cell shape

Summary

Summary: The quality of surface form or outline of CELLS.

Top Publications

  1. pmc PGE(2) inhibition of TGF-beta1-induced myofibroblast differentiation is Smad-independent but involves cell shape and adhesion-dependent signaling
    Peedikayil E Thomas
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI 48109 2200, USA
    Am J Physiol Lung Cell Mol Physiol 293:L417-28. 2007
  2. ncbi Matrix elasticity directs stem cell lineage specification
    Adam J Engler
    Pennsylvania Muscle Institute, University of Pennsylvania, Philadelphia, 19104, USA
    Cell 126:677-89. 2006
  3. ncbi Tensional homeostasis and the malignant phenotype
    Matthew J Paszek
    Department of Bioengineering, University of Pennsylvania, Philadelphia, 19104, USA
    Cancer Cell 8:241-54. 2005
  4. pmc Coordination of Rho GTPase activities during cell protrusion
    Matthias Machacek
    Department of Cell Biology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, California 92037, USA
    Nature 461:99-103. 2009
  5. pmc Actin, a central player in cell shape and movement
    Thomas D Pollard
    Department of Molecular, Cellular and Developmental Biology, Yale University, Post Office Box 208103, New Haven, CT 06520 8103, USA
    Science 326:1208-12. 2009
  6. ncbi Cell surface mechanics and the control of cell shape, tissue patterns and morphogenesis
    Thomas Lecuit
    Institute of Developmental Biology of Marseille Luminy, UMR6216 CNRS Université de la Méditerranée, Campus de Luminy Case 907, 13288 Marseille Cedex 09, France
    Nat Rev Mol Cell Biol 8:633-44. 2007
  7. pmc Cultivation of human corneal endothelial cells isolated from paired donor corneas
    Gary S L Peh
    Singapore Eye Research Institute, Singapore, Singapore
    PLoS ONE 6:e28310. 2011
  8. ncbi Local force and geometry sensing regulate cell functions
    Viola Vogel
    Laboratory for Biologically Oriented Materials, Department of Materials, Swiss Federal Institute of Technology ETH, Zurich, Wolfgang Pauli Strasse 10, ETH Honggerberg, HCI F443, CH 8093 Zurich, Switzerland
    Nat Rev Mol Cell Biol 7:265-75. 2006
  9. pmc Stem cell shape regulates a chondrogenic versus myogenic fate through Rac1 and N-cadherin
    Lin Gao
    Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Stem Cells 28:564-72. 2010
  10. pmc An adhesion-dependent switch between mechanisms that determine motile cell shape
    Erin L Barnhart
    Department of Biochemistry and Howard Hughes Medical Institute, Stanford School of Medicine, Stanford, California, United States of America
    PLoS Biol 9:e1001059. 2011

Research Grants

  1. Peptidoglycan Biogenesis in Escherichia Coli
    Thomas G Bernhardt; Fiscal Year: 2010
  2. Blood Brain Barrier Physiology and HIV Dementia
    HOWARD GENDELMAN; Fiscal Year: 2007
  3. DNA-crosslinked gels: New advanced biomaterials
    NOSHIR LANGRANA; Fiscal Year: 2006
  4. METABOLISM OF THE TRABECULAR MESHWORK
    David Epstein; Fiscal Year: 2000
  5. Quantitative Analysis of Chemotactic Motility Cycle of Ameboid Cells
    JUAN CARLOS contact LASHERAS; Fiscal Year: 2010
  6. MOLECULAR ANALYSIS OF TREPONEMAL MOTILITY GENES
    RONALD LIMBERGER; Fiscal Year: 2002
  7. MECHANISM OF RETROCORNEAL FIBROUS MEMBRANE
    EUNDUCK KAY; Fiscal Year: 2007
  8. The biomechanics of morphogenesis in the frog
    Lance A Davidson; Fiscal Year: 2010
  9. A Mutagenic Study of Yeast Actin Conformational Changes
    PETER RUBENSTEIN; Fiscal Year: 2006
  10. MYOSIN MOVEMENT IN VITRO--MOLECULAR CHARACTERIZATION
    James Spudich; Fiscal Year: 1999

Detail Information

Publications249 found, 100 shown here

  1. pmc PGE(2) inhibition of TGF-beta1-induced myofibroblast differentiation is Smad-independent but involves cell shape and adhesion-dependent signaling
    Peedikayil E Thomas
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI 48109 2200, USA
    Am J Physiol Lung Cell Mol Physiol 293:L417-28. 2007
    ..Rather, PGE(2) has dramatic effects on cell shape and cytoskeletal architecture and disrupts the formation of appropriate focal adhesions...
  2. ncbi Matrix elasticity directs stem cell lineage specification
    Adam J Engler
    Pennsylvania Muscle Institute, University of Pennsylvania, Philadelphia, 19104, USA
    Cell 126:677-89. 2006
    ..The results have significant implications for understanding physical effects of the in vivo microenvironment and also for therapeutic uses of stem cells...
  3. ncbi Tensional homeostasis and the malignant phenotype
    Matthew J Paszek
    Department of Bioengineering, University of Pennsylvania, Philadelphia, 19104, USA
    Cancer Cell 8:241-54. 2005
    ..Thus, ERK and Rho constitute part of an integrated mechanoregulatory circuit linking matrix stiffness to cytoskeletal tension through integrins to regulate tissue phenotype...
  4. pmc Coordination of Rho GTPase activities during cell protrusion
    Matthias Machacek
    Department of Cell Biology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, California 92037, USA
    Nature 461:99-103. 2009
    ....
  5. pmc Actin, a central player in cell shape and movement
    Thomas D Pollard
    Department of Molecular, Cellular and Developmental Biology, Yale University, Post Office Box 208103, New Haven, CT 06520 8103, USA
    Science 326:1208-12. 2009
    ..Comparisons of quantitative measurements of reactions in live cells with computer simulations of mathematical models will also help generate meaningful insights...
  6. ncbi Cell surface mechanics and the control of cell shape, tissue patterns and morphogenesis
    Thomas Lecuit
    Institute of Developmental Biology of Marseille Luminy, UMR6216 CNRS Université de la Méditerranée, Campus de Luminy Case 907, 13288 Marseille Cedex 09, France
    Nat Rev Mol Cell Biol 8:633-44. 2007
    ..However, how this information is processed to control cell shape and cell dynamics is an open area of investigation...
  7. pmc Cultivation of human corneal endothelial cells isolated from paired donor corneas
    Gary S L Peh
    Singapore Eye Research Institute, Singapore, Singapore
    PLoS ONE 6:e28310. 2011
    ....
  8. ncbi Local force and geometry sensing regulate cell functions
    Viola Vogel
    Laboratory for Biologically Oriented Materials, Department of Materials, Swiss Federal Institute of Technology ETH, Zurich, Wolfgang Pauli Strasse 10, ETH Honggerberg, HCI F443, CH 8093 Zurich, Switzerland
    Nat Rev Mol Cell Biol 7:265-75. 2006
    ..Recent tissue scaffolds that have been engineered at the micro- and nanoscale level now enable better dissection of the mechanosensing, transduction and response mechanisms...
  9. pmc Stem cell shape regulates a chondrogenic versus myogenic fate through Rac1 and N-cadherin
    Lin Gao
    Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Stem Cells 28:564-72. 2010
    ..Our previous work revealed that cell shape regulates hMSC commitment between osteoblasts and adipocytes through RhoA signaling...
  10. pmc An adhesion-dependent switch between mechanisms that determine motile cell shape
    Erin L Barnhart
    Department of Biochemistry and Howard Hughes Medical Institute, Stanford School of Medicine, Stanford, California, United States of America
    PLoS Biol 9:e1001059. 2011
    ....
  11. pmc Theoretical model for cellular shapes driven by protrusive and adhesive forces
    Doron Kabaso
    Department of Chemical Physics, The Weizmann Institute of Science, Rehovot, Israel
    PLoS Comput Biol 7:e1001127. 2011
    The forces that arise from the actin cytoskeleton play a crucial role in determining the cell shape. These include protrusive forces due to actin polymerization and adhesion to the external matrix...
  12. doi Cytoskeletal dynamics and supracellular organisation of cell shape fluctuations during dorsal closure
    Guy B Blanchard
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
    Development 137:2743-52. 2010
    ..Our results suggest that cell shape fluctuations are a property of cells with low and increasing levels of apical myosin, and that medial and ..
  13. pmc Bacterial actin MreB assembles in complex with cell shape protein RodZ
    Fusinita van den Ent
    MRC Laboratory of Molecular Biology, Cambridge, UK
    EMBO J 29:1081-90. 2010
    Bacterial actin homologue MreB is required for cell shape maintenance in most non-spherical bacteria, where it assembles into helical structures just underneath the cytoplasmic membrane...
  14. doi Local positive feedback regulation determines cell shape in root hair cells
    Seiji Takeda
    Department of Cell and Developmental Biology, John Innes Centre, Norwich NR4 7UH, UK
    Science 319:1241-4. 2008
    ..Because the location and stability of growth sites predict the ultimate form of a plant cell, our findings demonstrate how a positive feedback mechanism involving RHD2, ROS, and Ca2+ can determine cell shape.
  15. pmc RhoA and RhoC have distinct roles in migration and invasion by acting through different targets
    Francisco M Vega
    Randall Division of Cell and Molecular Biophysics, King s College London, London SE1 1UL, England, UK
    J Cell Biol 193:655-65. 2011
    ..We propose that RhoA contributes to migratory cell polarity through ROCK2-mediated suppression of Rac1 activity in lamellipodia, whereas RhoC promotes polarized migration through FMNL3 by restricting lamellipodial broadening...
  16. pmc Vimentin induces changes in cell shape, motility, and adhesion during the epithelial to mesenchymal transition
    Melissa G Mendez
    Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    FASEB J 24:1838-51. 2010
    ..cell lines, we show that the level of expression of vimentin IFs (VIFs) correlates with mesenchymal cell shape and motile behavior...
  17. pmc Triggering a cell shape change by exploiting preexisting actomyosin contractions
    Minna Roh-Johnson
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Science 335:1232-5. 2012
    ..We found that apical actomyosin contractions began before cell shape changes in both Caenorhabitis elegans and Drosophila. In C...
  18. pmc The regulation of traction force in relation to cell shape and focal adhesions
    Andrew D Rape
    Department of Biomedical Engineering, Carnegie Mellon University, PTC 4105 07, 700 Technology Drive, Pittsburgh, PA 15219, USA
    Biomaterials 32:2043-51. 2011
    ..A similar positive feedback control may allow cells to respond to a variety of physical or topographical signals via a unified mechanism...
  19. doi Pulsation and stabilization: contractile forces that underlie morphogenesis
    Adam C Martin
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Dev Biol 341:114-25. 2010
    Embryonic development involves global changes in tissue shape and architecture that are driven by cell shape changes and rearrangements within cohesive cell sheets...
  20. doi Cell shape, cell-cell contact, cell-extracellular matrix contact and cell polarity are all required for the maximum induction of CYP2B1 and CYP2B2 gene expression by phenobarbital in adult rat cultured hepatocytes
    Hiroaki Oda
    Laboratory of Nutritional Biochemistry, Department of Applied Molecular Biosciences, Nagoya University, Nagoya 464 8601, Japan
    Biochem Pharmacol 75:1209-17. 2008
    The effect of cell shape, cell density, contact with extracellular matrix and cell polarity on the phenobarbital (PB)-induced gene expression of CYP2B1 and CYP2B2 (CYP2B1/2B2) in adult rat hepatocytes was investigated...
  21. pmc Emergence of large-scale cell morphology and movement from local actin filament growth dynamics
    Catherine I Lacayo
    Department of Biochemistry, Stanford University, Stanford, California, United States of America
    PLoS Biol 5:e233. 2007
    ..of natural cell-to-cell variation within a population by using measurable morphological and behavioral features--cell shape, leading-edge shape, filamentous actin (F-actin) distribution, cell speed, and directional persistence--that we ..
  22. doi Adhesion signaling - crosstalk between integrins, Src and Rho
    Stephan Huveneers
    Division of Toxicology, Leiden Amsterdam Center for Drug Research, Leiden University, 2300 RA Leiden, The Netherlands
    J Cell Sci 122:1059-69. 2009
    ..We also discuss how this signaling network can regulate a range of cellular processes that are important for normal tissue function and disease, including cell adhesion, spreading, migration and mechanotransduction...
  23. pmc Apical constriction: a cell shape change that can drive morphogenesis
    Jacob M Sawyer
    Biology Department, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Dev Biol 341:5-19. 2010
    ..b>Cell shape changes and tissue movements like these are at the core of many of the morphogenetic movements that shape animal ..
  24. doi Dpp signaling promotes the cuboidal-to-columnar shape transition of Drosophila wing disc epithelia by regulating Rho1
    Thomas J Widmann
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr 108, 01307 Dresden, Germany
    J Cell Sci 122:1362-73. 2009
    Morphogenesis is largely driven by changes in the shape of individual cells. However, how cell shape is regulated in developing animals is not well understood...
  25. pmc Ordered patterns of cell shape and orientational correlation during spontaneous cell migration
    Yusuke T Maeda
    Department of Physics, Graduate School of Science, The University of Tokyo, Tokyo, Japan
    PLoS ONE 3:e3734. 2008
    ..Yet little is known about how cells change their own shape and how cells coordinate the deformation and movement. Here, we investigated the mechanism of spontaneous cell migration by using computational analyses...
  26. ncbi Growth stimulation leads to cellular senescence when the cell cycle is blocked
    Zoya N Demidenko
    Oncotarget, Albany, New York, USA
    Cell Cycle 7:3355-61. 2008
    ..Inhibition of TOR partially prevented senescent phenotype caused by DOX. Thus growth stimulation coupled with cell cycle arrest leads to senescence, whereas quiescence (a condition with inactive TOR) prevents senescence...
  27. pmc Automated characterization of cell shape changes during amoeboid motility by skeletonization
    Yuan Xiong
    Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD 21218, USA
    BMC Syst Biol 4:33. 2010
    ....
  28. pmc Coupling actin flow, adhesion, and morphology in a computational cell motility model
    Danying Shao
    Center for Theoretical Biological Physics and Department of Physics, University of California, San Diego, La Jolla, CA 92093 0374, USA
    Proc Natl Acad Sci U S A 109:6851-6. 2012
    ..Our model suggests that the pattern of the actin flow inside the cell, the cell velocity, and the cell morphology are determined by the integration of actin polymerization, myosin contraction, adhesion forces, and membrane forces...
  29. pmc Apical accumulation of Rho in the neural plate is important for neural plate cell shape change and neural tube formation
    Nagatoki Kinoshita
    Electron Microscope Laboratory and Organogenesis and Neurogenesis Group, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan
    Mol Biol Cell 19:2289-99. 2008
    ..signaling pathway, the Wnt/PCP pathway, was implicated in the apical accumulation of Rho and regulation of cell shape in the neural plate, suggesting that this signal may be the spatiotemporal regulator of Rho in neural tube ..
  30. doi Establishment and characterization of a lactating bovine mammary epithelial cell model for the study of milk synthesis
    Ke Zhao
    Institute of Dairy Science, MOE Key Laboratory of Molecular Animal Nutrition, Zhejiang University, No 268 Kaixuan Road, Hangzhou 310029, Peoples Republic of China
    Cell Biol Int 34:717-21. 2010
    ..The transcription of the alphas1 casein gene and synthesis of alphas caseins were also detected in the model. Thus, our lactating BMEC model can be an effective model in vitro for studies of milk synthesis in the bovine mammary gland...
  31. pmc Cell shape and substrate rigidity both regulate cell stiffness
    Shang You Tee
    Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Biophys J 100:L25-7. 2011
    ..It is currently unknown how substrate stiffness, cell shape, and cell stiffness modulate or interact with one another...
  32. pmc Universal rule for the symmetric division of plant cells
    Sébastien Besson
    Department of Organismic and Evolutionary Biology, Harvard University, The Biological Laboratories, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 108:6294-9. 2011
    ..most recent algal ancestors confirms that the probability distribution is widely conserved and independent of cell shape and size...
  33. pmc Balanced Rac1 and RhoA activities regulate cell shape and drive invagination morphogenesis in epithelia
    Bharesh K Chauhan
    Division of Pediatric Ophthalmology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 108:18289-94. 2011
    ..Here we show that mutual antagonism by the small Rho GTPases Rac1 and RhoA determines cell shape, tissue curvature, and invagination activity in the model epithelium of the developing mouse lens...
  34. pmc Inhibition of platelet-derived growth factor receptor signaling regulates Oct4 and Nanog expression, cell shape, and mesenchymal stem cell potency
    Stephen G Ball
    Wellcome Trust Centre for Cell Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester, UK
    Stem Cells 30:548-60. 2012
    ..In these PDGFR inhibitor-treated MSCs, Oct4 and Nanog expression and cell shape were regulated by janus kinase (JAK), MAPK kinase (MEK), and epidermal growth factor receptor (EGFR) signaling...
  35. pmc Bone morphogenetic protein-2-induced signaling and osteogenesis is regulated by cell shape, RhoA/ROCK, and cytoskeletal tension
    Yang Kao Wang
    Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    Stem Cells Dev 21:1176-86. 2012
    ..Here, we report that cell adhesion to extracellular matrix (ECM), and its effects on cell shape and cytoskeletal mechanics, regulates BMP-induced signaling and osteogenic differentiation of hMSCs...
  36. doi Cell shape changes indicate a role for extrinsic tensile forces in Drosophila germ-band extension
    Lucy C Butler
    Department of Physiology, Development and Neuroscience, University of Cambridge, UK
    Nat Cell Biol 11:859-64. 2009
    ..cell behaviours underlying tissue morphogenesis, we have continuously quantified cell intercalation and cell shape change during GBE...
  37. pmc Cell surface- and rho GTPase-based auxin signaling controls cellular interdigitation in Arabidopsis
    Tongda Xu
    Center for Plant Cell Biology, Department of Botany and Plant Sciences, University of California, Riverside, CA 92521, USA
    Cell 143:99-110. 2010
    ..These findings reveal Rho GTPase-based auxin-signaling mechanisms, which modulate the spatial coordination of cell expansion across a field of cells...
  38. ncbi Morphology, cytoskeletal organization, and myosin dynamics of mouse embryonic fibroblasts cultured on nanofibrillar surfaces
    Ijaz Ahmed
    Department of Pharmacology, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Mol Cell Biochem 301:241-9. 2007
    ..These results provide further evidence that nanofibrillar surfaces offer a significantly different environment for cells than 2D substrates...
  39. doi Subunits of the chaperonin CCT interact with F-actin and influence cell shape and cytoskeletal assembly
    Karen I Brackley
    Department of Cell and Molecular Biology, Göteborgs Universitet, Medicinaregatan 9C, 405 30 Goteborg, Sweden
    Exp Cell Res 316:543-53. 2010
    ..Reducing levels of individual CCT subunits implicates CCTepsilon in influencing cell shape and reduced levels of this subunit limit the cells' ability to recover from microfilament depolymerization...
  40. doi Sculpting the bacterial cell
    William Margolin
    Department of Microbiology and Molecular Genetics, University of Texas Medical School at Houston, 6431 Fannin Street, Houston, TX 77030, USA
    Curr Biol 19:R812-22. 2009
    ..Other bacteria that lack MreB homologs or even cell walls use distinct cytoskeletal systems to maintain their distinct shapes. Here I review what is known about the mechanisms that determine the shape of prokaryotic cells...
  41. ncbi Quantitative morphological study of microglial cells in the ischemic rat brain using principal component analysis
    Z Soltys
    Department of Neuroanatomy, Institute of Zoology, Jagiellonian University, 6 Ingardena St, 30 060 Cracow, Poland
    J Neurosci Methods 146:50-60. 2005
    ..The results presented show that the quantitative morphological analysis can be an effective tool in research on the reactive behaviour of microglia and, particularly, in the detection of small and early changes in the cells...
  42. doi Cell migration during morphogenesis
    Andy Aman
    University of Utah, Department Neurobiology and Anatomy, 20N Medical Drive, MREB 401, Salt Lake City, UT 84132, USA
    Dev Biol 341:20-33. 2010
    ..More importantly, we will highlight, compare and integrate recent advances in our understanding of how cell migration is regulated in these varied model systems with special emphasis on individual and collective cell movements...
  43. ncbi Shroom regulates epithelial cell shape via the apical positioning of an actomyosin network
    Jeffrey D Hildebrand
    Department of Biological Sciences, 4249 Fifth Avenue, Crawford Hall, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Cell Sci 118:5191-203. 2005
    ..These events likely mimic the cell shape changes and cellular movements required for neurulation in vivo...
  44. pmc Computational model for cell morphodynamics
    Danying Shao
    Center for Theoretical Biological Physics and Department of Physics, University of California, San Diego, La Jolla, California 92093 0374, USA
    Phys Rev Lett 105:108104. 2010
    ..Furthermore, we find that the dependence of the cell speed on this aspect ratio matches experimentally observed data...
  45. pmc The shape of motile cells
    Alex Mogilner
    Department of Neurobiology, Physiology and Behavior, University of California, Davis, CA 95616, USA
    Curr Biol 19:R762-71. 2009
    ..We start with geometric rules describing cell-edge kinetics that govern cell shape, followed by a discussion of the underlying biophysics; we consider actin treadmilling, actin-myosin contraction,..
  46. doi Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement
    Yuezhou Chen
    College of Life Science, Peking University, Beijing 100871, China
    Mol Cell 35:841-55. 2009
    ..Our studies reveal a previously unknown mechanism for controlling RhoA degradation and regulating RhoA function in various biological contexts, which involves a Cul3/BACURD ubiquitin ligase complex...
  47. doi Biological characterization of long-term cultured human mesenchymal stem cells
    Jiseon Kim
    Pharmacological Research Department, National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, 122 704, Korea
    Arch Pharm Res 32:117-26. 2009
    ..These findings suggest that diverse tests for cellular therapy should be considered during the ex vivo culture of hMSCs, particularly when a prolonged and extended propagation period is required...
  48. doi Polar actomyosin contractility destabilizes the position of the cytokinetic furrow
    Jakub Sedzinski
    Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany
    Nature 476:462-6. 2011
    ..Whether polar forces influence cytokinetic cell shape and furrow positioning remains an open question...
  49. doi Willin and Par3 cooperatively regulate epithelial apical constriction through aPKC-mediated ROCK phosphorylation
    Takashi Ishiuchi
    RIKEN Center for Developmental Biology, Chuo Ku, Kobe 650 0047, Japan
    Nat Cell Biol 13:860-6. 2011
    ..Thus, we have uncovered a Willin/Par3-aPKC-ROCK pathway that controls epithelial apical morphology...
  50. pmc Control of cortical rigidity by the cytoskeleton: emerging roles for septins
    Julia Gilden
    Department of Pathology, University of California at San Francisco, San Francisco, California 94143 0511, USA
    Cytoskeleton (Hoboken) 67:477-86. 2010
    ..walls, this cortex governs the contact between their plasma membranes and the environment and thereby influences cell shape, motility, and signaling...
  51. ncbi Phenotypic and functional characteristics of mesenchymal stem cells differentiated along a Schwann cell lineage
    Jenny Caddick
    Blond McIndoe Research Laboratories, University of Manchester, Manchester, United Kingdom
    Glia 54:840-9. 2006
    ..These findings support the assertion that MSCs can be differentiated into cells that are Schwann cell-like in terms of both phenotype and function...
  52. doi Hydrostatic pressure and the actomyosin cortex drive mitotic cell rounding
    Martin P Stewart
    ETH Zurich, Department of Biosystems Science and Engineering, CH 4058 Basel, Switzerland
    Nature 469:226-30. 2011
    ..Thus, by locally modulating actomyosin-cortex-dependent surface tension and globally regulating osmotic pressure, cells can control their volume, shape and mechanical properties...
  53. ncbi Dpp signalling orchestrates dorsal closure by regulating cell shape changes both in the amnioserosa and in the epidermis
    Beatriz García Fernández
    Instituto Gulbenkian de Ciencia, Rua da Quinta Grande 6, 2780 156 Oeiras, Portugal
    Mech Dev 124:884-97. 2007
    ..Embryos defective in Dpp signalling display defects in AS cell shape changes, specifically in the reduction of their apical surface areas, leading to defective AS contraction...
  54. pmc An SK3 channel/nWASP/Abi-1 complex is involved in early neurogenesis
    Stefan Liebau
    Institute for Anatomy and Cell Biology, Ulm University, Ulm, Germany
    PLoS ONE 6:e18148. 2011
    ..This observation indicates that the rearrangement of the actin based cytoskeleton via membrane bound SK3-channels might selectively be controlled in defined micro compartments of the cell...
  55. pmc Force transmission in migrating cells
    Maxime F Fournier
    Laboratoire de Biophysique Cellulaire, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
    J Cell Biol 188:287-97. 2010
    ....
  56. doi Isolation and characterization of resident mesenchymal stem cells in human glomeruli
    Stefania Bruno
    Department of Internal Medicine, Molecular Biotechnology Center and Research Center for Experimental Medicine CeRMS, University of Torino, Torino, Italy and Fresenius Medical Care, Bad Homburg, Germany
    Stem Cells Dev 18:867-80. 2009
    ..In conclusion, these results indicate the presence of a multipotent mesenchymal cell population resident in human glomeruli that may have a role in the physiological cell turnover and/or in response to glomerular injury...
  57. pmc A dynamic stochastic model of frequency-dependent stress fiber alignment induced by cyclic stretch
    Hui Ju Hsu
    Department of Biomedical Engineering, Texas A and M University, College Station, Texas, United States of America
    PLoS ONE 4:e4853. 2009
    ..While there is much evidence that cells reorganize their SFs in response to matrix deformations, it is unclear how cells and their SFs determine their specific response to particular spatiotemporal changes in the matrix...
  58. ncbi Morphological and electrophysiological properties of GABAergic and non-GABAergic cells in the deep cerebellar nuclei
    Marylka Uusisaari
    Laboratory for Neuronal Circuit Dynamics, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    J Neurophysiol 97:901-11. 2007
    ..We conclude that GABAergic DCN neurons are specialized to convey phasic spike rate information, whereas tonic spike rate is more faithfully relayed by the large non-GABAergic cells...
  59. pmc Difference in the cytotoxic effects of toxin B from Clostridium difficile strain VPI 10463 and toxin B from variant Clostridium difficile strain 1470
    Johannes Huelsenbeck
    Institut of Toxicology, Medical School, Hannover, D 30625 Hannover, Germany
    Infect Immun 75:801-9. 2007
    ..In conclusion, the protein substrate specificity of the glucosylating toxins determines their biological activity...
  60. ncbi Shroom family proteins regulate gamma-tubulin distribution and microtubule architecture during epithelial cell shape change
    Chanjae Lee
    Department of Molecular Cell and Developmental Biology, and Institute for Cellular and Molecular Biology, University of Texas, Austin, TX 78712, USA
    Development 134:1431-41. 2007
    b>Cell shape changes require the coordination of actin and microtubule cytoskeletons...
  61. ncbi Chemotaxis in shallow gradients is mediated independently of PtdIns 3-kinase by biased choices between random protrusions
    Natalie Andrew
    School of Biosciences, The University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
    Nat Cell Biol 9:193-200. 2007
    ....
  62. doi Centchroman induces G0/G1 arrest and caspase-dependent apoptosis involving mitochondrial membrane depolarization in MCF-7 and MDA MB-231 human breast cancer cells
    Manisha Nigam
    Tissue and Cell Culture Unit TCCU, Central Drug Research Institute, Lucknow, 226001, India
    Life Sci 82:577-90. 2008
    ..Results demonstrate that CC induces caspase-dependent apoptosis in MCF-7 and MDA MB-231 cells irrespective of ER status similar to TAM in terms of anti-neoplastic activity...
  63. pmc Tumor-derived endothelial cells exhibit aberrant Rho-mediated mechanosensing and abnormal angiogenesis in vitro
    Kaustabh Ghosh
    Vascular Biology Program, Departments of Pathology and Surgery, Children s Hospital and Harvard Medical School, Boston, MA 02115
    Proc Natl Acad Sci U S A 105:11305-10. 2008
    ....
  64. ncbi Distinct cis-regulatory elements from the Dlx1/Dlx2 locus mark different progenitor cell populations in the ganglionic eminences and different subtypes of adult cortical interneurons
    Noel Ghanem
    Centre for Advanced Research in Environmental Genomics, Department of Biology, University of Ottawa, Ottawa, Ontario, Canada K1N 6N5
    J Neurosci 27:5012-22. 2007
    ..These data suggest that interneuron subtypes use distinct combinations of Dlx1/Dlx2 enhancers from the time they are specified through adulthood...
  65. pmc Mechanism of shape determination in motile cells
    Kinneret Keren
    Department of Biochemistry, Technion Israel Institute of Technology, Haifa 32000, Israel
    Nature 453:475-80. 2008
    ..treadmilling in an inextensible membrane bag can quantitatively recapitulate this spectrum and predict both cell shape and speed...
  66. ncbi Tmod3 regulates polarized epithelial cell morphology
    Kari L Weber
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Cell Sci 120:3625-32. 2007
    ..Here, we show that the pointed-end capping protein Tmod3 contributes to epithelial cell shape within confluent monolayers of polarized epithelial cells...
  67. pmc Role of the RAM network in cell polarity and hyphal morphogenesis in Candida albicans
    Yunkyoung Song
    Department of Microbiology, School of Bioscience and Biotechnology, Chungnam National University, Daejeon 305 764, Korea
    Mol Biol Cell 19:5456-77. 2008
    ..Collectively, these results demonstrate that the RAM network is critically required for hyphal growth as well as normal vegetative growth in C. albicans...
  68. doi Modulation of stem cell shape and fate A: the role of density and seeding protocol on nucleus shape and gene expression
    Sara H McBride
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA
    Tissue Eng Part A 14:1561-72. 2008
    Mesenchymal stem cell shape and fate are intrinsic manifestations of form and function at the cellular level. We hypothesize that cell seeding density and initial seeding protocol influence stem cell shape and fate...
  69. ncbi Integrin-ECM interactions regulate the changes in cell shape driving the morphogenesis of the Drosophila wing epithelium
    Paloma Domínguez-Giménez
    Institut de Reserca Biomédica, Barcelona 08028, Spain
    J Cell Sci 120:1061-71. 2007
    ..wing epithelium to demonstrate that cell-ECM interactions mediated by integrins also regulate the changes in cell shape that underly epithelial morphogenesis...
  70. pmc The PIX-GIT complex: a G protein signaling cassette in control of cell shape
    Scott R Frank
    GI Cell Biology Laboratory, The Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Semin Cell Dev Biol 19:234-44. 2008
    ..A concept that emerges from the literature is that the PIX-GIT complex serves as a cassette to elicit changes in cell shape essential for polarized cell responses in a wide range of biological contexts.
  71. doi Cell shape and spreading of stromal (mesenchymal) stem cells cultured on fibronectin coated gold and hydroxyapatite surfaces
    A Dolatshahi-Pirouz
    Interdisciplinary Nanoscience Center iNANO, Aarhus University, Aarhus C, Denmark
    Colloids Surf B Biointerfaces 84:18-25. 2011
    ..In summary we find that fibronectin adsorbs in a more activated state on the HA surfaces, resulting in a slightly different cellular response as compared to the fibronectin coated Au surfaces...
  72. pmc Keeping the vimentin network under control: cell-matrix adhesion-associated plectin 1f affects cell shape and polarity of fibroblasts
    Gerald Burgstaller
    Department of Biochemistry and Cell Biology, Max F Perutz Laboratories, University of Vienna, A 1030 Vienna, Austria
    Mol Biol Cell 21:3362-75. 2010
    ..We show that the formation of this structure affects cell shape with consequences for cell polarization.
  73. pmc Endocytic and recycling endosomes modulate cell shape changes and tissue behaviour during morphogenesis in Drosophila
    Ana Margarida Mateus
    Department of Genetics, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 6:e18729. 2011
    ..We propose that the modulation of the balance between endocytosis and recycling can regulate cellular morphology and tissue deformations during morphogenesis...
  74. pmc Tao-1 is a negative regulator of microtubule plus-end growth
    Tao Liu
    MRC Laboratory for Molecular Cell Biology, University College London, London, WC1E 6BT, UK
    J Cell Sci 123:2708-16. 2010
    ..Through their ability to generate force and direct polar cell transport, microtubules help to organise global cell shape and polarity...
  75. doi Cells segmentation from 3-D confocal images of early zebrafish embryogenesis
    Cecilia Zanella
    DEIS, Bologna University, 40136 Bologna, Italy
    IEEE Trans Image Process 19:770-81. 2010
    ..the following steps: the signal-to-noise ratio is first improved by an edge-preserving filtering, then the cell shape is reconstructed applying a fully automated algorithm based on a generalized version of the Subjective Surfaces ..
  76. pmc Acellularization of embryoid bodies via physical disruption methods
    Alyssa V Ngangan
    The Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 313 Ferst Drive, Suite 2102, Atlanta, GA 30332 0535, USA
    Biomaterials 30:1143-9. 2009
    ....
  77. doi Rab8 GTPase as a regulator of cell shape
    Johan Peranen
    Institute of Biotechnology, University of Helsinki, Finland
    Cytoskeleton (Hoboken) 68:527-39. 2011
    ..A hypothesis is presented on the role of Rab8 in the formation of new cell surface domains. The review focuses on the function of Rab8 in cell migration, epithelial polarization, neuron differentiation, and ciliogenesis...
  78. pmc The determination of stem cell fate by 3D scaffold structures through the control of cell shape
    Girish Kumar
    Polymers Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA
    Biomaterials 32:9188-96. 2011
    ..Further, the effects of scaffold structure on hBMSC function were mediated by cell shape. Of all the scaffolds tested, only scaffolds with a nanofibrous morphology were able to drive the hBMSCs down an ..
  79. pmc Connecdenn 3/DENND1C binds actin linking Rab35 activation to the actin cytoskeleton
    Andrea L Marat
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Canada
    Mol Biol Cell 23:163-75. 2012
    ..This interaction couples Rab35 activation to the actin cytoskeleton, resulting in dramatic changes in cell shape, notably the formation of protrusive membrane extensions...
  80. ncbi Crosslinked chitosan: its physical properties and the effects of matrix stiffness on chondrocyte cell morphology and proliferation
    Anuradha Subramanian
    Department of Chemical Engineering, 207 Othmer Hall, University of Nebraska, Lincoln, NE 68588, USA
    J Biomed Mater Res A 75:742-53. 2005
    ..The cell morphology on crosslinked scaffolds seen by SEM and fluorescent stain was the typical chondrocytic rounded shape. The method proposed provides a nontoxic way to increase the mechanical strength of the chitosan scaffolds...
  81. doi Pob1 ensures cylindrical cell shape by coupling two distinct rho signaling events during secretory vesicle targeting
    Kentaro Nakano
    Department of Structural Biosciences, Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8577, Japan
    Traffic 12:726-39. 2011
    ..Thus, Pob1 may ensure cylindrical cell shape of S...
  82. pmc A novel pathway of TEF regulation mediated by microRNA-125b contributes to the control of actin distribution and cell shape in fibroblasts
    Olga Gutierrez
    Unidad de Genetica Molecular, Hospital Universitario Marques de Valdecilla, Instituto de Formación e Investigación Marqués de Valdecilla, Servicio Cantabro de Salud, Santander, Spain
    PLoS ONE 6:e17169. 2011
    ..In spite of its relevance, nothing is known about the regulation of TEF...
  83. doi Planar cell polarity pathway regulates actin rearrangement, cell shape, motility, and nephrin distribution in podocytes
    Sima Babayeva
    Department of Medicine, Nephrology Research Group, McGill University, Montreal, Quebec, Canada
    Am J Physiol Renal Physiol 300:F549-60. 2011
    ..Our observations indicate that PCP signaling may play an important role both in podocyte development and FP cytoskeleton dynamics...
  84. pmc Tropomodulin1 is required for membrane skeleton organization and hexagonal geometry of fiber cells in the mouse lens
    Roberta B Nowak
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Cell Biol 186:915-28. 2009
    ....
  85. pmc MAPK activation modulates permeability of isolated rat alveolar epithelial cell monolayers following cyclic stretch
    Taylor S Cohen
    Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 5:e10385. 2010
    ..These data suggest that stretch-induced JNK signaling modulates epithelial permeability through regulation tight junction protein expression, and is a potential target for clinical treatments during mechanical ventilation...
  86. doi Modulation of gene expression and collagen production of anterior cruciate ligament cells through cell shape changes on polycaprolactone/chitosan blends
    Hung Jen Shao
    Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan
    Biomaterials 31:4695-705. 2010
    ..We expected this concept, controlling the cell shape through biomaterial to modulate the behavior of cells, could provide a new vision for the material selection of ..
  87. ncbi p130-angiomotin associates to actin and controls endothelial cell shape
    Mira Ernkvist
    Department of Oncology Pathology, Cancer Centre Karolinska Institute, Stockholm, Sweden
    FEBS J 273:2000-11. 2006
    ..Transfection of p130-angiomotin into endothelial cells induces actin fiber formation and changes cell shape. The p130-angiomotin protein remained associated with actin after destabilization of actin fibers with ..
  88. doi ATP depletion alters the mode of cell death induced by benzyl isothiocyanate
    Noriyuki Miyoshi
    Laboratory of Biochemistry, Graduate School of Nutritional and Environmental Sciences, and Global COE Program, University of Shizuoka, Shizuoka 422 8526, Japan
    Biochim Biophys Acta 1782:566-73. 2008
    ..The obtained data suggested that the decline in the intracellular ATP level plays an important role in tuning the mode of cell death by BITC...
  89. pmc Structure of sterol aliphatic chains affects yeast cell shape and cell fusion during mating
    Pablo S Aguilar
    Departments of Biochemistry and Biophysics, Howard Hughes Medical Institute, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 107:4170-5. 2010
    ..Thus, a two-atom change in the aliphatic moiety of ergosterol is sufficient to obstruct cell shape remodeling and cell fusion.
  90. pmc Reinforcement of cell junctions correlates with the absence of hair cell regeneration in mammals and its occurrence in birds
    Joseph C Burns
    Department of Biomedical Engineering, University of Virginia School of Engineering and Applied Science, Charlottesville, Virginia 22908, USA
    J Comp Neurol 511:396-414. 2008
    ....
  91. doi Biology and physics of cell shape changes in development
    Ewa Paluch
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Curr Biol 19:R790-9. 2009
    Together with cell growth, division and death, changes in cell shape are of central importance for tissue morphogenesis during development. Cell shape is the product of a cell's material and active properties balanced by external forces...
  92. ncbi Cell distribution of stress fibres in response to the geometry of the adhesive environment
    Manuel Thery
    Biologie du cycle cellulaire et de la motilité, UMR144, CNRS, Institut Curie, Paris, France
    Cell Motil Cytoskeleton 63:341-55. 2006
    ..Adhesive micropatterns are commonly used to confine cell shape within a given geometry...
  93. ncbi The morphogenesis of lobed plant cells in the mesophyll and epidermis: organization and distinct roles of cortical microtubules and actin filaments
    Emmanuel Panteris
    University of Athens, Faculty of Biology, Department of Botany, Athens GR 15784, Greece
    New Phytol 167:721-32. 2005
    ..The genes that are possibly involved in the molecular regulation of the above morphogenetic procedure by MT and AF array organization are reviewed...
  94. ncbi C-Reactive protein-induced endothelial microparticle generation in HUVECs is related to BH4-dependent NO formation
    Jie mei Wang
    Department of Cardiology, First Affiliated Hospital, Sun Yat Sen University, Guangzhou, China
    J Vasc Res 44:241-8. 2007
    ..C-reactive protein (CRP) has been proven to facilitate endothelial injury via reduced NO production. Endothelial microparticles (EMPs) have emerged as a novel marker of endothelial injury...
  95. pmc Kinesin-1 heavy chain mediates microtubule sliding to drive changes in cell shape
    Amber L Jolly
    Department of Cell and Molecular Biology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 107:12151-6. 2010
    ..This provides the cell with a dedicated mechanism to transport long and short microtubule filaments and drive changes in cell shape.
  96. ncbi A mechanosensory system controls cell shape changes during mitosis
    Janet C Effler
    Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cell Cycle 6:30-5. 2007
    ..In this review, we summarize these findings and their implications for cytokinesis regulation and for understanding the cytoskeletal system architecture that governs shape control...
  97. doi Conical epidermal cells allow bees to grip flowers and increase foraging efficiency
    Heather M Whitney
    Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge CB2 3EA, UK
    Curr Biol 19:948-53. 2009
    ..used both biomimetic replicas of petal surfaces and isogenic Antirrhinum lines differing only in petal epidermal cell shape. We show that foraging bumblebees are able to discriminate between different surfaces via tactile cues alone...
  98. pmc Enabled and Capping protein play important roles in shaping cell behavior during Drosophila oogenesis
    Julie Gates
    Lineberger Comprehensive Cancer Center and Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Dev Biol 333:90-107. 2009
    ..Together these data reveal places that these actin regulators shape oogenesis...
  99. pmc Functional modulation of cardiac form through regionally confined cell shape changes
    Heidi J Auman
    Developmental Genetics Program and Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York, United States of America
    PLoS Biol 5:e53. 2007
    ..Focusing on the development of the ventricular chamber in zebrafish, we show that cardiomyocyte cell shape changes underlie the formation of characteristic chamber curvatures...
  100. doi Effect of cell shape and packing density on granulosa cell proliferation and formation of multiple layers during early follicle development in the ovary
    Patricia Da Silva-Buttkus
    Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    J Cell Sci 121:3890-900. 2008
    ..their proliferation and form multiple layers, providing a unique model for studying the relationship between cell shape, proliferation and multilayering within the context of two different intercommunicating cell types: somatic and ..
  101. doi Dynamic coordination of cytoskeletal and cell wall systems during plant cell morphogenesis
    Daniel B Szymanski
    Department of Agronomy, Lily Hall of Life Sciences, 915 West State Street, Purdue University, West Lafayette, IN 47907, USA
    Curr Biol 19:R800-11. 2009
    ..the mechanisms by which the cellular growth machinery and mechanical properties of the cell interact to dictate cell shape. The recent combined use of mutants, genomic analyses, sophisticated spectroscopies, and live cell imaging is ..

Research Grants95

  1. Peptidoglycan Biogenesis in Escherichia Coli
    Thomas G Bernhardt; Fiscal Year: 2010
    ..with a crosslinked polysaccharide polymer called peptidoglycan (PG) that is critical for the maintenance of cell shape and integrity...
  2. Blood Brain Barrier Physiology and HIV Dementia
    HOWARD GENDELMAN; Fiscal Year: 2007
    ..was paid to the spatial parameters of cell biophysiology, migration and the mechanisms underlying changes in cell shape and volume...
  3. DNA-crosslinked gels: New advanced biomaterials
    NOSHIR LANGRANA; Fiscal Year: 2006
    ..and, thus, represent a novel class of biomimatic materials that may shed light on the mechanical basis of cell shape stability...
  4. METABOLISM OF THE TRABECULAR MESHWORK
    David Epstein; Fiscal Year: 2000
    ..that the cells of the aqueous outflow pathway can modulate aqueous humor outflow resistance through changes in cell shape, contraction and attachment; that the cytoskeleton in outflow pathway cells (both the inner wall of Schlemm's ..
  5. Quantitative Analysis of Chemotactic Motility Cycle of Ameboid Cells
    JUAN CARLOS contact LASHERAS; Fiscal Year: 2010
    ..We and others have observed that a considerable portion of the changes in cell shape occurring during amoeboid migration are due to periodic repetitive events, which enables the use of conditional ..
  6. MOLECULAR ANALYSIS OF TREPONEMAL MOTILITY GENES
    RONALD LIMBERGER; Fiscal Year: 2002
    ..The periplasmic location of the flagellar filament, together with the cell shape, enables the spirochete to move through dense matrices that would inhibit most other bacteria and assists in ..
  7. MECHANISM OF RETROCORNEAL FIBROUS MEMBRANE
    EUNDUCK KAY; Fiscal Year: 2007
    ..major phenotypes are altered in corneal endothelial cells (CECs): cell proliferation is markedly stimulated; cell shape is changed and contact-inhibited phenotypes are lost; and fibrillar extracellular matrix is produced...
  8. The biomechanics of morphogenesis in the frog
    Lance A Davidson; Fiscal Year: 2010
    ..analysis of the mechanics of convergent extension, identifying biomechanical mechanisms that regulate cell shape and drive mediolateral cell behaviors, establish passive tissue properties such as stiffness as well as active ..
  9. A Mutagenic Study of Yeast Actin Conformational Changes
    PETER RUBENSTEIN; Fiscal Year: 2006
    Actin is involved in a number of processes including generation of contractile force, cell shape determination, cytokinesis, and determination of cell polarity...
  10. MYOSIN MOVEMENT IN VITRO--MOLECULAR CHARACTERIZATION
    James Spudich; Fiscal Year: 1999
    The molecular motor myosin plays crucial-roles in contraction and various forms of cell movement and changes in cell shape. Cytokinesis, directed cell migration by chemotaxis, capping of ligand-bound cell surface receptors, morphogenetic ..
  11. Molecular basis of ILK signaling in cell adhesion
    Jun Qin; Fiscal Year: 2007
    ..extracellular and intracellular compartments allows dynamic regulation of many cellular processes including cell shape change, migration, proliferation and differentiation...
  12. Structural Basis of Actin Cytoskeleton Dynamics
    Roberto Dominguez; Fiscal Year: 2009
    ..to many cellular functions, including mitosis, cell division, intracellular transport, and the control of cell shape and polarity...
  13. Cytoskeletal Regulation of Erythrocyte Glucose Transporter-1
    Athar H Chishti; Fiscal Year: 2010
    Spectrin-actin junctions play critical roles in both the maintenance of red blood cell shape and membrane properties. Their organization and linkage to the cell membrane is therefore of fundamental importance to erythrocyte physiology...
  14. Cytoskeletal Regulation of Erythrocyte Glucose Transporter-1
    Athar Chishti; Fiscal Year: 2009
    Spectrin-actin junctions play critical roles in both the maintenance of red blood cell shape and membrane properties. Their organization and linkage to the cell membrane is therefore of fundamental importance to erythrocyte physiology...
  15. Membrane skeleton regulation of cell shape and interactions in lens development
    Velia M Fowler; Fiscal Year: 2010
    ..RELEVANCE: This project seeks to elucidate the molecular basis for membrane skeleton regulation of lens fiber cell shape, interactions and ordered hexagonal packing, and how this contributes to maintenance of lens transparency and ..
  16. The Biochemical Basis for the Mechanics of Cytokinesis
    Douglas Robinson; Fiscal Year: 2007
    Cytokinesis is a dramatic example of a cell shape change during which the mechanical constriction of the contractile ring leads to cell separation at the end of mitosis...
  17. Cellular and Biochemical Studies of Myosin Assembly in Dictyostelium
    Thomas Egelhoff; Fiscal Year: 2009
    Myosin II plays fundamental roles in cytokinesis, cell migration, and cell shape changes during development...
  18. Cellular and Biochemical Studies of Myosin Assembly in Dictyostelium
    Thomas Egelhoff; Fiscal Year: 2009
    Myosin II plays fundamental roles in cytokinesis, cell migration, and cell shape changes during development...
  19. Intermediate filament cytoskeleton and cell shape in Caulobacter crescentus
    Christine Jacobs Wagner; Fiscal Year: 2006
    ..Knowing the basis for intermediate filament function may reveal how intermediate filament-based diseases develop, suggesting treatment strategies. ..
  20. Intermediate filament cytoskeleton and cell shape in Caulobacter crescentus
    Christine Jacobs Wagner; Fiscal Year: 2007
    ..Knowing the basis for intermediate filament function may reveal how intermediate filament-based diseases develop, suggesting treatment strategies. ..
  21. Intermediate filament cytoskeleton and cell shape in Caulobacter crescentus
    Christine Jacobs Wagner; Fiscal Year: 2009
    ..Knowing the basis for intermediate filament function may reveal how intermediate filament-based diseases develop, suggesting treatment strategies. ..
  22. Cell Shape Control of Migration on Biomaterials
    Chia Chi Ho; Fiscal Year: 2006
    ..A successful proof-of-principle demonstration of how cell shape, defined by the geometry of micropatterns, can be used to control the directional migration of cells on ..
  23. REGULATION OF INTEGRIN ALPHA 4 BETA 1
    Mark Ginsberg; Fiscal Year: 2005
    ..He will introduce these mutations into intact integrins, and examine their effects on cell migration, cell shape, and organization of the cytoskeleton...
  24. Thrombin signaling and HIV dementia
    Katherine Conant; Fiscal Year: 2006
    ..Activation of endothelial cell PARs has been linked to changes in cell shape, increased chemokine release, and increased adhesion molecule expression...
  25. SURGICAL WOUND REPAIR--ROLE OF A NEUROENDOTHELIAL AXIS
    Nicole Gibran; Fiscal Year: 2003
    ..P directly regulates endothelial cell transcription of neurotrophins or whether the changes in endothelial cell shape and cytoskeletal organization induced by substance P increase neurotrophin release...