Summary: Formation of MYELOID CELLS from the pluripotent HEMATOPOIETIC STEM CELLS in the BONE MARROW via MYELOID STEM CELLS. Myelopoiesis generally refers to the production of leukocytes in blood, such as MONOCYTES and GRANULOCYTES. This process also produces precursor cells for MACROPHAGE and DENDRITIC CELLS found in the lymphoid tissue.

Top Publications

  1. ncbi The phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin signaling network and the control of normal myelopoiesis
    Alberto M Martelli
    Department of Human Anatomy, University of Bologna, Bologna, Italy
    Histol Histopathol 25:669-80. 2010
  2. ncbi A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesis
    Francesco Fazi
    Department of Histology and Medical Embryology, University of Rome La Sapienza and San Raffaele Biomedical Science Park of Rome, Via di Castel Romano 100, 00128, Rome, Italy
    Cell 123:819-31. 2005
  3. ncbi Epigenetic silencing of the myelopoiesis regulator microRNA-223 by the AML1/ETO oncoprotein
    Francesco Fazi
    Department of Histology and Medical Embryology, University La Sapienza, Rome, 00161, Italy
    Cancer Cell 12:457-66. 2007
  4. pmc A myelopoiesis-associated regulatory intergenic noncoding RNA transcript within the human HOXA cluster
    Xueqing Zhang
    Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Blood 113:2526-34. 2009
  5. ncbi miR-142-3p prevents macrophage differentiation during cancer-induced myelopoiesis
    Nada Sonda
    Department of Surgery, Oncology and Gastroenterology, Oncology and Immunology Section, University of Padua, 35128 Padua, Italy
    Immunity 38:1236-49. 2013
  6. ncbi Irf8 regulates macrophage versus neutrophil fate during zebrafish primitive myelopoiesis
    Li Li
    State Key Laboratory of Molecular Neuroscience, Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, People s Republic of China
    Blood 117:1359-69. 2011
  7. ncbi Myelopoiesis in spleen-producing distinct dendritic-like cells
    Jonathan K H Tan
    Research School of Biology, The Australian National University, Canberra, ACT, Australia
    J Cell Mol Med 16:1924-33. 2012
  8. ncbi The ASXL-BAP1 axis: new factors in myelopoiesis, cancer and epigenetics
    O Abdel-Wahab
    Human Oncology and Pathogenesis Program and Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Leukemia 27:10-5. 2013
  9. ncbi Regulation of myeloid development and function by colony stimulating factors
    Daniel R Barreda
    Department of Biological Sciences, CW 405 Biological Sciences Building, University of Alberta, Edmonton, AB, Canada T6G 2E9
    Dev Comp Immunol 28:509-54. 2004
  10. pmc Social stress up-regulates inflammatory gene expression in the leukocyte transcriptome via β-adrenergic induction of myelopoiesis
    Nicole D Powell
    Division of Oral Biology, College of Dentistry, The Ohio State University, Columbus, OH
    Proc Natl Acad Sci U S A 110:16574-9. 2013

Detail Information

Publications233 found, 100 shown here

  1. ncbi The phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin signaling network and the control of normal myelopoiesis
    Alberto M Martelli
    Department of Human Anatomy, University of Bologna, Bologna, Italy
    Histol Histopathol 25:669-80. 2010
    ..We then further highlight the key role played by the PI3K/Akt/mTOR network during erythropoiesis, megakaryocytopoiesis, and granulo-cytopoiesis/monocytopoiesis...
  2. ncbi A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesis
    Francesco Fazi
    Department of Histology and Medical Embryology, University of Rome La Sapienza and San Raffaele Biomedical Science Park of Rome, Via di Castel Romano 100, 00128, Rome, Italy
    Cell 123:819-31. 2005
    ..Altogether, our data indicate that miR-223 plays a crucial role during granulopoiesis and point to the NFI-A repression as an important molecular pathway mediating gene reprogramming in this cell lineage...
  3. ncbi Epigenetic silencing of the myelopoiesis regulator microRNA-223 by the AML1/ETO oncoprotein
    Francesco Fazi
    Department of Histology and Medical Embryology, University La Sapienza, Rome, 00161, Italy
    Cancer Cell 12:457-66. 2007
    ..myeloid leukemia-associated fusion protein, display low levels of a microRNA-223 (miR-223), a regulator of myelopoiesis. Here, we show that miR-223 is a direct transcriptional target of AML1/ETO...
  4. pmc A myelopoiesis-associated regulatory intergenic noncoding RNA transcript within the human HOXA cluster
    Xueqing Zhang
    Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Blood 113:2526-34. 2009
    ..These findings suggest that HOTAIRM1 plays a role in the myelopoiesis through modulation of gene expression in the HOXA cluster.
  5. ncbi miR-142-3p prevents macrophage differentiation during cancer-induced myelopoiesis
    Nada Sonda
    Department of Surgery, Oncology and Gastroenterology, Oncology and Immunology Section, University of Padua, 35128 Padua, Italy
    Immunity 38:1236-49. 2013
    Tumor progression is accompanied by an altered myelopoiesis causing the accumulation of immunosuppressive cells...
  6. ncbi Irf8 regulates macrophage versus neutrophil fate during zebrafish primitive myelopoiesis
    Li Li
    State Key Laboratory of Molecular Neuroscience, Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, People s Republic of China
    Blood 117:1359-69. 2011
    ..One key unresolved question is what factors dictate polymorphonuclear versus mononuclear lineage fates during myelopoiesis. Here we show that during zebrafish embryogenesis interferon regulatory factor-8 (irf8) is expressed ..
  7. ncbi Myelopoiesis in spleen-producing distinct dendritic-like cells
    Jonathan K H Tan
    Research School of Biology, The Australian National University, Canberra, ACT, Australia
    J Cell Mol Med 16:1924-33. 2012
    ..A model is advanced for development of L-DC directly from haematopoietic progenitors in spleen and dependent on the spleen microenvironment...
  8. ncbi The ASXL-BAP1 axis: new factors in myelopoiesis, cancer and epigenetics
    O Abdel-Wahab
    Human Oncology and Pathogenesis Program and Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Leukemia 27:10-5. 2013
    ..Here, we highlight recent work revealing the critical function of BAP1 in restricting myelopoiesis and in regulating hematopoietic stem cell function...
  9. ncbi Regulation of myeloid development and function by colony stimulating factors
    Daniel R Barreda
    Department of Biological Sciences, CW 405 Biological Sciences Building, University of Alberta, Edmonton, AB, Canada T6G 2E9
    Dev Comp Immunol 28:509-54. 2004
    ..Although most of available knowledge about CSFs is on human and mouse CSFs, an attempt was made to integrate recent findings in other systems in order to highlight a more widespread role for CSFs throughout evolution...
  10. pmc Social stress up-regulates inflammatory gene expression in the leukocyte transcriptome via β-adrenergic induction of myelopoiesis
    Nicole D Powell
    Division of Oral Biology, College of Dentistry, The Ohio State University, Columbus, OH
    Proc Natl Acad Sci U S A 110:16574-9. 2013
    ..These results suggest that sympathetic nervous system-induced up-regulation of myelopoiesis mediates the proinflammatory component of the leukocyte CTRA dynamic and may contribute to the increased risk ..
  11. pmc CREB in the pathophysiology of cancer: implications for targeting transcription factors for cancer therapy
    Kathleen M Sakamoto
    Division of Hematology Oncology, Gwynne Hazen Cherry Memorial Laboratories, Mattel Children s Hospital UCLA, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA
    Clin Cancer Res 15:2583-7. 2009
    ..Although transcription factors have not been a central focus of drug development, recent advances suggest that CREB and other such proteins may be worthwhile targets for cancer therapy...
  12. ncbi Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis
    Frederic Pendino
    Department of Molecular Biology, University of Bergen, Bergen, Norway
    Blood 113:3172-81. 2009
    ..RINF expression correlates with retinoid-induced differentiation of leukemic cells and with cytokine-induced myelopoiesis of normal CD34(+) progenitors...
  13. pmc Macrophage activation and differentiation signals regulate schlafen-4 gene expression: evidence for Schlafen-4 as a modulator of myelopoiesis
    Wendy J van Zuylen
    The University of Queensland, Institute for Molecular Bioscience, Queensland, Australia
    PLoS ONE 6:e15723. 2011
    ..Little is known of their function, but previous studies suggest roles in immune cell development. In this report, we assessed Slfn regulation and function in macrophages, which are key cellular regulators of innate immunity...
  14. ncbi MicroRNA control of myelopoiesis and the differentiation block in acute myeloid leukaemia
    Catalina A Palma
    Blood, Stem Cells and Cancer Research, St Vincent s Hospital Centre for Applied Medical Research, St Vincent s Hospital, Darlinghurst, NSW, Australia
    J Cell Mol Med 16:978-87. 2012
  15. pmc Cutting edge: Type I IFN drives emergency myelopoiesis and peripheral myeloid expansion during chronic TLR7 signaling
    Matthew B Buechler
    Department of Immunology, University of Washington, Seattle, WA 98195, USA
    J Immunol 190:886-91. 2013
    ..In the bone marrow, TLR7.1 mice exhibited hallmarks of emergency myelopoiesis and contained a discrete population of Sca-1(+) GMP, termed emergency GMP, which are more proliferative and ..
  16. ncbi The emerging role of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling network in normal myelopoiesis and leukemogenesis
    Alberto M Martelli
    Department of Human Anatomy, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Biochim Biophys Acta 1803:991-1002. 2010
    ..emanating from the PI3K/Akt/mTOR cascade with the functions of hematopoietic stem cells and the process of myelopoiesis, including lineage commitment...
  17. ncbi Reintroduction of C/EBPalpha in leukemic CD34+ stem/progenitor cells impairs self-renewal and partially restores myelopoiesis
    Hein Schepers
    Division of Hematology, Department of Medicine, University Medical Center Groningen, Groningen, The Netherlands
    Blood 110:1317-25. 2007
    ..Together, our data indicate that low C/EBPalpha levels are necessary to maintain self-renewal and the immature character of AML stem cells...
  18. pmc Critical role of miR-9 in myelopoiesis and EVI1-induced leukemogenesis
    Vitalyi Senyuk
    Department of Medicine, and Cancer Research Center, University of Illinois, Chicago, IL 60621, USA
    Proc Natl Acad Sci U S A 110:5594-9. 2013
    ..Ectopic expression of miR-9 strongly accelerates terminal myelopoiesis and promotes apoptosis in vitro and in vivo...
  19. pmc Hyperglycemia promotes myelopoiesis and impairs the resolution of atherosclerosis
    Prabhakara R Nagareddy
    Division of Preventive Medicine and Nutrition, Department of Medicine, Columbia University, New York, NY 10032, USA
    Cell Metab 17:695-708. 2013
    ..with the receptor for advanced glycation end products on common myeloid progenitor cells, leads to enhanced myelopoiesis. Treatment of hyperglycemia reduces monocytosis, entry of monocytes into atherosclerotic lesions, and promotes ..
  20. pmc Mutant-specific gene programs in the zebrafish
    Gerhard J Weber
    Children s Hospital Stem Cell Program, Department of Hematology Oncology, Howard Hughes Medical Institute, Karp 7, 1 Blackfan Circle, Boston, MA 02115, USA
    Blood 106:521-30. 2005
  21. pmc Transcription of proteinase 3 and related myelopoiesis genes in peripheral blood mononuclear cells of patients with active Wegener's granulomatosis
    Chris Cheadle
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Arthritis Rheum 62:1744-54. 2010
    ..The aim of this study was to understand the biology underlying WG and to discover markers of disease activity that would be useful for prognosis and treatment guidance...
  22. pmc Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis
    Linda Yang
    Division of Experimental Hematology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Blood 110:3853-61. 2007
    ..Cdc42 activity is responsive to stimulation by SCF, IL3, SDF-1alpha, and fibronectin. The increased myelopoiesis and decreased erythropoiesis of the knockout mice are associated with an altered gene transcription program in ..
  23. ncbi Specification of the primitive myeloid precursor pool requires signaling through Alk8 in zebrafish
    Benjamin M Hogan
    Ludwig Institute for Cancer Research, Post Office Box 2008, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    Curr Biol 16:506-11. 2006
    ..We show here that the Bmp receptor lost-a-fin/alk8 is required for rostral pu.1 expression and myelopoiesis, identifying an early genetic event that distinguishes between the induction of anterior and posterior ..
  24. ncbi Zebrafish granulocyte colony-stimulating factor receptor signaling promotes myelopoiesis and myeloid cell migration
    Clifford Liongue
    School of Medicine, Deakin University, Waurn Ponds, Vic, Australia
    Blood 113:2535-46. 2009
    ..This contrasted with a posterior domain that was largely independent of this pathway. Definitive myelopoiesis was also partially dependent on a functional GCSF/GCSFR pathway...
  25. ncbi Differential regulation of primitive myelopoiesis in the zebrafish by Spi-1/Pu.1 and C/ebp1
    Fengyun Su
    Division of Hematology Oncology and Cellular and Molecular Biology Program, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    Zebrafish 4:187-99. 2007
    ..These data reveal strong functional conservation of pu.1 between zebrafish primitive myelopoiesis and mammalian definitive myelopoiesis...
  26. pmc Infection-induced myelopoiesis during intracellular bacterial infection is critically dependent upon IFN-γ signaling
    Katherine C MacNamara
    Wadsworth Center, New York State Department of Health, Albany, NY 12201, USA
    J Immunol 186:1032-43. 2011
    ..Finally, using mixed bone marrow chimeric mice, we show that IFN-γ-dependent infection-induced myelopoiesis occurs via the direct effect of the cytokine on developing myeloid cells...
  27. pmc Notch-dependent control of myelopoiesis is regulated by fucosylation
    Lan Zhou
    Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    Blood 112:308-19. 2008
    ..and their ligands clearly modulate T lymphopoietic decisions, evidence for their participation in modulating myelopoiesis is much less clear, and roles for posttranslational control of Notch-dependent signal transduction in ..
  28. ncbi Transcriptional regulation of a myeloid-lineage specific gene lysozyme C during zebrafish myelopoiesis
    Tetsuya Kitaguchi
    HMRO, Kyoto University Faculty of Medicine, Sakyo ku, Kyoto, Japan
    Mech Dev 126:314-23. 2009
    ..lines that drive enhanced green fluorescent protein (EGFP) to examine how lyz expression is regulated during myelopoiesis. We found that the 2.4kb lyz promoter is sufficient to drive myeloid-specific expression of EGFP in zebrafish...
  29. pmc FoxP3+ regulatory T cells restrain splenic extramedullary myelopoiesis via suppression of hemopoietic cytokine-producing T cells
    Jee H Lee
    Department of Comparative Pathobiology, Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA
    J Immunol 183:6377-86. 2009
    Extramedullary myelopoiesis occurs in peripheral organs such as spleen and produces many types of myeloid cells with diverse functions in response to inflammation and infection...
  30. ncbi MicroRNAs in normal and malignant myelopoiesis
    Elvira Pelosi
    Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Leuk Res 33:1584-93. 2009
    ..Extensive miRNA deregulation has been observed in leukemia and functional studies support a role for miRNAs in the pathogenesis of these disorders...
  31. pmc Gfi1 regulates miR-21 and miR-196b to control myelopoiesis
    Chinavenmeni S Velu
    Division of Immunobiology, Cincinnati Children s Hospital Medical Center, OH 45244, USA
    Blood 113:4720-8. 2009
    ..Thus, our results not only identify microRNAs whose regulation is required during myelopoiesis, but also provide an example of synergy in microRNA biologic activity and illustrate potential mechanisms ..
  32. pmc Myelopoiesis is regulated by osteocytes through Gsα-dependent signaling
    Keertik Fulzele
    Endocrine Unit, Massachusetts General Hospital, 50 Blossom St, Thier 1101, Boston, MA 02114, USA
    Blood 121:930-9. 2013
    ..Here we report that these cells regulate hematopoiesis, constraining myelopoiesis through a Gsα-mediated mechanism that affects G-CSF production...
  33. ncbi Enhanced normal short-term human myelopoiesis in mice engineered to express human-specific myeloid growth factors
    Paul H Miller
    Terry Fox Laboratory, BC Cancer Agency, Vancouver, BC, Canada
    Blood 121:e1-4. 2013
    ..Limiting dilution transplants further demonstrated that the early increase in human granulopoiesis in NSG-3GS mice reflects an expanded output of differentiated cells per STRC rather than an increase in STRC detection...
  34. ncbi Role of neutrophil elastase in bone marrow failure syndromes: molecular genetic revival of the chalone hypothesis
    Marshall Horwitz
    Division of Medical Genetics, Department of Medicine, University of Washington School of Medicine, Seattle 98195, USA
    Curr Opin Hematol 10:49-54. 2003
    ..The authors propose that neutrophil elastase acts as an inhibitor of myelopoiesis, substantiating a chalone hypothesis proposed many years ago.
  35. pmc Crebbp haploinsufficiency in mice alters the bone marrow microenvironment, leading to loss of stem cells and excessive myelopoiesis
    Stephanie N Zimmer
    Greehey Children s Cancer Research Institute, San Antonio, TX, USA
    Blood 118:69-79. 2011
    ..Our findings reveal that a full dose of Crebbp is essential in the BM microenvironment to maintain proper hematopoiesis and to prevent excessive myeloproliferation...
  36. ncbi MicroRNAs: key players of normal and malignant myelopoiesis
    Mir Farshid Alemdehy
    Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Curr Opin Hematol 19:261-7. 2012
    ..The main focus of the article is the function of some evolutionary conserved microRNAs that are abundantly expressed and tightly regulated during myelopoiesis.
  37. pmc Impaired myelopoiesis in mice lacking the repressors of translation initiation, 4E-BP1 and 4E-BP2
    Katie E Olson
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Immunology 128:e376-84. 2009
    ..of myeloid cells in vitro, highlight the pivotal role of 4E-BP1 and 4E-BP2 in the early phases of myelopoiesis. These results represent the first in vivo evidence of the involvement of translation in the early phases of ..
  38. ncbi Mast cell-deficient Kit(W-sh) "Sash" mutant mice display aberrant myelopoiesis leading to the accumulation of splenocytes that act as myeloid-derived suppressor cells
    Anastasija Michel
    Institute for Immunology, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany
    J Immunol 190:5534-44. 2013
    ..In this study, we demonstrate that Kit(W-sh) causes aberrant extramedullary myelopoiesis characterized by the expansion of immature lineage-negative cells, common myeloid progenitors, and granulocyte/..
  39. ncbi Overexpression of a hematopoietic transcriptional regulator EDAG induces myelopoiesis and suppresses lymphopoiesis in transgenic mice
    C Y Li
    Department of Biochemistry and Molecular Biology, Beijing Institute of Radiation Medicine, Beijing, China
    Leukemia 21:2277-86. 2007
    ..The myelopoiesis was enhanced with expansion of myeloid cells in BM, increased peripheral granulocytes and extramedullary ..
  40. ncbi Endogenous steroids are responsible for lactoferrin-induced myelopoiesis in mice
    Michał Zimecki
    Laboratory of Immunobiology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, PL 53 114 Wrocław, Poland
    Pharmacol Rep 61:705-10. 2009
    ..We conclude that LF-induced upregulation of endogenous steroid levels is responsible for the stimulation of myelopoiesis.
  41. ncbi Augmentation of myelopoiesis in a murine host bearing a T cell lymphoma following in vivo administration of proton pump inhibitor pantoprazole
    Naveen Kumar Vishvakarma
    School of Biotechnology, Banaras Hindu University, Varanasi 221 005, UP, India
    Biochimie 93:1786-96. 2011
    ..Thus, we studied the effect of in vivo administration of pantoprazole (PPZ), a PPI, on myelopoiesis in a murine model of a transplantable T cell lymphoma, designated as Dalton's lymphoma (DL)...
  42. ncbi Serglycin participates in retention of α-defensin in granules during myelopoiesis
    Andreas Glenthøj
    The Granulocyte Research Laboratory, Department of Hematology, National University Hospital, University of Copenhagen, Copenhagen, Denmark
    Blood 118:4440-8. 2011
  43. pmc The triterpenoid CDDO-Me promotes hematopoietic progenitor expansion and myelopoiesis in mice
    Erik Ames
    Department of Dermatology, University of California, Davis, Sacramento, California 95817, USA
    Biol Blood Marrow Transplant 18:396-405. 2012
    ..In the current study, we observed that CDDO-Me promoted myelopoiesis in both naive and transplanted mice...
  44. pmc Angiotensin-converting enzyme is required for normal myelopoiesis
    Chentao Lin
    Department of Biomedical Science, Cedars Sinai Medical Center, Los Angeles, California, USA
    FASEB J 25:1145-55. 2011
    ..abnormalities characterized by increased bone marrow myeloblasts and myelocytes, as well as extramedullary myelopoiesis. Peritoneal macrophages from ACE-KO mice were deficient in the production of effector molecules, such as tumor ..
  45. ncbi Effect of aspirin administration on reversal of tumor-induced suppression of myelopoiesis in T-cell lymphoma bearing host
    Anjani Kumar
    School of Biotechnology, Banaras Hindu University, Varanasi 221005, U P, India
    Blood Cells Mol Dis 48:238-46. 2012
    ..studied the effect of aspirin administration in tumor-bearing hosts on bone marrow cellularity and myelopoiesis. Aspirin administration to mice bearing a transplantable T-cell lymphoma, designated as Dalton's lymphoma (DL), ..
  46. ncbi Biology and management of transient abnormal myelopoiesis (TAM) in children with Down syndrome
    Anindita Roy
    Centre for Haematology, Imperial College London, London W12 0NN, UK
    Semin Fetal Neonatal Med 17:196-201. 2012
    ..leukaemia, which is clonally -related to the neonatal myeloproliferative syndrome, Transient Abnormal Myelopoiesis (TAM) unique to infants with DS...
  47. ncbi cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner
    W Wei Lynn Wong
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia
    Blood 123:2562-72. 2014
    ..To define the role of IAPs in myelopoiesis, we generated a mouse with cIAP1, cIAP2, and XIAP deleted in the myeloid lineage...
  48. ncbi Tumor-induced tolerance and immune suppression by myeloid derived suppressor cells
    Ilaria Marigo
    Department of Oncology and Surgical Sciences, Padova University, Padova, Italy, and Venetian Institute for Molecular Medicine, Padova, Italy
    Immunol Rev 222:162-79. 2008
    ..Based on observations of MDSCs, we present a time-structured and topologically consistent idea of tumor-dependent tolerance progression in tumor-bearing hosts...
  49. ncbi Notch signaling requires GATA-2 to inhibit myelopoiesis from embryonic stem cells and primary hemopoietic progenitors
    Renee F de Pooter
    Department of Immunology, University of Toronto, Sunnybrook and Women s Research Institute, 2075 Bayview Avenue, Toronto, Ontario, Canada
    J Immunol 176:5267-75. 2006
    ..that the addition of the Notch ligand Delta-like-1 (Dll-1) to an in vitro system that otherwise supports myelopoiesis, greatly reduces the myelopoietic potential of stem cells or uncommitted progenitors...
  50. ncbi Transcriptional regulation of myelopoiesis
    Alan D Friedman
    Division of Pediatric Oncology, Johns Hopkins University, Baltimore, Maryland 21231, USA
    Int J Hematol 75:466-72. 2002
    ..Several mechanisms orchestrate the myeloid developmental program, including cooperative gene regulation, protein:protein interactions, regulation of factor levels, and induction of cell cycle arrest...
  51. ncbi ADAM10 overexpression shifts lympho- and myelopoiesis by dysregulating site 2/site 3 cleavage products of Notch
    David R Gibb
    Department of Microbiology and Immunology, Virginia Commonwealth University, Massey Cancer Center, School of Medicine, Richmond, VA 23298, USA
    J Immunol 186:4244-52. 2011
    ..Collectively, these findings indicate that the differential cleavage of Notch into S2 and S3 products regulated by ADAM10 is critical to hematopoietic cell-fate determination...
  52. pmc Maternal pak4 expression is required for primitive myelopoiesis in zebrafish
    Sheran H W Law
    Section on Vertebrate Development, Program on Genomics of Differentiation, Eunice Kennedy Shriver National Institute of Child Health and Development, National Institutes of Health, Bethesda, MD, USA
    Mech Dev 130:181-94. 2013
  53. ncbi CD44-mediated hematopoietic progenitor cell adhesion and its complex role in myelopoiesis
    Andres Hidalgo
    Centro de Investigaciones Biologicas, Department of Immunology, Velazquez 144, 28006 Madrid, Spain
    J Hematother Stem Cell Res 11:539-47. 2002
    ..Instead, IM7.8.1 completely blocked myelopoiesis, whereas an anti-alpha 4 integrin mAb increased CFU-GM amounts...
  54. pmc Elucidating bone marrow edema and myelopoiesis in murine arthritis using contrast-enhanced magnetic resonance imaging
    Steven T Proulx
    University of Rochester, Rochester, New York 14642, USA
    Arthritis Rheum 58:2019-29. 2008
    ..In this study, MRI of murine arthritis was used to elucidate its cellular composition and vascular involvement...
  55. ncbi Lessons from congenital neutropenia: 50 years of progress in understanding myelopoiesis
    Nancy Berliner
    Division of Hematology, Brigham and Women s Hospital, Boston, MA, USA
    Blood 111:5427-32. 2008
    ..features and molecular pathophysiology of SCN closely parallels the progressive growth in our understanding of myelopoiesis. In this historical review, I have delineated this parallel progression in our understanding of the processes ..
  56. pmc Role for hepatic and circulatory ST6Gal-1 sialyltransferase in regulating myelopoiesis
    Mark B Jones
    Departments of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    J Biol Chem 285:25009-17. 2010
    ..We considered the possibility that myelopoiesis is responsive to the sialylation of liver-derived circulatory glycoproteins, such that reduced alpha2,6-..
  57. ncbi Identification of the CD33-related Siglec receptor, Siglec-5 (CD170), as a useful marker in both normal myelopoiesis and acute myeloid leukaemias
    Paul Virgo
    Department of Immunology and Immunogenetics, North Bristol, NHS Trust, Bristol, UK
    Br J Haematol 123:420-30. 2003
    ..All 13 acute lymphoblastic leukaemic (ALL) samples tested, including a CD33+ ALL, were Siglec-5 negative. These results support the further evaluation of Siglec-5 antibodies in the diagnosis and monitoring of AML...
  58. ncbi Zebrafish as a model for myelopoiesis during embryogenesis
    Jason N Berman
    Department of Pediatric Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Mass 02115, USA
    Exp Hematol 33:997-1006. 2005
    ..The conservation of genes such as scl, pu.1, c/ebpalpha, mpo, l-plastin, and lysozyme C in myelopoiesis and the corresponding expression patterns in zebrafish suggests that shared genetic pathways regulate this ..
  59. ncbi Treatment of human bone marrow with recombinant placenta immunoregulator ferritin results in myelopoiesis and T-cell suppression through modulation of the cytokine-chemokine networks
    Chaya Moroz
    Felsenstein Medical Research Center, Rabin Medical Center, Beilinson Campus, Sackler School of Medicine, Tel Aviv University, Petach Tikva, Israel
    Exp Hematol 34:159-66. 2006
    ..The aim of the current study was to investigate the regulatory effects of native placental ferritin (PLF), recombinant PLIF, and C48 on hematopoiesis of human bone marrow (BM)...
  60. ncbi Loss of gata1 but not gata2 converts erythropoiesis to myelopoiesis in zebrafish embryos
    Jenna L Galloway
    Stem Cell Program and Division of Hematology Oncology, Children s Hospital Boston, Dana Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Dev Cell 8:109-16. 2005
    ..Our studies establish a transcriptional hierarchy of Gata factor dependence during hematopoiesis and demonstrate that gata1 plays an integral role in directing myelo-erythroid lineage fate decisions during embryogenesis...
  61. ncbi Differential effects of steroids and retinoids on bovine myelopoiesis in vitro
    V Van Merris
    Department of Physiology, Biochemistry and Biometrics, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
    J Dairy Sci 87:1188-95. 2004
    ..Hydrocortisone reduced growth of granulocyte and monocyte colonies, whereas myelopoiesis was not altered by progesterone...
  62. ncbi Virally mediated MafB transduction induces the monocyte commitment of human CD34+ hematopoietic stem/progenitor cells
    C Gemelli
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
    Cell Death Differ 13:1686-96. 2006
    ..Altogether our data allow to conclude that MafB is a key regulator of human monocytopoiesis...
  63. ncbi Stroma-mediated dysregulation of myelopoiesis in mice lacking I kappa B alpha
    Rudolf A Rupec
    Department of Dermatology, University of Munich, Frauenlobstrasse 9 11, D 80337 Munich, Germany
    Immunity 22:479-91. 2005
    ..In summary, we show that cell-fate decisions leading to a premalignant hematopoietic disorder can be initiated by nonhematopoietic cells with inactive I kappa B alpha...
  64. pmc The NOTCH pathway contributes to cell fate decision in myelopoiesis
    Laurence Bugeon
    Imperial College London, London, SW7 2AZ, UK
    Haematologica 96:1753-60. 2011
    Controversy persists regarding the role of Notch signaling in myelopoiesis. We have used genetic approaches, employing two Notch zebrafish mutants deadly seven (DES) and beamter (BEA) with disrupted function of notch1a and deltaC, ..
  65. ncbi Chronic zinc deficiency in mice disrupted T cell lymphopoiesis and erythropoiesis while B cell lymphopoiesis and myelopoiesis were maintained
    Louis E King
    Department of Biochemistry and Molecular Biology, Room 419, Michigan State University, East Lansing, MI 48824 1319, USA
    J Am Coll Nutr 24:494-502. 2005
    The purpose of this study was to determine the impact of chronic zinc deficiency (ChrZD) on T and B cell lymphopoiesis, myelopoiesis and erythropoiesis in mice.
  66. ncbi IL-7 induces myelopoiesis and erythropoiesis
    Francesca B Aiello
    Laboratory of Molecular Immunoregulation, National Cancer Institute, Frederick, MD 21702, USA
    J Immunol 178:1553-63. 2007
    ..were shown to be involved because mice deficient in both GM-CSF and IL-3 also responded to IL-7 with increased myelopoiesis. Candidate cytokines included IFN-gamma and Flt3 ligand, which were also produced in response to IL-7...
  67. ncbi Expression of myelopoiesis-associated microRNA in bone marrow cells of atypical chronic myeloid leukaemia and chronic myelomonocytic leukaemia
    Kais Hussein
    Institute of Pathology, Hannover Medical School, Carl Neuberg Strasse 1, Hannover, Germany
    Ann Hematol 90:307-13. 2011
    ..b>Myelopoiesis-associated miR-10a, miR-17-5p, miR-155, miR-223 and miR-424 were analysed by real-time polymerase chain ..
  68. pmc Inositol trisphosphate 3-kinase B (InsP3KB) as a physiological modulator of myelopoiesis
    Yonghui Jia
    Department of Pathology, Dana Farber Harvard Cancer Center, Children s Hospital Boston and Joint Program in Transfusion Medicine, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:4739-44. 2008
    ..Here, we demonstrate that InsP3KB is also a physiological modulator of myelopoiesis. The InsP3KB gene is expressed in all hematopoietic stem/progenitor cell populations...
  69. pmc Critical roles of lysosomal acid lipase in myelopoiesis
    Peng Qu
    Center for Immunobiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Pathol 176:2394-404. 2010
    ..These results provide evidence that LAL is an important regulator of myelopoiesis during hematopoietic development, differentiation, and homeostasis.
  70. pmc Integrated analysis of microRNA and mRNA expression profiles in physiological myelopoiesis: role of hsa-mir-299-5p in CD34+ progenitor cells commitment
    E Tenedini
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
    Cell Death Dis 1:e28. 2010
    ..Gain- and loss-of-function experiments revealed that hsa-miR-299-5p participates in the regulation of hematopoietic progenitor fate, modulating megakaryocytic-granulocytic versus erythroid-monocytic differentiation...
  71. pmc C/EBPalpha initiates primitive myelopoiesis in pluripotent embryonic cells
    Yaoyao Chen
    Healing Foundation Centre, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
    Blood 114:40-8. 2009
    ..Thus, C/EPBalpha is the first known single factor capable of initiating an entire myelopoiesis pathway in pluripotent cells in the embryo.
  72. ncbi The ubiquitin ligase Triad1 inhibits myelopoiesis through UbcH7 and Ubc13 interacting domains
    J A Marteijn
    Central Hematology Laboratory, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Leukemia 23:1480-9. 2009
    ..The differential interaction of the RINGs with Ubcs strongly suggests that the ubiquitination mediated through UbcH7 as well as Ubc13 plays a major role in myelopoiesis.
  73. ncbi Transcriptional regulation in myelopoiesis: Hematopoietic fate choice, myeloid differentiation, and leukemogenesis
    Alan G Rosmarin
    Department of Medicine, Brown Medical School, Providence, RI, USA
    Exp Hematol 33:131-43. 2005
    ..1 and C/EBPalpha contribute directly to development of acute myelogenous leukemia. Thus, normal myeloid development and acute leukemia are now understood to represent opposite sides of the same hematopoietic coin...
  74. ncbi Transient abnormal myelopoiesis complicated by tumor lysis syndrome
    Yoshifusa Abe
    Division of Neonatology, Chiba Children s Hospital, Chiba, Japan
    Pediatr Int 48:489-92. 2006
  75. ncbi EVI1 Impairs myelopoiesis by deregulation of PU.1 function
    Leopoldo Laricchia-Robbio
    Department of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Cancer Res 69:1633-42. 2009
    ..Here, we have examined the expression of several genes activated during terminal myelopoiesis in BM cells and identified a group of them that are altered by EVI1...
  76. ncbi Inverse relationship between myeloid maturation and leukotriene C4 synthase expression in normal and leukemic myelopoiesis-consistent overexpression of the enzyme in myeloid cells from patients with chronic myeloid leukemia
    Susanne Tornhamre
    Division of Physiological Chemistry II, Department of Medical Biochemistry and Biophysics, Scheele Laboratory, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Exp Hematol 31:122-30. 2003
    ..The aim of this study was to clarify the expression of LTC(4)S during normal and leukemic myelopoiesis and to investigate the correlation between abnormal LTC(4)S expression in CML myeloid cells and the activity of ..
  77. ncbi Regulation of myelopoiesis through syntenin-mediated modulation of IL-5 receptor output
    Jeffrey M Beekman
    Molecular Immunology Laboratory, Department of Immunology, Wilhelmina Childrens Hospital, University Medical Centre Utrecht, Utrecht, The Netherlands
    Blood 114:3917-27. 2009
    ..These data demonstrate that cytokine-specific functions can be transduced by unique receptor alpha-chain-associating adapter proteins...
  78. pmc Genomic expression during human myelopoiesis
    Francesco Ferrari
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Via G, Campi 287, 41100, Modena, Italy
    BMC Genomics 8:264. 2007
    Human myelopoiesis is an exciting biological model for cellular differentiation since it represents a plastic process where multipotent stem cells gradually limit their differentiation potential, generating different precursor cells which ..
  79. pmc Critical roles for IFN-beta in lymphoid development, myelopoiesis, and tumor development: links to tumor necrosis factor alpha
    Raj Deonarain
    Toronto General Research Institute, University Health Network, Toronto, ON, Canada MG5 2M1
    Proc Natl Acad Sci U S A 100:13453-8. 2003
    ..Taken altogether, our data suggest that, in addition to the direct growth-inhibitory effects on tumor cells, IFN-beta is required during different stages of maturation in the development of the immune system...
  80. ncbi STAT5-induced self-renewal and impaired myelopoiesis of human hematopoietic stem/progenitor cells involves down-modulation of C/EBPalpha
    Albertus T J Wierenga
    Department of Hematology, University Medical Center Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
    Blood 107:4326-33. 2006
    ..5 (STAT5A) in human cord blood (CB)-derived stem/progenitor cells results in enhanced self-renewal and impaired myelopoiesis. The present study identifies C/EBPalpha as a critical component that is down-regulated by STAT5...
  81. ncbi Euphorbia tirucalli L. modulates myelopoiesis and enhances the resistance of tumour-bearing mice
    Marize C Valadares
    Departamento de Farmacologia Hemocentro, Faculdade de Ciencias Medicas, FCM, Universidade Estadual de Campinas, UNICAMP, Campinas, SP, Brazil
    Int Immunopharmacol 6:294-9. 2006
    ..Treatment of these animals with Euphorbia tirucalli L. (ET) (125, 250 and 500 mg/kg) stimulated marrow myelopoiesis and reduced spleen colony formation, with no differences observed between the effects of the three doses...
  82. pmc Identification of regulatory functions for 4-1BB and 4-1BBL in myelopoiesis and the development of dendritic cells
    Seung Woo Lee
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    Nat Immunol 9:917-26. 2008
    ..and its ligand 4-1BBL can control adaptive immunity, but here we show that their interaction also suppressed myelopoiesis. We found that 4-1BBL was expressed on hematopoietic stem cells, differentiating common myeloid progenitors and ..
  83. ncbi Genetic regulators of myelopoiesis and leukemic signaling identified by gene profiling and linear modeling
    Anna L Brown
    Haematology and Oncology Program, Child Health Research Institute, North Adelaide, South Australia
    J Leukoc Biol 80:433-47. 2006
    ..between proliferation and self-renewal versus growth suppression and differentiation during normal and leukemic myelopoiesis are not understood...
  84. ncbi Deciphering developmental stages of adult myelopoiesis
    Cornelis J Pronk
    Institution for Experimental Medical Science, Immunology Section, Lund University, Lund, Sweden
    Cell Cycle 7:706-13. 2008
    ..When functionally evaluated, such early granulocyte/monocyte precursors displayed a latent lymphoid activity, which was pronounced in subsets bearing high expression of the tyrosine kinase receptor FLT3...
  85. ncbi Endotoxemia down-regulates bone marrow lymphopoiesis but stimulates myelopoiesis: the effect of G6PD deficiency
    Rachna Chandra
    Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ 07103, USA
    J Leukoc Biol 83:1541-50. 2008
    ..LPS-induced down-regulation of B cell production contributes to the generalized lymphopenia and lymphocyte dysfunction observed following nonspecific immune challenges...
  86. ncbi Notch signaling in embryonic and adult myelopoiesis
    Ralf Schwanbeck
    Department of Biochemistry, Christian Albrechts Universitat zu Kiel, Kiel, Germany
    Cells Tissues Organs 188:91-102. 2008
    ..components and mechanisms of the Notch signaling pathway and discuss the role of Notch in embryonic and adult myelopoiesis. Finally, we will focus on mediators of Notch signaling in the hematopoietic system...
  87. ncbi Retinoic acid signaling in myelopoiesis
    Karen Drumea
    Warren Alpert Medical School, Brown University, Providence, Rhode Island, USA
    Curr Opin Hematol 15:37-41. 2008
    ..We have not attempted to summarize the related clinical literature...
  88. ncbi p15Ink4b: dual function in myelopoiesis and inactivation in myeloid disease
    Michael Rosu-Myles
    Center for Cancer Research, National Cancer Institute, NIH, Building 37, Room 4124A, 37 Convent Drive MSC 4263, Bethesda, MD 20892 4263, USA
    Blood Cells Mol Dis 40:406-9. 2008
    ..Here we outline the mechanisms by which p15 is silenced and the functions of this CDKI in myelopoiesis as well as discuss the implications of these findings to myeloid disease.
  89. ncbi A novel polysaccharide of black soybean promotes myelopoiesis and reconstitutes bone marrow after 5-flurouracil- and irradiation-induced myelosuppression
    Hui Fen Liao
    Department of Medical Research, Mackay Memorial Hospital, Taipei 251, Taiwan
    Life Sci 77:400-13. 2005
    The aim of this study was to investigate the promotion of myelopoiesis by an active polysaccharide of black soybean (PSBS)...
  90. ncbi Protein kinase B (c-akt) regulates hematopoietic lineage choice decisions during myelopoiesis
    Miranda Buitenhuis
    Molecular Immunology Lab, Department of Immunology, University Medical Center, Utrecht, The Netherlands
    Blood 111:112-21. 2008
    ..system was used to investigate the role of PI3K and its downstream effector, protein kinase B (PKB/c-akt) in myelopoiesis. PI3K activity was essential for hematopoietic progenitor survival...
  91. ncbi Four cases of fetal hypoechoic hepatomegaly associated with Trisomy 21 and transient abnormal myelopoiesis
    Akira Kikuchi
    Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Prenat Diagn 27:665-9. 2007
    ..Our objective was to determine the clinical significance of fetal hypoechoic hepatomegaly and serial change of liver sizes...
  92. ncbi Gangliosides of the stroma layer participate in the interferon-gamma receptor-dependent controls of myelopoiesis
    Claudia M B Andrade
    Departamento de Bioquimica, Instituto de Ciências Básicas da Saúde ICBS, Universidade Federal do Rio Grande do Sul UFRGS, Rua Ramiro Barcelos, 2600 Anexo, CEP 90035 003 Porto Alegre, RS, Brazil
    Biochim Biophys Acta 1761:1030-40. 2006
    Stroma-mediated myelopoiesis depends upon growth-factors and an appropriate intercellular microenvironment, whose polarity is relevant for granulocyte-macrophage colony stimulating factor (GM-CSF) mediated myeloid cell proliferation...
  93. ncbi Determinants of lymphoid-myeloid lineage diversification
    Catherine V Laiosa
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Annu Rev Immunol 24:705-38. 2006
  94. ncbi Effect of thermal injury on splenic myelopoiesis
    John G Noel
    Research, Shriners Hospital for Children, 3229 Burnet Avenue, Cincinnati, OH 45229, USA
    Shock 23:115-22. 2005
    ..Our work clearly shows that the increased myelopoiesis observed postinjury leads to the production of mature myeloid cells...
  95. ncbi Overexpression of murine TSLP impairs lymphopoiesis and myelopoiesis
    Mark J Osborn
    Department of Laboratory Medicine and Pathology, Division of Medical Technology, University of Minnesota, BSBE 6 118, 312 Church Street SE, Minneapolis, MN 55455, USA
    Blood 103:843-51. 2004
    ..Overexpression of TSLP disrupted hematopoietic homeostasis by causing imbalances in lymphopoiesis and myelopoiesis. Mice harboring a TSLP transgene had 5- to 700-fold fewer B and T precursors and no detectable pre-B lymphocyte ..
  96. ncbi Integrin engagement-induced inhibition of human myelopoiesis is mediated by proline-rich tyrosine kinase 2 gene products
    Scott J Dylla
    Stem Cell Institute and Department of Medicine, University of Minnesota, Minneapolis, Minn, USA
    Exp Hematol 32:365-74. 2004
    ..Here we investigated whether PYK2 gene products mediate integrin signaling in hematopoietic stem and progenitor cells...
  97. pmc Enhanced osteoclast development in collagen-induced arthritis in interferon-gamma receptor knock-out mice as related to increased splenic CD11b+ myelopoiesis
    Bert De Klerck
    Laboratory of Immunobiology, Rega Institute, Katholieke Universiteit Leuven, Leuven, Belgium
    Arthritis Res Ther 6:R220-31. 2004
    ..They also provide a plausible explanation for the higher susceptibility of IFN-gammaR KO mice to CIA...
  98. ncbi Cotransplantation of human mesenchymal stem cells enhances human myelopoiesis and megakaryocytopoiesis in NOD/SCID mice
    Maria Angelopoulou
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520 8035, USA
    Exp Hematol 31:413-20. 2003
    ..Because cotransplantation of marrow-derived stromal cells has been shown to enhance engraftment of human hematopoietic stem cells, we hypothesized that cotransplantation of MSC could enhance platelet and myeloid cell development...
  99. ncbi Transcriptional regulators and myelopoiesis: the role of serum response factor and CREB as targets of cytokine signaling
    Patricia Mora-Garcia
    Department of Pediatrics, Division of Hematology Oncology, Mattel Children s Hospital, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Stem Cells 21:123-30. 2003
  100. pmc A critical function for B-Raf at multiple stages of myelopoiesis
    Tamihiro Kamata
    Department of Laboratory Medicine, University of California, San Francisco, 513 Parnassus Ave, Room S 577, San Francisco, CA 94143 0100, USA
    Blood 106:833-40. 2005
    ..Together, these data suggest that B-Raf plays a cell-autonomous role in megakaryocytopoiesis and a permissive role in myeloid progenitor development...
  101. ncbi c-FMS chromatin structure and expression in normal and leukaemic myelopoiesis
    George Alexander Follows
    Molecular Medicine Unit, St James s University Hospital, Leeds, UK
    Oncogene 24:3643-51. 2005
    ..element located within the second intron (FIRE - fms intonic regulatory element) during normal and leukaemic myelopoiesis. Granulocytic differentiation from normal and leukaemic precursors is accompanied by loss of transcription ..

Research Grants64

    Nancy Berliner; Fiscal Year: 2001 further characterize the interaction of CDP and C/EBP in regulating stage specific gene expression during myelopoiesis. We will also determine the role of CDP and C/EBPa in abnormal states characterized by global failure of ..
  2. Molecular Mechanism of Immune Therapy for Bone Marrow Failures
    Pearlie K Epling-Burnette; Fiscal Year: 2013
    ..was that an antigen, presumably a common antigen on myeloid progenitors was responsible for suppression of myelopoiesis. This was thought to be due to the direct interaction between this "putative myeloid-specific antigen" and the ..
  3. Inflammation and Immunosuppression in Lung Cancer
    Cong Yan; Fiscal Year: 2013
    ..A defect in myelopoiesis with increased myeloid progenitor cells was observed in the lal-/- bone marrow...
  4. HoxA10 Function During Myeloid Differentiation
    ELIZABETH ANN EKLUND; Fiscal Year: 2011
    ..Various hematopoietic cytokines induce HoxA10 tyrosine-phosphorylation during myelopoiesis. Since tyrosine-phosphorylation decreases HoxAIO-binding the negative cis elements in these oxidase genes, ..
  5. Regulation and function of nuclear envelope proteins in myelopoiesis and leukemia
  6. Mechanisms of PASG-Mediated Senescence in Hematopoietic Development and Leukemia
    ROBERT JOHN ARCECI; Fiscal Year: 2010
    ..that the deletion variant of PASG observed in leukemia can alter epigenetic patterning in somatic cells during myelopoiesis and contribute to the development and behavior of leukemia;3) determine the frequency and expression level of ..
    DAVID W CLAPP; Fiscal Year: 2012
    ..If the hypothesis is correct, we would predict that developing small molecules that inhibit Pak1 function could be useful as a molecular therapy for treatment of plexiform neurofibromas. ..
  8. Mucosal Mechanisms Linking Pulmonary and Gastrointestinal Inflammation/Immunity
    Gary B Huffnagle; Fiscal Year: 2010
    ..and/or manifestation of immune responses in the airways, including changes in regulatory T cell responses and myelopoiesis. In this proposal, we will investigate two potential mechanisms of how the inflammatory response to a gut-..
  9. Molecular Mechanism of Severe Congenital Neutropenia
    H Grimes; Fiscal Year: 2009
    ..Finally, we will molecularly characterize ELA2 as a GFI1-target gene in myelopoiesis, and we will biologically test suggested genetic interactions...
  10. Chaperone Mechanisms in Innate Immunity
    Zihai Li; Fiscal Year: 2013
    ..of both TLRs and integrins in gp96 KO murine cells;(iv) gp96 is critical for T and B lymphopoiesis but not myelopoiesis;(v) the folding of TLRs by gp96 is dependent on a substrate (TLR)-specific co-chaperone, CNPY3 (also known as ..
  11. Crosstalk between glioma cells &immune cells in the tumor microenvironment: Ther
    Maria G Castro; Fiscal Year: 2013
    ..Expansion of MDSCs can be triggered by factors produced by the tumor cells themselves, which stimulate myelopoiesis and inhibit the differentiation of mature myeloid cells...
  12. Role of MN1-TEL and MN1 in Leukemogenesis
    Gerard C Grosveld; Fiscal Year: 2010
    ..Mn1 knockout mice we will be used to determine the role of Mn1 in normal myelopoiesis. By using retroviral mutagenesis and introduction of directed mutations we will determine which genetic lesions ..
  13. Oral Agents to Stimulate Neutrophil Production
    SUSAN PARK PERRINE; Fiscal Year: 2010
    ..Recently, select Hemokines were also found to stimulate myelopoiesis in cytokine-dependent human and murine myeloid cell lines, in hematopoietic progenitors cultured from normal ..
  14. The Role of CREB in Normal Myelopoiesis and Leukemogenesis
    KATHLEEN MIHO SAKAMOTO; Fiscal Year: 2013
    ..These studies will provide new insights into how CREB regulates normal hematopoiesis and contributes to leukemogenesis. ..
  15. Stat3 Isoforms in Maturation and Survival of Normal and Malignant Myeloid Cells
    Michele S Redell; Fiscal Year: 2012
    ..Understanding the functions of StatS isoforms in myelopoiesis and leukemogenesis will be crucial for directing future efforts at therapies targeted to signaling pathways, ..
  16. Biosynthesis and Function of Lactosaminyl Glycans in Hematopoiesis
    Robert Sackstein; Fiscal Year: 2013 hematopoiesis enabling transformative therapeutic strategies to custom-modify surface glycans to optimize myelopoiesis and thrombopoiesis, will expand glycan analytical resources, and will also fundamentally serve to mentor/..
  17. The influence of the ZXDC protein on myelopoiesis
    Joseph D Fontes; Fiscal Year: 2012
    ..this proposal is to identify the mechanisms by which the zinc finger X-linked duplicated C (ZXDC) gene affects myelopoiesis. One ZXD family member, ZXDC, interacts with at least two key transcription factors in myeloid cell development:..
  18. Regulation of Granulopoiesis by Fucosylation-Dependent Notch Signaling
    Lan Zhou; Fiscal Year: 2012
    ..This will be the first study to define the signaling transduction pathways controlling myelopoiesis that are activated in bone marrow stem and progenitor cells after engagement of fucosylated glycoprotein, such ..
  19. Targeting the C/EBPalpha-Gfi-pathway in CML stem cells
    Bruno Calabretta; Fiscal Year: 2013 required for regulation of the balance between differentiation and proliferation during the early stages of myelopoiesis. The importance of this function is demonstrated by the observation that C/EBP[unreadable] is genetically or ..
  20. Role of TET2 in normal hematopoiesis and pathogenesis of myeloid malignancies
    Mingjiang Xu; Fiscal Year: 2013
    ..We, therefore, hypothesize that Tet2 acts as a tumor suppressor in myelopoiesis by regulating the behavior of HSC...
  21. IRF-8 as a Negative Regulator of CD11b+Gr-1+ Myeloid Cell Production and Function
    Scott I Abrams; Fiscal Year: 2013
    ..revealed an essential role for IRF-8, a member of the IRF family of transcription factors, in regulating normal myelopoiesis. The impact of IRF-8 in myelopoiesis has been clearly illuminated by alteration of the gene in mouse models...
  22. Effects of Microbial Exposure on Myelopoiesis
    HELEN SARA GOODRIDGE; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Myelopoiesis replenishes peripheral supplies of myeloid phagocytes in the steady-state, as well as in response to increased demand during infection...
  23. Defining the Mechanisms by Which Plateletes Regulate Angiogenesis
    Elisabeth M Battinelli; Fiscal Year: 2013
    ..In addition to her role as Director, she has a long-term expertise in myelopoiesis and has mentored a large number of young investigators...
  24. MicroRNAs regulating erythroid development
    Curt I Civin; Fiscal Year: 2010
    ..Mir-155 potently reduced both myelopoiesis and erythropoiesis of normal human HSPCs, and mir-16 selectively inhibited erythropoiesis...
  25. The Role of 4-1BB in T Cell and APC Interactions
    Michael Croft; Fiscal Year: 2010
    ..The molecular basis of these inhibitory activities are unknown. We have found that suppression of myelopoiesis and DC differentiation is due to 4-1BBL delivering inhibitory signals to bone marrow progenitor cells...
    Alan Friedman; Fiscal Year: 2004
    ..C/EBPalpha (C/EBPa) and PU.1 are key regulators of myelopoiesis. C/EBPa null mice lack granulocytes, and PU.1 null mice lack B cells, granulocytes, and monocytes...
    Richard Gamelli; Fiscal Year: 2007
    ..Our group has demonstrated a significant role for bone marrow myelopoiesis (a developmental program that is responsible for the continuous production of many leukocytes) in the ..
  28. Carbohydrate-Dependent Adhesion in Normal and Tumor Cells
    Minoru Fukuda; Fiscal Year: 2012
    ..The work centers around sulfated, fucosylated glycoconjugates in lymphocyte trafficking, tumor progression, and myelopoiesis. The work includes the role of carbohydrate-mediated signal transduction, a novel aspect in the field, through ..
  29. Genetic Basis of Myeloid Neoplasia--Mutagenesis Screens
    A Look; Fiscal Year: 2005
    ..a deficiency or abnormal distribution of circulating granulocytes, implicating genes important in vertebrate myelopoiesis; and (Ii) a subset of the genes discovered by this method will have human counterparts that contribute to ..
    DAVID CLAPP; Fiscal Year: 2001
    Alan Miller; Fiscal Year: 1991
    ..The results of these studies will enhance our knowledge of normal and neoplastic regulation and will serve to focus future studies on the molecular genetics of altered regulation in leukemic cells...
    Kenneth Dorshkind; Fiscal Year: 1991
    ..The Dexter myeloid bone marrow cultures (MBMC) are optimal for myelopoiesis. No B cells are produced in this system but an early B cell precursor is maintained...
    Steven Ackerman; Fiscal Year: 2006
    ..basic protein (MBP) genes as models for defining the eosinophil developmental program in the general context of myelopoiesis. Three specific questions (aims) are proposed: (1) What are the transcription factors, their interactions and ..
  34. Signal Transduction by Cytokine Receptors in Vivo
    Warner Greene; Fiscal Year: 2004
    ..profiling and analysis of genetically modified mouse lines will establish whether specific contributions to myelopoiesis in vivo can be assigned to singular gene targets of this receptor...
    Pamela Fraker; Fiscal Year: 2007
    ..We also suspect phenotypic analysis of progenitor cells in ZD mice will show they are also skewed towards myelopoiesis. 2...
    Kenneth Dorshkind; Fiscal Year: 1993
    ..In vivo studies have shown that CSFs stimulate myelopoiesis, but secondary effects on other lineages, particularly lymphopoiesis, have not been examined in detail...
  37. Targeted Therapy of Lyn in Myelodysplastic Syndrome
    SETH JOEL COREY; Fiscal Year: 2010
    ..Therefore, we hypothesize that disordered myelopoiesis due to dysfunctional G-CSF Receptor signaling underlies some cases of MDS and that targeted therapy may ..
  38. Cyclin A1 as a Target in AML and Other Cancers
    DEBRA WOLGEMUTH; Fiscal Year: 2003
    ..The transgenic animals exhibited abnormal myelopoiesis and developed acute myeloid leukemia...
    Scott White; Fiscal Year: 1999
    Granulocyte colony-stimulating factor (G-CSF), by dimerizing its receptor (G-CSFR), effects all stages of myelopoiesis. Two functionally distinct regions within the cytoplasmic domain exist...
  40. Hsal 2, A Novel Homeobox Gene in Hematopoiesis
    Li Chai; Fiscal Year: 2007
    The long-term goal of this proposal is to define the role of Hsal2 in myelopoiesis. Hsal2 is a recently identified divergent homeobox gene that has sequence homology to the Sal homeobox gene in Drosophila...
    Robert Moore; Fiscal Year: 1990
    ..colony-stimulating factors (CSFs) have been considered, since their discovery, to be growth factors promoting myelopoiesis. However, there have been isolated reports suggesting that various CSFs can elicit alterations in the ..
    Richard Steinman; Fiscal Year: 1999
    ..Specific aims of this proposal are: 1. To determine the stage specific expression of p21 in myelopoiesis and define the relationship of p21 expression to cell cycle stage and to the presence of CD11b, CD14, and CD15 ..
    Carlos Ferrario; Fiscal Year: 2004
    ..In Specific Aim 3 they will evaluate whether blockade of the AT1 receptor alters bone marrow myelopoiesis and expression of the bone marrow RAS in hypercholesterolemic cynomolgus monkeys treated with an AT1 receptor ..
  44. The Role of Cyclin A1 in Acute Myeloid Leukemia
    DEBRA WOLGEMUTH; Fiscal Year: 2006
    ..They exhibited abnormal myelopoiesis and developed acute myeloid leukemia with low penetrance and long latency...
  45. Adrenergic Modulation Of Myelopoiesis In Burn & Sepsis
    Stephen Jones; Fiscal Year: 2004
    ..and experimental thermal injury and adrenergic stimulation modulates immune cell function, cytokine release and myelopoiesis under non-stressed conditions there is a lack of information on bone marrow noepinephrine (NE) release during ..
    E Wilson; Fiscal Year: 1991
    ..The data generated during this project will yield new insights into the regulation of both normal leukemic myelopoiesis.
  47. The Protein Kinase C Pathway In Acute Leukemia
    AMANDA REDIG; Fiscal Year: 2009 define the expression of different PKC-isoforms during early and late stages of normal erythropoiesis and myelopoiesis, and to examine the effects of disruption of their expression or inhibition of their kinase activities on ..
    Daniel G Tenen; Fiscal Year: 2010
    ..The long range goals are to further our understanding of the mechanisms involved in myelopoiesis and leukemia by understanding the transcription factors which regulate myeloid development from stem cells...
    PHILIP FURMANSKI; Fiscal Year: 1999
    ..Many other diverse activities have been attributed to Lf, from feedback control of myelopoiesis to regulation of NK and macrophage function...
    Erik Nelson; Fiscal Year: 2000
    ..We wish to increase our understanding of normal myelopoiesis at the molecular level, and correlate this with leukemogenesis...
    Archibald Perkins; Fiscal Year: 2004
    ..We have shown that Evi-1 can blunt the accumulation of C/ebpalpha mRNA during myelopoiesis; C/ebpalpha encodes a transcriptional regulatory protein that is essential for the generation of mature ..
  52. Regulation of Hematopoiesis by Notch Receptors
    James Griffin; Fiscal Year: 2007
    ..Over the initial five years of this grant (1984-88), our aims were to identify the major cytokines affecting myelopoiesis and determine their major biological properties first in vitro, and then in vivo in human subjects...
    James Griffin; Fiscal Year: 1990
    ..The information generated by this project will provide an improved understanding of the role of CSFs in myelopoiesis, the types of cells that regulate myelopoiesis, and the basic mechanisms of CSF gene regulation...
    M Simon; Fiscal Year: 2002
    ..1 is regulated during lymphopoiesis and myelopoiesis, (iii) determine how Spi-B transcriptional activity is regulated in mature B cells, (iv) determine the extent ..
  55. Molecular Aspects of Myeloid Development and Leukemia
    Steven Ackerman; Fiscal Year: 2005 to bring together investigators who have expertise in complementing aspects of stem cell biology and myelopoiesis - from normal myelopoiesis to myeloid leukemias...
    James Downing; Fiscal Year: 1993
    Improved understanding of the regulation of lineage-specific gene expression during myelopoiesis is needed to clarify the fundamental mechanisms controlling normal hematopoietic cell differentiation and to identify therapeutic strategies ..
  57. MSC as facilitators of Transplantion Tolerance
    Amelia Bartholomew; Fiscal Year: 2003
    ..Further, they can provide regulatory signals that inhibit or promote lympho- and myelopoiesis, differentiation, and proliferation and secrete potent molecules, such as TGF-beta, SDF-1, IL-7, and FGF that ..
    Noel Maun; Fiscal Year: 2001
    ..The research goals of this proposal are to establish the role of this gene in myelopoiesis, and to dissect the mechanisms underlying its synergistic regulation by RA and IL3...
    Irving Weissman; Fiscal Year: 2000 to place purified HSC or MPP onto clonal stromal monolayers that permit the development of B lymphocytes and myelopoiesis, either at the bulk level to measure population effects or at the single cell level, to determine whether the ..
    Angel Lee; Fiscal Year: 2004
    ..from the investigator's abstract) Colony-stimulating factor-1(CSF-1) and its receptor, CSF-1R, regulate myelopoiesis, bone remodeling and maturation of the reproductive system, through control of cell growth and apoptosis...
    John Choi; Fiscal Year: 2002
    Hal Broxmeyer; Fiscal Year: 1990
    ..propose to evaluate the separate and combined actions of these molecules in vivo in mice undergoing rebound myelopoiesis, in untreated mice, and in mice infected with the Friend Viruis Complex...
  63. The role of MOZ in normal and leukemic hematopoiesis
    CYNTHIA SNYDER; Fiscal Year: 2007 chromosomal translocations is proposed to interfere with critical hematopoietic signaling pathways, disrupt myelopoiesis, and contribute to the development of acute myeloid leukemia...
  64. Maf Molecular Interactions in Hematopoiesis
    Linda Shapiro; Fiscal Year: 2005
    ..Understanding transcription factor function in myelopoiesis is essential for deciphering the regulation of myeloid cell differentiation...