physiological processes


Summary: The functions of living organisms, including both the physical and chemical factors and processes, supporting life in single- or multi-cell organisms from their origin through the progression of life.

Top Publications

  1. pmc Identifying blood biomarkers and physiological processes that distinguish humans with superior performance under psychological stress
    Amanda M Cooksey
    Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, Mississippi, United States of America
    PLoS ONE 4:e8371. 2009
  2. ncbi Integration from proteins to organs: the Physiome Project
    Peter J Hunter
    Bioengineering Institute, University of Auckland, New Zealand
    Nat Rev Mol Cell Biol 4:237-43. 2003
  3. ncbi Assessing physiological complexity
    W W Burggren
    Department of Biological Sciences, University of North Texas, Denton, TX 76203, USA
    J Exp Biol 208:3221-32. 2005
  4. pmc Computational biology of cardiac myocytes: proposed standards for the physiome
    Nicolas P Smith
    University Computing Laboratory, University of Oxford, Oxford, OX1 3QD, UK
    J Exp Biol 210:1576-83. 2007
  5. ncbi Revisiting the Krogh Principle in the post-genome era: Caenorhabditis elegans as a model system for integrative physiology research
    Kevin Strange
    Departments of Anesthesiology, Molecular Physiology and Biophysics, and Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Exp Biol 210:1622-31. 2007
  6. ncbi Beyond genomics
    C T Dollery
    GlaxoSmithKline, Harlow, UK
    Clin Pharmacol Ther 82:366-70. 2007
  7. pmc Stochastic regulation in early immune response
    Tomasz Lipniacki
    Institute of Fundamental Technological Research, Warsaw, Poland
    Biophys J 90:725-42. 2006
  8. ncbi The evolutionary origins and significance of vertebrate left-right organisation
    Jonathan Cooke
    Museum of Zoology, The University of Cambridge, Cambridge, UK
    Bioessays 26:413-21. 2004
  9. ncbi Reverse engineering of biological complexity
    Marie E Csete
    Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Science 295:1664-9. 2002
  10. pmc Noise in gene expression: origins, consequences, and control
    Jonathan M Raser
    Medical Scientist Training Program, University of California San Francisco, 600 16th Street, GH S472D, San Francisco, CA 94143 2240, USA
    Science 309:2010-3. 2005

Detail Information

Publications266 found, 100 shown here

  1. pmc Identifying blood biomarkers and physiological processes that distinguish humans with superior performance under psychological stress
    Amanda M Cooksey
    Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, Mississippi, United States of America
    PLoS ONE 4:e8371. 2009
    ..Some people are more resistant to this type of stress, and consequently better able to cope with the demands of naval aviation, than others...
  2. ncbi Integration from proteins to organs: the Physiome Project
    Peter J Hunter
    Bioengineering Institute, University of Auckland, New Zealand
    Nat Rev Mol Cell Biol 4:237-43. 2003
    ..The main project goals are to use computational modelling to analyse integrative biological function and to provide a system for hypothesis testing...
  3. ncbi Assessing physiological complexity
    W W Burggren
    Department of Biological Sciences, University of North Texas, Denton, TX 76203, USA
    J Exp Biol 208:3221-32. 2005
    ..Finally, we conclude with an invitation for physiologists, applied mathematicians and physicists to collaborate on describing, studying and learning from studies of physiological complexity...
  4. pmc Computational biology of cardiac myocytes: proposed standards for the physiome
    Nicolas P Smith
    University Computing Laboratory, University of Oxford, Oxford, OX1 3QD, UK
    J Exp Biol 210:1576-83. 2007
  5. ncbi Revisiting the Krogh Principle in the post-genome era: Caenorhabditis elegans as a model system for integrative physiology research
    Kevin Strange
    Departments of Anesthesiology, Molecular Physiology and Biophysics, and Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Exp Biol 210:1622-31. 2007
    ..elegans to develop a systems biological understanding of fundamental physiological processes common to all animals. I present examples of the experimental tools available for the study of C...
  6. ncbi Beyond genomics
    C T Dollery
    GlaxoSmithKline, Harlow, UK
    Clin Pharmacol Ther 82:366-70. 2007
  7. pmc Stochastic regulation in early immune response
    Tomasz Lipniacki
    Institute of Fundamental Technological Research, Warsaw, Poland
    Biophys J 90:725-42. 2006
    ..Our theoretical predictions of single cell kinetics are supported by recent experimental studies of oscillations in NF-kappaB signaling made on single cells...
  8. ncbi The evolutionary origins and significance of vertebrate left-right organisation
    Jonathan Cooke
    Museum of Zoology, The University of Cambridge, Cambridge, UK
    Bioessays 26:413-21. 2004
    ..I review the considerable evidence in favour of this scenario, and discuss its wider implications for directional asymmetries across the Metazoa...
  9. ncbi Reverse engineering of biological complexity
    Marie E Csete
    Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Science 295:1664-9. 2002
    ..This review describes insights from engineering theory and practice that can shed some light on biological complexity...
  10. pmc Noise in gene expression: origins, consequences, and control
    Jonathan M Raser
    Medical Scientist Training Program, University of California San Francisco, 600 16th Street, GH S472D, San Francisco, CA 94143 2240, USA
    Science 309:2010-3. 2005
    ..In this review, we summarize noise terminology and comment on recent investigations into the sources, consequences, and control of noise in gene expression...
  11. pmc Ligand accumulation in autocrine cell cultures
    Michael I Monine
    Department of Chemical Engineering and Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA
    Biophys J 88:2384-90. 2005
    ..We demonstrate how the theory works by analyzing the autocrine epidermal growth factor receptor system and discuss the extension of our methods to other experiments with cultured autocrine cells...
  12. ncbi A model of metabolic changes in respiration-deficient human cells
    F Mathias Bollmann
    Gymnasium Carolinum, Osnabruck, Germany
    Rejuvenation Res 10:327-33. 2007
    ..This hypothesis supports the view that some respiration-deficient cells are able to survive permanently within the body and contribute to human aging...
  13. ncbi Ontology recapitulates physiology
    Jeremy S Caldwell
    Department of Drug Discovery, Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA
    Chem Biol 10:784-6. 2003
    ..In response, researchers are devising computationally intensive and novel strategies to extract answers from multidimensional data sets...
  14. ncbi Avatars alive! The integration of physiology models and computer generated avatars in a multiplayer online simulation
    Laura Kusumoto
    Forterra Systems, Inc
    Stud Health Technol Inform 125:256-8. 2007
    ..The work is a collaboration between Forterra Systems and the SUMMIT group of Stanford University Medical School, and is sponsored by the US Army Medical Command's Telemedicine and Advanced Technologies Research Center (TATRC)...
  15. ncbi Theoretical morphology of developmental asymmetries
    Diego Rasskin-Gutman
    Gene Expression Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037 1099, USA
    Bioessays 26:405-12. 2004
  16. pmc Minding the gaps to promote thrombus growth and stability
    Lawrence F Brass
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 115:3385-92. 2005
  17. ncbi A novel theory: biological processes mostly involve two types of mediators, namely general and specific mediators Endogenous small radicals such as superoxide and nitric oxide may play a role of general mediator in biological processes
    Jian Mo
    The Fourth Military Medical University, 621 19, 17 Changlexilu, Xian 710032, PR China
    Med Hypotheses 65:728-35. 2005 the balance between the free radicals and the free radical scavengers would be of vital importance for physiological processes, and disturbance of these networks and balances would be a critical factor of pathological processes...
  18. ncbi Analyzing the reflections from single ommatidia in the butterfly compound eye with Voronoi diagrams
    Kurt J A Vanhoutte
    Department of Neurobiophysics, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands
    J Neurosci Methods 131:195-203. 2003
    ..We provide two typical examples to demonstrate that the developed technique may be a powerful tool to characterize in vivo the heterogeneity of butterfly eyes and to study the dynamic control of the light flux by the pupil mechanism...
  19. ncbi Evaluating elicited anxiety in a simulated environment
    Don Stredney
    OSC, Ohio Supercomputer Center, Columbus, OH, USA
    Stud Health Technol Inform 132:496-501. 2008
    ..We present on the components that comprise the environment, our study design, and preliminary results...
  20. ncbi Physiologic data acquisition system and database for the study of disease dynamics in the intensive care unit
    Brahm Goldstein
    Division of Pediatric Critical Care, Doernbecher Children s Hospital, Oregon Health Sciences University, Portland, USA
    Crit Care Med 31:433-41. 2003
    ..To describe a real-time, continuous physiologic data acquisition system for the study of disease dynamics in the intensive care unit...
  21. pmc Reactome: a knowledgebase of biological pathways
    G Joshi-Tope
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA
    Nucleic Acids Res 33:D428-32. 2005
    ..The database is publicly available under open source terms, which allows both its content and its software infrastructure to be freely used and redistributed...
  22. ncbi From fluctuations to phenotypes: the physiology of noise
    Michael S Samoilov
    Howard Hughes Medical Institute, Berkeley, CA 94720, USA
    Sci STKE 2006:re17. 2006
    ..eye color-vision development and Bacillus subtilis competence induction has elegantly traced the role of noise in vital physiological processes from fluctuations to phenotypes, and is used here to highlight these developments.
  23. ncbi WINSTODEC: a stochastic deconvolution interactive program for physiological and pharmacokinetic systems
    Giovanni Sparacino
    Dipartimento di Elettronica ed Informatica, Universita di Padova, Via Gradenigo 6 A, 35131, Padova, Italy
    Comput Methods Programs Biomed 67:67-77. 2002
    ..Automatica 33 (1997) 851-870). In this paper, an interactive program, WINSTODEC, is presented to allow the clinical investigator to easily obtain the solution of a deconvolution problem by this approach...
  24. ncbi Functional anatomy: a taxonomic proposal
    Ingvar Johansson
    Institute for Formal Ontology and Medical Information Science, University of Saarland, Saarbrucken, Postfach 151150, D 66041, Germany
    Acta Biotheor 53:153-66. 2005
    ..We propose formulae for constructing such a system and describe some of its benefits. The arguments are general enough to be of interest to all the life sciences...
  25. ncbi Direction dependent response of human skin
    Nobuyuki Tanaka
    Department of Artificial Complex Systems Engineering, The Graduate School of Engineering, Hiroshima University, Higashi Hiroshima, Hiroshima, Japan
    Conf Proc IEEE Eng Med Biol Soc 2007:1687-90. 2007
    ..By observing the deformation through a high speed camera, we newly found that the direction dependent response comes from the different deformation mechanism between phases...
  26. ncbi Age-related changes in the circadian and homeostatic regulation of human sleep
    Christian Cajochen
    Centre for Chronobiology, Psychiatric University Clinics, Basel, Switzerland
    Chronobiol Int 23:461-74. 2006
    ..Our data suggest that manipulations of the circadian timing system, rather than the sleep homeostat, may offer a potential strategy to alleviate age-related decrements in sleep and daytime alertness levels...
  27. ncbi Does the 1/f frequency scaling of brain signals reflect self-organized critical states?
    C Bedard
    Integrative and Computational Neuroscience Unit UNIC, CNRS, Gif sur Yvette, France
    Phys Rev Lett 97:118102. 2006
    ..We propose a model of 1/f scaling which does not rely on critical states, and which is testable experimentally...
  28. ncbi Sex differences in perceptual processing: performance on the color-Kanji stroop task of visual stimuli
    Xuezhu Shen
    Natural Science and Technology Division of Life Sciences, University of Kanazawa, Kanazawa, Japan
    Int J Neurosci 115:1631-41. 2005
    ..The P300 latency of males was longer and amplitude was smaller than females. The results suggest that cognitive strategy of males is different from females...
  29. ncbi The assessment of bone metabolism in vivo using biochemical approaches
    R G Russell
    Department of Human Metabolism and Clinical Biochemistry, University of Sheffield Medical School, United Kingdom
    Horm Metab Res 29:138-44. 1997
    ..It is important to remember that individual markers reflect different biochemical and physiological processes and may not, therefore, always show identical changes...
  30. ncbi Integrins in cell adhesion and signaling
    S K Akiyama
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Hum Cell 9:181-6. 1996
    Cell adhesive interactions play important roles during many normal physiological processes such as embryonic development and wound repair, and also during the progression of diseases such as cancer...
  31. ncbi Detection of VP-16-treated HL-60 cell apoptosis by TUNEL electron microscopy
    T Saitoh
    Third Department of Internal Medicine, Gunma University School of Medicine, Japan
    Ultrastruct Pathol 24:99-103. 2000
    Apoptosis is essential to many physiological processes, including maturation of cells and the immune system...
  32. pmc Role of oxidative stress in female reproduction
    Ashok Agarwal
    Center for Advanced Research in Human Reproduction, Infertility, and Sexual Function, Glickman Urological Institute and Department of Obstetrics Gynecology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Reprod Biol Endocrinol 3:28. 2005
    ..ROS are a double-edged sword - they serve as key signal molecules in physiological processes but also have a role in pathological processes involving the female reproductive tract...
  33. ncbi [Functional pathophysiology of consciousness]
    Kurt A Jellinger
    Institut für Klinische Neurobiologie, Wien
    Neuropsychiatr 23:115-33. 2009
    ..believed its special structure should be "a small gland in the middle", but the anatomical structures and physiological processes involved in consciousness were elucidated only in the middle of the 20th century...
  34. pmc Physiological consequences of the complete loss of phosphoryl-transfer proteins HPr and FPr of the phosphoenolpyruvate:sugar phosphotransferase system and analysis of fructose (fru) operon expression in Salmonella typhimurium
    D A Feldheim
    Department of Biology, University of California, San Diego, La Jolla 92093
    J Bacteriol 172:5459-69. 1990
    ..ptsI), and the proteins of cyclic AMP action (cya and crp) were analyzed for their effects on cellular physiological processes and expression of the fructose operon...
  35. ncbi The physiological and pharmacological significance of cardiovascular T-type, voltage-gated calcium channels
    D J Triggle
    State University of New York at Buffalo, 14260, USA
    Am J Hypertens 11:80S-87S. 1998 the opening of specific, voltage-gated channels, triggers muscular contraction and several other physiological processes. Two types of calcium channels, L-type and T-type, are found in the cardiovascular system...
  36. ncbi Targeted proteomics in the kidney using ensembles of antibodies
    M A Knepper
    Laboratory of Kidney and Electrolyte Metabolism, NHLBI, National Institutes of Health, Bethesda, MD 20892-1603, USA
    Acta Physiol Scand 173:11-21. 2001
    ..An ensemble of such probes can be exploited for comprehensive analysis of integrative physiological processes, approaches which are referred to as 'physiological genomics' or 'physiological proteomics'...
  37. ncbi Adenosine A2A receptor agonists inhibit lipopolysaccharide-induced production of tumor necrosis factor-alpha by equine monocytes
    Wan chun Sun
    Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, United States
    Vet Immunol Immunopathol 121:91-100. 2008
    Adenosine is an endogenous nucleoside that regulates many physiological processes by activating one or more adenosine receptor subtypes, namely A1, A2A, A2B and A3...
  38. ncbi Nasal nitric oxide
    L Lefevere
    ENT Department, UZ Leuven, Belgium
    Acta Otorhinolaryngol Belg 54:271-80. 2000
    ..In all of these it contributes to a number of (patho)physiological processes. Concerning the airways, NO concentrations in the upper respiratory tract are much higher (i.e...
  39. ncbi Intradialytic changes of serum magnesium and their relation to hypotensive episodes in hemodialysis patients on different dialysates
    Magdy M Elsharkawy
    Department of Internal Medicine and Nephrology, Faculty of Medicine, Ain Shams University, Cairo, Egypt
    Hemodial Int 10:S16-23. 2006
    Magnesium is a crucial mineral, involved in many important physiological processes. Magnesium plays a role of maintaining myocardial electrical stability in hemodialysis patients...
  40. ncbi Weight loss and delayed gastric emptying following a South American herbal preparation in overweight patients
    T Andersen
    Department of Ultrasound, Medical Center Charlottenlund, Trunnevangen 4A, DK 2920, Charlottenlund, Denmark
    J Hum Nutr Diet 14:243-50. 2001
    ..herbal preparations known to non-western cultures are materials which may have applications in modulating physiological processes which influence gut motility, food intake and energy balance...
  41. ncbi The pathophysiology of the onset of morning cardiovascular events
    M T Johnstone
    Institute for the Prevention of Cardiovascular Disease, Deaconess Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Am J Hypertens 9:22S-28S. 1996
  42. ncbi A PBS2 homologue from Debaryomyces hansenii shows a differential effect on calcofluor and polymyxin B sensitivity in Saccharomyces cerevisiae
    P K Bansal
    Institute of Microbial Technology, Sector 39A, Chandigarh 160 036, India
    Yeast 18:1207-16. 2001
    ..Thus, it appeared that Pbs2p also has an independent role in these two physiological processes. The GenBank Accession No. of this sequence is AF371315.
  43. ncbi Snake alpha-neurotoxin binding site on the Egyptian cobra (Naja haje) nicotinic acetylcholine receptor Is conserved
    Z Takacs
    Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Mol Biol Evol 18:1800-9. 2001
    ..that animal venoms are targeted against phylogenetically conserved molecular structures of fundamental physiological processes. Species producing venoms must be resistant to their action. Venoms of Elapidae snakes (e.g...
  44. ncbi Parallel activation of phosphatidylinositol 4-kinase and phospholipase C by the extracellular calcium-sensing receptor
    Chunfa Huang
    Division of Nephrology, Department of Medicine, Case Western Reserve University, Louis Stokes Veteran Affairs Medical Center, Cleveland, Ohio 44106, USA
    J Biol Chem 277:20293-300. 2002
    The calcium-sensing receptor (CaR) is a G protein-coupled receptor that regulates physiological processes including Ca(2+) metabolism, Na(+), Cl(-), K(+), and H(2)0 balance, and the growth of some epithelial cells through diverse ..
  45. ncbi Increased connexin43 expression in human saphenous veins in culture is associated with intimal hyperplasia
    Sebastien Deglise
    Department of Thoracic and Vascular Surgery, University Hospital, Lausanne, Switzerland
    J Vasc Surg 41:1043-52. 2005
  46. ncbi D-Serine exposure resulted in gene expression changes implicated in neurodegenerative disorders and neuronal dysfunction in male Fischer 344 rats
    Molly E Davidson
    Oak Ridge Institute for Science and Education, Columbus, OH 43201, USA
    Arch Toxicol 83:747-62. 2009
    D-Serine, an endogenous amino acid, is involved in many physiological processes through its interaction with the glycine binding site of the N-methyl-D-aspartate (NMDA) receptor...
  47. ncbi Inducible nitric oxide synthase is expressed in normal human melanocytes but not in melanoma cells in response to tumor necrosis factor-alpha, interferon-gamma, and lipopolysaccharide
    Lothar F Fecker
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Berlin, Germany
    J Invest Dermatol 118:1019-25. 2002
  48. ncbi Transfer to in vitro conditions influences expression and intracellular distribution of galectin-3 in murine peritoneal macrophages
    J Dumic
    Department of Biochemistry and Molecular Biology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Croatia
    Z Naturforsch C 55:261-6. 2000
    Galectin-3 is a beta-galactoside-binding lectin that has been implicated in numerous physiological processes, including mRNA splicing, cell differentiation, tumor metastasis and the stress response...
  49. ncbi Absorption, metabolism, and other factors that influence drug exposure in toxicology studies
    P R Mayer
    Pharmacodynamics Section, American Cyanamid, Pearl River, New York 10965, USA
    Toxicol Pathol 23:165-9. 1995
    ..Other factors, such as age, gender, and dosing interval need to be considered when interpreting toxicology studies...
  50. ncbi CD154 (CD40 ligand)
    U Schonbeck
    Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Ave, Boston, MA 02115, USA
    Int J Biochem Cell Biol 32:687-93. 2000
    ..Accordingly, CD40/CD154 interactions have advanced as a potential therapeutic target for these diseases, whereby two opposing strategies, interruption as well as enhancement of CD40 signaling, are explored for beneficial outcomes...
  51. ncbi Anti-inflammatory drugs in the 21st century
    K D Rainsford
    Biomedical Research Centre, Faculty of Health and Wellbeing, Sheffield Hallam University, Howard Street, Sheffield, SI 1WB, UK
    Subcell Biochem 42:3-27. 2007
    ..discovery and development of drugs to selectively control COX-2 and spare the COX-1 that is central to physiological processes whose inhibition was considered a major factor in development of adverse reactions, including those in ..
  52. pmc Microarray analysis of iron deficiency chlorosis in near-isogenic soybean lines
    Jamie A O'Rourke
    1Department of Genetics, Developmental and Cellular Biology, Iowa State University, Ames, Iowa 50011, USA
    BMC Genomics 8:476. 2007
    ..Soybean cultivars vary greatly in their ability to respond successfully to iron deficiency stress. Microarray analyses permit the identification of genes and physiological processes involved in soybean's response to iron stress.
  53. ncbi A genome-wide inventory of neurohormone GPCRs in the red flour beetle Tribolium castaneum
    Frank Hauser
    Center for Functional and Comparative Insect Genomics and Department of Cell Biology and Comparative Zoology, Institute of Biology, University of Copenhagen, Universitetsparken 15, DK 2100 Copenhagen, Denmark
    Front Neuroendocrinol 29:142-65. 2008
    ..GPCRs) play a central role in the control of behavior, reproduction, development, feeding and many other physiological processes. The recent completion of several insect genome projects has enabled us to obtain a complete inventory of ..
  54. ncbi Possible mechanisms underlying the antiaging actions of caloric restriction
    E J Masoro
    University of Texas Health Science Center at San Antonio 78284 7756, USA
    Toxicol Pathol 24:738-41. 1996
    ..a decrease in the age-associated increase in age-specific mortality rate, the maintenance of the physiological processes in a youthful state even at advanced ages, and the delaying of the onset or slowing of the progression or ..
  55. pmc Expression of muscarinic receptor subtypes in tree shrew ocular tissues and their regulation during the development of myopia
    N A McBrien
    Department of Optometry and Vision Sciences, The University of Melbourne, Victoria, Australia
    Mol Vis 15:464-75. 2009
    ..However, their site of action is unknown. This study details ocular muscarinic subtype expression within a well documented model of eye growth and investigates their expression during early stages of myopia induction...
  56. pmc GeneMesh: a web-based microarray analysis tool for relating differentially expressed genes to MeSH terms
    Saurin D Jani
    Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29425, USA
    BMC Bioinformatics 11:166. 2010
  57. ncbi Targeting adenosine receptors: novel therapeutic targets in asthma and chronic obstructive pulmonary disease
    Steuart Rorke
    Division of Respiratory Cell and Molecular Biology, University of Southampton School of Medicine, Southampton General Hospital, Southampton, UK
    Am J Respir Med 1:99-105. 2002
    Adenosine, an endogenous signaling nucleoside that modulates many physiological processes has been implicated in playing an ever increasingly important role in the pathogenesis of asthma and chronic obstructive pulmonary disease (COPD)...
  58. ncbi Chaos and physiology: deterministic chaos in excitable cell assemblies
    T Elbert
    Institute for Experimental Audiology, University of Munster, Germany
    Physiol Rev 74:1-47. 1994
    ..that by analogy corresponds to nature as we see it, the question remains as to its ultimate meaning for physiological processes. It was our intent to help clarify this somewhat popular, somewhat obscure area of nonlinear dynamics in ..
  59. ncbi Antioxidants and phase 2 enzymes in macrophages: regulation by Nrf2 signaling and protection against oxidative and electrophilic stress
    Hong Zhu
    Division of Biomedical Sciences, Edward Via Virginia College of Osteopathic Medicine, Virginia Tech Corporate Research Center Research Building II, 1861 Pratt Drive, Blacksburg, VA 24060, USA
    Exp Biol Med (Maywood) 233:463-74. 2008
    Macrophages play important roles in immunity and other physiological processes. They are also target cells of various toxic agents, including oxidants and electrophiles...
  60. ncbi Daily temporal organization of laying in Japanese quail: variability and heritability
    Cecilia Houdelier
    UMR 6552, Ethologie Eolution Ecologie, Universite de Rennes 1 CNRS, France
    Chronobiol Int 19:377-92. 2002
    In birds, many behavioral and physiological processes that occur during reproduction show daily rhythms in response to environmental temporal constraints...
  61. ncbi Inhibition of glycogen synthase kinase 3 improves insulin action and glucose metabolism in human skeletal muscle
    Svetlana E Nikoulina
    Veterans Affairs San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    Diabetes 51:2190-8. 2002
    Glycogen synthase kinase (GSK)-3 has been implicated in the regulation of multiple cellular physiological processes in skeletal muscle...
  62. ncbi Aromatase, aromatase inhibitors, and breast cancer
    R W Brueggemeier
    Medicinal Chemistry and Pharmacognosy, College of Pharmacy, and Hormones and Cancer Program, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
    Am J Ther 8:333-44. 2001
  63. ncbi Insulin and insulin-like growth factor-1 modulation of glucose transport in arterial smooth muscle cells: implication of GLUT-4 in the vasculature
    P R Standley
    Department of Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201
    Am J Hypertens 7:357-62. 1994
    Insulin modulates many physiological processes in vascular smooth muscle cells (VSMC) such as contractility, proliferation, and ion homeostasis...
  64. ncbi Modeling gastrointestinal drug absorption requires more in vivo biopharmaceutical data: experience from in vivo dissolution and permeability studies in humans
    Hans Lennernas
    Department of Pharmacy, Uppsala University, Uppsala, Sweden
    Curr Drug Metab 8:645-57. 2007
    ..development of oral pharmaceutical products require an in-depth understanding of multiple biochemical and physiological processes that determine the dissolution rate, intestinal permeability, gastrointestinal transit, first-pass ..
  65. ncbi The ROR nuclear orphan receptor subfamily: critical regulators of multiple biological processes
    A M Jetten
    Cell Biology Section, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, North Carolina 27709, USA
    Prog Nucleic Acid Res Mol Biol 69:205-47. 2001
    ..These proteins function as key regulators of many physiological processes that occur during embryonic development and in the adult...
  66. ncbi Lizards, lipids, and dietary links to animal function
    E T Simandle
    Department of Biology, Colorado State University, Fort Collins, CO 80523 1878, USA
    Physiol Biochem Zool 74:625-40. 2001
    Our experiments were designed to test the hypotheses that dietary lipids can affect whole-animal physiological processes in a manner concordant with changes in the fluidity of cell membranes...
  67. ncbi [Dioxins and food safety]
    Paweł Struciński
    Zakład Toksykologii Srodowiskowej, Narodowy Instytut Zdrowia Publicznego Pańistwowy Zakład Higieny, Warszawa
    Rocz Panstw Zakl Hig 62:3-17. 2011
    ..of epidemiological studies suggest that environmental exposure to these compounds may affect multiple physiological processes in humans, mainly by the mechanism of endocrine disruption...
  68. ncbi Inhibition of stress-induced adrenocorticotropin and prolactin secretion mediating hypophysiotropic factors by antagonist of AMPA type glutamate receptor
    Shinji Kusakawa
    Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, Japan
    J Reprod Dev 53:545-54. 2007
    Glutamate is the dominant excitatory neurotransmitter in a large number of physiological processes including neuroendocrine regulation...
  69. pmc Different functions of the insect soluble and membrane-bound trehalase genes in chitin biosynthesis revealed by RNA interference
    Jie Chen
    State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat Sen University, Guangzhou, China
    PLoS ONE 5:e10133. 2010 enzyme that hydrolyzes trehalose to yield two glucose molecules, plays a pivotal role in various physiological processes. In recent years, trehalase proteins have been purified from several insect species and are divided into ..
  70. pmc Functional characterization of a three-component regulatory system involved in quorum sensing-based regulation of peptide antibiotic production in Carnobacterium maltaromaticum
    Bettina H Rohde
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York City, USA
    BMC Microbiol 6:93. 2006
    Quorum sensing is a form of cell-to-cell communication that allows bacteria to control a wide range of physiological processes in a population density-dependent manner...
  71. ncbi Serum leptin levels in patients with primary hyperaldosteronism before and after treatment: relationships to insulin sensitivity
    M Haluzik
    Third Department of Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic
    J Hum Hypertens 16:41-5. 2002
    Leptin is a protein hormone produced predominantly by adipocytes that plays a role in food intake regulation and a series of other physiological processes including blood pressure regulation.
  72. pmc Unraveling the evolutionary history of the phosphoryl-transfer chain of the phosphoenolpyruvate:phosphotransferase system through phylogenetic analyses and genome context
    Iñaki Comas
    Instituto de Agroquimica y Tecnologia de Alimentos, CSIC, Valencia, Spain
    BMC Evol Biol 8:147. 2008
    ..phosphotransferase system (PTS) plays a major role in sugar transport and in the regulation of essential physiological processes in many bacteria...
  73. ncbi Impacts of elevated atmospheric CO2 and O3 on forests: phytochemistry, trophic interactions, and ecosystem dynamics
    Richard L Lindroth
    Department of Entomology, University of Wisconsin, Madison, WI 53706, USA
    J Chem Ecol 36:2-21. 2010
    ..CO2 and O3 influence phytochemical composition by altering substrate availability and biochemical/physiological processes such as photosynthesis and defense signaling pathways...
  74. ncbi Vacuolar type H+ pumping pyrophosphatases of parasitic protozoa
    Michael T McIntosh
    Department of Microbiology and Immunology, MCP Hahnemann School of Medicine, Philadelphia, PA 19129, USA
    Int J Parasitol 32:1-14. 2002
    Trans-membrane proton pumping is responsible for a myriad of physiological processes including the generation of proton motive force that drives bioenergetics...
  75. ncbi Phototropin involvement in the expression of genes encoding chlorophyll and carotenoid biosynthesis enzymes and LHC apoproteins in Chlamydomonas reinhardtii
    Chung Soon Im
    Department of Plant Biology, Carnegie Institution, Stanford, CA 94306, USA
    Plant J 48:1-16. 2006
    Phototropin (PHOT) is a photoreceptor involved in a variety of blue-light-elicited physiological processes including phototropism, chloroplast movement and stomatal opening in plants...
  76. ncbi Smad4 and ERK2 stimulated by transforming growth factor beta1 in rhabdomyosarcoma
    Hua Guo
    Department of Pathology, Peking University First Hospital, Beijing 100034, China
    Chin Med J (Engl) 120:515-21. 2007
    ..In the present study, we examined the expression and functional relations of extracellular signal-regulated kinase 2 (ERK2) and Smad4 in human RMS tissue and a RMS cell line, RD...
  77. ncbi [Thiamine and its derivatives in the regulation of cell metabolism]
    Adam Tylicki
    Instytut Biologii, Uniwersytet w Białymstoku
    Postepy Hig Med Dosw (Online) 65:447-69. 2011
    ..biochemists and medical doctors because of its multilateral participation in key biochemical and physiological processes. The thiamine molecule is composed of pyrimidine and thiazole rings which are linked by a methylene ..
  78. ncbi Nitric oxide stimulates human sperm motility via activation of the cyclic GMP/protein kinase G signaling pathway
    Erica Miraglia
    Department of Genetics, Biology and Biochemistry, University of Torino, Via Santena 5 bis, Turin, Italy
    Reproduction 141:47-54. 2011
    Nitric oxide (NO), a modulator of several physiological processes, is involved in different human sperm functions...
  79. pmc Rapid preparation of nuclei-depleted detergent-resistant membrane fractions suitable for proteomics analysis
    Rosalyn M Adam
    Urological Diseases Research Center, Children s Hospital Boston and Department of Surgery, Harvard Medical School, Boston, MA 02115, USA
    BMC Cell Biol 9:30. 2008
    ..To address these issues, we have modified a published differential detergent extraction method to enable rapid DRM isolation that minimizes nuclear contamination and yields fractions compatible with mass spectrometry...
  80. ncbi Murine renal organic anion transporters mOAT1 and mOAT3 facilitate the transport of neuroactive tryptophan metabolites
    Andrew Bahn
    Zentrum für Physiologie und Pathophysiologie, Abt Vegetative Physiologie und Pathophysiologie, Universitat Gottingen, Humboldtallee 23, D 37073 Gottingen, Germany
    Am J Physiol Cell Physiol 289:C1075-84. 2005
    ..kynurenate (KYNA), xanthurenate (XA), and quinolinate are considered to have an important impact on many physiological processes, especially brain function. Many of these metabolites are secreted with the urine...
  81. ncbi Synthesis, purification and bioactivity of recombinant human activin A expressed in the yeast Pichia pastoris
    Theo Papakonstantinou
    ARC Special Research Centre for Green Chemistry, Building 75, Monash University, Clayton, Victoria 3800, Australia
    Protein Expr Purif 64:131-8. 2009
    ..factor-beta (TGF-beta) superfamily member, activin A, plays a central role in the regulation of multiple physiological processes including cell differentiation, mitogenesis, embryogenesis, apoptosis and inflammation...
  82. ncbi Decreased Hill reaction rates and slow turnover of transitory starch in the obligate shade plant Panax quinquefolius L. (American ginseng)
    Julie Ann Miskell
    Biochemistry Department, University of Otago, P O Box 56, Dunedin, New Zealand
    Planta 215:969-79. 2002
    To identify physiological processes that might limit photosynthesis in Panax quinquefolius L. (American ginseng) a comparison has been made with Panax ginseng C.A. Meyer (Korean ginseng), Pisum sativum L. (pea) and Spinacia oleracea L...
  83. pmc Regulation and isoform function of the V-ATPases
    Masashi Toei
    Department of Physiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Biochemistry 49:4715-23. 2010
    ..Intracellular V-ATPases play an important role in normal physiological processes such as receptor-mediated endocytosis, intracellular membrane trafficking, pro-hormone processing, ..
  84. ncbi Pharmacokinetic considerations in clinical toxicology: clinical applications
    Darren M Roberts
    South Asian Clinical Toxicology Research Collaboration, Medical School, Australian National University, Canberra, Australia
    Clin Pharmacokinet 46:897-939. 2007
    ..This may result from saturation of the capacity of a number of physiological processes due to the high dose, or the toxic effects of the poison may change these processes directly...
  85. ncbi Two juvenile hormone esterase-like carboxylesterase cDNAs from a Pandalus shrimp (Pandalopsis japonica): cloning, tissue expression, and effects of eyestalk ablation
    Sun Ok Lee
    Department of Marine Biology, Pukyong National University, Busan, South Korea
    Comp Biochem Physiol B Biochem Mol Biol 159:148-56. 2011
    ..MF), a crustacean juvenile hormone (JH) analog, plays important roles in the regulation of a number of physiological processes such as molting, metamorphosis, and reproduction...
  86. ncbi Analysis of the importance of lipid breakdown for elimination of okadaic acid (diarrhetic shellfish toxin) in mussels, Mytilus edulis: results from a field study and a laboratory experiment
    Susanne Svensson
    Department of Marine Ecology, Tjärnö Marine Biological Laboratory, S 452 96 Strömstad, Sweden
    Aquat Toxicol 66:405-18. 2004
    ..cost-effective depuration methods for DSP toxins, knowledge about the environmental conditions and physiological processes regulating the rate of depuration is essential...
  87. pmc Functional linkages for the pace of life, life-history, and environment in birds
    Joseph B Williams
    Department EEOB, Ohio State University, Columbus, OH 43210, USA
    Integr Comp Biol 50:855-68. 2010
    ..Although it is widely acknowledged that physiological processes serve as a foundation for life-history trade-offs, the physiological mechanisms that underlie the ..
  88. pmc Exploring the midgut transcriptome of Phlebotomus papatasi: comparative analysis of expression profiles of sugar-fed, blood-fed and Leishmania-major-infected sandflies
    Marcelo Ramalho-Ortigao
    Vector Molecular Biology Unit, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    BMC Genomics 8:300. 2007
    ..Furthermore, we compared the transcript expression profiles from the three different cDNA libraries by customized bioinformatics analysis and validated these findings by semi-quantitative PCR and real-time PCR...
  89. ncbi Endothelial cell migration on surface-density gradients of fibronectin, VEGF, or both proteins
    Lingyun Liu
    Department of Bioengineering, University of Washington, Seattle, Washington 98195, USA
    Langmuir 23:11168-73. 2007
    Cell migration is essential to many physiological processes, including angiogenesis, which is critical to the success of implanted biomaterials and tissue-engineered constructs. Gradients play an important role in cell migration...
  90. pmc Identification and expression analysis of WRKY transcription factor genes in canola (Brassica napus L.) in response to fungal pathogens and hormone treatments
    Bo Yang
    Department of Agricultural, Food and Nutritional Science, Edmonton, Alberta, Canada
    BMC Plant Biol 9:68. 2009
    ..of plant WRKY transcription factor families are widely implicated in defense responses and various other physiological processes. For canola (Brassica napus L.), no WRKY genes have been described in detail...
  91. ncbi Alpha-aminoxy acids: new possibilities from foldamers to anion receptors and channels
    Xiang Li
    Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, China
    Acc Chem Res 41:1428-38. 2008
    ..serve important functions as enzyme inhibitors, hormones, neurotransmitters, and immunomodulators in many physiological processes including metabolism, digestion, pain sensitivity, and the immune response...
  92. ncbi Characterisation of capn1, capn2-like, capn3 and capn11 genes in Atlantic halibut (Hippoglossus hippoglossus L.): Transcriptional regulation across tissues and in skeletal muscle at distinct nutritional states
    Daniel J Macqueen
    Scottish Oceans Institute, University of St Andrews, Fife, UK
    Gene 453:45-58. 2010
    The typical calpain proteases are a subset of a wider superfamily and regulate a broad spectrum of physiological processes. Here we characterised Atlantic halibut complete-coding orthologues of calpain-1, calpain-2-like, "muscle-specific"..
  93. ncbi The role of stress in neurodegenerative diseases and mental disorders
    Tobias Esch
    The Mind Body Medical Institute, CareGroup and Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston MA 02215, USA
    Neuro Endocrinol Lett 23:199-208. 2002
    ..Evidence for a connection between stress and selected neurodegenerative diseases as well as mental disorders is analyzed. Does stress cause or exacerbate related pathophysiological disease processes?..
  94. ncbi Snake toxins with high selectivity for subtypes of muscarinic acetylcholine receptors
    E Karlsson
    Department of Physiology, Biomedical Centre, Box 572, 751 23, Uppsala, Sweden
    Biochimie 82:793-806. 2000
    ..are five subtypes of muscarinic acetylcholine receptors (M(1) to M(5)) which control a large number of physiological processes, such as the function of heart and smooth muscles, glandular secretion, release of neurotransmitters, ..
  95. ncbi Body temperature null distributions in reptiles with nonzero heat capacity: seasonal thermoregulation in the American alligator (Alligator mississippiensis)
    Frank Seebacher
    School of Biological Sciences A08, University of Sydney, Sydney, New South Wales 2006, Australia
    Physiol Biochem Zool 76:348-59. 2003
    Regulation of body temperature may increase fitness of animals by ensuring that biochemical and physiological processes proceed at an optimal rate...
  96. ncbi Effects of light quality on CO2 assimilation, chlorophyll-fluorescence quenching, expression of Calvin cycle genes and carbohydrate accumulation in Cucumis sativus
    Hong Wang
    Department of Horticulture, Huajiachi Campus, Zhejiang University, Kaixuan Road 268, Hangzhou, PR China
    J Photochem Photobiol B 96:30-7. 2009
    Light quality is thought to affect many plant physiological processes during growth and development, particularly photosynthesis...
  97. ncbi Diurnal variation in thermoregulatory response to chlorpyrifos and carbaryl in the rat
    C J Gordon
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, MD 74B, Research Triangle Park, NC, 27711, USA
    Toxicology 169:93-105. 2001
    ..would be expected that the circadian temperature rhythm (CTR) as well as the circadian rhythms of other physiological processes would affect the efficacy of anticholinesterase (antiChE) insecticides...
  98. ncbi [Gene cloning, sequence analysis and tissue expression of estrogen-related receptor alpha (Erralpha) in Japanese medaka and its transcriptional responses after differential EDCs exposure]
    Zhao Bin Zhang
    College of Urban and Environmental Sciences, Peking University, Beijing 100871, China
    Huan Jing Ke Xue 29:3153-8. 2008
    ..receptors (ERRs), belonging to the nuclear receptor superfamily, have been implicated in diverse physiological processes in estrogen signal pathway in mammals, while little is known about them in fishes...
  99. ncbi A decade of developments in the area of fat supplementation research with beef cattle and sheep
    B W Hess
    Department of Animal Science, University of Wyoming, Laramie, Wyoming 82071 3684, USA
    J Anim Sci 86:E188-204. 2008
    Supplementing ruminant animal diets with fat has been investigated as a means to influence a variety of physiological processes or to alter fatty acid composition of food products derived from ruminant animals...
  100. pmc Nuclear receptor complement of the cnidarian Nematostella vectensis: phylogenetic relationships and developmental expression patterns
    Adam M Reitzel
    Department of Biology, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA
    BMC Evol Biol 9:230. 2009
    ..receptors are a superfamily of metazoan transcription factors that regulate diverse developmental and physiological processes. Sequenced genomes from an increasing number of bilaterians have provided a more complete picture of ..
  101. ncbi Biochemical genetics revisited: the use of mutants to study carbon and nitrogen metabolism in the photosynthetic bacteria
    J C Willison
    Departement de Biologie Moleculaire et Structurale, Centre d Etudes Nucleaires de Grenoble, France
    FEMS Microbiol Rev 10:1-38. 1993
    ..use of mutants, in comparative studies with the wild-type, to obtain information about biochemical and physiological processes in complex metabolic systems...

Research Grants74

    DHAN V KALVAKOLANU; Fiscal Year: 2013
    ..Studies proposed in this application will investigate the regulation of an anti-metastatic gene, DAPK1, which is critical for tumor suppression and autophagic responses. ..
  2. Biology of IGFs in Bone
    Thomas L Clemens; Fiscal Year: 2013 applicant): The insulin-like growth factors evolved in lower animalsto enable a wide range of physiological processes including smell, food consumption, metabolism, growth, reproduction and dormancy...
  3. Studying the effects of vitamin D on FOXP3 and IL-17 expression in human CD4+ T c
    Insoo Kang; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Vitamins and their metabolites are essential for a number of physiological processes including regulating the immune systems...
  4. Microsomal Cytochromes P450 and their Interactions with their Redox Partners
    Lucy A Waskell; Fiscal Year: 2013
  5. Role of MicroRNA mi R-33 in Controlling Cholesterol/Lipid Homeostasis
    Anders M Naar; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Cholesterol and fatty acids play critical functional roles in many physiological processes in metazoans, such as modulating membrane fluidity, serving as signaling molecules, and providing energy ..
  6. Histone Chaperones in Angiogenesis
    Soumen Paul; Fiscal Year: 2012
    ..Angiogenesis, the development of new blood vessels from existing vasculature, is a key event in many physiological processes, like organ growth and development, wound healing, and reproduction...
  7. Developing miRNA diagnostic methods and identifying tumor regulatory networks
    Thomas Tuschl; Fiscal Year: 2010
    ..RELEVANCE: miRNAs are recently identified small non-coding RNAs that regulate many developmental and physiological processes including cancer...
  8. Nitric Oxide Signaling with Heme Proteins
    William R Montfort; Fiscal Year: 2012
    ..Yet, NO is produced in all mammalian tissues and is central to a wide-ranging array of physiological processes, including vasodilation, blood coagulation, memory formation, inflammation, angiogenesis, cell growth and ..
  9. Interacting Impact of Adrenal and Ovarian Aging on the CNS
    Henryk F Urbanski; Fiscal Year: 2011
    ..DHEA release exacerbates the perimenopausal decline in estradiol, and thereby negatively impacts central physiological processes such as cognition, learning, and attention, and leads to perturbation of the circadian sleep-wake cycle...
  10. FASEB SRC on Mitochondrial Assembly &Dynamics in Health, Disease &Aging
    Antoni Barrientos; Fiscal Year: 2011
    ..Seminal advances have occurred in recent years on physiological processes within the organelle such as the dynamics of morphology, mitophagy, protein import into sub-compartments, ..
  11. Molecular physiology of voltage-gated Ca2+ channels
    Jian Yang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Voltage-gated calcium channels (VGCCs) control and regulate numerous physiological processes, ranging from muscle contraction, heartbeat, neural communication and hormone secretion to cell ..
  12. ANP Receptor: Molecular approach of signaling mechanisms
    Kailash N Pandey; Fiscal Year: 2013
    ..on NPRA as an approach to gain increased understanding of the normal and abnormal control of cellular and physiological processes. These goals are as follows: 1) delineate the molecular determinants in the GC catalytic active-site of ..
  13. ECM compliance and cell cycle control
    RICHARD ASSOIAN; Fiscal Year: 2012
    The extracellular matrix (ECM) controls a large number of physiological processes including differentiation, apoptosis, and proliferation...
  14. Development of Bioactive Chemical Probes for Calcium-activated Chloride Channel
    Min Li; Fiscal Year: 2012
    ..Its role is implicated in numerous physiological processes including cardiac and neuronal excitation, sensory transduction, trans-epithelial secretion, smooth ..
  15. Primate Fetal Adrenal Development: Impact on Physiological Processes After Birth
    Eugene D Albrecht; Fiscal Year: 2013
  16. Perinatal Programming of Infant Stress Reactivity and the Atopic Phenotype
    Rosalind J Wright; Fiscal Year: 2013
    ..g., depression, PTSD), which exert effects on physiological processes that influence disease risk...
  17. Structure and function of chloride channels and transporters
    Alessio Accardi; Fiscal Year: 2013 applicant): Chloride channels and transporters of the CLC family play crucial roles in a myriad of physiological processes including regulation of electrical excitability of nerve and muscle cells, modulation of salt and water ..
  18. A Functional Role for the Circadian Clock Protein Per1 in the Regulation of ??ENa
    Michelle L Gumz; Fiscal Year: 2013
    ..Many physiological processes exhibit a circadian pattern, including the sleep-wake cycle, heart beat, hormone secretion, renal blood ..
  19. Melanopsin Signal Transduction Studied by FTIR Spectroscopy
    Kenneth J Rothschild; Fiscal Year: 2012
    ..Understanding melanopsin is important because it is involved in key physiological processes including sleep, mental alertness, eating habits, and hormonal levels as well as disorders involving ..
  20. Nuclear Lipids in Steroidogenesis
    Marion B Sewer; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Steroid hormones are key regulators of a diverse array of physiological processes, including sodium homeostasis, reproduction, and the development of secondary sex characteristics...
  21. Transcriptional regulation of enteroendocrine cell differentiation by NeuroD
    Andrew B Leiter; Fiscal Year: 2013
    ..represent less than 5% of the total number of epithelial cells but secrete hormones that control numerous physiological processes including appetite and satiety, insulin secretion, and digestive organ function...
  22. Ligand Interaction of Glucagon Receptor by Structural and Functional Analyses
    FAI YIU SIU; Fiscal Year: 2012
    ..They are involved in many physiological processes and implicated in numerous human diseases...
  23. Genome-wide Identification of Immediate Early Genes in Insects
    Anandasankar Ray; Fiscal Year: 2012
    ..In mammals activity-regulated genes have been associated with a number of important physiological processes such as nervous system function and cancer biology, and the ability to study them in the model insect ..
    Salman Azhar; Fiscal Year: 2013
    ..produced by the liver and adrenal/gonads, respectively, and are essential for a multitude of normal physiological processes. Bile acids play essential roles in facilitating lipid digestion and absorption, and also serve as ..
    J Kevin Foskett; Fiscal Year: 2013
    ..The InsP3R participates in generation of complex Ca2+ signals that regulate many physiological processes in cells, including, as we have discovered, autophagy and basal metabolism, as well as cell survival and ..
  26. The Effect of Behavioral and Physiological Factors on Obesity Risk in Children
    Karen B Dorsey; Fiscal Year: 2012
    ..Dorsey realized that her limited knowledge of nutrition, physical activity, and other physiological processes that determine weight gain left her ill prepared to help her overweight patients...
  27. Seahorse XF96 Extracellular Flux Analyzer
    Enrique Saez; Fiscal Year: 2013
    TIMOTHY CRAGIN WANG; Fiscal Year: 2013
    ..abstract_text> ..
  29. Participation in Cytochrome b5 in Anesthetic Metabolism
    Lucy A Waskell; Fiscal Year: 2010
  30. The evolutionary and molecular mechanisms underlying sperm performance in an emer
    Heidi S Fisher; Fiscal Year: 2013
    ..success in laboratory mice have provided important insights into the molecular, developmental and physiological processes underlying mammalian reproduction and have served as models for studies of human infertility...
  31. Centrosomin and Centrosomes in Cell Division
    Timothy L Megraw; Fiscal Year: 2012
    ..and centrosomes cause a host of human disorders due to their importance in so many developmental and physiological processes. These ailments include polycystic kidney disease, deafness, hydrocephaly, obesity, microcephaly, and ..
  32. Isoform specific effects of the autoinhibitory element and the C-terminus of nitr
    JOHN SALERNO; Fiscal Year: 2009
    Nitric oxide synthases play multiple roles in such diverse physiological processes as control of vascular tone, signal transduction in the central nervous system, and immune response...
  33. Mediator and epigenetic control of neuronal gene expression and differentiation
    Thomas G Boyer; Fiscal Year: 2013
    ..from activator and repressor proteins to affect changes in gene expression programs that control diverse physiological processes, including cell growth and homeostasis, development, and differentiation...
  34. Gene Regulation by and of LEDGF
    Dhirendra P Singh; Fiscal Year: 2012 LEDGF functions at the cellular and molecular levels, how it regulates cellular survival and other physiological processes, how these processes go awry in various disease states, and how the expression levels of LEDGF are ..
  35. Genome-wide epigenetic control of circadian metabolism by heme receptor Rev-erb
    Mitchell A Lazar; Fiscal Year: 2010
    ..circadian and metabolic genes will be enormous, and contribute greatly to our understanding of how these physiological processes are interrelated, and potentially dysregulated in obesity and diabetes, which are epidemic in the United ..
  36. Protein methyltransferases as transcriptional coregulators
    Michael R Stallcup; Fiscal Year: 2013
    ..of how a variety of hormones regulate the activities of specific genes and thereby control important physiological processes such as sexual development, response to stress, and glucose and fatty acid metabolism...
  37. Protein Kinase D2 Function and Signaling in Angiogenesis
    Hua Tang; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Angiogenesis plays a crucial role in numerous physiological processes and in a wide variety of pathological conditions of human diseases, including ischemic vascular diseases, atherosclerosis, tumor ..
  38. Cellular Determinants of Ah Receptor Signaling
    Thomas R Sutter; Fiscal Year: 2013
    ..The results of these studies will generate the knowledge that is necessary to design minimally invasive studies using small skin biopsies and tape stripping methods in future translational studies of human populations exposed to dioxin. ..
  39. Investigating the Mechanisms Regulating RORgamma Activity
    LAURA ANN SOLT; Fiscal Year: 2013 Specific Aim 3 we will determine the effects of natural and synthetic ligands on ROR3 regulated physiological processes. These studies are essential for our understanding of how ligands may coordinate ROR3 regulated functions...
  40. Functional Anatomy of REM Sleep: Brainstem-Control
    Gerald A Marks; Fiscal Year: 2013
    ..Rapid eye movement (REM) sleep is a stage of sleep constituted by the concurrent appearance of many physiological processes and comprises about 20% of total sleep in adult humans...
  41. The Regulation of Inflammatory Responses by CD73
    Linda F Thompson; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Adenosine modulates many important physiological processes by triggering ubiquitously expressed adenosine receptors...
  42. Cognition in Rhesus Macaques in Relation to Age and Endocrine Status
    Henryk F Urbanski; Fiscal Year: 2013
    ..that age-related attenuation of circulating T and DHEA levels negatively impacts centrally-mediated physiological processes, including the circadian sleep-wake cycle and cognition...
  43. Blood Pressure Regulation by the Circadian Clock Protein Per1
    Michelle L Gumz; Fiscal Year: 2013
    ..Indeed, many physiological processes exhibit a circadian pattern, including the sleep- wake cycle, heartbeat, hormone secretion, and renal ..
  44. Humanization of hFcRn Mice for Physiological Evaluation of Therapeutic Antibodies
    MICHAEL VAN WILES; Fiscal Year: 2013
    ..To establish models that better reflect the human physiological processes, we propose to exchange the Fc domain of mouse lgG2b with human Fc and to replace the mouse albumin gene ..
    Barry P Sleckman; Fiscal Year: 2012
    ..We now propose to identify histone modifications that function as intermediates to coordinate the normal repair of DNA-DSBs in mammalian cells. ..
  46. Function of Laccases in Anopheles gambiae
    Michael R Kanost; Fiscal Year: 2010
    ..They have been implicated in a variety of physiological processes in plants and fungi, including lignin synthesis and degradation, morphogenesis, pigmentation, ..
  47. 12-HETrE regulation of platelets
    MICHAEL ALLAN HOLINSTAT; Fiscal Year: 2013 begin to understand how 12-LOX oxidation of DGLA can potentially lead to regulation of a number of physiological processes including thrombosis, inflammation, immunity and regulation of tumor growth...
    Jeffrey D Esko; Fiscal Year: 2010
    ..Heparan sulfate proteoglycans participate in a variety of physiological processes by binding, activation or immobilization of various protein ligands...
  49. Leica TCS SP5 Multiphoton Confocal Microscope
    Heather A Drummond; Fiscal Year: 2012
    ..of research projects throughout the campus, each directed to significant disease or health-related physiological processes. The proposed instrument will be used in studies addressing hypertension, diabetes, renal angiogenesis, ..
  50. Rat Models for Sex Steroid Action
    Michael J Soares; Fiscal Year: 2013
    ..The rat is a valuable model for studying physiological processes and is the dominant pre-clinical animal model system used by the pharmaceutical and agro-chemical ..
  51. Estrogen signaling transgenic mouse models
    Richard R Behringer; Fiscal Year: 2011
    ..These receptors are involved in numerous and diverse physiological processes but also pathological conditions, including cancer...
  52. Regulation of Steroidogenic Genes by Trophic Hormones
    Marion B Sewer; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Steroid hormones are key regulators of a diverse array of physiological processes, including sodium homeostasis, reproduction, and the development of secondary sex characteristics...
  53. Molecular mechanisms of potassium channel permeation and gating
    Crina M Nimigean; Fiscal Year: 2013
    ..Potassium (K+) channels are major determinants of cell excitability and play crucial roles in many physiological processes. There are two major mechanistic features of K+ channels: 1) permeation, which comprises both the ..
    Suresh K Joseph; Fiscal Year: 2010
    ..cells generate the complex spatial and temporal patterns in Ca2+ signaling that underlie a multitude of physiological processes as diverse as cell division, cell proliferation, apoptosis, fertilization, development, secretion, smooth ..
  55. Does overexpressing Cu/Zn superoxide dismutase retard aging in rodents
    Arlan G Richardson; Fiscal Year: 2013
    ..low-fat fed mice. In this Specific Aim, we will measure 3 age-sensitive physiological processes to assess the physiological function of the transgenic and WT mice on the low- and high-fat diets: ..
  56. Role of TL1A in Severity of Crohn's Disease Inflammation
    Stephan R Targan; Fiscal Year: 2013
  57. Quantitative Analysis of Chemotactic Motility Cycle of Ameboid Cells
    JUAN CARLOS LASHERAS; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Eukaryotic cell motility is essential for many physiological processes such as embryonic development, tissue renewal, and the function of the immune system...
  58. Mechanisms of Metal Ion Regulation in Human Cells
    Svetlana Lutsenko; Fiscal Year: 2013
    ..connective tissue formation, myelination of neurons, detoxification of radicals, and many other physiological processes. Copper deficiency is deleterious to human growth and development, yet excess copper is toxic...
  59. Hereditary Multiple Exostosis Syndrome: Pathogenesis and Treatment
    MAURIZIO contact PACIFICI; Fiscal Year: 2010
  60. Development of GM-CSF reporter and reporter/fate-reporter mice
    Bogoljub Ciric; Fiscal Year: 2013
    ..GM-CSF is involved in a variety of physiological processes ranging from wound healing and haematopoiesis to placental and fetal development, but it is best known ..
  61. Lipidomic profile of endocannabinoids from neuronal cells
    VINCENT JO DAVISSON; Fiscal Year: 2010
    ..These compounds have neuromodulatory activity and appear to play a role in multiple physiological processes. The two major endocannabinoids identified in the brain are anandamide (N-arachidonyl- ethanolamide) and ..
  62. Circadian Clock of the Paraventricular Nucleus
    Charles J Weitz; Fiscal Year: 2012
    ..The PVN is known to play a vital role in central, endocrine, and autonomic physiological processes, particularly those regulating feeding behavior, energy balance, and glucose homeostasis...
    Gordon Amidon; Fiscal Year: 1993
    ..which, when combined with appropriate results of animal and human experiments on the basic underlying physiological processes, will be predictive of drug absorption in humans...
  64. Mitochondrial Assembly and Dynamics in Health and Disease
    Carla Koehler; Fiscal Year: 2009
    ..Seminal advances have occurred in recent years on physiological processes within the organelle such as the dynamics of morphology, protein import into sub-compartments, ..
  65. Nanoliter Lab-on-a-chip for Protein Crystallization
    Vamsee Pamula; Fiscal Year: 2007
    ..ribosomal proteins, bacterial toxins, hormones, and receptors are essential to understand important physiological processes and also to understand and treat diseases caused by microorganisms...
  66. Enabling Strategies for Growing Collagenous Tissues
    LAURA E contact NIKLASON; Fiscal Year: 2010
    ..In the body, soft connective tissues must withstand the physical forces that are created by physiological processes and by movement in every day life...
  67. Determinants of Word Recognition Speed in Older Listeners
    Frederick J Gallun; Fiscal Year: 2011
    ..The goal of this research is to better understand the psychophysical and physiological processes that limit speech understanding in the elderly...
  68. Sequence Distribution of Tabacco Carcinogen-DNA Adducts
    Natalia Tretyakova; Fiscal Year: 2007
    Endogenous cytosine methylation at 5'-CG-3' sites within the human genome is involved in many physiological processes, including gene expression, host defense, genomic imprinting, and X chromosome inactivation...
    Scott Waldman; Fiscal Year: 2000
    ..applicant notes that receptor guanylyl cyclases are a family of proteins which regulate important (patho)physiological processes, in particular cardiovascular and intestinal fluid and electrolyte homeostasis...
    Athan Kuliopulos; Fiscal Year: 1999
    ..This receptor is a member of a super-family of 7-transmembrane receptors involved in such diverse physiological processes as endocrine signaling, neurotransmission, vision, and blood- clotting...
  71. Fourth International MHE Research Conference
    Maurizio Pacifici; Fiscal Year: 2012
    CARRIE BAGATELL; Fiscal Year: 1992
    ..This knowledge may in turn be useful in developing new treatment options for diseases of the male reproductive system and in developing strategies to decrease coronary risk from lipoprotein abnormalities...
    VALERIE GALTON; Fiscal Year: 2006
    Thyroid hormone (TH) has profound effects on a wide variety of physiological processes in most organ systems, and plays a major role in the maintenance of basal metabolic rate and thermogenesis...
  74. Intrinsic and Extrinsic Effects on Trajectories of Infants' Vagal Functioning
    Cathi Propper; Fiscal Year: 2009
    ..of regulatory behaviors necessary for state, motor, and emotion control may have certain underlying physiological processes in the parasympathetic nervous system that play a role in their functioning...