Genomes and Genes
Summary: The quality of surface form or outline of CELLS.
Publications210 found, 100 shown here
- PGE(2) inhibition of TGF-beta1-induced myofibroblast differentiation is Smad-independent but involves cell shape and adhesion-dependent signalingPeedikayil E Thomas
Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI 48109 2200, USA
Am J Physiol Lung Cell Mol Physiol 293:L417-28. 2007..Rather, PGE(2) has dramatic effects on cell shape and cytoskeletal architecture and disrupts the formation of appropriate focal adhesions...
- In vitro differentiation of human mesenchymal stem cells on Ti6Al4V surfacesIsabella Tognarini
Department of Internal Medicine, Medical School, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
Biomaterials 29:809-24. 2008..In conclusion, adipose tissue is a promising autologous source of osteoblastic cells with important clinical implications for bone tissue engineering...
- Building the actin cytoskeleton: filopodia contribute to the construction of contractile bundles in the lamellaMaria Nemethova
Institute of Molecular Biotechnology, Austrian Academy of Sciences, Vienna 1030, Austria
J Cell Biol 180:1233-44. 2008..Comparable results were obtained with B16 melanoma cells. These and other findings support the idea that filaments generated in filopodia and lamellipodia for protrusion are recycled for seeding actomyosin arrays for use in retraction...
- Matrix elasticity directs stem cell lineage specificationAdam J Engler
Pennsylvania Muscle Institute, University of Pennsylvania, Philadelphia, 19104, USA
Cell 126:677-89. 2006..The results have significant implications for understanding physical effects of the in vivo microenvironment and also for therapeutic uses of stem cells...
- Tensional homeostasis and the malignant phenotypeMatthew J Paszek
Department of Bioengineering, University of Pennsylvania, Philadelphia, 19104, USA
Cancer Cell 8:241-54. 2005..Thus, ERK and Rho constitute part of an integrated mechanoregulatory circuit linking matrix stiffness to cytoskeletal tension through integrins to regulate tissue phenotype...
- Actin, a central player in cell shape and movementThomas D Pollard
Department of Molecular, Cellular and Developmental Biology, Yale University, Post Office Box 208103, New Haven, CT 06520 8103, USA
Science 326:1208-12. 2009..Comparisons of quantitative measurements of reactions in live cells with computer simulations of mathematical models will also help generate meaningful insights...
- Cell surface mechanics and the control of cell shape, tissue patterns and morphogenesisThomas Lecuit
Institute of Developmental Biology of Marseille Luminy, UMR6216 CNRS Université de la Méditerranée, Campus de Luminy Case 907, 13288 Marseille Cedex 09, France
Nat Rev Mol Cell Biol 8:633-44. 2007..However, how this information is processed to control cell shape and cell dynamics is an open area of investigation...
- Coordination of Rho GTPase activities during cell protrusionMatthias Machacek
Department of Cell Biology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, California 92037, USA
Nature 461:99-103. 2009....
- Local force and geometry sensing regulate cell functionsViola Vogel
Laboratory for Biologically Oriented Materials, Department of Materials, Swiss Federal Institute of Technology ETH, Zurich, Wolfgang Pauli Strasse 10, ETH Honggerberg, HCI F443, CH 8093 Zurich, Switzerland
Nat Rev Mol Cell Biol 7:265-75. 2006..Recent tissue scaffolds that have been engineered at the micro- and nanoscale level now enable better dissection of the mechanosensing, transduction and response mechanisms...
- Chemotaxis in shallow gradients is mediated independently of PtdIns 3-kinase by biased choices between random protrusionsNatalie Andrew
School of Biosciences, The University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
Nat Cell Biol 9:193-200. 2007....
- Cytoskeletal dynamics and supracellular organisation of cell shape fluctuations during dorsal closureGuy B Blanchard
Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
Development 137:2743-52. 2010..Our results suggest that cell shape fluctuations are a property of cells with low and increasing levels of apical myosin, and that medial and ..
- Bacterial actin MreB assembles in complex with cell shape protein RodZFusinita van den Ent
MRC Laboratory of Molecular Biology, Cambridge, UK
EMBO J 29:1081-90. 2010Bacterial actin homologue MreB is required for cell shape maintenance in most non-spherical bacteria, where it assembles into helical structures just underneath the cytoplasmic membrane...
- Emergence of large-scale cell morphology and movement from local actin filament growth dynamicsCatherine I Lacayo
Department of Biochemistry, Stanford University, Stanford, California, United States of America
PLoS Biol 5:e233. 2007..of natural cell-to-cell variation within a population by using measurable morphological and behavioral features--cell shape, leading-edge shape, filamentous actin (F-actin) distribution, cell speed, and directional persistence--that we ..
- The shape of motile cellsAlex Mogilner
Department of Neurobiology, Physiology and Behavior, University of California, Davis, CA 95616, USA
Curr Biol 19:R762-71. 2009..We start with geometric rules describing cell-edge kinetics that govern cell shape, followed by a discussion of the underlying biophysics; we consider actin treadmilling, actin-myosin contraction,..
- Hydrostatic pressure and the actomyosin cortex drive mitotic cell roundingMartin P Stewart
ETH Zurich, Department of Biosystems Science and Engineering, CH 4058 Basel, Switzerland
Nature 469:226-30. 2011..Thus, by locally modulating actomyosin-cortex-dependent surface tension and globally regulating osmotic pressure, cells can control their volume, shape and mechanical properties...
- Adhesion signaling - crosstalk between integrins, Src and RhoStephan Huveneers
Division of Toxicology, Leiden Amsterdam Center for Drug Research, Leiden University, 2300 RA Leiden, The Netherlands
J Cell Sci 122:1059-69. 2009..We also discuss how this signaling network can regulate a range of cellular processes that are important for normal tissue function and disease, including cell adhesion, spreading, migration and mechanotransduction...
- Apical constriction: a cell shape change that can drive morphogenesisJacob M Sawyer
Biology Department, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Dev Biol 341:5-19. 2010..b>Cell shape changes and tissue movements like these are at the core of many of the morphogenetic movements that shape animal ..
- Ordered patterns of cell shape and orientational correlation during spontaneous cell migrationYusuke T Maeda
Department of Physics, Graduate School of Science, The University of Tokyo, Tokyo, Japan
PLoS ONE 3:e3734. 2008..Yet little is known about how cells change their own shape and how cells coordinate the deformation and movement. Here, we investigated the mechanism of spontaneous cell migration by using computational analyses...
- Growth stimulation leads to cellular senescence when the cell cycle is blockedZoya N Demidenko
Oncotarget, Albany, New York, USA
Cell Cycle 7:3355-61. 2008..Inhibition of TOR partially prevented senescent phenotype caused by DOX. Thus growth stimulation coupled with cell cycle arrest leads to senescence, whereas quiescence (a condition with inactive TOR) prevents senescence...
- Pulsation and stabilization: contractile forces that underlie morphogenesisAdam C Martin
Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
Dev Biol 341:114-25. 2010Embryonic development involves global changes in tissue shape and architecture that are driven by cell shape changes and rearrangements within cohesive cell sheets...
- Dpp signalling orchestrates dorsal closure by regulating cell shape changes both in the amnioserosa and in the epidermisBeatriz García Fernández
Instituto Gulbenkian de Ciencia, Rua da Quinta Grande 6, 2780 156 Oeiras, Portugal
Mech Dev 124:884-97. 2007..Embryos defective in Dpp signalling display defects in AS cell shape changes, specifically in the reduction of their apical surface areas, leading to defective AS contraction...
- Vimentin induces changes in cell shape, motility, and adhesion during the epithelial to mesenchymal transitionMelissa G Mendez
Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
FASEB J 24:1838-51. 2010..cell lines, we show that the level of expression of vimentin IFs (VIFs) correlates with mesenchymal cell shape and motile behavior...
- Cell shape changes indicate a role for extrinsic tensile forces in Drosophila germ-band extensionLucy C Butler
Department of Physiology, Development and Neuroscience, University of Cambridge, UK
Nat Cell Biol 11:859-64. 2009..cell behaviours underlying tissue morphogenesis, we have continuously quantified cell intercalation and cell shape change during GBE...
- Shroom family proteins regulate gamma-tubulin distribution and microtubule architecture during epithelial cell shape changeChanjae Lee
Department of Molecular Cell and Developmental Biology, and Institute for Cellular and Molecular Biology, University of Texas, Austin, TX 78712, USA
Development 134:1431-41. 2007b>Cell shape changes require the coordination of actin and microtubule cytoskeletons...
- Cell surface- and rho GTPase-based auxin signaling controls cellular interdigitation in ArabidopsisTongda Xu
Center for Plant Cell Biology, Department of Botany and Plant Sciences, University of California, Riverside, CA 92521, USA
Cell 143:99-110. 2010..These findings reveal Rho GTPase-based auxin-signaling mechanisms, which modulate the spatial coordination of cell expansion across a field of cells...
- Keeping the vimentin network under control: cell-matrix adhesion-associated plectin 1f affects cell shape and polarity of fibroblastsGerald Burgstaller
Department of Biochemistry and Cell Biology, Max F Perutz Laboratories, University of Vienna, A 1030 Vienna, Austria
Mol Biol Cell 21:3362-75. 2010..We show that the formation of this structure affects cell shape with consequences for cell polarization.
- Morphology, cytoskeletal organization, and myosin dynamics of mouse embryonic fibroblasts cultured on nanofibrillar surfacesIjaz Ahmed
Department of Pharmacology, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
Mol Cell Biochem 301:241-9. 2007..These results provide further evidence that nanofibrillar surfaces offer a significantly different environment for cells than 2D substrates...
- An SK3 channel/nWASP/Abi-1 complex is involved in early neurogenesisStefan Liebau
Institute for Anatomy and Cell Biology, Ulm University, Ulm, Germany
PLoS ONE 6:e18148. 2011..This observation indicates that the rearrangement of the actin based cytoskeleton via membrane bound SK3-channels might selectively be controlled in defined micro compartments of the cell...
- Subunits of the chaperonin CCT interact with F-actin and influence cell shape and cytoskeletal assemblyKaren I Brackley
Department of Cell and Molecular Biology, Göteborgs Universitet, Medicinaregatan 9C, 405 30 Goteborg, Sweden
Exp Cell Res 316:543-53. 2010..Reducing levels of individual CCT subunits implicates CCTepsilon in influencing cell shape and reduced levels of this subunit limit the cells' ability to recover from microfilament depolymerization...
- Sculpting the bacterial cellWilliam Margolin
Department of Microbiology and Molecular Genetics, University of Texas Medical School at Houston, 6431 Fannin Street, Houston, TX 77030, USA
Curr Biol 19:R812-22. 2009..Other bacteria that lack MreB homologs or even cell walls use distinct cytoskeletal systems to maintain their distinct shapes. Here I review what is known about the mechanisms that determine the shape of prokaryotic cells...
- Local positive feedback regulation determines cell shape in root hair cellsSeiji Takeda
Department of Cell and Developmental Biology, John Innes Centre, Norwich NR4 7UH, UK
Science 319:1241-4. 2008..Because the location and stability of growth sites predict the ultimate form of a plant cell, our findings demonstrate how a positive feedback mechanism involving RHD2, ROS, and Ca2+ can determine cell shape.
- Isolation and characterization of resident mesenchymal stem cells in human glomeruliStefania Bruno
Department of Internal Medicine, Molecular Biotechnology Center and Research Center for Experimental Medicine CeRMS, University of Torino, Torino, Italy and Fresenius Medical Care, Bad Homburg, Germany
Stem Cells Dev 18:867-80. 2009..In conclusion, these results indicate the presence of a multipotent mesenchymal cell population resident in human glomeruli that may have a role in the physiological cell turnover and/or in response to glomerular injury...
- A dynamic stochastic model of frequency-dependent stress fiber alignment induced by cyclic stretchHui Ju Hsu
Department of Biomedical Engineering, Texas A and M University, College Station, Texas, United States of America
PLoS ONE 4:e4853. 2009..While there is much evidence that cells reorganize their SFs in response to matrix deformations, it is unclear how cells and their SFs determine their specific response to particular spatiotemporal changes in the matrix...
- Morphological and electrophysiological properties of GABAergic and non-GABAergic cells in the deep cerebellar nucleiMarylka Uusisaari
Laboratory for Neuronal Circuit Dynamics, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
J Neurophysiol 97:901-11. 2007..We conclude that GABAergic DCN neurons are specialized to convey phasic spike rate information, whereas tonic spike rate is more faithfully relayed by the large non-GABAergic cells...
- Mechanism of shape determination in motile cellsKinneret Keren
Department of Biochemistry, Technion Israel Institute of Technology, Haifa 32000, Israel
Nature 453:475-80. 2008..treadmilling in an inextensible membrane bag can quantitatively recapitulate this spectrum and predict both cell shape and speed...
- Tmod3 regulates polarized epithelial cell morphologyKari L Weber
Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
J Cell Sci 120:3625-32. 2007..Here, we show that the pointed-end capping protein Tmod3 contributes to epithelial cell shape within confluent monolayers of polarized epithelial cells...
- Pob1 ensures cylindrical cell shape by coupling two distinct rho signaling events during secretory vesicle targetingKentaro Nakano
Department of Structural Biosciences, Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8577, Japan
Traffic 12:726-39. 2011..Thus, Pob1 may ensure cylindrical cell shape of S...
- Stem cell shape regulates a chondrogenic versus myogenic fate through Rac1 and N-cadherinLin Gao
Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Stem Cells 28:564-72. 2010..Our previous work revealed that cell shape regulates hMSC commitment between osteoblasts and adipocytes through RhoA signaling...
- Reinforcement of cell junctions correlates with the absence of hair cell regeneration in mammals and its occurrence in birdsJoseph C Burns
Department of Biomedical Engineering, University of Virginia School of Engineering and Applied Science, Charlottesville, Virginia 22908, USA
J Comp Neurol 511:396-414. 2008....
- Structure of sterol aliphatic chains affects yeast cell shape and cell fusion during matingPablo S Aguilar
Departments of Biochemistry and Biophysics, Howard Hughes Medical Institute, University of California, San Francisco, CA 94158, USA
Proc Natl Acad Sci U S A 107:4170-5. 2010..Thus, a two-atom change in the aliphatic moiety of ergosterol is sufficient to obstruct cell shape remodeling and cell fusion.
- Modulation of gene expression and collagen production of anterior cruciate ligament cells through cell shape changes on polycaprolactone/chitosan blendsHung Jen Shao
Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan
Biomaterials 31:4695-705. 2010..We expected this concept, controlling the cell shape through biomaterial to modulate the behavior of cells, could provide a new vision for the material selection of ..
- ATP depletion alters the mode of cell death induced by benzyl isothiocyanateNoriyuki Miyoshi
Laboratory of Biochemistry, Graduate School of Nutritional and Environmental Sciences, and Global COE Program, University of Shizuoka, Shizuoka 422 8526, Japan
Biochim Biophys Acta 1782:566-73. 2008..The obtained data suggested that the decline in the intracellular ATP level plays an important role in tuning the mode of cell death by BITC...
- Crosslinked chitosan: its physical properties and the effects of matrix stiffness on chondrocyte cell morphology and proliferationAnuradha Subramanian
Department of Chemical Engineering, 207 Othmer Hall, University of Nebraska, Lincoln, NE 68588, USA
J Biomed Mater Res A 75:742-53. 2005..The cell morphology on crosslinked scaffolds seen by SEM and fluorescent stain was the typical chondrocytic rounded shape. The method proposed provides a nontoxic way to increase the mechanical strength of the chitosan scaffolds...
- A novel pathway of TEF regulation mediated by microRNA-125b contributes to the control of actin distribution and cell shape in fibroblastsOlga Gutierrez
Unidad de Genetica Molecular, Hospital Universitario Marques de Valdecilla, Instituto de Formación e Investigación Marqués de Valdecilla, Servicio Cantabro de Salud, Santander, Spain
PLoS ONE 6:e17169. 2011..In spite of its relevance, nothing is known about the regulation of TEF...
- p130-angiomotin associates to actin and controls endothelial cell shapeMira Ernkvist
Department of Oncology Pathology, Cancer Centre Karolinska Institute, Stockholm, Sweden
FEBS J 273:2000-11. 2006..Transfection of p130-angiomotin into endothelial cells induces actin fiber formation and changes cell shape. The p130-angiomotin protein remained associated with actin after destabilization of actin fibers with ..
- Planar cell polarity pathway regulates actin rearrangement, cell shape, motility, and nephrin distribution in podocytesSima Babayeva
Department of Medicine, Nephrology Research Group, McGill University, Montreal, Quebec, Canada
Am J Physiol Renal Physiol 300:F549-60. 2011..Our observations indicate that PCP signaling may play an important role both in podocyte development and FP cytoskeleton dynamics...
- Tropomodulin1 is required for membrane skeleton organization and hexagonal geometry of fiber cells in the mouse lensRoberta B Nowak
Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
J Cell Biol 186:915-28. 2009....
- Polar actomyosin contractility destabilizes the position of the cytokinetic furrowJakub Sedzinski
Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany
Nature 476:462-6. 2011..Whether polar forces influence cytokinetic cell shape and furrow positioning remains an open question...
- Biology and physics of cell shape changes in developmentEwa Paluch
Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
Curr Biol 19:R790-9. 2009Together with cell growth, division and death, changes in cell shape are of central importance for tissue morphogenesis during development. Cell shape is the product of a cell's material and active properties balanced by external forces...
- Cell distribution of stress fibres in response to the geometry of the adhesive environmentManuel Thery
Biologie du cycle cellulaire et de la motilité, UMR144, CNRS, Institut Curie, Paris, France
Cell Motil Cytoskeleton 63:341-55. 2006..Adhesive micropatterns are commonly used to confine cell shape within a given geometry...
- MAPK activation modulates permeability of isolated rat alveolar epithelial cell monolayers following cyclic stretchTaylor S Cohen
Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
PLoS ONE 5:e10385. 2010..These data suggest that stretch-induced JNK signaling modulates epithelial permeability through regulation tight junction protein expression, and is a potential target for clinical treatments during mechanical ventilation...
- Automated characterization of cell shape changes during amoeboid motility by skeletonizationYuan Xiong
Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD 21218, USA
BMC Syst Biol 4:33. 2010....
- C-Reactive protein-induced endothelial microparticle generation in HUVECs is related to BH4-dependent NO formationJie mei Wang
Department of Cardiology, First Affiliated Hospital, Sun Yat Sen University, Guangzhou, China
J Vasc Res 44:241-8. 2007..C-reactive protein (CRP) has been proven to facilitate endothelial injury via reduced NO production. Endothelial microparticles (EMPs) have emerged as a novel marker of endothelial injury...
- Kinesin-1 heavy chain mediates microtubule sliding to drive changes in cell shapeAmber L Jolly
Department of Cell and Molecular Biology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
Proc Natl Acad Sci U S A 107:12151-6. 2010..This provides the cell with a dedicated mechanism to transport long and short microtubule filaments and drive changes in cell shape.
- The morphogenesis of lobed plant cells in the mesophyll and epidermis: organization and distinct roles of cortical microtubules and actin filamentsEmmanuel Panteris
University of Athens, Faculty of Biology, Department of Botany, Athens GR-15784, Greece
New Phytol 167:721-32. 2005..The genes that are possibly involved in the molecular regulation of the above morphogenetic procedure by MT and AF array organization are reviewed...
- Functional modulation of cardiac form through regionally confined cell shape changesHeidi J Auman
Developmental Genetics Program and Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York, United States of America
PLoS Biol 5:e53. 2007..Focusing on the development of the ventricular chamber in zebrafish, we show that cardiomyocyte cell shape changes underlie the formation of characteristic chamber curvatures...
- Force transmission in migrating cellsMaxime F Fournier
Laboratoire de Biophysique Cellulaire, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
J Cell Biol 188:287-97. 2010....
- Dynamic coordination of cytoskeletal and cell wall systems during plant cell morphogenesisDaniel B Szymanski
Department of Agronomy, Lily Hall of Life Sciences, 915 West State Street, Purdue University, West Lafayette, IN 47907, USA
Curr Biol 19:R800-11. 2009..the mechanisms by which the cellular growth machinery and mechanical properties of the cell interact to dictate cell shape. The recent combined use of mutants, genomic analyses, sophisticated spectroscopies, and live cell imaging is ..
- Enabled and Capping protein play important roles in shaping cell behavior during Drosophila oogenesisJulie Gates
Lineberger Comprehensive Cancer Center and Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Dev Biol 333:90-107. 2009..Together these data reveal places that these actin regulators shape oogenesis...
- Conical epidermal cells allow bees to grip flowers and increase foraging efficiencyHeather M Whitney
Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge CB2 3EA, UK
Curr Biol 19:948-53. 2009..used both biomimetic replicas of petal surfaces and isogenic Antirrhinum lines differing only in petal epidermal cell shape. We show that foraging bumblebees are able to discriminate between different surfaces via tactile cues alone...
- Computational model for cell morphodynamicsDanying Shao
Center for Theoretical Biological Physics and Department of Physics, University of California, San Diego, La Jolla, California 92093 0374, USA
Phys Rev Lett 105:108104. 2010..Furthermore, we find that the dependence of the cell speed on this aspect ratio matches experimentally observed data...
- A mechanosensory system controls cell shape changes during mitosisJanet C Effler
Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Cell Cycle 6:30-5. 2007..In this review, we summarize these findings and their implications for cytokinesis regulation and for understanding the cytoskeletal system architecture that governs shape control...
- Effect of cell shape and packing density on granulosa cell proliferation and formation of multiple layers during early follicle development in the ovaryPatricia Da Silva-Buttkus
Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
J Cell Sci 121:3890-900. 2008..their proliferation and form multiple layers, providing a unique model for studying the relationship between cell shape, proliferation and multilayering within the context of two different intercommunicating cell types: somatic and ..
- Two distinct modes of myosin assembly and dynamics during epithelial wound closureMasako Tamada
Department of Biological Sciences, Columbia University, New York, NY 10027, USA
J Cell Biol 176:27-33. 2007..Thus, we suggest that tight junctions serve as attachment points for the actomyosin ring during wound closure and that Rho-kinase is required for localization and activation of the contractile ring...
- Rapid leukocyte migration by integrin-independent flowing and squeezingTim Lämmermann
Department of Molecular Medicine, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
Nature 453:51-5. 2008..Myosin II-dependent contraction is only required on passage through narrow gaps, where a squeezing contraction of the trailing edge propels the rigid nucleus...
- Inhibition by Rho-kinase and protein kinase C of myosin phosphatase is involved in thrombin-induced shape change of megakaryocytic leukemia cell line UT-7/TPOAkira Yazaki
The 2nd Department of Internal Medicine, Mie University School of Medicine, Mie 514-8507, Japan
Cell Signal 17:321-30. 2005....
- Compartmentalized morphogenesis in epithelia: from cell to tissue shapeFanny Pilot
, , , Marseille, France
Dev Dyn 232:685-94. 2005..Basolateral protrusive activity underlies other cases of intercalation. These localized cell shape changes are spatially regulated by developmental signals. Some signals define a local change in cell behavior (e...
- Actin-myosin network reorganization breaks symmetry at the cell rear to spontaneously initiate polarized cell motilityPatricia T Yam
Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA
J Cell Biol 178:1207-21. 2007..Together, these results indicate that large-scale actin-myosin network reorganization and contractility at the cell rear initiate spontaneous symmetry breaking and polarized motility of keratocytes...
- Transformation of adult rat cardiac myocytes in primary cultureTamas Banyasz
University of Kentucky, 741 South Limestone Street, Lexington, KY 40536 0509, USA
Exp Physiol 93:370-82. 2008..The results of the viability assays indicate that these alterations could not be attributed to either apoptosis or necrosis but are rather an adaptation to the culture conditions over time...
- Growth cone steering by a physiological electric field requires dynamic microtubules, microfilaments and Rac-mediated filopodial asymmetryAnn M Rajnicek
School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen, Scotland, AB25 2ZD, UK
J Cell Sci 119:1736-45. 2006..Understanding the mechanism for cathodal growth cone guidance will enhance the emerging clinical effort to stimulate human spinal cord regeneration through EF application...
- Tools for analyzing cell shape changes during chemotaxisYuan Xiong
Department of Electrical and Computer Engineering, The Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218, USA
Integr Biol (Camb) 2:561-7. 2010..understanding of the chemotactic response of amoebae and neutrophils requires careful quantification of the cell shape changes observed during cell movement...
- Bves directly interacts with GEFT, and controls cell shape and movement through regulation of Rac1/Cdc42 activityT K Smith
The Stahlman Cardiovascular Research Laboratories, Program for Developmental Biology, and Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 6300, USA
Proc Natl Acad Sci U S A 105:8298-303. 2008..Therefore, we propose Bves as a novel regulator of the Rac1 and Cdc42 signaling cascades...
- Cell shape-dependent Control of Ca2+ influx and cell cycle progression in Swiss 3T3 fibroblastsStephen R Pennington
Department of Human Anatomy and Cell Biology, School of Biomedical Sciences, University of Liverpool, Sherrington Buildings, Ashton Street, Liverpool L69 3GE, United Kingdom
J Biol Chem 282:32112-20. 2007..The effect of cell shape on mitogen-evoked Ca2+ signaling events that accompany entry into the cell cycle was investigated...
- The modified flavonol glycosylation profile in the Arabidopsis rol1 mutants results in alterations in plant growth and cell shape formationChristoph Ringli
Institute of Plant Biology, University of Zurich, 8008 Zurich, Switzerland
Plant Cell 20:1470-81. 2008..Together, these results suggest that changes in the composition of flavonols can have a tremendous impact on plant development through both auxin-induced and auxin-independent processes...
- Zona pellucida domain proteins remodel the apical compartment for localized cell shape changesIsabelle Fernandes
Universite de Toulouse, UPS, Centre de Biologie du Developpement, F 31062, Toulouse, France
Dev Cell 18:64-76. 2010..conservation, these ZPD proteins exert specific and nonredundant functions in the remodeling of epidermal cell shape. Each one accumulates in a restricted subregion of the apical compartment, where it organizes local interactions ..
- Molecular mechanisms controlling pavement cell shape in Arabidopsis leavesPingping Qian
Key Laboratory of Arid and Grassland Ecology, Ministry of Education, School of Life Science, Lanzhou University, 730000, Gansu, China
Plant Cell Rep 28:1147-57. 2009..The mutations of these genes through various means lead to pavement cell shape defects, such as loss or lack of interdigitation, the reduction of lobing, gaps between lobe and neck regions in ..
- Microtubule organization: cell shape is destinySteven B Haase
Biology Department, Duke University, Durham, NC 27710, USA
Curr Biol 17:R249-51. 2007..The cylindrical cell shape automatically corrects spindle orientation errors, rendering a checkpoint unnecessary.
- Lysophosphatidic acid stimulation of platelets rapidly induces Ca2+-dependent dephosphorylation of cofilin that is independent of dense granule secretion and aggregationDharmendra Pandey
Institute for Prevention of Cardiovascular Diseases, Klinikum Innenstadt, University of Munich, Pettenkoferstrasse 9, D 80336 Munich, Germany
Blood Cells Mol Dis 38:269-79. 2007..However, a rapid dephosphorylation of cofilin occurs during secretion and aggregation, which is Ca(2+)-dependent, upstream of secretion and aggregation and might regulate these platelet responses...
- A default mechanism of spindle orientation based on cell shape is sufficient to generate cell fate diversity in polarised Xenopus blastomeresBernhard Strauss
The Wellcome Trust/Cancer Research UK Gurdon Institute, Cambridge, UK
Development 133:3883-93. 2006..These results show that a mechanism of spindle orientation that depends on cell shape rather than cortical polarity can nevertheless generate cell fate diversity from a population of polarised cells.
- Plant cells taking shape: new insights into cytoplasmic controlDaniel B Szymanski
Purdue University, Department of Agronomy, 1150 Lily Hall, W Lafayette, United States
Curr Opin Plant Biol 12:735-44. 2009The slow and irreversible changes in plant cell shape include the cytoplasmic control of cell wall yielding in response to turgor pressure and the genesis of intracellular trafficking routes to the cell cortex...
- Regulation of cell shape, wing hair initiation and the actin cytoskeleton by Trc/Fry and Wts/Mats complexesXiaolan Fang
Department of Biology, University of Virginia, Charlottesville, VA 22903, USA
Dev Biol 341:360-74. 2010..Mutations in these genes lead to changes in cell shape, cellular levels of F-actin, the timing of differentiation, and the expression of multiple wing hairs and DE-..
- Effects of novel ethacrynic acid derivatives on human trabecular meshwork cell shape, actin cytoskeletal organization, and transcellular fluid flowPonugoti Vasantha Rao
Department of Ophthalmology, Duke University School of Medicine, Durham, NC 27710, USA
Biol Pharm Bull 28:2189-96. 2005..a comparative evaluation of the dose-dependent effects of these compounds on human trabecular meshwork (HTM) cell shape, actin cytoskeletal organization, focal adhesions and transcellular fluid flow...
- Molecular dissection of PINCH-1 reveals a mechanism of coupling and uncoupling of cell shape modulation and survivalZhen Xu
Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
J Biol Chem 280:27631-7. 2005..focal adhesion protein with multiple functions including regulation of the integrin-linked kinase (ILK) level, cell shape, and survival signaling...
- Round versus flat: bone cell morphology, elasticity, and mechanosensingRommel G Bacabac
Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam UvA and Vrije Universiteit, Amsterdam, The Netherlands
J Biomech 41:1590-8. 2008..Our assay provides novel opportunities for in vitro studies under a controlled suspended morphology versus commonly studied adherent morphologies...
- GPR92/LPA₅ lysophosphatidate receptor mediates megakaryocytic cell shape change induced by human atherosclerotic plaquesAnna L Khandoga
Institute for Prevention of Cardiovascular Diseases, University of Munich, Munich, Germany
Cardiovasc Res 90:157-64. 2011..The aim of our study was to identify the functional LPA receptor(s) in human platelets by silencing individual LPA receptors in megakaryocytic (MK) cells...
- Determining the contribution of epidermal cell shape to petal wettability using isogenic Antirrhinum linesHeather M Whitney
Department of Plant Sciences, University of Cambridge, Cambridge, United Kingdom
PLoS ONE 6:e17576. 2011..We discuss how the petal epidermis is a highly multifunctional one and how a battery of methods, including the use of isogenic lines, is required to untangle the impacts of specific epidermal properties in an ecological context...
- Induced pluripotent cells mimicking human embryonic stem cellsMehdi Mohamadnejad
Digestive Disease Research Center, Medical Sciences/ University of Tehran, Tehran, Iran
Arch Iran Med 11:125-8. 2008
- Comparative in vitro and in vivo studies using a bioactive poly(epsilon-caprolactone)-organosiloxane nanohybrid containing calcium saltJeong Joon Yoo
Department of Orthopedic Surgery, College of Medicine, Seoul National University, Yeongeon 28, Jongno, Seoul 110 744, Korea
J Biomed Mater Res B Appl Biomater 83:189-98. 2007..Our results suggest that precoating the apatite layer before in vitro testing is desirable for bioactive materials that release calcium quickly and in large amount because this treatment can more closely mimic in vivo events...
- In vitro cardiomyogenic differentiation of adult human bone marrow mesenchymal stem cells. The role of 5-azacytidinePolychronis Antonitsis
First Department of Thoracic and Cardiovascular Surgery, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece
Interact Cardiovasc Thorac Surg 6:593-7. 2007..These results indicate that adult human bone marrow mesenchymal stem cells can differentiate towards a cardiomyogenic lineage in vitro...
- RhoB affects macrophage adhesion, integrin expression and migrationAnn P Wheeler
Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, London, UK
Exp Cell Res 313:3505-16. 2007..Since macrophages do not express RhoC, these effects of C3 transferase are due to inhibition of RhoA rather than RhoB. Our results suggest that RhoB affects cell shape and migration by regulating surface integrin levels.
- Attenuation of retinal endothelial cell migration and capillary morphogenesis in the absence of bcl-2Shuji Kondo
Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792 4108, USA
Am J Physiol Cell Physiol 294:C1521-30. 2008..Thus, bcl-2-mediated cellular functions play important roles not only in survival but also in proangiogenic phenotype of EC with a significant impact on vascular development and angiogenesis...
- In vitro characterization of a murine oligodendrocyte precursor cell line (BO-1) following spontaneous immortalizationKidsadagon Pringproa
Institute of Pathology, University of Veterinary Medicine Hannover, Hannover, Germany
Int J Dev Neurosci 26:283-91. 2008..In summary, the novel murine BO-1 cell line shares several characteristics with oligodendrocyte precursor cells but displays a restricted differentiation into mature oligodendrocytes...
- The effect of silica nanoparticle-modified surfaces on cell morphology, cytoskeletal organization and functionAnna M Lipski
Department of Materials Science and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA
Biomaterials 29:3836-46. 2008....
- Inhibition of Src and p38 MAP kinases suppresses the change of claudin expression induced on dedifferentiation of primary cultured parotid acinar cellsJunko Fujita-Yoshigaki
Dept of Physiology, Nihon Univ School of Dentistry at Matsudo, Sakaecho nishi 2 870 1, Matsudo, Chiba 271 8587, Japan
Am J Physiol Cell Physiol 294:C774-85. 2008..Therefore, cellular stresses induced during cell isolation cause dedifferentiation and transition to duct-like cells through activation of p38 MAP kinase and constitutively active Src kinases...
- Discerning the role of topography and ion exchange in cell response of bioactive tissue engineering scaffoldsElisabeth Engel
Biomaterials, Biomechanics, and Tissue Engineering Group, Department of Materials Science and Metallurgy, Technical University of Catalonia, Barcelona, Spain
Tissue Eng Part A 14:1341-51. 2008..Cell differentiation was strongly enhanced when cells were cultured on the finer substrate. This effect was not explained by the chemical modification of the medium, but rather suggested a strictly topographical effect...
- Effect of nitride film coatings on cell compatibilityChia Chi Chien
Institute of Oral Biology, National Yang Ming University, Taipei, Taiwan
Dent Mater 24:986-93. 2008..To evaluate the cytotoxicity of nickel-based alloy surfaces after nitride film coatings...
- Opposite effects of overexpressed myosin Va or heavy meromyosin Va on vesicle distribution, cytoskeleton organization, and cell motility in nonmuscle cellsRobbin D Eppinga
Department of Biological Sciences, University of Iowa, Iowa City, Iowa 52242 1324, USA
Cell Motil Cytoskeleton 65:197-215. 2008..Together, these data suggest that myosin Va overexpression induces actin bundles in vivo whereas the tailless version fails to bundle actin and disrupts cell motility...
- Arf6 and microtubules in adhesion-dependent trafficking of lipid raftsNagaraj Balasubramanian
Robert M Beirne Cardiovascular Research Center, Mellon Prostate Cancer Research Institute, University of Virginia, Charlottesville, Virginia 22908, USA
Nat Cell Biol 9:1381-91. 2007..Both of these steps are required for the plasma membrane targeting of Rac1 and for its activation. These data therefore define a new membrane raft trafficking pathway that is crucial for anchorage-dependent signalling...
- Cell adhesion resistance mechanisms using arrays of dextran-derivative layersEmmanuelle Monchaux
Laboratoire de Bioingenierie et de Biophysique de l Universite de Sherbrooke, Department of Chemical Engineering, Universite de Sherbrooke, 2500, boulevard de l Université, Sherbrooke, Quebec, Canada, J1K 2R1
J Biomed Mater Res A 85:1052-63. 2008..Finally, an optimized CMD layer was chosen and proved to be as resistant as a poly(ethylene glycol) layer...
- Phenotypic and functional differences between human liver cancer endothelial cells and liver sinusoidal endothelial cellsLian Qiu Wu
Institute of Clinical Medical Sciences, China Japan Friendship Hospital, Beijing, PR China
J Vasc Res 45:78-86. 2008..The phenotypic and functional characteristics of microvascular endothelial cells derived from human liver cancer (HLCEC) were analyzed in vitro and compared with those of human liver sinusoidal endothelial cells (LSEC)...
- Sonic hedgehog induces transcription-independent cytoskeletal rearrangement and migration regulated by arachidonate metabolitesMaarten F Bijlsma
Center for Experimental and Molecular Medicine, Room G2 105, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Cell Signal 19:2596-604. 2007....
- Peptidoglycan Biogenesis in Escherichia ColiThomas G Bernhardt; Fiscal Year: 2010..with a crosslinked polysaccharide polymer called peptidoglycan (PG) that is critical for the maintenance of cell shape and integrity...
- Blood Brain Barrier Physiology and HIV DementiaHOWARD GENDELMAN; Fiscal Year: 2007..was paid to the spatial parameters of cell biophysiology, migration and the mechanisms underlying changes in cell shape and volume...
- DNA-crosslinked gels: New advanced biomaterialsNOSHIR LANGRANA; Fiscal Year: 2006..and, thus, represent a novel class of biomimatic materials that may shed light on the mechanical basis of cell shape stability...
- METABOLISM OF THE TRABECULAR MESHWORKDavid Epstein; Fiscal Year: 2000..that the cells of the aqueous outflow pathway can modulate aqueous humor outflow resistance through changes in cell shape, contraction and attachment; that the cytoskeleton in outflow pathway cells (both the inner wall of Schlemm's ..
- Quantitative Analysis of Chemotactic Motility Cycle of Ameboid CellsJUAN CARLOS contact LASHERAS; Fiscal Year: 2010..We and others have observed that a considerable portion of the changes in cell shape occurring during amoeboid migration are due to periodic repetitive events, which enables the use of conditional ..
- MOLECULAR ANALYSIS OF TREPONEMAL MOTILITY GENESRONALD LIMBERGER; Fiscal Year: 2002..The periplasmic location of the flagellar filament, together with the cell shape, enables the spirochete to move through dense matrices that would inhibit most other bacteria and assists in ..
- MECHANISM OF RETROCORNEAL FIBROUS MEMBRANEEUNDUCK KAY; Fiscal Year: 2007..major phenotypes are altered in corneal endothelial cells (CECs): cell proliferation is markedly stimulated; cell shape is changed and contact-inhibited phenotypes are lost; and fibrillar extracellular matrix is produced...
- The biomechanics of morphogenesis in the frogLance A Davidson; Fiscal Year: 2010..analysis of the mechanics of convergent extension, identifying biomechanical mechanisms that regulate cell shape and drive mediolateral cell behaviors, establish passive tissue properties such as stiffness as well as active ..
- A Mutagenic Study of Yeast Actin Conformational ChangesPETER RUBENSTEIN; Fiscal Year: 2006Actin is involved in a number of processes including generation of contractile force, cell shape determination, cytokinesis, and determination of cell polarity...
- MYOSIN MOVEMENT IN VITRO--MOLECULAR CHARACTERIZATIONJames Spudich; Fiscal Year: 1999The molecular motor myosin plays crucial-roles in contraction and various forms of cell movement and changes in cell shape. Cytokinesis, directed cell migration by chemotaxis, capping of ligand-bound cell surface receptors, morphogenetic ..
- Structural Basis of Actin Cytoskeleton DynamicsRoberto Dominguez; Fiscal Year: 2009..to many cellular functions, including mitosis, cell division, intracellular transport, and the control of cell shape and polarity...
- Molecular basis of ILK signaling in cell adhesionJun Qin; Fiscal Year: 2007..extracellular and intracellular compartments allows dynamic regulation of many cellular processes including cell shape change, migration, proliferation and differentiation...
- Membrane skeleton regulation of cell shape and interactions in lens developmentVelia M Fowler; Fiscal Year: 2010..RELEVANCE: This project seeks to elucidate the molecular basis for membrane skeleton regulation of lens fiber cell shape, interactions and ordered hexagonal packing, and how this contributes to maintenance of lens transparency and ..
- Cytoskeletal Regulation of Erythrocyte Glucose Transporter-1Athar H Chishti; Fiscal Year: 2010Spectrin-actin junctions play critical roles in both the maintenance of red blood cell shape and membrane properties. Their organization and linkage to the cell membrane is therefore of fundamental importance to erythrocyte physiology...
- Cytoskeletal Regulation of Erythrocyte Glucose Transporter-1Athar Chishti; Fiscal Year: 2009Spectrin-actin junctions play critical roles in both the maintenance of red blood cell shape and membrane properties. Their organization and linkage to the cell membrane is therefore of fundamental importance to erythrocyte physiology...
- The Biochemical Basis for the Mechanics of CytokinesisDouglas Robinson; Fiscal Year: 2007Cytokinesis is a dramatic example of a cell shape change during which the mechanical constriction of the contractile ring leads to cell separation at the end of mitosis...
- Cellular and Biochemical Studies of Myosin Assembly in DictyosteliumThomas Egelhoff; Fiscal Year: 2009Myosin II plays fundamental roles in cytokinesis, cell migration, and cell shape changes during development...
- Cellular and Biochemical Studies of Myosin Assembly in DictyosteliumThomas Egelhoff; Fiscal Year: 2009Myosin II plays fundamental roles in cytokinesis, cell migration, and cell shape changes during development...
- Intermediate filament cytoskeleton and cell shape in Caulobacter crescentusChristine Jacobs Wagner; Fiscal Year: 2006..Knowing the basis for intermediate filament function may reveal how intermediate filament-based diseases develop, suggesting treatment strategies. ..
- Intermediate filament cytoskeleton and cell shape in Caulobacter crescentusChristine Jacobs Wagner; Fiscal Year: 2007..Knowing the basis for intermediate filament function may reveal how intermediate filament-based diseases develop, suggesting treatment strategies. ..
- Intermediate filament cytoskeleton and cell shape in Caulobacter crescentusChristine Jacobs Wagner; Fiscal Year: 2009..Knowing the basis for intermediate filament function may reveal how intermediate filament-based diseases develop, suggesting treatment strategies. ..
- Cell Shape Control of Migration on BiomaterialsChia Chi Ho; Fiscal Year: 2006..A successful proof-of-principle demonstration of how cell shape, defined by the geometry of micropatterns, can be used to control the directional migration of cells on ..
- REGULATION OF INTEGRIN ALPHA 4 BETA 1Mark Ginsberg; Fiscal Year: 2005..He will introduce these mutations into intact integrins, and examine their effects on cell migration, cell shape, and organization of the cytoskeleton...
- SURGICAL WOUND REPAIR--ROLE OF A NEUROENDOTHELIAL AXISNicole Gibran; Fiscal Year: 2003..P directly regulates endothelial cell transcription of neurotrophins or whether the changes in endothelial cell shape and cytoskeletal organization induced by substance P increase neurotrophin release...
- Thrombin signaling and HIV dementiaKatherine Conant; Fiscal Year: 2006..Activation of endothelial cell PARs has been linked to changes in cell shape, increased chemokine release, and increased adhesion molecule expression...