nucleic acid sequence homology


Summary: The sequential correspondence of nucleotides in one nucleic acid molecule with those of another nucleic acid molecule. Sequence homology is an indication of the genetic relatedness of different organisms and gene function.

Top Publications

  1. pmc The human genome browser at UCSC
    W James Kent
    Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Cruz, CA 95064, USA
    Genome Res 12:996-1006. 2002
  2. ncbi Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans
    B Wightman
    Department of Molecular Biology, Massachusetts General Hospital, Boston 02114
    Cell 75:855-62. 1993
  3. ncbi The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
    R C Lee
    Harvard University, Department of Cellular and Developmental Biology, Cambridge, Massachusetts 02138
    Cell 75:843-54. 1993
  4. ncbi Adaptive protein evolution at the Adh locus in Drosophila
    J H McDonald
    Department of Ecology and Evolutionary Biology, Princeton University, New Jersey 08544
    Nature 351:652-4. 1991
  5. ncbi Prediction of mammalian microRNA targets
    Benjamin P Lewis
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 115:787-98. 2003
  6. ncbi Direct RNA motif definition and identification from multiple sequence alignments using secondary structure profiles
    D Gautheret
    Centre d immunologie de Marseille Luminy, CNRS UMR 6102 INSERM U 136, Luminy Case 906, 13288 Marseille Cedex 09, France
    J Mol Biol 313:1003-11. 2001
  7. ncbi Identification and characterization of new plant microRNAs using EST analysis
    Bao Hong Zhang
    The Institute of Environmental and Human Health, and Department of Environmental Toxicology, Texas Tech University, Lubbock, TX 79409 1163, USA
    Cell Res 15:336-60. 2005
  8. ncbi A draft sequence of the rice genome (Oryza sativa L. ssp. japonica)
    Stephen A Goff
    Torrey Mesa Research Institute, Syngenta, 3115 Merryfield Row, San Diego, CA 92121, USA
    Science 296:92-100. 2002
  9. ncbi Human l1 retrotransposition is associated with genetic instability in vivo
    David E Symer
    Department of Molecular Biology and Genetics, John Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cell 110:327-38. 2002
  10. ncbi RDP2: recombination detection and analysis from sequence alignments
    D P Martin
    Institute of Infectious Diseases and Molecular Medicine, University of Cape Town Cape Town 7000, South Africa
    Bioinformatics 21:260-2. 2005

Detail Information

Publications332 found, 100 shown here

  1. pmc The human genome browser at UCSC
    W James Kent
    Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Cruz, CA 95064, USA
    Genome Res 12:996-1006. 2002
    ..The conceptual and technical framework of the browser, its underlying MYSQL database, and overall use are described. The web site currently serves over 50,000 pages per day to over 3000 different users...
  2. ncbi Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans
    B Wightman
    Department of Molecular Biology, Massachusetts General Hospital, Boston 02114
    Cell 75:855-62. 1993
    ..These data suggest a molecular mechanism for Lin-14p temporal gradient formation: the lin-4 RNAs base pair to sites in the lin-14 3'UTR to form multiple RNA duplexes that down-regulate lin-14 translation...
  3. ncbi The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
    R C Lee
    Harvard University, Department of Cellular and Developmental Biology, Cambridge, Massachusetts 02138
    Cell 75:843-54. 1993
    ..elegans and found to contain sequences complementary to a repeated sequence element in the 3' untranslated region (UTR) of lin-14 mRNA, suggesting that lin-4 regulates lin-14 translation via an antisense RNA-RNA interaction...
  4. ncbi Adaptive protein evolution at the Adh locus in Drosophila
    J H McDonald
    Department of Ecology and Evolutionary Biology, Princeton University, New Jersey 08544
    Nature 351:652-4. 1991
    ..We suggest that these excess replacement substitutions result from adaptive fixation of selectively advantageous mutations...
  5. ncbi Prediction of mammalian microRNA targets
    Benjamin P Lewis
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 115:787-98. 2003
    ..The predicted regulatory targets of mammalian miRNAs were enriched for genes involved in transcriptional regulation but also encompassed an unexpectedly broad range of other functions...
  6. ncbi Direct RNA motif definition and identification from multiple sequence alignments using secondary structure profiles
    D Gautheret
    Centre d immunologie de Marseille Luminy, CNRS UMR 6102 INSERM U 136, Luminy Case 906, 13288 Marseille Cedex 09, France
    J Mol Biol 313:1003-11. 2001
    ..Furthermore, since the translation of alignments into profiles is straightforward with ERPIN, iterative searches can easily be conducted to enrich collections of homologous RNAs...
  7. ncbi Identification and characterization of new plant microRNAs using EST analysis
    Bao Hong Zhang
    The Institute of Environmental and Human Health, and Department of Environmental Toxicology, Texas Tech University, Lubbock, TX 79409 1163, USA
    Cell Res 15:336-60. 2005
    ..Environmental stresses and developmental switching may be the signals for synthesis and regulation of miRNAs in plants. A model for miRNA induction and expression, and gene regulation by miRNA is hypothesized...
  8. ncbi A draft sequence of the rice genome (Oryza sativa L. ssp. japonica)
    Stephen A Goff
    Torrey Mesa Research Institute, Syngenta, 3115 Merryfield Row, San Diego, CA 92121, USA
    Science 296:92-100. 2002
    ..Assignment of candidate rice orthologs to Arabidopsis genes is possible in many cases. The rice genome sequence provides a foundation for the improvement of cereals, our most important crops...
  9. ncbi Human l1 retrotransposition is associated with genetic instability in vivo
    David E Symer
    Department of Molecular Biology and Genetics, John Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cell 110:327-38. 2002
    ..In a striking number of integrants, short identical sequences were shared between the donor and the target site's 3' end, suggesting a mechanistic model that helps explain the structure of L1 insertions...
  10. ncbi RDP2: recombination detection and analysis from sequence alignments
    D P Martin
    Institute of Infectious Diseases and Molecular Medicine, University of Cape Town Cape Town 7000, South Africa
    Bioinformatics 21:260-2. 2005
  11. pmc Regulation of flowering time and floral organ identity by a MicroRNA and its APETALA2-like target genes
    Milo J Aukerman
    E I duPont de Nemours and Company, Agriculture and Nutrition, Newark, Delaware 19711, USA
    Plant Cell 15:2730-41. 2003
    ..Gain-of-function and loss-of-function analyses indicate that two of the AP2-like target genes normally act as floral repressors, supporting the notion that miR172 regulates flowering time by downregulating AP2-like target genes...
  12. ncbi Prediction of plant microRNA targets
    Matthew W Rhoades
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, MA 02142, USA
    Cell 110:513-20. 2002
    ..The targeting of developmental transcription factors suggests that many plant miRNAs function during cellular differentiation to clear key regulatory transcripts from daughter cell lineages...
  13. pmc High-throughput sequencing of Arabidopsis microRNAs: evidence for frequent birth and death of MIRNA genes
    Noah Fahlgren
    Center for Genome Research and Biocomputing, Department of Botany and Plant Pathology, Oregon State University, Corvallis, Oregon, United States of America
    PLoS ONE 2:e219. 2007
    ..We suggest that MIRNA genes are undergoing relatively frequent birth and death, with only a subset being stabilized by integration into regulatory networks...
  14. ncbi Double-stranded RNA-mediated silencing of genomic tandem repeats and transposable elements in the D. melanogaster germline
    A A Aravin
    Department of Animal Molecular Genetics, Institute of Molecular Genetics, 123182, Moscow, Russia
    Curr Biol 11:1017-27. 2001
    ..The analysis of Caenorhabditis elegans mutants impaired with dsRNA-mediated silencing and studies in plants implicate a biological role of dsRNA-mediated silencing as a transposon-repression and antiviral mechanism...
  15. pmc Genetic steps of mammalian homologous repair with distinct mutagenic consequences
    Jeremy M Stark
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    Mol Cell Biol 24:9305-16. 2004
    ..These results imply that the proper genetic interplay of repair factors is essential to limit the mutagenic potential of DSB repair...
  16. pmc A mammalian microRNA expression atlas based on small RNA library sequencing
    Pablo Landgraf
    Howard Hughes Medical Institute, Laboratory of RNA Molecular Biology, Box 186, The Rockefeller University, New York, NY 10021, USA
    Cell 129:1401-14. 2007
    ..We also propose a subclassification scheme for miRNAs for assisting future experimental and computational functional analyses...
  17. ncbi Unique archaeal assemblages in the Arctic Ocean unveiled by massively parallel tag sequencing
    Pierre E Galand
    Limnology Unit, Department of Continental Ecology, Centre d Estudis Avançats de Blanes CSIC, Blanes, Spain
    ISME J 3:860-9. 2009
    ..Our results unveiled for the first time an archaeal community dominated by group III Euryarchaeota and show biogeographical traits for marine Arctic Archaea...
  18. ncbi The heterochronic maize mutant Corngrass1 results from overexpression of a tandem microRNA
    George Chuck
    Plant Gene Expression Center, 800 Buchanan St, Albany, California 94710, USA
    Nat Genet 39:544-9. 2007
    ..By altering the relative levels of both microRNAs, it is possible to either prolong or shorten juvenile development in maize, thus providing a mechanism for how species-level heterochronic changes can occur in nature...
  19. ncbi Disruption of the APC gene by a retrotransposal insertion of L1 sequence in a colon cancer
    Y Miki
    Department of Biochemistry, Cancer Institute, Tokyo, Japan
    Cancer Res 52:643-5. 1992
    ..This is the first report of the disruption of a tumor suppressor gene caused by somatic insertion of a mobile genetic element...
  20. ncbi Global identification of human transcribed sequences with genome tiling arrays
    Paul Bertone
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520 8103, USA
    Science 306:2242-6. 2004
    ..A large fraction of these are located in intergenic regions distal from previously annotated genes and exhibit significant homology to other mammalian proteins...
  21. pmc Tourist: a large family of small inverted repeat elements frequently associated with maize genes
    T E Bureau
    Botany Department, University of Georgia, Athens 30602
    Plant Cell 4:1283-94. 1992
    ..Taken together, our data suggest that Tourist may be the maize equivalent of the human Alu family of elements with respect to copy number, genomic dispersion, and the high frequency of association with genes...
  22. ncbi RNA secondary structure prediction using stochastic context-free grammars and evolutionary history
    B Knudsen
    Department of Genetics and Ecology, The Institute of Biological Sciences, University of Aarhus, Building 550, Ny Munkegade, 8000 Aarhus C, Denmark
    Bioinformatics 15:446-54. 1999
    ..The method reported here is based on stochastic context-free grammars (SCFGs) to give a prior probability distribution of structures...
  23. pmc The DNA sequence of the human X chromosome
    Mark T Ross
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Nature 434:325-37. 2005
    ..Of this number, 168 have been explained by mutations in 113 X-linked genes, which in many cases were characterized with the aid of the DNA sequence...
  24. pmc Mulan: multiple-sequence local alignment and visualization for studying function and evolution
    Ivan Ovcharenko
    Energy, Environment, Biology and Institutional Computing, Lawrence Livermore National Laboratory, Livermore, California 94550, USA
    Genome Res 15:184-94. 2005
    ..Source code for the aligners and the aligner-evaluation software can be freely downloaded from
  25. ncbi GMAP: a genomic mapping and alignment program for mRNA and EST sequences
    Thomas D Wu
    Department of Bioinformatics Genentech, Inc, South San Francisco, CA 94080, USA
    Bioinformatics 21:1859-75. 2005
  26. pmc The wp mutation of Glycine max carries a gene-fragment-rich transposon of the CACTA superfamily
    Gracia Zabala
    Department of Crop Sciences, University of Illinois, Urbana, IL 61801, USA
    Plant Cell 17:2619-32. 2005
  27. ncbi The draft genome of Ciona intestinalis: insights into chordate and vertebrate origins
    Paramvir Dehal
    U S Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA
    Science 298:2157-67. 2002
    ..The ascidian genome has also acquired a number of lineage-specific innovations, including a group of genes engaged in cellulose metabolism that are related to those in bacteria and fungi...
  28. pmc Antiquity of microRNAs and their targets in land plants
    Michael J Axtell
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Plant Cell 17:1658-73. 2005
    ..Therefore, several individual miRNA regulatory circuits have ancient origins and have remained intact throughout the evolution and diversification of plants...
  29. ncbi CMfinder--a covariance model based RNA motif finding algorithm
    Zizhen Yao
    Department of Computer Science and Engineering, University of Washington, Seattle, WA 98195 2350, USA
    Bioinformatics 22:445-52. 2006
    ..Previous tools fall short of this goal...
  30. ncbi DAGchainer: a tool for mining segmental genome duplications and synteny
    Brian J Haas
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Bioinformatics 20:3643-6. 2004
    ..Automated mining of the Arabidopsis genome for segmental duplications illustrates the use of DAGchainer...
  31. pmc Twin priming: a proposed mechanism for the creation of inversions in L1 retrotransposition
    E M Ostertag
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genome Res 11:2059-65. 2001
    ..The overhangs then serve as primers for reverse transcription. The data further indicate that a process identical to microhomology-driven single-strand annealing resolves L1 inversion intermediates...
  32. ncbi A draft sequence of the rice genome (Oryza sativa L. ssp. indica)
    Jun Yu
    Beijing Genomics Institute Center of Genomics and Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China
    Science 296:79-92. 2002
    ..4% of predicted rice genes had a homolog in A. thaliana. The large proportion of rice genes with no recognizable homologs is due to a gradient in the GC content of rice coding sequences...
  33. pmc Staphylococcus aureus RNAIII coordinately represses the synthesis of virulence factors and the transcription regulator Rot by an antisense mechanism
    Sandrine Boisset
    Institut National pour la Recherche Médicale INSERM E0230, Universite Lyon 1, Centre National de Référence des Staphylocoques, Faculte Laennec, Lyon, F 69008, France
    Genes Dev 21:1353-66. 2007
    ..These data emphasize the multitude of regulatory steps affected by RNAIII and its 3' domain in establishing a network of S. aureus virulence factors...
  34. pmc The use of coded PCR primers enables high-throughput sequencing of multiple homolog amplification products by 454 parallel sequencing
    Jonas Binladen
    Center for Ancient Genetics, Institute of Biology, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 2:e197. 2007
  35. pmc SmedGD: the Schmidtea mediterranea genome database
    Sofia M C Robb
    Department of Neurobiology and Anatomy, Howard Hughes Medical Institute, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Nucleic Acids Res 36:D599-606. 2008 will prove useful not only to the planarian research community, but also to those engaged in developmental and evolutionary biology, comparative genomics, stem cell research and regeneration...
  36. pmc A universal framework for regulatory element discovery across all genomes and data types
    Olivier Elemento
    Lewis Sigler Institute for Integrative Genomics, Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Mol Cell 28:337-50. 2007
  37. ncbi Evolution of vault RNAs
    Peter F Stadler
    Bioinformatics Group, Department of Computer Science, and Interdisciplinary Center for Bioinformatics, University of Leipzig, Leipzig, Germany
    Mol Biol Evol 26:1975-91. 2009
    ..In teleosts, expression of several paralogous vtRNA genes, most but not all located at the syntenically conserved protocadherin locus, was verified by reverse transcriptase-polymerase chain reaction...
  38. ncbi Fast identification and statistical evaluation of segmental homologies in comparative maps
    Peter P Calabrese
    Department of Mathematics, University of Southern California, Los Angeles, CA 90089, USA
    Bioinformatics 19:i74-80. 2003
    ..However, identification and statistical evaluation of segmental homologies can be a challenge when the segments are highly diverged...
  39. ncbi Highly efficient endogenous human gene correction using designed zinc-finger nucleases
    Fyodor D Urnov
    Sangamo BioSciences, Inc, Pt Richmond Tech Center 501, Canal Blvd, Suite A100 Richmond, California 94804, USA
    Nature 435:646-51. 2005
    ..We observe comparably high frequencies in human T cells, raising the possibility of strategies based on zinc-finger nucleases for the treatment of disease...
  40. ncbi North American and European porcine reproductive and respiratory syndrome viruses differ in non-structural protein coding regions
    R Allende
    Department of Veterinary and Biomedical Sciences, University of Nebraska Lincoln, 68583 0905, USA
    J Gen Virol 80:307-15. 1999
    ..The 3' NCR (150 nucleotides) was 76% identical between isolates. These genomic differences confirm the presence of distinct North American and European PRRSV genotypes...
  41. ncbi Finding a match: how do homologous sequences get together for recombination?
    Adi Barzel
    Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Ramat Aviv 69978, Israel
    Nat Rev Genet 9:27-37. 2008
  42. pmc Two seemingly homologous noncoding RNAs act hierarchically to activate glmS mRNA translation
    Johannes H Urban
    Max Planck Institute for Infection Biology, RNA Biology Group, Berlin, Germany
    PLoS Biol 6:e64. 2008
    ..Our study reveals hierarchical action of two well-conserved sRNAs in a complex regulatory cascade that controls the glmS mRNA. Similar cascades of noncoding RNA regulators may operate in other organisms...
  43. ncbi Isolation of an active human transposable element
    B A Dombroski
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    Science 254:1805-8. 1991
    ..This L1 element contains two open-reading frames and is one of at least four alleles of a locus on chromosome 22 that has been occupied by an L1 element for at least 6 million years...
  44. ncbi A conserved small RNA promotes discoordinate expression of the glmUS operon mRNA to activate GlmS synthesis
    Johannes H Urban
    Max Planck Institute for Infection Biology, RNA Biology, Chariteplatz 1, 10117 Berlin, Germany
    J Mol Biol 373:521-8. 2007
    ..Our data suggest that Gram-negative bacteria evolved a mechanism of glmS riboregulation that is distinct from the glmS riboswitch mechanism of Gram-positive bacteria...
  45. ncbi Evolution of the secondary structure of the rRNA internal transcribed spacer 2 (ITS2) in hard ticks (Ixodidae, Arthropoda)
    O Hlinka
    Department of Microbiology and Parasitology, and Institute for Molecular Biosciences, The University of Queensland, Brisbane 4072, Australia
    Heredity (Edinb) 88:275-9. 2002
  46. pmc Arabidopsis ethylene-responsive element binding factors act as transcriptional activators or repressors of GCC box-mediated gene expression
    S Y Fujimoto
    Plant Molecular Biology Laboratory, National Institute of Bioscience and Human Technology, Tsukuba 305 8566, Japan
    Plant Cell 12:393-404. 2000
    ..Thus, we conclude that AtERFs are factors that respond to extracellular signals to modulate GCC box-mediated gene expression positively or negatively...
  47. ncbi Boca, an endoplasmic reticulum protein required for wingless signaling and trafficking of LDL receptor family members in Drosophila
    Joaquim Culi
    Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, 701 West 168th Street, HHSC 1104, New York, NY 10032, USA
    Cell 112:343-54. 2003
    ..Consequently, boca is an essential component of the Wingless pathway but is more generally required for the activities of multiple LDL receptor family members...
  48. pmc Identification and analysis of 'extended -10' promoters in Escherichia coli
    Jennie E Mitchell
    School of Biosciences, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Nucleic Acids Res 31:4689-95. 2003
    ..We have shown experimentally that the extended -10 5'-TG-3' motif contributes to promoter activity at seven different promoters. The importance of the motif at different promoters is dependent on the sequence of other promoter elements...
  49. ncbi polo encodes a protein kinase homolog required for mitosis in Drosophila
    S Llamazares
    Department of Biochemistry, The University, Dundee, Scotland
    Genes Dev 5:2153-65. 1991
  50. ncbi Minimum length of sequence homology required for in vivo cloning by homologous recombination in yeast
    S B Hua
    GeneNet Group, CLONTECH Laboratories, Inc, Palo Alto, California 94303, USA
    Plasmid 38:91-6. 1997
    ..Some applications, including high-throughput transferring of EST inserts to the yeast expression systems for the Human Genome Project, are discussed...
  51. ncbi MicroRNA binding sites in Arabidopsis class III HD-ZIP mRNAs are required for methylation of the template chromosome
    Ning Bao
    Program in Plant Breeding and Plant Genetics, University of Wisconsin, Madison, WI 53706, USA
    Dev Cell 7:653-62. 2004
    ..These results suggest a model in which the microRNA interacts with nascent, newly processed PHB mRNA to alter chromatin of the corresponding PHB template DNA predominantly in differentiated cells...
  52. pmc Human subtelomeres are hot spots of interchromosomal recombination and segmental duplication
    Elena V Linardopoulou
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North C3 168, Seattle, Washington 98109, USA
    Nature 437:94-100. 2005
    ..More generally, our analyses suggest an evolutionary cycle between segmental polymorphisms and genome rearrangements...
  53. pmc Analyses of LTR-retrotransposon structures reveal recent and rapid genomic DNA loss in rice
    Jianxin Ma
    Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA
    Genome Res 14:860-9. 2004
  54. pmc Sequence variability of a human pseudogene
    R Martinez-Arias
    Unitat de Biologia Evolutiva, Universitat Pompeu Fabra, 08003 Barcelona, Spain
    Genome Res 11:1071-85. 2001
    ..In a deeper timeframe, phylogenetic analysis showed that the duplication event that created psGBA could be dated at approximately 27 million years ago, in agreement with previous estimates...
  55. ncbi Novel SINE families from salmons validate Parahucho (Salmonidae) as a distinct genus and give evidence that SINEs can incorporate LINE-related 3'-tails of other SINEs
    Vitaliy Matveev
    Faculty of Bioscience and Biotechnology, Department of Biological Sciences, Tokyo Institute of Technology, Yokohama, Japan
    Mol Biol Evol 24:1656-66. 2007
    ..Its distribution among salmonids validates Parahucho (Japanese huchen) as a distinct monotypic genus...
  56. ncbi Discovery of regulatory elements in vertebrates through comparative genomics
    Amol Prakash
    Department of Computer Science and Engineering, Box 352350, University of Washington, Seattle, Washington 98195 2350, USA
    Nat Biotechnol 23:1249-56. 2005
    ..The results provide a glimpse into the wealth of information that comparative genomics can yield and suggest the need for further improvement of genome-wide comparative computational techniques...
  57. pmc The mouse homolog of HEN1 is a potential methylase for Piwi-interacting RNAs
    Yohei Kirino
    RNA 13:1397-401. 2007
    ..These findings provide insight into the biogenesis of piRNAs...
  58. ncbi Choosing BLAST options for better detection of orthologs as reciprocal best hits
    Gabriel Moreno-Hagelsieb
    Department of Biology, Wilfrid Laurier University, 75 University Avenue West, Waterloo, ON, Canada, N2L 3C5
    Bioinformatics 24:319-24. 2008
    ..Thus, we decided to test whether such options would help better detect orthologs...
  59. ncbi Differential expression of the embryo/cancer gene ECSA(DPPA2), the cancer/testis gene BORIS and the pluripotency structural gene OCT4, in human preimplantation development
    Marilyn Monk
    Molecular Embryology Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Mol Hum Reprod 14:347-55. 2008
  60. ncbi Divergence of the mitochondrial genome structure in the apicomplexan parasites, Babesia and Theileria
    Kenji Hikosaka
    Laboratory of Malariology, International Research Center of Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
    Mol Biol Evol 27:1107-16. 2010
    ..These results suggest that the Theileria mt genome is highly diverse with lineage-specific evolution in two Theileria species: genome inversion in T. orientalis and gene-embedded long TIR in T. equi...
  61. pmc Identification of novel imprinted genes in a genome-wide screen for maternal methylation
    Rachel J Smith
    Developmental Genetics Program, The Babraham Institute, Cambridge CB2 4AT, UK
    Genome Res 13:558-69. 2003
    ..Interestingly, two of the three novel genes identified in this screen are located within the introns of other genes; their identification indicates that such "microimprinted" domains may be more common than previously thought...
  62. pmc Conservation and divergence of microRNAs in Populus
    Abdelali Barakat
    Department of Biology, Institute of Molecular Evolutionary Genetics, and The Huck Institutes of the Life Sciences, 403 Life Sciences Building, The Pennsylvania State University, University Park, PA 16802, USA
    BMC Genomics 8:481. 2007
    ..In this study, we analyzed expressed small RNAs from leaves and vegetative buds of Populus using high throughput pyrosequencing...
  63. ncbi Conserved and novel miRNAs in the legume Phaseolus vulgaris in response to stress
    Catalina Arenas-Huertero
    Departamento de Biologia Molecular de Plantas, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Av Universidad 2001, Cuernavaca, Morelos, Mexico
    Plant Mol Biol 70:385-401. 2009
    ..vulgaris. We propose that the novel miRNAs present in common bean and other legumes, are involved in regulation of legume-specific processes including adaptation to diverse external cues...
  64. pmc Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc
    R D Palmiter
    Howard Hughes Medical Institute, University of Washington, Seattle 98195
    EMBO J 14:639-49. 1995
    ..We propose that ZnT-1 transports zinc out of cells and that its absence accounts for the increased sensitivity of mutant cells to zinc toxicity...
  65. pmc Gene loss, protein sequence divergence, gene dispensability, expression level, and interactivity are correlated in eukaryotic evolution
    Dmitri M Krylov
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA
    Genome Res 13:2229-35. 2003
    ..Thus, propensity of a gene to be lost during evolution seems to be a direct reflection of its biological importance...
  66. pmc Inferring noncoding RNA families and classes by means of genome-scale structure-based clustering
    Sebastian Will
    Bioinformatics Group, Institute of Computer Science, University of Freiburg, Freiburg, Germany
    PLoS Comput Biol 3:e65. 2007
  67. pmc Hotspots of biased nucleotide substitutions in human genes
    Jonas Berglund
    Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
    PLoS Biol 7:e26. 2009
    ..This process can lead to accelerated evolution in coding sequences and excess amino acid replacement substitutions, thereby generating significant results for tests of positive selection...
  68. ncbi Mitochondrial DNA-like sequences in the nucleus (NUMTs): insights into our African origins and the mechanism of foreign DNA integration
    Dan Mishmar
    The Center of Molecular and Mitochondrial Genetics and Medicine MAMMAG, University of California, Irvine 92597 3940, USA
    Hum Mutat 23:125-33. 2004
    ..Finally, NUMTs appear to preferentially integrate into DNA with different GC content than the surrounding chromosomal band. Our results suggest that chromosomal structure might influence integration of NUMTs...
  69. ncbi Molecular evolution of an ancient mariner transposon, Hsmar1, in the human genome
    H M Robertson
    Department of Entomology, University of Illinois at Urbana Champaign, Urbana 61801, USA
    Gene 205:203-17. 1997
    ..Thus, this transposon had a considerable insertional mutagenic effect on past primate genomes...
  70. ncbi Identification and characterization of human BIC, a gene on chromosome 21 that encodes a noncoding RNA
    W Tam
    Department of Pathology, Joan and Sanford I Weill Medical College of Cornell University, K 508, 525 East 68th Street, New York, NY 10021, USA
    Gene 274:157-67. 2001
    ..Based on the lack of a conserved ORF and the evolutionary conservation of RNA secondary structure, we presume that BIC functions as a noncoding RNA...
  71. ncbi Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC
    Nagi G Ayad
    Department of Cell Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Cell 113:101-13. 2003
    ..Degradation of Tome-1 during G1 allows for wee 1 accumulation during interphase, thereby providing a critical link between the APC and SCF pathways in regulation of cdk1/cyclin B activity and thus mitotic entry and exit...
  72. pmc SGD: Saccharomyces Genome Database
    J M Cherry
    Department of Genetics, Stanford University, Stanford, CA 94305 5120, USA
    Nucleic Acids Res 26:73-9. 1998
    ..SGD can be accessed via the World Wide Web at
  73. ncbi The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme
    J Yuan
    Program of Neurosciences, Harvard Medical School, Boston, Massachusetts 02115
    Cell 75:641-52. 1993
    ..We propose that the CED-3 protein acts as a cysteine protease in the initiation of programmed cell death in C. elegans and that cysteine proteases also function in programmed cell death in mammals...
  74. pmc Characterization of VPI pathogenicity island and CTXphi prophage in environmental strains of Vibrio cholerae
    A K Mukhopadhyay
    Departments of Molecular Microbiology and Genetics, Washington University Medical School, St. Louis, Missouri 63110, USA
    J Bacteriol 183:4737-46. 2001
    ..cholerae strains, suggest that some of these genes contribute to fitness in nature, and emphasize the potential importance of interstrain gene exchange in the evolution of this species...
  75. pmc Identification of TSIX, encoding an RNA antisense to human XIST, reveals differences from its murine counterpart: implications for X inactivation
    B R Migeon
    McKusick Nathans Institute of Genetic Medicine and Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA
    Am J Hum Genet 69:951-60. 2001
    ..These differences could explain the fact that X inactivation is not imprinted in human placenta, and they raise questions about the role of TSIX in random X inactivation...
  76. ncbi Diversity of DNA 1: a satellite-like molecule associated with monopartite begomovirus-DNA beta complexes
    Rob W Briddon
    Department of Disease and Stress Biology, John Innes Centre, Norwich NR4 7UH, UK
    Virology 324:462-74. 2004
    ..The possible origin and function of DNA 1 components are discussed in light of these findings...
  77. ncbi High sequence turnover in the regulatory regions of the developmental gene hunchback in insects
    J M Hancock
    MRC Clinical Sciences Centre, Hammersmith Hospital, London, England
    Mol Biol Evol 16:253-65. 1999
  78. ncbi Genetic variation in prehistoric Sardinia
    David Caramelli
    Dipartimento di Biologia Animale e Genetica, Laboratorio di Antropologia, Universita di Firenze, Firenze, Italy
    Hum Genet 122:327-36. 2007
  79. ncbi Genomic and evolutionary analysis of Feilai, a diverse family of highly reiterated SINEs in the yellow fever mosquito, Aedes aegypti
    Z Tu
    Department of Entomology, University of Arizona, USA
    Mol Biol Evol 16:760-72. 1999
    ..aegypti genome. The evolutionary relationship between Feilai and the Ae. aegypti genome is likely complex...
  80. pmc The microRNAs of Caenorhabditis elegans
    Lee P Lim
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Genes Dev 17:991-1008. 2003
    ..Our census of the worm miRNAs and their expression patterns helps define this class of noncoding RNAs, lays the groundwork for functional studies, and provides the tools for more comprehensive analyses of miRNA genes in other species...
  81. pmc Analysis of small human proteins reveals the translation of upstream open reading frames of mRNAs
    Masaaki Oyama
    Human Genome Center, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    Genome Res 14:2048-52. 2004
    ..This investigation provides the first direct evidence of translation of upstream ORFs in human cells, which could greatly change the current outline of the human proteome...
  82. pmc The Soybean Genome Database (SoyGD): a browser for display of duplicated, polyploid, regions and sequence tagged sites on the integrated physical and genetic maps of Glycine max
    Jeffry L Shultz
    Genomics Core Facility, Southern Illinois University at Carbondale, Carbondale, IL 62901 4415, USA
    Nucleic Acids Res 34:D758-65. 2006
    ..The genome browser portal showed each data type as a separate track. Tetraploid, octoploid, diploid and homologous regions are shown clearly in relation to an integrated genetic and physical map...
  83. ncbi ITS secondary structure derived from comparative analysis: implications for sequence alignment and phylogeny of the Asteraceae
    Leslie R Goertzen
    Section of Integrative Biology and Institute of Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA
    Mol Phylogenet Evol 29:216-34. 2003
    ..Combined analyses of ndhF and ITS sequences provide additional resolution and support for relationships in the family...
  84. ncbi Cyclin E expression during development in Caenorhabditis elegans
    Thomas M Brodigan
    Laboratory of Molecular Biology, NIDDK, NIH, Bethesda, MD 20892, USA
    Dev Biol 254:102-15. 2003
    ..Our analysis of a new cye-1 deletion allele confirms and extends previous studies of two point mutations in the gene...
  85. pmc A new family of Ty1-copia-like retrotransposons originated in the tomato genome by a recent horizontal transfer event
    Xudong Cheng
    The State Key Laboratory of Plant Cell and Chromosome Engineering, National Center for Plant Gene Research, Beijing, China
    Genetics 181:1183-93. 2009
    ..Considering its transcriptional activity and the recent insertion of the element into at least two genes, Rider is a recently active retrotransposon in the tomato genome...
  86. ncbi Two pathways of homologous recombination in Trypanosoma brucei
    Colin Conway
    The Wellcome Centre for Molecular Parasitology, The Anderson College, University of Glasgow, UK
    Mol Microbiol 45:1687-700. 2002
    ..We show that the RAD51-independent pathway is capable of recombining DNA substrates with very short lengths of sequence homology and in some cases aberrant recombination reactions can be detected using such microhomologies...
  87. ncbi Hox genes and the evolution of vertebrate axial morphology
    A C Burke
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Development 121:333-46. 1995
    ..The recognition of mechanistic homology supports the historical homology of basic patterning mechanisms between all organisms that share these genes...
  88. ncbi Development of microsatellite markers and analysis of intraspecific genetic variability in chickpea (Cicer arietinum L.)
    Niroj Kumar Sethy
    National Centre for Plant Genome Research, Jawaharlal Nehru University Campus, Post Box No 10531, New Delhi, 110067, India
    Theor Appl Genet 112:1416-28. 2006
    ..The microsatellite markers developed in this study will be useful for genetic diversity analysis, linkage map construction as well as for depicting intraspecific microsatellite evolution...
  89. pmc Escherichia coli has two homologous glutamate decarboxylase genes that map to distinct loci
    D K Smith
    Department of Medical Microbiology, University of Alberta, Edmonton, Canada
    J Bacteriol 174:5820-6. 1992
    ..Information about the DNA sequences and map positions of gadA and gadB should facilitate a genetic approach to elucidate the role of GAD in E. coli metabolism...
  90. ncbi The protein Id: a negative regulator of helix-loop-helix DNA binding proteins
    R Benezra
    Department of Genetics, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
    Cell 61:49-59. 1990
    ..Based on these findings, we propose that HLH proteins lacking a basic region may negatively regulate other HLH proteins through the formation of nonfunctional heterodimeric complexes...
  91. pmc Meningococcal genetic variation mechanisms viewed through comparative analysis of serogroup C strain FAM18
    Stephen D Bentley
    Wellcome Trust Sanger Institute, Hinxton, United Kingdom
    PLoS Genet 3:e23. 2007
  92. ncbi Comparative genomics identifies a flagellar and basal body proteome that includes the BBS5 human disease gene
    Jin Billy Li
    Department of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA
    Cell 117:541-52. 2004
    ..We show that this novel protein localizes to basal bodies in mouse and C. elegans, is under the regulatory control of daf-19, and is necessary for the generation of both cilia and flagella...
  93. ncbi Evolutionary sequence comparison of the Mitf gene reveals novel conserved domains
    Jón Hallsteinn Hallsson
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Iceland, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland
    Pigment Cell Res 20:185-200. 2007
    ..Our analysis sheds new light on the conservation of the Mitf gene and protein and opens the door for further functional analysis...
  94. ncbi A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells
    U Gunthert
    Institut fur Genetik, Universitat Karlsruhe, Federal Republic of Germany
    Cell 65:13-24. 1991
    ..Overexpression of pMeta-1 in the nonmetastasizing BSp73AS cells suffices to establish full metastatic behavior...
  95. pmc Genetic diversity and mosaicism at the por locus of Neisseria gonorrhoeae
    T C Fudyk
    Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
    J Bacteriol 181:5591-9. 1999
    ..Despite extensive sequence variability, por expressed by gonococcal isolates of different geographic origin exhibited conserved patterns of nucleotide change, suggesting that diversity among por alleles may also be finite...
  96. pmc Identification of mammalian microRNA host genes and transcription units
    Antony Rodriguez
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, United Kingdom
    Genome Res 14:1902-10. 2004
  97. ncbi Structures, regulatory regions, and inductive expression patterns of antimicrobial peptide genes in the silkworm Bombyx mori
    Tingcai Cheng
    The Key Sericultural Laboratory of Agricultural Ministry, Southwest University, Chongqing 400716, China
    Genomics 87:356-65. 2006
    ..Such results suggest that these regulatory elements and their positions in the upstream regions play an important role in regulating the transcription of these defense genes...
  98. pmc Cloning and characterization of microRNAs from rice
    Ramanjulu Sunkar
    Institute for Integrative Genome Biology and Department of Botany and Plant Sciences, University of California, Riverside, California 92521
    Plant Cell 17:1397-411. 2005
    ..Four target genes have been experimentally verified by detection of miRNA-mediated mRNA cleavage. Our identification of new miRNAs in rice suggests that these miRNAs may have evolved independently in rice or been lost in other species...
  99. ncbi The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes
    Helen Skaletsky
    Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 423:825-37. 2003
    ..9% identity, which is maintained by frequent gene conversion (non-reciprocal transfer). The most prominent features here are eight massive palindromes, at least six of which contain testis genes...
  100. pmc CARNAC: folding families of related RNAs
    Hélène Touzet
    Laboratoire d Informatique Fondamentale de Lille, UMR CNRS 8022, Universite des Sciences et Technologies de Lille, France
    Nucleic Acids Res 32:W142-5. 2004
    ..The functionality is demonstrated using three example datasets: sequences of RNase P RNAs, ciliate telomerases and enterovirus messenger RNAs. CARNAC has a web server that can be accessed at the URL
  101. ncbi Genomic characterization of Rim2/Hipa elements reveals a CACTA-like transposon superfamily with unique features in the rice genome
    G D Wang
    SHARF and National Laboratory of Plant Molecular Genetics, Shanghai Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 300 Fenglin Road, 200032 Shanghai, China
    Mol Genet Genomics 270:234-42. 2003
    ..Our results demonstrate that the Rim2 elements from rice belong to a distinct superfamily of CACTA-like elements with evolutionary diversity...

Research Grants62

    John Oakes; Fiscal Year: 1980
  2. Microecology-murine gut-initiation & progression of IBD
    James Fox; Fiscal Year: 2005
    ..prior and subsequent to oral vaccination with Helicobacter spp. antigens and mucosal adjuvants, elucidate how these vaccine strategies influence microflora dynamics and impact gut cytokine responses. ..
  3. HUS Pathogenesis & clinical Outcome in an in vivo model
    James Fox; Fiscal Year: 2008
    ..We will use this model to study the pathogenesis of HUS and importantly to develop therapeutic regimens to prevent and treat EHEC disease. [unreadable] [unreadable] [unreadable] [unreadable]..
    James Fox; Fiscal Year: 2009
    ..pylori pathogenesis and specifically evaluate the role of regulatory T cells in limiting H. pylori-induced gastric pathology. ..
  5. Helicobacter induced hepatitis and tumorigenesis
    James Fox; Fiscal Year: 2009
    ..A more complete understanding of the etiopathogenesis of hepatobiliary disease and hepatocellular carcinoma is likely to result in new strategies for treatment and prevention of these important human diseases. ..
    James Fox; Fiscal Year: 2006
  7. Characterization of a large protein interaction network
    Andreas Wagner; Fiscal Year: 2005
    ..The proposed work will put this speculation to an end for a key genetic network, some of whose conserved components are also involved in the etiology of human disease. ..
    Daekyu Sun; Fiscal Year: 2002
    ..3) Test whether DNA ligase I inhibition produces antitumor activity using antisense strategy in preclinical in vitro and in vivo evaluation systems. 4) Develop a sensitive and reproducible assay for DNA ligase I. ..
    Austin L Hughes; Fiscal Year: 2010
    ..In addition, by increasing our understanding of the population diversity and evolutionary history of human immune system genes, this research will enhance our knowledge of human immune function in health and disease. ..
  10. Expression of Human Therapeutic Proteins in Transgenic Tobacco Chloroplasts
    Henry Daniell; Fiscal Year: 2010
    ..Successful completion of these studies would make transgenic chloroplasts ideal bioreactors for the production of safe and less expensive therapeutic proteins and open the door for in depth studies of membrane proteins. ..
  11. Effect of parkin on DNA damage induced rearrangements
    ROBERT SCHIESTL; Fiscal Year: 2006
    ..If our hypothesis turns out to be true, one could use these mice as model systems to further study the mechanistic basis of the interaction of lack of parkin with DNA repair and cancer. ..
  12. Mitotic Checkpoint Regulators: Roles in Development and Cancer
    William F Marzluff; Fiscal Year: 2010
  13. Latent virus and HIV-1 specific immunity in LTNPs
    Joel Blankson; Fiscal Year: 2006
    ..Siliciano, and the supportive environment of the Johns Hopkins University will provide Dr. Blankson with the skills he needs to develop into an independent clinician and basic scientist researcher in HIV-1 pathogenesis. ..
  14. A Rapid Method for HLA-typing by Haplotyping
    Johannes Dapprich; Fiscal Year: 2006
    ..It is a further goal of Phase II to demonstrate the direct compatibility of HSE with existing SNP-mapping information and to expand the automation of HSE to a 96-well platform. ..
  15. Identification of Tetrahymena DNA Rearrangement Genes
    DOUGLAS LEE CHALKER; Fiscal Year: 2010
    ..abstract_text> ..
  16. Molecular Targets in Bronchopulmonary Dysplasia
    Richard Pierce; Fiscal Year: 2006
    ..These studies will be highly interactive within the Consortium and provide gene expression data for the scientific community at large. ..
  17. Mycobacteriophage-mediated Recombineering in Mycobacterium tuberculosis
    Graham Hatfull; Fiscal Year: 2007
    ..These putative recombination proteins will be functionally and biochemically characterized and used to develop recombineering systems in both fast- and slow-growing mycobacteria. ..
    Craig Stevens; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
    Heather Yeowell; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  20. Phage mimicry of mycobacterial signaling
    Graham F Hatfull; Fiscal Year: 2010
    ..We propose to elucidate the specific role of GroEL1 in biofilm formation and mycolic acid synthesis, and to determine its role in the pathogenesis of Mycobacterium tuberculosis. ..
  21. Hsal 2, A Novel Homeobox Gene in Hematopoiesis
    Li Chai; Fiscal Year: 2007
    ..In addition, a further objective of this proposal is to serve as a vehicle for the development of the candidate into an independent and productive investigator in the area of hematopoiesis and leukemogenesis. ..
  22. Fragment assembly and metabolic/species diversity analysis for Human microbiome p
    Yuzhen Ye; Fiscal Year: 2010
  23. Viral-Driven Mediators of Chronic Lung Allograft Dysfunction
    Richard Pierce; Fiscal Year: 2009
    ..This research will study how these viruses cause chronic lung rejection so that treatments for this condition can be developed. (End of Abstract) ..
  24. Comparative genomics with the VISTA/LAGAN computational system
    Inna Dubchak; Fiscal Year: 2009
    ..The target users of these resources will continue to be biomedical researchers, and thus focus will be placed on generating tools and databases that will be easy to use with readily interpretable results. ..
  25. The Mechanisms and Regulatory Networks of Alternative Splicing in Drosophila
    BRENTON GRAVELEY; Fiscal Year: 2009
  26. Comparative Genomics of Sex Determination in Amniotes
    Turk Rhen; Fiscal Year: 2006
    ..This approach promises to speed the rate of discovery of sex-determining genes in humans, which to date has been slow and haphazard. ..
    William Marzluff; Fiscal Year: 2001
    ..Together, these five objectives delineate a research strategy that will allow resolution of the seemingly contradictory evidence relating aluminum to neurological degeneration. ..
    Graham Hatfull; Fiscal Year: 2004
    ..We will also use proteomic approaches to understand the influence of phage gene expression on that of its host. ..
  29. Evolutionary genomics of new Drosophila genes
    DAVEN PRESGRAVES; Fiscal Year: 2004
    ..The methods developed will be applicable in comparative analysis of other genomes, including those of humans and their primate relatives. ..
  30. Sequence alignment fidelity in genomics and bioinformatics
    Michael S Rosenberg; Fiscal Year: 2010
  31. Zeiss LSM 510 META Confocal Microscope
    JAMES CARRINGTON; Fiscal Year: 2003
    Fred Wright; Fiscal Year: 2002
    ..The robustness and wide applicability of the methods proposed will be examined using a combination of simulation and analysis of existing linkage datasets. ..
    Judith Potashkin; Fiscal Year: 2004
    ..Because dFosB is also induced by chronic administration of other drugs of abuse, such as amphetamine, nicotine and opiates, the results obtained in this study may also lead to a better understanding of drug addiction. ..
  34. Mechanism of in-vitro aging
    LYSLE LEWIS; Fiscal Year: 2007
    ..The proposed research will enhance our understanding of events that occur as a consequence of shortened chromosomes and factors that affect the rate of shortening. [unreadable] [unreadable] [unreadable]..
  35. Genetics of Anopheles funestus populations
    Nora Besansky; Fiscal Year: 2005
    ..funestus become possible ..
  36. Antioxidant Therapy for Ataxia Telangiectasia
    ROBERT SCHIESTL; Fiscal Year: 2009
  37. Targeting Tumor Angiogenesis with G-Quadruplex Binders
    Daekyu Sun; Fiscal Year: 2010
    ..abstract_text> ..
    Graham Hatfull; Fiscal Year: 2003
    ..tuberculoses to determine whether they have functional recombination systems; whether they act as Genetic Transfer Agents; and whether they play a role in virulence of M. tuberculosis. ..
    JAMES CARRINGTON; Fiscal Year: 2003
    ..Identification of these host mutants will provide the starting point for isolation of genes involved in NIa-interacting reactions and pathways. ..
  40. Deciphering the regulatory code of a cell
    Gary D Stormo; Fiscal Year: 2010
    ..This approach will be initially developed and tested using a few well characterized binding sites;we expect it will provide a general tool for more comprehensive studies of the logic of gene regulation. ..
    CHRISTOPHER HELLEN; Fiscal Year: 2001
    ..abstract_text> ..
    Nora Besansky; Fiscal Year: 2003
    ..gambiae and An. arabiensis sister taxa? (2) How much gene flow is occurring between them, and which genomic regions are susceptible? (3) How much gene flow is occurring between chromosomal forms of An. gambiae? ..
  43. Effect of Diesel Exhaust Particles on DNA Deletions
    ROBERT SCHIESTL; Fiscal Year: 2006
    ..abstract_text> ..
  44. Gene Duplication and Genome Evolution
    Austin Hughes; Fiscal Year: 2004
    ..5) Examining the role of transposable elements in duplication of genomic segments by testing for nonrandom association between these elements and putatively duplicated blocks in the yeast genome. ..
    Brian Fox; Fiscal Year: 2007
    ..The potential of using related molecules to inactivate other position-specific desaturases will be determined. ..
  46. Automated preparation of megabase genomic DNA
    Johannes Dapprich; Fiscal Year: 2006
    ..This understanding should lead to a better understanding of the etiology of genetic disorders, which should ultimately result in better treatments and preventive care. [unreadable] [unreadable] [unreadable]..
  47. Screen for molecules inhibiting histone pre-mRNA process
    William Marzluff; Fiscal Year: 2006
    ..We are adapting the screen to an automated microscope which can rapidly read the 384 well plates. ..
    Herbert Lachman; Fiscal Year: 2005
    ..By the end of the project, which will coincide with the completion of the human genome project, they will be able to analyze all of the specific candidate genes that map to linked markers. ..
  49. Matrix Metalloproteinases, Exercise, and Muscle Damage
    David Allen; Fiscal Year: 2008
    ..Finally, subjects will be genotyped for known functional MMP promoter polymorphisms, which will be correlated with MMP levels and muscle damage and soreness following eccentric exercise. ..
  50. Regulatory elements controlling elastin transcription
    Richard Pierce; Fiscal Year: 2005
    ..These approaches will reveal key mechanisms controlling elastin synthesis and identify targets for strategies to modulate elastin synthesis in the lungs of premature infants and in pulmonary emphysema. ..
    MONICA JEAN JUSTICE; Fiscal Year: 2010 Our previous work has made a difference in the way we can approach mouse genetics, and our proposed work will influence the way we understand what genes do and how they work in mammals. ..
  52. High through-put detection of fungal pathogens
    JACK FELL; Fiscal Year: 2004
    ..Resulting data will be disseminated via GenBank, publications in leading scientific journals and as an inexpensive commercial detection system. ..
  53. Phosphorylation dependent recognition of a histone mRNA hairpin by SLBP
    William Marzluff; Fiscal Year: 2009
    ..abstract_text> ..
  54. Characterization of HIV excape mutants and T cell responses in elite suppressors
    Joel Blankson; Fiscal Year: 2007
    ..This may allow some patients to control the virus without antiretroviral therapy for prolonged periods of time. ..
  55. Exploring microbial diversity for novel natural products
    JULIE OLSON; Fiscal Year: 2004
  56. Receptor Phosphatases and Process Outgrowth
    Eduardo Macagno; Fiscal Year: 2005
  57. Microsimulation of anthracis-immune system interaction
    THOMAS KEPLER; Fiscal Year: 2005
  58. Middle Ear Epithelial Response to Cytokine Stimulation
    Joseph Kerschner; Fiscal Year: 2005
  59. Nitric Oxide Metabolism in Statin-treated Pediatric SLE
    MARC LEVESQUE; Fiscal Year: 2006
    ..In addition, these DNA samples will constitute an important resource for future genetic analyses of pediatric SLE. [unreadable] [unreadable] [unreadable]..
    William Scott; Fiscal Year: 2008
    ..abstract_text> ..