pharmacology

Summary

Summary: The study of the origin, nature, properties, and actions of drugs and their effects on living organisms.

Top Publications

  1. ncbi Network pharmacology: the next paradigm in drug discovery
    Andrew L Hopkins
    Division of Biological Chemistry and Drug Discovery, College of Life Science, University of Dundee, Dundee, UK
    Nat Chem Biol 4:682-90. 2008
  2. pmc DrugBank: a knowledgebase for drugs, drug actions and drug targets
    David S Wishart
    Department of Computing Science, University of Alberta, Edmonton, AB, Canada T6G 2E8
    Nucleic Acids Res 36:D901-6. 2008
  3. pmc PubChem: a public information system for analyzing bioactivities of small molecules
    Yanli Wang
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
    Nucleic Acids Res 37:W623-33. 2009
  4. ncbi Systems pharmacology to predict drug toxicity: integration across levels of biological organization
    Jane P F Bai
    Office of Clinical Pharmacology, Office of Translational Science, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland 20993, USA
    Annu Rev Pharmacol Toxicol 53:451-73. 2013
  5. ncbi Systems pharmacology: bridging systems biology and pharmacokinetics-pharmacodynamics (PKPD) in drug discovery and development
    Piet H van der Graaf
    Pfizer, Department of Pharmacometrics, Global Clinical Pharmacology, IPC 096, Sandwich, CT13 9NJ, UK
    Pharm Res 28:1460-4. 2011
  6. pmc DrugBank: a comprehensive resource for in silico drug discovery and exploration
    David S Wishart
    Department of Computing Science, University of Alberta, Edmonton, AB, Canada T6G 2E8
    Nucleic Acids Res 34:D668-72. 2006
  7. ncbi International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors
    B B Fredholm
    Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden, The Netherlands
    Pharmacol Rev 53:527-52. 2001
  8. ncbi Molecular networks for the study of TCM pharmacology
    Jing Zhao
    Department of Natural Medicinal Chemistry, Second Military Medical University, PR China
    Brief Bioinform 11:417-30. 2010
  9. ncbi Carbon nanotubes as nanomedicines: from toxicology to pharmacology
    Lara Lacerda
    Nanomedicine Laboratory, Centre for Drug Delivery Research, The School of Pharmacy, University of London 29 39 Brunswick Square WC1N 1AX, United Kingdom
    Adv Drug Deliv Rev 58:1460-70. 2006
  10. ncbi The pharmacology and signaling of bitter, sweet, and umami taste sensing
    R Kyle Palmer
    Redpoint Bio Corporation, 2005 Eastpark Blvd, Cranbury, NJ 08512, USA
    Mol Interv 7:87-98. 2007

Research Grants

  1. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
  2. Transcription factors regulating sensory gene expression and pain pathways
    Eric E Turner; Fiscal Year: 2011
  3. Hypothalamic Orexin Role in Menopause-Associated Hot Flashes and Mood/Sleep Disru
    PHILIP LEE JOHNSON; Fiscal Year: 2013
  4. Phosphorylation of FGF23 coordinates crosstalk between the skeleton and kidney
    VINCENT SCOTT TAGLIABRACCI; Fiscal Year: 2013
  5. FASEB SRC on Lysophospholipd Mediators in Health and Disease
    Julie D Saba; Fiscal Year: 2011
  6. Development of a Nonpsychotropic Cannabinoid Agonist for the Treatment of Sclerod
    Robert B Zurier; Fiscal Year: 2012
  7. CRF-Oxytocin Interaction in the Regulation of Stress and Affect
    Joanna Dabrowska; Fiscal Year: 2013
  8. Preclinical Development of JS-K, a Novel NO-Generating Prodrug for Cancer
    Paul J Shami; Fiscal Year: 2012
  9. Structural and molecular basis of drug-induced IKACh reduction
    SAMI FOUAD NOUJAIM; Fiscal Year: 2012
  10. Structural and molecular basis of drug-induced IKACh reduction
    SAMI FOUAD NOUJAIM; Fiscal Year: 2013

Detail Information

Publications317 found, 100 shown here

  1. ncbi Network pharmacology: the next paradigm in drug discovery
    Andrew L Hopkins
    Division of Biological Chemistry and Drug Discovery, College of Life Science, University of Dundee, Dundee, UK
    Nat Chem Biol 4:682-90. 2008
    ..Advances in these areas are creating the foundation of the next paradigm in drug discovery: network pharmacology.
  2. pmc DrugBank: a knowledgebase for drugs, drug actions and drug targets
    David S Wishart
    Department of Computing Science, University of Alberta, Edmonton, AB, Canada T6G 2E8
    Nucleic Acids Res 36:D901-6. 2008
    ..DrugBank has also significantly improved the power and simplicity of its structure query and text query searches. DrugBank is available at http://www.drugbank.ca...
  3. pmc PubChem: a public information system for analyzing bioactivities of small molecules
    Yanli Wang
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
    Nucleic Acids Res 37:W623-33. 2009
    ..Most of the tools described in this work can be directly accessed at http://pubchem.ncbi.nlm.nih.gov/assay/. URLs for accessing other tools described in this work are specified individually...
  4. ncbi Systems pharmacology to predict drug toxicity: integration across levels of biological organization
    Jane P F Bai
    Office of Clinical Pharmacology, Office of Translational Science, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland 20993, USA
    Annu Rev Pharmacol Toxicol 53:451-73. 2013
    To achieve sensitive and specific mechanism-based prediction of drug toxicity, the tools of systems pharmacology will be integrated using structured ontological approaches, analytics, mathematics, and statistics...
  5. ncbi Systems pharmacology: bridging systems biology and pharmacokinetics-pharmacodynamics (PKPD) in drug discovery and development
    Piet H van der Graaf
    Pfizer, Department of Pharmacometrics, Global Clinical Pharmacology, IPC 096, Sandwich, CT13 9NJ, UK
    Pharm Res 28:1460-4. 2011
    ..This has led to the emergence of systems pharmacology. Broadly speaking, this is the quantitative analysis of the dynamic interactions between drug(s) and a ..
  6. pmc DrugBank: a comprehensive resource for in silico drug discovery and exploration
    David S Wishart
    Department of Computing Science, University of Alberta, Edmonton, AB, Canada T6G 2E8
    Nucleic Acids Res 34:D668-72. 2006
    ..DrugBank is available at http://redpoll.pharmacy.ualberta.ca/drugbank/...
  7. ncbi International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors
    B B Fredholm
    Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden, The Netherlands
    Pharmacol Rev 53:527-52. 2001
    ..Testable models of the interaction of these drugs with their receptors have been generated by site-directed mutagenesis and homology-based modelling. Both agonists and antagonists are being developed as potential drugs...
  8. ncbi Molecular networks for the study of TCM pharmacology
    Jing Zhao
    Department of Natural Medicinal Chemistry, Second Military Medical University, PR China
    Brief Bioinform 11:417-30. 2010
    ..This review introduces available sources and methods that could be utilized for the network-based study of TCM pharmacology, proposes a workflow for network-based TCM pharmacology study, and presents two case studies on applying these ..
  9. ncbi Carbon nanotubes as nanomedicines: from toxicology to pharmacology
    Lara Lacerda
    Nanomedicine Laboratory, Centre for Drug Delivery Research, The School of Pharmacy, University of London 29 39 Brunswick Square WC1N 1AX, United Kingdom
    Adv Drug Deliv Rev 58:1460-70. 2006
    ....
  10. ncbi The pharmacology and signaling of bitter, sweet, and umami taste sensing
    R Kyle Palmer
    Redpoint Bio Corporation, 2005 Eastpark Blvd, Cranbury, NJ 08512, USA
    Mol Interv 7:87-98. 2007
    ..Taste signaling, therefore, should be amenable to the methods of pharmacology. This review focuses on the GPCR-mediated signaling of bitter, sweet, and umami tastes and emphasizes the ..
  11. ncbi A microfluidic pipette for single-cell pharmacology
    Alar Ainla
    Department of Chemical and Biological Engineering, Chalmers University of Technology, Kemivagen 10, SE 412 96 Goteborg, Sweden
    Anal Chem 82:4529-36. 2010
    ..In short, the microfluidic pipette allows for complex, contamination-free multiple-compound delivery for pharmacological screening of intact adherent cells...
  12. ncbi International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. XXXVIII. Update on terms and symbols in quantitative pharmacology
    Richard R Neubig
    Department of Pharmacology, 1301 MSRB III Box 0632, University of Michigan, Ann Arbor, MI 48109 0632, USA
    Pharmacol Rev 55:597-606. 2003
    ..follow have been updated from the proposals of a Technical Subcommittee set up by the International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification (Jenkinson DH, Barnard EA, Hoyer D, Humphrey PPA, ..
  13. ncbi International union of pharmacology. XXII. Nomenclature for chemokine receptors
    P M Murphy
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Pharmacol Rev 52:145-76. 2000
    ..The purpose of this review is to update current concepts of the biology and pharmacology of the chemokine system, to summarize key information about each chemokine receptor, and to describe a widely ..
  14. ncbi Modulating G-protein-coupled receptors: from traditional pharmacology to allosterics
    Annette Gilchrist
    Caden Biosciences, 5500 Nobel Drive, Madison, WI 53711, USA
    Trends Pharmacol Sci 28:431-7. 2007
    ..The implications are far reaching in pharmacology, as it means that a GPCR could have a different pharmacological profile depending on which G protein is ..
  15. pmc Use of natural products as chemical library for drug discovery and network pharmacology
    Jiangyong Gu
    Beijing National Laboratory for Molecular Sciences, State Key Lab of Rare Earth Material Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing, PR China
    PLoS ONE 8:e62839. 2013
    ..Natural products have been an important source of lead compounds for drug discovery. How to find and evaluate bioactive natural products is critical to the achievement of drug/lead discovery from natural products...
  16. pmc Only connect: the merger of BMC Pharmacology and BMC Clinical Pharmacology
    Elizabeth C Moylan
    BioMed Central Ltd, 236 Gray s Inn Road, London, WC1X 8HL, UK
    BMC Pharmacol Toxicol 13:1. 2012
    This editorial celebrates the launch of BMC Pharmacology and Toxicology within the BMC series of journals published by BioMed Central...
  17. pmc Interns' knowledge of clinical pharmacology and therapeutics after undergraduate and on-going internship training in Nigeria: a pilot study
    Kazeem A Oshikoya
    Pharmacology Department, Lagos State University College of Medicine, Ikeja, Lagos, Nigeria
    BMC Med Educ 9:50. 2009
    A sound knowledge of pathophysiology of a disease and clinical pharmacology and therapeutics (CPT) of a drug is required for safe and rational prescribing...
  18. ncbi The role of clock genes in pharmacology
    Georgios K Paschos
    Department of Pharmacology, Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    Annu Rev Pharmacol Toxicol 50:187-214. 2010
    ..In this review, we provide evidence supporting the regulation of drug kinetics and dynamics by the circadian clock. We also use the examples of hypertension and cancer to show current achievements and challenges in chronopharmacology...
  19. ncbi Multidimensional drug profiling by automated microscopy
    Zachary E Perlman
    Institute of Chemistry and Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Science 306:1194-8. 2004
    ..Our methods will be useful for discovering the mechanism and predicting the toxicity of new drugs...
  20. ncbi Allosteric GPCR modulators: taking advantage of permissive receptor pharmacology
    Katie Leach
    Drug Discovery Biology Laboratory, Department of Pharmacology, Monash University, Clayton, Victoria 3800, Australia
    Trends Pharmacol Sci 28:382-9. 2007
    ....
  21. ncbi Hormesis is central to toxicology, pharmacology and risk assessment
    Edward J Calabrese
    Department of Public Health, Environmental Health Sciences Division, University of Massachusetts, Amherst, MA, USA
    Hum Exp Toxicol 29:249-61. 2010
    ..It is expected that as low dose responses come to dominate toxicological research that risk assessment practices will incorporate hormetic concepts in the standard setting process...
  22. ncbi Analysis of drug-induced effect patterns to link structure and side effects of medicines
    Anton F Fliri
    Pfizer Global Research and Development, Eastern Point Road, Groton, Connecticut 06340, USA
    Nat Chem Biol 1:389-97. 2005
    ..The identification of this alignment provides a mechanism for forecasting clinical effect profiles of medicines...
  23. ncbi The pharmacology, neuroanatomy and neurogenetics of one-trial object recognition in rodents
    Ekrem Dere
    Institute of Physiological Psychology, and Center for Biological and Medical Research, Heinrich Heine University of Dusseldorf, Dusseldorf, Germany
    Neurosci Biobehav Rev 31:673-704. 2007
    ....
  24. pmc A simple and robust method for connecting small-molecule drugs using gene-expression signatures
    Shu Dong Zhang
    MRC Toxicology Unit, Hodgkin Building, Lancaster Road, University of Leicester, Leicester, UK
    BMC Bioinformatics 9:258. 2008
    ..Lamb et al first proposed the Connectivity Map [Lamb et al (2006), Science 313, 1929-1935] to make successful connections among small molecules, genes, and diseases using genomic signatures...
  25. ncbi Principles: receptor theory in pharmacology
    Terry Kenakin
    Assay Development Compound Profiling, GlaxoSmithKline Research and Development, 5 Moore Drive, Research Triangle Park, NC 27709, USA
    Trends Pharmacol Sci 25:186-92. 2004
    ....
  26. ncbi Integration not isolation: arguing the case for quantitative and systems pharmacology in drug discovery and development
    Balaji M Agoram
    MedImmune LLC, Granta Park, Cambridge, UK
    Drug Discov Today 16:1031-6. 2011
    Quantitative and systems pharmacology (QSP) is an emerging modelling technique that combines the flexibility of systems biology and tractability of compartmental pharmacokinetic-pharmacodynamic modelling techniques...
  27. ncbi Adaption of team learning to an introductory graduate pharmacology course
    George A Dunaway
    Department of Pharmacology, Southern Illinois University School of Medicine, P O Box 19629, Springfield, Illinois 62794, USA
    Teach Learn Med 17:56-62; discussion 85-8. 2005
    ..Team-learning experiences within a large group setting have a variety of educational applications...
  28. ncbi Population clinical pharmacology of children: modelling covariate effects
    Brian J Anderson
    Department of Anaesthesiology, University of Auckland, Auckland, New Zealand
    Eur J Pediatr 165:819-29. 2006
    ..Population modelling using mixed effects models provides a means to study variability in paediatric drug responses among individuals representative of those in whom the drug will be used clinically...
  29. ncbi Biomarkers in pharmacology and drug discovery
    D C Anderson
    Center for Advanced Drug Research, SRI International, Harrisonburg, VA 22802, USA Electronic address
    Biochem Pharmacol 87:172-88. 2014
    ..Problems including introduction of bias into study designs, data reporting or data analysis are also reviewed. ..
  30. ncbi A brief history of great discoveries in pharmacology: in celebration of the centennial anniversary of the founding of the American Society of Pharmacology and Experimental Therapeutics
    Ronald P Rubin
    The State University of New York at Buffalo, School of Medicine and Biomedical Sciences, 102 Farber Hall, Buffalo, NY 14214 3000, USA
    Pharmacol Rev 59:289-359. 2007
  31. pmc Role of systems pharmacology in understanding drug adverse events
    Seth I Berger
    Department of Pharmacology and Systems Biology Center New York, Mount Sinai School of Medicine, New York, NY, USA
    Wiley Interdiscip Rev Syst Biol Med 3:129-35. 2011
    Systems pharmacology involves the application of systems biology approaches, combining large-scale experimental studies with computational analyses, to the study of drugs, drug targets, and drug effects...
  32. ncbi Sniffing out pharmacology: interactions of drugs with human olfaction
    Jorn Lotsch
    pharmazentrum frankfurt and Center for Drug Research, Development and Safety ZAFES, Institute of Clinical Pharmacology, Goethe University Hospital, D 60590 Frankfurt am Main, Germany
    Trends Pharmacol Sci 33:193-9. 2012
    ..With an established molecular basis and using available tools, the assessment of olfaction in drug development and approval is advised...
  33. ncbi Connecting the dots: applications of network medicine in pharmacology and disease
    A Jacunski
    1 Integrated Program in Cellular, Molecular and Biomedical Studies, Columbia University Medical Center, New York, New York, USA 2 Department of Biomedical Informatics, Columbia University Medical Center, New York, New York, USA 3 Department of Systems Biology, Columbia University Medical Center, New York, New York, USA 4 Department of Medicine, Columbia University Medical Center, New York, New York, USA
    Clin Pharmacol Ther 94:659-69. 2013
    ..experimental data on gene, protein, and metabolic interactions with clinical knowledge of disease and pharmacology in order to extend the understanding of diseases and their treatments...
  34. pmc Predicting new molecular targets for rhein using network pharmacology
    Aihua Zhang
    National TCM Key Lab of Serum Pharmacochemistry, Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin 150040, China
    BMC Syst Biol 6:20. 2012
    ..Currently, network pharmacology has used in identifying potential drug targets to predicting the spread of drug activity and greatly ..
  35. ncbi Allostery in pharmacology: thermodynamics, evolution and design
    Gábor Maksay
    Department of Molecular Pharmacology, Institute of Biomolecular Chemistry, Chemical Research Center, Hungarian Academy of Sciences, P O Box 17, H 1525 Budapest, Hungary
    Prog Biophys Mol Biol 106:463-73. 2011
    This review focuses on basic models of allostery, the ambiguous application of the allosteric term in pharmacology illustrated by receptors, the role of thermodynamics in allosteric mechanisms, evolution and design of allostery...
  36. ncbi 10th annual meeting of the Safety Pharmacology Society: an overview
    Icilio Cavero
    Via dei Bacchettoni, 19B, 55100 Lucca, Italy
    Expert Opin Drug Saf 10:319-33. 2011
    The 10th annual meeting of the Safety Pharmacology (SP) Society covered numerous topics of educational and practical research interest...
  37. ncbi Pharmacology of TMS
    Ulf Ziemann
    Clinic of Neurology, J W Goethe University Frankfurt, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Suppl Clin Neurophysiol 56:226-31. 2003
    ..Increasing numbers of different forms of cortical inhibition are being discovered, such as SICI (GABAA dependent), CSP (GABAB dependent) and SLAI (cholinergic), and it is very likely that more will follow soon...
  38. ncbi Quantitative pharmacology or pharmacokinetic pharmacodynamic integration should be a vital component in integrative pharmacology
    J Gabrielsson
    Discovery DMPK and BAC, AstraZeneca R and D Molndal, S 431 83 Molndal, Sweden
    J Pharmacol Exp Ther 331:767-74. 2009
    ..pharmacologists with regard to why pharmacokinetic-pharmacodynamic (PKPD) integration is essential in basic pharmacology research to improve interpretation of data...
  39. ncbi [Network pharmacology: new opportunity for the modernization of traditional Chinese medicine]
    Zhi Hua Liu
    Center for Computational Biology and Bioinformatics, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
    Yao Xue Xue Bao 47:696-703. 2012
    ..The network pharmacology is a novel subject based on the construction of multi-layer networks of disease-phenotype-gene-drug to predict ..
  40. pmc Concepts and challenges in quantitative pharmacology and model-based drug development
    Liping Zhang
    Bristol Myers Squibb Research and Development, Princeton, New Jersey, USA
    AAPS J 10:552-9. 2008
    ..are defined and distinguished: PK-PD modeling, exposure-response modeling, pharmacometrics, quantitative pharmacology, and MBDD...
  41. ncbi Anticipating drug side effects by comparative pharmacology
    Ricard Garcia-Serna
    Chemotargets SL, Passeig de Circumval lació 8, 08003 Barcelona, Catalonia, Spain
    Expert Opin Drug Metab Toxicol 6:1253-63. 2010
    ..we provide proof that drugs related by side effect similarity have in fact affinities for multiple common targets beyond their primary targets and set the basis for the use of comparative pharmacology to anticipate drug side effects.
  42. ncbi Discovery of novel regulatory peptides by reverse pharmacology: spotlight on chemerin and the RF-amide peptides metastin and QRFP
    Christian Kutzleb
    IPF PharmaCeuticals GmbH, Feodor Lynen Str 31, D 30625 Hannover, Germany
    Curr Protein Pept Sci 6:265-78. 2005
    Reverse pharmacology is a screening technology that matches G protein-coupled receptors (GPCRs) with unknown cognate ligands in cell-based screening assays by detection of agonist-induced signaling pathways...
  43. ncbi Safety and secondary pharmacology: successes, threats, challenges and opportunities
    Jean Pierre Valentin
    Safety Assessment UK, AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire, SK10 4TG, United Kingdom
    J Pharmacol Toxicol Methods 58:77-87. 2008
    This review summarises the lecture of Dr Tim Hammond, recipient of the Distinguished Service Award of the Safety Pharmacology Society, given on 20 September 2007 in Edinburgh...
  44. ncbi Gene expression microarray analysis in cancer biology, pharmacology, and drug development: progress and potential
    P A Clarke
    Cancer Research Campaign Centre for Cancer Therapeutics, E Block, Institute of Cancer Research, 15 Cotswold Road, SM2 5NG, Sutton, Surrey, UK
    Biochem Pharmacol 62:1311-36. 2001
    ..microarray technology and illustrate the progress and potential of the methodology in cancer biology, pharmacology, and drug development...
  45. ncbi Network pharmacology
    Andrew L Hopkins
    Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, United Kingdom
    Nat Biotechnol 25:1110-1. 2007
  46. ncbi Nurses' perceptions of their pharmacology educational needs
    Rachel L King
    Emergency Admissions Unit, Royal Hallamshire Hospital, Sheffield, UK
    J Adv Nurs 45:392-400. 2004
    b>Pharmacology education in nursing has become increasingly important as nurses' roles in administering, prescribing and educating patients about their medications have grown...
  47. ncbi Sorting out astrocyte physiology from pharmacology
    Todd A Fiacco
    Department of Cell Biology and Neuroscience, University of California, Riverside, California 92521, USA
    Annu Rev Pharmacol Toxicol 49:151-74. 2009
    ....
  48. ncbi Metabolomics in the context of systems biology: bridging traditional Chinese medicine and molecular pharmacology
    Mei Wang
    SU Biomedicine, Utrechtsweg 48, P O Box 360, 3700 AJ Zeist, The Netherlands
    Phytother Res 19:173-82. 2005
    ..such as those used in Traditional Chinese Medicine, in complex biological systems; abridging it with molecular pharmacology. This approach is considered to have the potential to revolutionize natural product research and to advance the ..
  49. ncbi Keynote review: in vitro safety pharmacology profiling: an essential tool for successful drug development
    Steven Whitebread
    PreClinical Profiling, Lead Discovery Center, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA
    Drug Discov Today 10:1421-33. 2005
    Broad-scale in vitro pharmacology profiling of new chemical entities during early phases of drug discovery has recently become an essential tool to predict clinical adverse effects...
  50. ncbi Defining the role of pharmacology in the emerging world of translational research
    S J Enna
    Department of Molecular and Integrative Physiology, Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas, USA
    Adv Pharmacol 57:1-30. 2009
    b>Pharmacology is focused on studying the effects of endogenous agents and xenobiotics on tissue and organ function...
  51. ncbi Navigating chemical space for biology and medicine
    Christopher Lipinski
    Pfizer Global R and D, Groton Laboratories, Eastern Point Road, Groton, Connecticut 06340, USA
    Nature 432:855-61. 2004
    ..what are the best strategies for identifying small molecules that modulate biological targets? And how might such strategies differ, depending on whether the primary goal is to understand biological systems or to develop potential drugs?..
  52. ncbi The contribution of pharmacology to research on the mechanisms of memory formation
    J L McGaugh
    Center for the Neurobiology of Learning and Memory, and Research Professor, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 3800, USA
    Trends Pharmacol Sci 21:208-10. 2000
    ..There is now considerable evidence that this hope is justified...
  53. pmc Principles of safety pharmacology
    M K Pugsley
    Department of Toxicology and Pathology, Global Preclinical Development, Johnson and Johnson Pharmaceutical Research and Development, Raritan, NJ, USA
    Br J Pharmacol 154:1382-99. 2008
    Safety Pharmacology is a rapidly developing discipline that uses the basic principles of pharmacology in a regulatory-driven process to generate data to inform risk/benefit assessment...
  54. ncbi Replacing animal use in physiology and pharmacology teaching in selected universities in Eastern Europe--charting a way forward
    David G Dewhurst
    Learning Technology Section, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, UK
    Altern Lab Anim 39:15-22. 2011
    ..There was a consensus view that developing local language exemplars and evaluating their usefulness was likely to have the greatest impact on animal use, at least in the short-term...
  55. ncbi The impact of network biology in pharmacology and toxicology
    G Panagiotou
    Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark
    SAR QSAR Environ Res 23:221-35. 2012
    ....
  56. ncbi Information extraction in the life sciences: perspectives for medicinal chemistry, pharmacology and toxicology
    Marc Zimmermann
    Fraunhofer Institute for Algorithms and Scientific Computing SCAI, Schloss Birlinghoven, D 53754 St Augustin, Germany
    Curr Top Med Chem 5:785-96. 2005
    ..Similar to biology and medical sciences, medicinal chemistry, pharmacology and toxicology are descriptive sciences...
  57. pmc Finding multiple target optimal intervention in disease-related molecular network
    Kun Yang
    Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing, China
    Mol Syst Biol 4:228. 2008
    ..A number of promising MTOI solutions were found to be both effective and safer...
  58. ncbi Engagement of students with lectures in biochemistry and pharmacology
    Elizabeth Ann Davis
    Department of Pharmacology, Monash University, Melbourne, Australia
    Biochem Mol Biol Educ 40:300-9. 2012
    ..attendance of students over two year levels enrolled in two separate science disciplines, biochemistry and pharmacology. The study further sought to determine the factors that influence lecture attendance...
  59. ncbi Comparative pharmacology of GP IIb/IIIa antagonists
    Karsten Schror
    Institut fur Pharmakologie und Klinische Pharmakologie, Heinrich Heine Universitat Dusseldorf, Germany
    J Thromb Thrombolysis 15:71-80. 2003
    ..The inherent problems with all GP IIb/IIIa antagonists are the narrow therapeutic range because the same mechanisms are involved in hemostasis and thrombosis and their inability to inhibit platelet activation...
  60. ncbi Nous sommes tous des bacteries: implications for medicine, pharmacology and public health
    David J Triggle
    State University of New York, Buffalo, NY, USA
    Biochem Pharmacol 84:1543-50. 2012
    ....
  61. ncbi Gastrointestinal-tract models and techniques for use in safety pharmacology
    A P Harrison
    Department of Anatomy and Physiology, The Royal Veterinary and Agricultural University, Grønnegårdsvej 7, DK 1870 Frederiksberg C, Denmark
    J Pharmacol Toxicol Methods 49:187-99. 2004
    ..It is concluded that the field of safety pharmacology could rapidly, cheaply, and routinely incorporate membrane, isolated tissue, and endoscopy techniques for GI ..
  62. ncbi A comparison of student outcomes following problem-based learning instruction versus traditional lecture learning in a graduate pharmacology course
    Sally K Miller
    University of Nevada at Las Vegas, USA
    J Am Acad Nurse Pract 15:550-6. 2003
    To determine if there would be a difference in students' performance and level of satisfaction when taught pharmacology in a problem-based learning format as compared to traditional lecture format.
  63. ncbi Systems pharmacology for drug discovery and development: paradigm shift or flash in the pan?
    P Vicini
    Pharmacokinetics, Dynamics and Metabolism, Pfizer, San Diego, California, USA
    Clin Pharmacol Ther 93:379-81. 2013
    Systems pharmacology is an emerging approach that sets out to use quantitative concepts rooted in the synergy between modeling and simulation on one hand and large-scale data collection and analysis on the other to investigate biological ..
  64. ncbi Pedagogy for teaching and learning cooperatively on the Web: a Web-based pharmacology course
    Mimi M Y Tse
    School of Nursing, Hong Kong Polytechnic University, Kowloon, Hong Kong
    Cyberpsychol Behav 10:32-7. 2007
    ..This article presents the development, utilization and evaluation of a web-based pharmacology course for nursing students. The course was developed based on 150 commonly used drugs...
  65. ncbi Teaching basic and clinical pharmacology to medical students: a 2006 survey in French schools of medicine
    Patrice Jaillon
    Service de Pharmacologie, Hopital Saint Antoine, Assistance Publique Hôpitaux de Paris and Faculté de Médecine Pierre et Marie Curie Site Saint Antoine, Universite Paris 6, Paris, France
    Therapie 61:439-46. 2006
    ..was organized in 2006 in France in order to investigate the status of the core curriculum of basic and clinical pharmacology (BCP) teaching hours (TH) in the 6 years training of medical studies...
  66. ncbi The use of popular movies during lectures to aid the teaching and learning of undergraduate pharmacology
    Sab Ventura
    Monash University, VIC 3052, Australia
    Med Teach 31:662-4. 2009
    ..The role of the lecturer has changed to one where they must engage and motivate students to learn the subject material...
  67. pmc Elusive equilibrium: the challenge of interpreting receptor pharmacology using calcium assays
    Steven J Charlton
    Novartis Institutes for BioMedical Research, Horsham, UK
    Br J Pharmacol 161:1250-65. 2010
    ..calcium assays, paying particular attention to the potential issues associated with interpretation of receptor pharmacology using this system...
  68. pmc Neuroimmune pharmacology as a sub-discipline of medical neuroscience in the medical school curriculum
    Robert W Freilich
    Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA 02118, USA
    J Neuroimmune Pharmacol 6:41-56. 2011
    The emerging field of neuroimmune pharmacology (NIP) is the confluence of three distinct disciplines: neuroscience, immunology, and pharmacology (Gendelman and Ikezu 2008)...
  69. ncbi Drugs, their targets and the nature and number of drug targets
    Peter Imming
    Institut fur Pharmazie, Martin Luther Universitat Halle Wittenberg, 06120 Halle, Germany
    Nat Rev Drug Discov 5:821-34. 2006
    ....
  70. ncbi Computer-based alternatives to using animals in teaching physiology and pharmacology to undergraduate students
    David Dewhurst
    Learning Technology Section, College of Medicine and Veterinary Medicine, University of Edinburgh, Hugh Robson Link Building, 15 George Square, Edinburgh EH8 9XD, UK
    Altern Lab Anim 32:517-20. 2004
    ..UK, the majority of animals used for undergraduate education are for laboratory practical classes (wet labs) in pharmacology and physiology...
  71. ncbi The impact of introducing computer-based alternatives to the use of animals in the teaching of physiology and pharmacology at Balkan universities - a pilot study
    Zvezdana Z Kojic
    Institute of Medical Physiology, School of Medicine, University of Belgrade, Visegradska 26, 11000 Belgrade, Serbia
    Altern Lab Anim 37:547-56. 2009
    Balkan universities use a substantial number of small mammals and amphibians in the teaching of physiology and pharmacology. This project investigated whether making computer-based alternatives readily available, and combining this ..
  72. ncbi Degradable and bioresorbable polymers in surgery and in pharmacology: beliefs and facts
    Michel Vert
    Institute of Biomolecules Max Mousseron, UMR CNRS 5247, Montpellier Cedex 5, France
    J Mater Sci Mater Med 20:437-46. 2009
    ....
  73. pmc Human behavioral pharmacology, past, present, and future: symposium presented at the 50th annual meeting of the Behavioral Pharmacology Society
    Sandra D Comer
    New York State Psychiatric Institute Columbia University, 1051 Riverside Drive, NY 10032, USA
    Behav Pharmacol 21:251-77. 2010
    A symposium held at the 50th annual meeting of the Behavioral Pharmacology Society in May 2007 reviewed progress in the human behavioral pharmacology of drug abuse...
  74. pmc Orphans in the human cytochrome P450 superfamily: approaches to discovering functions and relevance in pharmacology
    F Peter Guengerich
    Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, 638 Robinson Research Building, 2200 Pierce Avenue, Nashville, Tennessee 37232 0146, USA
    Pharmacol Rev 63:684-99. 2011
    ..sciences is that the functions of only a fraction of the genes/proteins are known, and this is also an issue in pharmacology. This review is focused on issues related to the functions of cytochrome P450 (P450) enzymes...
  75. ncbi [Tools for network pharmacology study: network visualization and network analysis]
    Leihong Wu
    Department of Chinese Medicine Science and Engineering, Zhejiang University, Hangzhou 310058, China
    Zhongguo Zhong Yao Za Zhi 36:2923-5. 2011
    Network pharmacology has been one of the academic frontiers of traditional Chinese medicine research...
  76. ncbi Scientific foundations of hormesis. Part 2. Maturation, strengths, limitations, and possible applications in toxicology, pharmacology, and epidemiology
    Karl K Rozman
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas, Medical Center, Kansas City, KS 66160 7417, USA
    Crit Rev Toxicol 33:451-62. 2003
    ..challenges. Therefore, both hormesis and hormoligosis are manifestations of two nonmutational evolutionary principles--homeostasis and optimization...
  77. ncbi Traditional African medicine: theory and pharmacology explored
    D T Okpako
    University of Ibadan, Department of Pharmacology and Therapeutics, PO Box 20334, UI Post Office, Oyo Road, Ibadan, Nigeria
    Trends Pharmacol Sci 20:482-5. 1999
    ..This article summarizes the argument for such a therapy, and suggests that TAM is a distinct system of health care and not a rudimentary form of modern Western medicine...
  78. ncbi Applicability of the principles of developmental pharmacology to the study of environmental toxicants
    D Gail McCarver
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Pediatrics 113:969-72. 2004
    ..Some useful extrapolation can be made from the latter, however. An increased impetus for pediatric pharmacology studies resulted from evidence of shortcomings in algorithmic approaches to dosing and the recognition of ..
  79. pmc Representation of less-developed countries in Pharmacology journals: an online survey of corresponding authors
    Dileep K Rohra
    Department of Pharmacology, Alfaisal University, Riyadh, Kingdom of Saudi Arabia
    BMC Med Res Methodol 11:60. 2011
    ..This online survey was conducted with the primary aim of determining the opinion of corresponding authors of published papers in international Pharmacology journals regarding the difficulties in publications and their possible solutions.
  80. pmc Audience response technology: engaging and empowering non-medical prescribing students in pharmacology learning
    Joanne S Lymn
    School of Nursing, Midwifery and Physiotherapy, University of Nottingham, Queens Medical Centre, Nottingham, UK
    BMC Med Educ 10:73. 2010
    ..It is critical that these students develop a good understanding of pharmacology; however, many students are mature learners with little or no formal biological science knowledge and struggle ..
  81. ncbi PK-PD integration and PK-PD modelling of nonsteroidal anti-inflammatory drugs: principles and applications in veterinary pharmacology
    P Lees
    Royal Veterinary College, Hawkshead Campus, Hatfield, Hertfordshire AL9 7TA, UK
    J Vet Pharmacol Ther 27:491-502. 2004
    ..Using indirect response models and clinically relevant indices, PD data have been determined for flunixin, phenylbutazone and meloxicam in the horse, nimesulide in the dog and meloxicam in the cat...
  82. ncbi Computer-based learning--an aid to successful teaching of pharmacology?
    Ian E Hughes
    School of Biomedical Sciences, University of Leeds, Leeds LS2 9JT, UK
    Naunyn Schmiedebergs Arch Pharmacol 366:77-82. 2002
    Various types of software have been developed for use in pharmacology courses...
  83. ncbi [Application of network pharmacology and high through-put technology on active compounds screening from traditional Chinese medicine]
    Qingshan Liu
    National Center of China for Minority Traditional Medical Research, Minzu University of China, Beijing 100081, China
    Zhongguo Zhong Yao Za Zhi 37:134-7. 2012
    ..To solve the difficult in the active compounds screening from traditional Chinese medicines (TCM)...
  84. ncbi Medicalization of pharmacology teaching: an urgent need in the medical curriculum
    Rodolfo Rodriguez
    Department of Pharmacology, School of Medicine, National University of Mexico UNAM
    Proc West Pharmacol Soc 52:120-8. 2009
    ..population, and knowledge of the literature, we have identified what should constitute the core content of pharmacology courses in medical schools...
  85. ncbi Teaching medical students basic neurotransmitter pharmacology using primary research resources
    Amy C Halliday
    Department of Pharmacology, Oxford University, Oxford, United Kingdom
    Adv Physiol Educ 34:205-12. 2010
    Teaching pharmacology to medical students has long been seen as a challenge, and one to which a number of innovative approaches have been taken...
  86. ncbi Comparison of problem-and lecture-based pharmacology teaching
    Martin C Michel
    Depts of Medicine and Pharmacology, Universitatsklinikum Essen, Hufelandstr 55, 45122, Essen, Germany
    Trends Pharmacol Sci 23:168-70. 2002
    ..Although various approaches have been labelled PBL, it remains unclear which approach is most appropriate for pharmacology courses...
  87. ncbi 2D and 3D cell microarrays in pharmacology
    Xavier Gidrol
    CEA, DSV, iRTSV, Laboratoire Biopuces, 38054 Grenoble Cedex 09, France
    Curr Opin Pharmacol 9:664-8. 2009
    ..This article compares different cell microarray formats and evaluates their potential use in the drug discovery process...
  88. ncbi Ligand-based approaches to in silico pharmacology
    David Vidal
    Chemotargets SL and Chemogenomics Laboratory, Research Unit on Biomedical Informatics, Institut Municipal d Investigació Mèdica and Universitat Pompeu Fabra, Barcelona, Catalonia, Spain
    Methods Mol Biol 672:489-502. 2011
    ..all, methods based on ligand information have emerged as simple, yet highly efficient, approaches to in silico pharmacology. With the recent impact on the identification of new targets for known drugs, they are again the focus of ..
  89. ncbi Professor Chen-Yuan Lee, MD (1915-2001), pharmacologist: snake venom research at the Institute of Pharmacology, National Taiwan University
    Barbara J Hawgood
    Toxicon 40:1065-72. 2002
    Professor Chen-Yuan Lee was born in Tainan, Taiwan. In 1940, he joined the staff of the Institute of Pharmacology of the university, now named National Taiwan University...
  90. ncbi Learning of medical pharmacology via innovation: a personal experience at McMaster and in Asia
    Chiu Yin Kwan
    Department of Medicine, HSC 4N40, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, L8N 3Z5, Canada
    Acta Pharmacol Sin 25:1186-94. 2004
    b>Pharmacology, a discrete preclinical discipline of the traditional medical curriculum, identifies itself distinctly different from the other preclinical or clinical subjects in knowledge base as well as learning/teaching instructions...
  91. ncbi Herrnstein's hyperbolic matching equation and behavioral pharmacology: review and critique
    J Dallery
    Department of Psychology, University of Florida, Gainesville, Florida 32611, USA
    Behav Pharmacol 15:443-59. 2004
    ..Modifications to the equation, known as bias and sensitivity, may explain some of these inconsistent results, and the modified equation may have utility in behavioral pharmacology.
  92. pmc Statistics in pharmacology
    D Spina
    Kings College London, Pharmaceutical Science Research Division, The Sackler Institute of Pulmonary Pharmacology, School of Biomedical and Health Science, Guy s Campus, London, UK
    Br J Pharmacol 152:291-3. 2007
    ..With this in mind, the British Journal of Pharmacology has commissioned a number of review articles to highlight the uses of statistics in experimental design and ..
  93. ncbi Optimising in vivo pharmacology studies--Practical PKPD considerations
    Johan Gabrielsson
    PKPD section, Drug discovery DMPK and BAC, CVGI, AstraZeneca R and D Molndal, S 43183 Mölndal, Sweden
    J Pharmacol Toxicol Methods 61:146-56. 2010
    ..Refined integration of PK and PD (known as 'quantitative pharmacology' or a PKPD approach) is advocated, enabling clarification of the interdependence of a drug's pharmacological ..
  94. ncbi Geriatric pharmacology: safer prescribing for the elderly patient
    Rollin M Wright
    Division of Geriatrics, Department of Medicine, Rhode Island Hospital and Brown Medical School, Providence, RI 02903, USA
    J Am Podiatr Med Assoc 94:90-7. 2004
    ..This article reviews prescribing situations with elderly patients commonly encountered by the podiatric physician. Strategies for medication management are provided to minimize the risk of adverse drug events in the older patient...
  95. ncbi Single molecule techniques for biomedicine and pharmacology
    K O Greulich
    Inst Mol Biotech, Jena Beütenbergstr 11 D07745 Jena, Germany
    Curr Pharm Biotechnol 5:243-59. 2004
    ..Where it is possible, the relevance to pharmacology and biomedicine is emphasized, often as a perspective or suggestion for experiments, since in this young field ..
  96. ncbi Natural products drug discovery: accelerating the clinical candidate development using reverse pharmacology approaches
    Bhushan Patwardhan
    Interdisciplinary School of Health Sciences, University of Pune, Pune 411 007, India
    Indian J Exp Biol 48:220-7. 2010
    ..Approaches based on reverse pharmacology may offer efficient development platforms for herbal formulations...
  97. ncbi Pharmacology
    Mark A Perazella
    Section of Nephrology, Yale University School of Medicine, New Haven, CT 06520 8029, USA
    Am J Kidney Dis 46:1129-39. 2005
  98. ncbi Modified problem-based learning in pharmacology
    R Hudec
    Department of Pharmacology and Clinical Pharmacology, Faculty ofMedicine, Comenius University, Bratislava, Slovakia
    Bratisl Lek Listy 110:732-5. 2009
    ..The aim of this study was to determine differences between PBL as compared to modified PBL with special focus on acquiring EBM principles...
  99. ncbi Tutorial reduces protocol deviations in multicenter ACTG trials with pharmacology endpoints
    Robin DiFrancesco
    Department of Pharmacy Practice, University at Buffalo, Buffalo, New York 14260, USA
    HIV Clin Trials 7:203-9. 2006
    The AIDS Clinical Trials Group (ACTG) pharmacology quality assurance program requires clinical research staff to demonstrate minimum competencies in clinical pharmacology research...
  100. ncbi Model-based drug development: the road to quantitative pharmacology
    Liping Zhang
    Bristol Myers Squibb, Princeton, NJ, USA
    J Pharmacokinet Pharmacodyn 33:369-93. 2006
    ..Quantitative pharmacology is a discipline that learns and confirms the key characteristics of new molecular entities in a quantitative ..

Research Grants69

  1. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
    ..DMP integrates an array of biological and chemical methods, including genetics, pharmacology, and analytical chemistry to identify bona fide physiological enzyme-substrate interactions...
  2. Transcription factors regulating sensory gene expression and pain pathways
    Eric E Turner; Fiscal Year: 2011
    ..that it may be possible to resolve pain pathways into components that can be targeted through their specific pharmacology or molecular biology...
  3. Hypothalamic Orexin Role in Menopause-Associated Hot Flashes and Mood/Sleep Disru
    PHILIP LEE JOHNSON; Fiscal Year: 2013
    ..My training will also involve pharmacology training by Todd Skaar PhD for aim 1;molecular biology coursework and training by William Truitt, PhD, and ..
  4. Phosphorylation of FGF23 coordinates crosstalk between the skeleton and kidney
    VINCENT SCOTT TAGLIABRACCI; Fiscal Year: 2013
    ..Training: The proposed research will be conducted within the department of Pharmacology at the University of California, San Diego (UCSD), under the mentorship of Dr. Jack E. Dixon. Dr...
  5. FASEB SRC on Lysophospholipd Mediators in Health and Disease
    Julie D Saba; Fiscal Year: 2011
    ..to present and discuss novel findings regarding lysophospholipid metabolism, signaling, regulation, pharmacology and clinical trials;2) to facilitate participation of early career investigators;3) to promote participation of ..
  6. Development of a Nonpsychotropic Cannabinoid Agonist for the Treatment of Sclerod
    Robert B Zurier; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: JB Therapeutics has assembled an exceptional scientific team to study the pharmacology and mechanism of action of its novel non-psychotropic cannabinod in the treatment of scleroderma...
  7. CRF-Oxytocin Interaction in the Regulation of Stress and Affect
    Joanna Dabrowska; Fiscal Year: 2013
    ..a world-renowned expert in the neurobiology of oxytocin and social behavior, will provide training in the pharmacology of oxytocin and the oxytocin receptor, and he will guide me in the research pertaining to the oxytocin side of ..
  8. Preclinical Development of JS-K, a Novel NO-Generating Prodrug for Cancer
    Paul J Shami; Fiscal Year: 2012
    ..Upon completion of this project, JSKT will have all the essential pharmacology, toxicology and manufacturing information to submit a successful IND to begin Phase I safety trials of micelle ..
  9. Structural and molecular basis of drug-induced IKACh reduction
    SAMI FOUAD NOUJAIM; Fiscal Year: 2012
    ..I obtained my PhD from the Department of Pharmacology at SUNY Syracuse in 2007...
  10. Structural and molecular basis of drug-induced IKACh reduction
    SAMI FOUAD NOUJAIM; Fiscal Year: 2013
    ..I obtained my PhD from the Department of Pharmacology at SUNY Syracuse in 2007...
  11. Inhibition of IkK to treat lethal Graft-vs.-Host Disease
    Patrick Flood; Fiscal Year: 2009
    ..at Theralogics who are experts on the biology of NF- ?B in Drs Baldwin and Ghosh and two outside experts in the pharmacology of targeted therapy in Dr. William Zamboni and dog models of GVHD in Dr. Richard Nash...
  12. Targeting superbugs: discovery and development of new broad-spectrum lipopeptides
    Jian Li; Fiscal Year: 2013
    ..toxicology studies in rats and non-rodent species, and ultimately IND-enabling GLP toxicology and safety pharmacology studies...
  13. Oklahoma Autoimmunity Center of Excellence
    Judith A James; Fiscal Year: 2013
    ..The Clinical Pharmacology program at OMRF will serve as the primary home for the SLE, RA, Sj"gren's syndrome and TTP clinics...
  14. Mitochondrial dysfunction, oxidative stress, and surgical acute kidney injury
    FREDERIC TREMAINE BILLINGS; Fiscal Year: 2013
    ..University Medical Center operating rooms, intensive care units, and clinics, and in Division of Clinical Pharmacology laboratories...
  15. Enzymatic Regulation of S-Glutathionylation : Role in Apoptosis and Disease
    John J Mieyal; Fiscal Year: 2012
    ..This project is designed from a "bedside to bench" perspective of translational pharmacology, whereby a drug in common use is re-examined from a new vantage point to seek therapeutic improvement...
  16. Interdisciplinary Research Training in Reproduction for Indian Fellows
    John C Herr; Fiscal Year: 2010
    ..purposes to improve writing and communication skills, recombinant DMA technology, structural genomics, pharmacology, bioethics, and drug discovery, design, synthesis, and selection...
  17. Alzheimer's Disease Therapeutic
    Trevor P Castor; Fiscal Year: 2012
    ..effort, we will conduct IND-enabling preclinical in vivo studies, including toxicology, efficacy, pharmacology and stability testing of selected formulation of bryostatin 1 drug product under Good Laboratory Practices (GLP)..
  18. Targeting CC-Chemokine Receptor 7 for the prevention of graft-versus-host disease
    JAMES M COGHILL; Fiscal Year: 2013
    ..A formalized didactic curriculum is also proposed, including coursework in pharmacology, cell biology, grantsmanship, and the responsible conduct of research. Through these experiences, Dr...
  19. Estrogen Modulation of Auditory Processing
    Raphael Pinaud; Fiscal Year: 2012
    ..Second, a combination of intracerebral pharmacology in awake birds and biochemical methods will determine the specific intracellular mechanisms by which E2 ..
  20. Neurotrophins in the Lung
    Y S Prakash; Fiscal Year: 2012
    ..Using biochemistry, pharmacology, molecular biology, immunocytochemistry, fluorescence Ca2+ imaging, force measurement techniques, and lung ..
  21. Novel SCID rat models for human cell transplantation studies
    Joseph C Ruiz; Fiscal Year: 2010
    ..In addition, the rat has been a valuable animal model for physiology, behavior, and pharmacology research programs, due to ease of experimental manipulation...
  22. VISUAL SCIENCES TRAINING PROGRAM
    Eric Pearlman; Fiscal Year: 2013
    ..Molecular Biology &Microbiology, Neurosciences, Ophthalmology &Visual Sciences, Pathology and Pharmacology. Expansion of capabilities and productivity in the field of vision research has led to its selection as a ..
  23. Targeting p53-Dependent Repigmentation in Vitiligo
    TAMARA G TERZIAN; Fiscal Year: 2013
    ..Terzian will attend courses in immunology, dermatology and dermatopathology, pharmacology, biostatistics and ethics. These courses will assist Dr...
  24. Treatment of Inflammatory Bowel Disease with Ceramidase Inhibitors
    Lynn W Maines; Fiscal Year: 2012
    ..In this Phase 1 SBIR project, we will evaluate the pharmacology and anti-IBD activity of three novel ceramidase inhibitors (representing three chemotypes of ceramidase ..
  25. EXPRESSION PROFILES FOR RET-POSITIVE DRG NEURONS
    Sanjay Jain; Fiscal Year: 2013
    ..There is extensive heterogeneity in DRG at several levels including neurochemistry, pharmacology, morphology, and molecular profiles...
  26. Integrin Regulation of Stretch-Activated Myometrial Signaling During Pregnancy an
    Heather R Burkin; Fiscal Year: 2012
    ..An appointment in the Pharmacology Department here at the medical school would ideally situate me to identify pharmacological agents to halt ..
  27. Integrin Regulation of Stretch-Activated Myometrial Signaling During Pregnancy an
    Heather R Burkin; Fiscal Year: 2013
    ..An appointment in the Pharmacology Department here at the medical school would ideally situate me to identify pharmacological agents to halt ..
  28. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    Quentin J Baca; Fiscal Year: 2010
    ..productive 20 year career on the Harvard faculty where he is a Professor of Biological Chemistry and Molecular Pharmacology. His publications in the area of protein and lipid mobility in cell membranes have appeared in high profile ..
  29. The unique role of B-Raf in murine cardiac development and postnatal function
    Natasha N Chattergoon; Fiscal Year: 2013
    ..I completed my M.S. and Ph.D. degrees at Tulane University in the Department of Pharmacology in August 2000 and August 2004, respectively...
  30. Use of Phosphodiesterase Inhibitors to Evaluate the Pathobiology of CF
    JENNIFER L TAYLOR-COUSAR; Fiscal Year: 2013
    ..of expertise in the design of clinical trials through formal training in statistical methods and analysis and pharmacology, establishment of a mentoring team to obtain guidance from senior investigators with experience in the design ..
  31. Design and Synthesis of Anxioselective Anxiolytics
    James M Cook; Fiscal Year: 2010
    ..A network of 12 collaborators has been established to work with us on receptor binding, efficacy and pharmacology to understand the fundamental basis of/and treat anxiety disorders, as well as memory-impairment including age ..
  32. Roles of RhoA/Rho-kinase Signaling in Cavernous Neurons Following Axonal Injury
    TRINITY JUDE BIVALACQUA; Fiscal Year: 2013
    ..I obtained my MD/PhD from Tulane University in Molecular Pharmacology. My PhD thesis focused on the influence of systemic disease states such as diabetes on endothelial cell biology,..
  33. Long-Acting G-CSF Analog for Treating ARS
    GEORGE NORBERT COX; Fiscal Year: 2013
    ..we will measure the safety profile and pharmacokinetic properties of the protein in IND-enabling, GLP animal pharmacology and toxicology studies in order to identify safe doses of the drug for testing in humans...
  34. Serotonin transporter-mediated regulation of neuroendocrine exocytosis
    KEVIN P CURRIE; Fiscal Year: 2013
    ..Our preliminary data show that chromaffin cells accumulate 5HT through uptake by SERT. Our data using pharmacology (SSRIs) and transgenic mice (knock-out and knock-in models of SERT) also support a role for SERT in the ..
  35. Research Training in Cardiovascular and Pulmonary Diseases
    S Jamal Mustafa; Fiscal Year: 2012
    ..Faculty advisors are investigators trained in various disciplines including: Physiology, Pharmacology, Biochemistry, Cell Biology, Neurobiology, Microbiology, Immunology, Exercise Science, Genetics, Molecular ..
  36. PROBES FOR CYTOMETRY
    Zbigniew Darzynkiewicz; Fiscal Year: 2013
    ..The assays we propose to develop will find wide application in many diverse fields including pharmacology, mutagenesis, carcinogenesis, toxicology, experimental and clinical oncology as well as in cell and molecular ..
  37. Intravenous Protein Therapy for Myotonic Dystrophy Type 1
    Richard Weisbart; Fiscal Year: 2010
    ..The final product concept will undergo further efficacy, pharmacology and toxicology studies, scaled-up GLP production, additional pre- IND pharmacology and toxicology studies, and ..
  38. Effect of exposure to organochlorine compounds on the development of obesity and
    GEORGE E HOWELL; Fiscal Year: 2011
    ..Howell to make a transition from his basic pharmacology background to the field of environmental toxicology. Dr...
  39. GM-CSF analogs for treating acute radiation syndrome
    GEORGE NORBERT COX; Fiscal Year: 2010
    ..and measure the safety profile and pharmacokinetic properties of the protein in IND- enabling, GLP animal pharmacology and toxicology studies, which are required by the FDA prior to testing the compound in humans...
  40. Organismal Radioprotection Through Pharmacological Quiescence
    JOHN S CHANT; Fiscal Year: 2010
    ..In aim 2, we will perform extensive characterization in rodents of the pharmacology and toxicology of the most promising CDK inhibitors identified in aim 1...
  41. Development of a Novel PolC Inhibitor as a Gram-Positive Antibiotic
    THALE CROSS JARVIS; Fiscal Year: 2013
    ..In Aim 3, a 5-10 kg GLP-toxicology batch will be synthesized, and GLP-compliant toxicology and safety pharmacology studies will be performed...
  42. Multi-Organ Autonomic Electrophysiology in Parkinson Disease
    Samay Jain; Fiscal Year: 2013
    ..strategies of geriatric clinical research to recruit and retain an elderly cohort;(4) Develop expertise in pharmacology as it relates to autonomic function and PD;(5) Apply biostatistics for hypothesis testing of longitudinal and ..
  43. NICHD Maternal Fetal Medicine Units Network
    Geeta K Swamy; Fiscal Year: 2013
    ..campus including pediatrics, anesthesia, infectious diseases, cardiology, hematology, pathology, genetics, pharmacology, epidemiology, research pharmacies and the Duke Translational Medicine Institute (NIH Clinical &..
  44. Development of Bioactive Chemical Probes for Calcium-activated Chloride Channel
    Min Li; Fiscal Year: 2012
    ..These active compounds, with further efforts in pharmacology and medicinal chemistry, may be exploited either as tools or as lead compounds for developing therapeutic ..
  45. Creation of hyperactive transposons for mutagenesis in rodents
    Eric M Ostertag; Fiscal Year: 2011
    ..share more similarity in their cytochrome P450 genes, making the rat a more useful model for toxicology and pharmacology studies...
  46. Research Center for Pharmacology &Drug Toxicology
    L Jackson Roberts; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The Research Center for Pharmacology and Drug Toxicology brings together a group of highly experienced investigators with a shared interest in the role of oxygenation of lipids and oxidative stress in ..
  47. Genetic Determinants of the Response to Thienopyridine Therapy
    Jessica L Mega; Fiscal Year: 2013
    ..Marc Sabatine with the TIMI Study Group) and a multi-disciplinary advisory committee of experts in genetics, pharmacology, platelet biology, and cardiovascular clinical trials. Dr...
  48. Bifunctional Redox Catalyst &Organic Nitrate for Limb Reperfusion
    ANDREW LURIE SALZMAN; Fiscal Year: 2013
    ..manufacture >99% pure CM in to support large animal efficacy studies and follow-on GLP toxicology and safety pharmacology investigations...
  49. Pharmacology of Antiretroviral Nanoparticle Micelles
    Christopher J Destache; Fiscal Year: 2010
    ..PUBLIC HELATH RELEVANCE: This application will investigate the pharmacology of combination antiretrovirals (ritonavir, lopinavir, and efavirenz) fabricated into nanoparticles both in cell ..
  50. Pharmacology of Risperidone Effects on Bone Remodeling and Energy Metabolism
    Karen L Houseknecht; Fiscal Year: 2013
    ..The pharmacology of SGAs is complex: they potently antagonize multiple G protein coupled receptors (GPCRs) including dopamine, ..
  51. A Functional Role for the Circadian Clock Protein Per1 in the Regulation of ??ENa
    Michelle L Gumz; Fiscal Year: 2013
    ..Segal, Julie Johnson, Barbara Battelle and Douglas Eaton are experts in the fields of nephrology, physiology, pharmacology, and neuroscience...
  52. Novel Small Molecules For Acute Liver Failure
    Prakash Narayan; Fiscal Year: 2009
    ..a formal and comprehensive set of regulatory studies profiling the genotoxicology, toxicology and safety pharmacology of Ang 1170 is underway...
  53. Decompressive craniotomy versus medical therapy for refractory intracranial hyper
    Raminder Nirula; Fiscal Year: 2010
    ..Area (05) Comparative Effectiveness Research and specific Challenge Topic, 05-GM-101: Anesthesiology Clinical Pharmacology Sepsis Trauma, Burn, and Peri-operative Injury Wound Healing...
  54. Transscleral Transport & Polymeric Delivery of Antibody & Steroids for Macular Ed
    Ashim K Mitra; Fiscal Year: 2010
    ..e., aqueous solubility, octanol/water partition coefficient, buffer stability and biochemical pharmacology (bioreversion and metabolism) of these compounds in ocular fluids and tissue homogenates including retina/..
  55. Immediate and Delayed Effects of Morphine on Brain Circuits: Animal and Human Cor
    Dusica Bajic; Fiscal Year: 2013
    ..Candidate. I received my MD at the Medical School of Belgrade, Serbia in 1994, and my PhD in Pharmacology at the University of Illinois at Chicago in 2000...
  56. RESEARCH CENTER FOR PHARMACOLOGY AND DRUG TOXICOLOGY
    L Jackson Roberts; Fiscal Year: 2010
    The Research Center for Pharmacology and Drug Toxicology: Novel Mechanisms and Pharmacological Consequences of Polyunsaturated Fatty Acid Oxygenation brings together a tightly-knit group of experienced investigators with a shared interest ..
  57. Protein Phosphatase Regulation of the Principal Renal Sodium Transporter NHE3
    Ion Alexandru Bobulescu; Fiscal Year: 2013
    ..Dr. Bobulescu will train primarily in the laboratory of Dr. Marc Mumby in the Department of Pharmacology, including over 2,000 sq ft of total laboratory space, well equipped with all necessary items needed to carry ..
  58. Bifunctional Redox Agent for the Treatment of PPHN
    GARRY JOHN SOUTHAN; Fiscal Year: 2011
    ..Phase II Specific Aim: Establish the subacute safety and tolerance of IV R-100 in GLP toxicology and safety pharmacology studies...
  59. The differential regulation of poly(ADP-ribose) in cancer and its role in protein
    KRISTIN ANNE KRUKENBERG; Fiscal Year: 2013
    ..in cell-based assays including microscopy, genomics, proteomics, and bioinformatics as well as in cancer pharmacology and the application of basic science to translational research. In pursuit of her goals, Dr...
  60. Cholinergic Receptors as Targets for Accelerated Anthelmintic Discovery
    MICHAEL JOHN KIMBER; Fiscal Year: 2013
    ..The experiments will combine bioimaging techniques, RNA interference (RNAi), bioassays, physiology and pharmacology to determine which of these receptors will progress to the next phase of the project at PAH...
  61. CB1 Receptor Regulation by Cannabinoid Receptor Interacting Protein CRIP1a
    DANA E contact SELLEY; Fiscal Year: 2010
    ..knockout mouse line as a novel tool to investigate effects of CRIP1a on physiological function, behavior and CB pharmacology in vivo...
  62. 18F-beta-Endorphin Imaging: Translational Study of an Opioid Peptide Radiotracer
    BRIAN contact REED; Fiscal Year: 2010
    ..involving the expertise of the co-PIs in peptide chemistry, analytical chemistry, and in vivo opioid receptor pharmacology in non-human primates, as well as guidance and collaboration in radiochemical synthesis, PET imaging, and its ..
  63. Development of Pharmacotherapies for Nicotine Addiction
    Frank Carroll; Fiscal Year: 2009
    ..have extensive experience in organic and medicinal chemistry, molecular pharmacology, animal behavioral pharmacology, and drug abuse research...
  64. MEHARRY CLINICAL RESEARCH CENTER
    Valerie Rice; Fiscal Year: 2009
    ..clinical research activities in the CRC by developing initiatives in oral health, community health, clinical pharmacology, and a collaborative clinical research network;2) to increase the type and quality of direct research support ..
  65. PHARMACOLOGY OF ANTICANCER DRUGS IN ADVANCED AGE
    HEINZ LENZ; Fiscal Year: 2003
    ..which is also characterized by the highest overall incidence of cancer, little is known about the detailed pharmacology of cytotoxic agents in this population group...
  66. The Role of P-glycoprotein in Sitagliptin Clinical Pharmacology
    Christina L Aquilante; Fiscal Year: 2010
    ..As a new oral antidiabetic agent, numerous unanswered questions exist regarding the clinical pharmacology of this drug...
  67. Pharmacology and Toxicology for Neurotherapeutics Program (PTNP)
    Patricia Noker; Fiscal Year: 2011
    ..The Pharmacology and Toxicology for Neurotherapeutics Program (PTNP) contract award will support all preclinical pharmacology ..
  68. NETWORK OF PEDIATRIC PHARMACOLOGY RESEARCH UNITS
    Russell Chesney; Fiscal Year: 2003
    This application seeks to continue the Pediatric Pharmacology Research Unit at The University of Tennessee, Memphis...