evolution of this developmental process within the anurans...
  97. ncbi Olfactory coding in Drosophila larvae investigated by cross-adaptation
    Jennefer Boyle
    Faculty of Life Sciences, The University of Manchester, Oxford Road, Manchester M13 9PT, UK
    J Exp Biol 208:3483-91. 2005
    ..These findings are discussed in light of the possible intra- and intercellular mechanisms of adaptation and the advantage of altered sensitivity for the larva.
  98. doi The insulin signaling pathway in honey bee (Apis mellifera) caste development - differential expression of insulin-like peptides and insulin receptors in queen and worker larvae
    Sergio Vicente de Azevedo
    Universidade de São Paulo Faculdade de Medicina de Ribeirão Preto, Biologia Celular e Molecular e Bioagentes Patogenicos, Avenida Bandeirantes 3900, 14049 900 Ribeirao Preto, SP Brazil
    J Insect Physiol 54:1064-71. 2008
    ....
  99. pmc Localized olfactory representation in mushroom bodies of Drosophila larvae
    Liria M Masuda-Nakagawa
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan
    Proc Natl Acad Sci U S A 106:10314-9. 2009
    ..Stereotypic representation of single OSN input in calyx glomeruli provides a mechanism for MB neurons to detect and discriminate olfactory cues...
  100. ncbi Induction of cAMP response element-binding protein-dependent medium-term memory by appetitive gustatory reinforcement in Drosophila larvae
    Ken Honjo
    Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba 305 8572, Japan
    J Neurosci 25:7905-13. 2005
    ..In contrast, the Drosophila larva has a simple brain with uniquely identifiable neural networks, providing an opportunity of an attractive ..
  101. doi Transstadial and horizontal transfer of bacteria within a colony of Anopheles gambiae (Diptera: Culicidae) and oviposition response to bacteria-containing water
    J M Lindh
    Department of Genetics, Microbiology and Toxicology, Stockholm University, Stockholm S 10691, Sweden
    Acta Trop 107:242-50. 2008
    ..Further research is needed to determine if the bacteria are also transferred in the same way in nature...

Research Grants85

  1. HEAT SHOCK PROTEIN GP96 AND IMMUNITY
    Nicholas Cohen; Fiscal Year: 2003
    ..Experiments to evaluate the specificity and peptide complex-dependency of these putative alloimmune reactivities are presented as are experiments to reveal the nature of effector cells involved. ..
  2. Functional Genomic Approach to Macrofilaricide Discovery
    James McCarter; Fiscal Year: 2007
    ..Filarial parasites cause some of the more pernicious nematode-borne diseases known (elephantiasis and river blindness). ..
  3. IMMUNOBIOLOGY OF SCHISTOSOME-MOLLUSC INTERACTIONS
    Timothy P Yoshino; Fiscal Year: 2010
    ..Therefore, knowledge gained from the proposed studies could very well lead to the development of more effective and novel methods for controlling human schistosome transmission by disrupting parasite development within the snail host. ..
  4. TRYPTOPHAN METABOLISM IN MOSQUITOES
    Jianyong Li; Fiscal Year: 2002
    ..abstract_text> ..
  5. Targeted Manipulation of the Zebrafish Genome through Homologous Recombination
    Brian Ciruna; Fiscal Year: 2010
    ....
  6. Targeted Manipulation of the Zebrafish Genome through Homologous Recombination
    Brian Ciruna; Fiscal Year: 2009
    ....
  7. Synaptic target selection in Drosophila
    KAI G ZINN; Fiscal Year: 2010
    ..Knowledge about wiring mechanisms may help researchers to understand diseases in which neuronal connectivity patterns are altered. These include schizophrenia and autism. ..
  8. Tsetse Fecundity Reduction for Trypanosomiasis Control
    Serap Aksoy; Fiscal Year: 2010
    ..an unusual reproductive biology as they only develop one offspring at a time and give birth to a fully developed larva. Reproduction in tsetse is also unique in that it requires the presence of obligate mutualist symbiotic bacteria...
  9. Tsetse Fecundity Reduction for Trypanosomiasis Control
    Serap Aksoy; Fiscal Year: 2010
    ..an unusual reproductive biology as they only develop one offspring at a time and give birth to a fully developed larva. Reproduction in tsetse is also unique in that it requires the presence of obligate mutualist symbiotic bacteria...
  10. PROTECTIVE IMMUNITY IN HUMANS AGAINST O VOLVULUS LARVAE
    Sara Lustigman; Fiscal Year: 2001
    ..These studies should, therefore, be instrumental in developing a vaccine against onchocerciasis with anticipated clinical application. ..
  11. ENDOCRINOLOGY OF MOSQUITO REPRODUCTION
    Mark Brown; Fiscal Year: 1999
    ..As well, both the ecdysteroidogenic hormones and their receptors will provide promising targets for genetic manipulation, once it is possible to genetically transform mosquitoes. ..
  12. The development of a recombinant vaccine against human onchocerciasis
    Sara Lustigman; Fiscal Year: 2010
    ..volvulus infective larvae being a most important new tool and essential additional component in the effort to control onchocerciasis. ..
  13. The development of a recombinant vaccine against human onchocerciasis
    Sara Lustigman; Fiscal Year: 2009
    ..volvulus infective larvae being a most important new tool and essential additional component in the effort to control onchocerciasis. ..
  14. IMMUNITY TO PARASITIC INFECTION
    Judith Appleton; Fiscal Year: 1992
    ..We would investigate the need for ancillary cells as well as IgE antibodies to facilitate expression of rapid expulsion by the adult...
  15. IMMUNOBIOLOGY OF SCHISTOSOME/MOLLUSC INTERACTIONS
    TIMOTHY YOSHINO; Fiscal Year: 2007
    ....
  16. HUMAN STRONGYLOIDIASIS--DEVELOPMENT OF A CANINE MODEL
    Gerhard Schad; Fiscal Year: 1992
    ..Intestinal and other tissues will be examined biochemically, histologically, and immunologically to assess the role of mast cells in regulating the parasite's abundance and distribution...
  17. MOLECULAR PHYSIOLOGY OF THE EPITRACHEAL ENDOCRINE SYSTEM
    Michael Adams; Fiscal Year: 2001
    Insect development from larva to adult depends on the repeated shedding of old cuticle via a highly stereotyped behavior called ecdysis...
  18. LYME DISEASE IN WESTERN USA: ECOLOGY AND EPIDEMIOLOGY
    Robert Lane; Fiscal Year: 2007
    ..Development of this risk model, which culminates over 2 decades of intensive study, should contribute significantly to our knowledge of the landscape ecology and epidemiology of LD in this region. ..
  19. A feasibility study of genetically encoded fluorescent gold nanoclusters
    Jan Liphardt; Fiscal Year: 2009
    ..To ensure public health significance, much of the research will involve zebrafish, a vertebrate animal model system for an increasing number of human diseases. ..
  20. LARVAL MOSQUITO FEEDING AND MICROBIAL INTERACTIONS
    Edward Walker; Fiscal Year: 1993
    ....
  21. Reprogramming Cells to Enable Limb Regeneration
    JONATHAN M SLACK; Fiscal Year: 2010
    ..This innovative proposal will use modern stem cell technology to test a hypothesis about why this is so. If the hypothesis is confirmed, the methods developed should assist in facilitating the regeneration of mammalian limbs. ..
  22. NEUROIMMUNOLOGY AND PATHOLOGY OF NEUROCYSTICERCOSIS
    JUDY TEALE; Fiscal Year: 1999
    ..Finally, she will utilize a variety of gene knock-out mice (IL4, IL10, TGFb, E-selectin, CD40 and IFNg knock outs will be available for study). ..
  23. Synaptic target selection in Drosophila
    KAI G ZINN; Fiscal Year: 2010
    ..abstract_text> ..
  24. Signaling Mechanisms in Drosophila Neural Development
    Kai Zinn; Fiscal Year: 2007
    ..We will also search for enhancers and suppressors of a bchs GOF eye phenotype. Candidate genes from the eye screen will be tested for modification of the bchs GOF neuromuscular phenotype and for interaction with bchs LOF mutations. ..