cell cycle


Summary: The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.

Top Publications

  1. pmc The DNA-damage response in human biology and disease
    Stephen P Jackson
    The Gurdon Institute and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Nature 461:1071-8. 2009
  2. pmc p21 in cancer: intricate networks and multiple activities
    Tarek Abbas
    Department of Biochemistry and Molecular Genetics, University of Virginia, School of Medicine, 1340 Jefferson Park Avenue, Charlottesville, VA 22908, USA
    Nat Rev Cancer 9:400-14. 2009
  3. ncbi A DNA damage checkpoint response in telomere-initiated senescence
    Fabrizio d'Adda di Fagagna
    1 The Wellcome Trust Cancer Research UK Institute of Cancer and Developmental Biology, University of Cambridge, Cambridge CB2 1QR, UK 2 Present address IFOM FIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy
    Nature 426:194-8. 2003
  4. ncbi p53 in health and disease
    Karen H Vousden
    Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK
    Nat Rev Mol Cell Biol 8:275-83. 2007
  5. ncbi Anticancer activities of histone deacetylase inhibitors
    Jessica E Bolden
    Cancer Immunology Program, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne 3002, Victoria, Australia
    Nat Rev Drug Discov 5:769-84. 2006
  6. ncbi ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
    Shuhei Matsuoka
    Department of Genetics and Center for Genetics and Genomics, Brigham and Women s Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Science 316:1160-6. 2007
  7. ncbi Microtubules as a target for anticancer drugs
    Mary Ann Jordan
    University of California Santa Barbara, Santa Barbara, California 93106, USA
    Nat Rev Cancer 4:253-65. 2004
  8. ncbi In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
    Lyubomir T Vassilev
    Department of Discovery Oncology, Roche Research Center, Hoffmann La Roche, Inc, Nutley, NJ 07110, USA
    Science 303:844-8. 2004
  9. ncbi The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
    J W Harper
    Verna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, Texas 77030
    Cell 75:805-16. 1993
  10. doi Cell cycle, CDKs and cancer: a changing paradigm
    Marcos Malumbres
    Cell Division and Cancer Group, Molecular Oncology Programme, Centro Nacional de Investigaciones Oncologicas CNIO, 28029 Madrid, Spain
    Nat Rev Cancer 9:153-66. 2009

Detail Information

Publications375 found, 100 shown here

  1. pmc The DNA-damage response in human biology and disease
    Stephen P Jackson
    The Gurdon Institute and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Nature 461:1071-8. 2009
    ..Our improving understanding of DNA-damage responses is providing new avenues for disease management...
  2. pmc p21 in cancer: intricate networks and multiple activities
    Tarek Abbas
    Department of Biochemistry and Molecular Genetics, University of Virginia, School of Medicine, 1340 Jefferson Park Avenue, Charlottesville, VA 22908, USA
    Nat Rev Cancer 9:400-14. 2009
    One of the main engines that drives cellular transformation is the loss of proper control of the mammalian cell cycle. The cyclin-dependent kinase inhibitor p21 (also known as p21WAF1/Cip1) promotes cell cycle arrest in response to many ..
  3. ncbi A DNA damage checkpoint response in telomere-initiated senescence
    Fabrizio d'Adda di Fagagna
    1 The Wellcome Trust Cancer Research UK Institute of Cancer and Developmental Biology, University of Cambridge, Cambridge CB2 1QR, UK 2 Present address IFOM FIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy
    Nature 426:194-8. 2003
    ..Thus, we propose that telomere-initiated senescence reflects a DNA damage checkpoint response that is activated with a direct contribution from dysfunctional telomeres...
  4. ncbi p53 in health and disease
    Karen H Vousden
    Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK
    Nat Rev Mol Cell Biol 8:275-83. 2007
    ..Although the function of p53 as a tumour suppressor ensures that we can't live without it, an integrated view of p53 suggests that not all of its functions are conducive to a long and healthy life...
  5. ncbi Anticancer activities of histone deacetylase inhibitors
    Jessica E Bolden
    Cancer Immunology Program, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne 3002, Victoria, Australia
    Nat Rev Drug Discov 5:769-84. 2006
  6. ncbi ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
    Shuhei Matsuoka
    Department of Genetics and Center for Genetics and Genomics, Brigham and Women s Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Science 316:1160-6. 2007
    ..This database paints a much broader landscape for the DDR than was previously appreciated and opens new avenues of investigation into the responses to DNA damage in mammals...
  7. ncbi Microtubules as a target for anticancer drugs
    Mary Ann Jordan
    University of California Santa Barbara, Santa Barbara, California 93106, USA
    Nat Rev Cancer 4:253-65. 2004
  8. ncbi In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
    Lyubomir T Vassilev
    Department of Discovery Oncology, Roche Research Center, Hoffmann La Roche, Inc, Nutley, NJ 07110, USA
    Science 303:844-8. 2004
    ..These compounds bind MDM2 in the p53-binding pocket and activate the p53 pathway in cancer cells, leading to cell cycle arrest, apoptosis, and growth inhibition of human tumor xenografts in nude mice.
  9. ncbi The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
    J W Harper
    Verna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, Texas 77030
    Cell 75:805-16. 1993
    ..Cotransfection experiments indicate that CIP1 and SV40 T antigen function in a mutually antagonistic manner to control cell cycle progression.
  10. doi Cell cycle, CDKs and cancer: a changing paradigm
    Marcos Malumbres
    Cell Division and Cancer Group, Molecular Oncology Programme, Centro Nacional de Investigaciones Oncologicas CNIO, 28029 Madrid, Spain
    Nat Rev Cancer 9:153-66. 2009
    Tumour-associated cell cycle defects are often mediated by alterations in cyclin-dependent kinase (CDK) activity. Misregulated CDKs induce unscheduled proliferation as well as genomic and chromosomal instability...
  11. doi Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis
    Jesper V Olsen
    Department of Proteomics and Signal Transduction, Max Planck Institute for Biochemistry, Am Klopferspitz 18, D 82152 Martinsried near Munich, Germany
    Sci Signal 3:ra3. 2010
    ..high-resolution mass spectrometry-based proteomics to investigate the proteome and phosphoproteome of the human cell cycle on a global scale and quantified 6027 proteins and 20,443 unique phosphorylation sites and their dynamics...
  12. ncbi DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
    Jirina Bartkova
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Nature 434:864-70. 2005
    ..Mutations compromising this checkpoint, including defects in the ATM-Chk2-p53 pathway, might allow cell proliferation, survival, increased genomic instability and tumour progression...
  13. ncbi The economics of ribosome biosynthesis in yeast
    J R Warner
    Dept of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, New York, Bronx, NY 10461, USA
    Trends Biochem Sci 24:437-40. 1999
    ..This is entrusted to a number of signal transduction pathways that can abruptly induce or silence the ribosomal genes, leading to major implications for the expression of other genes as well...
  14. ncbi Proliferation, cell cycle and apoptosis in cancer
    G I Evan
    UCSF Cancer Center, 2340 Sutter Street, San Francisco, California 94143-0875, USA
    Nature 411:342-8. 2001
    ..Adroit targeting of these critical events should have potent and specific therapeutic consequences...
  15. ncbi The cell biology of neurogenesis
    Magdalena Gotz
    Institute for Stem Cell Research, GSF National Research Center for Environment and Health, Ingolstadter Landstrasse 1, D 85764 Neuherberg Munich, Germany
    Nat Rev Mol Cell Biol 6:777-88. 2005
    ..Here, we discuss how these features change during development from neuroepithelial to radial glial cells, and how this transition affects cell fate and neurogenesis...
  16. ncbi Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors
    Judith Campisi
    Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Cell 120:513-22. 2005
    Cells from organisms with renewable tissues can permanently withdraw from the cell cycle in response to diverse stress, including dysfunctional telomeres, DNA damage, strong mitogenic signals, and disrupted chromatin...
  17. doi Visualizing spatiotemporal dynamics of multicellular cell-cycle progression
    Asako Sakaue-Sawano
    Laboratory for Cell Function and Dynamics, Advanced Technology Development Group, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako City, Saitama 351 0198, Japan
    Cell 132:487-98. 2008
    ..These mice and cell lines will serve as model systems permitting unprecedented spatial and temporal resolution to help us better understand how the cell cycle is coordinated with various biological events.
  18. ncbi The Ki-67 protein: from the known and the unknown
    T Scholzen
    Division of Molecular Immunology, Research Center Borstel, Germany
    J Cell Physiol 182:311-22. 2000
    ..The fact that the Ki-67 protein is present during all active phases of the cell cycle (G(1), S, G(2), and mitosis), but is absent from resting cells (G(0)), makes it an excellent marker for ..
  19. doi A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice
    Cristina Escribano-Diaz
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
    Mol Cell 49:872-83. 2013
    ..Here we show that 53BP1 is an inhibitor of BRCA1 accumulation at DSB sites, specifically in the G1 phase of the cell cycle. ATM-dependent phosphorylation of 53BP1 physically recruits RIF1 to DSB sites, and we identify RIF1 as the ..
  20. pmc Significance analysis of microarrays applied to the ionizing radiation response
    V G Tusher
    Departments of Medicine and Biochemistry, Stanford University, 269 Campus Drive, Center for Clinical Sciences Research 1115, Stanford, CA 94305-5151, USA
    Proc Natl Acad Sci U S A 98:5116-21. 2001
    ..Of the 34 genes, 19 were involved in cell cycle regulation and 3 in apoptosis...
  21. ncbi BRAFE600-associated senescence-like cell cycle arrest of human naevi
    Chrysiis Michaloglou
    Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Nature 436:720-4. 2005
    ..Here we show that sustained BRAF(V600E) expression in human melanocytes induces cell cycle arrest, which is accompanied by the induction of both p16(INK4a) and senescence-associated acidic beta-..
  22. pmc A microRNA component of the p53 tumour suppressor network
    Lin He
    Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nature 447:1130-4. 2007
    ..Ectopic expression of miR-34 induces cell cycle arrest in both primary and tumour-derived cell lines, which is consistent with the observed ability of miR-34 to ..
  23. ncbi Cancer cell cycles
    C J Sherr
    Howard Hughes Medical Institute, Department of Tumor Cell Biology, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    Science 274:1672-7. 1996
    ..that govern phosphorylation of the retinoblastoma protein (RB) and control exit from the G1 phase of the cell cycle, are so frequent in human cancers that inactivation of this pathway may well be necessary for tumor development...
  24. doi MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma
    F Fornari
    1Dipartimento di Medicina Interna e Gastroenterologia e Centro di Ricerca Biomedica Applicata, Universita di Bologna, Policlinico S Orsola, Bologna, Italy
    Oncogene 27:5651-61. 2008
    ..These findings establish a basis toward the development of therapeutic strategies aimed at blocking miR-221 in HCC...
  25. ncbi The spindle-assembly checkpoint in space and time
    Andrea Musacchio
    Department of Experimental Oncology, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    Nat Rev Mol Cell Biol 8:379-93. 2007
    ..These studies are finally starting to reveal the mechanisms of checkpoint activation and silencing during mitotic progression...
  26. pmc NF-kappaB-YY1-miR-29 regulatory circuitry in skeletal myogenesis and rhabdomyosarcoma
    Huating Wang
    Department of Molecular Virology, Human Cancer Genetics Program, The Ohio State University, Columbus, OH 43210, USA
    Cancer Cell 14:369-81. 2008
    ..Together, these results identify a NF-kappaB-YY1-miR-29 regulatory circuit whose disruption may contribute to RMS...
  27. ncbi Coordinated transcription of key pathways in the mouse by the circadian clock
    Satchidananda Panda
    The Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA
    Cell 109:307-20. 2002
    ..Importantly, rate-limiting steps in these various pathways were key sites of circadian control, highlighting the fundamental role that circadian clocks play in cellular and organismal physiology...
  28. pmc Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization
    J A Diehl
    Howard Hughes Medical Institute, St Jude Children s Research Hospital, Memphis, Tennessee 38105 USA
    Genes Dev 12:3499-511. 1998
    ..at position 286 and that is refractory to phosphorylation by GSK-3beta remained in the nucleus throughout the cell cycle. Overexpression of an active, but not a kinase-defective, form of GSK-3beta in mouse fibroblasts caused a ..
  29. ncbi Cellular senescence: when bad things happen to good cells
    Judith Campisi
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, California 94720, USA
    Nat Rev Mol Cell Biol 8:729-40. 2007
  30. ncbi Principles of CDK regulation
    D O Morgan
    Department of Physiology, University of California, San Francisco 94143 0444
    Nature 374:131-4. 1995
    As key regulators of the cell cycle, the cyclin-dependent kinases must be tightly regulated by extra- and intracellular signals...
  31. doi Mammalian cell-cycle regulation: several Cdks, numerous cyclins and diverse compensatory mechanisms
    A Satyanarayana
    Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute Frederick, Frederick, MD 21702 1201, USA
    Oncogene 28:2925-39. 2009
    ..The most astonishing observation is that Cdk2 is dispensable for the regulation of the mitotic cell cycle with both Cdk4 and Cdk1 covering for Cdk2's functions...
  32. ncbi Regulation of DNA double-strand break repair pathway choice
    Meena Shrivastav
    Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine and Cancer Center, Albuquerque, NM 87131, USA
    Cell Res 18:134-47. 2008
    ..them differs widely among species, between different cell types of a single species, and during different cell cycle phases of a single cell type...
  33. ncbi DMC1: a meiosis-specific yeast homolog of E. coli recA required for recombination, synaptonemal complex formation, and cell cycle progression
    D K Bishop
    Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138
    Cell 69:439-56. 1992
    ..dmc1 mutations confer prophase arrest. Additional evidence suggests that arrest occurs at a meiosis-specific cell cycle "checkpoint" in response to a primary defect in prophase chromosome metabolism...
  34. ncbi Chk1 and Chk2 kinases in checkpoint control and cancer
    Jiri Bartek
    Department of Cell Cycle and Cancer, Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark
    Cancer Cell 3:421-9. 2003
    ..enhanced genetic instability is fueled by defects in the genome maintenance mechanisms including DNA repair and cell cycle checkpoint pathways...
  35. ncbi DNA double-strand breaks: signaling, repair and the cancer connection
    K K Khanna
    The Queensland Institute of Medical Research, and Department of Pathology, University of Queensland, PO Royal Brisbane Hospital, Brisbane, Queensland, Australia
    Nat Genet 27:247-54. 2001
    ..Moreover, we discuss how tumor suppressor proteins such as p53, ATM, Brca1 and Brca2 have been linked to such pathways, and how accumulating evidence is connecting deficiencies in cellular responses to DNA DSBs with tumorigenesis...
  36. ncbi Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints
    Aziz Sancar
    Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7260, USA
    Annu Rev Biochem 73:39-85. 2004
    ..and restoration of the continuity of the DNA duplex; (b) activation of a DNA damage checkpoint, which arrests cell cycle progression so as to allow for repair and prevention of the transmission of damaged or incompletely replicated ..
  37. ncbi Cell cycle regulation by the intrinsically disordered proteins p21 and p27
    Mi Kyung Yoon
    St Jude Children s Research Hospital, Department of Structural Biology, 262 Danny Thomas Place, Memphis TN, 38105, U S A
    Biochem Soc Trans 40:981-8. 2012
    ..In the present paper, we review disorder-mediated cell cycle regulation by two intrinsically disordered proteins, p21 and p27...
  38. pmc BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures
    Y Wang
    Verna and Mars McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Genes Dev 14:927-39. 2000
    ..Collectively, these results suggest that BRCA1 may function as a coordinator of multiple activities required for maintenance of genomic integrity during the process of DNA replication and point to a central role for BRCA1 in DNA repair...
  39. pmc Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA
    Syuzo Kaneko
    Howard Hughes Medical Institute, New York University School of Medicine, New York, 10016, USA
    Genes Dev 24:2615-20. 2010
    ..Ezh2 is phosphorylated by cyclin-dependent kinase 1 (CDK1) at threonine residues 345 and 487 in a cell cycle-dependent manner...
  40. doi E2F1-regulated microRNAs impair TGFbeta-dependent cell-cycle arrest and apoptosis in gastric cancer
    Fabio Petrocca
    Department of Molecular Virology, Immunology and Medical Genetics, Human Cancer Genetics Program, Ohio State University, 460 West 12th Avenue, Columbus, OH 43210, USA
    Cancer Cell 13:272-86. 2008
    ..Together, these results suggest that the miR-106b-25 cluster is involved in E2F1 posttranscriptional regulation and may play a key role in the development of TGFbeta resistance in gastric cancer...
  41. pmc A skin microRNA promotes differentiation by repressing 'stemness'
    Rui Yi
    Howard Hughes Medical Institute, The Rockefeller University, New York City, New York 10065, USA
    Nature 452:225-9. 2008
    ..Our findings suggest that miR-203 defines a molecular boundary between proliferative basal progenitors and terminally differentiating suprabasal cells, ensuring proper identity of neighbouring layers...
  42. ncbi p53, the cellular gatekeeper for growth and division
    A J Levine
    Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, New Jersey 08544, USA
    Cell 88:323-31. 1997
  43. ncbi Ubiquitin ligases: cell-cycle control and cancer
    Keiichi I Nakayama
    Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Fukuoka 812 8582, Japan
    Nat Rev Cancer 6:369-81. 2006
    A driving force of the cell cycle is the activation of cyclin-dependent kinases (CDKs), the activities of which are controlled by the ubiquitin-mediated proteolysis of key regulators such as cyclins and CDK inhibitors...
  44. ncbi A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
    M Serrano
    Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, New York 11724
    Nature 366:704-7. 1993
    ..this family and their consequent phosphorylation of critical substrates promotes orderly progression through the cell cycle. The complexes formed by CDK4 and the D-type cyclins have been strongly implicated in the control of cell ..
  45. ncbi VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo
    Elizabeth A Harrington
    Vertex Pharmaceuticals Europe Limited, 88 Milton Park, Abingdon, Oxfordshire, OX14 4RY, UK
    Nat Med 10:262-7. 2004
    ..Our data indicate that Aurora kinase inhibition provides a new approach for the treatment of multiple human malignancies...
  46. ncbi Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression
    Jiyong Liang
    Molecular and Cell Biology, Sunnybrook and Women s Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    Cell Cycle 2:339-45. 2003
    ..PKB triggers a network that positively regulates G1/S cell cycle progression through inactivation of GSK3-beta, leading to increased cyclin D1, and inhibition of Forkhead family ..
  47. pmc Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair
    Agata Smogorzewska
    Department of Genetics, Howard Hughes Medical Institute, Center for Genetics and Genomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Cell 129:289-301. 2007
    ..Mutation in FANCI is responsible for loss of a functional FA pathway in a patient with Fanconi anemia complementation group I...
  48. ncbi Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy
    F Chang
    Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville 27858, USA
    Leukemia 17:590-603. 2003
    ..However, more recent evidence has also associated this pathway with regulation of cell cycle progression...
  49. doi Long non-coding RNA UCA1 regulated cell cycle distribution via CREB through PI3-K dependent pathway in bladder carcinoma cells
    Chen Yang
    Center for Molecular Medicine, The First Affiliated Hospital, School of Medicine, Xi an Jiaotong University, 76 West Yanta Road, 710061 Xi an, China
    Gene 496:8-16. 2012
    ..After knocking down of UCA1 in BLZ-211 cells, several cell cycle-related genes (CDKN2B, EP300 and TGFβ-2) were screened by microarray assay and validated by real-time PCR...
  50. pmc Ubiquitylation and proteasomal degradation of the p21(Cip1), p27(Kip1) and p57(Kip2) CDK inhibitors
    Zhimin Lu
    Brain Tumor Center and Department of Neuro Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Cell Cycle 9:2342-52. 2010
    ..role in the precise regulation of cyclin-dependent kinase (CDK) activity, which is instrumental to proper cell cycle progression...
  51. pmc The forkhead transcription factor FOXM1 controls cell cycle-dependent gene expression through an atypical chromatin binding mechanism
    Xi Chen
    University of Manchester, Manchester, United Kingdom
    Mol Cell Biol 33:227-36. 2013
    ..In keeping with its previous association with cell cycle control, we demonstrate that FOXM1 binds and regulates a group of genes which are mainly involved in controlling ..
  52. ncbi AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1
    R H Medema
    Department of Hematology, University Medical Center, Utrecht, The Netherlands
    Nature 404:782-7. 2000
    ..We conclude that AFX-like proteins are involved in cell-cycle regulation and that inactivation of these proteins is an important step in oncogenic transformation...
  53. pmc Ink4a/Arf expression is a biomarker of aging
    Janakiraman Krishnamurthy
    Department of Medicine, The Lineberger Comprehensive Cancer Center, The University of North Carolina School of Medicine, Chapel Hill, North Carolina, 27599 7295, USA
    J Clin Invest 114:1299-307. 2004
    ..all rodent tissues with advancing age, while there is little or no change in the expression of other related cell cycle inhibitors...
  54. pmc CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle
    Maximina H Yun
    Division of Protein and Nucleic Acid Chemistry, MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Nature 459:460-3. 2009
    The repair of DNA double-strand breaks (DSBs) is tightly regulated during the cell cycle. In G1 phase, the absence of a sister chromatid means that repair of DSBs occurs through non-homologous end-joining or microhomology-mediated end-..
  55. pmc The C terminus of talin links integrins to cell cycle progression
    Pengbo Wang
    Wellcome Trust Centre for Cell Matrix Research, University of Manchester, Manchester M13 9PT, England, UK
    J Cell Biol 195:499-513. 2011
    ..but not its head domain, restored integrin-mediated FAK phosphorylation, suppressed p21 expression, and rescued cell cycle. Thus, talin recruits and activates focal adhesion proteins required for proliferation via the C terminus of its ..
  56. pmc Hyperdynamic plasticity of chromatin proteins in pluripotent embryonic stem cells
    Eran Meshorer
    National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Dev Cell 10:105-16. 2006
  57. ncbi Gene expression profiling in breast cancer: understanding the molecular basis of histologic grade to improve prognosis
    Christos Sotiriou
    Functional Genomics and Translational Research Unit, Universite Libre de Bruxelles, Brussels, Belgium
    J Natl Cancer Inst 98:262-72. 2006
    ..We examined whether histologic grade was associated with gene expression profiles of breast cancers and whether such profiles could be used to improve histologic grading...
  58. ncbi p21 is a universal inhibitor of cyclin kinases
    Y Xiong
    Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, New York 11724
    Nature 366:701-4. 1993
    ..Furthermore, overexpression of p21 inhibits the proliferation of mammalian cells. Our results indicate that p21 may be a universal inhibitor of cyclin kinases...
  59. pmc Pathways of DNA double-strand break repair during the mammalian cell cycle
    Kai Rothkamm
    Fachrichtung Biophysik, Universitat des Saarlandes, D 66421 Homburg Saar, Germany
    Mol Cell Biol 23:5706-15. 2003
    ..end joining (NHEJ) and homologous recombination (HR) to DNA double-strand break (DSB) repair in different cell cycle phases after physiologically relevant doses of ionizing radiation...
  60. ncbi Liver regeneration
    Nelson Fausto
    Department of Pathology, University of Washington School of Medicine, Seattle, WA 98195 7470, USA
    Hepatology 43:S45-53. 2006
    ..Hepatocytes primed by these agents readily respond to growth factors and enter the cell cycle. Presumably, the increased metabolic demands placed on hepatocytes of the regenerating liver are linked to the ..
  61. pmc p53-Responsive micrornas 192 and 215 are capable of inducing cell cycle arrest
    Christian J Braun
    Department of Molecular Oncology, Göttingen Center of Molecular Biosciences, University of Gottingen, Gottingen, Germany
    Cancer Res 68:10094-104. 2008
    ..hand, miR-192 and its cousin miR-215 can each contribute to enhanced CDKN1A/p21 levels, colony suppression, cell cycle arrest, and cell detachment from a solid support...
  62. doi Prokaryotic ParA-ParB-parS system links bacterial chromosome segregation with the cell cycle
    Jolanta Mierzejewska
    The Institute of Biochemistry and Biophysics, PAS, 02 106 Warsaw, Pawinskiego 5A, Poland
    Plasmid 67:1-14. 2012
    ..Moreover, the chromosomal par systems link chromosome segregation with initiation of DNA replication and the cell cycle.
  63. pmc Single-cell paired-end genome sequencing reveals structural variation per cell cycle
    Thierry Voet
    Department of Human Genetics, KU Leuven, Leuven, 3000, Belgium
    Nucleic Acids Res 41:6119-38. 2013
    ..composition of individual cells is lost, de novo mutations in cells are concealed within the bulk signal and per cell cycle mutation rates and mechanisms remain elusive...
  64. doi 53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress
    Claudia Lukas
    Centre for Genotoxic Stress Research, Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Nat Cell Biol 13:243-53. 2011
    ..Together, these data indicate that restoration of DNA or chromatin integrity at loci prone to replication problems requires mitotic transmission to the next cell generations...
  65. ncbi WAF1, a potential mediator of p53 tumor suppression
    W S El-Deiry
    Oncology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231
    Cell 75:817-25. 1993
    ..These studies define a gene whose expression is directly induced by p53 and that could be an important mediator of p53-dependent tumor growth suppression...
  66. pmc Loss of human Greatwall results in G2 arrest and multiple mitotic defects due to deregulation of the cyclin B-Cdc2/PP2A balance
    Andrew Burgess
    Universités Montpellier 2 et 1, Centre de Recherche de Biochimie Macromoleculaire, Centre National de la Recherche Scientifique UMR 5237, 34293 Montpellier Cedex 5, France
    Proc Natl Acad Sci U S A 107:12564-9. 2010
    ..These results suggest that the balance between cyclin B-Cdc2 and PP2A must be tightly regulated for correct mitotic entry and exit and that Gwl is crucial for mediating this regulation in somatic human cells...
  67. doi miR-15a and miR-16 are implicated in cell cycle regulation in a Rb-dependent manner and are frequently deleted or down-regulated in non-small cell lung cancer
    Nora Bandi
    Institute of Pathology, University of Bern, Bern, Switzerland
    Cancer Res 69:5553-9. 2009
    ..Two miRNAs, miR-15a and miR-16, which are located at chromosome 13q14, have been implicated in cell cycle control and apoptosis, but little information is available about their role in solid tumors...
  68. doi CDK inhibitors: cell cycle regulators and beyond
    Arnaud Besson
    Université de Toulouse LBCMCP and CNRS UMR5088, Toulouse, France
    Dev Cell 14:159-69. 2008
    First identified as cell cycle inhibitors mediating the growth inhibitory cues of upstream signaling pathways, the cyclin-CDK inhibitors of the Cip/Kip family p21Cip1, p27Kip1, and p57Kip2 have emerged as multifaceted proteins with ..
  69. ncbi Switching from repression to activation: microRNAs can up-regulate translation
    Shobha Vasudevan
    Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536, USA
    Science 318:1931-4. 2007
    ..Upon cell cycle arrest, the ARE in tumor necrosis factor-alpha (TNFalpha) mRNA is transformed into a translation activation ..
  70. pmc Cell cycle arrest is not senescence
    Mikhail V Blagosklonny
    Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Aging (Albany NY) 3:94-101. 2011
    ..erosion and cytokines, culture shock and mitogenic stimuli, oncogenes and tumor suppressors can induce both cell cycle arrest and cellular senescence...
  71. pmc A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility
    Mark P Keller
    Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53076, USA
    Genome Res 18:706-16. 2008
    ..A cell cycle regulatory module in islets predicts diabetes susceptibility...
  72. pmc Activity of the human immunodeficiency virus type 1 cell cycle-dependent internal ribosomal entry site is modulated by IRES trans-acting factors
    Maricarmen Vallejos
    Laboratorio de Virologia Molecular, Instituto Milenio de Inmunología e Inmunoterapia, Centro de Investigaciones Medicas, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Marcoleta 391, Santiago, Chile
    Nucleic Acids Res 39:6186-200. 2011
    ..genomic RNA harbors an internal ribosome entry site (IRES) that is functional during the G2/M phase of the cell cycle. Here we show that translation initiation mediated by the HIV-1 IRES requires the participation of trans-acting ..
  73. pmc Human CtIP mediates cell cycle control of DNA end resection and double strand break repair
    Pablo Huertas
    Gurdon Institute and Department of Zoology, University of Cambridge, Cambridge CB2 1QN, United Kingdom
    J Biol Chem 284:9558-65. 2009
    ..These results suggest that CDK-mediated control of resection in human cells operates by mechanisms similar to those recently established in yeast...
  74. ncbi p53-mediated activation of miRNA34 candidate tumor-suppressor genes
    Guido T Bommer
    Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, MI 48109 2200, USA
    Curr Biol 17:1298-307. 2007
    ..The role of p53 in transcription of other types of RNAs, such as microRNAs (miRNAs) is essentially unknown...
  75. doi Coordinated regulation of cell cycle transcripts by p53-Inducible microRNAs, miR-192 and miR-215
    Sara A Georges
    Rosetta Inpharmatics LLC, Seattle, Washington WA 98109, USA
    Cancer Res 68:10105-12. 2008
    b>Cell cycle arrest in response to DNA damage is an important antitumorigenic mechanism. MicroRNAs (miRNAs) were recently shown to play key regulatory roles in cell cycle progression...
  76. ncbi SOX2 functions to maintain neural progenitor identity
    Victoria Graham
    Neuroscience Center, Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA
    Neuron 39:749-65. 2003
    ..of SOX2 signaling results in the delamination of neural progenitor cells from the ventricular zone and exit from cell cycle, which is associated with a loss of progenitor markers and the onset of early neuronal differentiation markers...
  77. doi Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity
    Sauveur Michel Maira
    Oncology Disease Area, Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH4002 Basel, Switzerland
    Mol Cancer Ther 7:1851-63. 2008
    ..Collectively, the preclinical data show that NVP-BEZ235 is a potent dual PI3K/mTOR modulator with favorable pharmaceutical properties. NVP-BEZ235 is currently in phase I clinical trials...
  78. doi IFNalpha activates dormant haematopoietic stem cells in vivo
    Marieke A G Essers
    Division of Stem Cells and Cancer, Deutsches Krebsforschungszentrum DKFZ, DKFZ ZMBH Alliance, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Nature 458:904-8. 2009
    ..response to treatment of mice with interferon-alpha (IFNalpha), HSCs efficiently exit G(0) and enter an active cell cycle. HSCs respond to IFNalpha treatment by the increased phosphorylation of STAT1 and PKB/Akt (also known as AKT1), ..
  79. ncbi The Bcl-2 family: roles in cell survival and oncogenesis
    Suzanne Cory
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3050, Victoria, Australia
    Oncogene 22:8590-607. 2003
    ..Finally, it discusses the promise of novel anticancer therapeutics that target these vital regulators...
  80. ncbi Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis
    Yi Tang
    Institute for Cancer Genetics, Surgeons, Columbia University, 1150 St Nicholas Ave, New York, New York 10032, USA
    Mol Cell 24:827-39. 2006
  81. pmc Systematic identification of cell cycle-dependent yeast nucleocytoplasmic shuttling proteins by prediction of composite motifs
    Shunichi Kosugi
    Institute for Advanced Biosciences, Keio University, Tsuruoka, Japan
    Proc Natl Acad Sci U S A 106:10171-6. 2009
    The cell cycle-dependent nucleocytoplasmic transport of proteins is predominantly regulated by CDK kinase activities; however, it is currently difficult to predict the proteins thus regulated, largely because of the low prediction ..
  82. doi The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer
    Joanne Smith
    Beatson Institute for Cancer Research, Garscube Estate, Glasgow, UK
    Adv Cancer Res 108:73-112. 2010
    ..Here, we review current understanding of the organization and functions of the ATM-Chk2 and ATR-Chk1 pathways and the prospects for targeting DNA damage signaling processes for therapeutic purposes...
  83. doi More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance
    Jiri Lukas
    Centre for Genotoxic Stress Research, Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Nat Cell Biol 13:1161-9. 2011
    ..Recent research has provided insights into these issues and suggests that chromatin responses induced by DNA damage are not simply the accumulation of 'nuclear foci' but are mechanisms required to guard genome integrity...
  84. pmc Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2
    H Christian Reinhardt
    David H Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Curr Opin Cell Biol 21:245-55. 2009
    In response to DNA damage eukaryotic cells activate cell cycle checkpoints -- complex kinase signaling networks that prevent further progression through the cell cycle...
  85. ncbi Liver regeneration: from myth to mechanism
    Rebecca Taub
    University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19004, USA
    Nat Rev Mol Cell Biol 5:836-47. 2004
    ..So what is known about this process at present and which questions remain?..
  86. doi Epigenetic inheritance during the cell cycle
    Aline V Probst
    Laboratory of Nuclear Dynamics and Genome Plasticity, UMR218 Centre National de la Recherche Scientifique Institut Curie, 26, rue d Ulm, 75231 Paris Cedex 05, France
    Nat Rev Mol Cell Biol 10:192-206. 2009
    ..Understanding the dynamics and stability of these marks through the cell cycle is crucial in maintaining a given chromatin state.
  87. doi MicroRNAs and the cell cycle
    María José Bueno
    Cell Division and Cancer Group, Spanish National Cancer Research Center CNIO, Madrid, Spain
    Biochim Biophys Acta 1812:592-601. 2011
    ..and the alteration of these small, non-coding RNAs may contribute to tumor development by perturbing critical cell cycle regulators...
  88. pmc MicroRNAs in the miR-106b family regulate p21/CDKN1A and promote cell cycle progression
    Irena Ivanovska
    Rosetta Inpharmatics LLC, 401 Terry Ave N, Seattle, WA 98109, USA
    Mol Cell Biol 28:2167-74. 2008
    ..are overexpressed in multiple tumor types and are correlated with the expression of genes that regulate the cell cycle. Consistent with these observations, miR-106b family gain of function promotes cell cycle progression, whereas ..
  89. doi Distinct mitochondrial retrograde signals control the G1-S cell cycle checkpoint
    Edward Owusu-Ansah
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, California 90095, USA
    Nat Genet 40:356-61. 2008
    ..we establish that disruption of complex I of the mitochondrial electron transport chain specifically retards the cell cycle during the G1-S transition...
  90. doi Double-strand break end resection and repair pathway choice
    Lorraine S Symington
    Department of Microbiology and Immunology, Columbia University Medical Center, New York, New York 10032, USA
    Annu Rev Genet 45:247-71. 2011
    ..The choice between these pathways depends on the phase of the cell cycle and the nature of the DSB ends...
  91. ncbi Cell-cycle checkpoints and cancer
    Michael B Kastan
    Department of Hematology Oncology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, Tennessee 38105, USA
    Nature 432:316-23. 2004
    ..These cellular responses are also important for determining toxicities and responses to current cancer therapies, most of which target the DNA...
  92. pmc Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution
    Liam J Holt
    Departments of Physiology and Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA
    Science 325:1682-6. 2009
    ..The gain or loss of phosphorylation sites in rapidly evolving regions could facilitate the evolution of kinase-signaling circuits...
  93. pmc p63-microRNA feedback in keratinocyte senescence
    Pia Rivetti di Val Cervo
    Istituto Dermopatico dell Immacolata Istituto di Ricovero e Cura a Carattere Scientifico, Laboratory of Biochemistry, Department of Experimental Medicine and Biochemical Sciences, and University of Rome Tor Vergata, 00133 Rome, Italy
    Proc Natl Acad Sci U S A 109:1133-8. 2012
    ..Our data also indicate that suppression of miR-138, -181a, -181b, and -130b expression is part of a growth-promoting strategy of ΔNp63α in epidermal proliferating cells...
  94. ncbi SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box
    C Bai
    Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030, USA
    Cell 86:263-74. 1996
    ..Different skp1 mutants arrest cells in either G1 or G2, suggesting a connection between regulation of proteolysis in different stages of the cycle...
  95. doi The cell cycle is a redox cycle: linking phase-specific targets to cell fate
    William C Burhans
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Free Radic Biol Med 47:1282-93. 2009
    ..show that oscillations in oxygen consumption, energy metabolism, and redox state are intimately integrated with cell cycle progression...
  96. pmc Regulatory cohesion of cell cycle and cell differentiation through interlinked phosphorylation and second messenger networks
    Sören Abel
    Biozentrum of the University of Basel, Klingelbergstrasse 50, CH 4054 Basel, Switzerland
    Mol Cell 43:550-60. 2011
    ..Thus, CpdR serves as a crucial link between phosphorylation pathways and c-di-GMP metabolism to mediate protein degradation events that irreversibly and coordinately drive bacterial cell-cycle progression and development...
  97. pmc The MuvB complex sequentially recruits B-Myb and FoxM1 to promote mitotic gene expression
    Subhashini Sadasivam
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02215, USA
    Genes Dev 26:474-89. 2012
    b>Cell cycle progression is dependent on two major waves of gene expression...
  98. ncbi Self-eating and self-killing: crosstalk between autophagy and apoptosis
    M Chiara Maiuri
    INSERM, U848, F 94805 Villejuif, France
    Nat Rev Mol Cell Biol 8:741-52. 2007
    ..On a molecular level, this means that the apoptotic and autophagic response machineries share common pathways that either link or polarize the cellular responses...
  99. ncbi AMP-activated protein kinase induces a p53-dependent metabolic checkpoint
    Russell G Jones
    Abramson Family Cancer Research Institute, Department of Cancer Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Mol Cell 18:283-93. 2005
    ..to glucose deprivation, and cells that have undergone a p53-dependent metabolic arrest can rapidly reenter the cell cycle upon glucose restoration...
  100. doi Mitotic catastrophe: a mechanism for avoiding genomic instability
    Ilio Vitale
    Institut National de la Sante et de la Recherche Medicale INSERM, Villejuif, France
    Nat Rev Mol Cell Biol 12:385-92. 2011
    ..Accordingly, the disruption of mitotic catastrophe precipitates tumorigenesis and cancer progression, and its induction constitutes a therapeutic endpoint...
  101. pmc Proliferating cell nuclear antigen (PCNA): a key factor in DNA replication and cell cycle regulation
    Wojciech Strzalka
    Department of Plant Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, Krakow, Poland
    Ann Bot 107:1127-40. 2011
    ..been found in the nuclei of yeast, plant and animal cells that undergo cell division, suggesting a function in cell cycle regulation and/or DNA replication...

Research Grants70

  1. Optimization of DNA Repair by Abh8
    Lauren Endres; Fiscal Year: 2013
    ..We will use further immunoblots and Q- TOF LC/MS to identify cell cycle and DDR specific post-translational (PT) modifications of Abh8...
  2. Regulation of HSV-1 Gene Expression and Replication by Nuclear Hormone Receptors
    SHAOCHUNG VICTOR HSIA; Fiscal Year: 2013
    ..RCC1/Ran complex is involved in the control of RNA translocation, DNA synthesis, and cell cycle progression via modulating effects on chromatin and nucleosomes...
  3. Role of the Y-Located TSPY Gene in Human Oncogenesis
    Yun Fai Chris Lau; Fiscal Year: 2013
    ..When ectopically expressed, TSPY and TSPX show contrasting properties in cell cycle regulation...
  4. Vitamin D3, Interference with Androgen Signal and Inhibition of Prostate Cancer
    Bandana Chatterjee; Fiscal Year: 2013
    ..Since metastatic prostate cancer is often associated with elevated levels of E2F1, which is a key cell cycle regulatory transcription factor, we designed this project to identify regulatory factors which, through cross-..
  5. DNA Damage and Response in the Bladder Microenvironment.
    Bradley P Dixon; Fiscal Year: 2013
    ..the efficacy of DNA repair under a hyperosmolal bladder microenvironment, and to evaluate the activation of cell cycle checkpoints and apoptosis following DNA damage within a hyperosmolal bladder microenvironment...
  6. Role of Polyamines in MYCN-Amplified Neuroblastoma
    ANDRE BACHMANN; Fiscal Year: 2009
    ..Our initial results showed that the depletion of polyamines in MYCN-amplified NB cells caused G1 cell cycle arrest and affected p27Kip1 levels, retinoblastoma protein Rb phosphorylation, and most intriguingly, blocked ..
  7. Translational Machinery in Stress Signaling and Tumor Suppression
    THOMAS J contact BEGLEY; Fiscal Year: 2010
    ..regulation has recently been associated with the DNA damage response, and appears to promote efficient cell cycle arrest and DNA repair after damage1...
    Terence S Dermody; Fiscal Year: 2013
    ..We hypothesize that a1s-induced cell cycle arrest leads to apoptosis of target cells that are in turn engulfed by phagocytic ceils to initiate systemic ..
  9. Collagen X and heparan sulfate proteoglycan in the hematopoietic stem cell niche.
    ELIZABETH G SWEENEY; Fiscal Year: 2012
    ..a posttranslational modification, transcriptional regulation of differentiation, growth hormones, respiration, cell cycle, cell death, spermatogenesis, obesity, stress, immunology, eye development, and dinosaur paleobiology...
  10. Prostate cancer chemoprevention by penta-galloyl-glucose
    Junxuan Lu; Fiscal Year: 2013
    ..of the p53 tumor suppressor and inactivating the Stat3 oncogenic signaling, associated with cyclin D1 (cell cycle) and Bcl-xL/Mcl-1 (cell survival) down regulation...
  11. Genistein, microRNAs and kidney cancer
    Rajvir Dahiya; Fiscal Year: 2013
    ..Alterations in cell growth will be assessed by monitoring cell proliferation, cell cycle distribution, apoptosis and in vitro invasion...
    DHAN V KALVAKOLANU; Fiscal Year: 2013
    ..One of them is the death associated protein kinase1 (DAPK1), an important regulator of apoptosis, cell cycle, and metastasis. The expression of dapk1 gene is frequently lost in several human cancers...
  13. Regulation of Cell Signaling by Human Biliverdin Reductase
    Mahin D Maines; Fiscal Year: 2013
    ..Presently, we hypothesize that BVR functions in defining cytoskeletal organization and regulation of cell cycle progression events that are mediated by growth factors...
  14. Molecular mechanisms of lung disease in ataxia telangiectasia
    JoAnn M Sekiguchi; Fiscal Year: 2013
    ..a "master controller" of cellular responses to DNA double strand breaks, and it is required for activation of cell cycle checkpoints, direct DNA repair events and/or apoptosis...
  15. Bioflavonoid Effects on EGF Signaling and Cell Cycle Pathways in Prostate Cancer
    ..Microarray and real time PCR (qPCR) studies demonstrate that L, BMHPC or ZN-2 regulate cell cycle gene (CCNA2, CCNE2, CDKN1B, CDC25A, PCNA, PLK1) expression in PC-3 human prostate cancer cells in addition to a ..
    Howard B Lieberman; Fiscal Year: 2013
    ..evolutionarily conserved gene has multiple functions needed for the cellular response to DNA damage, including cell cycle checkpoints, DNA repair and pro-apoptotic activities...
  17. Interplay Between Tissue Architecture and Nuclear Organization in the DNA Damage
    Pierre Alexandre Vidi; Fiscal Year: 2013
    ..have evolved elaborate DNA damage response (DDR) mechanisms to sense DSBs, activate repair pathways, and control cell cycle progression to prevent the propagation of genomic instability...
  18. 4th ASM Conference on Prokaryotic Cell Biology and Development
    Susan S Golden; Fiscal Year: 2012
    ..systems: Escherichia coli (cell division, cytoskeletal structures, cell wall biosynthesis), Bacillus subtilis (cell cycle regulation, cytoskeletal structures, development, biofilm formation, cell wall biosynthesis), Caulobacter ..
  19. Cell Cycle Regulation and Adult T Cell Leukemia
    Chou Zen Giam; Fiscal Year: 2013
    ..The study will provide molecular insights that can lead to the development of treatment strategies for human cancer ..
  20. Genistein and Prostate Cancer
    Rajvir Dahiya; Fiscal Year: 2010
    ..Specific Aim # 1. To investigate whether genistein can suppress prostate cancer growth through cell cycle arrest, cyclin genes and apoptosis...
  21. Novel Zebrafish Models to Study Toxicity of PCBs and Pesticides During Pregnancy
    Lisa Satterwhite; Fiscal Year: 2009
    ..mechanism: activation of the aryl hydrocarbon receptor (AHR) signaling pathway which leads to tissue specific cell cycle arrest...
  22. DNA Damage Checkpoint and Cancer
    Toru Ouchi; Fiscal Year: 2012
    ..forms of genotoxic stress, cells activate complex protein kinase signaling pathways, such as ATM, to arrest the cell cycle, recruit DNA repair machinery, and re-enter the cell cycle once the damage is resolved, or if the damage is ..
  23. Identifying all Meckel-like ciliopathy genes by established total exome capture a
    Friedhelm Hildebrandt; Fiscal Year: 2010
    ..9 genes (NPHP1-NPHP9) as causing retinal- renal ciliopathies, implicating Wnt signaling, hedgehog signaling, and cell cycle regulation in their pathogeneses...
  24. Histone Chaperones in Angiogenesis
    Soumen Paul; Fiscal Year: 2012
    ..signal-induced transcription at the Vegfr1 locus is dependent on the function of a histone chaperone, histone cell cycle regulation defective homolog A (HIRA)...
  25. Pluripotent stem cell-derived HSCs: improvements and molecular mechanisms
    Patrick Cahan; Fiscal Year: 2013
    ..research in the areas of stem cell biology, development, hematopoiesis, chemical biology, transcription, cell cycle, and cancer genetics...
  26. Deregulated lipid metabolism in stroke
    Robert J Dempsey; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Post-mitotic neurons can enter into the cell cycle after stroke but die instead of proliferating...
  27. Aryl Hydrocarbon Receptor Modulators for the Treatment of Hepatocellular Carcinom
    Siva Kumar Kolluri; Fiscal Year: 2012
    ..as the mediator of toxicity of various dioxins, recent studies have identified roles for the AhR in apoptosis, cell cycle regulation, and tumor suppression, all of which make the AhR a potentially attractive molecular target for ..
  28. Novel Regenerative Therapy for Myocardial Infarction
    Andrew R Mendelsohn; Fiscal Year: 2011
    ..mammalian hearts contain endogenous adult mononucleated cardiomyocytes that can be stimulated to re-enter the cell cycle, divide and redifferentiate when exposed to neuregulin-1 beta-1 (NRG1b1), an EGF family growth factor that ..
  29. Hepatitis B virus replication and DDB1
    Betty L Slagle; Fiscal Year: 2013
    ..In this manner, DDB1 regulates diverse cellular functions such as DNA replication, cell cycle, innate immunity, and damaged DNA repair...
    ELIZABETH ANN LEIBOLD; Fiscal Year: 2013
    ..regulation of RNA-binding activity by cyclin-dependent kinase 1 (CDK1) phosphorylation during the cell cycle. Our goals are to determine how iron regulates IRP2 stability and how IRP2 phosphorylation regulates cell cycle ..
    J Evan Sadler; Fiscal Year: 2013
    ..morphogenesis;pathogenesis of leukemia, MDS, myeloproliferative neoplasms, and congenital neutropenia;cell cycle control;programmed cell death in development and malignancy...
  32. 14th International Workshop on Ataxia-Telangiectasia and ATM
    Richard A Gatti; Fiscal Year: 2010
    ..major role of ATM appears to be in the recognition and repair of double strand DNA breaks, through coordinated cell cycle checkpoint control and signaling to hundreds of downstream targets...
  33. The function of ATM protein in the biology of the adult neuron CNS:
    Karl Herrup; Fiscal Year: 2013
    ..Our outcome measures will include dendritic morphology, synaptic physiology, cell cycle regulation and cell survival...
  34. Integrating stress MAP kinase signaling with DNA replication origin licensing
    Jeanette Gowen Cook; Fiscal Year: 2013
    ..reasons we seek to define molecular mechanisms that govern DNA replication competence and coordination with cell cycle control...
  35. Protein composition and interactions of telemeric chromatin
    Michael P Killoran; Fiscal Year: 2010
    ..established scientists in the cancer biology field, such as the Mechanisms and Models of Cancer Meeting and Cell Cycle Meeting...
  36. Role of Matrix Metalloproteinase-1 in Endothelial Cell Senescence
    Catherine D Mao; Fiscal Year: 2010
    ..We have previously shown that lithium induces a cell cycle arrest in primary endothelial cells associated with the activation of the tumor suppressor p53 and p21cip ..
  37. Chemoprevention of urinary bladder carcinogenesis by flavokawain A
    Xiaolin Zi; Fiscal Year: 2012
    ..We hypothesize flavokawain A has chemopreventive effects on bladder epithelium via enhancing cell cycle regulation and increasing the sensitivity of apoptotic mechanisms...
  38. PKC delta and cell renewal in irradiated taste epithelium
    MARY ELAINE REYLAND; Fiscal Year: 2012
    ..We will also define the contribution of radiation-induced cell cycle arrest, DNA repair and apoptosis to taste cell renewal following injury...
  39. The unique role of B-Raf in murine cardiac development and postnatal function
    Natasha N Chattergoon; Fiscal Year: 2013
    ..vasodilator, is potent inhibitor of VSMC proliferation in vitro by stimulating cAMP pathways that affect cell cycle regulation. I began my postdoctoral training in Dr. Kent L...
  40. Link of beta cell proliferation and type 2 diabetes to epigenetic regulation
    Xianxin Hua; Fiscal Year: 2013
    ..It is hypothesized that menin normally suppresses beta cell proliferation through repressing transcription of cell cycle regulators, such as GLP-1-induced cyclin A, in concert with epigenetic regulator PRMT5, and that Men1 inhibition ..
  41. MicroRNAs in the Progression and Metastisis of Prostate Cancer
    Rajvir Dahiya; Fiscal Year: 2013
    ..Changes in cell growth will be analyzed by monitoring proliferation, cell cycle distribution, apoptosis and in vitro invasion...
  42. Functional study of C53 protein as a novel regulator of checkpoint kinases
    Honglin Li; Fiscal Year: 2012
    Our long-term goal is to elucidate the roles of a novel protein C53 in regulation of cell cycle progression and DNA damage response, and to explore potential utilization of this novel protein as a novel therapeutic target...
  43. AKAP Regulation of PKA Targeting in the Heart
    Meredith Bond; Fiscal Year: 2009
    ..Chd8 interacts with several factors that mediate cell cycle progression, apoptosis and survival, We identified Chd8 as an AKAP by phage display, by co- immunoprecipitation ..
  44. Beta-cell Proliferation
    Fredric E Wondisford; Fiscal Year: 2013
    ..Of these mechanisms, [unreadable]-cell proliferation and regulation of cell cycle appear predominant in establishing and determining [unreadable]-cell mass...
    Vincent W Yang; Fiscal Year: 2013
    ..KLF4 is a potent inhibitor of cell proliferation in vitro and does so by eliciting several cell cycle checkpoint responses...
  46. Statins &Lymphoid Malignancy Risk in a Large Multi-Site Population-Based Cohort
    Marianne Ulcickas Yood; Fiscal Year: 2013
    ..They have been found to arrest cell cycle progression, induce apoptosis, and suppress angiogenesis and inflammation...
  47. ATM Controls Genomic Stability in Pluripotent Stem Cells
    JASON MARK BECKTA; Fiscal Year: 2013
    ..Decatenation failure leads to a G2/M arrest via a distinct cell cycle checkpoint Activation of this checkpoint prevents aberrant daughter cell formation...
  48. Preclinical testing of a novel PDK1 inhibitor for treating vestibular schwannoma
    Abraham Jacob; Fiscal Year: 2013
    ..blots), we plan to better understand the end biologic effects of decreased AKT signaling on apoptosis and cell cycle regulation in VS...
    Zbigniew Darzynkiewicz; Fiscal Year: 2013
    ..types of DNA damage will be assessed including that caused by drugs, mutagens and radiation, and correlated with cell cycle phase and induction of apoptosis...
  50. Inactivation of Hdac3 in the cause, prevention, and treatment of HCC
    Scott W Hiebert; Fiscal Year: 2013
    ..Because of these key roles in cell cycle control, HDACs have become an important target for therapeutic intervention in a variety of tumors and the first ..
  51. Transplantation of Reduced-Size Fatty Livers
    Zhi Zhong; Fiscal Year: 2010
    ..Cell proliferation and factors regulating regeneration (cytokines, transcription factors, growth factors, and cell cycle related genes) will be evaluated...
  52. Using Mass Spectroscopy to Characterize Transcription Proteins and F2-Isoprostane
    BETTYE HENNINTON; Fiscal Year: 2011
    ..regulated and timed reversible phosphorylation is used to activate or inhibit pathway proteins throughout the cell cycle. Common intracellular signal transduction events occur with up to one third of all proteins at any one point in ..
  53. Chromosomal Control of Segregation of C. Elegans
    Abby F Dernburg; Fiscal Year: 2013
    ..of meiosis have yielded insights into fundamental cell processes, including DNA repair, chromosome dynamics, and cell cycle regulation...
  54. Novel genetics, pathobiology &therapy of nephronophthisis-related ciliopathies
    Friedhelm Hildebrandt; Fiscal Year: 2013
    ..By identification of the NPHP1-9 genes we implicated non-canonical Wnt signaling, hedgehog signaling, and cell cycle regulation in the pathogenesis of cystic kidney diseases...
  55. ECM compliance and cell cycle control
    RICHARD ASSOIAN; Fiscal Year: 2012
    ..The necessity of integrin signaling for G1 phase cell cycle progression is now well established, but the approaches that have been used to document ECM/integrin effects ..
  56. The Role of PKR in a Novel IL-3 Signal Transduction Pathway
    William Stratford May; Fiscal Year: 2012
    ..Removal of IL-3 from factor- dependent cells induces cell cycle arrest and apoptosis...
  57. Evaluation of novel FoxM1 inhibitors against liver cancer
    Andrei L Gartel; Fiscal Year: 2012
    ..FoxM1 is a transcription factor that regulates the expression of a number of genes that are involved in cell cycle regulation...
  58. Metnase, PIKK, and RPA Roles in DNA Damage and Replication Stress Responses
    Jac A Nickoloff; Fiscal Year: 2013
    ..Normal and tumor cells respond to DNA damage and associated replication stress by activating DNA repair, cell cycle arrest (checkpoint) systems, and when damage is severe, programmed death pathways, collectively termed the DNA ..
  59. Regulation of KSHV Latency
    Paul M Lieberman; Fiscal Year: 2013
    ..g. SMC1, SMC3, Rad21). In addition, changes in CTCF-cohesin interactions contribute to the cell cycle activation of vGPCR in latently infected PEL cells...
  60. Tea Polyphenols in Chemoprevention of Prostate Cancer
    ..of insulin-like growth factor (IGF-1) leading to the inhibition of proliferation, induction of apoptosis, cell cycle arrest as well as inhibition of angiogenesis...
  61. New pathways regulating bile acid homeostasis and cholestatic liver diseases
    Li Wang; Fiscal Year: 2013
    ..Previously E2F1 has been shown to play a role in cell cycle progression, apoptosis, and adipocyte and beta cell function...
  62. Roles of the mammalian CST complex in DNA replication and chromosome cohesion
    JASON AARON STEWART; Fiscal Year: 2013
    ..repair, the cell has evolved mechanisms to prevent these impediments from causing a DNA damage response and cell cycle arrest. However, how this occurs remains poorly understood...
  63. Derivation of cerebral cortical GABAergic interneurons from human iPS cells
    Lorenz P Studer; Fiscal Year: 2010
    ..in mitotic interneuron progenitors, whereas Lhx6 is expressed by the some of the same progenitors at the time of cell cycle exit and maintained during subsequent development...
  64. Organismal Radioprotection Through Pharmacological Quiescence
    JOHN S CHANT; Fiscal Year: 2010
    ..HSPC) through the inhibition of cyclin dependent kinases (CDK's) which govern the G1-S transition of the cell cycle. As quiescent cells are resistant to IR, PQ enhances the per cell survival of HSPC by augmenting the repair of ..
    Stuart Ravnik; Fiscal Year: 2002
    DESCRIPTION: The overall objective of this research is to understand how cell cycle regulatory molecules function to control the meiotic cell divisions in germ cells...
  66. Molecular Determinants Affecting FLT-PET in Colorectal Cancer
    HENRY C MANNING; Fiscal Year: 2010
    ..serves as a surrogate marker of proliferation by reporting the activity of thymidine salvage, a complex cell cycle-driven mechanism that sequesters deoxyribonucleosides from the extracellular environment to provide dividing ..
  67. Role of Tumor and Stromal Cell Metabolism in Stress Adaptation and Progression
    EILEEN contact WHITE; Fiscal Year: 2010
    ..Possible responses include cell death (apoptosis or necrosis), cell cycle exit (quiescence or senescence) or adaptation and survival (autophagy)...
  68. Chemical dissection of phospho-signaling that controls the caulobacter cell cycle
    The goal of this work is to understand the molecular mechanisms driving the cell cycle of the bacterium Caulobacter crescentus...
    PATRICIA PREISIG; Fiscal Year: 2004
    ..two mechanisms of renal epithelial cell hypertrophy have been characterized; One involves regulation of the cell cycle process (referred to as being cell cycle-dependent) and is mediated by growth factors and cytokines, and the ..
  70. Automated analysis of cell cycle genes in Trypanosoma brucei
    LAWRENCE RUBEN; Fiscal Year: 2009
    ..Although the cell cycle is generally conserved, trypanosomes have unique features that prevent identification of many regulatory ..