Genomes and Genes
Summary: Any of several ways in which living cells of an organism communicate with one another, whether by direct contact between cells or by means of chemical signals carried by neurotransmitter substances, hormones, and cyclic AMP.
Publications318 found, 100 shown here
- Membrane vesicles as conveyors of immune responsesClotilde Thery
Institut National de la Santé et de la Recherche Médicale U932, Institut Curie, 26 Rue d Ulm, Paris, 75005, France
Nat Rev Immunol 9:581-93. 2009..This Review focuses on the role of membrane vesicles, in particular exosomes, in the communication between immune cells, and between tumour and immune cells...
- Quorum sensing: cell-to-cell communication in bacteriaChristopher M Waters
Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544 1014, USA
Annu Rev Cell Dev Biol 21:319-46. 2005..how chemical information is integrated, processed, and transduced to control gene expression; how intra- and interspecies cell-cell communication is accomplished; and the intriguing possibility of prokaryote-eukaryote cross-communication.
- Exosomes/microvesicles as a mechanism of cell-to-cell communicationGiovanni Camussi
Department of Internal Medicine, Centre for Molecular Biotechnology and Centre for Research in Experimental Medicine, Torino, Italy
Kidney Int 78:838-48. 2010..An increasing body of evidence indicates that they play a pivotal role in cell-to-cell communication. Indeed, they may directly stimulate target cells by receptor-mediated interactions or may transfer from the ..
- Exosomes--vesicular carriers for intercellular communicationMikael Simons
Max Planck Institute for Experimental Medicine, Gottingen, Germany
Curr Opin Cell Biol 21:575-81. 2009..Only recently light have been shed on the subcellular compartments and mechanisms involved in their biogenesis and secretion opening new avenues to understand their functions...
- Microvesicles: mediators of extracellular communication during cancer progressionVandhana Muralidharan-Chari
Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556 0369, USA
J Cell Sci 123:1603-11. 2010..This Commentary summarizes recent literature on the properties and biogenesis of microvesicles and their potential role in cancer progression...
- Astrocytes, from brain glue to communication elements: the revolution continuesAndrea Volterra
Department of Cell Biology and Morphology, University of Lausanne, Rue du Bugnon 9, 1005 Lausanne, Switzerland
Nat Rev Neurosci 6:626-40. 2005..Examples of their specific and essential roles in normal physiological processes have begun to accumulate, and the number of diseases known to involve defective astrocytes is increasing...
- Cell-cell communication between malaria-infected red blood cells via exosome-like vesiclesNeta Regev-Rudzki
Division of Infection and Immunity, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
Cell 153:1120-33. 2013Cell-cell communication is an important mechanism for information exchange promoting cell survival for the control of features such as population density and differentiation...
- Contact inhibition of locomotion in vivo controls neural crest directional migrationCarlos Carmona-Fontaine
Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, UK
Nature 456:957-61. 2008..These results provide the first example of contact inhibition of locomotion in vivo, provide an explanation for coherent directional migration of groups of cells and establish a previously unknown role for non-canonical Wnt signalling...
- Prions hijack tunnelling nanotubes for intercellular spreadKarine Gousset
Unité de Trafic Membranaire et Pathogénèse, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
Nat Cell Biol 11:328-36. 2009..been identified between cells, both in vitro and in vivo, and may represent a conserved means of cell-to-cell communication. Here we show that TNTs allow transfer of exogenous and endogenous PrP(Sc) between infected and naive ..
- Collective chemotaxis requires contact-dependent cell polarityEric Theveneau
Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK
Dev Cell 19:39-53. 2010....
- Exosomes: a common pathway for a specialized functionGuillaume van Niel
Institut Curie, CNRS UMR144, 75248 Paris Cedex, France
J Biochem 140:13-21. 2006..These findings open up new therapeutic and diagnostic strategies...
- Cell contact, prostaglandin E(2) and transforming growth factor beta 1 play non-redundant roles in human mesenchymal stem cell induction of CD4+CD25(High) forkhead box P3+ regulatory T cellsK English
Institute of Immunology, National University of Ireland Maynooth, Maynooth, Co Kildare, Ireland
Clin Exp Immunol 156:149-60. 2009..Overall, this study provides a rational basis for ongoing clinical studies involving allogeneic MSC...
- Exosomal-like vesicles are present in human blood plasmaMarie Pierre Caby
Institut National de la Sante et de la Recherche Medicale, Unité 520, Institut Curie, 12 rue Lhomond, 75005 Paris, France
Int Immunol 17:879-87. 2005..Our results demonstrate that blood is a physiological fluid for exosome circulation in the body, suggesting their role in cell-cell or organ-organ communications as carriers for molecules that need to reach distant cell targets...
- Membrane-derived microvesicles: important and underappreciated mediators of cell-to-cell communicationJ Ratajczak
The Stem Cell Biology Program, James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
Leukemia 20:1487-95. 2006....
- Network biology: understanding the cell's functional organizationAlbert Laszlo Barabasi
Department of Physics, University of Notre Dame, Notre Dame, Indiana 46556, USA
Nat Rev Genet 5:101-13. 2004
- The transcellular spread of cytosolic amyloids, prions, and prionoidsAdriano Aguzzi
Institute of Neuropathology, University Hospital of Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
Neuron 64:783-90. 2009....
- The immunological synapse of CTL contains a secretory domain and membrane bridgesJ C Stinchcombe
Sir William Dunn School of Pathology, South Parks Road, Oxford, OX1 3RE, United Kingdom
Immunity 15:751-61. 2001..Electron microscopy reveals continuities forming membrane bridges between the CTL and target cell membranes, suggesting a possible mechanism for this transfer...
- Exosomes: new players in cell-cell communicationClaudia Bang
Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Hannover, Germany
Int J Biochem Cell Biol 44:2060-4. 2012..discovery that exosomes contain proteins, messenger and microRNAs suggests a role as mediators in cell-to-cell communication. Exosomes can be transported between different cells and influence physiological pathways in the recipient ..
- Rab27a and Rab27b control different steps of the exosome secretion pathwayMatias Ostrowski
INSERM U932, 26 Rue d Ulm, 75005 Paris, France
Nat Cell Biol 12:19-30; sup pp 1-13. 2010..Our results therefore strengthen the link between MVEs and exosomes, and introduce ways of manipulating exosome secretion in vivo...
- Keratinocyte-fibroblast interactions in wound healingSabine Werner
Institute of Cell Biology, Eidgenossische Technische Hochschule Zurich, Honggerberg, Zurich, Switzerland
J Invest Dermatol 127:998-1008. 2007..As the phenotype of fibroblasts from different tissues or body sites becomes better defined, we may understand their individual contribution in wound healing in more detail and possibly explain different clinical outcomes...
- Regulation of gene expression by cell-to-cell communication: acyl-homoserine lactone quorum sensingC Fuqua
Department of Biology, Indiana University, Bloomington, Indiana 47405, USA
Annu Rev Genet 35:439-68. 2001..Recent studies have begun to integrate acyl-HSL quorum sensing into global regulatory networks and establish its role in developing and maintaining the structure of bacterial communities...
- Molecular mechanisms regulating hair follicle developmentSarah E Millar
Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
J Invest Dermatol 118:216-25. 2002..The purpose of this review is to summarize recent progress in our understanding of the molecular mechanisms regulating hair follicle formation, and to discuss ways in which this information may eventually be utilized in the clinic...
- Gap junctions and the connexin protein familyGoran Sohl
Institut fur Genetik, Abteilung Molekulargenetik, Universitat Bonn, 53117 Bonn, Germany
Cardiovasc Res 62:228-32. 2004..As yet only little is known about mutations in the human genes for Cx37, Cx40, Cx43 and Cx45. Thus, a profound comparison between human and mouse phenotypes is not yet possible...
- Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor betaK Nakamura
Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 194:629-44. 2001..This, plus the fact that we could find no evidence that a soluble factor mediates suppression, strongly suggests that CD4(+)CD25(+) T cells exert immunosuppression by a cell-cell interaction involving cell surface TGF-beta1...
- Transfer of microRNAs by embryonic stem cell microvesiclesAlex Yuan
Jules Stein Eye Institute, UCLA School of Medicine, Los Angeles, California, United States of America
PLoS ONE 4:e4722. 2009..Embryonic stem cell microvesicles may be useful therapeutic tools for transferring mRNA, microRNAs, protein, and siRNA to cells and may be important mediators of signaling within stem cell niches...
- Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivoAmelia Bartholomew
University of Illinois, Chicago 60607, USA
Exp Hematol 30:42-8. 2002..We hypothesized that the activities of MSCs in the bone marrow microenvironment might also include immunomodulatory effects on lymphocytes...
- Functional connectivity between immune cells mediated by tunneling nanotubulesSimon C Watkins
Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Immunity 23:309-18. 2005..These results demonstrate that nonneuronal cells can transmit signals to distant cells through a physically connected network...
- New mechanism for Notch signaling to endothelium at a distance by Delta-like 4 incorporation into exosomesHelen Sheldon
Cancer Research UK Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
Blood 116:2385-94. 2010..This reversal in phenotype appears to enhance vessel formation and is a new form of signaling for Notch ligands that expands their signaling potential beyond cell-cell contact...
- Intercellular (mis)communication in neurodegenerative diseaseGwenn A Garden
Department of Neurology, University of Washington, Seattle, WA 98195, USA
Neuron 73:886-901. 2012..Here, we review findings highlighting the importance of pathological cell-cell communication in neurodegenerative disease...
- Myeloid microvesicles are a marker and therapeutic target for neuroinflammationClaudia Verderio
Italian National Research Council Institute of Neuroscience and Department of Medical Pharmacology, University of Milan, Milan, Italy
Ann Neurol 72:610-24. 2012..The aim of the study was to evaluate whether MVs are released by microglia/macrophages in vivo and whether their number varies in brain inflammatory conditions, such as multiple sclerosis (MS)...
- Small talk. Cell-to-cell communication in bacteriaBonnie L Bassler
Department of Molecular Biology, Princeton University, NJ 08544, USA
Cell 109:421-4. 2002..A diverse array of secreted chemical signal molecules and signal detection apparatuses facilitate highly productive intra- and interspecies relationships...
- Local Ca2+ detection and modulation of synaptic release by astrocytesMaria Amalia Di Castro
Department of Cell Biology and Morphology, University of Lausanne, Lausanne, Switzerland
Nat Neurosci 14:1276-84. 2011..These data provide direct evidence that astrocytes are integrated in local synaptic functioning in adult brain...
- The effects of connexin phosphorylation on gap junctional communicationPaul D Lampe
Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North DE 320, Box 19024, Seattle, WA 98109, USA
Int J Biochem Cell Biol 36:1171-86. 2004..In several cases, use of site-directed mutants of these sites have shown that these specific phosphorylation events can be linked to changes in gap junctional communication...
- Tube morphogenesis: making and shaping biological tubesBarry Lubarsky
Howard Hughes Medical Institute, Department of Biochemistry, Stanford University, School of Medicine, Stanford, CA 94305, USA
Cell 112:19-28. 2003..We propose a unifying mechanism of tube morphogenesis that has been modified to create tube diversity and describe how defects in the tube size-sensing step can lead to polycystic kidney disease...
- Radiation-induced bystander signalling in cancer therapyKevin M Prise
Centre for Cancer Research and Cell Biology, Queen s University Belfast, Belfast, UK
Nat Rev Cancer 9:351-60. 2009..This Review outlines the key aspects of radiation-induced intercellular signalling and assesses its relevance for existing and future radiation-based therapies...
- Cysteine-rich peptides (CRPs) mediate diverse aspects of cell-cell communication in plant reproduction and developmentEleanor Marshall
School of Life Sciences, University of Warwick, Wellesbourne Campus, Wellesbourne, UK
J Exp Bot 62:1677-86. 2011Cell-cell communication in plants is essential for the correct co-ordination of reproduction, growth, and development...
- Functional microRNA is transferred between glioma cellsMark Katakowski
Department of Neurology, Henry Ford Hospital, Detroit, Michigan 48202, USA
Cancer Res 70:8259-63. 2010..These findings reveal a novel mechanism of targeted intercellular protein regulation between brain tumor cells...
- The brain tumor microenvironmentNikki A Charles
Departments of Surgery Neurosurgery, Neurology, and Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, USA
Glia 59:1169-80. 2011..cell populations and highlight the pathological impact and signaling pathways known for these types of cell-cell communication. The tumor-vasculature not only nourishes glioblastomas, but also provides a specialized niche for these ..
- Intercellular communication by exchange of cytoplasmic material via tunneling nano-tube like structures in primary human renal epithelial cellsSophie Domhan
Department of Medicine, Center of Cancer Systems Biology, St Elizabeth s Medical Center, Tufts University, Boston, Massachusetts, United States of America
PLoS ONE 6:e21283. 2011..Our data indicates an unexpected dynamic of intercellular communication between RPTEC by exchange of cytosolic material, which may play an important role in renal physiology...
- Pyramidal cell communication within local networks in layer 2/3 of rat neocortexCarl Holmgren
Karolinska Institute, Department of Neuroscience, Retzius vag 8, B2 2, S 17177 Stockholm, Sweden
J Physiol 551:139-53. 2003..We suggest that computation in the local network may proceed not only by direct pyramidal-pyramidal cell communication but also via local interneurons...
- New insights into neuron-glia communicationR Douglas Fields
Neurocytology and Physiology Section, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
Science 298:556-62. 2002..By releasing neurotransmitters and other extracellular signaling molecules, glia can affect neuronal excitability and synaptic transmission and perhaps coordinate activity across networks of neurons...
- The cadherin superfamily in neuronal connections and interactionsMasatoshi Takeichi
RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe 650 0047, Japan
Nat Rev Neurosci 8:11-20. 2007..In this review I discuss the roles of three subfamilies - classic cadherins, Flamingo/CELSRs and protocadherins - in the regulation of neuronal recognition and connectivity...
- Mesenchymal stem cells inhibit human Th17 cell differentiation and function and induce a T regulatory cell phenotypeSoufiane Ghannam
Institut National de la Sante et de la Recherche Medicale, Unité 844, Hopital St Eloi, Universite Montpellier I, France
J Immunol 185:302-12. 2010..These results showed that, under inflammatory conditions, MSCs mediate the adhesion of Th17 cells via CCR6 and exert anti-inflammatory effects through the induction of a T cell regulatory phenotype in these cells...
- Reciprocal activating interaction between natural killer cells and dendritic cellsFranca Gerosa
Department of Pathology, Section of Immunology, University of Verona, 37100 Verona, Italy
J Exp Med 195:327-33. 2002..These data demonstrated for the first time a bidirectional cross talk between NK cells and DC, in which NK cells activated by IL-2 or by mature DC induce DC maturation...
- Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cellsHadi Valadi
Department of Internal Medicine, The Sahlgrenska Academy, Goteborg University, Sweden
Nat Cell Biol 9:654-9. 2007..In summary, we show that exosomes contain both mRNA and microRNA, which can be delivered to another cell, and can be functional in this new location. We propose that this RNA is called "exosomal shuttle RNA" (esRNA)...
- Stromal effects on mammary gland development and breast cancerBryony S Wiseman
Department of Anatomy, University of California, 513 Parnassus Avenue, San Francisco, CA 94143, USA
Science 296:1046-9. 2002..To find cures for diseases like breast cancer that rely on epithelial-stromal crosstalk, we must understand how these different cell types communicate with each other...
- Microvesicle entry into marrow cells mediates tissue-specific changes in mRNA by direct delivery of mRNA and induction of transcriptionJason M Aliotta
Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Division of Hematology and Oncology, Providence, RI 02903, USA
Exp Hematol 38:233-45. 2010..The present studies establish that entry of lung-derived microvesicles into marrow cells is a prerequisite for marrow expression of pulmonary epithelial cell-derived mRNA...
- Friends or foes - bipolar effects of the tumour stroma in cancerMargareta M Mueller
Group Tumor and Microenvironment, German Cancer Research Centre, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
Nat Rev Cancer 4:839-49. 2004..What have we recently learned from studying tumour-stroma interactions, and will this help to define new targets for therapy?..
- Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein deliveryJ Ratajczak
Stem Cell Biology Program, James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
Leukemia 20:847-56. 2006..We postulate that ES-MV may efficiently expand HPC by stimulating them with ES-MV expressed ligands (e.g., Wnt-3) as well as increase their pluripotency after horizontal transfer of ES-derived mRNA...
- Gap junctions and connexin-interacting proteinsBen N G Giepmans
Department of Neurosciences, The National Center of Microscopy and Imaging Research, University of California San Diego, School of Medicine, 1000 BSB, 9500 Gilman Drive, MC0608, La Jolla, CA 92093 0608, USA
Cardiovasc Res 62:233-45. 2004..The striking similarity of proteins present at the cytoplasmic face of tight junctions, adherens junctions and gap junctions and their possible role in gene transcription and cytoskeletal anchorage is highlighted...
- Expression of Pseudomonas aeruginosa virulence genes requires cell-to-cell communicationL Passador
Department of Microbiology and Immunology, University of Rochester, School of Medicine and Dentistry, NY 14620
Science 260:1127-30. 1993..PAI provides P. aeruginosa with a means of cell-to-cell communication that is required for the expression of virulence genes and may provide a target for therapeutic approaches.
- Molecular regulation of lumen morphogenesisAnirban Datta
Department of Anatomy, University of California San Francisco, CA 94143 2140, USA
Curr Biol 21:R126-36. 2011..We here discuss progress in understanding common design principles underpinning de novo lumen formation and expansion...
- EPLIN mediates linkage of the cadherin catenin complex to F-actin and stabilizes the circumferential actin beltKentaro Abe
RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe 650 0047, Japan
Proc Natl Acad Sci U S A 105:13-9. 2008....
- Tunnelling nanotubes: a highway for prion spreading?Karine Gousset
Institut Pasteur, Unité de Trafic Membranaire et Pathogénèse, Paris, France
Prion 3:94-8. 2009..Therefore, we propose a role for TNTs during prion spreading from the periphery to the central nervous system (CNS). Here, we discuss some of the key steps where TNTs might play a role during prion neuroinvasion...
- Tunneling-nanotube development in astrocytes depends on p53 activationY Wang
Laboratory of Neurobiology and State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, Peking University, Beijing, China
Cell Death Differ 18:732-42. 2011..Akt, phosphoinositide 3-kinase and mTOR are involved in TNT induction. Our data suggest that TNTs might be a mechanism for cells to respond to harmful signals and transfer cellular substances or energy to another cell under stress...
- Tumor-stroma interactions in pancreatic ductal adenocarcinomaDaruka Mahadevan
Hematology Oncology, The University of Arizona Cancer Center, 1515 North Campbell Avenue, Tucson, AZ 58724, USA
Mol Cancer Ther 6:1186-97. 2007..This review summarizes our current understanding of the mechanisms that potentially drive the DR in PDA and future possibilities for therapeutic targeting of this critical process...
- Lymph node fibroblastic reticular cells construct the stromal reticulum via contact with lymphocytesTomoya Katakai
Center for Molecular Biology and Genetics, Kyoto University, 53 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
J Exp Med 200:783-95. 2004..These findings suggest that signals from lymphocytes induce FRCs to form the network that supports the movement and interactions of immune effectors within the lymph node...
- Cutting edge: contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanismDavid C Gondek
Department of Microbiology and Immunology, Dartmouth Medical School and Norris Cotton Cancer Center, Lebanon, NH 03756, USA
J Immunol 174:1783-6. 2005..In summary, GZ-B is one of the key mechanisms through which CD4+CD25+ Treg induce cell contact-mediated suppression...
- Exosomes: vesicular carriers for intercellular communication in neurodegenerative disordersAnja Schneider
Department of Psychiatry and Psychotherapy, University Medicine Goettingen, Von Siebold Str 5, 37075, Goettingen, Germany
Cell Tissue Res 352:33-47. 2013..In this review, we focus on the cell biology and function of neuronal microvesicles/exosomes and discuss the evidence for pathogenic intercellular protein transfer mediated by vesicular carriers...
- Mycobacterium tuberculosis-induced neutrophil ectosomes decrease macrophage activationTonya Azevedo Duarte
Health Science Institute, Federal University of Bahia, Salvador, BA, Brazil
Tuberculosis (Edinb) 92:218-25. 2012..We found that the ectosomes derived from infected neutrophils are biologically active and can influence the survival of Mycobacterium tuberculosis within macrophages...
- Rab11 regulates cell-cell communication during collective cell movementsDamien Ramel
Institute for Research in Immunology and Cancer IRIC and Department of Pathology and Cell Biology, Faculty of Medicine, Universite de Montreal, Montreal, Quebec, H3C 3J7, Canada
Nat Cell Biol 15:317-24. 2013..group to ensure that Rac activity is properly restricted to the leading cell through regulation of cell-cell communication. In addition, we show that Rab11 binds to the actin cytoskeleton regulator Moesin and regulates its ..
- The Hippo pathway and apico-basal cell polarityAlice Genevet
Apoptosis and Proliferation Control Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3LY, UK
Biochem J 436:213-24. 2011..We focus on the regulation of Yki/YAP by apical proteins, but also on how the Hpo pathway might in turn influence apical domain size as part of a regulatory feedback loop...
- Natural killer cells and dendritic cells: rendezvous in abused tissuesAlessandro Moretta
Dipartimento di Medicina Sperimentale, Sezione di Istologia, and Centro di Eccellenza per le Ricerche Biomediche, Universita degli Studi di Genova, 16132 Genova, Italy
Nat Rev Immunol 2:957-64. 2002....
- Exosomes: immune properties and potential clinical implementationsNathalie Chaput
Institut National de la Santé et de la Recherche Médicale U1015, Villejuif, 94805, France
Semin Immunopathol 33:419-40. 2011....
- Mechanisms of axon ensheathment and myelin growthDiane L Sherman
Centre for Neuroscience Research, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, UK
Nat Rev Neurosci 6:683-90. 2005....
- TGFβ modulates cell-to-cell communication in early epithelial-to-mesenchymal transitionC E Hills
School of Life Sciences, University of Warwick, Coventry CV4 7AL, UK
Diabetologia 55:812-24. 2012..Here we investigated whether TGF-β1-induced epithelial-to-mesenchymal transition (EMT) plays a role in alterations in cell adhesion, cell coupling and cell communication in the human renal proximal tubule.
- Glioblastoma-induced attraction of endogenous neural precursor cells is associated with improved survivalRainer Glass
Cellular Neuroscience Group, Max Delbruck Center for Molecular Medicine, 13092 Berlin, Germany
J Neurosci 25:2637-46. 2005..Our results indicate that tumor cells attract endogenous precursor cells; the presence of precursor cells is antitumorigenic; and this cellular interaction decreases with aging...
- A bacterial cell-cell communication signal with cross-kingdom structural analoguesLian Hui Wang
Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609
Mol Microbiol 51:903-12. 2004Extracellular signals are the key components of microbial cell-cell communication systems. This report identified a diffusible signal factor (DSF), which regulates virulence in Xanthomonas campestris pv...
- Macrophage- and dendritic cell--dependent regulation of human B-cell proliferation requires the TNF family ligand BAFFAndrew Craxton
Department of Microbiology, University of Washington, Seattle, WA 98195, USA
Blood 101:4464-71. 2003....
- Reprogramming metastatic tumour cells with embryonic microenvironmentsMary J C Hendrix
Cancer Biology and Epigenomics Program, Children s Memorial Research Centre, Robert H Lurie Comprehensive Cancer Centre, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60614, USA
Nat Rev Cancer 7:246-55. 2007..This Review will summarize the embryonic models used to reverse the metastatic melanoma phenotype, and highlight the prominent signalling pathways that have emerged as noteworthy targets for future consideration...
- Astrocytic modulation of sleep homeostasis and cognitive consequences of sleep lossMichael M Halassa
Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Neuron 61:213-9. 2009....
- EphA-Ephrin-A-mediated beta cell communication regulates insulin secretion from pancreatic isletsIrena Konstantinova
Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany
Cell 129:359-70. 2007..We further show that EphA-ephrin-A-mediated beta cell communication is bidirectional: EphA forward signaling inhibits insulin secretion, whereas ephrin-A reverse signaling ..
- Interaction of human mesenchymal stem cells with cells involved in alloantigen-specific immune response favors the differentiation of CD4+ T-cell subsets expressing a regulatory/suppressive phenotypeRita Maccario
Laboratorio di Immunologia dei Trapianti, Oncoematologia Pediatrica, IRCCS Policlinico San Matteo, P le Golgi 19, 27100 Pavia, Italy
Haematologica 90:516-25. 2005..We extended the evaluation of mechanisms responsible for the immune regulatory effect derived from the interaction of human MSC with cells involved in alloantigen-specific immune response in mixed lymphocyte culture (MLC)...
- Nanotubular highways for intercellular organelle transportAmin Rustom
Interdisciplinary Center of Neuroscience IZN, Institute of Neurobiology, University of Heidelberg, INF 364, Heidelberg 69120, Germany
Science 303:1007-10. 2004Cell-to-cell communication is a crucial prerequisite for the development and maintenance of multicellular organisms...
- Intercellular communication in the mammalian ovary: oocytes carry the conversationMartin M Matzuk
Department of Pathology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA
Science 296:2178-80. 2002..The challenge for the future is to identify the factors that participate in this communication and their mechanisms of action...
- Socializing with the neighbors: stem cells and their nicheElaine Fuchs
Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
Cell 116:769-78. 2004..In this review, we examine adult stem cell niches and their impact on stem cell biology...
- Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responsesT B Geijtenbeek
Department of Tumor Immunology, University Medical Center St Radboud, Nijmegen, The Netherlands
Cell 100:575-85. 2000..Since antibodies against DC-SIGN inhibit DC-induced proliferation of resting T cells, our findings predict that DC-SIGN enables T cell receptor engagement by stabilization of the DC-T cell contact zone...
- Finding the right niche: B-cell migration in the early phases of T-dependent antibody responsesJoão Pedro Pereira
Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, 94143, USA
Int Immunol 22:413-9. 2010..In this review, we discuss current understanding of the roles played by chemokines, S1P and EBI2 in the migration events that underlie humoral immune responses...
- Cell-cell communication in carcinogenesisJ E Trosko
Department of Pediatrics and Human Development, Michigan State University, East Lansing, Michigan 48824, USA
Front Biosci 3:d208-36. 1998..Normal homeostatic control of these three forms of cell communication determines whether: (a) the cell remains quiescent (Go); (b) enters into the cell proliferation phase; (c) ..
- Tunneling nanotubes: a new route for the exchange of components between animal cellsHans Hermann Gerdes
Department of Biomedicine, University of Bergen, Jonas Lies vei 91, Bergen 5009, Norway
FEBS Lett 581:2194-201. 2007..It has been proposed that TNTs represent a novel and general biological principle of cell-to-cell communication and it becomes increasingly apparent that they fulfill important functions in the physiological processes of ..
- Animal cells connected by nanotubes can be electrically coupled through interposed gap-junction channelsXiang Wang
Department of Biomedicine, University of Bergen, 5009 Bergen, Norway
Proc Natl Acad Sci U S A 107:17194-9. 2010Tunneling nanotubes (TNTs) are recently discovered conduits for a previously unrecognized form of cell-to-cell communication. These nanoscale, F-actin-containing membrane tubes connect cells over long distances and facilitate the ..
- The microenvironment of the tumour-host interfaceL A Liotta
Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
Nature 411:375-9. 2001..A new class of cancer therapies that targets this pathological communication interface between tumour cells and host cells is currently under development...
- Neuronal somatic ATP release triggers neuron-satellite glial cell communication in dorsal root gangliaX Zhang
Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX 77555 1069, USA
Proc Natl Acad Sci U S A 104:9864-9. 2007..the nucleus, is mainly responsible for synthesis of macromolecules and has a limited role in cell-to-cell communication. Using sniffer patch recordings, we show here that electrical stimulation of dorsal root ganglion (DRG) ..
- SAP-controlled T-B cell interactions underlie germinal centre formationHai Qi
Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nature 455:764-9. 2008..These results offer an explanation for the germinal centre defect due to SAP deficiency and provide new insights into the bi-directional communication between cognate T and B cells in vivo...
- Dendritic cells interact directly with naive B lymphocytes to transfer antigen and initiate class switching in a primary T-dependent responseM Wykes
Sir William Dunn School of Pathology, University of Oxford, United Kingdom
J Immunol 161:1313-9. 1998..Taken together, these observations show that DC have an important role in the initiation of Ab synthesis by direct interaction with B cells...
- Structure and mechanism of cadherins and catenins in cell-cell contactsSabine Pokutta
Department of Structural Biology and Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
Annu Rev Cell Dev Biol 23:237-61. 2007....
- Osteoclast-osteoblast communicationKoichi Matsuo
Department of Microbiology and Immunology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, 160 8582 Tokyo, Japan
Arch Biochem Biophys 473:201-9. 2008..At the termination phase, bone remodeling is completed by osteoblastic bone formation and mineralization of bone matrix. Here, we describe molecular communication between osteoclasts and osteoblasts at distinct phases of bone remodeling...
- Different types of cell-to-cell connections mediated by nanotubular structuresPeter Veranic
Institute of Cell Biology, Faculty of Medicine, University of Ljubljana, SI 1000 Ljubljana, Slovenia
Biophys J 95:4416-25. 2008..A possible model of formation and mechanical stability of nanotubes that bridge two neighboring cells is discussed...
- Circadian gene expression in individual fibroblasts: cell-autonomous and self-sustained oscillators pass time to daughter cellsEmi Nagoshi
Department of Molecular Biology and NCCR Frontiers in Genetics, Sciences III, University of Geneva, 30, Quai Ernest Ansermet, CH 1211 Geneva 4, Switzerland
Cell 119:693-705. 2004..Specifically, the circadian oscillator gates cytokinesis to defined time windows, and mitosis elicits phase shifts in circadian cycles...
- Activated T cells recruit exosomes secreted by dendritic cells via LFA-1Esther N M Nolte-'t Hoen
Faculty of Veterinary Medicine, Department of Biochemistry and Cell Biology, Utrecht University, Utrecht, The Netherlands
Blood 113:1977-81. 2009..These results imply that DC exosomes secreted in the extracellular milieu during cognate T-cell-DC interactions are targeted to T cells activated in that microenvironment...
- Hijacking the T-cell communication network by the human T-cell leukemia/lymphoma virus type 1 (HTLV-1) p12 and p8 proteinsNancy Van Prooyen
Animal Models and Retroviral Vaccine Section, Vaccine Branch, National Cancer Institute, National Institute of Health, Bethesda, MD 20892 5065, USA
Mol Aspects Med 31:333-43. 2010..Altogether the current knowledge demonstrates that the concerted activity of p8 and p12 is essential for the persistence of virus infected cells in the host...
- Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6Gaetan Jego
Baylor Institute for Immunology Research, 3434 Live Oak Street, Dallas, Texas 75204, USA
Immunity 19:225-34. 2003..These plasma cells display the high levels of CD38 found on tissue plasma cells. Thus, pDCs are critical for the generation of plasma cells and antibody responses...
- Human basophils and eosinophils are the direct target leukocytes of the novel IL-1 family member IL-33Tatjana Pecaric-Petkovic
Institute of Immunology, University Hospital Bern, Inselspital, Bern, Switzerland
Blood 113:1526-34. 2009....
- CD8+ dendritic cells use LFA-1 to capture MHC-peptide complexes from exosomes in vivoElodie Segura
Centre de Recherche, Institut Curie, Paris, France
J Immunol 179:1489-96. 2007..We propose a new role for LFA-1 on DCs, as a receptor for exosomes to favor Ag transfer between DCs in vivo...
- Membrane nanotubes: dynamic long-distance connections between animal cellsDaniel M Davis
Division of Cell and Molecular Biology, Sir Alexander Fleming Building, Imperial College, London, SW7 2AZ, UK
Nat Rev Mol Cell Biol 9:431-6. 2008..Despite recent progress in this young research field, further research is sorely needed...
- Gap junctions and the propagation of cell survival and cell death signalsD V Krysko
Department of Human Anatomy, Embryology, Histology and Medical Physics, Ghent University, 9000 Ghent, Belgium
Apoptosis 10:459-69. 2005..Finally, direct signal transduction activity of connexins in cell death and survival pathways is addressed...
- Connexins and their channels in cell growth and cell deathMathieu Vinken
Department of Toxicology, Vrije Universiteit Brussel VUB, Laarbeeklaan 103, B 1090 Brussels, Belgium
Cell Signal 18:592-600. 2006..We also briefly discuss the role of gap junctional intercellular communication in carcinogenesis and the potential use of connexins as tools for cancer therapy...
- The art of cellular communication: tunneling nanotubes bridge the divideSteffen Gurke
Department of Biomedicine, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway
Histochem Cell Biol 129:539-50. 2008..Recently, a new type of cell-to-cell communication was discovered, based on de novo formation of membranous nanotubes between cells...
- Upregulation of the viability of nucleus pulposus cells by bone marrow-derived stromal cells: significance of direct cell-to-cell contact in coculture systemYukihiro Yamamoto
Department of Orthopaedic Surgery, Tokai University School of Medicine, Kanagawa, Japan
Spine (Phila Pa 1976) 29:1508-14. 2004..Upregulation of the viability of nucleus pulposus cells by coculture with bone marrow-derived stromal cells using a novel culture system...
- N-cadherin-mediated intercellular interactions promote survival and migration of melanoma cellsG Li
The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
Cancer Res 61:3819-25. 2001....
- Intercellular transfer mediated by tunneling nanotubesHans Hermann Gerdes
Department of Biomedicine, University of Bergen, Jonas Lies vei 91, Bergen 5009, Norway
Curr Opin Cell Biol 20:470-5. 2008..In 2004, a new route of cell-to-cell communication mediated by tunneling nanotubes (TNT) was reported...
- "The 1st International Conference on Osteoimmunology: Interactions of the ImmuneJoseph Lorenzo; Fiscal Year: 2006..The conference will be held on May 26, 2006 to June 2, 2006 in Crete, Greece. [unreadable] [unreadable] [unreadable] [unreadable]..
- Vascular Cell Regulation of ConnexinsBrant Isakson; Fiscal Year: 2005Cell-cell communication between endothelial cells (EC) and smooth muscle cells (SMC), provided by gap junctions, coordinates vessel contractility and electrical conduction...
- Chemokine Receptor Chimeras by Synthetic Gene LibraryMichael Dustin; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Inverted two photon laser scanning microscope for host defenseMichael Dustin; Fiscal Year: 2008..The impact on public health will be to develop better strategies to fight infections and reduce the incidence of pathogen triggered autoimmunity. [unreadable] [unreadable] [unreadable]..
- ImmunoreceptorsMichael Dustin; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable]..
- Epigenetic toxicity of polycyclic aromatic hydrocarbonsBrad Upham; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Glial Biology Gordon Research ConferenceVladimir Parpura; Fiscal Year: 2007..issues at the frontier of glial biology involving neuron and glib interactions, with strong emphasis on cell-cell communication. Major conference themes include glial control of neuronal functions, neuronal control of glial activities, ..
- Calcium-dependent glutamate release from astrocytesVladimir Parpura; Fiscal Year: 2008..Since astrocytes modulate synaptic transmission by releasing glutamate, this new insight into glial action has potential to change the way we think about central nervous system functions and dysfunctions [unreadable] [unreadable]..
- BIOMEDICAL POLYMERS--CELL ADHESION AND CYTOKINESJames Anderson; Fiscal Year: 2006....
- Hematopoietic Circadian RhythmsPeter Quesenberry; Fiscal Year: 2005..Transgenic Pert-luc rats and mice will be available at University of Virginia, and the array/informatic studies done at Princeton. ..
- LYMPHOCYTE/MACROPHAGE INTERACTIONS ON BIOMATERIALSJames Anderson; Fiscal Year: 2001..Results from our combined studies will lead to a greater appreciation of these complex cell/material interactions and novel design criteria for new biomaterials and tissue-engineered surfaces. ..
- INFECTION MECHANISMS WITH CARDIOVASCULAR PROSTHESESJAMES MORLEY ANDERSON; Fiscal Year: 2010..A fibrinogen-based peptide sequence based on fibrinogen/Fbe (S. epidermidis) will be used as a blocking ligand to investigate adhesion blocking mechanisms to prevent bacterial aggregation and biofilm formation. ..
- REGULATION OF MYOCARDIAL GAP JUNCTIONSJeffrey Saffitz; Fiscal Year: 2006..abstract_text> ..
- Zebrafish in Comparative Context: A SymposiumThomas Schilling; Fiscal Year: 2006..unreadable] [unreadable]..
- Carbohydrate-carbohydrate interaction in basic cell biologySen itiroh Hakomori; Fiscal Year: 2006..abstract_text> ..
- T Cell Activation in Lupus Proteomic CharacterizationJoseph Craft; Fiscal Year: 2005..abstract_text> ..
- Cell Interactions in Synapes Formation and FunctionJuan Bruses; Fiscal Year: 2005....
- Cryopreservation of the model organism Drosophila melanogasterBRENT SINCLAIR; Fiscal Year: 2007..The ultimate goal is to cryopreserve D. melanogaster, an achievement that will greatly increase the utility of the Drosophila model for human disease research. ..
- TGF BETA Regulation of Osteoclast ApoptosisMERRY OURSLER; Fiscal Year: 2007..Understanding osteoclast apoptosis regulation may provide important avenues for therapies to slow bone degradation during pathological bone loss. ..
- p120-catenin sub-family functionsPierre D McCrea; Fiscal Year: 2010....
- Molecular Mechanisms of Natural Killer Cell ActivationSubramaniam Malarkannan; Fiscal Year: 2010..Mechanisms identified here will not only have practical implications in tumor and graft immunity but will serve as models for other systems in which the responding cell must balance a number of activating and inhibitory inputs. ..
- Lymphocyte homeostastis & regulation during agingMICHAEL PAUL CANCRO; Fiscal Year: 2010..abstract_text> ..
- Toll-like receptors and intestinal inflammationCharalabos Pothoulakis; Fiscal Year: 2010..Our proposed studies will provide significant information relevant to the pathogenesis of colonic inflammation, including IBD. ..
- Angiogenic determinants of endogenous adult neurogenesisSteven Goldman; Fiscal Year: 2008....
- Regulation of T cell development by SOX13Joonsoo Kang; Fiscal Year: 2009..Collectively, the genetic program controlling T cell lineage commitment and maturation will be determined, allowing a better understanding of leukemogenesis. ..
- A novel method to discover genes that protect cells from alpha synucleinSTEPHAN WITT; Fiscal Year: 2007..This method allows us to screen libraries of genes- genes from any organism-to discover genes that protect against a-syn toxicity. [unreadable] [unreadable]..
- MSM-Multi-scale Analysis of Cellular Force Transmission and Biochemical ActivatioRoger Kamm; Fiscal Year: 2007..4. Conduct experiments in reconstituted actin networks to provide a pheonological basis for evaluation and evalidation of the computational models. ..
- Molecular Genetics of Midline Glial DevelopmentStephen T Crews; Fiscal Year: 2010..abstract_text> ..
- FILAMENTOUS INFLUENZA VIRUS AND MICROBIAL COLONIZATIONPaul Roberts; Fiscal Year: 2004..In parallel, we will also determine whether prior bacterial colonization can affect influenza virus replication in respiratory epithelium. ..
- Steroids and Stem Cell in CarcinogenesisDoris Benbrook; Fiscal Year: 2004..This research will enhance our understanding of the process of carcinogenesis and chemoprevention, which could ultimately translate into strategies and pharmaceuticals for prevention of cancer. ..
- PATHOBIOLOGY OF THE OSTEOCLAST IN PAGETS DISEASEG Roodman; Fiscal Year: 2002..abstract_text> ..
- B CELL DEFICIENCY IN A/WYSNJ MICEMichael Cancro; Fiscal Year: 2001....
- GENETIC CONTRIBUTION TO THE STRESS RESPONSEAntonio De Maio; Fiscal Year: 2002..The results from this analysis will provide us with candidate genes that contribute to the heterogeneity of the inflammatory response. ..
- GENETIC ANALYSIS OF PREHAIR MORPHOGENESISPaul Adler; Fiscal Year: 2005....
- PLASMALOPSYCHOSINE AS NEUROTROPHIC FACTORSenitiroh Hakomori; Fiscal Year: 2003..Results of these studies may provide a basis for development of PLPS and its analogues as therapeutic reagents for neurodegenerative diseases and neuronal injury. ..
- Genetic Etiologies of Esophageal Barrett's and CancerCharis Eng; Fiscal Year: 2003..This might facilitate molecular diagnostics and early prediction as well as targeted surveillance and prophylaxis. ..
- Ligand Binding Kinetics and Cell Adhesion by Fc ReceptorCheng Zhu; Fiscal Year: 2005..It may also provide guidance to the development of Fc-gamma-R- based drugs for treatment of inflammatory disorders and auto-immune diseases. ..
- CHEMISTRY AND BIOLOGY OF MALONDIALDEHYDE DNA ADDUCTSLAWRENCE MARNETT; Fiscal Year: 2004..The results of these experiments will define the chemistry and biology of a family of structurally dynamic lesions in the genome derived from an endogenous metabolic product of lipid oxidation. ..
- Transcriptional & cell cycle control by dietary indolesGARY FIRESTONE; Fiscal Year: 2008..This information will be particularly valuable to develop new classes of I3C-based therapeutics for reproductive cancers. ..
- Neuronal/Glial Interactions in Neuropathic PainPETER OHARA; Fiscal Year: 2008..These studies will serve to establish the role of neuron-glial cell communication in facial neuropathic pain...
- RADIOLOGICAL RESEARCH ACCELERATOR FACILITY (RARAF)David Brenner; Fiscal Year: 2002..abstract_text> ..
- KINETICS AND MECHANISM OF THE HEAT SHOCK 70 PROTEIN DNAKSTEPHAN WITT; Fiscal Year: 2002..abstract_text> ..
- Novel Small-Molecule Inhibitors of the Tie2/Angiopoietin Interactions and SignaliDimitar Nikolov; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- MECHANISMS OF AUTOREACTIVITY IN SLERobert Eisenberg; Fiscal Year: 2009..Such insights should be readily translatable to human autoimmune diseases. ..
- Mechanical regulation of selectin-ligand binding kineticsCheng Zhu; Fiscal Year: 2008..As a result, the data may offer new therapeutic approaches to inhibiting pathological cell adhesion during inflammation and thrombosis. ..
- MECHANISM(S) CONTROLLING GROWTH/MEIOSIS SWITCH IN YEASTSAUL HONIGBERG; Fiscal Year: 2002..To further examine this two-step control of differentiation, genes involved in nutritional control of late meiotic events are being identified, and their interactions with known meiotic regulators characterized (Specific Aim 3). ..
- NUMERICAL ANALYSIS OF FLOW AND TISSUE DEFORMATIONRoger Kamm; Fiscal Year: 2001..Specific Aim 3. To test the hypothesis that sites of inflammation/degradation correlate with regions within the tissue that experience high mechanical strain. ..
- BIOMECHANICAL EFFECT OF ACUPUNCTURE NEEDLINGHELENE LANGEVIN; Fiscal Year: 2001..This will contribute to the fundamental understanding of acupuncture therapy and may lead to improvements in treatments. ..
- TNFR Members in T Cell Immunity to VacciniaMichael Croft; Fiscal Year: 2010....
- Neural Crest Modulates FGF Signaling in the PharynxMargaret Loewy Kirby; Fiscal Year: 2010..Together these studies will advance the mechanistic understanding of neural crest function in heart development and will provide insight into factors that cause conotruncal malformations. ..
- POMC Processing and Beta-Endorphine-Related Opioid PeptidesVivian Y H Hook; Fiscal Year: 2010..New findings from this project will enhance our knowledge of the complexity of biosynthetic mechanisms for endogenous opioid and neuropeptide systems. ..
- RECEPTOR AGGREGATION AND ITS EFFECTSByron Goldstein; Fiscal Year: 2002..The studies in this project are health related, bearing on allergic reactions and their treatment as well as other aspects of the immune response. ..
- EXPRESSION OF HUMAN ERYTHROPOIETIN GENEGregg Semenza; Fiscal Year: 2002..abstract_text> ..
- The Role of Ductin in Embryonic MorphogenesisMichael Levin; Fiscal Year: 2007..unreadable] [unreadable]..
- Cellular Cardiomyoplasty in Vitro: Host-Donor Cell InteractionsNenad Bursac; Fiscal Year: 2007..The final aim is to aid in the development of efficient and safe cell-based approaches for the treatment of regional heart injury due to ischemia, infarction, or congenital defects. [unreadable] [unreadable] [unreadable]..
- NTPDase2 expression and function in the liverJONATHAN DRANOFF; Fiscal Year: 2005..The experiments proposed in these specific aims will provide the basis of several new lines of liver disease research and should provide novel therapeutic targets for treatment of cholestatic and fibrotic liver disease. ..
- Minimal Treatment Models of Stem Cell EngraftmentPeter Quesenberry; Fiscal Year: 2004..These studies should shed light on the stem cell/accessory cell mechanism involved in both syngeneic and allogeneic transplantation and provide approaches to minimize toxicity in both types of transplantation. ..
- MULTI-EPITOPE MELANOMA PEPTIDE VACCINATION WITH GM-CSFCraig Slingluff; Fiscal Year: 2004..abstract_text> ..
- CGRP CONTROL IN TRIGEMINAL NEURONS IN VITRO AND IN VIVOPaul Durham; Fiscal Year: 2006..abstract_text> ..
- Determination of Mechanism of T cell Lineage CommittmentJoonsoo Kang; Fiscal Year: 2006..The long-term objective of this application is to identify genes that determine T cell lineage fate. ..
- Visualization of gamma delta T cells in wound healingWENDY HAVRAN; Fiscal Year: 2005..Interesting initial results from this study will lead to new directions aimed at dissection of immune responses in epithelial tissues. ..
- High-Volume Confocal Imaging SystemStephen Crews; Fiscal Year: 2005..The Pascal will allow the labs to expeditiously and comprehensively study the cellular basis of embryonic development in combination with existing bright-field and spinning disk microscopes. ..
- CNS Lupus: Mechanistic DissectionJoseph Craft; Fiscal Year: 2006..unreadable] [unreadable]..
- Coordination of growth and patterning during developmentLaura Johnston; Fiscal Year: 2007..abstract_text> ..
- Challenges in the Era of Stem Cell PlasticityPeter Quesenberry; Fiscal Year: 2003..Participants will include investigators in the basic biology of stem cells, clinical transplanters, and clinician investigators. The workshops and symposium will be held in Providence, Rhode Island on April 8, 9, 10 & 11, 2003 ..
- Serpin Protease Inhibitors & Opioid NeuropeptidesVivian Hook; Fiscal Year: 2006..Serpin regulation of opioid peptides that mediate analgesia and stress may lead to development of new therapeutic approaches in pain and neurologic disease. ..
- Avian Influenza Virus Vaccines Bearing ImmunomodulatorsPaul Roberts; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- TRAINING IN CLINICAL INVESTIGATION FOR PHYSICIANSJoseph Craft; Fiscal Year: 2004..The curriculum takes maximum advantage of the strong training environment already in place in the Medical School. ..
- GENETIC ANALYSIS OF T CELLS IN LUPUSJoseph Craft; Fiscal Year: 2010..Delineation of the pathways that are required for the development and maintenance of systemic autoimmunity will ultimately help foster better understanding of T-B cell collaboration as a therapeutic target in SLE. ..
- Structure and mechanism of the AMP-activated protein kinaseLawrence Shapiro; Fiscal Year: 2010..Our preliminary results and the further work proposed will provide high-resolution structural information on AMPK, and should directly enable the rational design of AMPK-directed therapeutics. ..
- HMG-1/Y Regulation of NOS2 Expression in EndotoxemiaREBECCA BARON; Fiscal Year: 2007..These experiments will allow us to determine the role of HMG-I/Y in regulating NOS2 expression during endotoxemia and may reveal a novel target for improving outcomes from sepsis. [unreadable] [unreadable] [unreadable]..
- Gamma Delta T Cell ConferenceWENDY HAVRAN; Fiscal Year: 2006..Funds to support these goals will ensure that the 2006 gamma-delta T Cell Conference is an exciting forum for discussion of the latest information about gamma-delta T cells. ..
- Mice That Lack CDO: A Model for Mild HoloprosencephalyROBERT KRAUSS; Fiscal Year: 2004....
- Effects of Myostatin Deficiency on Bone StrengthMark Hamrick; Fiscal Year: 2007..abstract_text> ..
- Ig-Reactive T Cells in Rheumatoid ArthritisRussell Salter; Fiscal Year: 2003....
- Schwann Cell Spinal Remyelination in the RatPETER OHARA; Fiscal Year: 2006..abstract_text> ..
- CX43 IN A GENETIC MODEL OF ALTERED MYOCARDIAL CONDUCTIONJeffrey Saffitz; Fiscal Year: 2004..The results of the proposed research will define mechanisms by which reduced coupling promotes ventricular tachyarrhythmias in mouse models of acute and chronic ischemic heart disease in patients. ..
- Diabetes, Inflammation and Vascular DiseaseSusan Smyth; Fiscal Year: 2004..Moreover, our results may have broad implications for the treatment and prevent of accelerated atherosclerosis and thrombosis in diabetes. ..
- Hypoxia VHL nad HIF in Renal Tumor DevelopmentVolker Haase; Fiscal Year: 2008..Ultimately they have the potential to create a murine model of VHL associated renal tumors. ..
- Updating Chromosome Aberration Simulator (CAS) SoftwareRainer Sachs; Fiscal Year: 2006..An interdisciplinary team has been assembled for this project. The grant would ensure that a computer resource important to the radiation cytogenetics community is kept fully current and readily available. ..