Genomes and Genes
map kinase signaling system
Summary: An intracellular signaling system involving the MAP kinase cascades (three-membered protein kinase cascades). Various upstream activators, which act in response to extracellular stimuli, trigger the cascades by activating the first member of a cascade, MAP KINASE KINASE KINASES; (MAPKKKs). Activated MAPKKKs phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES which in turn phosphorylate the MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). The MAPKs then act on various downstream targets to affect gene expression. In mammals, there are several distinct MAP kinase pathways including the ERK (extracellular signal-regulated kinase) pathway, the SAPK/JNK (stress-activated protein kinase/c-jun kinase) pathway, and the p38 kinase pathway. There is some sharing of components among the pathways depending on which stimulus originates activation of the cascade.
Publications293 found, 100 shown here
- Mammalian MAP kinase signalling cascadesL Chang
Department of Pharmacology, University of California San Diego, La Jolla 92093-0636, USA
Nature 410:37-40. 2001....
- Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammationJ M Kyriakis
Diabetes Research Laboratory, Medical Services, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
Physiol Rev 81:807-69. 2001..The nuclear factor-kappa B pathway, a second stress signaling paradigm, has been the subject of several excellent recent reviews (258, 260)...
- Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functionsG Pearson
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Endocr Rev 22:153-83. 2001..This review discusses the regulation and functions of mammalian MAP kinases. Nonenzymatic mechanisms that impact MAP kinase functions and findings from gene disruption studies are highlighted. Particular emphasis is on ERK1/2...
- MAP kinase signalling cascade in Arabidopsis innate immunityTsuneaki Asai
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114, USA
Nature 415:977-83. 2002..Activation of this MAPK cascade confers resistance to both bacterial and fungal pathogens, suggesting that signalling events initiated by diverse pathogens converge into a conserved MAPK cascade...
- Mutations of the BRAF gene in human cancerHelen Davies
Cancer Genome Project, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SA, UK
Nature 417:949-54. 2002..As BRAF is a serine/threonine kinase that is commonly activated by somatic point mutation in human cancer, it may provide new therapeutic opportunities in malignant melanoma...
- Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancerP J Roberts
Division of Pharmacotherapy and Experimental Therapeutics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7295, USA
Oncogene 26:3291-310. 2007..In this review, we summarize the current status of the different approaches and targets that are under evaluation and development for the therapeutic intervention of this key signaling pathway in human disease...
- Signal integration by JNK and p38 MAPK pathways in cancer developmentErwin F Wagner
Centro Nacional de Investigaciones Oncologicas, C Melchor Fernandez Almagro 3, Madrid 28029, Spain
Nat Rev Cancer 9:537-49. 2009..In this Review we highlight the recent progress made in defining the functions of the JNK and p38 MAPK pathways in different cancers...
- Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinasesGary L Johnson
Department of Pharmacology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Science 298:1911-2. 2002..The p38 MAPKs are activated by inflammatory cytokines and environmental stresses and may contribute to diseases like asthma and autoimmunity...
- COT drives resistance to RAF inhibition through MAP kinase pathway reactivationCory M Johannessen
Broad Institute of Harvard and Massachusetts Institute of Technology, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
Nature 468:968-72. 2010....
- Signal transduction by the JNK group of MAP kinasesR J Davis
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester 01605, USA
Cell 103:239-52. 2000
- Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancerArkaitz Carracedo
Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Harvard Medical School, Boston, Massachusetts, USA
J Clin Invest 118:3065-74. 2008....
- Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistanceJames A McCubrey
Department of Microbiology and Immunology, Leo Jenkins Cancer Center, Brody School of Medicine at East Carolina University, Greenville, NC 27858, USA
Biochim Biophys Acta 1773:1263-84. 2007....
- MAP kinase signalling pathways in cancerA S Dhillon
The Beatson Institute for Cancer Research, Bearsden, Glasgow, UK
Oncogene 26:3279-90. 2007..The balance and integration between these signals may widely vary in different tumours, but are important for the outcome and the sensitivity to drug therapy...
- Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAFPaul T C Wan
Section of Structural Biology, The Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK
Cell 116:855-67. 2004..The high activity mutants signal to ERK by directly phosphorylating MEK, whereas the impaired activity mutants stimulate MEK by activating endogenous C-RAF, possibly via an allosteric or transphosphorylation mechanism...
- Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancersJeffrey A Engelman
Nat Med 14:1351-6. 2008..These in vivo studies suggest that inhibitors of the PI3K-mTOR pathway may be active in cancers with PIK3CA mutations and, when combined with MEK inhibitors, may effectively treat KRAS mutated lung cancers...
- RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAFPoulikos I Poulikakos
Program in Molecular Pharmacology and Chemistry and Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
Nature 464:427-30. 2010..In agreement with this prediction, RAF inhibitors do not inhibit ERK signalling in cells that coexpress BRAF(V600E) and mutant RAS...
- Hyperactive Ras in developmental disorders and cancerSuzanne Schubbert
Department of Pediatrics, University of California, 513 Parnassus Avenue, Room HSE 302, San Francisco, California 94143, USA
Nat Rev Cancer 7:295-308. 2007..Here we will discuss the implications of germline mutations in the Ras-Raf-MEK-ERK pathway for understanding normal developmental processes and cancer pathogenesis...
- Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survivalMelissa R Junttila
Turku Centre for Biotechnology, University of Turku and Abo Akademi University, Turku, Finland
FASEB J 22:954-65. 2008..In addition, we will discuss the potential functional relevance of negative regulation of ERK pathway activity, for physiological and pathological conditions (e.g., cellular transformation)...
- MAPK signal pathways in the regulation of cell proliferation in mammalian cellsWei Zhang
The Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, College of Life Sciences, Beijing Normal University, China
Cell Res 12:9-18. 2002..The above effects are fulfilled by regulation of cell cycle engine and other cell proliferation related proteins. In this paper we discussed their functions and cooperation with other signal pathways in regulation of cell proliferation...
- Pathological roles of MAPK signaling pathways in human diseasesEun Kyung Kim
School of Life Sciences and Biotechnology, Korea University, Seoul 136 701, South Korea
Biochim Biophys Acta 1802:396-405. 2010..In this review, we summarize recent findings on the roles of MAPK signaling pathways in human disorders, focusing on cancer and neurodegenerative diseases including AD, PD, and ALS...
- Mitogen-activated protein kinase signaling in plantsMaria Cristina Suarez Rodriguez
Department of Biology, University of Copenhagen, Copenhagen, Denmark
Annu Rev Plant Biol 61:621-49. 2010..Future work needs to focus on identifying substrates of MAPKs, and on understanding how specificity is achieved among MAPK signaling pathways...
- Differential regulation and properties of MAPKsM Raman
Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, TX, USA
Oncogene 26:3100-12. 2007..Here, we describe some of the properties of the three major MAPK pathways and discuss how these properties govern pathway regulation and activity...
- Mitogen-activated protein kinases in apoptosis regulationTeiji Wada
IMBA Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr gasse3 5, Vienna A 1030, Austria
Oncogene 23:2838-49. 2004..In this review, we discuss MAPKs in apoptosis regulation with attention to mouse genetic models and critically point out the multiple roles of MAPKs...
- The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transitionS Meloche
Departments of Pharmacology and Molecular Biology, Institut de Recherche en Immunologie et Cancérologie, Universite de Montreal, Montreal, Quebec, Canada
Oncogene 26:3227-39. 2007..In this review, we discuss the mechanisms by which activated ERK1/ERK2 regulate growth and cell cycle progression of mammalian somatic cells. We also highlight the findings obtained from gene disruption studies...
- Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanismsA Bonni
Division of Neuroscience, Children s Hospital, and Department of Neurobiology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
Science 286:1358-62. 1999....
- FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitmentTilo Kunath
Centre Development in Stem Cell Biology, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
Development 134:2895-902. 2007....
- Targeting AKT/mTOR and ERK MAPK signaling inhibits hormone-refractory prostate cancer in a preclinical mouse modelCarolyn Waugh Kinkade
Department of Urology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
J Clin Invest 118:3051-64. 2008..We therefore propose that combination therapy targeting AKT/mTOR and ERK MAPK signaling pathways may be an effective treatment for patients with advanced prostate cancer, in particular those with hormone-refractory disease...
- Activation and signaling of the p38 MAP kinase pathwayTyler Zarubin
Department of Immunology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
Cell Res 15:11-8. 2005..Upstream and downstream components of p38 are described and questions remaining to be answered are posed. Finally, we propose several directions for future research on p38...
- Differential regulation of MAP kinase signalling by dual-specificity protein phosphatasesD M Owens
Cancer Research UK Stress Response Laboratory, Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
Oncogene 26:3203-13. 2007....
- Mitogen-activated protein kinase signaling in the heart: angels versus demons in a heart-breaking taleBeth A Rose
Departments of Anesthesiology, Physiology, and Medicine, David Geffen School of Medicine, Molecular Biology, Institute, University of California at Los Angeles, Los Angeles, CA 90095, USA
Physiol Rev 90:1507-46. 2010....
- FAK integrates growth-factor and integrin signals to promote cell migrationD J Sieg
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
Nat Cell Biol 2:249-56. 2000..Our results establish that FAK is an important receptor-proximal link between growth-factor-receptor and integrin signalling pathways...
- AP-1 as a regulator of cell life and deathEitan Shaulian
Department of Experimental Medicine and Cancer Research, School of Medicine, The Hebrew University, Jerusalem, 91120, Israel
Nat Cell Biol 4:E131-6. 2002..Mostly, c-Jun is a positive regulator of cell proliferation, whereas JunB has the converse effect. The intricate relationships between the different Jun proteins, their activities and the mechanisms that mediate them will be discussed...
- The MAP kinase signaling cascades: a system of hundreds of components regulates a diverse array of physiological functionsYonat Keshet
Department of Biological Regulation, The Weizmann Institute of Science, Rehovot, Israel
Methods Mol Biol 661:3-38. 2010..Mis-regulation of the MAPKs signals usually leads to diseases such as cancer and diabetes; therefore, studying the mechanisms of specificity-determination may lead to better understanding of these signaling-related diseases...
- The role of signaling pathways in the development and treatment of hepatocellular carcinomaS Whittaker
Dana Farber Cancer Institute, Boston, MA, USA
Oncogene 29:4989-5005. 2010..In addition, we also review the latest preclinical and clinical data on the rationally designed targeted agents that are now being directed against these pathways, with early evidence of success...
- A dp53/JNK-dependant feedback amplification loop is essential for the apoptotic response to stress in DrosophilaE Shlevkov
Centro de Biologia Molecular, Consejo Superior de Investigaciones Cientificas UAM, Madrid, Spain
Cell Death Differ 19:451-60. 2012..Thus, our results indicate that stress-induced apoptosis in Drosophila is dependant on an amplification loop mediated by dp53 and JNK. Furthermore, they also demonstrate a mechanism of mutual activation of proapoptotic genes...
- Suppression of Erk signalling promotes ground state pluripotency in the mouse embryoJennifer Nichols
Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
Development 136:3215-22. 2009..We propose that ES cells are not a tissue culture creation, but are essentially identical to pre-implantation epiblast cells...
- MAP kinase and painRu Rong Ji
Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, MRB 604, Boston, MA 02115, USA
Brain Res Rev 60:135-48. 2009..Although it is well documented that MAPK pathways can increase pain sensitivity via peripheral mechanisms, this review will focus on central mechanisms of MAPKs, especially ERK...
- p38 MAP-kinases pathway regulation, function and role in human diseasesAna Cuenda
MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
Biochim Biophys Acta 1773:1358-75. 2007..Here we focus on these emergent roles of p38MAPKs and their implication in different pathologies...
- Comparative genomics of MAP kinase and calcium-calcineurin signalling components in plant and human pathogenic fungiNicolas Rispail
Departamento de Genetica, Universidad de Cordoba, Cordoba, Spain
Fungal Genet Biol 46:287-98. 2009..cerevisiae signalling proteins, most likely reflect functional diversification or adaptation as filamentous fungi have evolved to occupy distinct ecological niches...
- Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fateSilvia D M Santos
European Molecular Biology Laboratory EMBL, Cell Biology and Biophysics, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
Nat Cell Biol 9:324-30. 2007..These results show that growth factor context determines the topology of the MAPK signalling network and that the resulting dynamics govern cell fate...
- The JNK signal transduction pathwayClaire R Weston
Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Curr Opin Cell Biol 19:142-9. 2007..Roles of novel molecules that participate in the JNK pathway have been defined and new insight into the role of JNK in survival signaling, cell death, cancer and diabetes has been achieved...
- Reactive oxygen species-induced activation of the MAP kinase signaling pathwaysJames A McCubrey
Department of Microbiology and Immunology, and the Leo W Jenkins Cancer Center, Brody School of Medicine at East Carolina University, Greenville, North Carolina 27834, USA
Antioxid Redox Signal 8:1775-89. 2006..The purpose of this review is to provide the reader with an overall understanding and appreciation of oxidative stress-induced MAPK signaling...
- Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitionsHector Peinado
Instituto de Investigaciones Biomédicas Alberto Sols CSIC UAM and Departamento de Bioquímica UAM, Arturo Duperier 4, 28029 Madrid, Spain
J Biol Chem 278:21113-23. 2003..These data support that MAPK and phosphatidylinositol 3-kinase signaling pathways are implicated in TGFbeta1-mediated induction of Snail promoter, probably through Ras activation and its downstream effectors...
- Dual control of nuclear EIN3 by bifurcate MAPK cascades in C2H4 signallingSang Dong Yoo
Department of Molecular Biology, Massachusetts General Hospital, Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114, USA
Nature 451:789-95. 2008..The results suggest a new paradigm for linking intertwined MAPK cascades to control quantitative responses and specificity in signalling networks...
- TAK1 is a ubiquitin-dependent kinase of MKK and IKKC Wang
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
Nature 412:346-51. 2001..We also provide evidence that TRAF6 is conjugated by the K63 polyubiquitin chains. These results indicate that ubiquitination has an important regulatory role in stress response pathways, including those of IKK and JNK...
- Stomatal development and patterning are regulated by environmentally responsive mitogen-activated protein kinases in ArabidopsisHuachun Wang
Division of Biological Sciences, University of Missouri, Columbia, Missouri 65211, USA
Plant Cell 19:63-73. 2007....
- Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: rationale and importance to inhibiting these pathways in human healthWilliam H Chappell
Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, USA
Oncotarget 2:135-64. 2011..Inhibitors targeting these pathways have many potential uses from suppression of cancer, proliferative diseases as well as aging...
- MAPK signalling pathways as molecular targets for anti-inflammatory therapy--from molecular mechanisms to therapeutic benefitsBozena Kaminska
Department of Cell Biology, Laboratory of Transcription Regulation, Nencki Institute of Experimental Biology, 3 Pasteur Str, 02 093 Warsaw, Poland
Biochim Biophys Acta 1754:253-62. 2005..Moreover, many of these drugs are small molecules that can be administered orally, and initial results of clinical trials have shown clinical benefits in patients with chronic inflammatory disease...
- Function and regulation in MAPK signaling pathways: lessons learned from the yeast Saccharomyces cerevisiaeRaymond E Chen
Division of Biochemistry and Molecular Biology, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3202, USA
Biochim Biophys Acta 1773:1311-40. 2007....
- MEKK1 is required for MPK4 activation and regulates tissue-specific and temperature-dependent cell death in ArabidopsisKazuya Ichimura
Sainsbury Laboratory, John Innes Centre, Colney Lane, Norwich NR4 7UH, United Kingdom
J Biol Chem 281:36969-76. 2006....
- A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunityDennis H Kim
Department of Genetics, Harvard Medical School, Boston, MA 02114, USA
Science 297:623-6. 2002..These data suggest that this MAP kinase signaling cassette represents an ancient feature of innate immune responses in evolutionarily diverse species...
- The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress responseHideki Inoue
Department of Molecular Biology, Graduate School of Science, Institute for Advanced Research, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
Genes Dev 19:2278-83. 2005..These results delineate the C. elegans p38 MAPK signaling pathway leading to the nucleus that responds to oxidative stress...
- Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanomaGideon Bollag
Plexxikon Inc, 91 Bolivar Drive, Berkeley, California 94710, USA
Nature 467:596-9. 2010..These data demonstrate that BRAF-mutant melanomas are highly dependent on B-RAF kinase activity...
- The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memoryJ D Sweatt
Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030 3498, USA
J Neurochem 76:1-10. 2001..Finally, I will speculate on what the critical downstream effectors of the erks are in neurons, and how they might provide a readout of the integrated signal...
- Rewired ERK-JNK signaling pathways in melanomaPablo Lopez-Bergami
Signal Transduction Program, The Burnham Institute for Medical Research, La Jolla, CA 92037, USA
Cancer Cell 11:447-60. 2007..Our data reveal that, in human melanoma, the rewired ERK signaling pathway upregulates JNK and activates the c-Jun oncogene and its downstream targets, including RACK1 and cyclin D1...
- Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascadesNick I Markevich
Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, 1020 Locust St, Philadelphia, PA 19107, USA
J Cell Biol 164:353-9. 2004..Hence, bistability induced by multisite covalent modification may be a widespread mechanism of the control of protein activity...
- Antitumor efficacy of the novel RAF inhibitor GDC-0879 is predicted by BRAFV600E mutational status and sustained extracellular signal-regulated kinase/mitogen-activated protein kinase pathway suppressionKlaus P Hoeflich
Department of Cancer Signaling and Translational Oncology, Genentech, Inc, South San Francisco, California 94080, USA
Cancer Res 69:3042-51. 2009..Taken together, these studies increase our understanding of the molecular determinants for antitumor efficacy resulting from RAF pathway inhibition and have implications for therapeutic intervention in the clinic...
- A systems-level analysis of perfect adaptation in yeast osmoregulationDale Muzzey
Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Cell 138:160-71. 2009..We conclude that the system contains only one effective integrating mechanism, which requires Hog1 kinase activity and regulates glycerol synthesis but not leakage...
- Scaffold number in yeast signaling system sets tradeoff between system output and dynamic rangeTy M Thomson
Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 108:20265-70. 2011..Additional analysis and experiment suggest that scaffold abundance sets a tradeoff between maximum system output and system dynamic range, a prediction supported by recent experiments...
- Tumour cell survival signalling by the ERK1/2 pathwayK Balmanno
Laboratory of Molecular Signalling, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK
Cell Death Differ 16:368-77. 2009....
- Serine phosphorylation of STATsT Decker
Vienna Biocenter, Institute of Microbiology and Genetics, Dr Bohr Gasse 9, A 1030 Vienna, Austria
Oncogene 19:2628-37. 2000..The biochemical and biological consequences of STAT serine phosphorylation are discussed. Oncogene (2000)...
- S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathwayMario Pende
Friedrich Miescher Institute for Biomedical Research, 4058 Basel, Switzerland
Mol Cell Biol 24:3112-24. 2004..These data reveal a redundancy between the S6K and the MAPK pathways in mediating early S6 phosphorylation in response to mitogens...
- Tunable signal processing in synthetic MAP kinase cascadesEllen C O'Shaughnessy
Howard Hughes Medical Institute, Department of Biomedical Engineering, Center for Advanced Biotechnology, Boston University, MA 02215, USA
Cell 144:119-31. 2011..This work demonstrates that tunable signal processing is inherent to minimal MAPK modules and elucidates principles for rational design of synthetic signaling systems...
- CD40-modulated dual-specificity phosphatases MAPK phosphatase (MKP)-1 and MKP-3 reciprocally regulate Leishmania major infectionNeetu Srivastava
National Centre for Cell Science, Ganeshkhind, Pune 411007, India
J Immunol 186:5863-72. 2011..The findings reveal a novel parasite-devised immune evasion strategy and an effective target to redirect CD40-regulated immune responses...
- Translational control by MAPK signaling in long-term synaptic plasticity and memoryRaymond J Kelleher
Howard Hughes Medical Institute, The Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Center for Cancer Research, Departments of Biology and Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA
Cell 116:467-79. 2004..These results suggest a crucial role for translational control by MAPK signaling in long-lasting forms of synaptic plasticity and memory...
- Specific bacterial suppressors of MAMP signaling upstream of MAPKKK in Arabidopsis innate immunityPing He
Department of Molecular Biology, Massachusetts General Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02114, USA
Cell 125:563-75. 2006..Deletions of avrPto and avrPtoB from pathogenic P. syringae reduce its virulence. The studies reveal a fundamental role of MAMP signaling in nonhost immunity, and a novel action of type III effectors from pathogenic bacteria...
- Dynamic control of yeast MAP kinase network by induced association and dissociation between the Ste50 scaffold and the Opy2 membrane anchorKatsuyoshi Yamamoto
Division of Molecular Cell Signaling, Institute of Medical Sciences, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
Mol Cell 40:87-98. 2010..Thus, dynamic regulation of Ste50-Opy2 interaction fine-tunes the MAPK signaling network...
- Input-output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic dataWilliam W Chen
Department of Systems Biology, Center for Cell Decision Processes, Harvard Medical School, Boston, MA 02115, USA
Mol Syst Biol 5:239. 2009..Thus, key system-wide features of ErbB signaling arise from nonlinear interaction among signaling elements, the properties of which appear quite different in context and in isolation...
- ERK1/2 phosphorylate Raptor to promote Ras-dependent activation of mTOR complex 1 (mTORC1)Audrey Carriere
Department of Pathology, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada
J Biol Chem 286:567-77. 2011..Our data provide a novel regulatory mechanism by which mitogenic and oncogenic activation of the Ras/MAPK pathway promotes mTOR signaling...
- Anchorage-dependent ERK signaling--mechanisms and consequencesAlan K Howe
University of North Carolina, Chapel Hill, School of Medicine, Department of Pharmacology, Campus Box 7365, Chapel Hill, North Carolina 27599 3765, USA
Curr Opin Genet Dev 12:30-5. 2002..Recent work has demonstrated that cell adhesion can regulate ERK signaling at several checkpoints and has begun to define the mechanism and consequences associated with anchorage-dependent effects on the ERK cascade...
- Phosphorylation of the human microRNA-generating complex mediates MAPK/Erk signalingZain Paroo
Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Cell 139:112-22. 2009..Taken together, these studies indicate that the MAPK/Erk pathway regulates the miRNA machinery and suggest a general principle, wherein signaling systems target the miRNA pathway to achieve biological responses...
- Integration of a phosphatase cascade with the mitogen-activated protein kinase pathway provides for a novel signal processing functionVirendra K Chaudhri
Immunology Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi 110067, India
J Biol Chem 285:1296-310. 2010..Thus, we identify an added dimension to signal processing wherein the output response to an external stimulus is additionally filtered through indicators that define the phenotypic status of the cell...
- Redox control of cell fate by MAP kinase: physiological roles of ASK1-MAP kinase pathway in stress signalingAtsushi Matsuzawa
Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113 0033, Japan
Biochim Biophys Acta 1780:1325-36. 2008..In this review, we focus on redox control of cell function by MAP kinase signaling, and provide the advanced mechanism of redox-regulated ASK1 activation and physiological roles of the ASK1-MAP kinase pathway in stress signaling...
- Tumor necrosis factor signalingH Wajant
Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring, Germany
Cell Death Differ 10:45-65. 2003..In particular, the multiple facets of crosstalk between the various signalling pathways engaged by TNF will be addressed...
- Reciprocal CD40 signals through p38MAPK and ERK-1/2 induce counteracting immune responsesRam Kumar Mathur
National Centre for Cell Science, Ganeshkhind, Pune 411007, India
Nat Med 10:540-4. 2004..These data uncover a new immune evasion strategy, whereby Leishmania differentially modulates CD40-engaged, reciprocally functioning signaling modules, and provide a new conceptual framework for immune homeostasis...
- Diphenyl difluoroketone: a curcumin derivative with potent in vivo anticancer activityDharmalingam Subramaniam
Section of Digestive Diseases and Nutrition, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73126, USA
Cancer Res 68:1962-9. 2008..Taken together, these data suggest that the novel curcumin-related compound EF24 is a potent antitumor agent that induces caspase-mediated apoptosis during mitosis and has significant therapeutic potential for gastrointestinal cancers...
- Reversing melanoma cross-resistance to BRAF and MEK inhibitors by co-targeting the AKT/mTOR pathwayMohammad Atefi
Department of Medicine, Division of Hematology Oncology, University of California Los Angeles, Los Angeles, California, United States of America
PLoS ONE 6:e28973. 2011..Clinical trials are in progress using MEK inhibitors following disease progression in patients receiving BRAF inhibitors. However, the PI3K/AKT pathway can also induce resistance to the inhibitors of MAPK pathway...
- MAP kinase pathwaysMaosong Qi
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
J Cell Sci 118:3569-72. 2005
- Protein phosphatases and the regulation of mitogen-activated protein kinase signallingS M Keyse
Molecular Pharmacology Unit, Imperial Cancer Research Fund, Biomedical Research Centre, Level 5, Ninewells Hospital, Dundee, DD1 9SY, UK
Curr Opin Cell Biol 12:186-92. 2000....
- Eiger, a TNF superfamily ligand that triggers the Drosophila JNK pathwayTatsushi Igaki
Laboratory for Cell Recovery Mechanisms, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
EMBO J 21:3009-18. 2002..We also show genetically that Eiger is a physiological ligand for the Drosophila JNK pathway. Our findings demonstrate that Eiger can initiate cell death through an IAP-sensitive cell death pathway via JNK signaling...
- Concomitant activation of the JAK/STAT, PI3K/AKT, and ERK signaling is involved in leptin-mediated promotion of invasion and migration of hepatocellular carcinoma cellsNeeraj K Saxena
Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Cancer Res 67:2497-507. 2007..Our findings have potential clinical implications for hepatocellular carcinoma progression in obese patients...
- Spatial and temporal patterns of ERK signaling during mouse embryogenesisLaura Beth Corson
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
Development 130:4527-37. 2003..These studies identify key domains of sustained ERK signaling in the intact mouse embryo, give significant insight into the regulation of this signaling in vivo and pinpoint regions where downstream target genes can be sought...
- Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transductionDavid Teis
Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
Dev Cell 3:803-14. 2002..Reduction of MP1 or p14 protein levels by siRNAi results in defective signal transduction. Therefore, our results suggest that the endosomal localization of the p14/MP1-MAPK scaffold complex is crucial for signal transduction...
- Ras signalling on the endoplasmic reticulum and the GolgiVi K Chiu
Department of Medicine, Cell Biology and Pharmacology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
Nat Cell Biol 4:343-50. 2002..Thus, Ras signalling is not limited to the PM, but also proceeds on the endomembrane...
- p38-Dependent marking of inflammatory genes for increased NF-kappa B recruitmentSimona Saccani
Institute for Research in Biomedicine, Via Vela 6, CH 6501, Bellinzona, Switzerland
Nat Immunol 3:69-75. 2002..These results show that p38 plays an additional role in the induction of the inflammatory and immune response: the regulation of NF-kappa B recruitment to selected chromatin targets...
- Mechanism of p38 MAP kinase activation in vivoDeborah Brancho
Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Genes Dev 17:1969-78. 2003..These data indicate that p38 MAPK is regulated by the coordinated and selective actions of three different protein kinases in response to cytokines and exposure to environmental stress...
- Cross-talk between ERK MAP kinase and Smad signaling pathways enhances TGF-beta-dependent responses in human mesangial cellsTomoko Hayashida
Department of Pediatrics, The Feinberg School of Medicine, Northwestern University, W 140, Pediatrics, 303 E Chicago Ave, Ward 12 112, Chicago, Illinois 60611 3008, USA
FASEB J 17:1576-8. 2003..These results indicate that ERK-dependent R-Smad linker region phosphorylation enhances collagen I synthesis and imply positive cross talk between the ERK and Smad pathways in human mesangial cells...
- Targeting the RAF-MEK-ERK pathway in cancer therapyClara Montagut
Medical Oncology Department and Cancer Research Program, Hospital del Mar IMIM, Passeig Maritim 25 29, 08003 Barcelona, Spain
Cancer Lett 283:125-34. 2009....
- The ups and downs of MEK kinase interactionsC Hagemann
Department of Cell Physiology and Pharmacology, University of Leicester, Medical Sciences Building, University Road, LE1 9HN, Leicester, UK
Cell Signal 13:863-75. 2001..This review summarises our current knowledge concerning the regulation and function of MEKK family members, with particular emphasis on those factors capable of directly interacting with distinct MEKK isoforms...
- Regulator of G protein signaling 5 protects against cardiac hypertrophy and fibrosis during biomechanical stress of pressure overloadHongliang Li
Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China
Proc Natl Acad Sci U S A 107:13818-23. 2010..These studies indicate that Rgs5 protein is a crucial component of the signaling pathway involved in cardiac remodeling and heart failure...
- MCL1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxolAaron M Domina
Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, NH 03755, USA
Oncogene 23:5301-15. 2004....
- Post-transcriptional regulation of gene expression by mitogen-activated protein kinase p38Andrew R Clark
Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, 1 Aspenlea Road, Hammersmith, London W6 8LH, UK
FEBS Lett 546:37-44. 2003..This review describes recent progress and remaining puzzles in the field of post-transcriptional regulation by p38...
- CD133+ HCC cancer stem cells confer chemoresistance by preferential expression of the Akt/PKB survival pathwayS Ma
Department of Pathology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China
Oncogene 27:1749-58. 2008..Targeting of this specific survival signaling pathway in CD133+ HCC CSCs may provide a novel therapeutic model for the disease...
- Mutant V599EB-Raf regulates growth and vascular development of malignant melanoma tumorsArati Sharma
Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey 17033, USA
Cancer Res 65:2412-21. 2005..Thus, these studies identify the mechanistic underpinnings by which mutant (V599E)B-RAF promotes melanoma development and show the effectiveness of targeting this protein to inhibit melanoma tumor growth...
- Participation of the p38 pathway in Drosophila host defense against pathogenic bacteria and fungiJianming Chen
Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China
Proc Natl Acad Sci U S A 107:20774-9. 2010..Together, our data demonstrate that the p38 pathway-mediated stress response contribute to Drosophila host defense against microbial infection...
- Role of mitogen-activated protein kinase kinase kinases in signal integrationB D Cuevas
Department of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7365, USA
Oncogene 26:3159-71. 2007..In this review, we describe how the MKKK 'hub' function regulates the specificity of MAPK activation, highlighting MKKKs as targets for therapeutic intervention in cancer and other diseases...
- A new paradigm for MAPK: structural interactions of hERK1 with mitochondria in HeLa cellsSoledad Galli
Laboratory of Cellular Dynamics, Max Planck Institute for Biophysical Chemistry, Gottingen, Germany
PLoS ONE 4:e7541. 2009..This work indicates for the first time the presence of diverse ERK-complexes in mitochondria and thus provides a new perspective for assessing the functions of ERK1 in the regulation of cellular signalling and trafficking in HeLa cells...
- Advances in the development of cancer therapeutics directed against the RAS-mitogen-activated protein kinase pathwayJudith S Sebolt-Leopold
Oncovera Therapeutics, Ann Arbor, Michigan 48103, USA
Clin Cancer Res 14:3651-6. 2008....
- Role of the phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways in the secretion of tumor necrosis factor-alpha and interleukin-10 by the PPD antigen of Mycobacterium tuberculosisSaet Byel Jung
Department of Microbiology, College of Medicine, Chungnam National University, Daejeon, South Korea
J Clin Immunol 25:482-90. 2005..Collectively, these data suggest that the PI 3-K and MAPK pathways play a central role in the regulation of both pro- and anti-inflammatory cytokines by the PPD antigen of M. tuberculosis...
- Mitotic aberration coupled with centrosome amplification is induced by hepatitis B virus X oncoprotein via the Ras-mitogen-activated protein/extracellular signal-regulated kinase-mitogen-activated protein pathwayChawon Yun
Department of Biochemistry and Molecular Biology, Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon, South Korea
Mol Cancer Res 2:159-69. 2004..These findings may provide a possible mechanism by which HBx promotes phenotypic progression by predisposing chromosomal alteration in HBV-infected liver...
- The unfolded protein response is induced by the cell wall integrity mitogen-activated protein kinase signaling cascade and is required for cell wall integrity in Saccharomyces cerevisiaeThomas Scrimale
Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Mol Biol Cell 20:164-75. 2009..We propose that the cellular responses to ER and cell wall stress are coordinated to buffer the cell against these two related cellular stresses...
- MECHANISMS OF HEMORRHAGE AND EDEMA IN TPA STROKE THERAPYENG LO; Fiscal Year: 2006..This proposal should fit the goals of the Stroke PRG because it examines novel mechanisms that link tPA, cell signaling, MMPs, and hemorrhagic transformation in the neurovascular unit. ..
- STRETCH-INDUCED CYCLOOXYGENASE-2 IN UROTHELIAL CELLsStephen Nakada; Fiscal Year: 2005..abstract_text> ..
- Signaling Pathways in Pathogenesis of Renal FibrosisJOSEPH GRANDE; Fiscal Year: 2004..If successful, these interventions may retard progression of tissue injury to end-stage disease. ..
- Signaling Mechanisms of TCDD-induced AHR ActivationYing Xia; Fiscal Year: 2007..abstract_text> ..
- NLR signaling in colitis and colorectal tumorigenesisThirumala Devi Kanneganti; Fiscal Year: 2013....
- Interactions and Dual Phosphorylation in MAP Kinase CascadesElizabeth J Goldsmith; Fiscal Year: 2010..Bisubstrate inhibitors, ATP-pTyr- peptide and ATP-pThr-peptide mimetics have been synthesized (by published chemistry) that will be used for crystallographic analysis bound to the MAP2K MEK6. ..
- Muller glia and neuronal regeneration in the retinaAndy Fischer; Fiscal Year: 2009..This information could be applied to not only stimulate neural regeneration to treat sight-threatening diseases of the retina, but also to control gliosis that may be detrimental to the pathogenesis of retinal disorders. ..
- A PROSPECTIVE STUDY OF ALASKA NATIVES & AMERICAN INDIANSMARTHA OR MARTY SLATTERY; Fiscal Year: 2006..The AIAN cohort will serve as a resource to enhance research and training activities of AIAN students interested in health research, health education, and general public health. ..
- DIET AND SOMATIC MUTATIONS IN COLON CANCERMARTHA OR MARTY SLATTERY; Fiscal Year: 2007..e. p53, K-ras, and microsatellite instability). Differences in colon and rectal tumors will be compared. Additionally data from rectal tumors will be combined with that from colon tumors to define disease pathways. ..
- Growth Factors and Colon CancerMARTHA OR MARTY SLATTERY; Fiscal Year: 2006..This study builds on a unique existing resource to study genetic and environmental associations with colorectal cancer. It will provide insight into colon cancer etiology and therefore avenues to disease prevention. ..
- FOUR-CORNERS BREAST AND ENDOMETRIAL CANCER STUDYMARTHA OR MARTY SLATTERY; Fiscal Year: 2003..C-peptide, glycosylated hemoglobin, IGF-1, and IGFBP3 will be evaluated with respect to breast and endometrial cancer in a subset of women. ..
- Plasminogen activators and cerebral ischemic injuryWilliam M Armstead; Fiscal Year: 2010....
- POTASSIUM CHANNELS AND CEREBRAL HEMODYNAMICS AFTER BRAINWilliam Armstead; Fiscal Year: 2005..These studies may lead to therapies for brain injured children. ..
- HIV PROTEASE INHIBITORS EFFECT--NENDOTHELIAL DYSFUNCTIONChangyi Chen; Fiscal Year: 2004..Together, the integrated basic science, non-human primate and human investigations offer a multi disciplinary approach to the understanding and prevention of protease inhibitor-associated vascular complications. ..
- MLK3 function in neurofibromatosis tumor cellsJohn Kyriakis; Fiscal Year: 2009..Alternatively, merlin could repress the recruitment of MLK3 by Rho family GTPases. In Aim 3, we will use biochemical and molecular biological methods to explore these possibilities. ..
- Overcoming DC defects in cancer patients by VEGF trapJeffrey Sosman; Fiscal Year: 2005..Thereby, the correlative studies described here may lead to the establishment of VEGF inhibition, VEGF Trap, specifically, as an approach to combine with and enhance cancer immunotherapy. ..
- DIETARY NUTRIENTS AS MODULATORS OF HEPATIC METABOLISMMichael Pagliassotti; Fiscal Year: 2001..Finally, to explain the decreased Km of G-6Pase for G6P during HS diet, and increased Vmax during HF diet, kinetics of this enzyme will be measured in the intact and disrupted microsomes. ..
- Role of SNAG Corepressors in Repression and OncogenesisKasirajan Ayyanathan; Fiscal Year: 2006..abstract_text> ..
- Fourteenth Ovarian WorkshopJohn Davis; Fiscal Year: 2002..New investigators will be invited to submit expanded abstracts that will be evaluated for scientific merit and competition for travel awards and the Cornelia P. Channing New Investigator Award. ..
- Examination of activating Met mutations in tumorigenesisCarrie Graveel; Fiscal Year: 2007..abstract_text> ..
- UNDERSTANDING STATUS EPILEPTICUSJaideep Kapur; Fiscal Year: 2002..4) Characterize the detailed pharmacological properties of dentate granule cell GABARs following SE. ..
- Control of embryonic stem cell self-renewal by Myc transcription factorsStephen Dalton; Fiscal Year: 2010..The following hESC lines from the NIH Human Embryonic Stem Cell Registry will be used in these studies;BG01, TEO3 and WAO1. ..
- Molecular Mechanisms of PAR1 DownregulationJoAnn Trejo; Fiscal Year: 2005..Thus we will use the C-tail of PAR1 as a probe in protein-protein interaction based strategies to identify new molecules that recognize and sort PAR1 to lysosomes...
- TRAINING IN AGE-RELATED NEURODEGENERATIVE DISEASESElliott Mufson; Fiscal Year: 2008..Finally the program will provide a broad-base of knowledge on neurodegenerative disorders as well as other instruction important for enhancing the interpersonal and professional skills of our trainees. ..
- ANGIOTENSIN AND CENTRAL NEUROHUMORAL ACTIVATION IN CHFRobert Felder; Fiscal Year: 2005..This work will provide new information concerning the role of the central nervous system in the pathophysiology of CHF and will draw attention to the possibility of CNS directed drug therapy for heart failure. ..
- Genetic effectors of TGF-beta induced growth and arrest.BEN H PARK; Fiscal Year: 2010..Isolated genes will be verified and validated by restoration of the putative gene and correlated with immunohistochemical studies using tissue microarrays. ..
- STUDY OF REG RECEPTOR-LIGAND BIOLOGY IN GI MUCOSABrian Dieckgraefe; Fiscal Year: 2008..These studies will also provide new insight into the role of Reg IV antagonists and lay the groundwork for development of therapeutic reagents active in gastrointestinal adenocarcinomas. ..
- NUTRIENT EFFECTS ON INSULIN ACTIONMichael Pagliassotti; Fiscal Year: 2009..abstract_text> ..
- Nongenomic Signaling Mechanisms of Environmental EstrogensCheryl S Watson; Fiscal Year: 2011..breast and pituitary cancers, infertility) must be understood so that exposures can be limited to safe levels. ..
- PPAR gamma Signaling and Lung Fibroblast TransdifferentiationVirender Rehan; Fiscal Year: 2009..abstract_text> ..
- THE STRESS-ACTIVATED PROTEIN KINASE PATHWAYJohn M Kyriakis; Fiscal Year: 2010..These studies will provide important details of a previously unknown signaling pathway required for inflammatory responses. ..
- Pathogenic Mechanisms of Shiga ToxinsVernon L Tesh; Fiscal Year: 2010..An improved understanding of how these toxins cause disease is necessary to formulate effective therapeutic agents to block disease progression. ..
- Inhibition of nf-kb signaling in melanoma therapyJeffrey Sosman; Fiscal Year: 2005..Abstract Not Provided ..
- QSTAR ELITE PRO HIGH PERFORMANCE QUADRUPOLE TIME-OF-FLIGHT MASS SPECTROMETERLin Yan; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Signal Transduction Mechanisms in Neuroendocrine NeuronsArshad Khan; Fiscal Year: 2006..This training will further my career goal of studying cellular signaling using an in vivo approach. ..
- Mentored Patient-Oriented Research Career Development AwZhenqi Liu; Fiscal Year: 2004....
- Fifteenth Ovarian WorkshopJohn Davis; Fiscal Year: 2004..New investigators will be invited to submit expanded abstracts that will be evaluated for scientific merit and competition for travel awards and the Cornelia P. Channing New Investigator Award. ..
- Action of Novel Anti-tumor Agents on Cell CommunicationDiane Matesic; Fiscal Year: 2005..abstract_text> ..
- TRANSMURAL SR REGULATION IN LV HYPERTROPHYDorothy Vatner; Fiscal Year: 2003..abstract_text> ..
- Pitt-SDM Research Infrastructure Improvement IntiativeMary Marazita; Fiscal Year: 2003..As the IIP is developed, potential collaborations with other components of the University of Pittsburgh will be also examined. ..
- BETA-ADRENERGIC SIGNALING, DENERVATION AND HEART FAILUREDorothy Vatner; Fiscal Year: 2002..Secondly, no study has systematically examined catecholamine desensitization mechanisms using a combination of in vivo studies and isolated myocytes for transmural physiology, biochemistry and molecular biology. ..
- GENE MAPPING STUDIES OF ORAL/FACIAL CLEFTS--CHINA/INDIAMary Marazita; Fiscal Year: 2002....
- EXERCISE AND SKELETAL MUSCLE FATTY ACID METABOLISMLORRAINE TURCOTTE; Fiscal Year: 2002..For the first time, malonyl-CoA levels will be correlated to the rate of fatty acid oxidation in skeletal muscle. ..
- IGF-I SIGNALING IN GRANULOSA CELLSJohn Davis; Fiscal Year: 2004..This new insight may uncover mechanistic defects that underlay disorders of folliculogenesis, premature ovarian failure and disorders such as polycystic ovarian syndrome. ..
- Role of Egr-1 in Corpus Luteum FunctionJohn Davis; Fiscal Year: 2006..abstract_text> ..
- MECHANISMS OF FIBER CARCINOGENESISTOM HEI; Fiscal Year: 2001..Cytogenetic and molecular alterations at the gene level will be analyzed from tumors and intermediate transformation stages to provide a mechanistic basis for tumor induction by mineral fibers. ..
- INHIBITION OF IFN GAMMA SIGNALING BY MYCOBACTERIAWilliam Lafuse; Fiscal Year: 2004..avium infected macrophages. 4) To determine the role of SOCS-3 in the inhibition of IFN-g signaling in M. avium infected macrophages. ..
- Oxidative Stress and ERK Signaling in AC-5 KO LongevityDorothy Vatner; Fiscal Year: 2006..Finding molecular switches, such as the one described in this project, could ameliorate disability with aging and would be a major step forward. [unreadable] [unreadable] [unreadable]..
- MECHANISMS OF ARSENIC CARCINOGENESISTOM HEI; Fiscal Year: 2005..abstract_text> ..
- Environmental Estrogens Acting via a Membrane ReceptorCHERYL WATSON; Fiscal Year: 2004..abstract_text> ..
- Regulation of Pulmonary Host Defense by LeptinPeter Mancuso; Fiscal Year: 2010..They will also test the use of exogenous leptin as an adjunctive therapeutic agent in the treatment of pneumococcal pneumonia. ..
- REGULATION OF LUNG SURFACTANT PROTEIN B GENE EXPRESSIONVijayakumar Boggaram; Fiscal Year: 2006..Such information may facilitate the development of newer therapies to treat lung dysfunction due to SP-B deficiency that occurs under conditions of elevated nitric oxide production in the lung. ..
- Genotype and Phenotype of Familial Nephropathy with GoutMary Marazita; Fiscal Year: 2005..abstract_text> ..
- Age and Gender Differences in Apoptosis and Stem CellsDorothy Vatner; Fiscal Year: 2008..In summary, this proposal will provide new conceptual information on gender differences with regard to compensatory adaptive mechanisms in the aging heart in a novel primate model. ..
- Dysregulation of AT, receptor in Transgenic RatsMICHELLE CLARK; Fiscal Year: 2004..abstract_text> ..
- Planning International Orofacial Cleft Genetic StudiesMary Marazita; Fiscal Year: 2007..g. power studies and sample size targets, research protocol and instruments), and will prepare the final research plan and submit a grant proposal to carry out the research project. [unreadable] [unreadable] [unreadable]..
- THE MUTAGENICITY OF MINERAL FIBERSTOM HEI; Fiscal Year: 2006..By using specific DNA probes of other genes that have been regionally mapped to various sites on chromosome 11, the molecular spectrum of mutations induced by either asbestos or glass fiber control will be compared. ..
- Activation of Sickle Red Cell AdhesionRahima Zennadi; Fiscal Year: 2006..Overall, these experiments will elucidate the molecular mechanisms of LW-mediated SS RBC adhesion to endothelium and leukocytes, and thus how physiologic stress and stress hormones may contribute to vaso-occlusion. ..
- Antioxidant Defense System and Leydig Cell AgingHaolin Chen; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Glutathione deficiency & immune dysfunction during agingRui Ming Liu; Fiscal Year: 2006....
- MECHANISMS OF TRANSFORMATION OF HEMATOPOIETIC CELLSJAMES MC CUBREY; Fiscal Year: 2001..An understanding of how these signal transduction and apoptotic pathways impinge upon one another will further our comprehension of the consequences of abnormal oncogene activation and tumor progression. ..
- MOLECULAR ANALYSIS OF ANCHORING PROTEINSJohn Scott; Fiscal Year: 2003....
- Molecular mechanism of ADNF and ADNP peptides in neuroprotection to alcoholYoussef Sari; Fiscal Year: 2008..This data will shed light on the mechanisms governing brain ontogeny and will pave the path toward potential therapeutics against developmental insults associated with prenatal alcohol exposure. [unreadable] [unreadable] [unreadable]..
- Ras/Raf & PI3K/Akt Induced Breast Cancer Drug ResistanceJAMES MC CUBREY; Fiscal Year: 2007..Throughthese studies,moreinformationwillbe availableto treatbreast andothercancerpatientswithcombinationsof drugs,whichinhibitsignaltransductionand anti-apoptoticpathwaysleadingtodrug resistance. ..
- The Exocyst in Synthesis, Cystogenesis and TubulogenesisJOSHUA LIPSCHUTZ; Fiscal Year: 2009..abstract_text> ..
- Gene Expression Changes in Early 3D Renal TubulogenesisJOSHUA LIPSCHUTZ; Fiscal Year: 2007..unreadable] [unreadable]..