erythrocyte aging

Summary

Summary: The senescence of RED BLOOD CELLS. Lacking the organelles that make protein synthesis possible, the mature erythrocyte is incapable of self-repair, reproduction, and carrying out certain functions performed by other cells. This limits the average life span of an erythrocyte to 120 days.

Top Publications

  1. ncbi Storage-related changes in erythrocyte band 3: not a case for the Diego blood group antigens
    G J C G M Bosman
    Department of Biochemistry, University Medical Centre Nijmegen, NL 6500 HB Nijmegen, The Netherlands
    Cell Mol Biol (Noisy-le-grand) 51:195-200. 2005
  2. pmc Quantitative analysis of mechanisms that govern red blood cell age structure and dynamics during anaemia
    Nicholas J Savill
    Centre for Infectious Diseases, Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Comput Biol 5:e1000416. 2009
  3. ncbi Comparative proteomics of erythrocyte aging in vivo and in vitro
    G J C G M Bosman
    Department of Biochemistry, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, The Netherlands
    J Proteomics 73:396-402. 2010
  4. ncbi Red blood cell senescence and neocytolysis in humans after high altitude acclimatization
    Angela Risso
    M A T I Microgravity, Aging, Training, Immobility Centre of Excellence, University of Udine, P le M Kolbe 4, I 33100 Udine, Italy
    Blood Cells Mol Dis 38:83-92. 2007
  5. pmc Effects of erythrocyte aging on nitric oxide and nitrite metabolism
    Benjamin Y Owusu
    Department of Pathology and Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, Alabama
    Antioxid Redox Signal 19:1198-208. 2013
  6. ncbi Erythrocyte aging and malaria
    I W Sherman
    Department of Biology, University of California, Riverside, CA 92521, USA
    Cell Mol Biol (Noisy-le-grand) 50:159-69. 2004
  7. ncbi Accelerated senescence of human erythrocytes cultured with Plasmodium falciparum
    Fausta Omodeo-Salè
    Istituto di Fisiologia Generale e Chimica Biologica Giovanni Esposito, Facolta di Farmacia, Via Trentacoste 2, 20134 Milano, Italy
    Blood 102:705-11. 2003
  8. ncbi Acidic and neutral sialidase in the erythrocyte membrane of type 2 diabetic patients
    Bruno Venerando
    Department of Medical Chemistry and Biochemistry, School of Medicine, University of Milan, LITA, Via Fratelli Cervi, 93 20090 Segrate, Milan, Italy
    Blood 99:1064-70. 2002
  9. ncbi Senescent erythrocytes: modification of rheologic properties, antigenic expression and interaction with monocytes
    A Racca
    Laboratorio Inmunohematología, Hemorreología e Inmunogenética, Facultad de Ciencias Bioquimicas y Farmaceuticas, Universidad Nacional de Rosario, Argentina
    Medicina (B Aires) 59:33-7. 1999
  10. ncbi The mechanism of loss of CR1 during maturation of erythrocytes is different between factor I deficient patients and healthy donors
    Sylvie Miot
    Department of Research, University Hospital Basel, Basel, Switzerland
    Blood Cells Mol Dis 29:200-12. 2002

Research Grants

Detail Information

Publications165 found, 100 shown here

  1. ncbi Storage-related changes in erythrocyte band 3: not a case for the Diego blood group antigens
    G J C G M Bosman
    Department of Biochemistry, University Medical Centre Nijmegen, NL 6500 HB Nijmegen, The Netherlands
    Cell Mol Biol (Noisy-le-grand) 51:195-200. 2005
    ..This makes it unlikely that immunological removal of erythrocytes after transfusion is mediated by reactions involving the Diego blood group system...
  2. pmc Quantitative analysis of mechanisms that govern red blood cell age structure and dynamics during anaemia
    Nicholas J Savill
    Centre for Infectious Diseases, Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Comput Biol 5:e1000416. 2009
    ..We also provide evidence of large diurnal oscillations in serum erythropoietin levels during anaemia...
  3. ncbi Comparative proteomics of erythrocyte aging in vivo and in vitro
    G J C G M Bosman
    Department of Biochemistry, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, The Netherlands
    J Proteomics 73:396-402. 2010
    ..maintain erythrocyte homeostasis; (2) open new roads to elucidate the processes that regulate physiological erythrocyte aging and removal, and thereby; (3) provide the foundation for rational interventions to prevent untimely ..
  4. ncbi Red blood cell senescence and neocytolysis in humans after high altitude acclimatization
    Angela Risso
    M A T I Microgravity, Aging, Training, Immobility Centre of Excellence, University of Udine, P le M Kolbe 4, I 33100 Udine, Italy
    Blood Cells Mol Dis 38:83-92. 2007
    ..50% (+/-7) to 97.90% (+/-2.00)). Furthermore, the remaining young and middle-aged RBCs had acquired a senescent-like phenotype, which may account for their increased susceptibility to phagocytosis...
  5. pmc Effects of erythrocyte aging on nitric oxide and nitrite metabolism
    Benjamin Y Owusu
    Department of Pathology and Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, Alabama
    Antioxid Redox Signal 19:1198-208. 2013
    ..We tested the hypothesis that distinct RBC populations will have differential effects on NO signaling...
  6. ncbi Erythrocyte aging and malaria
    I W Sherman
    Department of Biology, University of California, Riverside, CA 92521, USA
    Cell Mol Biol (Noisy-le-grand) 50:159-69. 2004
    ..Despite these parasite-induced age effects P. falciparum is able to avoid destruction by splenic removal through microvessel sequestration in the deep tissues via PS, clustered band 3 protein and adhesive neoantigens...
  7. ncbi Accelerated senescence of human erythrocytes cultured with Plasmodium falciparum
    Fausta Omodeo-Salè
    Istituto di Fisiologia Generale e Chimica Biologica Giovanni Esposito, Facolta di Farmacia, Via Trentacoste 2, 20134 Milano, Italy
    Blood 102:705-11. 2003
    ..In summary, we demonstrated that membrane damage leading to accelerated senescence of both infected and uninfected erythrocytes will likely contribute to malaria anemia...
  8. ncbi Acidic and neutral sialidase in the erythrocyte membrane of type 2 diabetic patients
    Bruno Venerando
    Department of Medical Chemistry and Biochemistry, School of Medicine, University of Milan, LITA, Via Fratelli Cervi, 93 20090 Segrate, Milan, Italy
    Blood 99:1064-70. 2002
    ..It has been suggested that the expression of the neutral enzyme requires some activation mechanism that is impaired in diabetes...
  9. ncbi Senescent erythrocytes: modification of rheologic properties, antigenic expression and interaction with monocytes
    A Racca
    Laboratorio Inmunohematología, Hemorreología e Inmunogenética, Facultad de Ciencias Bioquimicas y Farmaceuticas, Universidad Nacional de Rosario, Argentina
    Medicina (B Aires) 59:33-7. 1999
    ..01). The significant modifications in the biomechanic properties of senescent red blood cell membrane and the loss of antigenic expression could lead to physiological phagocytosis...
  10. ncbi The mechanism of loss of CR1 during maturation of erythrocytes is different between factor I deficient patients and healthy donors
    Sylvie Miot
    Department of Research, University Hospital Basel, Basel, Switzerland
    Blood Cells Mol Dis 29:200-12. 2002
    ..These data suggest that cell surface domains rich in CR1, but not in DAF, are specifically lost in factor I deficiency...
  11. ncbi A detailed study of time-dependent changes in human red blood cells: from reticulocyte maturation to erythrocyte senescence
    Sean C Gifford
    Visual and Circulatory Biophysics Laboratory, Department of Biomedical Engineering, Boston University, Boston, MA, USA
    Br J Haematol 135:395-404. 2006
    ..15%) and a model describing the complete time-course of diminishing mean RBC area and Hb is proposed. The relationship between the losses of Hb and area, and their possible influence on red cell lifespan, are discussed...
  12. ncbi Erythrocyte aging: a more than superficial resemblance to apoptosis?
    Giel J C G M Bosman
    Department of Biochemistry, Radboud University Nijmegen Medical Center, Nijmegen Center for Molecular Life Sciences, Nijmegen, The Netherlands
    Cell Physiol Biochem 16:1-8. 2005
    In physiological circumstances, erythrocyte aging leads to binding of autologous IgG followed by recognition and removal through phagocytosis, mainly by Kupffer cells in the liver...
  13. ncbi Band 3/complement-mediated recognition and removal of normally senescent and pathological human erythrocytes
    Paolo Arese
    Department of Genetics, Biology and Biochemistry, University of Torino Medical School, Torino
    Cell Physiol Biochem 16:133-46. 2005
    ..falciparum malaria, may lead to massive and rapid destruction of RBCs by a mechanism comparable to a dramatic, time-compressed enhancement of normal RBC senescence...
  14. ncbi Complement-mediated clearance of erythrocytes: mechanism and delineation of the regulatory roles of Crry and DAF. Decay-accelerating factor
    Hector Molina
    Center for Experimental Therapeutics, Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Blood 100:4544-9. 2002
    ..These results shed new light on the relative activities of Crry and DAF and underscore the critical roles of membrane C3 regulators in preventing spontaneous and antibody-induced erythrocyte damage in vivo...
  15. ncbi Erythrocyte vesiculation: a self-protective mechanism?
    Frans L A Willekens
    Department of Clinical Chemistry, Rijnstate Hospital, Arnhem, The Netherlands
    Br J Haematol 141:549-56. 2008
    ..Consequently, these same removal molecules mediate the rapid removal of erythrocyte-derived vesicles from the circulation...
  16. ncbi Erythrocyte aging in neurodegenerative disorders
    L de Franceschi
    Department of Clinical and Experimental Medicine, Section of Internal Medicine, University of Verona, Policlinico GB Rossi, P le L Scuro 10, 37134 Verona, Italy
    Cell Mol Biol (Noisy-le-grand) 50:179-85. 2004
    ..We have reviewed the mechanism(s) of the loss of red cell membrane stability and of the precocious red cell aging in neurodegenerative disorders...
  17. ncbi Phosphotyrosine phosphatases acting on band 3 in human erythrocytes of different age: PTP1B processing during cell ageing
    Annarita Ciana
    Universita di Pavia, Dipartimento di Biochimica A Castellani, Sezione di Scienze, via Bassi, 21, 27100 Pavia, Italy
    Bioelectrochemistry 62:169-73. 2004
    ....
  18. ncbi Increased release of free Fe ions in human erythrocytes during aging in the circulation
    Ken Ando
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    Free Radic Res 36:1079-84. 2002
    ..The results indicated that free Fe ions were released from erythrocytes during aging process in the circulation. Released free Fe ions would promote oxidative damages of the cells during aging process...
  19. ncbi Experiences in the measurement of RBC-bound IgG as markers of cell age
    Renata Paleari
    Dipartimento di Scienze e Tecnologie Biomediche, Universita degli Studi di Milano, Via Fratelli Cervi 93, 20090 Segrate, Milan, Italy
    Bioelectrochemistry 62:175-9. 2004
    ..A significantly greater number of RBC-bound IgG was measured in splenectomized beta-thalassemia intermedia patients and in subjects with secondary decreases in the C3 complement fraction concentration...
  20. ncbi The red cell revisited--matters of life and death
    J M Werre
    Department of Blood Transfusion and Transplantation Immunology, University Medical Center, Nijmegen, The Netherlands
    Cell Mol Biol (Noisy-le-grand) 50:139-45. 2004
    ..Removal of old erythrocytes from the circulation and from donor blood may open new ways into the treatment of both bilirubin and secondary iron overload...
  21. ncbi Oxygen transport in blood at high altitude: role of the hemoglobin-oxygen affinity and impact of the phenomena related to hemoglobin allosterism and red cell function
    Michele Samaja
    Dipartimento di Medicina, Chirurgia e Odontoiatria, Ospedale San Paolo, Universita di Milano, Via di Rudini 8, 20142 Milan, Italy
    Eur J Appl Physiol 90:351-9. 2003
    ....
  22. ncbi Time course of the age-related alterations in stored blood
    Sibel Türkes
    Physics Engineering Department, Faculty of Engineering, Hacettepe University, Beytepe, Ankara 06532, Turkey
    Biophys Chem 105:143-50. 2003
    ..Two exponential curves attributed to the liquid and cellular parts of a given samples were found to be described best in the reduction of MAL-6 spin label in WB, AE and AAE...
  23. ncbi Molecular and cellular mechanisms of erythrocyte programmed cell death: impact on blood transfusion
    D Bratosin
    National Institute of Biological Science Research and Development, Bucarest, Rumania
    Vox Sang 83:307-10. 2002
  24. ncbi Phosphatidylserine externalization in sickle red blood cells: associations with cell age, density, and hemoglobin F
    Zahida Yasin
    Vontz Center for Molecular Studies, Hematology Oncology Division ML 0508, Department of Internal Medicine, University of Cincinnati College of Medicine, 3125 Eden Avenue, Cincinnati, OH, USA
    Blood 102:365-70. 2003
    ..These studies indicate that PS externalization in sickle cells may be low level, as observed in many immature cells, or high level, which is associated with dehydration and appears to be more specific for sickle RBCs...
  25. ncbi Hydrogen-peroxide-induced heme degradation in red blood cells: the protective roles of catalase and glutathione peroxidase
    Enika Nagababu
    Molecular Dynamics Section, Gerontology Research Center, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Biochim Biophys Acta 1620:211-7. 2003
    ..The unique role of GSHPX is attributed to its ability to react with hydrogen peroxide generated in close proximity to the red cell membrane in conjunction with the autoxidation of membrane-bound hemoglobin...
  26. ncbi Splenectomy prolongs in vivo survival of erythrocytes differently in spectrin/ankyrin- and band 3-deficient hereditary spherocytosis
    Ramune Reliene
    Institute of Biochemistry, Swiss Federal Institute of Technology, ETH Hönggerberg HPM D14 2, CH 8093 Zurich, Switzerland
    Blood 100:2208-15. 2002
    ....
  27. ncbi Production of pathogen-inactivated RBC concentrates using PEN110 chemistry: a Phase I clinical study
    James P AuBuchon
    Cell Labeling Laboratory, Department of Pathology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, USA
    Transfusion 42:146-52. 2002
    ..Despite extensive reductions in risk, donor selection and testing cannot eliminate pathogen transmission. The objective of this study was to evaluate clinically the viability of pathogen-inactivated RBCs...
  28. ncbi Mapping of senescent cell antigen on brain anion exchanger protein (AE) isoforms using HPLC and fast atom bombardment ionization mass spectrometry (FAB-MS)
    Marguerite M Kay
    International Foundation for Biomedical Aging Research, PO Box 1887, Temple, TX 76503 1887, USA
    J Mol Recognit 17:33-40. 2004
    ..This provides confirmation that SCA is on non-erythroid cell types. Implications of these studies to the generation of neoantigens by oxidation and their recognition by autoantibodies to them are discussed...
  29. ncbi The in vitro quality of washed, prestorage leucocyte-depleted red blood cell concentrates
    V Weisbach
    Department of Transfusion Medicine and Haemostaseology, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen, Germany
    Vox Sang 87:19-26. 2004
    ..No data are currently available on the quality of washed prestorage leucocyte-depleted red blood cell concentrates (RCCs)...
  30. ncbi The 24-hour posttransfusion survival of baboon red blood cells preserved in citrate phosphate dextrose/ ADSOL (CPD/AS-1) for 49 days
    C Robert Valeri
    Naval Blood Research Laboratory, Boston University School of Medicine, 615 Albany Street, Boston, Massachusetts 02118, USA
    Contemp Top Lab Anim Sci 44:38-40. 2005
    ..Further storage for 42 and 49 days resulted in lower values for baboon RBCs compared with human RBCs...
  31. ncbi [Erythrophagocytosis and recycling of heme iron in normal and pathological conditions; regulation by hepcidin]
    C Beaumont
    Inserm U656, Faculte Xavier Bichat, Paris
    Transfus Clin Biol 12:123-30. 2005
    ..Perturbations in erythrophagocytosis play a physiopathological role in several diseases, including hemochromatosis, anemia of chronic disorders and thalassemia...
  32. ncbi Iron homeostasis in chronic inflammation
    J Balla
    Department of Medicine, Division of Nephrology and Hemodialysis Unit, Medical and Health Science Center, University of Debrecen, Nagyerdei krt 98, H 4012 Debercen, Hungary
    Acta Physiol Hung 94:95-106. 2007
    ..The present review concerns the underlying alterations in iron metabolism induced by chronic inflammation that result in anemia...
  33. pmc Effects of age-dependent membrane transport changes on the homeostasis of senescent human red blood cells
    Virgilio L Lew
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom
    Blood 110:1334-42. 2007
    ..Based on these observations, a working hypothesis is proposed to explain the mechanism of progressive RBC densification with age and of the late reversal to a low-density condition with altered ionic gradients...
  34. pmc Tank-tread frequency of the red cell membrane: dependence on the viscosity of the suspending medium
    Thomas M Fischer
    Institut fur Physiologie, Medizinische Fakultät der Rheinisch Westfälischen Technischen Hochschule Aachen, Aachen, Germany
    Biophys J 93:2553-61. 2007
    ..A fit of the data collected in this work to a theoretical red cell model might allow one to determine intrinsic mechanical constants in the low deformation regime...
  35. ncbi Storage-dependent remodeling of the red blood cell membrane is associated with increased immunoglobulin G binding, lipid raft rearrangement, and caspase activation
    Anastasios G Kriebardis
    Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis, Greece
    Transfusion 47:1212-20. 2007
    ..The membrane hosts critical steps in these mechanisms and undergoes widespread remodeling over the storage period...
  36. ncbi Albumin-quercetin combination offers a therapeutic advantage in the prevention of reduced survival of erythrocytes in visceral leishmaniasis
    Gargi Sen
    Indian Association for Cultivation of Science, Kolkata 700032, India
    Blood Cells Mol Dis 39:245-54. 2007
    ..Thus, we speculate that suppression of iron decompartmentalization, with the combination of quercetin and serum albumin might be a new approach in the prevention of reduced survival of erythrocytes in visceral leishmaniasis...
  37. ncbi Effects of physiological parameters on the electrical properties of blood bank stored erythrocyte suspensions
    Mana Sezdi
    Bogazici University, Institute of Biomedical Engineering, Istanbul
    Conf Proc IEEE Eng Med Biol Soc 1:5133-6. 2006
    ..By applying the multi-regression analysis, it is concluded that Ri, Re and Cm are appropriate for modeling Na+, K+, Cl-, pH and ATP during blood bank storage and predicting blood quality...
  38. ncbi Rapid cell corpse clearance by stabilin-2, a membrane phosphatidylserine receptor
    S Y Park
    Department of Biochemistry and Cell Biology, Cell and Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu, Korea
    Cell Death Differ 15:192-201. 2008
    ..These data indicate that stabilin-2 is the first of the membrane PS receptors to provide tethering and tickling signals, and may also be involved in the resolution of inflammation and the prevention of autoimmunity...
  39. ncbi Red cell transfusion in medicine: future challenges
    V M J Novotny
    Department of Blood Transfusion and Transplantation Immunology 469, Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands
    Transfus Clin Biol 14:538-41. 2007
    ..It has been suggested that accelerated and/or aberrant forms of the physiological erythrocyte aging process underlie the red cell storage lesion...
  40. ncbi A fluorometric quantitative erythrophagocytosis assay using human THP-1 monocytic cells and PKH26-labelled red blood cells
    Geraldine Healey
    Research Unit, Australian Red Cross Blood Service, PO Box 354, South Melbourne, Victoria 3205 Australia
    J Immunol Methods 322:50-6. 2007
    ..The quantitative, fluorometric plate assay is very sensitive and has good reproducibility, making it a useful tool to investigate the biological mechanisms that regulate erythrophagocytosis of normal and diseased RBCs...
  41. ncbi Characterization of red cell membrane proteins as a function of red cell density: annexin VII in different forms of hereditary spherocytosis
    Marianna Caterino
    Dipartimento di Biochimica e Biotecnologie Mediche, Universita di Napoli Federico II, Via Pansini, 5 80131 Napoli, Italy
    FEBS Lett 580:6527-32. 2006
    ..Cytoskeletal anomalies may then influence the turn-over of annexin VII during erythrocyte maturation...
  42. ncbi Interlaboratory comparison of red-cell ATP, 2,3-diphosphoglycerate and haemolysis measurements
    J R Hess
    University of Maryland Medical School, Baltimore, MD 21201, USA
    Vox Sang 89:44-8. 2005
    ..The reproducibility of RBC ATP, DPG and haemolysis measurements between centres was investigated...
  43. ncbi Fas-, caspase 8-, and caspase 3-dependent signaling regulates the activity of the aminophospholipid translocase and phosphatidylserine externalization in human erythrocytes
    Debabrata Mandal
    Department of Chemistry, Bose Institute 93 1 Acharya Prafulla Chandra Road, Kolkata 700009, India
    J Biol Chem 280:39460-7. 2005
    ..Our data demonstrate for the first time the novel involvement of Fas/caspase 8/caspase 3-dependent signaling in an enucleated cell leading to PS externalization, a central feature of erythrophagocytosis and erythrocyte biology...
  44. ncbi Erythrocyte glycohydrolases in subjects with trisomy 21: could Down's syndrome be a model of accelerated ageing?
    L Massaccesi
    Department of Medical Chemistry, Biochemistry and Biotechnology, University of Milan, Via Saldini 50, 20133 Milan, Italy
    Mech Ageing Dev 127:324-31. 2006
    ..These findings indicate that erythrocyte ageing in DS differs partially from that of age-matched and elderly controls. In any case, the accelerated ageing seen in DS is no fully comparable to physiological ageing...
  45. ncbi Reduced expression of CD47 on stored red blood cells
    Rosemary Sparrow
    Transfusion 46:1263. 2006
  46. ncbi Cellular properties of human erythrocytes preserved in saline-adenine-glucose-mannitol in the presence of L-carnitine
    Arduino Arduini
    Department of Research and Development, Iperboreal Pharma S r l, Chieti, Italy
    Am J Hematol 82:31-40. 2007
    ..LC reduces the swelling of older cells during storage at 4 degrees C in SAG-M, possibly by acting on the permeability of cell membrane to monovalent cations...
  47. ncbi Stimulation of eryptosis by aluminium ions
    Olivier M Niemoeller
    Department of Physiology, University of Tubingen, Germany
    Toxicol Appl Pharmacol 217:168-75. 2006
    ..Both effects are expected to decrease the life span of circulating erythrocytes and presumably contribute to the development of anemia during Al(3+) intoxication...
  48. ncbi Clinical consequences of red cell storage in the critically ill
    Alan Tinmouth
    Center for Transfusion and Critical Care Research, Clinical Epidemiology Unit, Critical Care Program, University of Ottawa and Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Transfusion 46:2014-27. 2006
    ..These data suggest a possible detrimental clinical effect associated with the transfusion of stored RBCs; randomized clinical trials further evaluating the clinical consequences of transfusing older stored RBCs are required...
  49. ncbi Bovine red blood cell starvation age discrimination through a glutaraldehyde-amplified dielectrophoretic approach with buffer selection and membrane cross-linking
    Zachary Gagnon
    Department of Chemical and Biomolecular Engineering, Center for Microfluidics and Medical Diagnostics, University of Notre Dame, Notre Dame, IN 46556, USA
    Electrophoresis 29:2272-9. 2008
    ..treatment. It is then expected that rapid identification and sorting of healthy from diseased cells can be similarly sensitized...
  50. ncbi Thermal lability of membrane proteins of age separated erythrocytes as studied by electron spin resonance spin label technique
    G Bartosz
    Experimentalphysik III, Gesamthochschule Kassel, Bundesrepublik Deutschland
    Z Naturforsch C 42:1343-4. 1987
    ..1 degrees C. Our results show that "old" erythrocyte membrane proteins are less stable against thermal denaturation then "young" cells...
  51. ncbi Spin label studies of erythrocytes during storage of blood
    G P Pessina
    Dipartimento di Chimica, Universita degli Studi di Siena, Italy
    Z Naturforsch C 44:824-8. 1989
    ..Signal decay of MAL-6 is a further proof that during storage of blood under blood bank conditions or during an artificial ageing of erythrocytes at 37 degrees C, profound modifications occur in the human erythrocyte membrane...
  52. ncbi Identification of the molecular defect in the erythrocyte membrane skeleton of some kindreds with hereditary spherocytosis
    S R Goodman
    Blood 60:772-84. 1982
    ..It would appear therefore that the defective HS spectrin-protein-4.1 interaction in type I hereditary spherocytosis may be the primary molecular defect rather than a secondary phenomena...
  53. ncbi Functional analysis of aquaporin-1 deficient red cells. The Colton-null phenotype
    J C Mathai
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2185, USA
    J Biol Chem 271:1309-13. 1996
    ..The ratio of AQP1-mediated Pf to Pd predicts the length of the aqueous pore to be 36 A...
  54. ncbi Human erythroid cells are affected by aluminium. Alteration of membrane band 3 protein
    Daniela Vittori
    Laboratorio de Analisis Biologicos, Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellon II, Piso 4 Ciudad Universitaria, 1428 Buenos Aires, Argentina
    Biochim Biophys Acta 1558:142-50. 2002
    ..The present in vitro results suggest that Al may disturb human erythropoiesis through combined effects on mature erythrocytes and cellular metabolism in late erythroid progenitors...
  55. ncbi [Heme metabolism and oxidative stress]
    P A Kaliman
    Kharkiv Karazin National University
    Ukr Biokhim Zh 73:5-15. 2001
    ..transport and exchange processes of exogenous heme and heme liberated from erythrocyte hemoglobin under erythrocyte aging and hemolysis...
  56. ncbi The cytoskeleton in ATP-depleted erythrocytes: the effect of shape transformation
    Y Marikovsky
    Department of Membrane Research and Biophysics, Weizmann Institute of Science, Rehovot, Israel
    Mech Ageing Dev 86:137-44. 1996
    b>Erythrocyte aging, accompanied by reduced deformability and low ATP level, is considered to be among the factors limiting the survival of old erythrocytes...
  57. ncbi The phosphatidylserine receptor mediates phagocytosis by vascular smooth muscle cells
    S Kolb
    INSERM, U698 Haematology, Bio Engineering and Cardiovascular Remodelling, Paris F 75018, France
    J Pathol 212:249-59. 2007
    ..The mechanisms underlying phagocytosis and involving PSR in vivo, within the pathological arterial wall, deserve further investigation...
  58. ncbi The microrheological behavior of young and old red blood cells in athletes
    A V Muravyov
    Department of Medicine and Biology, Yaroslavl University, Yaroslavl, Russia
    Clin Hemorheol Microcirc 26:183-8. 2002
    ..It was one of the cause of high fluidity of the RBCtop- and RBCbot suspensions and whole blood in athletes and more effective oxygen transport than in untrained people...
  59. ncbi Sequential regulation of ferroportin expression after erythrophagocytosis in murine macrophages: early mRNA induction by haem, followed by iron-dependent protein expression
    Constance Delaby
    INSERM U773, Centre de Recherche Biomedicale Bichat Beaujon CRB3, Universite Denis Diderot, site Bichat, 75870 Paris Cedex 18, France
    Biochem J 411:123-31. 2008
    ..These findings highlight a dual mechanism of Fpn regulation in BMDMs, characterized by early induction of the gene transcription predominantly mediated by haem, followed by iron-mediated post-transcriptional regulation of the exporter...
  60. ncbi Rejuvenation of irradiated AS-1 red cells
    L H Samuel
    Department of Pathology, University of Virginia Health Sciences Center, Charlottesville, USA
    Transfusion 37:25-8. 1997
    ..Since in vivo recovery is related to red cell ATP levels, rejuvenation of stored irradiated units using a pyruvate-inosine phosphate-adenine additive was explored...
  61. ncbi Drugs for preventing red blood cell dehydration in people with sickle cell disease
    Srikanth Nagalla
    Department of Medicine, Division of Hematology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Cochrane Database Syst Rev 7:CD003426. 2012
    ..Recent research has focused on therapies to rehydrate the sickled cells by reducing the loss of water and ions from them. Little is known about the effectiveness and safety of such drugs...
  62. ncbi A genetic defect in the binding of protein 4.1 to spectrin in a kindred with hereditary spherocytosis
    L C Wolfe
    N Engl J Med 307:1367-74. 1982
    ..1, but the other functioned normally. Presumable, the nonfunctional spectrin was the product of the autosomal dominant gene responsible for the hereditary spherocytosis in this kindred...
  63. ncbi Implementation of a redistribution system for near-outdate red blood cell units
    Lisa Denesiuk
    Dynacare Kasper Medical Laboratories, Regional Services, Edmonton, Alberta, Canada
    Arch Pathol Lab Med 130:1178-83. 2006
    ..In Canada, the blood supplier does not accept returned units into inventory. Discard rates can, therefore, be high...
  64. ncbi Effect of chronic kidney disease on red blood cell rheology
    K Scott Brimble
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Clin Hemorheol Microcirc 34:411-20. 2006
    ..This study measured blood viscosity over a range of shear rates in erythropoietin-treated patients on hemodialysis (HD), and compared the findings to matched patients with chronic renal insufficiency (CRI) and healthy controls...
  65. ncbi Intravascular hemolysis and mean red blood cell age in athletes
    Yohan Robinson
    Charite Campus Benjamin Franklin, Institute for Sports Medicine, Berlin, Germany
    Med Sci Sports Exerc 38:480-3. 2006
    ..Recently gained knowledge questions the importance of mechanical RBC trauma on RBC hemolysis in athletes...
  66. ncbi Rescued mice with Hb E transgene-developed red cell changes similar to human beta-thalassemia/HbE disease
    Bundit Wannasuphaphol
    Thalassemia Research Center, Institute of Science and Technology for Research and Development, Mahidol University, Phuttamonthon, Nakornpathom 73170, Thailand
    Ann N Y Acad Sci 1054:407-16. 2005
    ..RBC life span and half-time of rescued red cells were shortened, indicating a rapid RBC destruction...
  67. ncbi Diethylcarbamazine: a leukotriene inhibitor. Effects on red cell deformability in-vitro and in-vivo survival during endotoxemia
    F B Rogers
    Cook County Hospital, Department of Surgery
    Int J Microcirc Clin Exp 14:22-6. 1994
    ..Leukotriene inhibition, with DEC improves red cell deformability in vitro, and may account, in part, for the improved survival seen in rat endotoxemia...
  68. ncbi Autologous and allogeneic red cell survival studies in the presence of autoanti-AnWj
    C F Whitsett
    Department of Pathology, Emory University Hospital, Atlanta, Georgia
    Transfusion 33:845-7. 1993
    ..These studies suggest that the specificity of the autoantibody may have implications for transfusion therapy when the development of such autoantibodies is associated with decreased antigen expression on the patient's cells...
  69. ncbi Dose-response relationship and pharmacogenetics of anti-RhD monoclonal antibodies
    David Ternant
    Blood 106:1503-4; author reply 1504-5. 2005
  70. ncbi [Immunohematologic study and transfusion approach to patients with public antibodies]
    P Solves
    Servicio de Hematologia y Hemoterapia, Hospital Universitario La Fe, Valencia
    Sangre (Barc) 42:25-9. 1997
    ..To analyze the different immunohematologic studies required to identify anti-red cell antibodies directed against high incidence antigens and comment the best tranfusion management...
  71. pmc Red cell survival in biliary cirrhosis
    R Hume
    J Clin Pathol 23:397-401. 1970
    ..It was concluded that the anaemia of cirrhosis of the liver, including primary biliary cirrhosis, may be due to a number of mechanisms and a unifying hypothesis based on the degree of liver dysfunction is suggested...
  72. ncbi Characterization of the calpastatin defect in erythrocytes from patients with essential hypertension
    S Pontremoli
    Institute of Biological Chemistry, University of Genoa, Italy
    Biochem Biophys Res Commun 157:867-74. 1988
    ....
  73. pmc Age of red blood cells and mortality in the critically ill
    Ville Pettila
    Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Commercial Road, Melbourne 3004, Victoria, Australia
    Crit Care 15:R116. 2011
    ..We hypothesized that exposure to even a single unit of older RBCs may be associated with an increased risk of death...
  74. ncbi Human red blood cell aging: correlative changes in surface charge and cell properties
    Yao Xiong Huang
    Institute of Biomedical Engineering, Ji Nan University, Guang Zhou, China
    J Cell Mol Med 15:2634-42. 2011
    ..This quantitative approach not only clarifies the picture but also has implications in biology and medicine...
  75. ncbi Peroxyl-induced oxidative stress in aging erythrocytes of rat
    S Asha Devi
    Department of Zoology, Laboratory of Gerontology, Bangalore University, Bangalore, 560 056, India
    Biogerontology 12:283-92. 2011
    ..These findings suggest that young erythrocytes may benefit from vitamin C in therapies addressed towards the mechanisms underlying the reduced effects of OS...
  76. pmc Learning about genomics and disease from the anucleate human red blood cell
    Edward J Benz
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 120:4204-6. 2010
    ..This work provides important insights into ways in which epigenetic changes can alter gene expression and thereby lead to human disease...
  77. ncbi Examination of aggregation of various red blood cell populations can be informative in comparison of splenectomy and spleen autotransplantation in animal experiments
    Ferenc Kiss
    Department of Operative Techniques and Surgical Research, Institute of Surgery, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
    Clin Hemorheol Microcirc 45:273-80. 2010
    ..Consequently, the comparison of aggregation and deformability properties of "young" and "old" erythrocytes may give important information about the function of the spleen...
  78. pmc Role of the membrane in the formation of heme degradation products in red blood cells
    Enika Nagababu
    Molecular Dynamics Section, National Institute on Aging, National Institutes of Health, 251 Bay View Blvd, Baltimore, MD 21224, United States
    Life Sci 86:133-8. 2010
    ..We investigated the possibility that the observed heme degradation results from ROS generated on the membrane surface that are relatively inaccessible to the cellular antioxidants...
  79. ncbi Eryptosis in hereditary spherocytosis and thalassemia: role of glycoconjugates
    Sumanta Basu
    Biophysics Division, Saha Institute of Nuclear Physics, 1 AF Bidhannagar, Kolkata, 700064, India
    Glycoconj J 27:717-22. 2010
    ..The loss of PS asymmetry together with the cell surface glycoproteins mediated by membrane vesiculation, seemed to play key role in early clearance of erythrocytes from circulation following a mechanism similar to HbEβ-thalassemia...
  80. ncbi 24-hour 51Cr post-transfusion survival, 51Cr life span and haemolysis of red blood cells stored at 4 degrees C for 56 days in AS-3
    C R Valeri
    Naval Blood Research Laboratory, Boston University School of Medicine, 615 Albany Street, Boston, MA 02118, USA
    Vox Sang 80:48-50. 2001
    ..The purpose was to compare the outcome of the autotransfused red cells collected by both techniques...
  81. ncbi RBC-derived vesicles during storage: ultrastructure, protein composition, oxidation, and signaling components
    Anastasios G Kriebardis
    Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis, Greece
    Transfusion 48:1943-53. 2008
    ..The vesiculation of the RBCs is a part of the storage lesion. The protein composition of the vesicles generated during storage of banked RBCs has not been studied in detail...
  82. ncbi A truncated erythropoietin receptor that fails to prevent programmed cell death of erythroid cells
    Y Nakamura
    Laboratory of Cell Growth and Differentiation, Tsukuba Life Science Center, Japan
    Science 257:1138-41. 1992
    ..EPOR-F may transduce a signal to prevent programmed cell death that is independent of the mitogenic signal, and alternative splicing of the EPOR gene may have an important role in erythropoiesis...
  83. ncbi Contribution of propylene glycol-induced Heinz body formation to anemia in cats
    M M Christopher
    Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, St Paul 55108
    J Am Vet Med Assoc 194:1045-56. 1989
    ....
  84. ncbi Shortened red blood cell lifespan is related to the dose of erythropoiesis-stimulating agents requirement in patients on hemodialysis
    Yasuyuki Sato
    Dialysis, Kawashima Hospital, Tokushima, Tokushima, Japan
    Ther Apher Dial 16:522-8. 2012
    ..RBC lifespan. A shortened RBC lifespan seems to rather significantly affect the ESA requirement. Better nutritional status or active HD patients also seem to have longer RBC lifespans and lower ESA requirement...
  85. ncbi Method of determination of the reticulocyte age distribution from flow cytometry count by a structured-population model
    Paweł Wiczling
    Department of Pharmaceutical Sciences, University at Buffalo, Buffalo, New York 14260, USA
    Cytometry A 71:460-7. 2007
    ..A new method of determination of the RNA degradation rate in RET is provided. This technique allows one to determinate the age distribution of RET...
  86. ncbi Development of B cells producing natural autoantibodies to thymocytes and senescent erythrocytes
    Richard R Hardy
    Division of Basic Sciences, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA
    Springer Semin Immunopathol 26:363-75. 2005
    ....
  87. ncbi [Hemorheology and physiological function--factors influencing blood viscosity]
    Nobuharu Maeda
    Nihon Seirigaku Zasshi 66:287-97. 2004
  88. pmc Molecular cloning and expression of a chloride channel-associated protein pICln in human young red blood cells: association with actin
    R S Schwartz
    Division of Hematology, Albert Einstein College of Medicine Montefiore Medical Center, 111 East 210th Street, Bronx, NY 10467, USA
    Biochem J 327:609-16. 1997
    ..Moreover the association of RBC pICln with actin offers a model in which to test interactions between RBC ion channels and the cytoskeleton...
  89. ncbi Variation of micronucleated erythrocytes in peripheral blood of Sciurus aureogaster in relation to age: an increment of micronucleated polychromatic erythrocytes after the administration of colchicine
    G Zuniga-Gonzalez
    Laboratorio de Mutagénesis, Centro de Investigacion Biomedica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Mexico
    Environ Mol Mutagen 37:173-7. 2001
    ..These results showed that in the gray squirrel, the number of spontaneous MNE in peripheral blood depend on age. An additional interesting datum about the increment of MNE after the administration of colchicine is shown...
  90. ncbi Can we use erythrocytes for the study of the activity of the ubiquitous Na+/H+ exchanger (NHE-1) in essential hypertension?
    S N Orlov
    Laboratory of Biomembranes, Faculty of Biology, MV Lomonosov Moscow State University, Russia
    Am J Hypertens 11:774-83. 1998
    ....
  91. ncbi A comparison of the in vivo kinetics of Plasmodium falciparum ring-infected erythrocyte surface antigen-positive and -negative erythrocytes
    P N Newton
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Blood 98:450-7. 2001
    ..017) after treatment with an artemisinin derivative than after treatment with quinine. Parasitization of red cells leads to changes in the erythrocyte that shorten their survival even if the parasite is removed subsequently...
  92. ncbi Simplification of the end-alveolar carbon monoxide technique to assess erythrocyte survival
    Julie K Furne
    Minneapolis Veterans Affairs Medical Center, Minneapolis, MN 55417, USA
    J Lab Clin Med 142:52-7. 2003
    ..Measurement of CO in samples collected by these four subjects in their home environments indicated that each had a shortened RBC life span (range 30-69 days)...
  93. ncbi Band 3 and its alterations in health and disease
    M M Kay
    Department of Neurology, University of Geneva Hospital, Micheli du Crest 24, CH 1211, Geneva, Switzerland
    Cell Mol Biol (Noisy-le-grand) 50:117-38. 2004
    ..Mutations in other genes can cause changes in band 3. An example is sickle cell anemia where the increased oxidation causes accelerated aging of band 3 and increased IgG binding and cellular removal...
  94. ncbi Characterization of binding and phagocytosis of oxidatively damaged erythrocyte to macrophage
    Hong Sook Ko
    Division of Cardiology, Department of Internal Medicine, College of Medicine, Chung Ang University, Seoul, Korea
    Korean J Intern Med 17:220-6. 2002
    ..However, there are controversies about the kind of receptors and ligands related to the binding. Macrophages lacking class A scavenger receptor show identical binding of oxRBC with wild-type ones...
  95. ncbi An "optical channel": a technique for the evaluation of biological cell elasticity
    T Kaneta
    Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, Hakozaki, Fukuoka, Japan
    Anal Chem 73:5791-5. 2001
    ..These values are in reasonably good agreement with values obtained using a rheoscope method. The deformation was measured without any physical contact to the solid surface, and therefore, damage to cells such as these are minimal...
  96. ncbi Survival of the fittest?--survival of stored red blood cells after transfusion
    M Luten
    Department of Research and Development, Sanquin Blood Bank Southeast Region, P O Box 1013, 6501 BA Nijmegen, The Netherlands
    Cell Mol Biol (Noisy-le-grand) 50:197-203. 2004
    ..1% for the measurement of survival in vivo based on antigenic differences. This technique has various advantages compared with the 'classical' 51Cr survival method...
  97. ncbi Gamma-tubulin in chicken erythrocytes: changes in localization during cell differentiation and characterization of cytoplasmic complexes
    Irena Linhartova
    Department of Biology of the Cytoskeleton, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Dev Dyn 223:229-40. 2002
    ....
  98. pmc Autoimmune haemolytic anaemias. IV. Biochemical studies of red cells from patients with autoimmune haemolytic anaemia with incomplete warm autoantibodies
    - Borne AE von dem
    Clin Exp Immunol 8:377-88. 1971
  99. pmc An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe(-/-) mice and ameliorates anemia and iron overload in murine β-thalassemia intermedia
    Paul J Schmidt
    Department of Pathology, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    Blood 121:1200-8. 2013
    ....
  100. ncbi Oxidative stress due to aluminum exposure induces eryptosis which is prevented by erythropoietin
    Daiana M Vota
    Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellon II, Piso 4, Ciudad Universitaria, Ciudad Autonoma de Buenos Aires, C1428EHA, Argentina
    J Cell Biochem 113:1581-9. 2012
    ..Irrespective of the antioxidant mechanism, this property of EPO, shown in this model of Al exposure, let us suggest potential benefits by EPO treatment of patients with anemia associated to altered redox environment...
  101. ncbi The multiple functions of hemoglobin
    B Giardina
    Istituto di Chimica e Chimica Clinica, Facolta di Medicina e Chirurgia, Universita Cattolica, Roma, Italy
    Crit Rev Biochem Mol Biol 30:165-96. 1995
    ....

Research Grants8

  1. MAGNETIC NANOSENSORS FOR BIOMEDICAL ANALYSES OF MICROVESICLES
    Hakho Lee; Fiscal Year: 2013
    ..cardiovascular diseases, diabetes, and inflammation;MVs also appear to play an integral role in the erythrocyte aging process...
  2. THE ROLE OF CONTRACTILE PROTEINS IN ERYTHROCYTE AGING
    DIANE LIN; Fiscal Year: 1980
    ..With these studies, we hope to establish a correlation between the state of the contractile proteins and the age-related rigidity of the red cell membrane...
  3. BD Biosciences LSR Flow Cytometer
    Richard Hardy; Fiscal Year: 2002
    ..abstract_text> ..
  4. GENETIC ENGINEERING OF CELLS FROM ANEMIC ANIMALS
    Jane Barker; Fiscal Year: 2003
    ..abstract_text> ..
  5. IMMUNOGLOBULIN V GENES AND B CELL DEVELOPMENT
    Richard Hardy; Fiscal Year: 2006
    ..The results of these studies will help to establish the types of selection that shape the expressed B cell repertoire, both fetally and in the adult, with implications for modulating normal and autoimmune responses. ..
  6. FACSVantage SE Sorting Flow Cytometer
    Jane Barker; Fiscal Year: 2002
    ..Funds are requested to purchase the FACSVantage SE and the optional equipment for TJL's Flow Cytometry Service. This will provide a cost-effective way to fill an urgent need of TJL's principal investigators. ..