myelopoiesis

Summary

Summary: Formation of MYELOID CELLS from the pluripotent HEMATOPOIETIC STEM CELLS in the BONE MARROW via MYELOID STEM CELLS. Myelopoiesis generally refers to the production of leukocytes in blood, such as MONOCYTES and GRANULOCYTES. This process also produces precursor cells for MACROPHAGE and DENDRITIC CELLS found in the lymphoid tissue.

Top Publications

  1. ncbi The phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin signaling network and the control of normal myelopoiesis
    Alberto M Martelli
    Department of Human Anatomy, University of Bologna, Bologna, Italy
    Histol Histopathol 25:669-80. 2010
  2. doi The emerging role of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling network in normal myelopoiesis and leukemogenesis
    Alberto M Martelli
    Department of Human Anatomy, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Biochim Biophys Acta 1803:991-1002. 2010
  3. doi Irf8 regulates macrophage versus neutrophil fate during zebrafish primitive myelopoiesis
    Li Li
    State Key Laboratory of Molecular Neuroscience, Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, People s Republic of China
    Blood 117:1359-69. 2011
  4. ncbi A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesis
    Francesco Fazi
    Department of Histology and Medical Embryology, University of Rome La Sapienza and San Raffaele Biomedical Science Park of Rome, Via di Castel Romano 100, 00128, Rome, Italy
    Cell 123:819-31. 2005
  5. ncbi Transcriptional regulation in myelopoiesis: Hematopoietic fate choice, myeloid differentiation, and leukemogenesis
    Alan G Rosmarin
    Department of Medicine, Brown Medical School, Providence, RI, USA
    Exp Hematol 33:131-43. 2005
  6. pmc CREB in the pathophysiology of cancer: implications for targeting transcription factors for cancer therapy
    Kathleen M Sakamoto
    Division of Hematology Oncology, Gwynne Hazen Cherry Memorial Laboratories, Mattel Children s Hospital UCLA, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA
    Clin Cancer Res 15:2583-7. 2009
  7. doi MicroRNAs: key players of normal and malignant myelopoiesis
    Mir Farshid Alemdehy
    Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Curr Opin Hematol 19:261-7. 2012
  8. ncbi Endogenous steroids are responsible for lactoferrin-induced myelopoiesis in mice
    Michał Zimecki
    Laboratory of Immunobiology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, PL 53 114 Wrocław, Poland
    Pharmacol Rep 61:705-10. 2009
  9. pmc Mutant-specific gene programs in the zebrafish
    Gerhard J Weber
    Children s Hospital Stem Cell Program, Department of Hematology Oncology, Howard Hughes Medical Institute, Karp 7, 1 Blackfan Circle, Boston, MA 02115, USA
    Blood 106:521-30. 2005
  10. pmc Transcription of proteinase 3 and related myelopoiesis genes in peripheral blood mononuclear cells of patients with active Wegener's granulomatosis
    Chris Cheadle
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Arthritis Rheum 62:1744-54. 2010

Detail Information

Publications206 found, 100 shown here

  1. ncbi The phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin signaling network and the control of normal myelopoiesis
    Alberto M Martelli
    Department of Human Anatomy, University of Bologna, Bologna, Italy
    Histol Histopathol 25:669-80. 2010
    ..We then further highlight the key role played by the PI3K/Akt/mTOR network during erythropoiesis, megakaryocytopoiesis, and granulo-cytopoiesis/monocytopoiesis...
  2. doi The emerging role of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling network in normal myelopoiesis and leukemogenesis
    Alberto M Martelli
    Department of Human Anatomy, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Biochim Biophys Acta 1803:991-1002. 2010
    ..emanating from the PI3K/Akt/mTOR cascade with the functions of hematopoietic stem cells and the process of myelopoiesis, including lineage commitment...
  3. doi Irf8 regulates macrophage versus neutrophil fate during zebrafish primitive myelopoiesis
    Li Li
    State Key Laboratory of Molecular Neuroscience, Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, People s Republic of China
    Blood 117:1359-69. 2011
    ..One key unresolved question is what factors dictate polymorphonuclear versus mononuclear lineage fates during myelopoiesis. Here we show that during zebrafish embryogenesis interferon regulatory factor-8 (irf8) is expressed ..
  4. ncbi A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesis
    Francesco Fazi
    Department of Histology and Medical Embryology, University of Rome La Sapienza and San Raffaele Biomedical Science Park of Rome, Via di Castel Romano 100, 00128, Rome, Italy
    Cell 123:819-31. 2005
    ..Altogether, our data indicate that miR-223 plays a crucial role during granulopoiesis and point to the NFI-A repression as an important molecular pathway mediating gene reprogramming in this cell lineage...
  5. ncbi Transcriptional regulation in myelopoiesis: Hematopoietic fate choice, myeloid differentiation, and leukemogenesis
    Alan G Rosmarin
    Department of Medicine, Brown Medical School, Providence, RI, USA
    Exp Hematol 33:131-43. 2005
    ..1 and C/EBPalpha contribute directly to development of acute myelogenous leukemia. Thus, normal myeloid development and acute leukemia are now understood to represent opposite sides of the same hematopoietic coin...
  6. pmc CREB in the pathophysiology of cancer: implications for targeting transcription factors for cancer therapy
    Kathleen M Sakamoto
    Division of Hematology Oncology, Gwynne Hazen Cherry Memorial Laboratories, Mattel Children s Hospital UCLA, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA
    Clin Cancer Res 15:2583-7. 2009
    ..Although transcription factors have not been a central focus of drug development, recent advances suggest that CREB and other such proteins may be worthwhile targets for cancer therapy...
  7. doi MicroRNAs: key players of normal and malignant myelopoiesis
    Mir Farshid Alemdehy
    Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Curr Opin Hematol 19:261-7. 2012
    ..The main focus of the article is the function of some evolutionary conserved microRNAs that are abundantly expressed and tightly regulated during myelopoiesis.
  8. ncbi Endogenous steroids are responsible for lactoferrin-induced myelopoiesis in mice
    Michał Zimecki
    Laboratory of Immunobiology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, PL 53 114 Wrocław, Poland
    Pharmacol Rep 61:705-10. 2009
    ..We conclude that LF-induced upregulation of endogenous steroid levels is responsible for the stimulation of myelopoiesis.
  9. pmc Mutant-specific gene programs in the zebrafish
    Gerhard J Weber
    Children s Hospital Stem Cell Program, Department of Hematology Oncology, Howard Hughes Medical Institute, Karp 7, 1 Blackfan Circle, Boston, MA 02115, USA
    Blood 106:521-30. 2005
    ....
  10. pmc Transcription of proteinase 3 and related myelopoiesis genes in peripheral blood mononuclear cells of patients with active Wegener's granulomatosis
    Chris Cheadle
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Arthritis Rheum 62:1744-54. 2010
    ..The aim of this study was to understand the biology underlying WG and to discover markers of disease activity that would be useful for prognosis and treatment guidance...
  11. pmc A myelopoiesis-associated regulatory intergenic noncoding RNA transcript within the human HOXA cluster
    Xueqing Zhang
    Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Blood 113:2526-34. 2009
    ..These findings suggest that HOTAIRM1 plays a role in the myelopoiesis through modulation of gene expression in the HOXA cluster.
  12. doi Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis
    Frederic Pendino
    Department of Molecular Biology, University of Bergen, Bergen, Norway
    Blood 113:3172-81. 2009
    ..RINF expression correlates with retinoid-induced differentiation of leukemic cells and with cytokine-induced myelopoiesis of normal CD34(+) progenitors...
  13. doi Zebrafish granulocyte colony-stimulating factor receptor signaling promotes myelopoiesis and myeloid cell migration
    Clifford Liongue
    School of Medicine, Deakin University, Waurn Ponds, Vic, Australia
    Blood 113:2535-46. 2009
    ..This contrasted with a posterior domain that was largely independent of this pathway. Definitive myelopoiesis was also partially dependent on a functional GCSF/GCSFR pathway...
  14. ncbi Notch signaling requires GATA-2 to inhibit myelopoiesis from embryonic stem cells and primary hemopoietic progenitors
    Renee F de Pooter
    Department of Immunology, University of Toronto, Sunnybrook and Women s Research Institute, 2075 Bayview Avenue, Toronto, Ontario, Canada
    J Immunol 176:5267-75. 2006
    ..that the addition of the Notch ligand Delta-like-1 (Dll-1) to an in vitro system that otherwise supports myelopoiesis, greatly reduces the myelopoietic potential of stem cells or uncommitted progenitors...
  15. pmc Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis
    Linda Yang
    Division of Experimental Hematology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Blood 110:3853-61. 2007
    ..Cdc42 activity is responsive to stimulation by SCF, IL3, SDF-1alpha, and fibronectin. The increased myelopoiesis and decreased erythropoiesis of the knockout mice are associated with an altered gene transcription program in ..
  16. doi The ubiquitin ligase Triad1 inhibits myelopoiesis through UbcH7 and Ubc13 interacting domains
    J A Marteijn
    Central Hematology Laboratory, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Leukemia 23:1480-9. 2009
    ..The differential interaction of the RINGs with Ubcs strongly suggests that the ubiquitination mediated through UbcH7 as well as Ubc13 plays a major role in myelopoiesis.
  17. ncbi Specification of the primitive myeloid precursor pool requires signaling through Alk8 in zebrafish
    Benjamin M Hogan
    Ludwig Institute for Cancer Research, Post Office Box 2008, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    Curr Biol 16:506-11. 2006
    ..We show here that the Bmp receptor lost-a-fin/alk8 is required for rostral pu.1 expression and myelopoiesis, identifying an early genetic event that distinguishes between the induction of anterior and posterior ..
  18. ncbi Epigenetic silencing of the myelopoiesis regulator microRNA-223 by the AML1/ETO oncoprotein
    Francesco Fazi
    Department of Histology and Medical Embryology, University La Sapienza, Rome, 00161, Italy
    Cancer Cell 12:457-66. 2007
    ..myeloid leukemia-associated fusion protein, display low levels of a microRNA-223 (miR-223), a regulator of myelopoiesis. Here, we show that miR-223 is a direct transcriptional target of AML1/ETO...
  19. doi MicroRNAs in normal and malignant myelopoiesis
    Elvira Pelosi
    Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Leuk Res 33:1584-93. 2009
    ..Extensive miRNA deregulation has been observed in leukemia and functional studies support a role for miRNAs in the pathogenesis of these disorders...
  20. pmc Gfi1 regulates miR-21 and miR-196b to control myelopoiesis
    Chinavenmeni S Velu
    Division of Immunobiology, Cincinnati Children s Hospital Medical Center, OH 45244, USA
    Blood 113:4720-8. 2009
    ..Thus, our results not only identify microRNAs whose regulation is required during myelopoiesis, but also provide an example of synergy in microRNA biologic activity and illustrate potential mechanisms ..
  21. pmc FoxP3+ regulatory T cells restrain splenic extramedullary myelopoiesis via suppression of hemopoietic cytokine-producing T cells
    Jee H Lee
    Department of Comparative Pathobiology, Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA
    J Immunol 183:6377-86. 2009
    Extramedullary myelopoiesis occurs in peripheral organs such as spleen and produces many types of myeloid cells with diverse functions in response to inflammation and infection...
  22. pmc Notch-dependent control of myelopoiesis is regulated by fucosylation
    Lan Zhou
    Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    Blood 112:308-19. 2008
    ..and their ligands clearly modulate T lymphopoietic decisions, evidence for their participation in modulating myelopoiesis is much less clear, and roles for posttranslational control of Notch-dependent signal transduction in ..
  23. ncbi Zebrafish as a model for myelopoiesis during embryogenesis
    Jason N Berman
    Department of Pediatric Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Mass 02115, USA
    Exp Hematol 33:997-1006. 2005
    ..The conservation of genes such as scl, pu.1, c/ebpalpha, mpo, l-plastin, and lysozyme C in myelopoiesis and the corresponding expression patterns in zebrafish suggests that shared genetic pathways regulate this ..
  24. pmc The NOTCH pathway contributes to cell fate decision in myelopoiesis
    Laurence Bugeon
    Imperial College London, London, SW7 2AZ, UK
    Haematologica 96:1753-60. 2011
    Controversy persists regarding the role of Notch signaling in myelopoiesis. We have used genetic approaches, employing two Notch zebrafish mutants deadly seven (DES) and beamter (BEA) with disrupted function of notch1a and deltaC, ..
  25. ncbi Loss of gata1 but not gata2 converts erythropoiesis to myelopoiesis in zebrafish embryos
    Jenna L Galloway
    Stem Cell Program and Division of Hematology Oncology, Children s Hospital Boston, Dana Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Dev Cell 8:109-16. 2005
    ..Our studies establish a transcriptional hierarchy of Gata factor dependence during hematopoiesis and demonstrate that gata1 plays an integral role in directing myelo-erythroid lineage fate decisions during embryogenesis...
  26. doi Myelopoiesis in spleen-producing distinct dendritic-like cells
    Jonathan K H Tan
    Research School of Biology, The Australian National University, Canberra, ACT, Australia
    J Cell Mol Med 16:1924-33. 2012
    ..A model is advanced for development of L-DC directly from haematopoietic progenitors in spleen and dependent on the spleen microenvironment...
  27. ncbi Stroma-mediated dysregulation of myelopoiesis in mice lacking I kappa B alpha
    Rudolf A Rupec
    Department of Dermatology, University of Munich, Frauenlobstrasse 9 11, D 80337 Munich, Germany
    Immunity 22:479-91. 2005
    ..In summary, we show that cell-fate decisions leading to a premalignant hematopoietic disorder can be initiated by nonhematopoietic cells with inactive I kappa B alpha...
  28. ncbi Treatment of human bone marrow with recombinant placenta immunoregulator ferritin results in myelopoiesis and T-cell suppression through modulation of the cytokine-chemokine networks
    Chaya Moroz
    Felsenstein Medical Research Center, Rabin Medical Center, Beilinson Campus, Sackler School of Medicine, Tel Aviv University, Petach Tikva, Israel
    Exp Hematol 34:159-66. 2006
    ..The aim of the current study was to investigate the regulatory effects of native placental ferritin (PLF), recombinant PLIF, and C48 on hematopoiesis of human bone marrow (BM)...
  29. ncbi Differential effects of steroids and retinoids on bovine myelopoiesis in vitro
    V Van Merris
    Department of Physiology, Biochemistry and Biometrics, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
    J Dairy Sci 87:1188-95. 2004
    ..Hydrocortisone reduced growth of granulocyte and monocyte colonies, whereas myelopoiesis was not altered by progesterone...
  30. pmc Macrophage activation and differentiation signals regulate schlafen-4 gene expression: evidence for Schlafen-4 as a modulator of myelopoiesis
    Wendy J van Zuylen
    The University of Queensland, Institute for Molecular Bioscience, Queensland, Australia
    PLoS ONE 6:e15723. 2011
    ..Little is known of their function, but previous studies suggest roles in immune cell development. In this report, we assessed Slfn regulation and function in macrophages, which are key cellular regulators of innate immunity...
  31. ncbi Virally mediated MafB transduction induces the monocyte commitment of human CD34+ hematopoietic stem/progenitor cells
    C Gemelli
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
    Cell Death Differ 13:1686-96. 2006
    ..Altogether our data allow to conclude that MafB is a key regulator of human monocytopoiesis...
  32. ncbi Chronic zinc deficiency in mice disrupted T cell lymphopoiesis and erythropoiesis while B cell lymphopoiesis and myelopoiesis were maintained
    Louis E King
    Department of Biochemistry and Molecular Biology, Room 419, Michigan State University, East Lansing, MI 48824 1319, USA
    J Am Coll Nutr 24:494-502. 2005
    The purpose of this study was to determine the impact of chronic zinc deficiency (ChrZD) on T and B cell lymphopoiesis, myelopoiesis and erythropoiesis in mice.
  33. doi MicroRNA control of myelopoiesis and the differentiation block in acute myeloid leukaemia
    Catalina A Palma
    Blood, Stem Cells and Cancer Research, St Vincent s Hospital Centre for Applied Medical Research, St Vincent s Hospital, Darlinghurst, NSW, Australia
    J Cell Mol Med 16:978-87. 2012
    ....
  34. ncbi IL-7 induces myelopoiesis and erythropoiesis
    Francesca B Aiello
    Laboratory of Molecular Immunoregulation, National Cancer Institute, Frederick, MD 21702, USA
    J Immunol 178:1553-63. 2007
    ..were shown to be involved because mice deficient in both GM-CSF and IL-3 also responded to IL-7 with increased myelopoiesis. Candidate cytokines included IFN-gamma and Flt3 ligand, which were also produced in response to IL-7...
  35. doi Expression of myelopoiesis-associated microRNA in bone marrow cells of atypical chronic myeloid leukaemia and chronic myelomonocytic leukaemia
    Kais Hussein
    Institute of Pathology, Hannover Medical School, Carl Neuberg Strasse 1, Hannover, Germany
    Ann Hematol 90:307-13. 2011
    ..b>Myelopoiesis-associated miR-10a, miR-17-5p, miR-155, miR-223 and miR-424 were analysed by real-time polymerase chain ..
  36. pmc Critical roles of lysosomal acid lipase in myelopoiesis
    Peng Qu
    Center for Immunobiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Pathol 176:2394-404. 2010
    ..These results provide evidence that LAL is an important regulator of myelopoiesis during hematopoietic development, differentiation, and homeostasis.
  37. pmc Inositol trisphosphate 3-kinase B (InsP3KB) as a physiological modulator of myelopoiesis
    Yonghui Jia
    Department of Pathology, Dana Farber Harvard Cancer Center, Children s Hospital Boston and Joint Program in Transfusion Medicine, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:4739-44. 2008
    ..Here, we demonstrate that InsP3KB is also a physiological modulator of myelopoiesis. The InsP3KB gene is expressed in all hematopoietic stem/progenitor cell populations...
  38. pmc C/EBPalpha initiates primitive myelopoiesis in pluripotent embryonic cells
    Yaoyao Chen
    Healing Foundation Centre, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
    Blood 114:40-8. 2009
    ..Thus, C/EPBalpha is the first known single factor capable of initiating an entire myelopoiesis pathway in pluripotent cells in the embryo.
  39. pmc Integrated analysis of microRNA and mRNA expression profiles in physiological myelopoiesis: role of hsa-mir-299-5p in CD34+ progenitor cells commitment
    E Tenedini
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
    Cell Death Dis 1:e28. 2010
    ..Gain- and loss-of-function experiments revealed that hsa-miR-299-5p participates in the regulation of hematopoietic progenitor fate, modulating megakaryocytic-granulocytic versus erythroid-monocytic differentiation...
  40. ncbi Transient abnormal myelopoiesis complicated by tumor lysis syndrome
    Yoshifusa Abe
    Division of Neonatology, Chiba Children s Hospital, Chiba, Japan
    Pediatr Int 48:489-92. 2006
  41. ncbi Regulation of myeloid development and function by colony stimulating factors
    Daniel R Barreda
    Department of Biological Sciences, CW 405 Biological Sciences Building, University of Alberta, Edmonton, AB, Canada T6G 2E9
    Dev Comp Immunol 28:509-54. 2004
    ..Although most of available knowledge about CSFs is on human and mouse CSFs, an attempt was made to integrate recent findings in other systems in order to highlight a more widespread role for CSFs throughout evolution...
  42. ncbi Inverse relationship between myeloid maturation and leukotriene C4 synthase expression in normal and leukemic myelopoiesis-consistent overexpression of the enzyme in myeloid cells from patients with chronic myeloid leukemia
    Susanne Tornhamre
    Division of Physiological Chemistry II, Department of Medical Biochemistry and Biophysics, Scheele Laboratory, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Exp Hematol 31:122-30. 2003
    ..The aim of this study was to clarify the expression of LTC(4)S during normal and leukemic myelopoiesis and to investigate the correlation between abnormal LTC(4)S expression in CML myeloid cells and the activity of ..
  43. pmc Infection-induced myelopoiesis during intracellular bacterial infection is critically dependent upon IFN-γ signaling
    Katherine C MacNamara
    Wadsworth Center, New York State Department of Health, Albany, NY 12201, USA
    J Immunol 186:1032-43. 2011
    ..Finally, using mixed bone marrow chimeric mice, we show that IFN-γ-dependent infection-induced myelopoiesis occurs via the direct effect of the cytokine on developing myeloid cells...
  44. doi Regulation of myelopoiesis through syntenin-mediated modulation of IL-5 receptor output
    Jeffrey M Beekman
    Molecular Immunology Laboratory, Department of Immunology, Wilhelmina Childrens Hospital, University Medical Centre Utrecht, Utrecht, The Netherlands
    Blood 114:3917-27. 2009
    ..These data demonstrate that cytokine-specific functions can be transduced by unique receptor alpha-chain-associating adapter proteins...
  45. ncbi Differential regulation of primitive myelopoiesis in the zebrafish by Spi-1/Pu.1 and C/ebp1
    Fengyun Su
    Division of Hematology Oncology and Cellular and Molecular Biology Program, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    Zebrafish 4:187-99. 2007
    ..These data reveal strong functional conservation of pu.1 between zebrafish primitive myelopoiesis and mammalian definitive myelopoiesis...
  46. doi Transcriptional regulation of a myeloid-lineage specific gene lysozyme C during zebrafish myelopoiesis
    Tetsuya Kitaguchi
    HMRO, Kyoto University Faculty of Medicine, Sakyo ku, Kyoto, Japan
    Mech Dev 126:314-23. 2009
    ..lines that drive enhanced green fluorescent protein (EGFP) to examine how lyz expression is regulated during myelopoiesis. We found that the 2.4kb lyz promoter is sufficient to drive myeloid-specific expression of EGFP in zebrafish...
  47. doi EVI1 Impairs myelopoiesis by deregulation of PU.1 function
    Leopoldo Laricchia-Robbio
    Department of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Cancer Res 69:1633-42. 2009
    ..Here, we have examined the expression of several genes activated during terminal myelopoiesis in BM cells and identified a group of them that are altered by EVI1...
  48. pmc Critical roles for IFN-beta in lymphoid development, myelopoiesis, and tumor development: links to tumor necrosis factor alpha
    Raj Deonarain
    Toronto General Research Institute, University Health Network, Toronto, ON, Canada MG5 2M1
    Proc Natl Acad Sci U S A 100:13453-8. 2003
    ..Taken altogether, our data suggest that, in addition to the direct growth-inhibitory effects on tumor cells, IFN-beta is required during different stages of maturation in the development of the immune system...
  49. pmc Genomic expression during human myelopoiesis
    Francesco Ferrari
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Via G, Campi 287, 41100, Modena, Italy
    BMC Genomics 8:264. 2007
    Human myelopoiesis is an exciting biological model for cellular differentiation since it represents a plastic process where multipotent stem cells gradually limit their differentiation potential, generating different precursor cells which ..
  50. ncbi Impaired myelopoiesis in mice devoid of interferon regulatory factor 1
    U Testa
    Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanita, Rome, Italy
    Leukemia 18:1864-71. 2004
    ..These results, together with the fact that IRF-1 is markedly induced early during granulo-monocytic differentiation of CD34+ cells, highlight the pivotal role of IRF-1 in the early phases of myelopoiesis.
  51. ncbi c-FMS chromatin structure and expression in normal and leukaemic myelopoiesis
    George Alexander Follows
    Molecular Medicine Unit, St James s University Hospital, Leeds, UK
    Oncogene 24:3643-51. 2005
    ..element located within the second intron (FIRE - fms intonic regulatory element) during normal and leukaemic myelopoiesis. Granulocytic differentiation from normal and leukaemic precursors is accompanied by loss of transcription ..
  52. ncbi Effect of thermal injury on splenic myelopoiesis
    John G Noel
    Research, Shriners Hospital for Children, 3229 Burnet Avenue, Cincinnati, OH 45229, USA
    Shock 23:115-22. 2005
    ..Our work clearly shows that the increased myelopoiesis observed postinjury leads to the production of mature myeloid cells...
  53. ncbi The effect of steroid on myeloid leukemic cells: the potential of short-course high-dose methylprednisolone treatment in inducing differentiation, apoptosis and in stimulating myelopoiesis
    Gonul Hicsonmez
    Department of Pediatric Hematology, Ihsan Dogramaci Children s Hospital, Faculty of Medicine, Hacettepe University, Ankara 06100, Turkey
    Leuk Res 30:60-8. 2006
    ..We believe that the results of our 17-year clinical experience will provide important benefits to AML patients...
  54. ncbi A novel polysaccharide of black soybean promotes myelopoiesis and reconstitutes bone marrow after 5-flurouracil- and irradiation-induced myelosuppression
    Hui Fen Liao
    Department of Medical Research, Mackay Memorial Hospital, Taipei 251, Taiwan
    Life Sci 77:400-13. 2005
    The aim of this study was to investigate the promotion of myelopoiesis by an active polysaccharide of black soybean (PSBS)...
  55. ncbi Euphorbia tirucalli L. modulates myelopoiesis and enhances the resistance of tumour-bearing mice
    Marize C Valadares
    Departamento de Farmacologia Hemocentro, Faculdade de Ciencias Medicas, FCM, Universidade Estadual de Campinas, UNICAMP, Campinas, SP, Brazil
    Int Immunopharmacol 6:294-9. 2006
    ..Treatment of these animals with Euphorbia tirucalli L. (ET) (125, 250 and 500 mg/kg) stimulated marrow myelopoiesis and reduced spleen colony formation, with no differences observed between the effects of the three doses...
  56. ncbi STAT5-induced self-renewal and impaired myelopoiesis of human hematopoietic stem/progenitor cells involves down-modulation of C/EBPalpha
    Albertus T J Wierenga
    Department of Hematology, University Medical Center Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
    Blood 107:4326-33. 2006
    ..5 (STAT5A) in human cord blood (CB)-derived stem/progenitor cells results in enhanced self-renewal and impaired myelopoiesis. The present study identifies C/EBPalpha as a critical component that is down-regulated by STAT5...
  57. ncbi Deciphering developmental stages of adult myelopoiesis
    Cornelis J Pronk
    Institution for Experimental Medical Science, Immunology Section, Lund University, Lund, Sweden
    Cell Cycle 7:706-13. 2008
    ..When functionally evaluated, such early granulocyte/monocyte precursors displayed a latent lymphoid activity, which was pronounced in subsets bearing high expression of the tyrosine kinase receptor FLT3...
  58. doi Endotoxemia down-regulates bone marrow lymphopoiesis but stimulates myelopoiesis: the effect of G6PD deficiency
    Rachna Chandra
    Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ 07103, USA
    J Leukoc Biol 83:1541-50. 2008
    ..LPS-induced down-regulation of B cell production contributes to the generalized lymphopenia and lymphocyte dysfunction observed following nonspecific immune challenges...
  59. doi Notch signaling in embryonic and adult myelopoiesis
    Ralf Schwanbeck
    Department of Biochemistry, Christian Albrechts Universitat zu Kiel, Kiel, Germany
    Cells Tissues Organs 188:91-102. 2008
    ..components and mechanisms of the Notch signaling pathway and discuss the role of Notch in embryonic and adult myelopoiesis. Finally, we will focus on mediators of Notch signaling in the hematopoietic system...
  60. ncbi Retinoic acid signaling in myelopoiesis
    Karen Drumea
    Warren Alpert Medical School, Brown University, Providence, Rhode Island, USA
    Curr Opin Hematol 15:37-41. 2008
    ..We have not attempted to summarize the related clinical literature...
  61. ncbi p15Ink4b: dual function in myelopoiesis and inactivation in myeloid disease
    Michael Rosu-Myles
    Center for Cancer Research, National Cancer Institute, NIH, Building 37, Room 4124A, 37 Convent Drive MSC 4263, Bethesda, MD 20892 4263, USA
    Blood Cells Mol Dis 40:406-9. 2008
    ..Here we outline the mechanisms by which p15 is silenced and the functions of this CDKI in myelopoiesis as well as discuss the implications of these findings to myeloid disease.
  62. ncbi Protein kinase B (c-akt) regulates hematopoietic lineage choice decisions during myelopoiesis
    Miranda Buitenhuis
    Molecular Immunology Lab, Department of Immunology, University Medical Center, Utrecht, The Netherlands
    Blood 111:112-21. 2008
    ..system was used to investigate the role of PI3K and its downstream effector, protein kinase B (PKB/c-akt) in myelopoiesis. PI3K activity was essential for hematopoietic progenitor survival...
  63. ncbi Four cases of fetal hypoechoic hepatomegaly associated with Trisomy 21 and transient abnormal myelopoiesis
    Akira Kikuchi
    Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Prenat Diagn 27:665-9. 2007
    ..Our objective was to determine the clinical significance of fetal hypoechoic hepatomegaly and serial change of liver sizes...
  64. ncbi Gangliosides of the stroma layer participate in the interferon-gamma receptor-dependent controls of myelopoiesis
    Claudia M B Andrade
    Departamento de Bioquimica, Instituto de Ciências Básicas da Saúde ICBS, Universidade Federal do Rio Grande do Sul UFRGS, Rua Ramiro Barcelos, 2600 Anexo, CEP 90035 003 Porto Alegre, RS, Brazil
    Biochim Biophys Acta 1761:1030-40. 2006
    Stroma-mediated myelopoiesis depends upon growth-factors and an appropriate intercellular microenvironment, whose polarity is relevant for granulocyte-macrophage colony stimulating factor (GM-CSF) mediated myeloid cell proliferation...
  65. ncbi Genetic regulators of myelopoiesis and leukemic signaling identified by gene profiling and linear modeling
    Anna L Brown
    Haematology and Oncology Program, Child Health Research Institute, North Adelaide, South Australia
    J Leukoc Biol 80:433-47. 2006
    ..between proliferation and self-renewal versus growth suppression and differentiation during normal and leukemic myelopoiesis are not understood...
  66. pmc A critical function for B-Raf at multiple stages of myelopoiesis
    Tamihiro Kamata
    Department of Laboratory Medicine, University of California, San Francisco, 513 Parnassus Ave, Room S 577, San Francisco, CA 94143 0100, USA
    Blood 106:833-40. 2005
    ..Together, these data suggest that B-Raf plays a cell-autonomous role in megakaryocytopoiesis and a permissive role in myeloid progenitor development...
  67. ncbi Determinants of lymphoid-myeloid lineage diversification
    Catherine V Laiosa
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Annu Rev Immunol 24:705-38. 2006
    ....
  68. pmc Identification of regulatory functions for 4-1BB and 4-1BBL in myelopoiesis and the development of dendritic cells
    Seung Woo Lee
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    Nat Immunol 9:917-26. 2008
    ..and its ligand 4-1BBL can control adaptive immunity, but here we show that their interaction also suppressed myelopoiesis. We found that 4-1BBL was expressed on hematopoietic stem cells, differentiating common myeloid progenitors and ..
  69. ncbi Cotransplantation of human mesenchymal stem cells enhances human myelopoiesis and megakaryocytopoiesis in NOD/SCID mice
    Maria Angelopoulou
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520 8035, USA
    Exp Hematol 31:413-20. 2003
    ..Because cotransplantation of marrow-derived stromal cells has been shown to enhance engraftment of human hematopoietic stem cells, we hypothesized that cotransplantation of MSC could enhance platelet and myeloid cell development...
  70. ncbi Integrin engagement-induced inhibition of human myelopoiesis is mediated by proline-rich tyrosine kinase 2 gene products
    Scott J Dylla
    Stem Cell Institute and Department of Medicine, University of Minnesota, Minneapolis, Minn, USA
    Exp Hematol 32:365-74. 2004
    ..Here we investigated whether PYK2 gene products mediate integrin signaling in hematopoietic stem and progenitor cells...
  71. ncbi Transcriptional regulators and myelopoiesis: the role of serum response factor and CREB as targets of cytokine signaling
    Patricia Mora-Garcia
    Department of Pediatrics, Division of Hematology Oncology, Mattel Children s Hospital, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Stem Cells 21:123-30. 2003
    ....
  72. ncbi Transgenic expression of stromal cell-derived factor-1/CXC chemokine ligand 12 enhances myeloid progenitor cell survival/antiapoptosis in vitro in response to growth factor withdrawal and enhances myelopoiesis in vivo
    Hal E Broxmeyer
    Department of Microbiology Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Immunol 170:421-9. 2003
    ..with in vitro results, progenitors from SDF-1/CXCL12 transgenic mice displayed enhanced marrow and splenic myelopoiesis: greatly increased progenitor cell cycling and significant increases in progenitor cell numbers...
  73. ncbi Overexpression of murine TSLP impairs lymphopoiesis and myelopoiesis
    Mark J Osborn
    Department of Laboratory Medicine and Pathology, Division of Medical Technology, University of Minnesota, BSBE 6 118, 312 Church Street SE, Minneapolis, MN 55455, USA
    Blood 103:843-51. 2004
    ..Overexpression of TSLP disrupted hematopoietic homeostasis by causing imbalances in lymphopoiesis and myelopoiesis. Mice harboring a TSLP transgene had 5- to 700-fold fewer B and T precursors and no detectable pre-B lymphocyte ..
  74. pmc Enhanced osteoclast development in collagen-induced arthritis in interferon-gamma receptor knock-out mice as related to increased splenic CD11b+ myelopoiesis
    Bert De Klerck
    Laboratory of Immunobiology, Rega Institute, Katholieke Universiteit Leuven, Leuven, Belgium
    Arthritis Res Ther 6:R220-31. 2004
    ..They also provide a plausible explanation for the higher susceptibility of IFN-gammaR KO mice to CIA...
  75. pmc Apoptosis role of FAS/FAS ligand system in the regulation of myelopoiesis
    Faris Q Alenzi
    Department of Medical Laboratory Sciences, College of Applied Medical Sciences, King Faisal University, Dammam, Saudi Arabia
    Yale J Biol Med 78:25-36. 2005
    CD34+ cells and colony forming unit-granulocyte and macrophage (CFU-GM) from human bone marrow were used to investigate the role of Fas/FasL system in the regulation of myelopoiesis.
  76. ncbi The death-associated protein kinase 2 is up-regulated during normal myeloid differentiation and enhances neutrophil maturation in myeloid leukemic cells
    Mattia Rizzi
    Experimental Oncology Hematology, University of Bern, Murtenstrasse 35, 3010 Bern, Switzerland
    J Leukoc Biol 81:1599-608. 2007
    ..In summary, our findings implicate a role for DAPK2 in granulocyte maturation...
  77. ncbi Efficient ex vivo expansion of NOD/SCID-repopulating cells with lympho-myeloid potential in hematopoietic grafts of children with solid tumors
    C Tourino
    Departamento Basico de Medicina, Hospital de Clinicas, Montevideo, Uruguay
    Hematol J 2:108-16. 2001
    ....
  78. ncbi Constitutive activation of Flt3 and STAT5A enhances self-renewal and alters differentiation of hematopoietic stem cells
    Malcolm A S Moore
    Moore Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Exp Hematol 35:105-16. 2007
    ..To model human leukemogenesis by transduction of human hematopoietic stem cells (HSC) with genes associated with leukemia and expressed in leukemic stem cells...
  79. ncbi Key role of flt3 ligand in regulation of the common lymphoid progenitor but not in maintenance of the hematopoietic stem cell pool
    Ewa Sitnicka
    Department of Stem Cell Biology, Institute of Laboratory Medicine, University Hospital of Lund, BMC, B12, Klinikgatan 26, 221 84 Lund, Sweden
    Immunity 17:463-72. 2002
    ..Noteworthy, CLP express high levels of both the flt3 receptor and ligand, indicating a potential autocrine role of FL in regulation of the earliest lymphoid commitment step from HSC...
  80. ncbi Signaling pathways implicated in hematopoietic progenitor cell proliferation and differentiation
    Diana Bugarski
    The Institute for Medical Research, Dr Subotica 4, 11129 Beograd, Serbia and Montenegro
    Exp Biol Med (Maywood) 232:156-63. 2007
    ....
  81. ncbi Inflammatory biomarker, neopterin, suppresses B lymphopoiesis for possible facilitation of granulocyte responses, which is severely altered in age-related stromal-cell-impaired mice, SCI/SAM
    Akihiro Minami
    Department of Anatomy, Nihon University School of Medicine, 30 1 Ohyaguchi kamimachi, Tokyo, Japan
    Exp Biol Med (Maywood) 232:134-45. 2007
    ....
  82. ncbi Down-regulation of RXRalpha expression is essential for neutrophil development from granulocyte/monocyte progenitors
    Sabine Taschner
    Institute of Immunology, Medical University Vienna, Austria
    Blood 109:971-9. 2007
    ..transcription factors that play key roles in cellular proliferation and differentiation processes including myelopoiesis. Retinoid X receptor alpha (RXRalpha) represents the predominant NR types I and II homo- and heterodimerization ..
  83. ncbi Zinc deficiency in mice alters myelopoiesis and hematopoiesis
    Louis E King
    Department of Biochemistry and Molecular Biology and Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI 48824 1319, USA
    J Nutr 132:3301-7. 2002
    ..severely zinc-deficient (ZD) young adult mice whose bone marrow was evaluated for alterations in hematopoiesis, myelopoiesis and lymphopoiesis by flow cytometry...
  84. ncbi Gene expression analysis of myeloid and lymphoid lineage markers during mouse haematopoiesis
    E Sakhinia
    Division of Laboratory and Regenerative Medicine, School of Medicine, Faculty of Medical and Human Sciences, The University of Manchester, Manchester, UK
    Br J Haematol 135:105-16. 2006
    ..In addition to providing baseline values for myeloid and lymphoid lineage markers during mouse haematopoiesis, these results highlight the importance of single-cell analysis in the study of complex tissues...
  85. ncbi Adult murine hematopoiesis can proceed without beta1 and beta7 integrins
    Gerd Bungartz
    Max Planck Institute of Biochemistry, Department of Molecular Medicine, Am Klopferspitz 18, 82152 Martinsried, Germany
    Blood 108:1857-64. 2006
    ..These data show that alpha4beta1 and alpha4beta7 are not required for blood cell differentiation, although in their absence alterations in numbers and distribution of progenitor cells were observed...
  86. ncbi Hematopoietic cells from gadd45a-deficient and gadd45b-deficient mice exhibit impaired stress responses to acute stimulation with cytokines, myeloablation and inflammation
    S K Gupta
    Department of Biochemistry, Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19104, USA
    Oncogene 25:5537-46. 2006
    ..These findings should aid in understanding the response of normal and malignant hematopoietic cells to physiological and chemical stressors including anticancer agents...
  87. ncbi Mice lacking three myeloid colony-stimulating factors (G-CSF, GM-CSF, and M-CSF) still produce macrophages and granulocytes and mount an inflammatory response in a sterile model of peritonitis
    Margaret L Hibbs
    Signal Transduction Laboratory, Ludwig Institute for Cancer Research, Melbourne Tumour Biology Branch, Royal Melbourne Hospital, Victoria, and Department of Medicine, University of Melbourne, Parkville, Australia
    J Immunol 178:6435-43. 2007
    ..These data establish that in the absence of G-CSF, GM-CSF, and M-CSF, additional growth factor(s) can stimulate myelopoiesis and acute inflammatory responses.
  88. ncbi Delineation of the earliest lineage commitment steps of haematopoietic stem cells: new developments, controversies and major challenges
    Natalija Buza-Vidas
    Haematopoietic Stem Cell Laboratory, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Headington, Oxford, UK
    Curr Opin Hematol 14:315-21. 2007
    ..This review addresses recently reported evidence for alternative cellular pathways for haematopoietic stem cell lineage commitment...
  89. ncbi Genomic and proteomic analysis of the myeloid differentiation program: global analysis of gene expression during induced differentiation in the MPRO cell line
    Zheng Lian
    Department of Genetics, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT, USA
    Blood 100:3209-20. 2002
    ..Data are available online at http://bioinfo.mbb.yale.edu/expression/myelopoiesis.
  90. pmc Maximal STAT5-induced proliferation and self-renewal at intermediate STAT5 activity levels
    Albertus T J Wierenga
    University Medical Center Groningen, University of Groningen, Department of Hematology, Groningen, The Netherlands
    Mol Cell Biol 28:6668-80. 2008
    ..Induction of STAT5A activity in CD34(+) cells resulted in impaired myelopoiesis and induction of erythropoiesis, which was most pronounced at the highest STAT5A transactivation levels...
  91. doi Differentiation and characterization of myeloid cells
    Peter Gaines
    Yale University School of Medicine, New Haven, Connecticut, USA
    Curr Protoc Immunol . 2005
    Recent molecular studies of myeloid differentiation have utilized several in vitro models of myelopoiesis. Hematopoietic progenitors expressing the CD34+ antigen can be induced in vitro in a process that recapitulates the normal myeloid ..
  92. doi Myeloprotection following cytotoxic damage: the sooner the better
    Francis Herodin
    Exp Hematol 36:769-70; author reply 771-2. 2008
  93. pmc Kruppel-like factor 4 is essential for inflammatory monocyte differentiation in vivo
    Jonathan K Alder
    Divisions of Immunology and Hematopoiesis, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    J Immunol 180:5645-52. 2008
    ....
  94. pmc Knock-in of an internal tandem duplication mutation into murine FLT3 confers myeloproliferative disease in a mouse model
    Li Li
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Blood 111:3849-58. 2008
    ..It also appears to suppress B lymphoid maturation. Additional cooperative events appear to be required to progress to acute leukemia...
  95. ncbi Requirement of N-myristoyltransferase 1 in the development of monocytic lineage
    Anuraag Shrivastav
    Department of Pathology, College of Medicine, University of Saskatchewan, Canada
    J Immunol 180:1019-28. 2008
    ..We report in this study novel observation that regulated total NMT activity and NMT1 is essential for proper monocytic differentiation of the mouse bone marrow cells...
  96. ncbi Overexpression of stem cell associated ALDH1A1, a target of the leukemogenic transcription factor TLX1/HOX11, inhibits lymphopoiesis and promotes myelopoiesis in murine hematopoietic progenitors
    Kim L Rice
    School of Veterinary and Biomedical Sciences, Division of Health Sciences, Murdoch University, South Street, Murdoch, Perth WA 6150, Australia
    Leuk Res 32:873-83. 2008
    ....
  97. ncbi Notch1 activation reduces proliferation in the multipotent hematopoietic progenitor cell line FDCP-mix through a p53-dependent pathway but Notch1 effects on myeloid and erythroid differentiation are independent of p53
    K Henning
    Department of Biochemistry, Christian Albrechts University of Kiel, Olshausenstrasse 40, Kiel, Germany
    Cell Death Differ 15:398-407. 2008
    ..These data suggest that Notch signaling triggers two distinct pathways, a p53-dependent one leading to a block in proliferation and a p53-independent one promoting differentiation...
  98. ncbi CD44-mediated hematopoietic progenitor cell adhesion and its complex role in myelopoiesis
    Andres Hidalgo
    Centro de Investigaciones Biologicas, Department of Immunology, Velazquez 144, 28006 Madrid, Spain
    J Hematother Stem Cell Res 11:539-47. 2002
    ..Instead, IM7.8.1 completely blocked myelopoiesis, whereas an anti-alpha 4 integrin mAb increased CFU-GM amounts...
  99. pmc FLT3-ITD cooperates with inv(16) to promote progression to acute myeloid leukemia
    Hyung Gyoon Kim
    Department of Microbiology, Division of Developmental and Clinical Immunology, University of Alabama at Birmingham, Birmingham, AL 35294 2182, USA
    Blood 111:1567-74. 2008
    ..These results indicate that FLT3-activating mutations can cooperate with CBFbeta-SMMHC in an animal model of inv(16)-associated AML...
  100. pmc Efficacy of delayed administration of post-chemotherapy granulocyte colony-stimulating factor: evidence from murine studies of bone marrow cell kinetics
    Maxim Yankelevich
    Texas Children s Cancer Center, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, USA
    Exp Hematol 36:9-16. 2008
    ..Given the high cost of G-CSF prophylaxis, its delayed administration may potentially result in substantial economic benefits...
  101. ncbi NF-E2-mediated enhancement of megakaryocytic differentiation and platelet production in vitro and in vivo
    Ee ling Fock
    Centre for Vascular Research, Department of Medicine, St George Clinical School, University of New South Wales, Sydney, Australia
    Exp Hematol 36:78-92. 2008
    ..By overexpressing the p45 subunit of NF-E2, we aim to increase the proportion of mature MKs and the potential for platelet production in vitro and in vivo...

Research Grants78

  1. CDP/CUT AND MYELOID DIFFERENTIATION
    Nancy Berliner; Fiscal Year: 2001
    ..to further characterize the interaction of CDP and C/EBP in regulating stage specific gene expression during myelopoiesis. We will also determine the role of CDP and C/EBPa in abnormal states characterized by global failure of ..
  2. NEUROFIBROMATOSIS TYPE 1 GENE REGULATES MYELOPOIESIS
    DAVID CLAPP; Fiscal Year: 2006
    ..abstract_text> ..
  3. A TRANSCRIPTIONAL PROGRAM REGULATING MYELOPOIESIS
    Alan Friedman; Fiscal Year: 2004
    ..C/EBPalpha (C/EBPa) and PU.1 are key regulators of myelopoiesis. C/EBPa null mice lack granulocytes, and PU.1 null mice lack B cells, granulocytes, and monocytes...
  4. Synthetic Lethal Targeting of p53 in Myelodysplasia
    A Look; Fiscal Year: 2007
    ..seeks to fill this gap by exploiting the zebrafish experimental system, which affords a faithful model of human myelopoiesis and is uniquely suited to identify critical pathways, using 1) large-scale forward genetic screens and 2) rapid ..
  5. Synthetic Lethal Targeting of p53 in Myelodysplasia
    A Look; Fiscal Year: 2009
    ..seeks to fill this gap by exploiting the zebrafish experimental system, which affords a faithful model of human myelopoiesis and is uniquely suited to identify critical pathways, using 1) large-scale forward genetic screens and 2) rapid ..
  6. Synthetic Lethal Targeting of p53 in Myelodysplasia
    A Thomas Look; Fiscal Year: 2010
    ..seeks to fill this gap by exploiting the zebrafish experimental system, which affords a faithful model of human myelopoiesis and is uniquely suited to identify critical pathways, using 1) large-scale forward genetic screens and 2) rapid ..
  7. MYELOPOIETIC STIMULATION FOLLOWING BURN INJURY
    Richard Gamelli; Fiscal Year: 2007
    ..Our group has demonstrated a significant role for bone marrow myelopoiesis (a developmental program that is responsible for the continuous production of many leukocytes) in the ..
  8. Genetic Basis of Myeloid Neoplasia--Mutagenesis Screens
    A Look; Fiscal Year: 2005
    ..a deficiency or abnormal distribution of circulating granulocytes, implicating genes important in vertebrate myelopoiesis; and (Ii) a subset of the genes discovered by this method will have human counterparts that contribute to ..
  9. NEUROFIBROMATOSIS TYPE 1 GENE REGULATES MYELOPOIESIS
    DAVID W CLAPP; Fiscal Year: 2010
    ..If the hypothesis is correct, we would predict that developing small molecules that inhibit Pak1 function could be useful as a molecular therapy for treatment of plexiform neurofibromas. ..
  10. CYTOKINE REGULATION OF HUMAN EOSINOPHIL GENES
    Steven Ackerman; Fiscal Year: 2006
    ..basic protein (MBP) genes as models for defining the eosinophil developmental program in the general context of myelopoiesis. Three specific questions (aims) are proposed: (1) What are the transcription factors, their interactions and ..
  11. Signal Transduction by Cytokine Receptors in Vivo
    Warner Greene; Fiscal Year: 2004
    ..profiling and analysis of genetically modified mouse lines will establish whether specific contributions to myelopoiesis in vivo can be assigned to singular gene targets of this receptor...
  12. Signal Transduction by Cytokine Receptors in Vivo
    MARK GOLDSMITH; Fiscal Year: 2001
    ..profiling and analysis of genetically modified mouse lines will establish whether specific contributions to myelopoiesis in vivo can be assigned to singular gene targets of this receptor...
  13. MYELOPOIETIC STIMULATION FOLLOWING BURN INJURY
    Richard Gamelli; Fiscal Year: 2002
    ..In the third aim, we will determine if abrogation of the immunosuppressive and myelopoiesis regulating prostanoid, PGE2, can normalize monocytopoiesis, c-fms expression, PU...
  14. DIETARY ZINC-ITS EFFECTS ON THE IMMUNE RESPONSE
    Pamela Fraker; Fiscal Year: 2007
    ..We also suspect phenotypic analysis of progenitor cells in ZD mice will show they are also skewed towards myelopoiesis. 2...
  15. Targeted Therapy of Lyn in Myelodysplastic Syndrome
    SETH JOEL COREY; Fiscal Year: 2010
    ..Therefore, we hypothesize that disordered myelopoiesis due to dysfunctional G-CSF Receptor signaling underlies some cases of MDS and that targeted therapy may ..
  16. Targeted Therapy of Lyn in Myelodysplastic Syndrome
    Seth Corey; Fiscal Year: 2007
    ..Therefore, we hypothesize that disordered myelopoiesis due to dysfunctional G-CSF Receptor signaling underlies some cases of MDS and that targeted therapy may ..
  17. Targeted Therapy of Lyn in Myelodysplastic Syndrome
    Seth Corey; Fiscal Year: 2006
    ..Therefore, we hypothesize that disordered myelopoiesis due to dysfunctional G-CSF Receptor signaling underlies some cases of MDS and that targeted therapy may ..