cell death


Summary: The termination of the cell's ability to carry out vital functions such as metabolism, growth, reproduction, responsiveness, and adaptability.

Top Publications

  1. pmc Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009
    G Kroemer
    INSERM, U848, Villejuif F 94805, France
    Cell Death Differ 16:3-11. 2009
  2. ncbi Cell death: critical control points
    Nika N Danial
    Howard Hughes Medical Institute, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Cell 116:205-19. 2004
  3. pmc Autophagy in the pathogenesis of disease
    Beth Levine
    Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Cell 132:27-42. 2008
  4. ncbi Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury
    Alexei Degterev
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Chem Biol 1:112-9. 2005
  5. pmc p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
    Geir Bjørkøy
    Biochemistry Department, Institute of Medical Biology, University of Tromsø, 9037 Tromsø, Norway
    J Cell Biol 171:603-14. 2005
  6. ncbi Development by self-digestion: molecular mechanisms and biological functions of autophagy
    Beth Levine
    Department of Medicine, Columbia University, New York, NY 10032, USA
    Dev Cell 6:463-77. 2004
  7. pmc Novel cell death program leads to neutrophil extracellular traps
    Tobias A Fuchs
    Department for Cellular Microbiology, Max Planck Institute for Infection Biology, 10117 Berlin, Germany
    J Cell Biol 176:231-41. 2007
  8. pmc Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection
    Gilad Doitsh
    1 Gladstone Institute of Virology and Immunology, 1650 Owens Street, San Francisco, California 94158, USA 2
    Nature 505:509-14. 2014
  9. pmc Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders
    Giles E Hardingham
    Centre for Integrative Physiology, University of Edinburgh, School of Biomedical Sciences, Hugh Robson Building, Edinburgh EH8 9XD, UK
    Nat Rev Neurosci 11:682-96. 2010
  10. ncbi Loss of autophagy in the central nervous system causes neurodegeneration in mice
    Masaaki Komatsu
    Laboratory of Frontier Science, Tokyo Metropolitan Institute of Medical Science, Bunkyo ku, Tokyo 113 8613, Japan
    Nature 441:880-4. 2006

Detail Information

Publications359 found, 100 shown here

  1. pmc Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009
    G Kroemer
    INSERM, U848, Villejuif F 94805, France
    Cell Death Differ 16:3-11. 2009
    Different types of cell death are often defined by morphological criteria, without a clear reference to precise biochemical mechanisms...
  2. ncbi Cell death: critical control points
    Nika N Danial
    Howard Hughes Medical Institute, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Cell 116:205-19. 2004
    Programmed cell death is a distinct genetic and biochemical pathway essential to metazoans. An intact death pathway is required for successful embryonic development and the maintenance of normal tissue homeostasis...
  3. pmc Autophagy in the pathogenesis of disease
    Beth Levine
    Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Cell 132:27-42. 2008
    ..This Review summarizes recent advances in understanding the physiological functions of autophagy and its possible roles in the causation and prevention of human diseases...
  4. ncbi Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury
    Alexei Degterev
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Chem Biol 1:112-9. 2005
    ..been extensively characterized over the past decade, but little is known about alternative forms of regulated cell death. Although stimulation of the Fas/TNFR receptor family triggers a canonical 'extrinsic' apoptosis pathway, we ..
  5. pmc p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
    Geir Bjørkøy
    Biochemistry Department, Institute of Medical Biology, University of Tromsø, 9037 Tromsø, Norway
    J Cell Biol 171:603-14. 2005
    ..Reduction of p62 protein levels or interference with p62 function significantly increased cell death that was induced by the expression of mutant huntingtin...
  6. ncbi Development by self-digestion: molecular mechanisms and biological functions of autophagy
    Beth Levine
    Department of Medicine, Columbia University, New York, NY 10032, USA
    Dev Cell 6:463-77. 2004
    ..eukaryotic organisms and in multiple different cell types during starvation, cellular and tissue remodeling, and cell death. However, until recently, the functions of autophagy in normal development were largely unknown...
  7. pmc Novel cell death program leads to neutrophil extracellular traps
    Tobias A Fuchs
    Department for Cellular Microbiology, Max Planck Institute for Infection Biology, 10117 Berlin, Germany
    J Cell Biol 176:231-41. 2007
    ..Finally, the NETs are released as the cell membrane breaks. This cell death process is distinct from apoptosis and necrosis and depends on the generation of reactive oxygen species (ROS) ..
  8. pmc Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection
    Gilad Doitsh
    1 Gladstone Institute of Virology and Immunology, 1650 Owens Street, San Francisco, California 94158, USA 2
    Nature 505:509-14. 2014
    The pathway causing CD4 T-cell death in HIV-infected hosts remains poorly understood although apoptosis has been proposed as a key mechanism...
  9. pmc Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders
    Giles E Hardingham
    Centre for Integrative Physiology, University of Edinburgh, School of Biomedical Sciences, Hugh Robson Building, Edinburgh EH8 9XD, UK
    Nat Rev Neurosci 11:682-96. 2010
    ..leads to the build-up of a neuroprotective 'shield', whereas stimulation of extrasynaptic NMDARs promotes cell death. These differences result from the activation of distinct genomic programmes and from opposing actions on ..
  10. ncbi Loss of autophagy in the central nervous system causes neurodegeneration in mice
    Masaaki Komatsu
    Laboratory of Frontier Science, Tokyo Metropolitan Institute of Medical Science, Bunkyo ku, Tokyo 113 8613, Japan
    Nature 441:880-4. 2006
    ..Our results indicate that autophagy is essential for the survival of neural cells, and that impairment of autophagy is implicated in the pathogenesis of neurodegenerative disorders involving ubiquitin-containing inclusion bodies...
  11. doi Molecular mechanisms of necroptosis: an ordered cellular explosion
    Peter Vandenabeele
    Department for Molecular Biomedical Research, VIB, Ghent University, Belgium
    Nat Rev Mol Cell Biol 11:700-14. 2010
    For a long time, apoptosis was considered the sole form of programmed cell death during development, homeostasis and disease, whereas necrosis was regarded as an unregulated and uncontrollable process...
  12. pmc Mitochondria and the autophagy-inflammation-cell death axis in organismal aging
    Douglas R Green
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Science 333:1109-12. 2011
    ..Thus, a combination of mitochondrial dysfunction and insufficient autophagy may contribute to multiple aging-associated pathologies...
  13. doi Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4
    Matilde Todaro
    Department of Surgical and Oncological Sciences, Cellular and Molecular Pathophysiology Laboratory, University of Palermo, 90127 Palermo, Italy
    Cell Stem Cell 1:389-402. 2007
    ..Our data suggest that colon tumor growth is dictated by stem-like cells that are treatment resistant due to the autocrine production of IL-4...
  14. pmc Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond
    Hristelina Ilieva
    Ludwig Institute for Cancer Research and Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Cell Biol 187:761-72. 2009
  15. doi Activated endothelial cells induce neutrophil extracellular traps and are susceptible to NETosis-mediated cell death
    Anurag Kumar Gupta
    University Women s Hospital, Department of Biomedicine, Basel University Hospital, Basel, Switzerland
    FEBS Lett 584:3193-7. 2010
    ..These findings offer new insight into mechanisms whereby NETs trigger damage to the endothelium in sepsis, small vessel vasculitis and possibly the villous trophoblast in preeclampsia...
  16. pmc MicroRNAs in cell proliferation, cell death, and tumorigenesis
    H W Hwang
    Program in Human Genetics and Molecular Biology, The Institute of Genetic Medicine, Johns Hopkins University School of Medicine, 733 N Broadway, BRB 460C, Baltimore, MD 21205, USA
    Br J Cancer 94:776-80. 2006
    ..It is now apparent that abnormal miRNA expression is a common feature of human malignancies. In this review, we will discuss how miRNAs influence tumorigenesis by acting as oncogenes and tumour suppressors...
  17. pmc Phagosomal rupture by Mycobacterium tuberculosis results in toxicity and host cell death
    Roxane Simeone
    Institut Pasteur, Unit for Integrated Mycobacterial Pathogenomics, Paris, France
    PLoS Pathog 8:e1002507. 2012
    ..tuberculosis as well as for M. marinum we observed that phagolysosomal rupture was followed by necrotic cell death of the infected macrophages, whereas ESX-1 deletion- or truncation-mutants that remained enclosed within ..
  18. ncbi The role of autophagy in cancer development and response to therapy
    Yasuko Kondo
    Department of Neurosurgery, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Nat Rev Cancer 5:726-34. 2005
    ..What is the present state of our knowledge about the role of autophagy in cancer development, and in response to therapy? And how can the autophagic process be manipulated to improve anticancer therapeutics?..
  19. ncbi Autophagy: dual roles in life and death?
    Eric H Baehrecke
    Eric H Baehrecke is at the Center for Biosystems Research, University of Maryland Biotechnology Institute, College Park, Maryland 20742, USA
    Nat Rev Mol Cell Biol 6:505-10. 2005
    ..Recent studies indicate that autophagy also functions in cell death, but the precise role of this catabolic process in dying cells is not clear...
  20. ncbi Control of microglial neurotoxicity by the fractalkine receptor
    Astrid E Cardona
    Neuroinflammation Research Center and Department of Neurosciences, Lerner Research Institute, Cleveland, Ohio 44195, USA
    Nat Neurosci 9:917-24. 2006
    ..Augmenting CX3CR1 signaling may protect against microglial neurotoxicity, whereas CNS penetration by pharmaceutical CX3CR1 antagonists could increase neuronal vulnerability...
  21. ncbi Poly(ADP-ribose): novel functions for an old molecule
    Valerie Schreiber
    Département Intégrité du Génome de l UMR 7175, Centre National de la Recherche Scientifique, Ecole Superieure de Biotechnologie de Strasbourg, Boulevard S Brant, BP 10413, F 67412 Illkirch cedex, France
    Nat Rev Mol Cell Biol 7:517-28. 2006
    ..These functions include transcriptional regulation, telomere cohesion and mitotic spindle formation during cell division, intracellular trafficking and energy metabolism...
  22. pmc Neutrophil extracellular traps directly induce epithelial and endothelial cell death: a predominant role of histones
    Mona Saffarzadeh
    School of Medicine, Institute of Biochemistry, Justus Liebig University, Giessen, Germany
    PLoS ONE 7:e32366. 2012
    ..These data reveal the important role of protein components in NET, particularly histones, which may lead to host cell cytotoxicity and may be involved in lung tissue destruction...
  23. pmc Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis
    Koji Yamanaka
    Ludwig Institute for Cancer Research and Department of Medicine and Neuroscience, University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093 0670, USA
    Nat Neurosci 11:251-3. 2008
    ..These findings demonstrate that mutant astrocytes are viable targets for therapies for slowing the progression of non-cell autonomous killing of motor neurons in ALS...
  24. doi Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis
    L Ouyang
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China
    Cell Prolif 45:487-98. 2012
    Programmed cell death (PCD), referring to apoptosis, autophagy and programmed necrosis, is proposed to be death of a cell in any pathological format, when mediated by an intracellular program...
  25. ncbi Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities
    Miriam Cnop
    Laboratory of Experimental Medicine, Faculty of Medicine, Erasmus Hospital, Universite Libre de Bruxelles ULB, Route de Lennik 808, CP 618, 1070 Brussels, Belgium
    Diabetes 54:S97-107. 2005
    ..Apoptosis is probably the main form of beta-cell death in both forms of the disease...
  26. ncbi Mitochondria, oxidative stress and cell death
    Martin Ott
    Institute of Environmental Medicine, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Apoptosis 12:913-22. 2007
    In addition to the well-established role of the mitochondria in energy metabolism, regulation of cell death has recently emerged as a second major function of these organelles...
  27. ncbi Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate
    Dunyaporn Trachootham
    Department of Molecular Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Cell 10:241-52. 2006
    ..Excessive ROS causes oxidative mitochondrial damage, inactivation of redox-sensitive molecules, and massive cell death. In vivo, PEITC exhibits therapeutic activity and prolongs animal survival.
  28. doi RIP kinases at the crossroads of cell death and survival
    Wim Declercq
    Molecular Signaling and Cell Death Unit, Department for Molecular Biomedical Research, VIB, 9052 Ghent, Belgium
    Cell 138:229-32. 2009
    ..kinases of the receptor interacting protein (RIP) family collaborate with death receptor proteins to regulate cell death. Recent studies (Cho et al., 2009; He et al., 2009; Zhang et al...
  29. doi DNA damage-induced cell death: from specific DNA lesions to the DNA damage response and apoptosis
    Wynand P Roos
    Department of Toxicology, University of Mainz, Obere Zahlbacher Str 67, D 55131 Mainz, Germany
    Cancer Lett 332:237-48. 2013
    DNA damaging agents are potent inducers of cell death triggered by apoptosis...
  30. pmc Berberine induces caspase-independent cell death in colon tumor cells through activation of apoptosis-inducing factor
    Lihong Wang
    Department of Pediatrics, Vanderbilt University Medical Center and the Monroe Carell Jr Children s Hospital at Vanderbilt, Nashville, Tennessee, United States of America
    PLoS ONE 7:e36418. 2012
    ..Berberine decreased colon tumor colony formation in agar, and induced cell death and LDH release in a time- and concentration-dependent manner in IMCE cells...
  31. doi ERK and cell death: mechanisms of ERK-induced cell death--apoptosis, autophagy and senescence
    Sebastien Cagnol
    Department of Anatomy and Cellular Biology, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, Quebec, Canada
    FEBS J 277:2-21. 2010
    ..These unusual effects require sustained ERK activity in specific subcellular compartments and could depend on the presence of reactive oxygen species. We will summarize the mechanisms involved in Ras/Raf/ERK antiproliferative functions...
  32. ncbi Mitochondrial membrane permeabilization in cell death
    Guido Kroemer
    Institut Gustave Roussy, Institut National de la Santé et de la Recherche Médicale Unit Apoptosis, Cancer and Immunity, Universite de Paris Sud XI, Villejuif, France
    Physiol Rev 87:99-163. 2007
    Irrespective of the morphological features of end-stage cell death (that may be apoptotic, necrotic, autophagic, or mitotic), mitochondrial membrane permeabilization (MMP) is frequently the decisive event that delimits the frontier ..
  33. pmc How ERK1/2 activation controls cell proliferation and cell death: Is subcellular localization the answer?
    Yohannes Mebratu
    Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive SE, Albuquerque, NM 87108, USA
    Cell Cycle 8:1168-75. 2009
    ..cascade controlling cell proliferation has been well studied but the mechanisms involved in ERK1/2-mediated cell death are largely unknown...
  34. doi Death through a tragedy: mitotic catastrophe
    H Vakifahmetoglu
    Division of Toxicology, Institute of Environmental Medicine, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Cell Death Differ 15:1153-62. 2008
    Mitotic catastrophe (MC) has long been considered as a mode of cell death that results from premature or inappropriate entry of cells into mitosis and can be caused by chemical or physical stresses...
  35. ncbi Autophagy and signaling: their role in cell survival and cell death
    P Codogno
    1INSERM U504, Glycobiologie et Signalisation Cellulaire, Institut Andre Lwoff, 16 Avenue Paul Vaillant Couturier, 94807 Villejuif Cedex, France
    Cell Death Differ 12:1509-18. 2005
    ..However, a considerable body of literature reports that macroautophagy is also a cell death mechanism that can occur either in the absence of detectable signs of apoptosis (via autophagic cell death) or ..
  36. pmc Arabidopsis gp91phox homologues AtrbohD and AtrbohF are required for accumulation of reactive oxygen intermediates in the plant defense response
    Miguel Angel Torres
    Department of Biology and Curriculum in Genetics and Molecular Biology, CB 3280, 108 Coker Hall, University of North Carolina, Chapel Hill, NC 27599 3280, USA
    Proc Natl Acad Sci U S A 99:517-22. 2002
    ..tomato DC3000(avrRpm1) and the oomycete parasite Peronospora parasitica. We also observed reduced cell death, visualized by trypan blue stain and reduced electrolyte leakage, in the Atrboh mutants after DC3000(avrRpm1) ..
  37. pmc Differential requirement for Caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processing
    Petr Broz
    Department of Microbiology and Immunology, Stanford School of Medicine, Stanford University, Stanford, CA 94305, USA
    Cell Host Microbe 8:471-83. 2010
    ..and for release of the cytokines interleukin-1β and interleukin-18, and it can also cause rapid macrophage cell death. We show that macrophage cell death and cytokine maturation in response to infection with diverse bacterial ..
  38. pmc Tp53-induced glycolysis and apoptosis regulator (TIGAR) protects glioma cells from starvation-induced cell death by up-regulating respiration and improving cellular redox homeostasis
    Christina Wanka
    Dr Senckenberg Institute of Neurooncology, Goethe University Frankfurt, Frankfurt, Germany
    J Biol Chem 287:33436-46. 2012
    ..effects of the p53-dependent effector Tp53-induced glycolysis and apoptosis regulator (TIGAR) on hypoxia-induced cell death. We demonstrate that TIGAR is overexpressed in glioblastomas and that ectopic expression of TIGAR reduces cell ..
  39. doi An emerging player in the adaptive immune response: microRNA-146a is a modulator of IL-2 expression and activation-induced cell death in T lymphocytes
    Graziella Curtale
    Dipartimento di Biotecnologie Cellulari ed Ematologia, Sezione di Genetica Molecolare, Universita di Roma, Rome, Italy
    Blood 115:265-73. 2010
    ..In particular, we provide experimental evidence that miR-146a modulates activation-induced cell death (AICD), acting as an antiapoptotic factor, and that Fas-associated death domain (FADD) is a target of miR-146a...
  40. pmc Calpain and PARP activation during photoreceptor cell death in P23H and S334ter rhodopsin mutant rats
    Jasvir Kaur
    Institute for Ophthalmic Research, Centre for Ophthalmology, University of Tubingen, Tubingen, Germany
    PLoS ONE 6:e22181. 2011
    ..An important question regarding RP pathology is whether different genetic defects trigger the same or different cell death mechanisms...
  41. pmc Salicylic acid-independent ENHANCED DISEASE SUSCEPTIBILITY1 signaling in Arabidopsis immunity and cell death is regulated by the monooxygenase FMO1 and the Nudix hydrolase NUDT7
    Michael Bartsch
    Department of Plant Microbe Interactions, Max Planck Institute for Plant Breeding Research, D 50829 Cologne, Germany
    Plant Cell 18:1038-51. 2006
    Arabidopsis thaliana ENHANCED DISEASE SUSCEPTIBILITY1 (EDS1) controls defense activation and programmed cell death conditioned by intracellular Toll-related immune receptors that recognize specific pathogen effectors...
  42. ncbi ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation
    Y Kouroku
    Division of Development, National Institute of Neuroscience, 4 1 1 Ogawahigashi machi, Kodaira, Tokyo 187 8502, Japan
    Cell Death Differ 14:230-9. 2007
    Expanded polyglutamine 72 repeat (polyQ72) aggregates induce endoplasmic reticulum (ER) stress-mediated cell death with caspase-12 activation and vesicular formation (autophagy)...
  43. doi Manipulation of host cell death pathways during microbial infections
    Mohamed Lamkanfi
    Department of Biochemistry, Ghent University, B 9000 Ghent, Belgium
    Cell Host Microbe 8:44-54. 2010
    Viral and microbial infections often elicit programmed cell death as part of the host defense system or as a component of the survival strategy of the pathogen...
  44. ncbi Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)
    J Zha
    Department of Medicine, Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cell 87:619-28. 1996
    ..distant member, BAD, heterodimerizes with BCL-X(L) or BCL-2, neutralizing their protective effect and promoting cell death. In the presence of survival factor IL-3, cells phosphorylated BAD on two serine residues embedded in 14-3-3 ..
  45. ncbi Mitochondrial permeability transition pore opening during myocardial reperfusion--a target for cardioprotection
    Andrew P Halestrap
    Department of Biochemistry and The Bristol Heart Institute, University of Bristol, Bristol BS8 1TD, UK
    Cardiovasc Res 61:372-85. 2004
    ..Unrestrained, this will lead to the loss of ionic homeostasis and ultimately necrotic cell death. The functional recovery of the Langendorff-perfused heart from ischaemia inversely correlates with the extent ..
  46. pmc Signaling cell death from the endoplasmic reticulum stress response
    Gordon C Shore
    Department of Biochemistry and Goodman Cancer Center, McGill University, Montreal, Quebec, H3G 1Y6, Canada
    Curr Opin Cell Biol 23:143-9. 2011
    ..Researchers have begun to elucidate the molecular switches that determine when ER stress is too great to repair and the signals that are then sent from the UPR to execute the cell...
  47. pmc Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes
    L Galluzzi
    INSERM, U848, Villejuif, France
    Cell Death Differ 16:1093-107. 2009
    b>Cell death is essential for a plethora of physiological processes, and its deregulation characterizes numerous human diseases...
  48. pmc Programmed cell death in the plant immune system
    N S Coll
    Department of Biology, University of North Carolina, Chapel Hill, NC 27599, USA
    Cell Death Differ 18:1247-56. 2011
    b>Cell death has a central role in innate immune responses in both plants and animals...
  49. ncbi Cell death by necrosis: towards a molecular definition
    Pierre Golstein
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Case 906, 13288 Marseille Cedex 9, France
    Trends Biochem Sci 32:37-43. 2007
    Necrosis has been defined as a type of cell death that lacks the features of apoptosis and autophagy, and is usually considered to be uncontrolled...
  50. pmc Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease
    Vanessa Brochard
    INSERM, UMR S679, Experimental Neurology and Therapeutics, Hopital de la Salpetriere, Paris, France
    J Clin Invest 119:182-92. 2009
    ..Mounting evidence suggests that dopaminergic cell death is influenced by the innate immune system...
  51. ncbi The toll-like receptor TLR4 is necessary for lipopolysaccharide-induced oligodendrocyte injury in the CNS
    Seija Lehnardt
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Neurosci 22:2478-86. 2002
    ..Our data provide a general mechanistic link between (1) lipopolysaccharide and similar microbial molecular motifs and (2) injury to oligodendrocytes and myelin as occurs in periventricular leukomalacia and multiple sclerosis...
  52. pmc Caspase functions in cell death and disease
    David R McIlwain
    The Campbell Family Institute for Breast Cancer Research and Ontario Cancer Institute, University Health Network, Toronto, Ontario M5G 2C1, Canada
    Cold Spring Harb Perspect Biol 5:a008656. 2013
    ..a family of endoproteases that provide critical links in cell regulatory networks controlling inflammation and cell death. The activation of these enzymes is tightly controlled by their production as inactive zymogens that gain ..
  53. pmc Autophagic cell death: the story of a misnomer
    Guido Kroemer
    Institut Gustave Roussy, F 94805 Villejuif, France
    Nat Rev Mol Cell Biol 9:1004-10. 2008
    ..cells often display a large-scale accumulation of autophagosomes and hence adopt a morphology called autophagic cell death. In many cases, it is agreed that this autophagic cell death is cell death with autophagy rather than cell death ..
  54. ncbi A common mechanism of cellular death induced by bactericidal antibiotics
    Michael A Kohanski
    Center for BioDynamics and Center for Advanced Biotechnology, Boston University, Boston, MA 02215, USA
    Cell 130:797-810. 2007
    ..highly deleterious hydroxyl radicals in Gram-negative and Gram-positive bacteria, which ultimately contribute to cell death. We also show, in contrast, that bacteriostatic drugs do not produce hydroxyl radicals...
  55. ncbi CoCl2, a chemical inducer of hypoxia-inducible factor-1, and hypoxia reduce apoptotic cell death in hepatoma cell line HepG2
    Jean Pascal Piret
    Laboratoire de Biologie et Biochimie Cellulaire, FUNDP, 5000 Namur, Belgium
    Ann N Y Acad Sci 973:443-7. 2002
    ..However, it has also been reported that hypoxia could protect cells against apoptotic cell death induced by various agents such as serum deprivation and incubation in the presence of chemotherapy agents...
  56. doi Immunogenic cell death in cancer therapy
    Guido Kroemer
    Annu Rev Immunol 31:51-72. 2013
    Depending on the initiating stimulus, cancer cell death can be immunogenic or nonimmunogenic...
  57. doi Expansion and evolution of cell death programmes
    Alexei Degterev
    Tufts University, School of Medicine, Department of Biochemistry, 136 Harrison Ave, Boston, Massachusetts 02111, USA
    Nat Rev Mol Cell Biol 9:378-90. 2008
    b>Cell death has historically been subdivided into regulated and unregulated mechanisms. Apoptosis, a form of regulated cell death, reflects a cell's decision to die in response to cues and is executed by intrinsic cellular machinery...
  58. pmc Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells
    Maria Salazar
    Department of Biochemistry and Molecular Biology, Complutense University, Madrid, Spain
    J Clin Invest 119:1359-72. 2009
    Autophagy can promote cell survival or cell death, but the molecular basis underlying its dual role in cancer remains obscure...
  59. ncbi Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule
    N Holler
    Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Nat Immunol 1:489-95. 2000
    b>Cell death is achieved by two fundamentally different mechanisms: apoptosis and necrosis. Apoptosis is dependent on caspase activation, whereas the caspase-independent necrotic signaling pathway remains largely uncharacterized...
  60. doi Glutamate receptors, neurotoxicity and neurodegeneration
    Anthony Lau
    Division of Applied and Interventional Research, Toronto Western Research Institute, 399 Bathurst Street, Toronto, ON, Canada, M5T 2S8
    Pflugers Arch 460:525-42. 2010
    ..focusing on the structure and physiology of glutamate receptors; molecular mechanisms underlying excitotoxic cell death pathways and their interactions with each other; the evidence for glutamate excitotoxicity in acute neurologic ..
  61. pmc A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death
    Abhishek D Garg
    Cell Death Research and Therapy Unit, Department of Cellular and Molecular Medicine KU Leuven, KU Leuven, Leuven, Belgium
    EMBO J 31:1062-79. 2012
    ..These results unravel a novel PERK-dependent subroutine for the early and simultaneous emission of two critical DAMPs following ROS-mediated ER stress...
  62. doi Anti-NeuGcGM3 antibodies, actively elicited by idiotypic vaccination in nonsmall cell lung cancer patients, induce tumor cell death by an oncosis-like mechanism
    Ana Maria Hernandez
    Department of Antibody Engineering, Center of Molecular Immunology, Havana 11600, Cuba
    J Immunol 186:3735-44. 2011
    ..These results contribute to reinforcing the therapeutic potential of anti-idiotypic vaccines and the importance of NeuGcGM3 ganglioside as antitumor target...
  63. doi Coiled-coil domain-dependent homodimerization of intracellular barley immune receptors defines a minimal functional module for triggering cell death
    Takaki Maekawa
    Department of Plant Microbe Interactions, Max Planck Institut für Pflanzenzüchtungsforschung, Carl von Linne Weg 10, 50829 Cologne, Germany
    Cell Host Microbe 9:187-99. 2011
    ..MLA CC mutants that fail to self-interact impair in planta cell death activity triggered by the CC domain alone and by an autoactive full-length MLA receptor that mimics its ATP-..
  64. ncbi Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes
    Alexandra E Butler
    Division of Endocrinology and Diabetes, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Diabetes 52:102-10. 2003
  65. doi Mitochondria and cell death: outer membrane permeabilization and beyond
    Stephen W G Tait
    Department of Immunology, St Jude Childrens Research Hospital, Memphis, Tennessee 38105, USA
    Nat Rev Mol Cell Biol 11:621-32. 2010
    ..membrane permeabilization (MOMP) is often required for activation of the caspase proteases that cause apoptotic cell death. Various intermembrane space (IMS) proteins, such as cytochrome c, promote caspase activation following their ..
  66. ncbi ALS: a disease of motor neurons and their nonneuronal neighbors
    Severine Boillee
    Ludwig Institute for Cancer Research and Departments of Medicine and Neuroscience, University of California, San Diego, La Jolla, California 92093, USA
    Neuron 52:39-59. 2006
    ..Damage within motor neurons is enhanced by damage incurred by nonneuronal neighboring cells, via an inflammatory response that accelerates disease progression. These findings validate therapeutic approaches aimed at nonneuronal cells...
  67. doi Selective cell death in neurodegeneration: why are some neurons spared in vulnerable regions?
    K L Double
    Neuroscience Research Australia and the University of New South Wales, NSW 2031, Australia
    Prog Neurobiol 92:316-29. 2010
    Neurodegenerative diseases exhibit varying and characteristic patterns of regional brain cell death, yet in each disorder there are distinct variations in the relative vulnerability of neurons within targeted brain regions...
  68. pmc Catabolite control protein A controls hydrogen peroxide production and cell death in Streptococcus sanguinis
    Lanyan Zheng
    Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    J Bacteriol 193:516-26. 2011
    ..In addition to its well-known role in bacterial antagonism during interspecies competition, H₂O₂ causes cell death in about 10% of the S. sanguinis population...
  69. pmc Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1
    Petr Broz
    Department of Microbiology and Immunology, Stanford School of Medicine, Stanford University, California 94305, USA
    Nature 490:288-91. 2012
    ..and release of the pro-inflammatory cytokines interleukin (IL)-1β and IL-18, as well as lytic inflammatory cell death known as pyroptosis...
  70. doi HIV-1 causes CD4 cell death through DNA-dependent protein kinase during viral integration
    Arik Cooper
    Virology Laboratory, Vaccine Research Center, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 3005, USA
    Nature 498:376-9. 2013
    ..viral DNA and are rapidly eliminated at the peak of viraemia, yet the mechanism by which HIV-1 induces helper T-cell death has not been defined. Here we show that virus-induced cell killing is triggered by viral integration...
  71. ncbi ROS, mitochondria and the regulation of autophagy
    Ruth Scherz-Shouval
    Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot, 76100 Israel
    Trends Cell Biol 17:422-7. 2007
    ..origin as signaling molecules in autophagy, leading, under different circumstances, to either survival or cell death. We then discuss the relationship between mitochondria and autophagosomes and propose that mitochondria have an ..
  72. pmc ER stress-induced cell death mechanisms
    Renata Sano
    Sanford Burnham Medical Research Institute, La Jolla, CA, 92037, USA
    Biochim Biophys Acta 1833:3460-70. 2013
    ..In cases where ER stress cannot be reversed, cellular functions deteriorate, often leading to cell death. Accumulating evidence implicates ER stress-induced cellular dysfunction and cell death as major contributors to ..
  73. doi The role of iron and reactive oxygen species in cell death
    Scott J Dixon
    1 Department of Biological Sciences, Columbia University, New York, New York, USA 2 Department of Biology, Stanford University, Stanford, California, USA
    Nat Chem Biol 10:9-17. 2014
    ..Iron and ROS are increasingly recognized as important initiators and mediators of cell death in a variety of organisms and pathological situations...
  74. pmc Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo
    Tim Lämmermann
    Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0421, USA
    Nature 498:371-5. 2013
    ..intercellular signal relay among neutrophils mediated by the lipid leukotriene B4, which acutely amplifies local cell death signals to enhance the radius of highly directed interstitial neutrophil recruitment...
  75. pmc Caspase-1-induced pyroptotic cell death
    Edward A Miao
    Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Immunol Rev 243:206-14. 2011
    Programmed cell death is a necessary part of development and tissue homeostasis enabling the removal of unwanted cells...
  76. ncbi Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
    Taichi Hara
    Department of Bioregulation and Metabolism, Tokyo Metropolitan Institute of Medical Science, Tokyo 113 8613, Japan
    Nature 441:885-9. 2006
  77. pmc Snail blocks the cell cycle and confers resistance to cell death
    Sonia Vega
    Instituto Cajal, Consejo Superior de Investigaciones Cieutificas, 28002 Madrid, Spain
    Genes Dev 18:1131-43. 2004
    ..addition to inducing dramatic phenotypic alterations, Snail attenuates the cell cycle and confers resistance to cell death induced by the withdrawal of survival factors and by pro-apoptotic signals...
  78. ncbi Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death
    Christopher P Baines
    Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Nature 434:658-62. 2005
    Mitochondria play a critical role in mediating both apoptotic and necrotic cell death. The mitochondrial permeability transition (mPT) leads to mitochondrial swelling, outer membrane rupture and the release of apoptotic mediators...
  79. doi Decoding cell death signals in liver inflammation
    Catherine Brenner
    INSERM, UMRS 769, LabEx LERMIT, F 92290 Chatenay Malabry, France
    J Hepatol 59:583-94. 2013
    ..stimulate inflammatory responses, hence establishing a highly hepatotoxic feedforward cycle of inflammation and cell death. In this review, we discuss the cellular and molecular mechanisms that account for the most deleterious effect ..
  80. pmc AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
    Teresa Fernandes-Alnemri
    Department of Biochemistry and Molecular Biology, Center for Apoptosis Research, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Nature 458:509-13. 2009
    ..The interaction of AIM2 with ASC also leads to the formation of the ASC pyroptosome, which induces pyroptotic cell death in cells containing caspase-1...
  81. ncbi Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection
    Joseph J Mattapallil
    Immunotechnology Section, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland 20892, USA
    Nature 434:1093-7. 2005
    ..Our findings point to the importance of reducing the cell-associated viral load during acute infection through therapeutic or vaccination strategies...
  82. pmc Immunogenic and tolerogenic cell death
    Douglas R Green
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA e mails
    Nat Rev Immunol 9:353-63. 2009
    ..Mechanisms must exist to discriminate between different forms of cell death to correctly eliminate pathogens and promote healing while avoiding responses to self, which can result in ..
  83. doi Cell death in the pathogenesis of heart disease: mechanisms and significance
    Russell S Whelan
    Wilf Family Cardiovascular Research Institute and the Departments of Medicine and Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Annu Rev Physiol 72:19-44. 2010
    b>Cell death was once viewed as unregulated. It is now clear that at least a portion of cell death is a regulated cell suicide process. This type of death can exhibit multiple morphologies...
  84. ncbi 14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation
    S R Datta
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell 6:41-51. 2000
    ..These findings define a mechanism by which survival signals inactivate a proapoptotic Bcl-2 family member, and suggest a role for 14-3-3 proteins as cofactors that regulate sequential protein phosphorylation events...
  85. pmc Uric acid promotes an acute inflammatory response to sterile cell death in mice
    Hajime Kono
    Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Clin Invest 120:1939-49. 2010
    ..acid either intracellularly and/or extracellularly, we found that uric acid depletion substantially reduces the cell death-induced inflammatory response...
  86. doi Immunogenic tumor cell death for optimal anticancer therapy: the calreticulin exposure pathway
    Laurence Zitvogel
    INSERM, U1015, and CICBT507, Villejuif, France
    Clin Cancer Res 16:3100-4. 2010
    ..We speculate that human cancers that are incapable of activating the CRT exposure pathway are refractory to the immune-mediated component of anticancer therapies...
  87. doi Lysosomes and lysosomal cathepsins in cell death
    Urska Repnik
    Department of Biochemistry and Molecular and Structural Biology, J Stefan Institute, Jamova, Ljubljana, Slovenia
    Biochim Biophys Acta 1824:22-33. 2012
    ..This further suggests that lysosomes and lysosomal cathepsins have a dual role in cell death. This article is part of a Special Issue entitled: Proteolysis 50 years after the discovery of lysosome.
  88. doi Mitochondrial dynamics in yeast cell death and aging
    Ralf J Braun
    Institut fur Zellbiologie, Universitat Bayreuth, 95440 Bayreuth, Germany
    Biochem Soc Trans 39:1520-6. 2011
    Mitochondria play crucial roles in programmed cell death and aging...
  89. ncbi Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8
    Li Yu
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Science 304:1500-2. 2004
    Caspases play a central role in apoptosis, a well-studied pathway of programmed cell death. Other programs of death potentially involving necrosis and autophagy may exist, but their relation to apoptosis and mechanisms of regulation ..
  90. doi Cancer cells display profound intra- and interline variation following prolonged exposure to antimitotic drugs
    Karen E Gascoigne
    Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Cancer Cell 14:111-22. 2008
    ..We present data supporting a model wherein cell fate is dictated by two competing networks, one involving caspase activation, the other protecting cyclin B1 from degradation...
  91. doi Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity
    Hartmut Jaeschke
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, 66160, USA
    Drug Metab Rev 44:88-106. 2012
    ..Together, these events trigger necrotic cell death. Alternatively, the release of cytochrome c and other proapoptotic factors from mitochondria can promote caspase ..
  92. pmc Peculiarities of cell death mechanisms in neutrophils
    B Geering
    Institute of Pharmacology, University of Bern, Friedbuehlstrasse 49, Bern, Switzerland
    Cell Death Differ 18:1457-69. 2011
    ..with other cell types; however, a few important molecular features make these cells unique executors of cell death mechanisms...
  93. doi Cell death in the host response to infection
    K Labbe
    Department of Microbiology and Immunology, McGill University, Montreal, Canada H3A 2B4
    Cell Death Differ 15:1339-49. 2008
    ..elicit diverse responses in the host that include activation of the innate immune system, inflammation and cell death. Pathogen-triggered cell death is manifested by various morphologies indicative of apoptosis, pyroptosis, ..
  94. pmc The role of autophagy in mammalian development: cell makeover rather than cell death
    Francesco Cecconi
    Dulbecco Telethon Institute at the Department of Biology, University of Rome Tor Vergata, 00133 Rome, Italy
    Dev Cell 15:344-57. 2008
    ..In lower eukaryotes, autophagy functions as a cell death mechanism or as a stress response during development...
  95. pmc Cell death mechanisms and modulation in traumatic brain injury
    Bogdan A Stoica
    Shock, Trauma and Anesthesiology Research Center, National Study Center for Trauma and EMS, University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA
    Neurotherapeutics 7:3-12. 2010
    b>Cell death after traumatic brain injury (TBI) is a major cause of neurological deficits and mortality. Understanding the mechanisms of delayed post-traumatic cell loss may lead to new therapies that improve outcome...
  96. ncbi Glutathione S-transferase p elicits protection against H2O2-induced cell death via coordinated regulation of stress kinases
    Z Yin
    Ruttenberg Cancer Center, Mount Sinai School of Medicine, New York, New York 10029, USA
    Cancer Res 60:4053-7. 2000
    ..underlying glutathione S-transferase p (GSTp)-mediated cellular protection against oxidative stress-induced cell death, the effect of GSTp on stress signaling pathways was investigated before and after H2O2 treatment...
  97. pmc Endoplasmic reticulum stress: cell life and death decisions
    Chunyan Xu
    The Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Clin Invest 115:2656-64. 2005
    ..the unfolded protein response, which is aimed initially at compensating for damage but can eventually trigger cell death if ER dysfunction is severe or prolonged...
  98. ncbi Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases
    Hideaki Kamata
    Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Cell 120:649-61. 2005
    TNFalpha is a pleiotropic cytokine that induces either cell proliferation or cell death. Inhibition of NF-kappaB activation increases susceptibility to TNFalpha-induced death, concurrent with sustained JNK activation, an important ..
  99. doi New frontiers in promoting tumour cell death: targeting apoptosis, necroptosis and autophagy
    J S Long
    Tumour Cell Death Laboratory, Beatson Institute for Cancer Research, Glasgow, UK
    Oncogene 31:5045-60. 2012
    ..Many oncogenic events while promoting tumour development also increase the sensitivity of cells to cell death stimuli including chemotherapeutic drugs...
  100. ncbi Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf
    Sanjeev Mariathasan
    Molecular Oncology Department, Genentech, Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nature 430:213-8. 2004
    ..Notably, cell death triggered by stimuli that engage caspase-1 was ablated in macrophages lacking either ASC or Ipaf, suggesting a ..
  101. doi SIRT3, a pivotal actor in mitochondrial functions: metabolism, cell death and aging
    Albert Giralt
    Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, University of Barcelona, Spain
    Biochem J 444:1-10. 2012

Research Grants76

  1. Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
    Ryan Bailey; Fiscal Year: 2009
    ..This technology promises to broadly impact the landscape of the biomedical sciences, both meeting the clinical diagnostic challenges of today and pioneering the paradigm-shifting discoveries of tomorrow. ..
  2. NIH Director's Pioneer Award
    Junying Yuan; Fiscal Year: 2009
    ..No Abstract provided ..
  3. Optimization of DNA Repair by Abh8
    Lauren Endres; Fiscal Year: 2013
    ..If left unrepaired, these DNA lesions can result in cell death or mutations...
  4. Anti-tumor properties of curcumin in oral cancers: role of thioredoxin reductase
    STEPHEN WILLIAM TUTTLE; Fiscal Year: 2010
    ..administered in the diet alone or in combination with ionizing radiation on orthotopic tumor growth and tumor cell death will be measured...
  5. Prevention of Acute Lung Injury by IL-6 activated STAT3
    Ana Moran; Fiscal Year: 2010
    ..Microarray analysis in rat lungs showed that T/HS increased the expression of genes in the ontologic category of cell death and altered 70% of known apoptosis-related genes...
  6. Novel Mitochondrial Mechanisms of Ethanol-Induced Cardiac Injury in Aged Females
    DONNA HOPE KORZICK; Fiscal Year: 2010
    ..Of particular interest are adaptive changes in proteins associated with metabolism, oxidative stress, and cell death. Specific aims are as follows: 1) chronic ethanol ingestion will exacerbate age-related increases in I/R injury ..
  7. Soluble Epoxide Hydrolase as a Target for Ischemic Cardioprotection
    Donna M Van Winkle; Fiscal Year: 2012
    ..with triphenyltetrazolium staining, cardiac function with a left ventricular conductance catheter, and in vitro cell death by propidium iodide uptake. Measurement of EETs will be performed by liquid chromatography/mass spectrometry...
  8. Regulation of ER stress-induced cell death
    Randal J Kaufman; Fiscal Year: 2013
    ..Aim 3, How do eIF2a phosphorylation and CHOP expression prevent cell death? We will evaluate the role of ATF4 in cell death and screen for genes that regulate ER stress induced cell death...
  9. Epigenetic mechanisms relevant to the pathogenesis of ALS
    Neil W Kowall; Fiscal Year: 2013
    ..The specific aims of the study are: 1) To determine the relationship between LSD1 induction in motor neurons and cell death mediated by oxidative stress in vitro;2) To determine the role of LSD1 in the survival of motor neurons ..
  10. Sphingolipid Metabolism in Drosophila Development
    Julie D Saba; Fiscal Year: 2013
    ..underlies many human disease states including neurodegenerative diseases, cardiomyopathies, cancer, programmed cell death, and bacterial and viral infections. Thus, our research plan has potentially broad translational significance.
  11. Translational Machinery in Stress Signaling and Tumor Suppression
    THOMAS J contact BEGLEY; Fiscal Year: 2010
    ..such as endoplasmic reticulum (ER) stress, can arrest cell growth and promote the repair of damage or promote cell death. Similarly, translational regulation has recently been associated with the DNA damage response, and appears to ..
  12. Investigating Mechanism of Intracellular Rotational Transport with Optical T
    Jeffrey N Anker; Fiscal Year: 2012
    ..messengers and the depletion of antioxidants, cause global cytoskeletal damage and dysfunction, DNA damage, and cell death. We will test this hypothesis by studying the effect of nanoparticle composition on the motion and transport of ..
  13. Collagen X and heparan sulfate proteoglycan in the hematopoietic stem cell niche.
    ELIZABETH G SWEENEY; Fiscal Year: 2012
    ..modification, transcriptional regulation of differentiation, growth hormones, respiration, cell cycle, cell death, spermatogenesis, obesity, stress, immunology, eye development, and dinosaur paleobiology...
    Terence S Dermody; Fiscal Year: 2013
    ..Targets of reovirus infection in vivo will be monitored for apoptotic cell death following inoculation with wild-type and als-mutant viruses to define the function of a1s- induced apoptosis in ..
  15. Combination drug treatment to inhibit multiple cell death pathways after TBI
    ALAN IRA FADEN; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): This application entitled "Attenuation of Diverse Cell Death Pathways after Traumatic Brain Injury by Multi- drug Combination Therapy" addresses Broad Challenge Area (15): Translational Science and ..
  16. Enzymatic Regulation of S-Glutathionylation : Role in Apoptosis and Disease
    John J Mieyal; Fiscal Year: 2012
    ..key factor in PD, is likely to perturb natural redox signaling and promote inflammatory responses and apoptotic cell death. Recent studies in the laboratory of the Principal Investigator have revealed that treatment of human ..
  17. TLR4 Inhibition to Reduce Cerebral Ischemia Reperfusion Injury
    LORI ANN HOLLE; Fiscal Year: 2011
    ..occluded due to embolic stroke, inflammation and edema due to IRI is responsible for a large amount of neuronal cell death in the penumbrum, a large zone around the infarcted area...
  18. Regulation of myocardial growth and death by GSK-3
    Junichi Sadoshima; Fiscal Year: 2013
    ..ischemia inhibits mTOR through a TSC2-dependent mechanism, stimulates autophagy, and protects the heart from cell death. On the other hand, phosphorylation/inactivation of GSK-3b during reperfusion is beneficial through activation ..
  19. Mechanisms of Sex Determination in Zebrafish
    ..Preliminary experiments show excess cell death in homozygous mutant juvenile gonads and suggest the hypothesis that 1) environmental and genetic factors affect ..
  20. Sirtuin/FOXO Signaling in the Regulation of Bone Mass
    Stavroula Kousteni; Fiscal Year: 2012
    ..The mammalian homolog SIRT1, deacetylates FOXO1, thus shifting FOXO-dependent responses away from cell death and towards cell survival...
  21. Gene Therapy with Cardiotropic Vectors for the Treatment of Heart Failure
    Roger J Hajjar; Fiscal Year: 2013
    ..that remain are under continuous stress from hormonal and physical stimuli that can induce apoptosis and cell death or render them dysfunctional...
  22. Mechanism-Based Discovery of Protectants Against Iron-Dependant Oxidative Injury
    JUSTIN M SCHWARTZ; Fiscal Year: 2011
    ..to promote intramitochondrial OH7 formation, the mitochondrial permeability transition (MPT) and ultimately cell death. The overall goal of the project to better characterize this process and to develop novel and potentially ..
  23. Genetic Studies of Optic Atrophy
    Taosheng Huang; Fiscal Year: 2012
    ..phenotype of dOPA1 mutant large clones, further suggesting that ROS play an important role in cone and pigment cell death. Our preliminary results also show that some OPA1 mutations cause loss of vision, hearing, and other organ ..
  24. Therapeutic Effect of a Novel Antioxidant on Degenerative Eye Disorders
    Nuran Ercal; Fiscal Year: 2012
    ..and 2) retinal degeneration in rd10+/+ and Ccl2-/- mice that spontaneously develop progressive photoreceptor cell death either early (rd10+/+) or later (Ccl2-/-)...
  25. Arsenic Trioxide and Acute Myeloid Leukemia
    Yongkui Jing; Fiscal Year: 2012
    ..derivatives of ethyacrynic acid which block enzymes that diminish ROS and markedly enhanceAs2O3 induced leukemic cell death by several mechanisms...
  26. Regulation of K-Ras by a Farnesyl-electrostatic Switch
    MARK REID PHILIPS; Fiscal Year: 2013
    ..Most intriguing, K-Ras translocation to internal membranes was associated with cell death. Bryostatin 1, a potent PKC agonist, showed anti-tumor activity that was dependent on K-Ras serine 181...
  27. Targeting Cell Death to Prevent Ventricular Remodeling and Heart Failure
    Abhinav Diwan; Fiscal Year: 2011
    ..critically examines the role of two cardiac expressed proteins, Bnip3 and Nix, in causing cardiac muscle cell death in these conditions, with the potential for development of clinical therapies to salvage cardiac muscle and ..
  28. Complex I: Role of L Subunit in Proton Translocation
    Steven B Vik; Fiscal Year: 2011
    ..In humans Complex I plays additional roles in the mitochondrion related to oxidative stress, cell signaling, and cell death. For example, blockage of electron transport can increase the production of superoxide by Complex I, leading to ..
  29. Overcoming Temozolomide Resistance using MGMT-targeting Spherical Nucleic Acids
    TIMOTHY L SITA; Fiscal Year: 2013
    ..Prior to running in vivo experiments, we will establish a relationship between MGMT, TMZ, and cell death in our TNS cultures...
  30. Cellular and Animal Models of FUS Mutations in ALS
    Eric J Huang; Fiscal Year: 2013
    ..characterize the mechanisms by which FUS-R521C and FUS-P525L mutant proteins affect synaptic degeneration and cell death in primary neurons...
  31. Regulation of LPS-mediated HMGB1 Release by Poly (ADP-ribose) Polymerase-1
    RAJESH K ANEJA; Fiscal Year: 2013
    ..dinucleotide (NAD+), with consequent depletion of adenosine-5'-triphosphate (ATP), energy failure and cell death. The proposed research plan will define the role of PARP-1 in the modulation of lipopolysaccharide (LPS)-..
    Cornelia M Weyand; Fiscal Year: 2012
    ..Specific Aim 2 is centered on molecular mechanisms mediating na[unreadable]ve CD4 T cell death with special emphasis on BCL-2 family members that function as survival proteins, pro-apoptotic executioners, or ..
  33. Protection of Brain Injury from Cyanide Poisoning by Carnosic Acid
    Stuart A Lipton; Fiscal Year: 2013
    ..to neurons is dysfunctional glutamate transport and ionic pump failure, contributing to excitotoxic neuronal cell death by overstimulation of NMDA-type glutamate receptors (NMDARs)...
  34. Mechanisms of virus-induced injury in the brain and spinal cord
    Kenneth L Tyler; Fiscal Year: 2013
    ..characterized models of virus-induced CNS disease to investigate the mechanisms by which viruses cause neuronal cell death and injury to the brain and spinal cord...
  35. Characterization of new toxins (YmgD and YdfD) from E.coli, targeting cell wall
    Hisako Masuda; Fiscal Year: 2012
    ..This is the first example of TA toxins targeting cell walls to cause cell death. Interestingly, YmgD is produced with a signal peptide and is the first toxin discovered to be secreted into the ..
  36. Mechanism Underlying Nitrite Sensitivity of Mucoid Pseudomonas in COPD
    Daniel J Hassett; Fiscal Year: 2013
    ..trans restored A-NO2- resistance and subsequent experiments established that nitric oxide (NO) plays a role in cell death. Importantly, no adverse effects were observed when A-NO2- was applied to human airway epithelia...
  37. Intracellular Serpin Regulation of Intestinal Cell Necrosis
    GARY ARTHUR SILVERMAN; Fiscal Year: 2012
    ..intracellular proteolysis, loss of membrane integrity, dissolution of sub-cellular architecture and necrotic cell death. The strong association between promiscuous intracellular proteolysis and cell death suggests that peptidase ..
  38. UV-induced and NOS-mediated Zn elevation, translation regulation and apoptosis
    Shiyong Wu; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Cell death induced by ultraviolet light (UV) is a protective response that eliminates damaged cells...
  39. Mitochondrial and Nuclear Mechanisms of Estrogen Receptor-Mediated Cardioprotecti
    DONNA HOPE KORZICK; Fiscal Year: 2012
    ..these signals impact mitochondrial events critical to cell survival to limit necrotic and apoptotic cell death. Here, we propose to test the novel paradigm that maladaptive estrogen receptor (ER) expression in the aged ..
  40. Photodynamic Therapy of Localized Infections
    Michael R Hamblin; Fiscal Year: 2013
    ..species that damage biological molecules such as proteins, lipids and nucleic acids and subsequently cause cell death. In the two funding periods of this grant we have synthesized and characterized several novel highly active ..
  41. Mechanism(s) of Alcoholic Pancreatitis
    Bhupendra S Kaphalia; Fiscal Year: 2011
    ..markers, pancreatic ER stress by measuring the over expression of glucose regulated protein 78 and related cell death pathways, and inflammatory responses by proinflammatory transcription factors and cytokines in the pancreas and/..
  42. Alcohol, Proteasome Dysfunction in Liver Injury
    Craig J McClain; Fiscal Year: 2013
    ..with subsequent proteasome dysfunction leads to LMP and release of lysosomal cathepsins which induce hepatocyte cell death and further sensitize hepatocytes to TNF-mediated hepatotoxicity...
  43. A fully validated assay to identify activators of ERSR in human glioma cells: ide
    Maurizio Grimaldi; Fiscal Year: 2012
    ..Our laboratory has produced a large amount of preliminary data indicating that glioma cells are sensible to cell death induced by triggering endoplasmic reticulum stress response (ERSR)...
  44. Molecular Epidemiology of DNA Repair in Head and Neck Cancer
    Qingyi Wei; Fiscal Year: 2012
    ..cells, which may lead to uncontrolled cell growth, but the cells evolve to have the mechanism of programmed cell death or apoptosis that helps eliminate cells with excessive damage to DNA and thus reduce risk of cancer...
    John J Lemasters; Fiscal Year: 2012
    ..microcirculatory disturbances and inflammation that promote oxidative stress and MPT onset or that MPT-dependent cell death activates inflammation and microcirculatory disturbances...
  46. DNA Damage Checkpoint and Cancer
    Toru Ouchi; Fiscal Year: 2012
    ..Finally, we explore whether down-regulation of BAAT1 facilitates cell death after intentional chemically-induced DNA damage such as chemotherapy...
  47. Mechanistic Studies on Prostate Cancer Prevention by Gugulipid
    Dong Xiao; Fiscal Year: 2013
    ..Our preliminary studies have also shown that the GL-induced cell death in prostate cancer cells was correlated with generation of reactive oxygen species (ROS) and activation of c-Jun ..
  48. Cell stress, development, and stimulant-induced behavior: Regulation by GSK3
    Marjelo A Mines; Fiscal Year: 2012
    ..These responses can allow cells to adapt and survive stress, or can lead to cell death, and inhibitors of GSK3 promote cell adaptation and reduce cell death, but the mechanisms for these regulatory ..
  49. Epigenetic Analysis of iPS Cell Models of Aging and Alzheimer's Disease
    Bruce A Yankner; Fiscal Year: 2010
    ..profiling of AD fibroblasts compared with age-matched controls shows changes in the expression of cell death genes, synaptic genes and genes encoding proteins involved in epigenetic modification of chromatin...
  50. High throughput screen for selective inhibitors of cyclophilin B
    Richard J Bram; Fiscal Year: 2013
    ..on tumor cells, particularly in the case of the D isoform (CypD), which is known to participate in necrotic cell death. In addition, the abundance of cellular cyclophilins requires tht very high amounts of inhibitor be used in ..
  51. The PKCepsilon-regulated oncogenic and tumor suppressor roles of ATF2 in melanoma
    ERIC KIRK LAU; Fiscal Year: 2013
    ..non-genotoxic stress, physiological conditions, where we have observed ATF2 mitochondrial localization without cell death. I will characterize the resulting biological consequences, such as altered mitochondrial respiration or ..
  52. Enhancing radiation and cisplatin HNSCC cell killing by inhibiting mitochondrial
    Lynn Harrison; Fiscal Year: 2013
    ..This work aims to understand more about cell death from mitochondrial damage...
  53. Dual-Receptor Targeted Nanoparticles for Photodynamic Therapy of Brain Cancer
    Ann Marie Broome; Fiscal Year: 2013
    ..to downstream cellular events, such as apoptosis, we will also assess the mechanism of Pc 4-mediated programmed cell death using a mitochondrial membrane potential assay, TUNEL and DNA fragmentation assays, and cell permeability assays,..
  54. Aryl Hydrocarbon Receptor Modulators for the Treatment of Hepatocellular Carcinom
    Siva Kumar Kolluri; Fiscal Year: 2012
    ..SAhRMs will be screened further for their ability to induce AhR- dependent cell death and/or inhibition of cancer cell proliferation...
  55. Ca Signaling in Progression of Amyotrophic Lateral Sclerosis in Skeletal Muscle
    Jingsong Zhou; Fiscal Year: 2013
    ..as a messenger to control their contraction activity, while excessive elevation of Ca inside the cell will cause cell death. We have discovered uncontrolled hyperactive Ca signals in muscle cells of ALS transgenic mouse model...
  56. PARP inhibitor and Redox Catalyst Conjugate for Traumatic Brain Injury
    Kanneganti Murthy; Fiscal Year: 2012
    ..At present, there are no approved therapeutic measures that arrest inflammation and cell death programs that are triggered after cortical contusion...
  57. The Postischemia Inflammatory Syndrome in the Aged Kidney
    KATHERINE JULIA KELLY; Fiscal Year: 2013
    ..in the aged kidney by activating proinflammatory pathways in tubular epithelia ultimately resulting in apoptotic cell death, fibrosis and renal failure...
  58. Impact of Diabetes and Hyperlipidemia on Host Defense
    Hardy Kornfeld; Fiscal Year: 2013
    ..and test the sentinel function of AMF in vivo and in vitro, as well as the impact of DM on AMF activation and cell death. Most human diabetics with TB have type 2 diabetes (T2D), whereas we have so far modeled insulin-deficient type ..
  59. Novel Regenerative Therapy for Myocardial Infarction
    Andrew R Mendelsohn; Fiscal Year: 2011
    ..NRG1b1 also [maintains cardiomyocyte function and] protects cardiomyocytes from cell death by rapid activation of PI3K, eNOS and protein kinase G and increased diastolic calcium levels (Brero et al...
    J Evan Sadler; Fiscal Year: 2013
    ..of leukemia, MDS, myeloproliferative neoplasms, and congenital neutropenia;cell cycle control;programmed cell death in development and malignancy...
  61. Regulation of apoptosis by PI 3-kinase/Akt signaling
    Geoffrey M Cooper; Fiscal Year: 2012
    ..A distinct set of genes, enriched in regulators of programmed cell death, is controlled by continuous PI 3-kinase signaling in proliferating cells...
  62. Beta 2-Microglobulin signaling and targeting in bone metastasis
    Leland W K Chung; Fiscal Year: 2013
    ..as regulators for a series of cell stress response proteins and DNA repair enzymes that ultimately trigger cell death in cancer but not normal cells. Two Specific Aims are proposed in this revised application...
  63. Scavenging of Reactive Oxygen and Nitrogen Species by Cobalamins
    NICOLA ELIZABETH BRASCH; Fiscal Year: 2011
    ..ability to scavenge excess ROS and RNS in primary human aortic endothelial cells and prevent ROS/RNS-initiated cell death will be determined...
  64. Novel Use of Confocal Microscopy on Cultured Porcine Corneas for Pre-Clinical Tes
    Michelle Piehl; Fiscal Year: 2011
    ..e. rabbit tests and BCOP) and substantial tissue-wide cell death (i.e. EpiOcular")...
    Hasan Mukhtar; Fiscal Year: 1999
    ..membrane-localized enzymes, some of which are components of normal signal transduction pathways, leading to cell death. It is postulated that pathways that cause direct vs. indirect cell death in tumors, and for tumor cell death vs...
  66. Significance of Caspase-Mediated Cleavage of PARP-1 in Cell Death
    KAREN DAVID; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Significance of Caspase-Mediated Cleavage of PARP-1 in Cell Death Poly (ADP-ribose) polymerase-1 (PARP-1) maintains cell function by facilitating DNA repair...
  67. Systematic analysis of cell death regulation in mosquitoes
    Lei Zhou; Fiscal Year: 2009
    Title: Systematic analysis of cell death regulation in mosquitoes. Cell death (apoptosis) is an important component of the vector/host immuno-response mechanism...
  68. Vascular smooth muscle apoptosis prevention by glucose
    Frank Brosius; Fiscal Year: 2005
    ..It is therefore not surprising that modulation of these processes affects cell death pathways...
    MYRON JACOBSON; Fiscal Year: 2002
    ..accumulation of reactive oxygen species (ROS), disrupts normal cell signaling pathways often resulting in cell death by apoptosis or necrosis. Calcium signaling is involved in pathways leading to oxidant induced cell death...
    Junying Yuan; Fiscal Year: 1999
    ..In the nematode C. elegans the gene ced -3 is essential for cells to undergo programmed cell death. Interleukin-1b converting enzyme (ICE) has been identified as a vertebrate homologue of Ced-3...
  71. Molecular Adaptation of Hypoxia in Oxygen Sensing Cells
    David Millhorn; Fiscal Year: 2007
    ..Hypoxia leads to reduced oxidative phosphorylation and depletion of cellular ATP, which can result in cell death. Sophisticated mechanisms have evolved which protect cells against hypoxia...
  72. Genes That Regulate Neuronal Cell Death
    Robert Freeman; Fiscal Year: 2009
    b>Cell death is widespread during the development of the nervous system where it helps to ensure that the proper number and types of connections are formed between neurons and their targets...
  73. A Novel Cell Death Pathway Induced by Galectin-1
    Linda Baum; Fiscal Year: 2004
    b>Cell death is a critical regulatory process in development, in homeostasis, and in disease. Many cell death triggers have been identified, although little is known about many of the molecular pathways that lead to cell death...
  74. Dissecting the Molecular Pathway of Aponecrosis
    Junying Yuan; Fiscal Year: 2005
    ..Aponecrosis is defined as caspase-independent cell death induced by the death receptors such as Fas and TNFalpha receptors...
  75. Signaling and Therapeutics in Cell Death and Survival
    Zahra Zakeri; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): This application requests funds to support the International Conference on Cell Death, to be held at the hotel Marbella resort Maitencillo, Chile http://www.marbella.cl/ing/home...
  76. Mechanisms of Sensory Hair Cell Death and Survival
    Lisa L Cunningham; Fiscal Year: 2010
    ..The goal of this research program is to understand the molecular mechanisms underlying hair cell death and survival...