larva

Summary

Summary: Wormlike or grublike stage, following the egg in the life cycle of insects, worms, and other metamorphosing animals.

Top Publications

  1. pmc Anopheles gambiae: historical population decline associated with regional distribution of insecticide-treated bed nets in western Nyanza Province, Kenya
    M Nabie Bayoh
    Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, 48824, USA
    Malar J 9:62. 2010
  2. pmc A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish
    Philipp Niethammer
    Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 459:996-9. 2009
  3. ncbi daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans
    K D Kimura
    Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Science 277:942-6. 1997
  4. pmc Brain-wide neuronal dynamics during motor adaptation in zebrafish
    Misha B Ahrens
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nature 485:471-7. 2012
  5. ncbi Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes
    Eric J Rulifson
    Department of Developmental Biology, Beckman Center B300, Stanford University, Stanford, CA 94305 5329, USA
    Science 296:1118-20. 2002
  6. pmc An internal thermal sensor controlling temperature preference in Drosophila
    Fumika N Hamada
    National Center for Behavioral Genomics, Volen Center for Complex Systems, Biology Department, Brandeis University MS 008, 415 South Street, Waltham, Massachusetts 02454, USA
    Nature 454:217-20. 2008
  7. ncbi Simultaneous identification of species and molecular forms of the Anopheles gambiae complex by PCR-RFLP
    C Fanello
    London School of Hygiene and Tropical Medicine, London, UK
    Med Vet Entomol 16:461-4. 2002
  8. ncbi Remote control of insulin secretion by fat cells in Drosophila
    Charles Geminard
    Institute for Developmental Biology and Cancer, CNRS University of Nice Sophia Antipolis, Parc Valrose, 06108 Nice, France
    Cell Metab 10:199-207. 2009
  9. pmc The role of Drosophila Piezo in mechanical nociception
    Sung Eun Kim
    Department of Cell Biology, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, California 92037, USA
    Nature 483:209-12. 2012
  10. ncbi Conditional modification of behavior in Drosophila by targeted expression of a temperature-sensitive shibire allele in defined neurons
    T Kitamoto
    Division of Neurosciences, Beckman Research Institute of the City of Hope, 1450 East Duarte Road, Duarte, California 91010, USA
    J Neurobiol 47:81-92. 2001

Detail Information

Publications307 found, 100 shown here

  1. pmc Anopheles gambiae: historical population decline associated with regional distribution of insecticide-treated bed nets in western Nyanza Province, Kenya
    M Nabie Bayoh
    Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, 48824, USA
    Malar J 9:62. 2010
    ..l.) species complex, namely A. gambiae sensu stricto (s.s.) and Anopheles arabiensis. Historically, the former species was proportionately dominant in indoor resting collections of females...
  2. pmc A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish
    Philipp Niethammer
    Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 459:996-9. 2009
    ..This is the first observation, to our knowledge, of a tissue-scale H(2)O(2) pattern, and the first evidence that H(2)O(2) signals to leukocytes in tissues, in addition to its known antiseptic role...
  3. ncbi daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans
    K D Kimura
    Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Science 277:942-6. 1997
    ..Life-span regulation by insulin-like metabolic control is analogous to mammalian longevity enhancement induced by caloric restriction, suggesting a general link between metabolism, diapause, and longevity...
  4. pmc Brain-wide neuronal dynamics during motor adaptation in zebrafish
    Misha B Ahrens
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nature 485:471-7. 2012
    ..Lesions to the inferior olive indicate a specific functional role for olivocerebellar circuitry in adaptive locomotion. This study enables the analysis of brain-wide dynamics at single-cell resolution during behaviour...
  5. ncbi Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes
    Eric J Rulifson
    Department of Developmental Biology, Beckman Center B300, Stanford University, Stanford, CA 94305 5329, USA
    Science 296:1118-20. 2002
    ..Interestingly, the phenotype of flies lacking IPCs includes certain features of diabetes mellitus...
  6. pmc An internal thermal sensor controlling temperature preference in Drosophila
    Fumika N Hamada
    National Center for Behavioral Genomics, Volen Center for Complex Systems, Biology Department, Brandeis University MS 008, 415 South Street, Waltham, Massachusetts 02454, USA
    Nature 454:217-20. 2008
    ..This provides a potentially general strategy for robustly selecting a narrow temperature range optimal for survival...
  7. ncbi Simultaneous identification of species and molecular forms of the Anopheles gambiae complex by PCR-RFLP
    C Fanello
    London School of Hygiene and Tropical Medicine, London, UK
    Med Vet Entomol 16:461-4. 2002
    ..This procedure is more efficient, faster and cheaper than those used before, so is recommended for large-scale processing of field-collected larval and adult specimens to be identified in malaria vector studies...
  8. ncbi Remote control of insulin secretion by fat cells in Drosophila
    Charles Geminard
    Institute for Developmental Biology and Cancer, CNRS University of Nice Sophia Antipolis, Parc Valrose, 06108 Nice, France
    Cell Metab 10:199-207. 2009
    ..Thus, the availability of nutrients is remotely sensed in fat body cells and conveyed to the brain IPCs by a humoral signal controlling ILP release...
  9. pmc The role of Drosophila Piezo in mechanical nociception
    Sung Eun Kim
    Department of Cell Biology, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, California 92037, USA
    Nature 483:209-12. 2012
    ..These data demonstrate the physiological relevance of the Piezo family in mechanotransduction in vivo, supporting a role of Piezo proteins in mechanosensory nociception...
  10. ncbi Conditional modification of behavior in Drosophila by targeted expression of a temperature-sensitive shibire allele in defined neurons
    T Kitamoto
    Division of Neurosciences, Beckman Research Institute of the City of Hope, 1450 East Duarte Road, Duarte, California 91010, USA
    J Neurobiol 47:81-92. 2001
    ....
  11. ncbi Silencing a cotton bollworm P450 monooxygenase gene by plant-mediated RNAi impairs larval tolerance of gossypol
    Ying Bo Mao
    National Key Laboratory of Plant Molecular Genetics, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, P R China
    Nat Biotechnol 25:1307-13. 2007
    ....
  12. pmc Optogenetic dissection of a behavioural module in the vertebrate spinal cord
    Claire Wyart
    Helen Wills Neuroscience Institute and Department of Molecular and Cell Biology, University of California in Berkeley, Berkeley, California 94720, USA
    Nature 461:407-10. 2009
    ..Our results reveal that during early development in zebrafish these cells provide a positive drive to the spinal CPG for spontaneous locomotion...
  13. pmc Integrated malaria vector control with microbial larvicides and insecticide-treated nets in western Kenya: a controlled trial
    Ulrike Fillinger
    Disease Control and Vector Biology Unit, London School of Hygiene and Tropical Medicine, London, England
    Bull World Health Organ 87:655-65. 2009
    ....
  14. pmc Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in Drosophila
    Gabor Juhasz
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Genes Dev 21:3061-6. 2007
    ..Thus, normal levels of autophagy are crucial for stress survival and continuous cellular renewal, but not metamorphosis...
  15. pmc Field-evolved resistance to Bt maize by western corn rootworm
    Aaron J Gassmann
    Department of Entomology, Iowa State University, Ames, Iowa, United States of America
    PLoS ONE 6:e22629. 2011
    ..However, the evolution of resistance could cut short these benefits. A primary pest targeted by Bt maize in the United States is the western corn rootworm Diabrotica virgifera virgifera (Coleoptera: Chrysomelidae)...
  16. pmc Toward an understanding of the molecular mechanisms of barnacle larval settlement: a comparative transcriptomic approach
    Zhang Fan Chen
    KAUST Global Collaborative Research Program, Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong SAR, China
    PLoS ONE 6:e22913. 2011
    ..The pyrosequencing-based transcriptomic approach is thought to be useful to identify key molecular changes during larval settlement...
  17. pmc Larval source management for malaria control in Africa: myths and reality
    Ulrike Fillinger
    Department of Disease Control, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Malar J 10:353. 2011
    ....
  18. pmc Galleria mellonella as a model system for studying Listeria pathogenesis
    Krishnendu Mukherjee
    Institute for Phytopathology and Applied Zoology, Justus Liebig University, Frankfurter Strasse 107, 35392 Giessen, Germany
    Appl Environ Microbiol 76:310-7. 2010
    ..isolated from a wide variety of settings from both the clinic and the environment...
  19. ncbi Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells
    Joerg Betschinger
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, Dr Bohr Gasse 3 5, 1030 Vienna, Austria
    Cell 124:1241-53. 2006
    ..Similar defects are seen in lethal giant larvae (lgl) mutants where Brat and Prospero are not asymmetric. We have identified a molecular mechanism that may control self-renewal and prevent tumor formation in other stem cells as well...
  20. ncbi Lactobacillus plantarum promotes Drosophila systemic growth by modulating hormonal signals through TOR-dependent nutrient sensing
    Gilles Storelli
    Institut de Biologie du Developpement de Marseille Luminy, CNRS UMR 6216 Aix Marseille Universités, 13288 Marseille, France
    Cell Metab 14:403-14. 2011
    ..Our results indicate that the intestinal microbiota should also be envisaged as a factor that influences the systemic growth of its host...
  21. pmc Fat cells reactivate quiescent neuroblasts via TOR and glial insulin relays in Drosophila
    Rita Sousa-Nunes
    Division of Developmental Neurobiology, Medical Research Council National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Nature 471:508-12. 2011
    ..This mechanism indicates that dietary nutrients and remote organs, as well as local niches, are key regulators of transitions in stem-cell behaviour...
  22. ncbi The BMP homolog Gbb provides a retrograde signal that regulates synaptic growth at the Drosophila neuromuscular junction
    Brian D McCabe
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Neuron 39:241-54. 2003
    ..These experiments reveal that a muscle-derived BMP retrograde signal participates in coordinating neuromuscular synapse development and growth...
  23. ncbi Scaling of connectivity in marine populations
    R K Cowen
    Marine Biology and Fisheries, Rosenstiel School of Marine and Atmospheric Science, University of Miami, 4600 Rickenbacker Causeway, Miami, FL 33149, USA
    Science 311:522-7. 2006
    ..The results reveal distinct regions of population isolation based on larval dispersal that also correspond to genetic and morphological clines observed across a range of marine organisms...
  24. pmc Diabetic larvae and obese flies-emerging studies of metabolism in Drosophila
    Keith D Baker
    Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112 5331, USA
    Cell Metab 6:257-66. 2007
    ....
  25. pmc Microbial colonization induces dynamic temporal and spatial patterns of NF-κB activation in the zebrafish digestive tract
    Michelle Kanther
    Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, North Carolina, USA
    Gastroenterology 141:197-207. 2011
    ..We used in vivo imaging and molecular approaches to analyze NF-κB activation in response to the commensal microbiota in transparent gnotobiotic zebrafish...
  26. ncbi Field-evolved resistance to Bt toxin Cry1Ac in the pink bollworm, Pectinophora gossypiella (Saunders) (Lepidoptera: Gelechiidae), from India
    Sanyasi Dhurua
    Division of Entomology, Indian Agricultural Research Institute, New Delhi, India
    Pest Manag Sci 67:898-903. 2011
    ..During the 2007-2008 and 2008-2009 seasons, pink bollworm populations in India were surveyed to evaluate their responses to Cry1Ac and seed powder containing Cry1Ac and Cry2Ab2...
  27. ncbi Postembryonic hematopoiesis in Drosophila
    R Lanot
    UPR 9022 du CNRS, Institut de Biologie Moleculaire et Cellulaire, 15 rue Rene Descartes, Strasbourg Cedex, 67084, France
    Dev Biol 230:243-57. 2001
    ..Cells within all lymph gland lobes, including prohemocytes from posterior lobes, massively differentiate into a new cell type specifically devoted to encapsulation, the lamellocyte...
  28. ncbi Bacteriophages encode factors required for protection in a symbiotic mutualism
    Kerry M Oliver
    Department of Entomology, University of Georgia, Athens, GA 30602, USA
    Science 325:992-4. 2009
    ..Thus, phages vector ecologically important traits, such as defense against parasitoids, within and among symbiont and animal host lineages...
  29. ncbi Modulation of locomotor activity in larval zebrafish during light adaptation
    Harold A Burgess
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6058, USA
    J Exp Biol 210:2526-39. 2007
    ..We propose that regulation of motor activity by photic stimuli in zebrafish larvae serves a behavioral goal of maximizing exposure to well lit environments optimal for feeding...
  30. ncbi Flies without centrioles
    Renata Basto
    The Gurdon Institute, Tennis Court Road, Cambridge CB2 1QN, UK
    Cell 125:1375-86. 2006
    ..Thus, centrioles are essential for the formation of centrosomes, cilia, and flagella, but, remarkably, they are not essential for most aspects of Drosophila development...
  31. ncbi Field-evolved insect resistance to Bt crops: definition, theory, and data
    Bruce E Tabashnik
    Department of Entomology, University of Arizona, Tucson, AZ 85721, USA
    J Econ Entomol 102:2011-25. 2009
    ....
  32. ncbi Bruchpilot promotes active zone assembly, Ca2+ channel clustering, and vesicle release
    Robert J Kittel
    European Neuroscience Institute Göttingen, Grisebachstrasse 5, 37077 Gottingen, Germany
    Science 312:1051-4. 2006
    ..BRP-like proteins seem to establish proximity between Ca2+ channels and vesicles to allow efficient transmitter release and patterned synaptic plasticity...
  33. ncbi Functionally unequal centrosomes drive spindle orientation in asymmetrically dividing Drosophila neural stem cells
    Elena Rebollo
    Cell Division Group, Institute for Research in Biomedicine, Parc Científic Barcelona, C Josep Samitier 1 5, 08028 Barcelona, Spain
    Dev Cell 12:467-74. 2007
    ..Apical aster maintenance requires the function of Pins. These results reveal that spindle orientation in Drosophila larval NBs is determined very early in the cell cycle, and is mediated by asymmetric centrosome function...
  34. ncbi Wax moth larva (Galleria mellonella): an in vivo model for assessing the efficacy of antistaphylococcal agents
    Andrew P Desbois
    Biomedical Sciences Research Complex, School of Biology, The North Haugh, University of St Andrews, Fife, KY16 9ST, UK
    J Antimicrob Chemother 66:1785-90. 2011
    To investigate whether the wax moth larva, Galleria mellonella, is a suitable host for assessing the in vivo efficacy of antistaphylococcal agents against Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) infections.
  35. ncbi Connectivity of marine populations: open or closed?
    R K Cowen
    Rosenstiel School of Marine and Atmospheric Science, University of Miami, Miami, FL 33149, USA
    Science 287:857-9. 2000
    ..The alternative process of larval retention near local populations is shown to exist and may be of great importance in the maintenance of marine population structure and management of coastal marine resources...
  36. ncbi The ontogeny of immunity in the honey bee, Apis mellifera L. following an immune challenge
    Alice M Laughton
    Department of Animal and Plant Sciences, University of Sheffield, Sheffield S10 2TN, UK
    J Insect Physiol 57:1023-32. 2011
    ..Both castes showed signs of senescence in immune investment in the AMP response. Different sexes and life stages therefore alter their immune system management based on the combined factors of disease risk and life history...
  37. ncbi Improved stability of Drosophila larval neuromuscular preparations in haemolymph-like physiological solutions
    B A Stewart
    Department of Physiology, University of Toronto, Ontario, Canada
    J Comp Physiol A 175:179-91. 1994
    ..Thus, haemolymph-like solutions allow for prolonged, stable recording of synaptic transmission...
  38. ncbi Royalactin induces queen differentiation in honeybees
    Masaki Kamakura
    Biotechnology Research Center, Toyama Prefectural University, Imizu, Toyama 939 0398, Japan
    Nature 473:478-83. 2011
    ..These findings indicate that a specific factor in royal jelly, royalactin, drives queen development through an Egfr-mediated signalling pathway...
  39. ncbi Pyrosequencing the Manduca sexta larval midgut transcriptome: messages for digestion, detoxification and defence
    Y Pauchet
    School of Biosciences, University of Exeter, Cornwall Campus, Penryn, UK
    Insect Mol Biol 19:61-75. 2010
    ..Similar studies of other tissues will allow for a tissue by tissue description of the M. sexta transcriptome and will form an essential complimentary step on the road to genome sequencing and annotation...
  40. ncbi Coral reef fish larvae settle close to home
    Geoffrey P Jones
    Centre for Coral Reef Biodiversity, School of Marine Biology and Aquaculture, James Cook University, Townsville, Qld 4811, Australia
    Curr Biol 15:1314-8. 2005
    ..The degree of local retention indicates that marine reserves can provide recruitment benefits not only beyond but also within their boundaries...
  41. ncbi painless, a Drosophila gene essential for nociception
    W Daniel Tracey
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Cell 113:261-73. 2003
    ..An antibody to Painless binds to localized dendritic structures that we hypothesize are involved in nociceptive signaling...
  42. ncbi Anaplastic lymphoma kinase spares organ growth during nutrient restriction in Drosophila
    Louise Y Cheng
    Division of Developmental Neurobiology, Medical Research Council National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK
    Cell 146:435-47. 2011
    ..Together, these findings identify a brain-sparing mechanism that shares some regulatory features with the starvation-resistant growth programs of mammalian tumors...
  43. ncbi Insect odor and taste receptors
    Elissa A Hallem
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
    Annu Rev Entomol 51:113-35. 2006
    ..Here we discuss recent advances in our understanding of the molecular and cellular basis of odor and taste coding in insects...
  44. pmc Bacterial diversity analysis of larvae and adult midgut microflora using culture-dependent and culture-independent methods in lab-reared and field-collected Anopheles stephensi-an Asian malarial vector
    Asha Rani
    Insect Resistance Group, International Centre for Genetic Engineering and Biotechnology ICGEB, ICGEB Campus, Aruna Asaf Ali Marg, New Delhi, India
    BMC Microbiol 9:96. 2009
    ....
  45. ncbi A two-color acid-free cartilage and bone stain for zebrafish larvae
    M B Walker
    Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
    Biotech Histochem 82:23-8. 2007
    ..We have developed an acid-free method to stain cartilage and bone simultaneously in zebrafish larvae. This method has the additional advantage that PCR genotyping of stained specimens is possible...
  46. pmc Identifying the most productive breeding sites for malaria mosquitoes in The Gambia
    Ulrike Fillinger
    Disease Control and Vector Biology Unit, London School of Hygiene and Tropical Medicine, London, UK
    Malar J 8:62. 2009
    ..This study aimed to determine the characteristics of larval habitats most frequently and most densely populated by anopheline larvae and to estimate the numbers of adults produced in different habitats...
  47. pmc The molecular and cellular basis of olfactory-driven behavior in Anopheles gambiae larvae
    Yuanfeng Xia
    Department of Biological Sciences and Pharmacology, Center for Molecular Neuroscience, Institutes of Chemical Biology and Global Health and Program in Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37235, USA
    Proc Natl Acad Sci U S A 105:6433-8. 2008
    ..These advances may ultimately enhance the development of vector control strategies, targeting olfactory pathways in larval-stage mosquitoes to reduce the catastrophic effects of malaria and other diseases...
  48. ncbi Chitosan/double-stranded RNA nanoparticle-mediated RNA interference to silence chitin synthase genes through larval feeding in the African malaria mosquito (Anopheles gambiae)
    X Zhang
    Department of Entomology and Arthropod Genomics Center, Kansas State University, Manhattan, KS 66506, USA
    Insect Mol Biol 19:683-93. 2010
    ..These results suggest great potential for using such a nanoparticle-based RNAi technology for high-throughput screening of gene functions and for developing novel strategies for pest management...
  49. ncbi Functional imaging reveals rapid development of visual response properties in the zebrafish tectum
    Cristopher M Niell
    Neutosciences Program, Department of Molecular and Cell Physiology, Stanford University, Stanford, California 94305, USA
    Neuron 45:941-51. 2005
    ..Surprisingly, most of these properties are established soon after dendrite growth and synaptogenesis begin and do not require patterned visual experience or a protracted period of refinement...
  50. pmc Hemolymph sugar homeostasis and starvation-induced hyperactivity affected by genetic manipulations of the adipokinetic hormone-encoding gene in Drosophila melanogaster
    Gyunghee Lee
    Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, Tennessee 37996, USA
    Genetics 167:311-23. 2004
    ..the AKH neurons indicated that AKH has multiple target tissues as follows: the prothoracic gland and aorta in the larva and the crop and brain in the adult...
  51. ncbi Symbiotic bacteria protect wasp larvae from fungal infestation
    Martin Kaltenpoth
    Department of Animal Ecology and Tropical Biology and University of Würzburg, Am Hubland 97074 Würzburg, Germany
    Curr Biol 15:475-9. 2005
    ..The bacteria are taken up by the larva and occur on the walls of the cocoon...
  52. ncbi Contributions of Anopheles larval control to malaria suppression in tropical Africa: review of achievements and potential
    K Walker
    Department of Entomology, College of Agriculture and Life Sciences, University of Arizona, Tucson, Arizona 85721, USA
    Med Vet Entomol 21:2-21. 2007
    ..These approaches are especially suitable for urban areas, where larval habitats are limited, particularly when applied in conjunction with IRS and other adulticidal measures, such as the use of insecticide treated bednets...
  53. ncbi double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation
    J L Price
    Laboratory of Genetics and National Science Foundation Science and Technology Center for Biological Timing, The Rockefeller University, New York, New York 10021, USA
    Cell 94:83-95. 1998
    ..This would promote a delay between per/tim transcription and PER/TIM complex function, which is essential for molecular rhythmicity...
  54. pmc Pickpocket is a DEG/ENaC protein required for mechanical nociception in Drosophila larvae
    Lixian Zhong
    Pharmacology Science Training Program, Duke University Medical Center, Durham, NC 27710, USA
    Curr Biol 20:429-34. 2010
    Highly branched class IV multidendritic sensory neurons of the Drosophila larva function as polymodal nociceptors that are necessary for behavioral responses to noxious heat (>39 degrees C) or noxious mechanical (>30 mN) stimuli...
  55. ncbi Local replenishment of coral reef fish populations in a marine reserve
    Glenn R Almany
    Australian Research Council Centre of Excellence for Coral Reef Studies and School of Marine and Tropical Biology, James Cook University, Townsville QLD 4811, Australia
    Science 316:742-4. 2007
    ..If natal homing of larvae is a common life-history strategy, the appropriate spatial scales for the management and conservation of coral reefs are likely to be much smaller than previously assumed...
  56. ncbi Synaptic development: insights from Drosophila
    Catherine A Collins
    Department of Molecular Biology and Pharmacology, Campus Box 8103, 660 South Euclid, Washington University School of Medicine, St Louis, MO 63110, USA
    Curr Opin Neurobiol 17:35-42. 2007
    ....
  57. ncbi Visualization of cranial motor neurons in live transgenic zebrafish expressing green fluorescent protein under the control of the islet-1 promoter/enhancer
    S Higashijima
    Inheritance and Variation Group, Precursory Research for Embryonic Science and Technology, Japan Science and Technology Corporation, Honmachi, Kawaguchi, Saitama 332 0012, Japan
    J Neurosci 20:206-18. 2000
    ..This finding suggests that the trigeminal motor neurons in the two clusters adopt distinct fates. In future experiments, this transgenic line of zebrafish will allow for a genetic analysis of cranial motor neuron development...
  58. ncbi Zebrafish pigmentation mutations and the processes of neural crest development
    R N Kelsh
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Genetik, Tubingen, Germany
    Development 123:369-89. 1996
    ..In combination with the embryological advantages of zebrafish, these mutations should permit cellular and molecular dissection of many aspects of neural crest development...
  59. pmc Strain- and genotype-specific differences in virulence of Paenibacillus larvae subsp. larvae, a bacterial pathogen causing American foulbrood disease in honeybees
    Elke Genersch
    Institute for Bee Research, Friedrich Engels Str 32, 16540 Hohen Neuendorf, Germany
    Appl Environ Microbiol 71:7551-5. 2005
    ..One genotype killed rather quickly, with a mean LT100 of 7.8 +/- 1.7 days postinfection, while the other genotypes acted more slowly, with mean LT100s of 11.2 +/- 0.8 and 11.6 +/- 0.6 days postinfection...
  60. pmc Regulation and function of Arabidopsis JASMONATE ZIM-domain genes in response to wounding and herbivory
    Hoo Sun Chung
    Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, MI 48824, USA
    Plant Physiol 146:952-64. 2008
    ..Our results also indicate that the timing of JA-induced transcription in response to wounding is more rapid than previously realized...
  61. ncbi Trehalose renders the dauer larva of Caenorhabditis elegans resistant to extreme desiccation
    Cihan Erkut
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden 01307, Germany
    Curr Biol 21:1331-6. 2011
    ..We show that the C. elegans dauer larva is a true anhydrobiote: under defined conditions it can survive even after losing 98% of its body water...
  62. pmc Characterization of Drosophila larval crawling at the level of organism, segment, and somatic body wall musculature
    Ellie S Heckscher
    Institute of Neuroscience, Howard Hughes Medical Institute, University of Oregon, Eugene, Oregon 97403, USA
    J Neurosci 32:12460-71. 2012
    ..This work lays a foundation for use of Drosophila larva as a model system for studying the genetics and development of rhythmic behavior.
  63. ncbi Ectopic and increased expression of Fasciclin II alters motoneuron growth cone guidance
    D M Lin
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Neuron 13:507-23. 1994
    ..These phenotypes show that changes in the pattern and level of Fas II expression can alter growth cone guidance, apparently in part by modulating the ability of these growth cones to respond to other guidance cues...
  64. pmc Census of the bacterial community of the gypsy moth larval midgut by using culturing and culture-independent methods
    Nichole A Broderick
    Department of Entomology, University of Wisconsin, Madison, Wisconsin 53706, USA
    Appl Environ Microbiol 70:293-300. 2004
    ..These results provide the first comprehensive description of the microbial diversity of a lepidopteran midgut and demonstrate that the plant species in the diet influences the composition of the gut bacterial community...
  65. pmc Late-acting dominant lethal genetic systems and mosquito control
    Hoang Kim Phuc
    Department of Zoology, University of Oxford, South Parks Road, Oxford, UK
    BMC Biol 5:11. 2007
    ..Additionally, vector populations with strong density-dependent effects will tend to be resistant to SIT-based control as the population-reducing effect of induced sterility will tend to be offset by reduced density-dependent mortality...
  66. pmc Larval habitat segregation between the molecular forms of the mosquito Anopheles gambiae in a rice field area of Burkina Faso, West Africa
    G Gimonneau
    Maladies Infectieuses et Vecteurs Ecologie, Genetique, Evolution et Contrôle, UMR224, Institut de Recherche pour le Developpement, 911 Avenue Agropolis, Montpellier, France
    Med Vet Entomol 26:9-17. 2012
    ..Segregation appears to be clearly linked to anthropogenic permanent habitats and the community structure they support...
  67. ncbi Effects of different temperature regimens on the development of Aedes aegypti (L.) (Diptera: Culicidae) mosquitoes
    Azad Mohammed
    Department of Life Sciences, The University of the West Indies, St Augustine, Trinidad and Tobago
    Acta Trop 119:38-43. 2011
    ..Using these key factors control strategies are recommended to manage vector populations as expected increases in temperatures impact the Caribbean region...
  68. ncbi Effect of temperature and inter-specific competition on the development and survival of Anopheles gambiae sensu stricto and An. arabiensis larvae
    Matthew J Kirby
    School of Biological and Biomedical Sciences, Durham University, Science Laboratories, UK
    Acta Trop 109:118-23. 2009
    ..The development time from first instar larva to adult at constant water temperatures (25, 30 and 35 degrees C) was measured in these two species when reared ..
  69. pmc Deep brain photoreceptors control light-seeking behavior in zebrafish larvae
    António M Fernandes
    Developmental Biology Unit, Faculty of Biology, BIOSS Centre for Biological Signalling Studies and FRIAS Freiburg Institute for Advanced Studies, University of Freiburg, 79104 Freiburg, Germany
    Curr Biol 22:2042-7. 2012
    ..Our findings shed light on the identity and function of deep brain photoreceptors and suggest that otpa specifies an ancient population of sensory neurons that mediate behavioral responses to light...
  70. ncbi Thyroid hormones in growth and development of fish
    D M Power
    Centro de Ciencias do Mar, Universidade do Algarve, Campus de Gambelas, 8000 117 Faro, Portugal
    Comp Biochem Physiol C Toxicol Pharmacol 130:447-59. 2001
    ..The role of THs and TRs in fish embryogenesis, larval development and during metamorphosis will be discussed...
  71. ncbi Density-dependent development of Anopheles gambiae (Diptera: Culicidae) larvae in artificial habitats
    John E Gimnig
    Vector Biology and Control Research Centre, Kenya Medical Research Institute, Kisumu
    J Med Entomol 39:162-72. 2002
    ..020 d and female dry mass decreased by 0.74 microg with each additional larva. By fitting the data to the pupation window model, the estimated minimum dry mass to achieve pupation was 0...
  72. pmc Defining challenges and proposing solutions for control of the virus vector Aedes aegypti
    Amy C Morrison
    Department of Entomology, University of California, Davis, Davis, California, United States of America
    PLoS Med 5:e68. 2008
  73. ncbi Cross-induction of detoxification genes by environmental xenobiotics and insecticides in the mosquito Aedes aegypti: impact on larval tolerance to chemical insecticides
    Rodolphe Poupardin
    Laboratoire d Ecologie Alpine, UMR CNRS Université Joseph Fourier 5553, Equipe Perturbations Environnementales et Xénobiotiques, Domaine Universitaire de Saint Martin d Hères 2233, rue de la piscine Bât D Biologie, BP 53, 38041 Grenoble Cedex 9, France
    Insect Biochem Mol Biol 38:540-51. 2008
    ..Molecular mechanisms involved and impact on mosquito control strategies are discussed...
  74. pmc Differential alteration of two aminopeptidases N associated with resistance to Bacillus thuringiensis toxin Cry1Ac in cabbage looper
    Kasorn Tiewsiri
    Department of Entomology, Cornell University, New York State Agricultural Experiment Station, Geneva, NY 14456, USA
    Proc Natl Acad Sci U S A 108:14037-42. 2011
    ..Along with identifying reduced expression of APN1 as the molecular basis of Bt resistance selected in an agricultural setting, our findings demonstrate the importance of APN1 to the mode of action of Bt toxin Cry1Ac...
  75. ncbi Maize landraces recruit egg and larval parasitoids in response to egg deposition by a herbivore
    Amanuel Tamiru
    Habitat Management Programme, International Centre of Insect Physiology and Ecology, PO Box 30, Mbita Point, Kenya
    Ecol Lett 14:1075-83. 2011
    ..Our findings suggest that indirect plant defence traits may have become lost during crop breeding and could be valuable in new resistance breeding for sustainable agriculture...
  76. ncbi Anopheles gambiae s.s. breeding in polluted water bodies in urban Lagos, southwestern Nigeria
    T S Awolola
    Public Health Division, Nigerian Institute of Medical Research, Yaba, Lagos, Nigeria
    J Vector Borne Dis 44:241-4. 2007
    ..Urban malaria is on the rise in Nigeria due to rapid industrialisation and developmental activities. A study was undertaken in Lagos, Nigeria to study the Anopheles breeding in polluted water bodies...
  77. ncbi Characteristics of larval anopheline (Diptera: Culicidae) habitats in Western Kenya
    J E Gimnig
    Kenya Medical Research Institute, Centre for Vector Biology and Control Research, Kisumu
    J Med Entomol 38:282-8. 2001
    ..Together, these results indicate that An. gambiae and An. arabiensis have similar requirements for the larval environment and that, at least in western Kenya, they do not segregate into separate habitats...
  78. pmc Unexpected high losses of Anopheles gambiae larvae due to rainfall
    Krijn P Paaijmans
    Meteorology and Air Quality, Wageningen University, Wageningen, The Netherlands
    PLoS ONE 2:e1146. 2007
    ..Here we study the impact of rainfall, one of the abiotic factors to which the immatures are frequently exposed, on their mortality...
  79. ncbi Spatiotemporal gene expression targeting with the TARGET and gene-switch systems in Drosophila
    Sean E McGuire
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Sci STKE 2004:pl6. 2004
    ..In this protocol, we provide guidelines for the use of these two novel systems, which should have general utility in studying Drosophila biology and in using the fly as a model for human disease...
  80. pmc Development of vegetable farming: a cause of the emergence of insecticide resistance in populations of Anopheles gambiae in urban areas of Benin
    Anges William M Yadouleton
    Centre de Recherche Entomologique de Cotonou, Benin
    Malar J 8:103. 2009
    ..This study aims to assess the rapid expansion of urban agriculture especially, its contribution to the emergence of insecticide resistance in populations of Anopheles gambiae...
  81. pmc The odorant binding protein gene family from the genome of silkworm, Bombyx mori
    Da Ping Gong
    The Key Sericultural Laboratory of Agricultural Ministry, Southwest University, Chongqing, PR China
    BMC Genomics 10:332. 2009
    ..Insect chemoreception is mediated by two large and diverse gene superfamilies, chemoreceptors and odorant binding proteins (OBPs). OBPs are believed to transport hydrophobic odorants from the environment to the olfactory receptors...
  82. pmc Structure and topology of microbial communities in the major gut compartments of Melolontha melolontha larvae (Coleoptera: Scarabaeidae)
    Markus Egert
    Max Planck Institute for Terrestrial Microbiology, Karl von Frisch Strasse, 35043 Marburg, Germany
    Appl Environ Microbiol 71:4556-66. 2005
    ..and the composition and topology of the intestinal microbiota in the major gut compartments of the root-feeding larva of the European cockchafer (Melolontha melolontha) were studied...
  83. ncbi The biology of coral metamorphosis: molecular responses of larvae to inducers of settlement and metamorphosis
    L C Grasso
    Centre for the Molecular Genetics of Development, Molecular Genetics and Evolution Group, Research School of Biological Sciences, Australian National University, P O Box 475, Canberra, ACT, 2612, Australia
    Dev Biol 353:411-9. 2011
    Like many other cnidarians, corals undergo metamorphosis from a motile planula larva to a sedentary polyp...
  84. ncbi A hormonal signaling pathway influencing C. elegans metabolism, reproductive development, and life span
    B Gerisch
    Max Planck Institut fur Molekulare Genetik, Ihnestr 73, D 14195 Berlin, Germany
    Dev Cell 1:841-51. 2001
    ..Sensory neurons, hypodermis, and somatic gonadal cells expressing daf-9 identify potential endocrine tissues. Evidently, lipophilic hormones influence nematode metabolism, diapause, and life span...
  85. ncbi Recruitment of entomopathogenic nematodes by insect-damaged maize roots
    Sergio Rasmann
    University of Neuchatel, Institute of Zoology, Laboratory of Animal Ecology and Entomology, CP 2, CH 2007 Neuchatel, Switzerland
    Nature 434:732-7. 2005
    ..Development of new varieties that release the attractant in adequate amounts should help enhance the efficacy of nematodes as biological control agents against root pests like D. v. virgifera...
  86. ncbi Insecticide resistance and its association with target-site mutations in natural populations of Anopheles gambiae from eastern Uganda
    Urvashi Ramphul
    Vector Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Trans R Soc Trop Med Hyg 103:1121-6. 2009
    ..Intriguingly, the association between DDT resistance and the presence of L1014S is consistent with a co-dominant effect, with heterozygous individuals showing an intermediate phenotype...
  87. ncbi Vesicular glutamate transporter 3 is required for synaptic transmission in zebrafish hair cells
    Nikolaus Obholzer
    Howard Hughes Medical Institute, Oregon Hearing Research Center and Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Neurosci 28:2110-8. 2008
    ..Lack of postsynaptic action currents in the mutants suggests that the remaining hair-cell synaptic vesicles contain insufficient levels of glutamate for generation of action potentials in first-order neurons...
  88. pmc Highly focused anopheline breeding sites and malaria transmission in Dakar
    Vanessa Machault
    Unité d entomologie médicale, Equipe 7 Maladies Emergentes et Moustiques, Institut de Medecine Tropicale du Service de Sante des Armees, Allée du Médecin Colonel Jamot, Parc du Pharo, 13262 Marseille cedex 07, France
    Malar J 8:138. 2009
    ....
  89. ncbi A chemical enterocolitis model in zebrafish larvae that is dependent on microbiota and responsive to pharmacological agents
    Stefan H Oehlers
    Department of Molecular Medicine and Pathology, School of Medical Sciences, The University of Auckland, Auckland, New Zealand
    Dev Dyn 240:288-98. 2011
    ..This system will be useful to rapidly interrogate in vivo the biological significance of the IBD candidate genes so far identified and to carry out pharmacological modifier screens...
  90. ncbi Specialized hepatocyte-like cells regulate Drosophila lipid metabolism
    Eugenio Gutierrez
    Medical Research Council, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Nature 445:275-80. 2007
    ..These findings provide evidence that some lipid-processing functions of the mammalian liver are performed in insects by oenocytes...
  91. pmc Nociceptive neurons protect Drosophila larvae from parasitoid wasps
    Richard Y Hwang
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Curr Biol 17:2105-16. 2007
    ..In response, the larvae "roll" with a motor pattern that is completely distinct from the style of locomotion that is used for foraging...
  92. pmc Prothoracicotropic hormone regulates developmental timing and body size in Drosophila
    Zofeyah McBrayer
    The Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Dev Cell 13:857-71. 2007
    ..These results indicate that final body size in insects is determined by a balance between growth-rate regulators such as insulin and developmental timing cues such as PTTH that set the duration of the feeding interval...
  93. pmc Active sampling and decision making in Drosophila chemotaxis
    Alex Gomez-Marin
    EMBL CRG Systems Biology Unit, Center for Genomic Regulation CRG and UPF, 08003 Barcelona, Spain
    Nat Commun 2:441. 2011
    ..Our findings suggest that larval chemotaxis represents an intermediate navigation strategy between the biased random walks of Escherichia Coli and the stereo-olfaction observed in rats and humans...
  94. ncbi The insect neuropeptide PTTH activates receptor tyrosine kinase torso to initiate metamorphosis
    Kim F Rewitz
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Science 326:1403-5. 2009
    ..We conclude that PTTH initiates metamorphosis by activation of the Torso/ERK pathway...
  95. pmc Predation efficiency of Anopheles gambiae larvae by aquatic predators in western Kenya highlands
    Eliningaya J Kweka
    Centre for Global Health Research, Kenya Medical Research Institute, P O Box 1578, Kisumu 40100, Kenya
    Parasit Vectors 4:128. 2011
    ..In the current study, we examined the predation efficiency of five predators on Anopheles gambiae s.s larvae in 24 hour and semi- field evaluations...
  96. ncbi Herbivory: caterpillar saliva beats plant defences
    Richard O Musser
    Department of Entomology, University of Arkansas, Fayetteville, Arkansas 72701, USA
    Nature 416:599-600. 2002
    ..We find that the enzyme glucose oxidase counteracts the production of nicotine induced by the caterpillar feeding on the plant...
  97. ncbi The Tribolium chitin synthase genes TcCHS1 and TcCHS2 are specialized for synthesis of epidermal cuticle and midgut peritrophic matrix
    Y Arakane
    USDA ARS Grain Marketing and Production Research Center, Manhattan, KS 66502, USA
    Insect Mol Biol 14:453-63. 2005
    ..However, RNAi-mediated down-regulation of TcCHS2, but not TcCHS1, led to cessation of feeding, a dramatic shrinkage in larval size and reduced chitin content in the midgut...
  98. ncbi Swimming of larval zebrafish: ontogeny of body waves and implications for locomotory development
    Ulrike K Müller
    Wageningen University, Experimental Zoology Group, Marijkeweg 40, 6709 PG Wageningen, The Netherlands
    J Exp Biol 207:853-68. 2004
    ..2) and strain rates (up to 30 s(-1) in white muscle fibres) yet are able to power swimming for several seconds...
  99. ncbi Enhanced locomotion caused by loss of the Drosophila DEG/ENaC protein Pickpocket1
    Joshua A Ainsley
    Department of Physiology and Biophysics, University of Iowa, Roy J and Lucille A Carver College of Medicine, Iowa City, IA 52242, USA
    Curr Biol 13:1557-63. 2003
    ....
  100. ncbi RNA interference-mediated knockdown of a cytochrome P450, CYP6BG1, from the diamondback moth, Plutella xylostella, reduces larval resistance to permethrin
    Ma Anita M Bautista
    Laboratory of Applied Entomology, Graduate School of Bioagricultural Sciences, Nagoya University, Furo cho, Chikusa ku, Nagoya, Japan
    Insect Biochem Mol Biol 39:38-46. 2009
    ..xylostella strain did not lead to changes in the level of resistance to permethrin, supporting further the specific involvement of CYP6BG1 in the resistance...
  101. ncbi bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila
    Julius Brennecke
    European Molecular Biology Laboratory, Meyerhofstr 1, 69117 Heidelberg, Germany
    Cell 113:25-36. 2003
    ..bantam microRNA simultaneously stimulates cell proliferation and prevents apoptosis. We identify the pro-apoptotic gene hid as a target for regulation by bantam miRNA, providing an explanation for bantam's anti-apoptotic activity...

Research Grants76

  1. HEAT SHOCK PROTEIN GP96 AND IMMUNITY
    Nicholas Cohen; Fiscal Year: 2003
    ..Experiments to evaluate the specificity and peptide complex-dependency of these putative alloimmune reactivities are presented as are experiments to reveal the nature of effector cells involved. ..
  2. Phosphotyrosine signaling pathways controlling tracheal tube geometry
    KAI G ZINN; Fiscal Year: 2013
    ..The respiratory (tracheal) system of the Drosophila larva has provided a useful genetic model for the study of the development of complex branched tubular networks...
  3. A XENOPUS LAEVIS RESEARCH RESOURCE FOR IMMUNOBIOLOGY
    Jacques Robert; Fiscal Year: 2013
    ..We are proposing to continue the maintenance and the development of this unique non-mammalian resource facility for biomedical research for the benefit of the whole scientific community. ..
  4. Experimental Molecular Vaccines for Schistosomiasis
    Afzal A Siddiqui; Fiscal Year: 2012
    ..Such a vaccine would greatly reduce the need for logistically difficult and expensive drug-based programs and will save millions of lives. ..
  5. Genetic Analysis of Mosquito Metamorphosis
    James T Nishiura; Fiscal Year: 2012
    ..We propose to test, by knockdown of gene expression, the hypothesis that the genes broad and methoprene tolerant are central to mosquito development, and are in the pathway by which some insecticides block mosquito development. ..
  6. Thyroid hormone-dependent DNA methylation in the developing brain
    Yasuhiro Kyono; Fiscal Year: 2012
    ..Such understanding can contribute to the prevention, diagnosis and treatment of human neurological conditions such as mental retardation, autism spectrum disorder and schizophrenia. ..
  7. Using Drosophila as a model to understand TDP-43 function in ALS
    David B Morton; Fiscal Year: 2012
    ....
  8. The development of a recombinant vaccine against human onchocerciasis
    Sara Lustigman; Fiscal Year: 2013
    ..abstract_text> ..
  9. Tsetse Fecundity Reduction for Trypanosomiasis Control
    Serap Aksoy; Fiscal Year: 2013
    ..an unusual reproductive biology as they only develop one offspring at a time and give birth to a fully developed larva. Reproduction in tsetse is also unique in that it requires the presence of obligate mutualist symbiotic bacteria...
  10. Lipid metabolism during tsetse reproduction
    JOSH B BENOIT; Fiscal Year: 2013
    ..Currently, there is little information on tsetse reproduction, particularly how nutrients are mobilized to the larva. Since this aspect is unique in tsetse, control techniques blocking maternal nutrients could be tsetse specific...
  11. Genes required for lipid processing and digestive organ function in larval zebraf
    Steven A Farber; Fiscal Year: 2011
    ..The optically clear 6-day old zebrafish larva is ideally suited to address these gaps in our understanding of vertebrate intestinal lipid absorption and ..
  12. Hypocretin and Locus Ceruleus Interactions in Zebrafish Development and Behavior
    Grigorios Oikonomou; Fiscal Year: 2012
    ..This proposal aims to investigate the physical connections between these two centers, how these connections are formed during development and how these systems interact with each other to regulate sleep/wake behaviors. ! ..
  13. Molecular genetic control of the immature female mosquito vector
    Helen Benes; Fiscal Year: 2012
    ....
  14. Nuclear mechanics and mechanotransduction in muscular laminopathies
    Jan Lammerding; Fiscal Year: 2013
    ....
  15. Genetics of Alcohol Sensitivity in Drosophila
    Trudy F Mackay; Fiscal Year: 2013
    ....
  16. Targeted screening for Taenia solium tapeworms
    SETH E O'NEAL; Fiscal Year: 2011
    ..This proposal examines targeted screening for pork tapeworm carriers as a potentially effective, affordable and sustainable control strategy. ..
  17. Regulation of variable lifespan in castes of ants
    Hua Yan; Fiscal Year: 2013
    ..This study will provide novel insights into the regulatory mechanisms underlying longevity. ..
  18. MOLECULAR CHARACTERIZATION OF THE DORSAL MORPHOGEN
    Michael S Levine; Fiscal Year: 2013
    ..And finally, we will use quantitative imaging methods to attempt to visualize long-range enhancer-promoter interactions in the Drosophila embryo. ..
  19. Parallel en-face optical coherence microscopy with adaptive focus
    Guoqiang Li; Fiscal Year: 2012
    ..This would demonstrate potential application in colon cancer screening and oral cancer screening. For eye imaging, such a system can be used for diagnosis of the ocular surface diseases. ..
  20. Parallel en-face optical coherence microscopy with adaptive focus
    Guoqiang Li; Fiscal Year: 2011
    ..This would demonstrate potential application in colon cancer screening and oral cancer screening. For eye imaging, such a system can be used for diagnosis of the ocular surface diseases. ..
  21. Automated Analysis of Learning and Memory for Neuro-Developmental Studies
    Michael Levin; Fiscal Year: 2010
    ..The system consists of 200 individual chambers each containing a single Xenopus larva (or indeed, any of a number of small model species)...
  22. Targeted Manipulation of the Zebrafish Genome through Homologous Recombination
    Brian Ciruna; Fiscal Year: 2010
    ....
  23. Pharmacological Diversity of nAChRs in Clade III Nematodes: Levamisole receptors
    RICHARD JOHN MARTIN; Fiscal Year: 2013
    ..malayi preparation for studying ion-channel targets for future drug development; development or informed use of combinations (e.g. derquantel with avermectins;or combinations of subtype selective cholinergic anthelmintics). ..
  24. The Role of Phosphorylation in Photoreceptor Cell Biology
    ELLEN RUTH WEISS; Fiscal Year: 2010
    ..It is anticipated that these studies will lead to a better understanding of cone function advance our ability to prevent cone-related diseases. ..
  25. Ecological triggers to exploit antibiotic and virulence factor regulation
    JASON MICHAEL CRAWFORD; Fiscal Year: 2013
    ..circulatory system, it regurgitates the bacteria, which then produce an assortment of toxins that kill the larva, small molecules that signal for the IJ worms to become reproducing adults, small molecules that counter insect ..
  26. IMMUNOBIOLOGY OF SCHISTOSOME-MOLLUSC INTERACTIONS
    Timothy P Yoshino; Fiscal Year: 2013
    ..Therefore, knowledge gained from the proposed studies could very well lead to the development of more effective and novel methods for controlling human schistosome transmission by disrupting parasite development within the snail host. ..
  27. CONTROL OF NEURONAL ORGANELLE TRANSPORT
    Peter J Hollenbeck; Fiscal Year: 2013
    ....
  28. The switch between epigenetically silenced and active chromatin states
    Vincenzo Pirrotta; Fiscal Year: 2013
    ..Inappropriate targeting of human Trithorax produces mixed lineage leukemias. This project will study how TRX and ASH1 complexes are targeted to maintain the active state of their target genes. ..
  29. Synaptic target selection in Drosophila
    KAI G ZINN; Fiscal Year: 2013
    ..Knowledge about wiring mechanisms may help researchers to understand diseases in which neuronal connectivity patterns are altered. These include schizophrenia and autism. ..
  30. Structure-function analysis of zebrafish encoded 3-OST enzyme for HSV-1 Entry
    Vaibhav Tiwari; Fiscal Year: 2011
    ..Apart from that, our aim is to identify novel peptides to inhibit HSV-1 entry and spread in embryo model of ZF. ..
  31. Aging and Regeneration in a basal chordate
    Anthony W De Tomaso; Fiscal Year: 2013
    ..Studying the aging process in this simpler, ancestral organism will provide opportunities and insights not available in other species. ..
  32. Quantitative optical imaging of cilia-driven fluid flow
    MICHAEL ANDREW CHOMA; Fiscal Year: 2013
    ....
  33. Magnetomotive optical coherence tomography for molecular imaging of the eye
    Jianhua Wang; Fiscal Year: 2010
    ..We propose to further develop and optimize a magnetomotive optical coherence tomography (MMOCT) with an ultra-high speed and ultra-high resolution for imaging magnetic particle coupled molecules in living mouse models. ..
  34. Genetic Analysis of Host Specificity in Schistosoma mansoni
    Tim J Anderson; Fiscal Year: 2013
    ....
  35. Control of Neural Organelle Transport
    PETER HOLLENBECK; Fiscal Year: 2009
    ..abstract_text> ..
  36. Role of C-type Lectin Receptors in Myeloid Plasticity in Neurocysticercosis
    Judy M Teale; Fiscal Year: 2013
    ..NCC) is a common neurological disease in developing countries and the United States caused by the larva stages of the parasite Taenia solium...
  37. Ecology of African Highland Malaria
    Guiyun Yan; Fiscal Year: 2012
    ..This project will reveal critical parameters needed for the development of malaria early warning system, and will develop novel and cost-effective vector control methods for reducing malaria incidence and preventing malaria epidemics. ..
  38. Suppression of tadpole limbs: a model for organ size regulation
    RICHARD ELINSON; Fiscal Year: 2009
    ..This suppression of tadpole limbs provides a novel context to investigate mechanisms that control size of organs. In addition, several of the candidates for size control are implicated in human cancers. ..
  39. Poly(ADP-ribose)Polymerase 1 Regulates Nucleolar Structure and Functions
    ERNEST KOJO BOAMAH; Fiscal Year: 2012
    ..This proposal will uncover a novel and exciting role for PARP1, which may have significant impact on cancer treatment regimens. ..
  40. Function and Regulation of PKA-mediated GRK Phosphorylation in Photoreceptors
    JARED DAVID CHRISPELL; Fiscal Year: 2013
    ..These studies will provide a foundation for understanding the novel role of phosphorylation by PKA on recovery and adaptation in vertebrate cones. ..
  41. Sensory control of oxygen-dependent taxis behavior
    WAYNE ARLON JOHNSON; Fiscal Year: 2010
    ..levels, the external openings of the larval tracheal system, the posterior spiracles, are the only part of the larva projected above the surface of the food to allow access to the atmosphere...
  42. TRPA1: a polymodal sensor for aversive stimuli
    Craig Montell; Fiscal Year: 2013
    ..The proposed studies ultimately could lead to the identification of a new generation of safer and more effective repellents to control insect-borne disease by identifying and characterizing molecular targets for such compounds. ..
  43. The cold-sensing circuit of Drosophila larvae
    ASHLEY JAMES VONNER; Fiscal Year: 2013
    ....
  44. Isolation, Identification and Characterization of a Toxin Causing Biliary Atresia
    Rebecca G Wells; Fiscal Year: 2013
    ..glomulifera toxins~ and 3. To identify and characterize damage pathways induced by D. glomulifera toxins in mammalian models. ..
  45. Molecular Mechanisms of Protochordate Allorecognition
    Anthony W De Tomaso; Fiscal Year: 2013
    ..Botryllus schlosseri is born a chordate tadpole larva and later metamorphoses to an invertebrate adult, and represents the evolutionary transition between invertebrates ..
  46. CRANIOFACIAL MORPHOGENESIS IN ZEBRAFISH
    Charles B Kimmel; Fiscal Year: 2013
    ..The highest priority is to find genes that function to expand upon the early skeletal scaffold that forms in the embryo. Analyses of the mutants recovered in this screen will reveal how the genes work. ..
  47. Identifying genes required for digestive physiology and lipid metabolism
    Steven A Farber; Fiscal Year: 2013
    ....
  48. Endocannabinoid signaling and aging
    MATTHEW SIMON GILL; Fiscal Year: 2013
    ..In worms endocannabinoids appear to have a role in reproductive development and formation of the dauer larva. As is the case in mammals, they also regulate feeding rates in both larvae and adults...
  49. Adult genome-wide phenotypic analysis of molecularly defined mutant genes
    Mary C Mullins; Fiscal Year: 2013
    ..Genes acting in organ function and development, bone and skeletal formation, and fertility are among the many juvenile and adult onset disease genes expected. ..
  50. Polycystin function in zebrafish (PA-06-158)
    Iain A Drummond; Fiscal Year: 2013
    ..If sucessful, our work will provide a direct link between Polycystins as signaling proteins and the control of extracellular matrix production that may be common to all ADPKD pathologies. ..
  51. Illuminating the process of rod outer segment morphogenesis
    Yoshikazu Imanishi; Fiscal Year: 2013
    ..Understanding the process and mechanism of outer segment morphogenesis could reveal novel pathways which involve the products of ciliopathy causative genes. ..
  52. Examining the neural circuit for an instinctive olfactory-induced behavior in lar
    Scott T Laughlin; Fiscal Year: 2013
    ....
  53. Environmental filters and medically important container mosquitoes
    Donald A Yee; Fiscal Year: 2011
    ....
  54. PHYSIOLOGY OF INSECT AMINO ACID TRANSPORT
    Dmitri Y Boudko; Fiscal Year: 2010
    ..The anticipated results of this work will fill major gaps in our understanding of essential amino acid absorption in vector mosquitoes and develop the rationales for targeting NAT-SLC6s in vector control applications. ..
  55. Exploring the Venom Repertoire of Parasitoids
    JOHN HAYNES WERREN; Fiscal Year: 2013
    ..The project combines genetic, proteomic, physiological and evolutionary approaches to explore function, diversity, and potential for drug discovery in the immense pool of parasitoid venom proteins. ..
  56. Multisensory Integration for Food Perception and Behavior in Drosophila
    Ping Shen; Fiscal Year: 2013
    ..The genetically tractable Drosophila larva offers a unique opportunity for behavioral and neurobiological studies of the integration of multiple sensory ..
  57. Integrating physiological and genetic mechanisms of body size regulation
    Viviane Callier; Fiscal Year: 2013
    ..in the synthesis and release of ecdysone, the hormone that coordinates the developmental events necessary for a larva to molt and metamorphose...
  58. Expression and evolution of chemoreceptor genes in the model organism Daphnia
    DINORA CAROLINA PENALVA ARANA; Fiscal Year: 2010
    ....
  59. Cocaine Degrading Enzymes From Pest Insects Of Coca Plants
    Howard H Gu; Fiscal Year: 2010
    ....
  60. Genomic Mechanisms of Chromosomal Rearrangements in Drosophila Pseudoobscura
    Stephen W Schaeffer; Fiscal Year: 2013
    ..Genes that show differential expression or protein variation may be manipulated in future experiments designed to understand the molecular genetic basis that underpins inversion evolution. ..
  61. Zebrafish models of vascular inflammation and atherosclerosis
    Yury Miller; Fiscal Year: 2013
    ....
  62. Reprogramming Cells to Enable Limb Regeneration
    JONATHAN M SLACK; Fiscal Year: 2012
    ..This is also characteristic of mammalian limbs. Once developed, the proposed method is therefore expected also to be capable of stimulating regeneration in mammalian limbs. ..
  63. Genetic Analysis of Inner Ear Development in Xenopus tropicalis
    Richard M Harland; Fiscal Year: 2013
    ..We combine molecular approaches with classical embryological transplantations to understand the cel autonomy of mutants, and the signaling and responding tissues that interact to produce the functioning ear. ..
  64. Mosquito Vector Control Using Bt Coupled to Seed Oil Bodies
    Mohd Amir Abdullah; Fiscal Year: 2009
    ....
  65. CRYOPRESERVATION OF DROSOPHILA MELANOGASTER EMBRYOS
    PETER STEPONKUS; Fiscal Year: 1993
    ....
  66. NEMATODE-INDUCED PULMONARY GRANULOMA FORMATION
    STEPHEN KAYES; Fiscal Year: 1991
    Granulomatous disease, a major cause of pulmonary dysfunction, is an integral component of visceral larva migrans (VLM) syndrome due to infection with Toxocara canis...
  67. Investigating the role of leptin in larval growth and limb development in Xenopus
    ERICA CRESPI; Fiscal Year: 2009
    ..This research will greatly increase our understanding of the function of leptin in early life stages, and provide essential insight into how environmental cues affect growth and development during the earliest stages of life. ..
  68. IMMUNOREGULATION OF GUT EPITHELIUM TO ESCAPE PARASITISM
    GILBERT CASTRO; Fiscal Year: 1991
    ..spiralis. Additionally, the project will lead to the development of models for the study of immunopathological and immunophysiological processes in mucosal tissues down to the subcellular level...
  69. PROTECTIVE IMMUNITY IN HUMANS AGAINST O VOLVULUS LARVAE
    Sara Lustigman; Fiscal Year: 2001
    ..These studies should, therefore, be instrumental in developing a vaccine against onchocerciasis with anticipated clinical application. ..
  70. OXYGEN RADICAL-ENZYME SCAVENGING IN ONCHOCERCA
    Eric James; Fiscal Year: 1990
    ..The long-term objective of this study is to determine the feasibility and likely effectiveness of a putative therapeutic/transmission-blocking vaccine which employs worm oxygen radical scavenging enzymes as antigens...
  71. The role of cannabinoid signaling in the nematode Caenorhabditis elegans
    MATTHEW SIMON GILL; Fiscal Year: 2010
    ..pathway acts during development to regulate the decision to proceed with reproductive growth or form the dauer larva, an alternate larval stage that allows the worm to survive periods of population overcrowding and starvation...
  72. MOLECULAR PHYSIOLOGY OF THE EPITRACHEAL ENDOCRINE SYSTEM
    Michael Adams; Fiscal Year: 2001
    Insect development from larva to adult depends on the repeated shedding of old cuticle via a highly stereotyped behavior called ecdysis...
  73. EXPRESSION OF TMOF IN CHLORELLA/YEAST MOSQUITO LARVICIDE
    Dov Borovsky; Fiscal Year: 2001
    ..By the end of the phase II STTR we will have a commercial product that could be used in the USA and worldwide to control mosquito larvae. ..
  74. A feasibility study of genetically encoded fluorescent gold nanoclusters
    Jan Liphardt; Fiscal Year: 2009
    ..To ensure public health significance, much of the research will involve zebrafish, a vertebrate animal model system for an increasing number of human diseases. ..
  75. THYROID HORMONE RECEPTORS IN DEVELOPMENT
    VALERIE GALTON; Fiscal Year: 1999
    ..Thr proposed studies will utilize an eminently suitable animal model to investigate these important biological processes. ..
  76. Signaling Mechanisms in Drosophila Neural Development
    Kai Zinn; Fiscal Year: 2007
    ..We will also search for enhancers and suppressors of a bchs GOF eye phenotype. Candidate genes from the eye screen will be tested for modification of the bchs GOF neuromuscular phenotype and for interaction with bchs LOF mutations. ..